中国海門市における肝がんの生活環境要因に関する研究

• 研究課題/領域番号: 08042010
• 研究種目: 国際学術研究
• 配分区分: 補助金
• 応募区分: がん調査
• 研究機関: 名古屋市立大学
• 研究代表者: 徳留 信寛 名古屋市立大学, 医学部, 教授 (00037441)
• 研究分担者: 兪 順章 上海医科大学, 予防医学研究所, 教授 ; 溝上 雅史 名古屋市立大学, 医学部, 助手 (40166038) ; 小田 秀明 東京大学, 医学部, 助教授 (40214142) ; 上野 芳夫 東京理科大学, 薬学部, 教授 (00084418) ; 原田 健一 名城大学, 薬学部, 助教授 (90103267) ; YU Shun-Zhang Shanghai Medical University・Institute of Preventive Medicine, Professor ; 陳 公超 海門市衛生防疫局, 局長 ; 陳 剛 上海医科大学, 公衆衛生学院, 講師 ; 永谷 照男 名古屋市立大学, 医学部, 講師 (40144018) ; 末岡 榮三朗 埼玉県立がんセンター研究所, 血清ウィルス部, 研究員 (00270603) ; 田代 文夫 東京理科大学, 基礎工学部, 教授 (70089332)
• 研究期間 (年度): 1996
• 研究課題ステータス: 完了 (1996年度)
• 配分額: 5,000千円 (直接経費: 5,000千円); 1996年度: 5,000千円 (直接経費: 5,000千円)
• キーワード: 中国海門市 / 肝がん / 宿主要因 / 生活環境要因 / HBV / マイコトキシン / マイクロシスチン / 疫学 / 宿上要因

研究概要

中国海門市における肝がん発生に関する宿主要因(がん遺伝子・がん抑制遺伝子など)と環境要因(HBV/HCV感染、AFB_1汚染食品摂取、当該地域のクリーク水・溜池水などの飲用、喫煙・飲酒歴など)の関与及びそれら諸要因の交互作用について諸観点から調べ、肝がん発生予防に資する。
【研究対象・材料と方法】
1)クリーク水・溜池水などからMCsの検出を行った。2)食品(とうもろこし、ピ-ナッツなど)を採取して、AFB_1及びその他のマイコトキシンの分析を行った。3)パラフィンブロック標本を利用した肝がん病理学的研究、MCsの検索及びがん遺伝子・がん抑制遺伝子分析を行った。4)肝がん症例群と性・年齢を1:1でマッチさせ、地域住民から無作為抽出した対照群に対して、既往歴・家族歴、AFB_1汚染食品摂取状況、飲料水の種類と飲料状況、喫煙・飲酒歴などに関する面接調査を行い、データの集計には単変量ないし多変量解析を行った。
さらに、肝がん症例群と対照群より血液を採取し、血漿・血清部分を利用してHBV/HCVのマーカー及びサブタイプ、AFB_1アルブミンアダクト、セレニウムなどの微量元素、抗酸化物質、脂肪酸組成、TNF_α活性、神経分化誘導因子などの分析を行った。
【結果と考察】
これまでに飲料水及び環境中のMCsの定性・定量法を開発し、当該地域のクリーク水・溜池水などからMCsを検出した。食品の化学分析では、とうもろこし、ピ-ナッツなどにAFB_1及びその他のマイコトキシン(フモニシンなど)を検出した。当該地域の肝がんパラフィンブロック標本を利用した研究により、AFB_1関連肝がんに特異的なp53変異を見い出した。
症例対照研究(184ペア)では、対照群と比較して症例群に肝疾患既往歴や家族歴があるものが多かったが、AFB_1汚染食品摂取状況については両群間に差異を認めなかった。クリーク水・溜池水などの摂取頻度・摂取期間にも両群間に差異を検出できなかった。症例群に喫煙歴及び飲酒歴が多かったが、その差異は統計学的に有意ではなかった。AFB_1アルブミンアダクトの陽性率は、対照群と比較して症例群に高かったが、統計学的に有意ではなかった。HBV/HCVの血清マーカー及びサブタイプを調べたところ、当該地域にはHCV関連肝がんもあるが、HBV関連のものがメインであった。

研究成果

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• [文献書誌] Ohno, T., Mizokami, M., Tokudome, S.et al.: "Usefulness and limitation of phylogenetic analysis for hepatitis C virus core region : application to isolates from Egyptian and Yemeni patients." Arch.Virol.141. 1101-1113 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
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  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Saku, M., Tokudome, S.et al.: "Mortality in psychiatric patients, with a specific focus on cancer mortality associated with schizophrenia." Int.J.Epidemiol.24. 366-372 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hirose, K., Tokudome, S.et al.: "A large-scale, hospital-based case-control study of risk factors of breast cancer according to menopausal status." Jpn.J.Cancer Res.86. 146-154 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
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  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kondo, F., Harada, K.-I.et al.: "Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers." Chem.Res.Toxicol.9. 1355-1359 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Harada, K.-I.et al.: "Mass spectrometric screening method for microcystins in cyanobacteria." Toxicon. 34. 701-710 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Murata, M., Harada, K.-I.et al.: "High-performance liquid chromatography with chemiluminescence detection of derivatized microcystins." J.Chromatogr.A. 693. 263-270 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kondo, F., Harada, K.-I.et al.: "Reliable and sensitive methodfor determination of microcystins in complicated matrices by frit-fast atom bombardment liquid chromatography/mass spectrometry." Natural Toxins. 3. 41-49 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Harada, K.-I.et al.: "Two cyclic peptides, anabaenopeptins, a third group of bioacitive compounds from the cyanoacterium anabaena flos-aquae NRC 525-17." Teterhedron Lett.36. 1511-1514 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Harada, K.-I.et al.: "A method using LC/MS for determination of absolute configuration of constituent amino acids in peptide Advanced Marfey's method." Teterhedron Lett.36. 1515-1519 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tsuji, K., Harada, K.-I.et al.: "Stability of microcystins from cyanobacteria.II.Effect of UV Light on decomposotion and iso-merization." Toxicon. 33. 1619-1631 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tsuji, K., Harada K.-I.et al.: "A clean-up method for analysis of trace amounts of microcystins in lake water." Toxicon. 32. 1251-1259 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nagata, S., Ueno, Y.et al.: "Enzyme immunoassay for direct determination of microcystins in environmental water." J.AOAC Int.(in press).
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ueno, Y.et al.: "Survey of microcystins in environmental water by a highly sensitive immunoassay based on monoclonal antibody." Natural Toxins. 4. 271-276 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ueno, Y.et al.: "Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay." Carcinogenesis. 17. 1317-1321 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iijima, K., Ueno, Y.et al.: "Development of highly sensitive enzyme-linked immunosorbent assay for fumonisins, and its application for contaminated corn." Mycotoxins. 42. 63-66 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kawamura, O., Ueno, Y.et al.: "Analysis of aflatoxin B_1-human serum albumin adducts by sandwich enzyme-linked immunosorbent assay." Mycotoxins. 43. 43-46 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nagata, S., Ueno.Y.et al.: "Novel monoclonal antibodies against microcystins and their protective activity in the hepatotoxicity." Natural Toxins. 3. 78-86 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ueno, Y.et al.: "Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells." Natural Toxins. 3. 129-137 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Wang, K.-S., Ueno, Y.et al.: "Co-contamination of mycotoxins in corn in Haimen, a high risk area of primary liver cancer in China." Mycotoxins. 41. 67-70 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Wang, D.-S., Ueno, Y.et al.: "Natural occurrence of fusarium mycotoxins and aflatoxin B_1 in corn for feed in north Vietnam." Natural Toxins. 3. 445-449 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iida, N., Tashiro, F.et al.: "Overexpression of c-myc gene is requiried for Tamoxifen-elicited apoptosis in aflatoxin B_1-induced rat hepatoma cells." Res.Comm.Biochem.Cell Mollecul.Biol. (in press).
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iida, N., Tashiro, F.et al.: "Analysis of cell death induced by sodium 5,6-benzylidene-ascorbate in rat hepatoma Kugura-2 cells." Mycotoxins. 42. 35-49 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Takai, R., Tashiro, F.et al.: "Function of RNH-1/14-3-3beta gene in cellular differentiation and proliferation." J.Biochem.118. 1045-1053 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Oda, H.et al.: "A mutational hot spot in the p53 gene is associated with hepatoblastoma." Int.J.Cancer. 60. 788-790 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Suganuma, M., Sueoka, E.et al.: "A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression." Cancer Res.56. 3711-3715 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sueoka, N., Sueoka, E.et al.: "Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression." Carcinogenesis. 17. 2237-2341 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Wu.R.R., Mizokami, M.et al.: "GB virus C/hepatitis G virus infection in Southern China." J.Infect.Dis.175. 168-171 (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Lin, H.H., Mizokami, M.et al.: "Serotypes, genotypes and levels of hepatitis C viremia in pregnant women in Taiwan." J.Formos.Med.Assoc.95. 429-434 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kao, J.H., Mizokami, M.et al.: "Serotyping of hepatitis C virus in chronic type C hepatitis in Taiwan : correlation with genotypes." J.Gastroenterol.31. 224-227 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Doi, H., Mizokami, M.et al.: "Hepatitis C virus (HCV) subtype prevalence in Chiang Mai, Thailand, and identification of novel subtypes of HCV major type 6." J.Clin.Microbiol.34. 569-574 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tahara, T., Mizokami, M.et al.: "Vertical transmission of tepatitis C virus through three generations." Lancet. 347. 409 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Wu, R.-R., Mizokami, M.et al.: "Seroprevalence of hepatitis C virus infection and its phenotype in Lanzhou, Western China." J.Med.Virol.45. 174-178 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ohba, K., Mizokami, M.et al.: "Relationship between hepatitis B virus serotypes and genotypes of hepatitis B virus -genetic classification of HBV by use of surface genes-." Virus Res.39. 25-34 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yu, S.Z.: "The primary prevention of cancer in China." Bull.Chin.Cancer. 6. 6-8 (1997)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Vin, F., Yu, S.Z.et al.: "The toxic dynamics of aflatoxins in rat." Hygienic. Toxic.10. 19-22 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Zhou, W.Z., Yu, S.Z.et al.: "The immunity response of HBV gene vaccination in mice." Shanghai J.Immun.16. 210-212 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Chen, G., Yu, S.Z.et al.: "The survey of microcystins in hyperendemic area of liver cancer." J.Chin.Prev.Med.30. 6-8 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Chen, G., Yu, S.Z.et al.: "The seasonal variation of microcystins in different water sources in hyperendemic area." J.Chin.Epidemiol.16. 117-119 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yu, S.Z.et al.: "The cohort study of primary liver cancer in Nanhui." J.Chin.Epidemiol.16. 22-24 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yu, S.Z.: "Primary prevention of hepatocellular carcinoma." J.Gastroenterol. Hepatol.10. 674-682 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yu, S.Z.: "Preventive medicine and public health." Shanghai Prev.Med.6. 1-3 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Zhao, L., Yu, S.Z.: "The interaction of risk factors of liver cancer" J.Chin.Chron.Dis.Control. Prev.1. 277-280 (1993)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Zhao, L., Yu.S.Z.: "The meta-analysis of ten case-control studies for liver cancer." J.Chin.Public Health. 13. 65-68 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Zhao, L., Yu.S.Z.: "The combining effect of three main risk factors for primary liver cancer." J.Chin.Epidemiol.15. 89-92 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Zhao, L., Chen, G., Yu, S.Z.et al.: "The meta-analysis of risk factors in case-control study for liver cancer." J.Chin.Public Health. 13. 65-67 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Chen, G., Yu, S.Z.et al.: "The relationship between HCV and liver cancer in hyperendemic areas." Chin.J.Cancer. 4. 30-33 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Cova, L., Yu, S.Z.et al.: "Duck hepatitis B virus infection, aflatoxin B_1, and liver cancer in domestic Chinese ducks." Br.J.Cancer. 6. 104-109 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yu, S.Z., Chen, G.: "Blue-green algal toxins and liver cancer" Chin.J.Cancer Res.6. 9-17 (1994)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sueoka, E.et al.: Exression of early response-genes by nodularin, a new type liver carcino gen, through inhibition of protein Phosphatases 1 and 2A.In Harmful and Toxic Algal Blooms (Yasumoto, T.et al.[Eds.]) In tergovernmental Oceanographic Commission of UNESCO 1996. In tergovernmental Oceanographic Commission of UNESCO 1996, Sendai Kyodo Printing Co.Ltd., 483-486 (1996)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sueoka, E.et al.: Expression of early response genes and of tumor necrosis factor-alpha gene by the okadaic acid class tumor promoters in relation to carcinogenesis. In Proceedings of International symposium on Ciguatera and Marine Natural Products (Hokama, Y.et al.[Eds.]). Asian-Pacific Res.Foundation, 183-196 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Fujiki, H., Sueoka, E.et al.: Carcinogenesis of microcystins. In Toxic Microcystis (Watanabe, M.et al.[Eds.]). CRC Press, Inc., 203-232 (1995)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tokudome, S.: "Semen of smokers and cervical cancer risk." J. Natl. Cancer Inst.89. 96-97 (1997)
• [文献書誌] Ohno, T. , Misokami, M. , Tokudome, S. et al.: "Usefulness and limitation of phylogenetic analysis for hepatitis C virus core region : application to isolates from Egyptian and Yemeni patients." Arch. Virol.141. 1101-1113 (1996)
• [文献書誌] Hirose, K. , Tokudome, S. et al.: "Subsite (servix/endometrium) -specific risk and prospective factors in uterus cancer." Jpn. J. Cancer Res.87. 1001-1009 (1996)
• [文献書誌] Saku, M. , Tokudome, S. et al.: "Mortality in psychiatric patients, with a specific focus on cancer mortality associated with schizophrenia." Int. J. Epidemiol.24. 366-372 (1995)
• [文献書誌] Hirose, K. , Tokudome, S. et al.: "A large-scale, hospital-based case-control study of risk factrors of breast cancer according to menopausal status." Jpn. J. Cancer Res.86. 146-154 (1995)
• [文献書誌] Harada, K. I. et al.: "Detection and identification of microcystins in the drinking water of Haimen city. China." Natural Toxins. 4 (in press). (1996)
• [文献書誌] Kondo. F. Harada, K. -1. et al.: "Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers." Chem. Res. Toxicaol.9. 1355-1359 (1996)
• [文献書誌] Harada, K. -1. et al.: "Mass spectrometric screening method for microcystins in cyanobacteria." Toxicon. 34. 701-710 (1996)
• [文献書誌] Murata, M. , Harada. K. -I. et al.: "High-performance liquid chromatography with chemiluminescence detection of derivatized mecrocystins." J. Chromatogr. A. 693. 263-270 (1995)
• [文献書誌] Kondo. F. , Harada. K. -I. et al.: "Reliable and sensitive method for determination of microcystins in complicated matrices by fritfast atom bombarment liwuid chromatography/mass spectrometry." Natural Toxins. 3. 41-49 (1995)
• [文献書誌] Harada, K. -I. et al.: "Two cyclic peptides, anabaenopeptins, a third group of bioacitive compounds from the cyanoacterium anabaena flos-aquae NRC 525-17." Teterhedron Lett.36. 1511-1514 (1995)
• [文献書誌] Harada, K. -I. et al.: "A method using LC/MS for determination of absolute configuration of constituent amino acids in peptide. Advanced Marfey's method." Teterhedron Lett.36. 1515-1519 (1995)
• [文献書誌] Tsuji. K. , Harada, K. -I. et al.: "Stability of microcystins from cyanobacteria. II Effect of UV Light on decomposotion and isomerization." Toxicon. 33. 1619-1631 (1995)
• [文献書誌] Tsuji, K. , Harada K. -I. et al.: "A clean-up method for analysis of trace amounts of microcystins in lake water." Toxicon. 32. 1251-1259 (1994)
• [文献書誌] Nagata, S. , Ueno. V. et al.: "Enzyme immunoassay for direct determination of microcystins in environmental water." J. AOAC Int.80 (in press). (1997)
• [文献書誌] Ueno, Y. et al.: "Survey of microcystins in environmental water by a highly sensitive immunoassay based on monoclonal antibody." Natural Toxins. 4. 271-276 (1996)
• [文献書誌] Ueno. Y. et al.: "Detection of microsystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay." Carcinogenesis. 17. 1317-1321 (1996)
• [文献書誌] 上野芳夫 他.: "天然毒シリーズ:(2)スフィンゴシン類似マイコトキシン、フモニシン." J. Toxicol. Sci.21. App.-27-39 (1996)
• [文献書誌] 飯島一行,上野芳夫 他.: "フモニシンに対する高感度酵素免疫測定法の開発と汚染トウモロコシへの応用." Mycotoxins. 42. 63-66 (1996)
• [文献書誌] 川村 理,上野芳夫 他.: "サンドイッチELISAによるアフラトキシンB_1-ヒト血清アルブミン付加体測定." Mycotoxins. 43. 43-46 (1996)
• [文献書誌] Nagata, S. , Ueno. Y. et al.: "Novel monoclonal antibodies against microcystins and their protective activity in the hepatotoxicity" Natural Toxins. 3. 78-86 (1995)
• [文献書誌] Ueno, Y. et al.: "Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells." Natural Toxins. 3. 129-137 (1995)
• [文献書誌] Wang. D. -S. , Ueno, Y. et al.: "Co-contamination of mycotoxins in corn in Haimen, a high risk area of primary liver cancer in China." Mycotoxins. 41. 67-70 (1995)
• [文献書誌] Wang. D. -S. , Ueno, Y. et al.: "Natural occurrence of fusarium mycotoxins and aflatoxin B_1 in corn for feed in north Vietanam." Natural Toxins. 3. 445-449 (1995)
• [文献書誌] Iida, N. , Tashiro, F. et al.: "Overexpression of c-myc gene is requiried for Tamoxifen-elicited apoptosis in aflatoxin B_1-induced rat hepatoma cells." Res. Comm. Biochem. Cell Mollecular Biol.(in press).
• [文献書誌] Iida N. , Tashiro. F. et al.: "Analysis of cell death induced by sodium 5, 6-benzylidene-asorbate in rat hepatoma Kugura-2 cells." Mycotoxins. 42. 35-49 (1996)
• [文献書誌] Takai, R. , Tashiro. F. et al.: "Function of RNH-1/14-3-3β gene in cellular different-iation and proliferation." J. Biochem.118. 1045-1053 (1995)
• [文献書誌] Oda, H. et al.: "A mutational hot spot in the p53 gene is associated with hepatoblastoma." Int. J. Cancer. 60. 788-790 (1995)
• [文献書誌] Suganuma, M. , Sueoka, E. et al.: "A new process of cancer prevention Mediated through inhibition of tumor necrosis factor a expression." Cancer Res.56. 3711-3715 (1996)
• [文献書誌] Sueoka, N. , Sueoka, E. et al.: "Anti-cancer effects of morphine through inhibition of tumour necrosis factor-α release and mRAN expression." Carcinogenesis. 17. 2237-2341 (1996)
• [文献書誌] Wu. R. R. , Mizokami, M. et al.: "GB virus-C/hepatitis G virus infection in Southern China" J. Intect. Dis.175. 168-171 (1997)
• [文献書誌] Lin, H. H. , Mizokami, M. et al.: "Serotypes, genotypes and levels of hepatitis C viremiea in pregnant women in Taiwan" J. Formos. Med. Assoc.95. 429-434 (1996)
• [文献書誌] Kao, J. H. , Mizokami, M. et al.: "Serotyping of hepatitis C virus in chronic type C hepatitis in Taiwan : correlation with genotypes." J. Gastroenterol.31. 224-227 (1996)
• [文献書誌] Doi. H. , Mizokami, M. et al.: "Hepatitis C virs (HCV) subtype prevalence in Chiang Mai, Thailand, and identification of novel subtypes of HCV major type 6." J. Clin. Microbiol.34. 569-574 (1996)
• [文献書誌] Tahara, T. , Mizokami, M. et al.: "Vertical transmission of hepatitis C virus through three generations." Lancet. 347. 409- (1996)
• [文献書誌] Wu. R. -R. , Mizokami, M. et al.: "Seroprevalence of hepatitis C virus infection and its fenotype in Lanzhou, Western China." J. Med. Virol.45. 174-178 (1995)
• [文献書誌] Ohba, K. , Mizokami, M. et al.: "Relationship between hepatitis B virus serotypes and genotypes of hepatitis B virus-genetic classification of HBV by use of surface genes-." Virus Res.39. 25-34 (1995)
• [文献書誌] Yu, S. Z.: "The primary prevention of cancer in China." Bull. Chin. Cancer. 6 (1). 6-8 (1997)
• [文献書誌] Yin, F. , Yu, S. Z. et al.: "The toxic dynamics fo aflatoxins in rat." Hygienic. Toxic.10 (1). 19-22 (1996)
• [文献書誌] Zhou, W. Z. , Yu, S. Z. et al.: "The immunity response of HBV gene vaccination in mice." Shanghai J. Immun.16 (4). 210-212 (1996)
• [文献書誌] Chen, G. , Y. S. Z. et al.: "The survey fo microsystins in hyper endemic area of liver cancer." J. Chin. Prev. Med.30. 6-8 (1996)
• [文献書誌] Chen, G. , Yu, S. Z. et al.: "The seasonal variation of microsystins in different water sources in hyperendemic area." J. Chin. Epidemiol.16. 117-119 (1995)
• [文献書誌] Yu, S. Z. et al.: "The cohort study of primary liver cancer in Nanhui." J. Chin. Epidemiol.16. 22-24 (1995)
• [文献書誌] Yu. S. Z.: "Primary prevention of hepatocellular carcinoma." J. Gastroenterol. Hepatol.10. 674-682 (1995)
• [文献書誌] Yu, S. Z.: "Preventive medicine and public health." Shaghai Prev. Med.6 (3). 1-3 (1994)
• [文献書誌] Zhao, L. , Yu, S. Z.: "The interaction of risk factors of liver cancer." J. Chin. Chron. Dis. Control. Prev.1 (6). 277-280 (1993)
• [文献書誌] Zhao, L. , Yu, S. Z.: "The meta-analysis of ten case-control studies for liver cancer." J. Chin. Public Health. 13 (2). 65-68 (1994)
• [文献書誌] Zhao, L. , Yu, S. Z.: "The combining effect of three main risk factors for primary liver cancer." J. Chin. Epidemiol.15 (2). 89-92 (1994)
• [文献書誌] Zhao, L. , Chen, G. , Yu, S. Z. et al.: "The meta-analysis of risk factors in case-control study for liver cancer." J. Chin. Public Health. 13. 65-67 (1994)
• [文献書誌] Chen, G. , Yu, S. Z. et al.: "The relationship between HCV and liver cancer in hyperendemic areas." Chin. J. Cancer. 4. 30-33 (1994)
• [文献書誌] Cova, L. , Yu, S. Z. et al.: "Duck hepatitis B virus infection, aflatoxin B_1, and liver cancer in domestic Chinese Ducks." Br. J. Cancer. 6. 104-109 (1994)
• [文献書誌] Yu. S. Z. , Chen, G.: "Blue-green algal toxins and liver cancer." Chin. J. Cancer Res.6. 9-17 (1994)
• [文献書誌] Sueoka, E. et al.: "Expression of early response genes and of tumor necrosis factor-α gene by the okadaicacid class tumor promoters in relation to carcinogenesis. in Proceedings of International symposium on ciguatera and marine naturalproducts (Eds. Hokama, Y. et al.)" Asian-Pacific Res. Foundation, 12 (1995)
• [文献書誌] Fujiki, H. , Sueoka, E. et al.: "Chapter 9 : Carcinogenesis of microcystins. in Toxic Microcystis (Eds. Watanabe, M. et al." CRC Press. Inc., 29 (1995)
• [文献書誌] 渡辺真利代、原田健一、藤木博太: "アオコ その出版と毒素" 東京大学出版会, 257 (1994)