細胞周期制御

• 研究課題/領域番号: 12060101
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京大学
• 研究代表者: 岡山 博人 東京大学, 大学院医学系研究科, 教授 (40111950)
• 研究分担者: 岸本 健雄 東京工業大学, 大学院生命理工学研究科, 教授 (00124222) ; 鍔田 武志 東京医科歯科大学, 難治疾患研究所, 教授 (80197756) ; 西田 育巧 名古屋大学, 大学院理学研究科, 教授 (50107059) ; 大矢 禎一 東京大学, 大学院新領域創成科学研究科, 教授 (20183767) ; 東江 昭夫 東京大学, 大学院理学系研究科, 教授 (90029249)
• 研究期間 (年度): 2000 – 2005
• 研究課題ステータス: 完了 (2006年度)
• 配分額: 346,100千円 (直接経費: 346,100千円); 2006年度: 3,000千円 (直接経費: 3,000千円); 2005年度: 30,800千円 (直接経費: 30,800千円); 2004年度: 30,100千円 (直接経費: 30,100千円); 2003年度: 33,100千円 (直接経費: 33,100千円); 2002年度: 77,300千円 (直接経費: 77,300千円); 2001年度: 171,800千円 (直接経費: 171,800千円)
• キーワード: 細胞周期制御 / チェックポイント / S期開始制御 / 細胞死制御 / 細胞分化制御 / サイクリン依存性キナーゼ / ユビキチン依存性タンパク分解 / 細胞死と不死化 / 細胞周期と発生・分化 / G1 / G2 / 分化 / アポトーシス / 癌 / アポト-シス / 分裂酵母 / 姉妹染色分体結合 / NRK / 足場非依存性増殖 / Cdc6 / Cdk6

研究概要

当特定領域研究は、平成12年度に発足し、「細胞周期制御の分子機構を明らかにすることによって生命科学研究の最重要課題である増殖と分化の制御の分子メカニズムの解明を推進し、21世紀の医学・生物学の諸問題の解決のための知的基盤の形成に資すること」を目的とし研究を推進し、平成18年3月に終了した。
参加者は、計画班員延べ37名、公募班員延べ92名であった。
今年度は、その研究期間の成果の取りまとめを行った。
成果報告書は、1)領域の概要、2)研究領域における研究組織と各研究項目の連携状況、3)交付決定額、4)研究領域の設定目的及びその達成度、5)研究領域内の主な研究成果、6)研究成果の取りまとめ状況、7)班員の意見交換の場である全体進捗会議、8)当該研究分野及び関連研究分野への貢献度、9)研究成果公表状況、10)発表論文リスト、11)主な論文、12)参考資料I(毎年開催し国外から5-12名の招待講演及びほぼ同数の国内招待講演による国際ワークショップー覧)、13)参考資料II(研究課題一覧)からなり、1700頁を超える。
なお、研究成果に関しては、単なる論文発表された成果のみならず、未発表や現在も研究が進行中であるが、細胞周期制御機構の包括的解明のために極めて重要な突破口となりうる新知見をできるだけ記載するように努めた。また主な論文に関しては、トップクラスの国際誌掲載論文のみならず、先進性並びに波及効果の期待される成果の論文も載せるようにした。

研究成果

• [雑誌論文] Nonviral gene delivery by tetraamino fullerene. (2006)
  • 著者名/発表者名: Isobe, H., Nakanishi, W., Tomita, N., Jinno, S., Okayama, H., Nakamura, E.
  • 雑誌名: Mol. Pham. 3 ページ: 124-134
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • 著者名/発表者名: Nishiyama A, Muraki K, Saito M, Ohsumi K, Kishimoto T, Ishikawa F.
  • 雑誌名: EMBO J. 25 ページ: 575-584
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] p90Rsk is required for G1 phase arrest unfertilized starfish eggs. (2006)
  • 著者名/発表者名: Mori, M., Hara, M., Tachibana, K., Kishimoto, T.
  • 雑誌名: Development 133 ページ: 1823-1830
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identifying novel subustrates for mouse CDK5 using the yeast Saccharomyces cerevisiae. (2006)
  • 著者名/発表者名: Horiuchi, Y., Asada, A., Hisanaga, S., Toh-e, Nishizawa, M.
  • 雑誌名: Genes Cells 11 ページ: 1393-1404
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes. (2006)
  • 著者名/発表者名: Devi, S.S., Hagiyama, H., Adachi, T., Miyasaka, N., Tsubata, T.
  • 雑誌名: Signal Transduction 6 ページ: 54-61
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Bispecific antibodies against modified protein and DNA with oxidized lipids. (2006)
  • 著者名/発表者名: Akagawa M, Ito S, Toyoda K, Ishi Y, Tatsuda E, Shibata T, Kawai, Y., Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 103 ページ: 6160-6165
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila. (2006)
  • 著者名/発表者名: Yamasaki, Y., Nishida, Y.
  • 雑誌名: Develop. Growth Differ. 48 ページ: 411-418
  • NAID: 10020141408
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Evaluation of image processing programs for accurate measurement of budding and fission yeast morphology. (2006)
  • 著者名/発表者名: Suzuki, G., et al.
  • 雑誌名: Curr. Genet. 49 ページ: 237-247
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Nonviral gene delivery by tetraamino fullerene. (2006)
  • 著者名/発表者名: Isobe, H., Nakanishi, W., Tomita, N., Jinno, S., Okayama, H., Nakamura, E.
  • 雑誌名: Mol. Pharm. 3 ページ: 124-134
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • 著者名/発表者名: Nishiyama, A., Muraki, K., Saito, M., Ohsumi, K., Kishimoto, T., Ishikawa, F.
  • 雑誌名: EMBO J. 25 ページ: 575-584
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] p90Rsk is required for Gl phase arrest in unfertilized starfish eggs. (2006)
  • 著者名/発表者名: Mori, M., Hara, M., Tachibana, K., Kishimoto, T.
  • 雑誌名: Development 133 ページ: 1823-1830
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identifying novel substrates for mouse CDK5 using the yeast Saccharomyces cerevisiae. (2006)
  • 著者名/発表者名: Horiuchi, Y., Asada, A., Hisanaga, S., Toh-e, A., Nishizawa, M.
  • 雑誌名: Genes Cells 11 ページ: 1393-1404
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Bispecific antibodies against modified protein and DNA with oxidized lipids. (2006)
  • 著者名/発表者名: Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Kawai, Y., Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 103 ページ: 6160-6165
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Evaluation of image processing programs for accurate measurement of budding and fission yeast morphology. (2006)
  • 著者名/発表者名: Suzuki, G. et al.
  • 雑誌名: Curr Genet. 49 ページ: 237-247
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes. (2006)
  • 著者名/発表者名: Devi, S.S., Hagiyama, H., Adachi, T., Miyasaka, N., Tsubata, T.
  • 雑誌名: Signal Transduction (印刷中)
• [雑誌論文] Bispecific antibodies against modified protein and DNA with oxidized lipids. (2006)
  • 著者名/発表者名: Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T., Uchida, K.
  • 雑誌名: Proc.Natl.Acad.Sci.USA (印刷中)
• [雑誌論文] Gene delivery by aminofullerene : structural requirements for efficient transfection. (2006)
  • 著者名/発表者名: Isobe, H., Nakanishi, W., Tomita, N., Jinno S., Okayama, H., Nakamura, E.
  • 雑誌名: Chemistry-An Asian J. (印刷中)
• [雑誌論文] Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. (2005)
  • 著者名/発表者名: Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H.
  • 雑誌名: J. Cell Physiol. 204 ページ: 927-933
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs. (2005)
  • 著者名/発表者名: Yamamoto, T.M., Iwabuchi, M., Ohsumi, K., Kishimoto, T.
  • 雑誌名: Dev. Biol. 279 ページ: 345-355
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Nucleosome assembly protein-1 is a linker histone chaperone in Xenopus eggs. (2005)
  • 著者名/発表者名: Shintomi K, Iwabuchi M, Saeki H, Ura K, Kishimoto T, Ohsumi, K.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 102 ページ: 8210-8215
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] In memory of Andre Picard : 1950-2004(Obituary). (2005)
  • 著者名/発表者名: Kishimoto, T.
  • 雑誌名: Biol. Cell 97 ページ: 349-350
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cell cycle unleashed (News and Views). (2005)
  • 著者名/発表者名: Kishimoto, T.
  • 雑誌名: Nature 437 ページ: 963-965
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Functional analysis of Rpn6p, a lid component of the 26 S proteasome, using temperature-sensitive rpn6 mutants of the yeast Saccharomyces cerevisiae. (2005)
  • 著者名/発表者名: Isono, E., Saito, N., Kamata, N., Saeki, Y., Toh-e, A.
  • 雑誌名: J Biol Chem. 280 ページ: 6537-6547
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] In vivo time-resolved Raman imaging of a spontaneous death process of a single budding yeast cell. (2005)
  • 著者名/発表者名: Yasuaki Nito, Akio Tho-e, Hiro-o Hamaguchi
  • 雑誌名: J Raman Spectroscopy 36 ページ: 837-839
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] LAS24/KOG1, a component of the TOR complex 1 (TORC1) is needed for resistance to local anesthetic and normal distribution of actin cytoskeleton in yeast. (2005)
  • 著者名/発表者名: Tomoyuki Araki, Yukifumi Uesono, Tomoko Oguchi, Akiko Toh-e
  • 雑誌名: Genes Genet Syst. 80 ページ: 325-343
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Preparation of ubiquitinated substrates by the PY motif-insertion method for monitoring 26S proteasome activity. (2005)
  • 著者名/発表者名: Saeki, Y., Isonom, E., Toh-e, A.
  • 雑誌名: Method. Enzymol. 399 ページ: 215-227
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Knocking out ubiquitin proteasome system function in vivo and in vitro with genetically encodable tandem ubiquitin. (2005)
  • 著者名/発表者名: Saeki, Y., Isonom, E., Shimada, M., Kawahara, H., Yokosawa, H., Toh-e, A.
  • 雑誌名: Method. Enzymol. 399 ページ: 64-74
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] B cell abnormality and autoimmune disorders. (2005)
  • 著者名/発表者名: Tsubata, T.
  • 雑誌名: Autoimmunity 38 ページ: 331-337
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] High-dimensional and large-scale phenotyping of yeast mutants. (2005)
  • 著者名/発表者名: Ohya, Y., et al.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 102 ページ: 19015-19020
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase. (2005)
  • 著者名/発表者名: Kondoh, O., et al.
  • 雑誌名: Biol Pharm Bull. 28 ページ: 2138-2141
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Data Mining Tools for Saccharomyces Cerevisiae Morphological Database. (2005)
  • 著者名/発表者名: Saito, T., et al.
  • 雑誌名: Nuc. Acid Res. 33
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular dissection of ARP1 regions required for nuclear migration and cell wall integrity checkpoint functions in Saccharomyces cerevisiae. (2005)
  • 著者名/発表者名: Igarashi, R., et al.
  • 雑誌名: Cell Struct Funct. 30 ページ: 57-67
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Involvement of actin and polarisome in morphological change during spore germination of Saccharomyces cerevisiae. (2005)
  • 著者名/発表者名: Kono, K., et al.
  • 雑誌名: Yeast 22 ページ: 129-139
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs : Implications for the molecular pathogenesis of human mitochondrial diseases. (2005)
  • 著者名/発表者名: Umeda, N., et al.
  • 雑誌名: J Biol Chem. 280 ページ: 1613-1624
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Nucleosome assembly protein-1 is a linker histone chaperone in Xenopus eggs. (2005)
  • 著者名/発表者名: Shintomi, K., Iwabuchi, M., Saeki, H., Ura, K., Kishimoto, T., Ohsumi, K.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 102 ページ: 8210-8215
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] In memory of Andre Picard : 1950-2004 (Obituary). (2005)
  • 著者名/発表者名: Kishimoto, T.
  • 雑誌名: Biol. Cell 97 ページ: 349-350
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] In vivo time-resolved Raman imaging of a spontaneous death process of a single budding yeast cell. (2005)
  • 著者名/発表者名: Yasuaki Naito, Akio Toh-e, Hiro-o Hamaguchi
  • 雑誌名: J Raman Spectroscopy 36 ページ: 837-839
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] LAS24/KOG1, a component of the TOR complex 1 (TORC1) is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. (2005)
  • 著者名/発表者名: Tomoyuki Araki, Yukifumi Uesono, Tomoko Oguchi, Akio Toh-e
  • 雑誌名: Genes Genet Syst. 80 ページ: 325-343
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Preparation of ubiquitinated substrates by the PY motif-insertion method for monitoring 26S proteasome activity. (2005)
  • 著者名/発表者名: Saeki, Y., Isono, E., Toh-e, A.
  • 雑誌名: Method. Enzymol. 399 ページ: 215-227
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Knocking out ubiquitin proteasome system function in vivo and in vitro with genetically encodable tandem ubiquitin. (2005)
  • 著者名/発表者名: Saeki, Y., Isono, E., Shimada, M., Kawahara, H., Yokosawa, H., Toh-e, A.
  • 雑誌名: Method. Enzymol. 399 ページ: 64-74
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] High-dimensional and large-scale phenotyping of yeast mutants. (2005)
  • 著者名/発表者名: Ohya, Y. et al.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 102 ページ: 19015-19020
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase. (2005)
  • 著者名/発表者名: Kondoh, O. et al.
  • 雑誌名: Biol Pharm Bull. 28 ページ: 2138-2141
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Data Mining Tools for Saccharomyces Cerevisiae Morphological Database. (2005)
  • 著者名/発表者名: Saito, T. et al.
  • 雑誌名: Nuc.Acid Res. 33
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Molecular dissection of ARP1 regions required for nuclear migration and cell wall integrity checkpoint functions in Saccharomyces cerevisiae. (2005)
  • 著者名/発表者名: Igarashi, R. et al.
  • 雑誌名: Cell Struct Funct. 30 ページ: 57-67
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Involvement of actin and polarisome in morphological change during spore germination of Saccharomyces cerevisiae. (2005)
  • 著者名/発表者名: Kono, K. et al.
  • 雑誌名: Yeast 22 ページ: 129-139
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs: Implications for the molecular pathogenesis of human mitochondrial diseases. (2005)
  • 著者名/発表者名: Umeda, N. et al.
  • 雑誌名: J Biol Chem. 280 ページ: 1613-1624
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. (2005)
  • 著者名/発表者名: Moro, T., Ogasawara, T., Chikuda, H., Ikeda, T., Ogata, N., Maruyama, Z., Komori, T., Hoshi, K., Chung, U.I., Nakamura, K., Okayama.H., Kawaguchi H.
  • 雑誌名: J.Cell Physiol. 204 ページ: 927-933
• [雑誌論文] APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs. (2005)
  • 著者名/発表者名: Yamamoto, T.M., Iwabuchi, M., Ohsumi, K., Kishimoto, T.
  • 雑誌名: Dev.Biol. 279 ページ: 345-355
• [雑誌論文] Nucleosome assembly protein-1 is a linker histone chaperone in Xenopus eggs. (2005)
  • 著者名/発表者名: Shintomi, K., Iwabuchi, M., Saeki, H., Ura, K., Kishimoto, T., Ohsumi, K.
  • 雑誌名: Proc.Natl.Acad.Sci.USA 102 ページ: 8210-8215
• [雑誌論文] in vivo time-resolved Raman imaging of a spontaneous death process of a single budding yeast cell. (2005)
  • 著者名/発表者名: Yasuaki Naito, Akio Toh-e, Hiro-o Hamaguchi
  • 雑誌名: J Raman Spectroscopy 36 ページ: 837-839
• [雑誌論文] LAS24/KOG1, a component of the TOR complex 1 (TORC1) is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. (2005)
  • 著者名/発表者名: Tomoyuki Araki, Yukifumi Uesono, Tomoko Oguchi, Akio Toh-e
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• [雑誌論文] Bone morphogenetic protein-2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. (2004)
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• [雑誌論文] PDK1 is required for the hormonal signalling pathway leading to meiotic resumption in starfish oocytes. (2004)
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  • 雑誌名: Mol. Biol. Cell 15 ページ: 1544-1556
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• [雑誌論文] Ybr267W is new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae. (2004)
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• [雑誌論文] Dynactin complex is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae. (2004)
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• [雑誌論文] Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6). (2004)
  • 著者名/発表者名: Ogasawara, T., Katagiri, M., Yamamoto, A., Hoshi, K., Takato, T., Nakamura, K., Tanaka, S., Okayama, H., Kawaguchi, H.
  • 雑誌名: J. Bone Miner. Res. 19 ページ: 1128-1136
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] More than Gl or G2 arrest : Useful starfish oocyte system for investigating skillful MAP kinase. (2004)
  • 著者名/発表者名: Kishimoto, T.
  • 雑誌名: Biol. Cell 96 ページ: 241-244
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Simultaneous yet independent regulation of actin cytoskeleton organization and translation initiation by glucose in Saccharomyces cerevisiae. (2004)
  • 著者名/発表者名: Uesono, Y., Ashe, P., Toh-e, A.
  • 雑誌名: Mol. Biol. Cell 15 ページ: 1544-1556
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Yeast Pho85 kinase is required for proper gene expression during the diauxic shift. (2004)
  • 著者名/発表者名: Nishizawa, M., Katou, H., Shirahige, K., Toh-e, A.
  • 雑誌名: Yeast 21 ページ: 903-918
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Rpn7 is required for the structural integrity of the 26S proteasome of Saccharomyces cerevisiae. (2004)
  • 著者名/発表者名: Isono, E., et al.
  • 雑誌名: J. Biol. Chem. 279 ページ: 27168-27176
  • 説明: 「研究成果報告書概要(欧文)」より
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  • 著者名/発表者名: Sone, T., et al.
  • 雑誌名: J. Biol. Chem. 279 ページ: 28807-28816
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Intracellularly inducible, ubiquitin hydrolase-insensitive tandem ubiquitins inhibit the 26S proteasome activity and cell division. (2004)
  • 著者名/発表者名: Saeki, Y., et al.
  • 雑誌名: Genes Genet. Syst. 79 ページ: 77-86
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Definitive evidence for Ufd2-catalyzed elongation of the ubiquitin chain through Lys48 linkage. (2004)
  • 著者名/発表者名: Saeki, Y., et al.
  • 雑誌名: Biochem. Biophys. Res. Commun. 320 ページ: 840-845
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mmrlp is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. (2004)
  • 著者名/発表者名: Itoh, T., Toh-e, A., Matsui, Y.
  • 雑誌名: EMBO J. 23 ページ: 2520-2530
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Ectopic CD40 ligand expression on B cells trigger intestinal inflammation. (2004)
  • 著者名/発表者名: Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M.
  • 雑誌名: J. Immunol. 172 ページ: 6388-6397
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• [雑誌論文] Dynactin complex is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae. (2004)
  • 著者名/発表者名: Suzuki, M. et al.
  • 雑誌名: Nat. Cell Biol. 6 ページ: 861-871
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Cell shape and growth of budding yeast cells in restrictive microenvironments. (2004)
  • 著者名/発表者名: Suzuki, M. et al.
  • 雑誌名: Yeast 21 ページ: 983-989
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Molecular mechanism of vde-initiated intein homing in yeast nuclear genome. (2004)
  • 著者名/発表者名: Fukuda T, et al.
  • 雑誌名: Adv Biophys. 38 ページ: 215-232
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] SCMD:Saccaromyces cerevisiae morphological database. (2004)
  • 著者名/発表者名: Saito, T.L.et al.
  • 雑誌名: Nuc. Acid Res. 32
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Analysis of the molecular interaction of the farnesyl moiety of transducin through use of a photoreactive farnesyl analog. (2004)
  • 著者名/発表者名: Hagiwara, K. et al.
  • 雑誌名: Biochemstry 43 ページ: 300-309
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Development of Image Processing Program for Yeast Cell Morphology. (2004)
  • 著者名/発表者名: Ohtani, M. et al.
  • 雑誌名: J. Bioinfo. Comput. Biol. 1 ページ: 695-709
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Bone morphogenetic protein-2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6 (2004)
  • 著者名/発表者名: Ogasawara, T., Kawaguchi, H., Jinno, S., Hoshi, K., Itaka, K., Takato, T., Nakamura, K., Okayama, H.
  • 雑誌名: Mol.Cell.Biol. 24 ページ: 6560-6568
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  • 雑誌名: Proc.Natl.Acad.Sci.USA 101 ページ: 12531-12536
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  • 雑誌名: Cell Death Differ. 11 ページ: 261-269
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• [雑誌論文] Rpf2p, and evolutionally conserved protein, interacts with ribosomal protein L11 and is essential for processing of 27SB pre-rRNA to 25S rRNA and 60S ribosomal subunit assembly in Saccharomyces cerevisiae. (2002)
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• [雑誌論文] Budding yeast Cdc5 phosphorylates Netl and assists Cdc14 release from the nucleolus. (2002)
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• [雑誌論文] Identification of ubiquitin-like proteins binding subunits of the 26S proteasome. (2002)
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• [雑誌論文] Complex formation with the class V myosin is essential for Yptllp, a rab type small GTPase, to facilitate the Myo2p function for mitochondrial distribution in the budding yeast. (2002)
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• [雑誌論文] The small GTPase Rho3 and diaphanous/forming For3 function in polarized cell growth in fission yeast. (2002)
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  • 雑誌名: J. Biol. Chem. 276 ページ: 26648-26655
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular mechanisms for apoptosis induced by signaling through the B cell antigen receptor. (2001)
  • 著者名/発表者名: Tsubata, T.
  • 雑誌名: Int. Rev. Immunol. 20 ページ: 791-803
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A Drosophila MAPKKK, DMEKK1, mediates stress responses through activation of p38 MAPK. (2001)
  • 著者名/発表者名: Inoue, H. et al.
  • 雑誌名: EMBO J. 20 ページ: 5421-5430
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] E2F-dependent transcription of the raf proto-oncogene During Drosophila development. (2001)
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  • 雑誌名: Nucleic Acid. Res. 29 ページ: 1808-1814
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. (2001)
  • 著者名/発表者名: Lin, J., Jinno, S., Okayama, H.
  • 雑誌名: Oncogene 20 ページ: 2000-2009
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism. (2001)
  • 著者名/発表者名: Tanaka, K., Hao, Z., Kai, M., Okayama, H.
  • 雑誌名: EMBOJ. 20 ページ: 5779-5790
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Inactivation of the checkpoint kinase Cdsl is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M-phase transition in Xenopus oocytes. (2001)
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  • 雑誌名: J. Cell Sci. 114 ページ: 3397-3406
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A novel functional domain of Cdc15 kinase is required for its interaction with Teml GTPase in Saccharomyces cerevisiae. (2001)
  • 著者名/発表者名: Asakawa, K., Yoshida, S., Otake, F., Toh-e, A.
  • 雑誌名: Genetics 157 ページ: 1437-1450
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Spindle Checkpoint Control in Budding Yeast. (2001)
  • 著者名/発表者名: Toh-e, A., Asakawa, K., Yoshida, S.
  • 雑誌名: J. Microbiol. 39 ページ: 1-10
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Regulation of the localization of Dbf2 and Mobl during cell division of Saccharomyces cerevisiae. (2001)
  • 著者名/発表者名: Yoshida, S., Toh-e, A.
  • 雑誌名: Gene Genet Syst. 76 ページ: 141-147
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. (2001)
  • 著者名/発表者名: Takahashi, Y., Toh-e, A., Kikuchi, Y.
  • 雑誌名: Gene 275 ページ: 223-231
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Yeast U111/Sizl is a novel SUMO-1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. (2001)
  • 著者名/発表者名: Takahashi, Y., Kahyo, T., Toh-e, A., Yasuda, H., Kikuchi, Y.
  • 雑誌名: J. Biol. Chem. 276 ページ: 48973-48977
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Structure and function of cyclin-dependent Pho85 kinase of Saccharomyces cerevisiae. (2001)
  • 著者名/発表者名: Toh-e, A., Nishizawa, M.
  • 雑誌名: J. Gen. Appl. Microbiol. 47 ページ: 107-117
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Nisi encoded by YNL078W : a new neck protein of Saccharomyces cerevisiae. (2001)
  • 著者名/発表者名: Iwase, M., Toh-e, A.
  • 雑誌名: Gene. Genet. Syst. 76 ページ: 335-343
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Defects in glycosylphosphatidylinositol(GPI) anchor synthesis activate Hogl kinase and confer copper-resistance on Saccharomyces cerevisiae. (2001)
  • 著者名/発表者名: Toh-e, A., Oguchi, T.
  • 雑誌名: Gene. Genet. Syst. 76 ページ: 393-410
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. (2001)
  • 著者名/発表者名: Adachi, T., Wienands, J., Wakabayashi, C, Yakura, H., Reth, M., Tsubata, T.
  • 雑誌名: J. Biol. Chem. 276 ページ: 26648-26655
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The polyubiquitin gene is essential for meiosis fission yeast. (2000)
  • 著者名/発表者名: Okazaki K, Okayama H, Niwa O.
  • 雑誌名: Exp Cell Res. 254 ページ: 143-152
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling. (2000)
  • 著者名/発表者名: Kizaka-Kondoh S, Akiyama N, Okayama H.
  • 雑誌名: FEBS Lett. 466 ページ: 160-164
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• [雑誌論文] Genetic Studies with the Fission Yeast Schizosaccharomyces pombe Suggest Involvement of Wee1, Ppa2, and Rad24 in Induction of Cell Cycle Arrest by Human Immunodeficiency Virus Type 1 Vpr. (2000)
  • 著者名/発表者名: Masuda M, Nagai Y, Oshima N, Tanaka K, Murakami H, Igarashi H, Okayama H.
  • 雑誌名: J Virol. 74 ページ: 2636-2646
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Fission Yeast Esolp Is Required for Establishing Sister Chromatid Cohesion during S Phase. (2000)
  • 著者名/発表者名: Tanaka, K., Yonekawa, T., Kawasaki, Y., Kai, M., Furuya, K., Iwasaki, M., Murakami, H., Yanagida, M., Okayama, H.
  • 雑誌名: Molecular And Cellular Biology 20 ページ: 3459-3469
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A Pcl-like Cyclin Activates the Res2p-Cdc10p Cell Cycle "Start" Transcriptional Factor Complex in Fission Yeast. (2000)
  • 著者名/発表者名: Tanaka, K., Okayama, H.
  • 雑誌名: Molecular Biology of the Cell 11 ページ: 2845-2862
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Loop-mediated isothermal amplification of DNA. (2000)
  • 著者名/発表者名: Notomi T, Okayama H, Masubuchi H, Yonekawa T, Watanabe K, Amino N, Hase T.
  • 雑誌名: Nucleic Acids Res. 28
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• [雑誌論文] Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. (2000)
  • 著者名/発表者名: Nakanishi, M., Ando, H., Watanabe, N., Kitamura, K., Ito, K., Okayama, H., Miyamoto, T., Agui, T., Sasaki, M.
  • 雑誌名: Genes to Cells. 5 ページ: 839-847
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Fission Yeast Fizzy-related protein srw1p is a G_1-specific promoter of mitotic cyclin B degradation. (2000)
  • 著者名/発表者名: Yamaguchi, S., Okayama, H., Nurse, P.
  • 雑誌名: The EMBO Journal 19 ページ: 3968-3977
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• [雑誌論文] Functionalized Fullerene as an Artificial Vector for Transfection. (2000)
  • 著者名/発表者名: Nakamura, E., Isobe, H., Tomita, N., Sawamura, M., Jinno, S., Okayama, H.
  • 雑誌名: Angew. Chem. Int. Ed. 39 ページ: 4254-4257
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts. (2000)
  • 著者名/発表者名: Iwabuchi M, Ohsumi K, Yamamoto TM, Sawada W, Kishimoto T.
  • 雑誌名: EMBO J. 19 ページ: 4513-4523
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A non-proteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M-phase. (2000)
  • 著者名/発表者名: Nisiyama, A., Tachibana, K., Igarashi, Y, Yasuda, H., Tanahashi, N., Tanaka, K., Ohsumi, K., Kishimoto, T.
  • 雑誌名: Genes Dev. 14 ページ: 2344-2357
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes. (2000)
  • 著者名/発表者名: Tachibana, K., Tanaka, D., Isobe, T., Kishimoto, T.
  • 雑誌名: Proc. Natl. Acad. Sci. U.S.A. 97 ページ: 14301-14306
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. (2000)
  • 著者名/発表者名: Kitazawa H, Iida J, Uchida A, Haino-Fukushima K, Itoh TJ, Hotani H, Ookata K, Murofushi H, Bulinski JC, Kishimoto T, Hisanaga S.
  • 雑誌名: Cell Struc. Funct. 25 ページ: 33-39
  • NAID: 10006678784
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary culture of embryo rat cortical neurons. (2000)
  • 著者名/発表者名: Tokuoka H, Saito T, Yorifuji H, Wei F-Y, Kishimoto T, Hisanaga S.
  • 雑誌名: J. Cell Sci. 113 ページ: 1059-1068
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. (2000)
  • 著者名/発表者名: Kusakawa G, Saito T, Onuki R, Ishiguro K, Kishimoto T, Hisanaga S.
  • 雑誌名: J. Biol. Chem. 275 ページ: 17166-17172
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. (2000)
  • 著者名/発表者名: Kawahara H, Kasahara M, Nishiyama A, Ohsumi K, Goto T, Kishimoto T, Saeki Y, Yokosawa H, Shimbara N, Murata S, Chiba T, Suzuki K, Tanaka T.
  • 雑誌名: EMBO J. 19 ページ: 4144-4153
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Regulation of JNK by Src during Drosophila development. (2000)
  • 著者名/発表者名: Tateno, M., Nishida, Y., Adachi-Yamada, T.
  • 雑誌名: Science 287 ページ: 324-327
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development. (2000)
  • 著者名/発表者名: Sugimura, I., Adachi-Yamada, T., Nishi, Y., Nishida, Y.
  • 雑誌名: Develp. Growth Differ. 42 ページ: 237-248
  • NAID: 10016988399
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Transcriptional regulation of the Drosophila raf proto-oncogene by Drosophila STAT during development and in immune response. (2000)
  • 著者名/発表者名: Kwon E-J, Park H-S, Kim Y-S, Oh E-J, Nishida Y, Matsukage A, Yoo M-A, Yamaguchi M.
  • 雑誌名: J. Biol. Chem. 275 ページ: 19824-19830
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Characterization of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF). (2000)
  • 著者名/発表者名: Ohno K, Takahashi Y, Hirose F, Inoue YH, Taguchi O, Nishida Y, Matsukage A, Yamaguchi M.
  • 雑誌名: Gene 260 ページ: 133-143
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The polyubiquitin gene is essential for meiosis in fission yeast. (2000)
  • 著者名/発表者名: Okazaki K, Okayama H, Niwa O.
  • 雑誌名: Exp Cell Res. 254 ページ: 143-152
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Genetic Studies with the Fission Yeast Schizosaccharomyces pombe Suggest Involvement of Weel, Ppa2, and Rad24 in Induction of Cell Cycle Arrest by Human Immunodeficiency Virus Type 1 Vpr. (2000)
  • 著者名/発表者名: Masuda M, Nagai Y, Oshima N, Tanaka K, Murakami H, Igarashi H, Okayama H.
  • 雑誌名: J Virol. 74 ページ: 2636-2646
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A Pcl-like Cyclin Activates the Res2p-CdclOp Cell Cycle "Start" Transcriptional Factor Complex in Fission Yeast. (2000)
  • 著者名/発表者名: Tanaka, K., Okayama, H.
  • 雑誌名: Molecular Biology of the Cell 11 ページ: 2845-2862
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification and characterization of human Wee1B, a new member of the Weel family of Cdk-inhibitory kinases. (2000)
  • 著者名/発表者名: Nakanishi, M., Ando, H., Watanabe, N., Kitamura, K., Ito, K., Okayama, H., Miyamoto, T., Agui, T., Sasaki, M.
  • 雑誌名: Genes to Cells. 5 ページ: 839-847
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Fission Yeast Fizzy-related protein srwlp is a Gl-specific promoter of mitotic cyclin B degradation. (2000)
  • 著者名/発表者名: Yamaguchi, S., Okayama, H., Nurse, P.
  • 雑誌名: The EMBO Journal 19 ページ: 3968-3977
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts. (2000)
  • 著者名/発表者名: Iwabuchi, M., Ohsumi, K., Yamamoto, T.M., Sawada, W., Kishimoto, T.
  • 雑誌名: EMBOJ. 19 ページ: 4513-4523
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A non-proteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M-phase. (2000)
  • 著者名/発表者名: Nishiyama, A., Tachibana, K., Igarashi, Y., Yasuda, H., Tanahashi, N., Tanaka, K., Ohsumi, K., Kishimoto, T.
  • 雑誌名: Genes Dev. 14 ページ: 2344-2357
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. (2000)
  • 著者名/発表者名: Kitazawa H, Iida J, Uchida A, Haino-Fukushima K, Itoh TJ, Hotani H, Ookata K, Murofushi H, Bulinski J.C., Kishimoto T, Hisanaga S.
  • 雑誌名: Cell Struc. Funct. 25 ページ: 33-39
  • NAID: 10006678784
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary culture of embryo rat cortical neurons. (2000)
  • 著者名/発表者名: Tokuoka, H., Saito, T., Yorifuji, H., Wei, F-Y., Kishimoto, T., Hisanaga, S.
  • 雑誌名: J. Cell Sci. 113 ページ: 1059-1068
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. (2000)
  • 著者名/発表者名: Kusakawa, G., Saito, T., Onuki, R., Ishiguro, K., Kishimoto, T., Hisanaga, S.
  • 雑誌名: J. Biol. Chem. 275 ページ: 17166-17172
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. (2000)
  • 著者名/発表者名: Kawahara, H., Kasahara, M., Nishiyama, A., Ohsumi, K., Goto, T., Kishimoto, T., Saeki, Y., Yokosawa, H., Shimbara, N., Murata, S., Chiba, T., Suzuki, K., Tanaka, T.
  • 雑誌名: EMBO J. 19 ページ: 4144-4153
  • 説明: 「研究成果報告書概要(欧文)」より
• [図書] 細胞周期集中マスター(北川雅敏編) (2006)
  • 著者名/発表者名: 岸本健雄(分担)
  • 総ページ数: 154
  • 出版者: 羊土社
  • 説明: 「研究成果報告書概要(和文)」より
• [図書] 発生における細胞増殖制御 (2004)
  • 著者名/発表者名: 竹内隆, 岸本健雄(編集)
  • 総ページ数: 198
  • 出版者: シュプリンガーフェアラーク東京
  • 説明: 「研究成果報告書概要(和文)」より
• [図書] 日本生化学会・バイオサイエンスの新世紀 第6巻 「細胞の誕生と死」(長田重一, 山本雅編) (2001)
  • 著者名/発表者名: 岸本健雄(分担)
  • 総ページ数: 198
  • 出版者: 共立出版
  • 説明: 「研究成果報告書概要(和文)」より
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