神経回路の機能発達

• 研究課題/領域番号: 07279102
• 研究種目: 重点領域研究
• 配分区分: 補助金
• 研究機関: 大阪大学
• 研究代表者: 津本 忠治 大阪大学, 医学系研究科, 教授 (50028619)
• 研究分担者: 吉岡 亨 早稲田大学, 人間科学部, 教授 (70046027) ; 小幡 邦彦 岡崎共同研究機構, 生理学研究所, 教授 (60013976) ; 村上 富士夫 (村上 冨士夫) 大阪大学, 基礎工学研究科, 教授 (20089882) ; 池中 一裕 岡崎共同研究機構, 生理学研究所, 教授 (00144527) ; 川合 述史 自治医科大学, 医学部, 教授 (00073065)
• 研究期間 (年度): 1995 – 1998
• 研究課題ステータス: 完了 (1999年度)
• 配分額: 90,100千円 (直接経費: 90,100千円); 1999年度: 3,000千円 (直接経費: 3,000千円); 1998年度: 16,000千円 (直接経費: 16,000千円); 1997年度: 19,200千円 (直接経費: 19,200千円); 1996年度: 25,200千円 (直接経費: 25,200千円); 1995年度: 26,700千円 (直接経費: 26,700千円)
• キーワード: 脳 / 神経回路 / 発達 / ニューロン / シナプス / 分化 / 発生 / 可塑性 / 長期増強

研究概要

平成7年度から平成10年度にわたって実施された特定領域研究(A)(1)「神経回路の機能発達」(領域番号356)の計画研究班員及び公募班員の業績リストを作成した。また、各班員から研究成果の報告書を集め、研究成果の取りまとめを行った。458ぺージにわたる研究成果報告書は、単に研究成果のみならず今後の課題や研究遂行上の問題点も記述し、各班員の研究の今後の展開にとっても有意義な報告書となった。また、この研究成果報告書を各班員に配布するとともに研究成果を広く世に問うため関連分野の研究者にも送付した。

研究成果

• [文献書誌] Hata, Y., Ohsima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monoculary deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20(RC57). 1-5 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hata, Y., Tsumoto, T. and Stryker, M.P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E.R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Allen, C., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hata, Y., Ohshima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columuns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20 (RC57). 1-5 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hata, Y., Tsumoto, T. and Stryker, M. P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E. R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Allen, C. N., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hata, Y., Ohshima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20 (RC57). 1-5 (2000)
• [文献書誌] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)
• [文献書誌] Hata, Y., Tsumoto, T. and Stryker, M. P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)
• [文献書誌] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)
• [文献書誌] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E. R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)
• [文献書誌] Allen, C. N., Jiang, Z., Teshima, K., Darkand, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)
• [文献書誌] Kinoshita,S.,Yasuda,H.,Taniguchi,N.et al.: "Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex." J.Neuroscience. 19. 2122-2130 (1999)
• [文献書誌] Hata,Y.,Tsumoto,T.and Stryker,M.P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited." Neuron. 22. 375-381 (1999)
• [文献書誌] Shirasaki,R.,Katsumata,R.and Murakami,F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target." Science. 279. 105-107 (1998)
• [文献書誌] Kojima,N.,Ishibashi,H.,Obata,K.and Kandel,E.R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methy1-D-aspartate receptor subunit 2B in fyn transgenic mice." Leaming & Memory. 5. 429-445 (1998)
• [文献書誌] Miyakawa,T.,Yagi,T.,Kitazawa,H.,Yasuda,M.Kawai,N.et al.: "Fyn-Kinase as a determinant of ethanol sensitivity:Relation to NMDA receptor function." Science. 278. 698-701 (1997)
• [文献書誌] Allen,C.N.,Jiang,Z.,Teshima,K.,Darland,T.,Ikeda,M.et al.: "Orphanin-FQ(OFQ)modulates the activity of suprachiasmatic nucleus neurons." J.Neuroscience. 19. 2152-2160 (1999)
• [文献書誌] Akaneya,T., Tsumoto,T., Kinoshita,S. and Hatanaka,H.: "Brain derived neurotrophic factor enhances long-term potentiation in rat visual cortex." J.Neurosci.17. 6707-6716 (1997)
• [文献書誌] Kimura,F., Otsu,Y. and Tsumoto,T.: "Presynaptically silent synapses : Spontaneously active terminals without stimulus-evoked release demonstrated in cortical autapses." J.Neurophysiol.77. 2805-2815 (1997)
• [文献書誌] Shirasaki,R., Katsumata,R. and Murakami,F.: "Differential chemoattractant sensitivity of commissural axons before and after crossing the floor plate." Science. 279. 105-107 (1998)
• [文献書誌] Saito,Y., Song,W.-J. and Murakami,F.: "Preferential termination of corticorubral axons on spine-like dendritic protrusions in developing cat." J.Neurosci.17. 8792-8803 (1997)
• [文献書誌] Miyakawa,T., Yagi,T., Kitazawa,H., Yasuda,M. Kawai,N. et al.: "Fyn-kinase as a determinant of ethanol sensitivity : Relation to NMDA receptor function." Science. 278. 698-701 (1997)
• [文献書誌] Asada,H., Kawamura,Y. et al.: "Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase." Proc.Natl.Acad.Sci.USA. 94. 6496-6499 (1997)
• [文献書誌] Akaneya,Y.,Tsumoto,T.and Hatanaka,H.: "Long-term depression blocked by brain derived neurotrophic factor in rat visual cortex." J.Neurophysiol.76. 4198-4201 (1996)
• [文献書誌] Tamura,H.,Sato,H.,Katsuyama,N.,et al.: "Less segregated processing of visual information in V2 than in Vl of the monkey visual cortex." Europ.J.Neurosci.8. 300-309 (1996)
• [文献書誌] Yasuda,H.,and Tsumoto,T.: "Long-term depression in visual cortex is associated with a lower rise of postsynaptic Ca2+ than LTP." Neurosci.Res.24. 265-274 (1996)
• [文献書誌] Murakami,F.,Nagisa,Y.,Saito,Y.,Higashi,S.,et al.: "Morphology of individual axons in crossed corticorubral projections in developing cats and effects of partial denervation." Dev.Neurosci.18. 162-173 (1996)
• [文献書誌] Shirasaki,R.,Mirzayan,C.,Tessier-Lavigne,M.,et al.: "Guidance of circumferentially growing axons by netrin-dependent and independent floor plate chemotropism in the vertebrate brain." Neuron. 17. 1079-1088 (1996)
• [文献書誌] Tsubokawa,H,,Oguro,K.,Robinsdon,H.P.C.,et al.: "Intracellular inositol 1,3,4,5-tetrakisphosphate enhances the calcium current in hippocampal CAl neurones of the gerbil followint transient forebrain ischaemia." J.Physiol.Lond.497. 67-78 (1996)
• [文献書誌] Otsu,Y.,Kimura,F.,Tsumoto,T.: "Hebbian induction of LTP in visual cortex: A perforated patch clamp study in cultured neurons." J. Neurophysiol.74. 2437-2444 (1995)
• [文献書誌] Torii,N.,Kamishita,Y.,Otsu,Y.and Tsumoto,T.: "An inhibitor for calcineurin, FK506 blocks induction of long-term depression in rat visual cortex." Neurosci. Lett.185. 1-4 (1995)
• [文献書誌] Shirasaki,R.,Tamada,A.,Katsumata,R.et al.: "Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis." Neuron. 14. 961-972 (1995)
• [文献書誌] Kim,C.S.,Nelson,T.J.,Yoshioka,T. et al.: "Alzheimer and β-amyloid-treated fibroblasts demonstrate a decrease in a memory associated GTP-binding protein, Cp20." Proc. Natl. Acad. Sci. USA. 92. 3060-3064 (1995)
• [文献書誌] Ogawa,M. Miyata,T.,Nakajima,K.,Yagyu,K.,Seike,M.,Ikenaka,K.,et al.: "The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons." Neuron. 14. 899-912 (1995)
• [文献書誌] Yamagata,Y.,Obata,k.,et al.: "Increase in synapsin I phosphorylation implicates a presynaptic component in septal kindling." Neuroscience. 64. 1-4 (1995)