肝細胞癌の発生・進展における腫瘍血管構築の分子機構と血流画像

• 研究課題/領域番号: 10470143
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 消化器内科学
• 研究機関: 近畿大学
• 研究代表者: 工藤 正俊 近畿大学, 医学部・附属病院 (10298953)
• 研究期間 (年度): 1998 – 2000
• 研究課題ステータス: 完了 (2000年度)
• 配分額: 8,000千円 (直接経費: 8,000千円); 2000年度: 2,000千円 (直接経費: 2,000千円); 1999年度: 2,300千円 (直接経費: 2,300千円); 1998年度: 3,700千円 (直接経費: 3,700千円)
• キーワード: 肝細胞癌 / 腫瘍血管 / 血管新生 / 血流動態 / 多中心性発癌 / ハーモニックイメージング / 血管構築 / 血管新生因子 / 分子機構 / 腫瘍血流 / 血流画像 / 画像診断 / 肝発癌

研究概要

1.肝細胞癌の発癌進展に伴う血流動態の変化
肝細胞癌の発癌初期には結節は過形成として発癌して発癌するが、動脈血流は低下し門脈血流は保たれることを示した。その後、動脈も門脈も低下する時期を経て動脈性腫瘍血管の新生が誘導されて典型的な動脈優位の肝細胞癌へと発育・進展することをinvivo血流イメージングにより示した。またその変化は病理学的進展、あるいは分子生物学的な血管新生因子の誘導ともよく一致した。
2.血流画像的解析
超音波造影剤を用いてハーモニックイメージを行うことにより、上記の血流動態の推移も容易に把握しうることを示した。

研究成果

• [文献書誌] Kudo M: "Morphological diagnosis of hepalocellular carcinoma : special emphais on intranodular hemodynamic imaging."Hepato-Gastroenterology. 45. 1226-1231 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yamamoto T, Kudo M, et al.: "Hepatocellular carcinomas intected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kim SR, Kudo M, et al.: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Watanabe T, Kudo M, et al.: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tochi H, Kudo M, et al.: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall"AJR. 172. 1249-1253 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yamamoto T, Kudo M, et al.: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis Bvirus DNA."Hepatology. 29. 1446-1452 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Liver Radiological Examination- Ultrasonography (including Biopsy), In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyioannis NE."Medic-Online, Euromiltimedia S.A, Luxembourg. (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Marusawa H, Kudo M, et al.: "High prevalence of hepatitis B virus serological markers in patients. with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Watanabe T, Kudo M, et al.: "Cronkhite-Canada syndrome associated with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Watanabe T, Kudo M, et al.: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kim SR, Kudo M, et al.: "Intlammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kim SR, Kudo M, et al.: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three years with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Nakaoka R, Kudo M, et al.: "Repeated hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kim SR, Kudo M, et al.: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Nomura H, Kudo M, et al.: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ding H, Kudo M, et al.: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kawasaki T,Kudo M, et al.: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol. 16(in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kimu SR, Kudo M, et al.: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kawasaki T,Kudo M, et al.: "A case of localized primary sclerosing cholangitis mimicking interahepatic bile duct cancer."Hepatology Research. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ding H, Kudo M, et al.: "Detection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ding H, Kudo M, et al.: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging."JCU. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease with potential risk due to increase in size and number."J Gastroenterol. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology. (in press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Advances in diagnostic imaging of the hepatocellular carcinoma. In "Hepatology in the 21st Century : Diagnosis and Therapy.""IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK. 9 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors. In Dynamic Study of Efferent Tumor Blood Fow"BRACCO, Italy, 2001 (in Press). (2001)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kudo M: "Morphological diagnosis of hepatocellular carcinoma : special emphasis on intranodular hemodynamic imaging"Hepato-Gastroenterology. 45. 1226-1231 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yamamoto T, Kudo M, et al: "Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kim SR, Kudo M, et al: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Watanabe T, Kudo M, et al: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tochio H, Kudo M, et al: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall : evaluation by color Doppler sonography."AJR. 172. 1249-1253 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yamamoto T, Kudo M, et al: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Liver Radiological Examination- Ultrasonography(including Biopsy)"In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyiannis NE, Yamada R, Itai Y, Meyers M, Nolan D, Ros P, Stevenson G, eds., Medic-Online, Euromultimedia S.A., Luxembourg. (http : //medic-online.net). (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Marusawa H, Kudo M, et al: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Watanabe T, Kudo M, et al: "Cronkhite-Canada syndrome with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Watanabe T, Kudo M, et al: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kim SR, Kudo M, et al: "Inflammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kim SR, Kudo M, et al: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three year with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Advances in diagnostic imaging of hepatocellular carcinoma. In "Hepatology in the 21st Century : Diagnosis and Therapy." Tanikawa K, Kojiro M, Gollan J, eds."IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK, IASL Publ, Fukuoka, 2000. 43-51 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nakaoka R, Kudo M, et al: "Repeatted hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kim SR, Kudo M, et al: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nomura H, Kudo M, et al: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets of absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ding H, Kudo M, et al: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kawasaki T, Kudo M, et al: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol. 16(in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kim SR, Kudo M, et al: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kawasaki T, Kudo M, et al: "A case of localized primary sclerosing cholangitis mimicking intrahepatic bile duct cancer."Hepatology Research. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ding H, Kudo M, et al: "Detection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ding H, Kudo M, et al: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging"J Clin Ultrasound. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease will potential risk due to increase in size and number."J Gastroenterol. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology. (in presss). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors."In Dynamic Study of Efferent Tumor Blood Fow, Itai Y, Miura Y, eds, BRACCO, Italy. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ding H, Kudo M, et al: "Detection of intratumoral parenchymal flow in hepatic tumors : value of second harmonic imaging with a Galactose-based contrast agent."Hepatology Research. (in press). (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kudo M: "Morphological diagnosis of hepatocellular carcinoma : special emphais on intranodular hemodynamic imaging."Hepato-Gastroenterology. 45. 1226-1231 (1998)
• [文献書誌] Yamamoto T,Kudo M, et al.: "Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)
• [文献書誌] Kim SR,Kudo M, et al.: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)
• [文献書誌] Watanabe T,Kudo M, et al.: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)
• [文献書誌] Tochio H,Kudo M, et al.: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall"AJR. 172. 1249-1253 (1999)
• [文献書誌] Yamamoto T,Kudo M, et al.: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)
• [文献書誌] Kudo M: "Liver Radiological Examination-Ultrasonography (including Biopsy), In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyiannis NE."Medic-Online, Euromultimedia S.A., Luxembourg. (1999)
• [文献書誌] Marusawa H,Kudo M, et al.: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)
• [文献書誌] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant /borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)
• [文献書誌] Watanabe T,Kudo M, et al.: "Cronkhite-Canade syndrome associated with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)
• [文献書誌] Watanabe T,Kudo M, et al.: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)
• [文献書誌] Kim SR,Kudo M, et al.: "Intlammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)
• [文献書誌] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)
• [文献書誌] Kim SR,Kudo M, et al.: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three years with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)
• [文献書誌] Nakaoka R,Kudo M, et al: "Repeated hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)
• [文献書誌] Kim SR,Kudo M, et al.: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)
• [文献書誌] Nomura H,Kudo M, et al.: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets of absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)
• [文献書誌] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)
• [文献書誌] Ding H,Kudo M, et al.: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR.. (in press). (2001)
• [文献書誌] Kawasaki T,Kudo M, et al.: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol 16 :.. 16(in press). (2001)
• [文献書誌] Kim SR,Kudo M, et al.: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research.. (in press). (2001)
• [文献書誌] Kawasaki T,Kudo M, et al.: "A case of localized primary sclerosing cholangitis mimicking intrahepatic bile duct cancer."Hepatology Research.. (in press). (2001)
• [文献書誌] Ding H,Kudo M, et al.: "Delection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology.. (in press). (2001)
• [文献書誌] Ding H,Kudo M, et al.: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging."JCU.. (in press). (2001)
• [文献書誌] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease with potential risk due to increase in size and number."J Gastroenterol.. (in press). (2001)
• [文献書誌] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol.. (in press). (2001)
• [文献書誌] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology.. (in press). (2001)
• [文献書誌] Kudo M: "Advances in diagnostic imaging of hepatocellular carcinoma.In "Hepatology in the 21st Century : Diagnosis and Therapy.""IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK. 9 (2000)
• [文献書誌] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors.In Dynamic Study of Efferent Tumor Blood Fow"BRACCO, Italy, 2001 (in press). (2001)
• [文献書誌] Tochio H,Kudo M,et al: "Assciation between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gall bladder"AJR. 172. 1249-1253 (1999)
• [文献書誌] Yamamoto T,Kudo M,et al: "Determination of the clonal origin of mulfiple human hepatocellular carcinomas by cloning and PCR of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)
• [文献書誌] Marusawa,Kudo M,et al: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver ***arse in Japan"Gut. 45. 284-288 (1999)
• [文献書誌] Kudo M: "Imaging diagnosis of hepatocellular carcinona and premalignant/borderline lesions."Sewinors in Liver Disease. 19. 297-309 (1999)
• [文献書誌] Watanabe T,Kudo M,et al: "Cronkhite-Canada syndrome associated with triple gastric cansers"Gastrointest Endoscopy. 50. 688-691 (1999)
• [文献書誌] Watanabe T,Kudo M,et al: "Massire rectal bleeding due to ileal tuberculosis"J Gastroenterol. 34. 525-529 (1999)
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