転座関連遺伝子変異を指標とした間期核FISH方による悪性リンパ腫の病型診断

• 研究課題/領域番号: 10670962
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 血液内科学
• 研究機関: 京都府立医科大学
• 研究代表者: 谷脇 雅史 京都府立医科大学, 医学部, 講師 (80163640)
• 研究分担者: 奥田 司 京都府立医科大学, 医学部, 講師 (30291587)
• 研究期間 (年度): 1998 – 1999
• 研究課題ステータス: 完了 (1999年度)
• 配分額: 3,400千円 (直接経費: 3,400千円); 1999年度: 500千円 (直接経費: 500千円); 1998年度: 2,900千円 (直接経費: 2,900千円)
• キーワード: lymphoma / oncogene / IgH gene / FISH / diagnosis / MALTI gene / MALT1 gene

研究概要

免疫グロブリンH(IgH)鎖遺伝子とリンパ腫関連遺伝子をプローブにして,間期核double-color FISH(DC-FISH)法によって非ホジキンリンパ腫173例を検索し、70例(40.5%)にIgH転座を検出した.うち52例(74.3%)で相手遺伝子が同定でき,BCL2 19例,BCL6 16例,BCL1 11例,c-MYC 7例,PAX-5 2例であった.3例で同時に2つの相手遺伝子が見だされ、一方はc-MYCで,他方はBCL1,BCL2,BCL6であった.いずれも治療抵抗性で,白血化と髄膜浸潤を認めた.転座相手が不明の14q+をspectral karyotyping法で解析し,t(10 ; 14)を2例,t(2 ; 14)と11q13を切断点としないt(11 ; 14)を各1例,同定できた.マントル細胞リンパ腫の5例はすべてBCL1/lgH転座が陽性であり,PAX-5/IgH転座陽性の2例はlymphoplasmachtoid lymphomaであった.lgH転座相手をFISGで検出することによって,REAL分類によるリンパ腫の診断を正確に行うことができると考えられる.
次に,MALTリンパ腫に特異的なt(11 ; 18)の18q21からMALT1を単離した.MALT1はリンパ造血細胞に優位に発現、免疫グロブリンのスーパーファミリーに属する構造を持ち,接着分子として機能している可能性がある.MALT1領域と11q21をカバーするYACをプローブにするDC-FISHによって,t(11 ; 18)を間期核で検出する方法を確立した.B-NHL39例のうち4例(肺MALT リンパ腫3例と胃MALTリンパ腫1例)と,12例のマクログロブリン血症のうち1例でt(11 ; 18)を検出した.MALTリンパ腫では染色体分析が困難な場合が多く,今回開発した間期核FISH法は迅速な染色体遺伝子診断法として応用できる.

研究成果

• [文献書誌] Miwa H: "Induction of chromosomal aberrations and growth-transformation of lymphoblastoid cell lines by inhibition of reactive oxygen species-induced apoptosis with interleukin-6"Lab Invest. (in press).
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hosokawa Y: "The lkaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3 ; 7)(q27 ; p12) translocation in a patient with diffuse large B-cell lymophoma"Blood. (in press).
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Nakazawa N: "Interphase detection of t(4 ; 14)(p16.3 ; q32. 3) by in situ hybridization and FGFR3 overexpression in plasma cell malignancies"Gancer Genet Cytogenet. (in press).
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Shimizu S: "Identification of breakpoint cluster regions at 3q21 and 1p36.3 in hematological malignancies with t(1 ; 3)(p36 ; q21)"Genes Chromosomes Cancer. 27. 229-238 (2000)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Taki T: "AF5q31, a new member of the AF-4related genes, is fused to MILL in finfant acute lymphoblastic leukemia with ins(5 ; 11)(q31 ; q13q23)"Proc Natl Acad Sci USA. 96. 14535-14540 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Sakakura C: "Bowel perforation during chmotherapy for non-hodgkin's lymphoma"Hepatogastroenterol. 46. 3175-3177 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Sasai Y: "Genotype of glutathione S-transferase and other genetic configurations in myelodysplasia"Leukemia Res. 23. 975-981 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hamaguchi H: "A new translocation, t(2 ; 4 ; 12)(p21 ; q12 ; p13), in CD7-positive acute myeloid leukemia : A variant form of t(4 ; 12)"Cancer Genet Cytogenet. 114. 96-99 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yoshida S: "Detection of MUM1/IRF4-IgH fusion in multiple myeloma"Leukemia. 13. 1812-1816 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kakazu N: "Combined spectral karyotyping and DAPI-banding analysis of chromosome abnormalitiesin myelodysplastic syndrome"Genes Chromosomes Cancer. 26. 336-345 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Sonoki T: "A Plasma cell leukemia patientshowing bialleic 14q translocations : t(2 ; 14) and t(11 ; 14)"Acta Hematol(Basel). 101. 197-210 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Akagi T: "A novel gene, MALT1 at 18q21, is involved in t(11 ; 18)(q21 ; q21) found in low-grade B-cell lymphoma of mucosa -associated lymphoid tissue"Oncogene. 18. 5785-5794 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Suzukawa K: "Activation of EVL1 transcripts with chromosomal translocation joining the TCRVβlocus and the EVI1 gene in human acute undifferentiated leukemia cell line(Kasumi-3) with a comples translocation of der(3)t(3 ; 7 ; 8)"Leukemia. 13. 1359-1366 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Hirawake H: "Characterization of the human SDHD encoding the small subunit of cytochrome b(sybS) in mitochondrial succinate-ubi1uinone oxidoreducatase"Biochim Biophys Acta. 1412. 295-300 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Nakamura T: "DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon injured arteries"J Biol Chem. 274. 22476-22483 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Horiike S: "Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of nos. 5 and/or 7, and its possible relationship to replication error phenotype"Leukemia. 13. 1235-1242 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kobayashi M: "Identification of photoreceptor cell-specific nuclear receptor"Proc Natl Acad Sci USA. 96. 4814-4819 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Lopez ND: "Isoform specific expression of the SDR-1 protein, α and βin subregions of adult rodent brain"Biomedical Res. 20. 43-49 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Narita M: "Consistent detection of CALM-AF10 chimeric transcripts in haematological malignancies with(10 ; 119(p13 ; q14)and identification of novel transcripts"Brit J Haematol. 105. 928-937 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yashige H: "Micronuclei and nuclear abnormalities observed in erythroblasts in myelodysplastic syndromes and in de novo acute leukemia after treatment"Acta Haematol(Basel). 101. 32-40 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Akagi T: "Cytogenetic analysis of the brealpoint at 18q21.1 in low-grade B-cell lymphoma of mucosa-associated lymhoid tissue"Genes Chromosomes Cancer. 24. 315-321 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Iwai T: "Internal tandem dupliation of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia"Leukemia. 13. 38-43 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tani S: "Chromosomal mapping of two RBP-J-related genes : Kyo-T and RBP-L"J Hum Genet. 44. 73-75 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Sonoki T: "Amplification and overexpression of the PRAD1/Cyclin D1 gene in a multiple myeloma cell line"Int J Hematol. 68. 459-461 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Iwai T: "Frequent aberration of FHIT gene expression in acute leukemia"Cancer Res. 56. 5182-5187 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Ohmori M: "A novel mature B-cell line (DOBIL-6) producing both parathyroid hormone-related protein and interleukin-6 from a myeloma patient presenting with hypercalcaemia"Brit H Haematol. 101. 688-693 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Taki T: "ABI-1, a human homolog to a mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10 ; 11)(p11.2 ; q23)"Blood. 92. 1125-1130 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Tamura A: "Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multipe YAC clones"Int J Cancer. 78. 100-105 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yamamoto K: "A variant Burkitt-type translocation (8 ; 22)(q24; q11) in multiple myeloma"Cancer Genet Cytogenet. 104. 98-103 (1999)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yamamoto K: "A new complex translocation (15 ; 20 ; 17)(q22 ; p13 ; q21) in acute promyelocytic leukemia"Cancer Genet Cytogenet. 101. 89-94 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kojima K: "Trisomy 12 and t(14 ; 18) in B-cell chronic lymphocytic leukemia"Int J Hematol. 67. 199-203 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yabe D: "Human calumenin gene (CALU) : cDNA isolation and chromosomal mapping to 7q32"Genomics. 49. 331-333 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kaneko H: "Rare flteraton of genomic structure of the DPC4 gene in myelogenous leukemias"Acta Haematol(Basel). 99. 187-190 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Fujimaki K: "The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon"Biochemistry. 37. 6838-6846 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Misawa S: "Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia"Leukemia Res. 22. 631-637 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Otsuki T: "Establishment of a new human myeloma cell line. KMS-18, having t(4 ; 14)(p16.3 ; q32.3) derived from a case phenotypically transformed from IgA-λ to BJP-λ, and associated with hyperammonemia"Int J Oncol. 12. 545-552 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Yatabe Y: "Multiple polypoid lesions of primary mucosa-associated lymhoid-tissue lymphoma of colon"Histopathology. 32. 116-125 (1998)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Miwa H. et al.: "Induction of chromosomal aberrations and growth-transformation of lymphoblastoid cell lines by inhibition of reactive oxygen species-induced apoptosis with interleukin-6"Lab Invest. in press.
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hosokawa Y. et al.: "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3 ; 7)(q27 ; p12) translocation in a patient with diffuse large B-cell lymophoma"Blood. in press.
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nakazawa N. et al.: "Interphase detection of t(4 ; 14)(p16.3 ; q32.3) by in situ hybridization and FGFR3 overexpression in plasma cell malignancies"Cancer Genet Cytogenet. in press.
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Shimizu S. et al.: "Identification of breakpoint cluster regions at 3q21 and 1p36.3 in hematological malignancies with t(1 ; 3)(p36 ; q21)"Genes Chromosomes Cancer. 27(3). 229-238 (2000)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Taki T. et al.: "AF5q31, a new member of the AF4-related genes, is fused to MLL in infant acute lymphoblastic leukemia with ins(5 ; 11)(q31 ; q13q23)"Proc Natl Acad Sci USA. 96(25). 14535-14540 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sakakura C. et al.: "Bowel perforation during chemotherapy for non-hodgkin's lymphoma"Hepatogastroenterol. 46(30). 3175-3177 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sasai Y. et al.: "Genotype of glutathione S-transferase and other genetic configurations in myelodysplasia"Leukemida Ras. 23(11). 975-981 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hamaguchi H. et al.: "A new translocation, t(2 ; 4 ; 12)(p21 ; q12 ; p13), in CD7-positive acute myeloid leukemia ; a variant form of t(4 ; 12)"Cancer Genet Cytogenet. 114(2). 96-99 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yoshida S. et al.: "Detection of MUM1/IRF4-lgH fusion in multiple myeloma"Leukemia. 13(11). 1812-1816 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kakazu N. et al.: "Combined spectral karyotyping and DAPI-banding analysis of chromosome abnormalities in myelodysplastic syndrome"Genes Chromosomes Cancer. 26(4). 336-345 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sonoki T. et al.: "A plasma cell leukemia patient showing bialleic 14q translocations : t(2 ; 14) and t(11 ; 14)"Acta Haemato (Basel). 101(4). 197-201 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Akagi T. et al.: "A novel gene,MALT1 at 18q21, is involved in t(11 ; 18)(q21 ; q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue"Oncogene. 18(42). 5785-5794 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Suzukawa K. et al.: "Activation of EVI1 transcripts with chromosomal translocation joining the TCRVβ locus and the EVI1 gene in human acute undifferentiated leukemia cell line (Kasumi-3) with a complex translocation of der(3)t(3 ; 7 ; 8)"Leukemia. 13(9). 1359-1366 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Hirawake H., Taniwaki M., Tamura A., Amino H., Tomitsuka E., Kita K.,: "Characterization of the human SDHD encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate-ubiquinone oxidoreductase"Biochim Biophys Acta. 1412(3). 295-300 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Nakamura T. et al.: "DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon injured arteries"J Biol Chem. 274(32). 22476-22483 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Horiike S. et al.: "Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of nos. 5 and/or 7, and its possible relationship to replication error phenotype"Leukemia. 13(8). 1235-1242 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kobayashi M. et al.: "Identification of a photoreceptor cell-specific nuclear receptor"Proc Natl Acad Sci USA. 96(9). 4814-4819 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Lopez ND. Et al.: "Isoform specific expression of the SDR-1 protein, α and β in subregions of adult rodent brain"Biomedical Res. 20(1). 43-49 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Narita M. et al.: "Consistent detection of CALM-AF10 chimeric transcripts in haematological malignancies with t(10 ; 11)(p13 ; q14) and identification of novel transcript"Brit J Haematol. 105(4). 928-937 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yashige H. et al.: "Micronuclei and nuclear abnormalities observed in erythroblasts in myelodysplastic syndromes and in de novo acute leukemia after treatmen"Acta Haematol (Basel). 101(1). 32-40 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Akagi T. et al.: "Cytogenetic analysis of the breakpoint at 18q21.1 in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue"Genes Chromosomes Cancer. 24(4). 315-321 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iwai T. et al.: "Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia"Leukemia. 13(1). 38-43 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tani S. et al.: "Chromosomal mapping of two RBP-J-related genes : Kyo-T and RBP-L"J Hum Genet. 44(1). 73-75 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sonoki T. et al.: "Amplification and overexpression of the PRAD1/Cyclin D1 gene in a multiple myeloma cell line"Int J Hematol. 68(4). 459-461 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iwai T et al.: "Frequent aberration of FHIT gene expression in acute leukemia"Cancer Res. 56(22). 5182-5287 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ohmori M. et al.: "A novel mature B-cell line (DOBIL-6) producing both parathyroid hormone-related protein and interleukin-6 from a myeloma patient presenting with hypercalcaemia"Brit J Haematol. 101(4). 688-693 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tamura A. et al.: "Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multiple YAC clones"Int J Cancer. 78(1). 100-105 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yamamoto K et al.: "A variant Burkitt-type translocation (8 ; 22)(q24 ; q11) in multiple myeloma"Cancer Genet Cytogenet. 104(2). 98-103 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yamamoto K. et al.: "A new complex translocation (15 ; 20 ; 17)(q22 ; p13 ; q21) in acute promyelocytic leukemia"Cancer Genet Cytogenet. 101(2). 89-94 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kojima K. et al.: "Trisomy 12 and t(14 ; 18) in B-cell chronic lymphocytic leukemia"nt J Hematol. 67(2). 199-203 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Taki T. et al.: "ABI-1, a human homolog to a mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10 ; 11)(p11.2 ; q23)"Blood. 92(4). 1125-1130 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yabe D. et al.: "Human calumenin gene (CALU) : cDNA isolation and chromosomal mapping to 7q32"Genomics. 49(2). 331-333 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kaneko H. et al.: "Rare alteration of genomic structure of the DPC4 gene in myelogenous leukemias"Acta Haematol (Basel). 99(4). 187-190 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Fujimaki K. et al.: "The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon"Biochemistry. 37(19). 6838-6846 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Lopez ND et al.: "Isoform specific expression of the SDR-1 protein, α and βin subregions of adult rodent brain"Biomedical Res. 20(1). 43-49 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Narita M. et al.: "Consistent detection of CALM-AF10 chimeric transcripts in haematological malignacies with t(10 ; 11)(p13 ; q14) and identification of novel trahscript"Brit J Haematol. 105(4). 928-937 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yashige H. et al.: "Micronuclei and nuclear abnormalities observed in erythroblasts in myelodysplastic syndromes and in de novo acute leukemia after treatmen"Acta Haemato (Basel). 101(1). 32-40 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Akagi T. et al.: "Cytogenetic analysis of the breakpoint at 18q21.1 in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue"Genes Chromosomes Cancer. 24(4). 315-321 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iwai T. et al.: "Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia"Leukemia. 13(1). 38-43 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tani S. et al.: "Chromosomal mapping of two RBP-J-related genes : Kyo-T and RBP-L"J Hum Genet. 44(1). 73-75 (1999)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Sonoki T. et al.: "Amplification and overexpression of the PRAD1/Cyclin D1 gene in a multiple myeloma cell line"Int J Hematol. 68(4). 459-461 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Ohmori M. et al.: "A novel mature B-cell line (DOBIL-6) producing both parathyroid hormone-related protein and interleukin-6 from a myeloma patient presenting with hypercalcaemia"Brit J Haematol. 101(4). 688-693 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Taki T. et al.: "ABI-1, a human homolog to a mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10 ; 11)(p11.2 ; q23)"Blood. 92(4). 1125-1130 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Tamura A. et al.: "Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multiple YAC clones"Int J Cancer. 78(1). 100-105 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yamamoto K. et al.: "A variant Burkitt-type translocation (8 ; 22)(q24 ; q11) in multiple myeloma"Cancer Genet Cytogenet. 104(2). 98-103 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Iwai T. et al.: "Frequent aberration of FHIT gene expression in acute leukemia"Cancer Res. 56(22). 5182-5187 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yamamoto K. et al.: "A new complex translocation (15 ; 20 ; 17)(q22 ; p13 ; q21) in acute promyelocytic leukemia"Cancer Genet Cytogenet. 101(2). 89-94 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kojima K. et al.: "Trisomy 12 and t(14 ; 18) in B-cell chronic lymphocytic leukemia"Int J Hematol. 67(2). 199-203 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yabe D. et al.: "Human calumenin gene (CALU) : cDNA isolation and chromosomal mapping to 7q32"Genomics. 49(2). 331-333 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Kaneko H. et al.: "Rare alteration of genomic structure of the DPC4 gene in myelogenous leukemias"Acta Haematol (Basel). 99(4). 187-190 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Fujimaki K. et al.: "The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon"Biochemistry. 37(19). 6838-6846 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Misawa S. et al.: "Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia"Leukemia Res. 22(7). 631-637 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Otsuki T. et al.: "Establishment of a new human myeloma cell line, KMS-18, having t(4 ; 14)(p16.3 ; q32.3) derived from a case phenotypically transformed from lgA-λ to BJP-λ, and associated with hyperammonemia"Int J Oncol. 12(3). 545-552 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Yatabe Y. et al.: "Multiple polypoid lesions of primary mucosa-associated lymphoid-tissue lymphoma of colon"Histopathology. 32(2). 116-125 (1998)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Miwa H: "Induction of chromosomal aberrations and growth-transformation of lymphoblastoid cell lines by inhibition of reactive oxygen species-induced apoptosis with interleukin-6"Lab Invest. (in press).
• [文献書誌] Hosokawa Y: "The Ikaros gene,a central regulator of lymphoid differentiation,fuses to the BCL6 gene as a result of t(3;7)(q27;p12)translocation in a patient with diffuse large B-cell lymophoma"Blood. (in press).
• [文献書誌] Nakazawa N: "Interphase detection of t(4;14)(p16.3;q32.3)by in situ hybridization and FGFR3 overexpression in plasma cell malignancies"Cancer Genet Cytogenet. (in press).
• [文献書誌] Shimizu S: "Identification of breakpoint cluster regions at 3q21 and 1p36.3 in hematological malignancies with t(1;3)(p36;q21)"Genes Chromosomes Cancer. 27・3. 229-238 (2000)
• [文献書誌] Taki T: "AF5q31,a new member of the AF4-related genes,is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)"Proc Natl Acad Sci USA. 96・25. 14535-14540 (1999)
• [文献書誌] Sakakura C: "Bowel perforation during chemotherapy for non-hodgkin's lymphoma"Hepatogastroenterol. 46・30. 3175-3177 (1999)
• [文献書誌] Sasai Y: "Genotype of glutathione S-transferase and other genetic configurations in myelodysplasia"Leukemia Res. 23・11. 975-981 (1999)
• [文献書誌] Hamaguchi H: "A new translocation,t(2;4;12)(p21;q12;p13),in CD7-positive acute myeloid leukemia:A variant form of t(4;12)"Cancer Genet Cytogenet. 114・2. 96-99 (1999)
• [文献書誌] Yoshida S: "Detection of MUM1/IRF4-IgH fusion in multiple myeloma"Leukemia. 13・11. 1812-1816 (1999)
• [文献書誌] Kakazu N: "Combined spectral karyotyping and DAP1-banding analysis of chromosome abnormalities in myelodysplastic syndrome"Genes Chromosomes Cancer. 26・4. 336-345 (1999)
• [文献書誌] Sonoki T: "A plasma cell leukemia patient showing bialleic 14q translocations:t(2;14)and t(11;14)"Acta Haematol(Basel). 101・4. 197-201 (1999)
• [文献書誌] Akagi T: "A novel gene,MALT1 at 18q21,is involved in t(11;18)(q21;q21)found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue"Oncogene. 18・42. 5785-5794 (1999)
• [文献書誌] Suzukawa K: "Activation of EVl1 transcripts with chromosomal translocation joining the TCRVβ locus and the EVl1 gene in human acute undifferentiated leukemia cell line(Kasumi-3)with a complex translocation of der(3)t(3;7;8)"Leukemia. 13・9. 1359-1366 (1999)
• [文献書誌] Hirawake H: "Characterization of the human SDHD encoding the small subunit of cytochrome b(cybS)in mitochondrial succinate-ubiquinone oxidoreductase"Biochim Biophys Acta. 1412・3. 295-300 (1999)
• [文献書誌] Nakamura T: "DANCE,a novel secreted RGD protein expressed in developing,atherosclerotic,and balloon injured arteries"J Biol Chem. 274・32. 22476-22483 (1999)
• [文献書誌] Horiike S: "Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of nos.5 and/or 7,and its possible relationship to replication error phenotype"Leukemia. 13・8. 1235-1242 (1999)
• [文献書誌] Kobayashi M: "Identification of a photoreceptor cell-specific nuclear receptor"Proc Natl Acad Sci USA. 96・9. 4814-4819 (1999)
• [文献書誌] Lopez ND: "Isoform specific expression of the SDR-1 protein,α and β in subregions of adult rodent brain"Biomedical Res. 20・1. 43-49 (1999)
• [文献書誌] Narita M: "Consistent detection of CALM-AF10 chimeric transcripts in haematological malignancies with t(10;11)(p13;q14)and identification of novel transcripts"Brit J Haematol. 105・4. 928-937 (1999)
• [文献書誌] Yashige H: "Micronuclei and nuclear abnormalities observed in erythroblasts in myelodysplastic syndromes and in de novo acute leukemia after treatment"Acta Haematol(Basel). 101・1. 32-40 (1999)
• [文献書誌] Akagi T: "Cytogenetic analysis of the breakpoint at 18q21.1 in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue"Genes Chromosomes Cancer. 24・4. 315-321 (1999)
• [文献書誌] Iwai T: "Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia"Leukemia. 13・1. 38-43 (1999)
• [文献書誌] Tani S: "Chromosomal mapping of two PBP-J-related genes:Kyo-T and PBP-L"J Hum Genet. 44・1. 73-75 (1999)
• [文献書誌] Akagi T: "Cytogenetic analysis of the breakpoint at 18q21.1 in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue" Genes Chromosomes Cancer. (in press).
• [文献書誌] Iwai T: "Frequent aberration of FHIT gene expression in acute leukemia" Cancer Res. 56(22). 5182-5187 (1998)
• [文献書誌] Ohmori M: "A novel mature B-cell line (DOBIL-6) producing both parathoiroid hormone-related protein and interleukin-6 from a myeloma patient presenting with hypercalcaemia" Brit J Haematol. 101(4). 688-693 (1998)
• [文献書誌] Taki T: "ABI-1, a human homolog to a mouse Ab1-interactor 1, fuses the MLL gene in acute myeloid leukemia with t (10;11)(p11.2;q23)" Blood. 92(4). 1125-1130 (1998)
• [文献書誌] Tamura A: "Delincation of the breakpoint at 18q21.1 in a cell line (Karpas1106P) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multiple YAC clones" Int J Cancer. 78(1). 100-105 (1998)
• [文献書誌] Yabe D: "Human calumenin gene (CALU) : cDNA isolation and chromosomal mapping to 7q32" Genomics. 49(2). 331-333 (1998)