| 研究概要 |
Atelopeptide type I collagen(CL) and porous hydroxyapatile(pHAP) were used as a carrier for heterotopic osteoinduction by BMPs,purified BMP,rhBMP-2 and rxBMP-4/7 heterodimer.
In using CL,purified BMP and rhBMP-2 osteoinduced ectopic bone in rat calf muscle (Kusumoto et al. BBRC 1995). However,massive trabeculum in purified BMP groups and massive marrow in rhBMP-2 groups were induced.
In using CL and pHAP,rhBMP-2 induced ectopicly in rat calf muscle(Kusumoto et al. J Cranio-Maxillofac Surg 1996). Trabeculum was induced in the pores of pHAP,even in the deep pores,and the amount was dependent upon the dosage of rhBMP-2.
In using CL,rhBMP-2 and rxBMP-4/7 heterodimer induced ectopic bone(Kusumoto et al. BBRC 1997). The amount of trabeculum in rhBMP-2 group was more than in rxBMP-4/7 heterodimer. Osteoinducing ability in rhBMP-2 gorup was vigorous than in rxBMP-4/7 heterodimer group.
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