がん特別調査に関する総括研究

• 研究課題/領域番号: 06042021
• 研究種目: 国際学術研究
• 配分区分: 補助金
• 応募区分: がん調査
• 研究機関: 愛知県がんセンター
• 研究代表者: 富永 祐民 愛知県がんセンター研究所, 所長 (30124530)
• 研究分担者: 藤山 千早 鹿児島大学, 医学部・公衆衛生学教室, 助手 (30274814) ; 池田 憲昭 愛知学院大学, 歯学部・口腔外科学第2講座, 講師 (30150791) ; 佐々木 隆一郎 愛知医科大学, 公衆衛生学教室, 教授 (80131241) ; 市橋 正光 神戸大学, 医学部・皮膚科学講座, 教授 (00030867) ; 清水 弘之 岐阜大学, 医学部・公衆衛生学教室, 教授 (90073139) ; 田島 和雄 愛知県がんセンター研究所, 疫学部, 部長 (30150212) ; 吉村 健清 産業医科大学, 産業生態科学研究所, 教授 (20037435) ; 大野 良之 名古屋大学, 医学部・予防医学教室, 教授 (10160590) ; 藤木 博太 埼玉県立がんセンター研究所, 所長 (60124426) ; 廣橋 説雄 国立がんセンター研究所, 副所長 (70129625) ; 吉田 光昭 東京大学, 医科学研究所, 所長 (80012607) ; 山本 雅 東京大学医科学研究所, 制癌研究部, 教授 (40134621) ; 黒木 登志夫 昭和大学, 腫瘍分子生物学研究所, 所長 (90006073) ; 北川 知行 癌研究会癌研究所, 所長 (50085619)
• 研究期間 (年度): 1994 – 1996
• 研究課題ステータス: 完了 (1996年度)
• 配分額: 13,500千円 (直接経費: 13,500千円); 1996年度: 4,300千円 (直接経費: 4,300千円); 1995年度: 4,300千円 (直接経費: 4,300千円); 1994年度: 4,900千円 (直接経費: 4,900千円)
• キーワード: がん / 胃がん / 食道がん / 肝がん / 皮膚がん / 中国 / 東南アジア / 中南米 / 大腸がん / EBウイルス / フランス / ギリシャ / 口腔がん / マレーシア / インドネシア / 肺がん / ホンコン

研究概要

本研究班は文部省国際学術研究がん特別調査関係の研究を効果的に、且つ円滑に実施するために、以下の研究及び活動を行った。
1)計画研究課題の企画と選定
「計画研究」は特に重要で、成果が期待できる骨格的な研究課題とし、総括班を除いて、平成6年度に11課題、平成7年度に新規4課題のを含めて10課題、平成8年度に新規3課題を含めて10課題を企画、選定した。平成6-8年度を通じて延べ35件、実15件の計画研究が行われた。なお、新規の計画研究を企画、実施する前に、必要に応じて予備調査を実施していたので、計画調査はいずれも順調に進み、優れた研究成果をおさめた。ちなみに、3年間の全研究課題、延べ76件に占める計画研究は延べ35件であった。
2)予備調査の企画、選定、実施
本研究班においては計画研究の企画、選定に先立ち、相手国の受け入れ体制、研究の実施可能性、期待される成果、基礎的情報の収集のために予備調査を実施した。「予備調査」は通常2年度にわたって行っている。第1年目には相手国の受け入れ体制、研究の実施可能性及び基礎的情報を収集し、研究の実施が可能であり、且つ研究成果が期待できることがわかれば、2年目に本調査の研究計画の申請をすると共に、再度予備調査を行い、研究方法などについてさらに具体的な打ち合わせ、準備を行っている。
平成6-8年度には下記の5件の予備調査を行った。
(1)胃・食道がんの比較疫学的研究(中国)
(2)栄養と口腔がんに関する疫学的研究(マレーシア)
(3)皮膚がんの発症要因に関する研究(インドネシア)
(4)アジア地域におけるEBウイルス感染と胃がんの関係についての疫学的研究(ホンコン、タイ、マレーシア)
(5)地中海沿岸諸国の食生活(特に、脂肪摂取)とがんの関係に関する疫学的研究(ギリシャ、フランス)
平成6年度に1年目の予備調査を行い、平成7年度に2年目の予備調査を終了した2件の予備調査((1)と(2))は、いずれも平成8年度から本調査に入った。
平成8年度に予備調査を終了した他の1件の予備調査((3))も平成9年度から本調査に入る予定である。
3)班長会議の開催
毎年1回、年度末頃(3月中旬)に班長会議を開催し、研究の進歩状況及び成果の発表、研究実施上の問題点の討議、情報交換などを行った。平成7年度には研究者が外国で事故にあって負傷を負ったり、病気のために研究の遂行に支障が生じたなどの健康上の問題があったが、その他の研究はいずれも予定通り円滑に行われ、研究成果をおさめることができた。
4)公開研究報告会の開催
毎年1回、年度末頃(3月中旬)に班長会議の開催に併せて公開研究報告会を開催し、がん特別調査で得られた重要な成果を順次発表した。平成6年度の第10回研究報告会は平成5年度までの10年間の研究を総括するために、国際的な公開研究報告会を開催し、外国の共同研究者8名を含めて22名の研究者が主要研究成果を報告した。平成7年度の第11回研究報告会では6人、平成8年度の第12回研究報告会では7人の研究者が研究成果を報告した。
5)がん特別調査ニュースレターの発刊
がん特別調査関係の研究班及びその他の関連研究グループ(文部省がん重点領域研究、国際学術研究総括班など)との情報交換を密にするために、平成2年度からがん特別調査ニュースレターを発刊しいる。平成6年度から平成8年度までに毎年3号、延べ9号(No.12-No.20)を発刊し、関係者に配布した。
6)がん特別調査10年間の研究成果のまとめ
平成6年度には昭和59年度から平成5年度までの10年間のがん特別調査の研究成果を冊子にまとめた。

研究成果

• [文献書誌] 富永祐民: "日本の癌,世界の癌-最近の動向" 癌と化学療法. 22. 1-8 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kawabuchi,B.: "Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse strain conaining an albumin promoter-fused simian virus 40 large T angigen gene." Jpn.J.Cancer Res.85. 601-609 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yamamoto,N.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Miyasaka,K.: "Frequent loss of haterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas in culture" Molecular Carcinogenesis. 13. 37-43 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ikuta,T.: "Cholesterol sulfate,a novel activator for the η isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kuroki,T.: "Evaluation of carcinogenic risks to humans : A list of the IARC." Jpn.J.Cancer Res.85. 1320-1321 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Umemori,H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Fujimoto,J.: "brt,a mouse gene encoding a novel receptor-type protein-tyrosine kinase,is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suzuki,T.: "Tax protein of HTLV-1 interacts with the Re1 homology domain of NF-κB p65 and c-Re1 proteins bound to the NF-κB binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hirai,H.: "Tax pretein of human T-cell leukemia virus type 1 binds to the ankyrin motifs of inhibitory factor κB and induces nuclear translocation of transcription factor NF-κB proteins for transcriptional activation." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Furukawa,Y.: "HTLV-1 Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leulemia cells." Blood. 85. 1865-1870 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kihana,T.: "Pregnostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tsuda,H.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extend of spread." Cancer Res.54. 513-517 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tsuda,H.: "Association among p53 gene mutation,nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Fujiki,H.: "Tumor necrosis factor-α,a new tumor promoter,enegendered bybiochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Fujiki,H.: "A new tumor promotion pathway and its inhibitors." Cencer Detection and Prevention. 18. 1-7 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ohta,T.: "Nodularin,a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tamakoshi,A.: "Serum cholesterol and cancer mortality in Japanese civil service workers : Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Wakai,K.: "Risk factors for breast cancer among Japanese women in Tokyo : A case-control study." J.Epidemiol.4. 65-71 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] 吉村健清: "もう1つの大久野島-旧毒ガス弾製造工場従事者の慢性気管支炎有病率-" 医学のあゆみ. 170. 950-951 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Washio,M.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka,Japan : A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Zaninovic,V.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia" AIDS Res Human Reroviruses. 10. 97-101 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] 柳生聖子: "女性における血清βカロチン値の変動に関する縦断的研究" 医学と生物学. 129. 29-33 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] 伊藤宜則: "南北海道住民における血清カロチノイド、レチノール及びα-トコフェロール値と血清過酸化脂質値との関連性" ビタミン. 68. 351-363 (1994)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tominaga,S.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Miyasaka,K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suzuki,T.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Prince Masahito: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Chida,K.: "Cholesterol sulfate,a second messenger for the η isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Koike,M.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suzuki,T.: "Tax protein of HTLV-1 destabilizes the complexs of NF-κB and 1κB-α and induces nuclear translocation NF-κB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Furukawa,Y.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood.85. 1865-1870 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kanai,Y.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochem.Biophys.Res.Commun.208. 1067-1072 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Shimoyama,Y.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yoshimura,K.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Rroc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Sueoka,E.: "Activation of protein kinase C by mycobacterian cord necrosis factor-α release in mouse lung tissues." Jpn.J.Cancer Res.86. 749-755 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suganuma,M.: "Tautomycin : an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ohno,Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia.4. 131-134 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Budiningsih,S.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ohno Y.: "Tea consumption and lung cancer risk : A case-control study in Okinawa,Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Saku,M.: "Mortality in psychiatric patients,with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ogura,C.: "Prevalence of senile dementia in Okinawa,Japan." International Journal of Epidemiology. 24. 373-380 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Takezaki,T.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Inoue,M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Inoue,M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex,age,and season." J.Clin.Epidemiol.50. 69-77 (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Koo,L.C.: "Dietary and lifestyle correlates of passive smoking in Hong Kong,Japan,Sweden,and USA." Social Science and Medicine. in press (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tsunashima,K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Koyama,Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human α-fetoprotein isoforms produced in transgenic mice." Biocehmical and Biiophysical Research Communications. 223. 757-761 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ishida,T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kuroki,T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Koike,M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes,but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Jia,L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.in press (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Murakami,A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest.Dermatol.106. 790-794 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Fujimoto,J.: "Characterization of the transforming activity of p80,a hyperphosphorylated protein in a ki-1 lymphoma cell line with t (2;5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Iwahara,T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tezuka,T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase,p53/56 lyn,in the B cell antigen recoptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yoshida,M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7. 349-360 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suzuki,T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<INK4A> and counteracts its inhibitory activity towards CDK4." The EMBO J.15. 1607-1614 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Baffa,R.: "Loss of heterozygosity for chromosome II in adenocarcinoma of the stomach." Cancer Research. 56. 268-272 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ochiai,A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69. 28-33 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Taylor,C.: "Inhibition of Protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Quinn,R.J.: "Inhibition of Protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Priharutono,J.: "Breast cancer case control study : conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4. 143-147 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suzuki,S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal of Indonesia. 4. 169-176 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Wakai,K.: "A case-control study of breast cancer among Japanese women in Tokyo" Medical Journal of Indonesia. 4. 177-182 (1995)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] 徳井 教孝: "萎縮性胃炎とHelicobacter pylori感染の血清疫学研究" 産業医科大学雑誌. 18. 133-140 (1996)
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• [文献書誌] 西阪 眞一: "地域住民における健康度自己評価とその後の死亡 -7年間の追跡研究-" 作業医科大学雑誌. 18. (1996)
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• [文献書誌] Utoguchi,K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). 119-131 (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tajima,K.: "Research activities of epidemiology in Japan : Infectious disease,epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tajima,K.: "Ethnoepidemiology,a new paradigm,for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tajima,K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Shimizu,H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hu,Y.H.: "Association of body mass index,physical activity and reproductive histories with breast cancer : A case control study in Gifu,Japan." Breast Cancer Research and Treatment. (in press). (1997)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Nagata,C.: "Choice of response scale for health measurement : Comparison of 4,5,and 7-point scales and visual analog scale." Journal of Epidemiology. 6. 192-1297 (1996)
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• [文献書誌] Kuroishi,T.: "Gann Monograph on Cancer Research No.41 : Cancer Mortality and Morbidity Statistics" Japan Scientific Societies Press,Tokyo,(1994)
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• [文献書誌] Tominaga,S.: "Cancer Surveys Vol.19/20 : Trends in Cancer Incidence and Mortality" Cold Spring Harbor Laboratory Press, 583 (1994)
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• [文献書誌] Tominaga,S.: "Can they be controlled? In Proceedings of the International Cancer Congress. Plenary and Special Lectures" Monduzzi Editore,Bologna, (1994)
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• [文献書誌] Ohno,Y.: "Fundamental Approaches to the Diagnosis and Treatment for Prostate Cancer and BPH" Adenine Press, (1994)
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• [文献書誌] Tajima,K.: "Adult T-cell leukemia" Oxford Univ.Press, 230 (1994)
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• [文献書誌] Fujiki,H.: "Toxic Microcystits" CRC Press, 203-212 (1996)
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• [文献書誌] Kawabuch, B.: "Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse n strain conaining an albumin promoter-fused simian virus 40 large T angige gene." Jpn.J.Cancer Res.85. 601-609 (1994)
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• [文献書誌] Yamamoto, N.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4- dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)
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• [文献書誌] Miyasaka, K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine- induced C3H/HSM mouse hepatocellular carcinomas in culture" Molecular Carcinogenesis. 13. 37-43 (1995)
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• [文献書誌] Ikuta, T.: "Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)
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• [文献書誌] Kuroki, T.: "Evaluation of carcinogenic risks to humans : A list of the IARC." Jpn.j.Cancer Res.85. 1320-1321 (1994)
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• [文献書誌] Umemori, H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)
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• [文献書誌] Umemori, H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)
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• [文献書誌] Fujimoto, J.: "brt, a mouse gene encoding a novel recepter-type protein-tyrosine kinase, is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)
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• [文献書誌] Suzuki, T.: "Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappaB P65 and c-Rel Proteins bound to the NF-kappaB binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hirai, H.: "Tax pretein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappaB and induces nuclear translocation of transcription factor NF-kappaB proteins for transcriptional activation." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)
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• [文献書誌] Furukawa, Y.: "HTLV-1 Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leulemia cells." Blood. 85. 1865-1870 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kihana, T.: "Pregnostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)
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• [文献書誌] Tsuda, H.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread." Cancer Res.54. 513-517 (1994)
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• [文献書誌] Tsuda, H.: "Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)
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• [文献書誌] Fujiki, H.: "Tumor necrosis factor-alpha, a new tumor promoter, enegendered by biochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)
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• [文献書誌] Fujiki, H.: "A new tumor promotion pathway and its inhibitors." Cancer Detection and prevention. 18. 1-7 (1994)
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• [文献書誌] Ohta, T.: "Nobdlarin, a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)
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• [文献書誌] Tamakoshi, A.: "Serum cholesterol and cancer mortality in Japanese civil service workers : Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)
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• [文献書誌] Wakai, K.: "Risk factors for breast cancer among Japanese women in Tokyo : A case-control study." J.Epidemiol.4. 65-71 (1994)
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• [文献書誌] Washio, M.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka, Japan : A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)
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• [文献書誌] Zaninovic, V.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia." AIDS Res Human Reroviruses. 10. 97-101 (1994)
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• [文献書誌] Tominaga, S.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Miyasaka, K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Suzuki, T.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Prince Masahito: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)
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• [文献書誌] Chida, K.: "Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Koike M.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Suzuki, T.: "Tax protein of HTLV-1 destabilizes the complex of NF-kappaB and I kappaB-alpha and induces nuclear translocation NF-kappaB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Furukawa, Y.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood. 85. 1865-1870 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kanai, Y.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochem.Biophys.Res.Commun.208. 1067-1072 (1995)
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• [文献書誌] Shimoyama, Y.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)
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• [文献書誌] Yoshimura, K.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Proc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)
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• [文献書誌] Sueoka, E.: "Activation of protein kinase C by mycobacterial cord necrosis factor-alpha release in mouse lung tissues." Jpn.J.Cancer Res.86. 749-755 (1995)
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• [文献書誌] Suganuma, M.: "Tautomycin : an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)
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• [文献書誌] Ohno, Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia. 4. 131-134 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Budiningsih, S.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)
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• [文献書誌] Ohno Y.: "Tea consumption and lung cancer risk : A case-control study in Okinawa, Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Saku, M: "Mortality in psychiatric patients, with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ogura, C.: "Prevalence of senile dementia in Okinawa, Japan." International Journal of Epidemiology. 24. 373-380 (1995)
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• [文献書誌] Takezaki, T.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Inoue, M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)
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• [文献書誌] Inoue, M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex, age, and season." J.Clin.Epidemiol.50. 69-77 (1997)
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• [文献書誌] Koo, L,C.: "Dietary and lifestyle correlates of passive smoking in Hong kong, Japan, Sweden, and USA." Social Science and Medicine. (in press). (1997)
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• [文献書誌] Tsunashima, K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Koyama, Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human alpha-fetoprotein isoforms produced in transgenic mice." Biocemical and Biophysical Research Communications. 223. 757-761 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ishida, T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kuroki, T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Koike, M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes, but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Jia, L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.(in press). (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Murakami, A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest, Dermatol.106. 790-794 (1996)
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• [文献書誌] Fijimoto, J.: "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with (2 ; 5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)
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• [文献書誌] Iwahara, T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tezuka, T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase, p53/561yn, in the B cell antigen receptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)
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• [文献書誌] Yoshida, M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7. 349-360 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Suzuki, T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<1NK4A> and counteracts its inhibitory activity towards CDK4." The EMBO J.15. 1607-1614 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Baffa, R.: "Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach." Cancer Research. 56. 268-272 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ochiai, A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69. 28-33 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Teylor, C.: "Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Quinn, R.J.: "Inhibition of protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Priharutono, J.: "Breast cancer case control study ; conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4. 143-147 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Suzuki, S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal Indonesia. 4. 169-176 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Wakai, K.: "A case-control study of breast cancer among Japanese women in Tokyo." Medical Journal of Indonesia. 4. 177-182 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Utoguchi, K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tajima, K: "Research activities of epidemiology in Japan : Infectious disease, epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tajima, K.: "Ethnoepidemiology, a new paradigm, for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tajima, K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Shimizu, H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hu, Y.H.: "Association of body mass index, physical activity and reproductive histories with breast cancer : A case control study in Gifu, Japan." Breast Cancer Research and Treatment. (in press). (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nagata, C.: "Choice of response scale for health measurement : Comparison of 4,5. and 7-point scales and visual analog scale." Journal of Epidemiology. 6. 192-197 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
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