循環器疾患関連遺伝子群の解明

• 研究課題/領域番号: 12204004
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京医科歯科大学
• 研究代表者: 木村 彰方 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
• 研究分担者: 和泉 徹 北里大学, 医学部, 教授 (80143775) ; 安波 道郎 東京医科歯科大学, 大学院疾患生命科学研究部, 助教授 (80244127) ; 赤井 潤 東京医科歯科大学, 難治疾患研究所, 助手 (70302891) ; 吉田 雅幸 東京医科歯科大学, 難治疾患研究所, 助教授 (80282771)
• 研究期間 (年度): 2000 – 2004
• 研究課題ステータス: 完了 (2004年度)
• 配分額: 59,900千円 (直接経費: 59,900千円); 2004年度: 16,000千円 (直接経費: 16,000千円); 2003年度: 16,000千円 (直接経費: 16,000千円); 2002年度: 14,400千円 (直接経費: 14,400千円); 2001年度: 13,500千円 (直接経費: 13,500千円)
• キーワード: 遺伝子変異 / 高血圧性心筋症 / 不整脈 / 心不全 / 心筋梗塞 / マイクロサテライト / 難治性動脈炎 / 特発性心筋症 / ゲノム多様性 / LTA / 高血圧 / 心筋症 / 高安病 / 動物モデル / HLA / 心肥大 / 循環器疾患 / 機能解析 / DSSラット

研究概要

1)候補遺伝子アプローチによって、SELE, PECAM1,CD14多型と日本人心筋梗塞の関連を発見し、SEE多型は白血球と血管内皮の接着効率に関わることを証明した。また、500-600名の患者-コントロール比較を行ったが、LTA、LGALS2、p22phoxと心筋梗塞との関連は認められなかった。一方、常染色体上の18,800のマイクロサテライトについて、患者-コントロール集団のプール解析と個別タイピングを実施し、5座位について心筋梗塞との有意か関連を発見した。これらはいずれも既知の心筋梗塞関連遺伝子座とは異なっていた。
2)食塩感受性高血圧ラット心筋で発現変化する遺伝子群のヒトオルソローグを解析し,高血圧性心筋症に有意に関連するBMP10遺伝子変異を同定した。また,BMP10はTcapに結合すること,疾患関連変異はその結合性を減弱することを解明した。一方、BMP10と類似した発現変化パターンを示すTTN、MLP、サイファー、TCAP、FHL2遺伝子のそれぞれについて、その変異が拡張型心筋症の原因となること、およびそれぞれの機能変化を明らかにした。また、肥大型心筋症の原因となるCAV3変異およびTCAP変異を発見し、それらの機能変化を解明した。これとは別に、種々の不整脈患者についてチャネル遺伝子群の体系的な変異ないし多型の検索を行った結果、患者集団に特徴的なHCN4、KCNQ1、KCMH2、SCN5AあるいはRYR2遺伝子変異を発見し、それぞれの機能変化を解明した。
3)高安動脈炎、バージャー病のそれぞれについて、HLA領域内のマイクロサテライトおよびSNP解析を行い、高安動脈炎感受性遺伝子としてHLA-BおよびIKBL、バージャー病感受性遺伝子としてHLA-DRB1およびHLA-DPB1遺伝子を同定した。さらに、HLA-E近傍にもうひとつのバージャー病感受性遺伝子があることを明らかにした。

研究成果

• [雑誌論文] Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan (2005)
  • 著者名/発表者名: Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T
  • 雑誌名: Eur Resp J 25 ページ: 131-138
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan. (2005)
  • 著者名/発表者名: Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, T atsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T
  • 雑誌名: Eur Resp J 25 ページ: 131-138
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan (2005)
  • 著者名/発表者名: Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T
  • 雑誌名: Eur.Resp.J. 25 ページ: 131-138
• [雑誌論文] Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy (2005)
  • 著者名/発表者名: Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, Arimura T, Nakamura K, Ashizawa N, Yasunami M, Ohe T, Yano A, Kimura A
  • 雑誌名: J.Muscle Res.Cell Motil (In press)
• [雑誌論文] Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy (2004)
  • 著者名/発表者名: Hayashi T, Arimura T, Ueda, K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A
  • 雑誌名: Biochem Biophys Res Commun 313 ページ: 178-184
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C (2004)
  • 著者名/発表者名: Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A
  • 雑誌名: J Biol Chem 279 ページ: 6746-6752
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene (2004)
  • 著者名/発表者名: Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K
  • 雑誌名: Circ J 68 ページ: 174-177
  • NAID: 110002667503
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese (2004)
  • 著者名/発表者名: Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H
  • 雑誌名: Tissue Antigens 63 ページ: 223-230
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The role of a common TNNT2 polymorphism in cardiac hypertrophy (2004)
  • 著者名/発表者名: Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K
  • 雑誌名: J Hum Genet 49 ページ: 129-133
  • NAID: 10012891095
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia (2004)
  • 著者名/発表者名: Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
  • 雑誌名: J Biol Chem 279 ページ: 27194-27198
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Unexpected mexiletine responses of a mutant cardiac Na^+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access (2004)
  • 著者名/発表者名: Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A
  • 雑誌名: Mol Pharmacol 66 ページ: 330-336
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking (2004)
  • 著者名/発表者名: Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M
  • 雑誌名: FEBS Lett 574 ページ: 145-150
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation (2004)
  • 著者名/発表者名: Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M
  • 雑誌名: J Mol Cell Cardiol 37 ページ: 1205-1211
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy (2004)
  • 著者名/発表者名: Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki, N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A
  • 雑誌名: J Am. Col Cardiol 44 ページ: 2192-2201
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy. (2004)
  • 著者名/発表者名: Hayashi T, Arimura T, Ueda, K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A
  • 雑誌名: Biochem Biophys Res Commun 313 ページ: 178-184
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. (2004)
  • 著者名/発表者名: Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A
  • 雑誌名: J Biol Chem 279 ページ: 6746-6752
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene. (2004)
  • 著者名/発表者名: Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K
  • 雑誌名: Circ J 68 ページ: 174-177
  • NAID: 110002667503
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese. (2004)
  • 著者名/発表者名: Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H
  • 雑誌名: Tissue Antigens 63 ページ: 223-230
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The role of a common TNNT2 polymorphism in cardiac hypertrophy. (2004)
  • 著者名/発表者名: Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K
  • 雑誌名: J Hum Genet 49 ページ: 129-133
  • NAID: 10012891095
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. (2004)
  • 著者名/発表者名: Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, YasunamiM, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
  • 雑誌名: J Biol Chem 279 ページ: 27194-27198
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes. (2004)
  • 著者名/発表者名: Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H
  • 雑誌名: Diabet. Res. Clin. Pract. 66 ページ: 163-171
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access. (2004)
  • 著者名/発表者名: Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A
  • 雑誌名: Mol Pharmacol 66 ページ: 330-336
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Truncated KCNQ1 mutant, A178fs/105,forms hetero-multimer channel with wild-type causing adominant-negative suppression due to trafficking. (2004)
  • 著者名/発表者名: Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M
  • 雑誌名: FEBS Lett 574 ページ: 145-150
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation. (2004)
  • 著者名/発表者名: Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, YasunamiM Isobe M, Kimura A, Hiraoka M
  • 雑誌名: J Mol Cell Cardiol 37 ページ: 1205-1211
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. (2004)
  • 著者名/発表者名: Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki, N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A
  • 雑誌名: J Am. Col Cardiol 44 ページ: 2192-2201
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C (2004)
  • 著者名/発表者名: Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A
  • 雑誌名: J.Biol.Chem. 279 ページ: 6746-6752
• [雑誌論文] TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy (2004)
  • 著者名/発表者名: Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A.
  • 雑誌名: J.Am.Col.Cardiol 44 ページ: 2192-2201
• [雑誌論文] The role of a common TNNT2 polymorphism in cardiac hypertrophy (2004)
  • 著者名/発表者名: Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K
  • 雑誌名: J.Hum.Genet 49 ページ: 129-133
  • NAID: 10012891095
• [雑誌論文] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia (2004)
  • 著者名/発表者名: Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
  • 雑誌名: J.Biol.Chem. 279 ページ: 27194-27198
• [雑誌論文] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking. (2004)
  • 著者名/発表者名: Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M
  • 雑誌名: FEBS Lett 574 ページ: 145-150
• [雑誌論文] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation (2004)
  • 著者名/発表者名: Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M
  • 雑誌名: J.Mol.Cell.Cardiol. 37 ページ: 1205-1211
• [雑誌論文] Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes (2004)
  • 著者名/発表者名: Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H
  • 雑誌名: Diabet.Res.Clin.Pract. 66 ページ: 163-171
• [雑誌論文] Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access. (2004)
  • 著者名/発表者名: Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A
  • 雑誌名: Mol.Pharmacol. 66 ページ: 330-336
• [雑誌論文] Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis (2003)
  • 著者名/発表者名: Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H
  • 雑誌名: Am J Hum Genet 72 ページ: 303-312
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Association study of the CD 14 polymorphism with myocardial infarction in Japanese populations (2003)
  • 著者名/発表者名: Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T
  • 雑誌名: Jpn Heart J 44 ページ: 613-622
  • NAID: 130000067313
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions (2003)
  • 著者名/発表者名: Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A
  • 雑誌名: Arter Thrombo Vasc Biol 23 ページ: 783-788
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese. (2003)
  • 著者名/発表者名: Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A
  • 雑誌名: MHC 9 ページ: 163-169
  • NAID: 130005509796
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis. (2003)
  • 著者名/発表者名: Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H
  • 雑誌名: Am J Hum Genet 72 ページ: 303-312
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Association study of the CD14 polymorphism with myocardial infarction in Japanese populations. (2003)
  • 著者名/発表者名: Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T
  • 雑誌名: Jpn Heart J 44 ページ: 613-622
  • NAID: 130000067313
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions. (2003)
  • 著者名/発表者名: Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A
  • 雑誌名: Arter Thrombo Vasc Biol 23 ページ: 783-788
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Titin mutations as the molecular basis for dilated cardiomyopathy (2002)
  • 著者名/発表者名: Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A
  • 雑誌名: Biochem Biophys Res Commun 291 ページ: 385-393
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease (2002)
  • 著者名/発表者名: Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A
  • 雑誌名: Cardiovasc Res 53 ページ: 348-354
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of HLA in children with gelatin allergy (2002)
  • 著者名/発表者名: Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S
  • 雑誌名: Tissue Antigens 59 ページ: 412-416
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene (2002)
  • 著者名/発表者名: Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M
  • 雑誌名: J Hum Genet 47 ページ: 330-332
  • NAID: 10011575172
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy (2002)
  • 著者名/発表者名: Knoll R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR
  • 雑誌名: Cell 111 ページ: 943-955
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy (2002)
  • 著者名/発表者名: Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M
  • 雑誌名: J Allergy Clin Immunol 110 ページ: 652-658
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese (2002)
  • 著者名/発表者名: Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A
  • 雑誌名: MHC 9 ページ: 163-169
  • NAID: 130005509796
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Titin mutations as the molecular basis for dilated cardiomyopathy. (2002)
  • 著者名/発表者名: Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A
  • 雑誌名: Biochem Biophys Res Commun 291 ページ: 385-393
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease. (2002)
  • 著者名/発表者名: Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A
  • 雑誌名: Cardiovasc Res 53 ページ: 348-354
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Analysis of HLA in children with gelatine allergy. (2002)
  • 著者名/発表者名: Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S
  • 雑誌名: Tissue Antigens 59 ページ: 412-416
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene. (2002)
  • 著者名/発表者名: Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M
  • 雑誌名: J Hum Genet 47 ページ: 330-332
  • NAID: 10011575172
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Clinical significance of T-wave alternans in hypertrophic cardiomyopathy. (2002)
  • 著者名/発表者名: Kuroda N, Ohnishi Y, Kimura A, Yokoyama M
  • 雑誌名: Circ J 66 ページ: 457-462
  • NAID: 110002682850
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. (2002)
  • 著者名/発表者名: Knoll R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR
  • 雑誌名: Cell 111 ページ: 943-955
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatine allergy. (2002)
  • 著者名/発表者名: Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M
  • 雑誌名: J Allergy Clin Immunol 110 ページ: 652-658
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit (2001)
  • 著者名/発表者名: Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A
  • 雑誌名: J Biol Chem. 276 ページ: 6073-6082
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region (2001)
  • 著者名/発表者名: Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H
  • 雑誌名: Genomics 71 ページ: 263-270
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4 (2001)
  • 著者名/発表者名: Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A
  • 雑誌名: Tissue Antigens 57 ページ: 520-535
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, are associated with myocardial infarction in Japanese (2001)
  • 著者名/発表者名: Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T
  • 雑誌名: Ann NY Acad Sci 947 ページ: 259-269
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese. (2001)
  • 著者名/発表者名: Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A
  • 雑誌名: Tissue Antigens 57 ページ: 66-69
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit. (2001)
  • 著者名/発表者名: Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A
  • 雑誌名: J Biol Chem. 276 ページ: 6073-6082
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region. (2001)
  • 著者名/発表者名: Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H
  • 雑誌名: Genomics 71 ページ: 263-270
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4. (2001)
  • 著者名/発表者名: Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A
  • 雑誌名: Tissue Antigens 57 ページ: 520-535
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, are associated with myocardial infarction in Japanese. (2001)
  • 著者名/発表者名: Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T
  • 雑誌名: Ann NY Acad Sci 947 ページ: 259-269
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis (2000)
  • 著者名/発表者名: Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F
  • 雑誌名: Int J Cardiol 75 ページ: 105-110
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen alpha2 chain (COL1A2) gene promoter (2000)
  • 著者名/発表者名: Akai J, Kimura A, Hata R
  • 雑誌名: Connective Tissue 32 ページ: 259-265
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Characterization of human nebulette gene : A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy (2000)
  • 著者名/発表者名: Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A
  • 雑誌名: Hum Genet 107 ページ: 440-451
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese (2000)
  • 著者名/発表者名: Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A
  • 雑誌名: Tissue Antigens 57 ページ: 66-69
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis. (2000)
  • 著者名/発表者名: Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F
  • 雑誌名: Int J Cardiol 75 ページ: 105-110
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen alpha 2 chain (COL1A2) gene promoter. (2000)
  • 著者名/発表者名: Akai J, Kimura A, Hata R
  • 雑誌名: Connective Tissue 32 ページ: 259-265
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Characterization of human nebulette gene : A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy. (2000)
  • 著者名/発表者名: Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A
  • 雑誌名: Hum Genet 107 ページ: 440-451
  • 説明: 「研究成果報告書概要(欧文)」より
• [図書] HLA2004 Immunobiology of the Human MHC (2005)
  • 著者名/発表者名: Kimura A, Takahashi M, Shibata H, Kobayashi Y, Obuchi N, Ota M, Inoko H, Numano F, Yasunami M
  • 出版者: (in press)
• [図書] HLA2004 Immunobiology of the Human MHC (2005)
  • 著者名/発表者名: Yasunami M, Shibata H, Shao WS, Takahashi M, Hamaguchi K, Sakata T, Ota M, Inoko H, Kimura A
  • 出版者: (in press)
• [図書] HLA2004 Immunobiology of the Human MHC (2005)
  • 著者名/発表者名: Takahashi M, Yasunami M, Tamai H, Kimura A
  • 出版者: (in press)
• [産業財産権] 変異型HCN4遺伝子 (2003)
  • 発明者名: 木村彰方, 上田和雄
  • 産業財産権番号: 2003-050469
  • 出願年月日: 2003-02-27
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] I型糖尿病の検査方法 (2001)
  • 発明者名: 木村彰方, 柴田宏樹, 安波道郎
  • 産業財産権番号: 2001-306868
  • 出願年月日: 2001-10-02
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Okamoto K, et al.: "Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis."Am.J.Hum.Genet.. 72. 303-312 (2003)
• [文献書誌] Shao W, et al.: "Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese."MHC. 9. 163-169 (2003)
• [文献書誌] Hohda S, et al.: "Association study of the CD14 polymorphism with myocardial infarction in Japanese populations."Jpn.Heart J.. 44. 613-622 (2003)
• [文献書誌] Yoshida M, et al.: "E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions."Arter.Thrombo.Vasc.Biol.. 23. 783-788 (2003)
• [文献書誌] Yamashita T, et al.: "IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese."Tissue Antigens. (in pres).
• [文献書誌] Hayashi T, et al.: "Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy."Biochem.Biophys.Res.Commun. 313. 178-184 (2004)
• [文献書誌] Arimura T, et al.: "A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C."J.Biol.Chem.. 279. 6746-6752 (2004)
• [文献書誌] Ogimoto A, et al.: "17-year follow-up study of apatient with obstructive hypertrophic cardiorayopathy with a deletion mutation in the cardiac myosin binding protein C gene."Circ J.. 68. 174-177 (2004)
• [文献書誌] Kimura A, et al.: "In HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(in press).
• [文献書誌] Yasunami M, et al.: "In HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(in press).
• [文献書誌] Takahashi M, et al.: "In HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(in press).
• [文献書誌] Kimura A, et al.: "In Cardiomyopathies and Heart Failure ; Biomolecular, Infectious and Immune Mechanisms (ed.Matsumori A)"Klumer Academic Publishers, Boston. 415-428 (2003)
• [文献書誌] Kimura A, et al.: "In Frontiers in Cardiovascular Health (eds.Dhalla NS, Chockalingam A, Berkovitz HI, Singal PK)"Klumer Academic Publishers, Boston. 195-206 (2003)
• [文献書誌] Sakaguchi M, et al.: "Analysis of HLA in children with gelatin allergy"Tissue Antigens. 59. 412-416 (2002)
• [文献書誌] Harada H, et al.: "Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene"J Hum. Genet. 47. 330-332 (2002)
• [文献書誌] Kuroda N, et al.: "Clinical significance of T-wave alternans in hypertrophic cardiomyopathy"Circ. J.. 66. 457-462 (2002)
• [文献書誌] Hori H, et al.: "Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy"J. Clin. Allergy Clin Immunol.. 110. 652-658 (2002)
• [文献書誌] Knoell R, et al.: "The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy"Cell. 111. 943-955 (2002)
• [文献書誌] Okamoto K, et al.: "Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis"Am. J. Hum. Genet.. (in press).
• [文献書誌] Shao W, et al.: "Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese"MHC. (印刷中).
• [文献書誌] Hohda S, et al.: "Association study of the CD14 polymorphism with myocardial infarction in Japanese populations"Jpn. Heart J. (印刷中).
• [文献書誌] Kimura A, et al.: "HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(印刷中).
• [文献書誌] Yasunami M, et al.: "HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(印刷中).
• [文献書誌] Takahashi M, et al.: "HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(印刷中).
• [文献書誌] Kimura A, et al.: "Proceedings of ICCHF (eds. Matsumori A, et al.)"Klumer Academic Publishers, Boston(印刷中).
• [文献書誌] Kimura A, et al.: "Frontiers in Cardiovascular Health (eds. Dhalla NS, et al.)"Klumer Academic Publishers, Boston(印刷中).
• [文献書誌] Obuchi N, Takahashi M, Nouchi T, et al.: "Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4"Tissue Antigens. 57. 520-535 (2001)
• [文献書誌] Kikuchi M, Looareesuwan S, Ubalee R, et al.: "Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais"Parasitol.Int.. 50. 235-239 (2001)
• [文献書誌] Sasaoka T, Kimura A, Hohta S, et al.: "Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly67OArg, are associated with myocardial infarction in Japanese"Ann NY Acad.Sci.. 947. 259-269 (2001)
• [文献書誌] Ubalee R, Suzuki F, Kikuchi M, et al.: "Strong association of a tumor necrosis factor-α promoter allele with cerebral malaria in Myanmar"Tissue Antigens. (in press).
• [文献書誌] Tsuchiya K, Kimura A, Kondo M, et al.: "Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis"Tissue Antigens. (in press).
• [文献書誌] Itoh-Satoh M, Hayashi T, Nishi H, et al.: "Titin mutations as the molecular basis for dilated cardiomyopathy"Biochem.Biophys.Res.Commun.. 291. 385-393 (2002)
• [文献書誌] Kimura A,Ota M,Katsuyama Y, et al.: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis."Int.J.Cardiol.. 75. S105-S110 (2000)
• [文献書誌] Takahashi M,Hashimoto H,Akizuki M, et al.: "Lack of associatin between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese."Tissue Antigens. 57. 66-69 (2001)
• [文献書誌] Arimura T,Suematsu N,Zhou YB, et al.: "Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit."J.Biol.Chem.. (in press).
• [文献書誌] Kimura A,Itoh-Satoh M,Hayashi T, et al.: "Molecular etiology of idiopathic cardiomyopathy in Asian populations."J Cardiol.. (in press).
• [文献書誌] M.Yoshida,L-J Chen,Y.Yasukochi, et al.: "Differenfiation-induced transmigration of HL60 cells across activated HUVEC monolayer involves E-selectin-dependent mechanism."Ann.N.Y.Acad.. 902. 307-310 (2000)
• [文献書誌] H.Ishii,M.Yoshida,A.Rosenzweig, et al.: "Adenoviral transduction of human E-selectin into isolated, perfused rat aortic segments : and ex vivo model for studying leukocyte-endothelial interactions."J.Leukocyte Biol.. 68. 687-692 (2000)