ヒトがんの発生・進展における遺伝子異常の解明、ならびにがん診療への応用

• 研究課題/領域番号: 12213010
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東北大学
• 研究代表者: 堀井 明 東北大学, 大学院医学系研究科, 教授 (40249983)
• 研究分担者: 八重樫 伸生 東北大学, 大学院医学系研究科, 教授 (00241597) ; 砂村 真琴 東北大学, 病院・講師 (10201584)
• 研究期間 (年度): 2000 – 2004
• 研究課題ステータス: 完了 (2004年度)
• 配分額: 64,100千円 (直接経費: 64,100千円); 2004年度: 12,400千円 (直接経費: 12,400千円); 2003年度: 13,600千円 (直接経費: 13,600千円); 2002年度: 14,000千円 (直接経費: 14,000千円); 2001年度: 13,100千円 (直接経費: 13,100千円); 2000年度: 11,000千円 (直接経費: 11,000千円)
• キーワード: 膵癌 / DUSP6 / AURKA / RNAi / マイクロアレイ / 悪性黒色腫 / BRAF / Wnt / 遺伝子治療 / アデノウイルス / MKP-3 / DNAミスマッチ修復異常 / 染色体12q / SMAD4 / 染色体18q / 酵母two-hybrid / 下垂体腺腫 / 18q / 1p36-p35 / BAI1 / RIZ / 膵がん / 遺伝子変異 / 神経芽細胞腫 / 1p / MSI

研究概要

膵癌において、1p、12q、18qの候補癌抑制遺伝子、ならびに20qの候補癌遺伝子の検討を加えた。1pでは、膵癌において、RBと結合するタンパクをコードするRIZの異常を明らかにした。12qでは、98年に同定した候補癌抑制遺伝子DUSP6についての解析を進めたところ、本遺伝子は初期病変では高発現しており、進展と伴に発現が落ちていくこと、アデノウイルスで高発現させるとアポトーシスが誘導されること、発現抑制の機序としてepigeneticな機構が重要であることを明らかにした。また、正常12番染色体を移入してもDUSP6の発現回復は見られないが、in vivoで増殖抑制効果が見られ、血管新生が抑制されることを検出した。18qの欠失も初期変化であるが、SMAD4に変異は見られず、SMAD4導入によってもでin vitro増殖抑制されないが、染色体移入ではin vitroで抑制され、転移も抑制された。20qは高頻度にコピー数の増加が見られるが、同部のAURKAは膵がんにおいて発現が亢進しており、RNAi法のノックダウンで細胞増殖抑制、G2 arrest、アポトーシスの誘導が見られ、taxaneの併用による相乗的抗腫瘍効果も見られた。
hMLH1はミスセンス変異が多く、病気の発生との関連を理解する上では、変異の機能評価が重要であるが、酵母のtwo-hybridによる簡便で正確な系を確立した。また、従来もっぱらDNA修復に関わると考えられていたMBD4の機能として、メチル化を解した転写抑制機構を明らかにした。下垂体腺腫ではβカテニンの異常集積が非常に高頻度に生じているが、遺伝子異常は低頻度である。また、Wntの経路に関わる遺伝子APC、AXIN1、GSK3B、ICAT遺伝子についても調べたが異常は見られず、これ以外の機序がかかわっている可能性が考えられた。日本人と欧米人では悪性黒色腫におけるBRAF遺伝子の変異の頻度が異なるが、これが人種による組織型の頻度の違いによるものである可能性を示した。

研究成果

• [雑誌論文] Comparative genomic hybridization and mutation analyses of sporadic schwannomas (2005)
  • 著者名/発表者名: Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A
  • 雑誌名: J Neuro-Oncol (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1 (2005)
  • 著者名/発表者名: Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A
  • 雑誌名: J Neuro-Oncol (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. (2005)
  • 著者名/発表者名: Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A
  • 雑誌名: Mod Pathol (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Computed tomographic images reflect the biological behavior of small lung adenocarcinoma; They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix and K-ras mutation. (2005)
  • 著者名/発表者名: Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T
  • 雑誌名: J Thorac Cardiovasc Surg (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (2005)
  • 著者名/発表者名: Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y
  • 雑誌名: Int J Cancer (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells (2005)
  • 著者名/発表者名: Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A
  • 雑誌名: Cancer Res 65 ページ: 2899-2905
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. (2005)
  • 著者名/発表者名: Xu S, Furukawa T, Kanai N, Sunamura M, Horii A
  • 雑誌名: J Hum Genet 50 ページ: 159-167
  • NAID: 10015696534
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16^<INK4a> and MLH1 genes. (2005)
  • 著者名/発表者名: Kondo E, Gu Z, Horii A, Fukushige S
  • 雑誌名: Mol Cell Biol 25 ページ: 4388-4396
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] In frequent mutation of APQ, AXIN1, and GSK3B In human pituitary adenomas with abnormal accumulation of CTNNBI. (2005)
  • 著者名/発表者名: Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A.
  • 雑誌名: J Neuro-Oncol (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. (2005)
  • 著者名/発表者名: Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A.
  • 雑誌名: Mod Pathol (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Comparative genomic hybridization and mutation analyses of sporadic schwannomas. (2005)
  • 著者名/発表者名: Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A.
  • 雑誌名: J Neuro-Oncol (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Computed tomographic images reflect the biological behavior of small lung adenocarcinoma; They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix and K-ras mutation. (2005)
  • 著者名/発表者名: Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T.
  • 雑誌名: J Thorac Cardiovasc Surg (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (2005)
  • 著者名/発表者名: Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y,. Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y.
  • 雑誌名: Int J Cancer (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The Role of DUSP6/MKP-3 in Pancreatic Carcinoma. In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3 : Molecular genetics, liver carcinoma, and pancreatic carcinoma (2005)
  • 著者名/発表者名: Furukawa T, Horii A.
  • 雑誌名: Elsevier (USA), Philadelphia, PA (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. (2005)
  • 著者名/発表者名: Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A.
  • 雑誌名: Cancer Res 65 ページ: 2899-2905
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Abrogation of DUSP6by hypermethylation in human pancreatic cancer. (2005)
  • 著者名/発表者名: Xu S, Furukawa T, Kanai N, Sunamura M, Horii A.
  • 雑誌名: J Hum Genet 50 ページ: 159-167
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p167NK4a and MLHI genes. (2005)
  • 著者名/発表者名: Kondo E, Gu Z, Horii A, Fukushige S.
  • 雑誌名: Mol Cell Biol 25 ページ: 4388-4396
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Infrequent mutation of APC, AXIN1,and GSK3B in human pituitary adenomas with abnormal accumulation of CTNINB1. (2005)
  • 著者名/発表者名: Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A.
  • 雑誌名: J Neuro-Oncol (in press)
• [雑誌論文] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. (2005)
  • 著者名/発表者名: Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A.
  • 雑誌名: Cancer Res (in press)
• [雑誌論文] Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. (2005)
  • 著者名/発表者名: Xu S, Furukawa T, Kanai N, Sunamura M, Horii A.
  • 雑誌名: J Hum Genet (in press)
  • NAID: 10015696534
• [雑誌論文] The thymine DNA glycosylase MBD4 represses transcription and associated with methylated p16^<INK4a> and MLH1 genes. (2005)
  • 著者名/発表者名: Kondo E, Gu Z, Horii A, Fukushige S.
  • 雑誌名: Mol Cell Biol (in press)
• [雑誌論文] DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (2004)
  • 著者名/発表者名: Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T
  • 雑誌名: Int J Oncol 24 ページ: 513-520
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin (2004)
  • 著者名/発表者名: Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T
  • 雑誌名: Biosci Biotecnnol Biochem 68 ページ: 1004-1010
  • NAID: 10013144409
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes. (2004)
  • 著者名/発表者名: Furukawa T, Horii A
  • 雑誌名: Pancreas 28 ページ: 253-256
  • NAID: 10016168077
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. (2004)
  • 著者名/発表者名: Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S
  • 雑誌名: Pancreas 28 ページ: 311-316
  • NAID: 10016168472
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Screening for functional tumor suppressor activity in pancreatic cancer. (2004)
  • 著者名/発表者名: Lefter L, Scripcaru V, Sunamura M, Furukawa T, Matsuno S, Oshimura M, Drug V, Dragomir C, Horii A
  • 雑誌名: Rom J Gastroenterol 13 ページ: 195-201
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. (2004)
  • 著者名/発表者名: Yatsuoka T, Furukawa T, Sunamura M, Matsuno S, Horii A
  • 雑誌名: Oncol Rep 12 ページ: 1263-1268
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. (2004)
  • 著者名/発表者名: Imai M, Nakamura T, Akiyama T, Horii
  • 雑誌名: Oncol Rep 12 ページ: 1099-1103
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis. (2004)
  • 著者名/発表者名: Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A
  • 雑誌名: Lab Invest 84 ページ: 1339-1351
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] BRAF point mutations in primary malignant melanoma show different prevalences by subtype. (2004)
  • 著者名/発表者名: Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A
  • 雑誌名: J Invest Dermatol 123 ページ: 177-183
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Functional Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes. (2004)
  • 著者名/発表者名: Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S
  • 雑誌名: Asian J Surg 27 ページ: 85-92
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes. (2004)
  • 著者名/発表者名: Furukawa, T., Horii, A.
  • 雑誌名: Pancreas 28 ページ: 253-256
  • NAID: 10016168077
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. (2004)
  • 著者名/発表者名: Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S.
  • 雑誌名: Pancreas 28 ページ: 311-316
  • NAID: 10016168472
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (2004)
  • 著者名/発表者名: Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T.
  • 雑誌名: Int J Oncol 24 ページ: 513-520
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin" (2004)
  • 著者名/発表者名: Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T.
  • 雑誌名: Biosci Biotecnnol Biochem 68 ページ: 1004-1010
  • NAID: 10013144409
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] BRAF point mutations in primary malignant melanoma show different prevalences by subtype " (2004)
  • 著者名/発表者名: Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.
  • 雑誌名: J Invest Dermatol 123 ページ: 177-183
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] FunctionalAnalysisofchromosome18inpancreaticcancer : strong evidence for new tumour suppressor genes. (2004)
  • 著者名/発表者名: Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S.
  • 雑誌名: Asian J Surg 27 ページ: 85-92
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis. (2004)
  • 著者名/発表者名: Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A.
  • 雑誌名: Lab lnvest 84 ページ: 1339-1351
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of (3).catenin. " (2004)
  • 著者名/発表者名: Imai M, Nakamura T, Akiyama T, Horii
  • 雑誌名: Oncol Rep 12 ページ: 1099-1103
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. (2004)
  • 著者名/発表者名: Yatsuoka T, Furukawa T, Sunamura M, Matsuno S, Horii A.
  • 雑誌名: Oncol Rep 12 ページ: 1263-1268
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] DSCP1,a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (2004)
  • 著者名/発表者名: Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T.
  • 雑誌名: Int J Oncol 24 ページ: 513-520
• [雑誌論文] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin (2004)
  • 著者名/発表者名: Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T.
  • 雑誌名: Biosci Biotecnnol Biochem 68 ページ: 1004-1010
  • NAID: 10013144409
• [雑誌論文] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes. (2004)
  • 著者名/発表者名: Furukawa T, Horii A.
  • 雑誌名: Pancreas 28 ページ: 253-256
  • NAID: 10016168077
• [雑誌論文] BRAF point mutations in primary malignant melanoma show different prevalences by subtype. (2004)
  • 著者名/発表者名: Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.
  • 雑誌名: J Invest Dermatol 123 ページ: 177-183
• [雑誌論文] Functional Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes. (2004)
  • 著者名/発表者名: Lefter LP, Sunamura M, Furukawa T, Yatsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S.
  • 雑誌名: Asian J Surg 27 ページ: 85-92
• [雑誌論文] Chromosome 12,frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis. (2004)
  • 著者名/発表者名: Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A.
  • 雑誌名: Lab Invest 84 ページ: 1339-1351
• [雑誌論文] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. (2004)
  • 著者名/発表者名: Imai M, Nakamura T, Akiyama T, Horii A.
  • 雑誌名: Oncol Rep 12 ページ: 1099-1103
• [雑誌論文] Screening for functional tumor suppressor activity in pancreatic cancer. (2004)
  • 著者名/発表者名: Lefter L, Scripcaru V, Sunamura M, Furukawa T, Matsuno S, Oshimura M, Drug V, Dragomir C, Horii A.
  • 雑誌名: Rom J Gastroenterol 13 ページ: 195-201
• [雑誌論文] Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast. (2003)
  • 著者名/発表者名: Aamari, M., Horiya, T., Ishida, T., Harada, Y., Ohnuki K., Takeda, M., Sasano, H., Horii, A., Ohuchi, N.
  • 雑誌名: Jpn J Clin Oncol 33 ページ: 556-562
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. (2003)
  • 著者名/発表者名: Lefter LP, Sunamura M, Furukawa T, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
  • 雑誌名: Clin Cancer Res 9 ページ: 5044-5052
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] APAF-l-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. (2003)
  • 著者名/発表者名: Ogawa T, Shiga K, Hashimoto S, Kobayashi T, Horii A, Furukawa T
  • 雑誌名: Biochem Biophys Res Commun 306 ページ: 537-543
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. (2003)
  • 著者名/発表者名: Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A
  • 雑誌名: Oncogene 22 ページ: 6857-6864
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations. (2003)
  • 著者名/発表者名: Kondo E, Suzuki H, Horii A, Fukushige S
  • 雑誌名: Cancer Res 63 ページ: 3302-3308
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. (2003)
  • 著者名/発表者名: Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A
  • 雑誌名: Am J Pathol 162 ページ: 1807-1815
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. (2003)
  • 著者名/発表者名: Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S, Kobayashi T, Ikeda T, Horii A, Monden M
  • 雑誌名: Oncol Rep 10 ページ: 35-38
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast. (2003)
  • 著者名/発表者名: Amari, M., Moriya, T., Ishida, T., Harada, Y., Ohnuki, K., Takeda, M., Sasano, H., Horii, A., Ohuchi, N.
  • 雑誌名: Jpn.J.Clin.Oncol. 33 ページ: 556-562
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. (2003)
  • 著者名/発表者名: Lefter, L.P., Sunamura, M., Furukawa, T., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A.
  • 雑誌名: Clin.Cancer Res. 9 ページ: 5044-5052
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. (2003)
  • 著者名/発表者名: Ogawa, T., Shiga, K., Hashimoto, S., Kobayashi, T., Horii, A., Furukawa, T.
  • 雑誌名: Biochem.Biophys.Res.Commun. 306 ページ: 537-543
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. (2003)
  • 著者名/発表者名: Duda, D.G., Sunamura, M., Lefter, L.P., Furukawa, T., Yokoyama, T., Yatsuoka, T., Abe, T., Inoue, H., Motoi, F., Egawa, S., Matsuno, S., Horii, A.
  • 雑誌名: Oncogene 22 ページ: 6857-6864
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations. (2003)
  • 著者名/発表者名: Kondo, E., Suzuki, H., Horii, A., Fukushige, S.
  • 雑誌名: Cancer Res. 63 ページ: 3302-3308
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. (2003)
  • 著者名/発表者名: Furukawa, T., Sunamura, M., Motoi, F., Matsuno, S., Horii, A.
  • 雑誌名: Am.J.Pathol. 162 ページ: 1807-1815
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. (2003)
  • 著者名/発表者名: Kadota, M., Tamaki, Y., Sekimoto, M., Fujiwara, Y., Aritake, N., Hasegawa, S., Kobayashi, T., Ikeda, T., Horii, A., Monden, M.
  • 雑誌名: Oncol.Rep. 10 ページ: 35-38
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus. (2002)
  • 著者名/発表者名: Sunamura M, Oonuma M, Motoi F, Abe H, Saito U, Hoshida T, Ottomo S, Horii A, Matsuno S
  • 雑誌名: Hum Cell 15 ページ: 138-150
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers (2002)
  • 著者名/発表者名: Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J
  • 雑誌名: Am J Pathol 161 ページ: 207-216
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A microarray-based method for detecting methylated loci. (2002)
  • 著者名/発表者名: Hatada I, Kato A, Morita S, Obata Y, Nagaoka K, Sakurada A, Sato M, Horii A, Tsujimoto A, Matsubara K
  • 雑誌名: J Hum Genet 47 ページ: 448-451
  • NAID: 50000580513
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (2002)
  • 著者名/発表者名: Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S
  • 雑誌名: Br J Cancer 86 ページ: 490-496
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. (2002)
  • 著者名/発表者名: Lefter LP, Furukawa T, Sunamura M, Duda D, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
  • 雑誌名: Genes Chromosomes Cancer 27 ページ: 234-242
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus. (2002)
  • 著者名/発表者名: Sunamura, M., Oonuma, M., Motoi, F., Abe, H., Saito, U., Hoshida, T., Ottomo, S., Horii, A., Matsuno, S.
  • 雑誌名: Hum.Cell 15 ページ: 138-150
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. (2002)
  • 著者名/発表者名: Yokoi, S., Yasui, K., Saito-Ohara, F., Koshikawa, K., Iizasa, T., Fujisawa, T., Terasaki, T., Horii, A., Takahashi, T., Hirohashi, S., Inazawa, J.
  • 雑誌名: Am.J.Pathol. 161 ページ: 207-216
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A microarray-based method for detecting methylated loci. (2002)
  • 著者名/発表者名: Hatada, I., Kato, A., Morita, S., Obata, Y., Nagaoka, K., Sakurada, A., Sato, M., Horii, A., Tsujimoto, A., Matsubara, K.
  • 雑誌名: J.Hum.Genet. 47 ページ: 448-451
  • NAID: 50000580513
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Overexpression of the p53-inducible brain-specific angiogenesis inhibitor l suppresses efficiently tumour angiogenesis. (2002)
  • 著者名/発表者名: Duda, D.G., Sunamura, M., Lozonschi, L., Yokoyama, T., Yatsuoka, T., Motoi, F., Horii, A., Tani, K., Asano, S., Nakamura, Y., Matsuno, S.
  • 雑誌名: Br.J.Cancer 86 ページ: 490-496
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. (2002)
  • 著者名/発表者名: Lefter, L.P., Furukawa, T., Sunamura, M., Duda, D.G., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A.
  • 雑誌名: Genes Chromosomes Cancer 27 ページ: 234-242
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 1 (2001)
  • 著者名/発表者名: Ishii S, Han S, Shiiba K, Mizoi T, Okabe M, Horii A, Nagura H, Matsuno S, Sasaki I
  • 雑誌名: Int J Clin Oncol 6 ページ: 201-204
  • NAID: 10009601119
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36. (2001)
  • 著者名/発表者名: Chen YZ, Soeda E, Yang HW, Takita J, Chai L, Horii A, Inazawa J, Ohki M, Hayashi Y
  • 雑誌名: Genes Chromosomes Cancer 31 ページ: 326-332
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease. (2001)
  • 著者名/発表者名: Kato N, Kimura K, Sugawara H, Aoyagi S, Ikeda T, Horii A
  • 雑誌名: Int J Oncol 18 ページ: 1017-1022
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1 and hPMS2. (2001)
  • 著者名/発表者名: Kondo E, Horii A, Fukushige S
  • 雑誌名: Nucl Acids Res 29 ページ: 1695-1702
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. (2001)
  • 著者名/発表者名: Kaneko K, Nagasaki Y, Furukawa T, Mizutamari H, Sato A, Masamune A, Shimosegawa T, Horii A
  • 雑誌名: J Hum Genet 46 ページ: 293-297
  • NAID: 50000889156
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A BAC-based STS-content map spanning a 35-megabase region of human chromosome 1p35-p36. (2001)
  • 著者名/発表者名: Chen YZ, Hayashi Y, Wu JG, Takaoka E, Haekawa K, Watanabe N, Inazawa J, Hosoda F, Arai Y, Ohki M, Mizushima H, Morohoshi A, Ohira H, Nakagawara A, Liu S-Y, Hoshi M, Horii A, Soeda, E
  • 雑誌名: Genomics 74 ページ: 55-70
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma. (2001)
  • 著者名/発表者名: Inoue H, Furukawa T, Sunamura M, Takeda K, Matsuno S, Horii A
  • 雑誌名: Genes Chromosomes Cancer 31 ページ: 295-299
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (2001)
  • 著者名/発表者名: Makino N, Yamato T, Inoue H, Furukawa T, Abe T, Yokoyama T, Yatsuoka T, Fukushige S, Orikasa S, Takahashi T, Horii A
  • 雑誌名: DNA Seq 11 ページ: 547-553
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Human BAC contig covering the deleted region in pancreatic cancer at 12q21. (2001)
  • 著者名/発表者名: Youssef EM, Kaneko K, Yatsuoka T, Hayashi Y, Hoshi M, Horii A, Furukawa T
  • 雑誌名: DNA Seq 11 ページ: 541-546
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. (2001)
  • 著者名/発表者名: Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A
  • 雑誌名: Genes Chromosomes Cancer 30 ページ: 207-211
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. (2001)
  • 著者名/発表者名: Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, Horii A
  • 雑誌名: Oncol Rep 8 ページ: 89-92
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] requent nuclear accumulation of β-catenin (CTNNB1) in human pituitary adenoma. (2001)
  • 著者名/発表者名: Semba S, Han S-Y, Ikeda H, Horii A
  • 雑誌名: Cancer 91 ページ: 42-48
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Report of the sixth international workshop on human chromosome 1 mapping 2000. (2001)
  • 著者名/発表者名: Schutte BC, Carpten JD, Forus A, Gregory SG, Horii A, White PS
  • 雑誌名: Cytogenet Cell Genet 92 ページ: 23-41
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Allelic loss of the NFI gene in anal malignant melanoma in a patient with neurofibromatosis type 1. (2001)
  • 著者名/発表者名: Ishii, S., Han, S., Shiiba, K., Mizoi, T., Okabe, M., Horii, A., Nagura, H., Matsuno, S., Sasaki, I.
  • 雑誌名: Int.J.Clin.Oncol. 6 ページ: 201-204
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band Ip36. (2001)
  • 著者名/発表者名: Chen, Y.Z., Soeda, E., Yang, H.W., Takita, J., Chai, L., Horii, A., Inazawa, J., Ohki, M., Hayashi, Y.
  • 雑誌名: Genes Chromosomes Cancer 31 ページ: 326-332
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease. (2001)
  • 著者名/発表者名: Kato, N., Kimura, K., Sugawara, H., Aoyagi, S., Ikeda, T., Horii, A.
  • 雑誌名: Int.J.Oncol. 18 ページ: 1017-1022
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1, and hPMS2. (2001)
  • 著者名/発表者名: Kondo, E., Horii, A., Fukushige, S.
  • 雑誌名: Nucl.Acids Res. 29 ページ: 1695-1702
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Analysis of the human pancreatic secretory trypsin inhibitor (PST1) gene mutations in Japanese patients with chronic pancreatitis. (2001)
  • 著者名/発表者名: Kaneko, K., Nagasaki, Y., Furukawa, T., Mizutamari, H., Sato, A., Masamune, A., Shimosegawa, T., Horii, A.
  • 雑誌名: J.Hum.Genet. 46 ページ: 293-297
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] ABAC-basedSTS-contentmapspanninga35-megabase region of human chromosome 1p35-p36. (2001)
  • 著者名/発表者名: Chen, Y.Z., Hayashi, Y., Wu, J.G., Takaoka, E., Maekawa, K., Watanabe, N., Inazawa, J., Hosoda, F., Arai, Y., Ohki, M., Mizushima, H., Morohoshi, A., Ohira, M., Nakagawara, A., Liu, S.-Y., Hoshi, M., Horii, A., Soeda, E.
  • 雑誌名: Genomics 74 ページ: 55-70
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma. (2001)
  • 著者名/発表者名: Inoue, H., Furukawa, T., Sunamura, M., Takeda, K., Matsuno, S., Horii, A.
  • 雑誌名: Genes Chromosomes Cancer 31 ページ: 295-299
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (2001)
  • 著者名/発表者名: Makino, N., Yamato, T, Inoue, H., Furukawa, T., Abe, T., Yokoyama, T., Yatsuoka, T., Fukushige, S., Orikasa, S., Takahashi, T., Horii, A.
  • 雑誌名: DNA Seq. 11 ページ: 547-553
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Human BAC contig covering the deleted region in pancreatic cancer at 12q21. (2001)
  • 著者名/発表者名: Youssef, E.M., Kaneko, K, Yatsuoka, T., Hayashi, Y, Hoshi, M., Horii, A., Furukawa, T.
  • 雑誌名: DNA Seq. 11 ページ: 541-546
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. (2001)
  • 著者名/発表者名: Sakurada, K., Furukawa, T., Kato, Y., Kayama, T., Huang, S., Horii, A.
  • 雑誌名: Genes Chromosomes Cancer 30 ページ: 207-211
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. (2001)
  • 著者名/発表者名: Sun, C., Yamato, T., Furukawa, T., Ohnishi, Y., Kijima, H., Horii, A.
  • 雑誌名: Oncol.Rep. 8 ページ: 89-92
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Frequent nuclear accumulation of (3)-catenin (CTNNBI) in human pituitary adenoma. (2001)
  • 著者名/発表者名: Semba, S., Han, S.-Y., Ikeda, H., Horii, A.
  • 雑誌名: Cancer 91 ページ: 42-48
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Report of the sixth international workshop on human chromosome l mapping 2000. (2001)
  • 著者名/発表者名: Schutte, B.C., Carpten, J.D., Forus, A., Gregory, S.G., Horii, A., White, P.S.
  • 雑誌名: Cytogenet.Cell Genet. 92 ページ: 23-41
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. (2000)
  • 著者名/発表者名: Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A
  • 雑誌名: J Hum Genet 45 ページ: 177-181
  • NAID: 10011570238
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma (2000)
  • 著者名/発表者名: Kadota M, Tamaki Y, Sakita I, Komoike Y, Miyazaki M, Ooka M, Hasuda N, Fujiwara Y, Ohnishi T, Tomita N, Sekimoto M, Ohue M, Ikeda T, Kobayashi T, Horii A, Monden M
  • 雑誌名: Oncol Rep 7 ページ: 529-533
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation (2000)
  • 著者名/発表者名: Ikeda T, Yoshinaga K, Semba S, Kondo E, Ohmori H, Horii A
  • 雑誌名: Oncol Rep 7 ページ: 323-326
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. (2000)
  • 著者名/発表者名: Hoshi M, Otagiri N, Shiwaku HO, Asakawa S, Shimizu N, Kaneko Y, Ohi R, Hayashi Y, Horii A
  • 雑誌名: Br J Cancer 82 ページ: 1801-1807
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. (2000)
  • 著者名/発表者名: Ikeda T, Yoshinaga K, Suzuki A, Sakurada A, Ohmori H, Horii A
  • 雑誌名: Oncol Rep 7 ページ: 567-570
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells. (2000)
  • 著者名/発表者名: Shinoura N, Muramatsu Y, Asai A, Han S, Horii A, Kirino T, Hamada H
  • 雑誌名: Cancer Lett 160 ページ: 67-73
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6(GlcNAcβ1-2) Manα1-R[GlcNAc to Man]β1, 4N-acetylglucosaminyltransferase VI. (2000)
  • 著者名/発表者名: Sakamoto Y, Taguchi T, Honke K, Korekane H, Watanabe H, Tano Y, Dohmae N, Takio K, Horii A, Taniguchi N
  • 雑誌名: J Biol Chem 275 ページ: 36029-36034
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. (2000)
  • 著者名/発表者名: Yuki M, Yoshinaga K, Yamakawa H, Sakurada K, Sato S, Yajima A, Horii A
  • 雑誌名: Oncol Rep 7 ページ: 1339-1342
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability. (2000)
  • 著者名/発表者名: Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S
  • 雑誌名: Cancer Res 60 ページ: 4701-4704
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability (2000)
  • 著者名/発表者名: Kondo E, Furukawa T, Yoshinaga K, Kijima H, Semba S, Yatsuoka T, Yokoyama T, Fukushige S, Horii A
  • 雑誌名: Int J Oncol 17 ページ: 535-541
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. (2000)
  • 著者名/発表者名: Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Shishikura T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Tomioka N, Sakiyama S, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa I, Nakagawara A
  • 雑誌名: Oncogene 19 ページ: 4302-4307
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma. (2000)
  • 著者名/発表者名: Nakagawara A, Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Shishikura T, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa, I, Sakiyama, S
  • 雑誌名: Med Pediat Oncol 35 ページ: 516-521
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss. (2000)
  • 著者名/発表者名: Hoshi M, Shiwaku HO, Hayashi Y, Kaneko Y, Horii A
  • 雑誌名: Med Pediat Oncol 35 ページ: 522-525
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma. (2000)
  • 著者名/発表者名: Mayama T, Fukushige S, Shineha R, Nishihira T, Satomi S, Horii A
  • 雑誌名: Int J Oncol 17 ページ: 245-252
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. (2000)
  • 著者名/発表者名: Semba S, Ouyang H, Han S-Y, Kato Y, Horii A
  • 雑誌名: Int J Oncol 16 ページ: 731-737
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. (2000)
  • 著者名/発表者名: Yatsuoka T, Sunamura M, Furukawa T, Fukushige S, Yokoyama T, Inoue H, Shibuya K, Takeda K, Hatsuno S, Horii A
  • 雑誌名: Am J Gastroent 95 ページ: 2080-2085
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells. (2000)
  • 著者名/発表者名: Shinoura, N., Muramatsu, Y., Asai, A., Han, S., Horii, A., Kirino, T., Hamada, H.
  • 雑誌名: Cancer Lett. 160 ページ: 67-73
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6(GlcNAcβ1-2)Mana1-R[GlcNActoMan]pi,4 N-acetylglucosaminyltransferase VI. (2000)
  • 著者名/発表者名: Sakamoto, Y., Taguchi, T., Honke, K., Korekane, H., Watanabe, H., Tano, Y., Dohmae, N., Takio, K, Horii, A., Taniguchi, N.
  • 雑誌名: J.Biol.Chem. 275 ページ: 36029-36034
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. (2000)
  • 著者名/発表者名: Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A.
  • 雑誌名: Oncol.Rep. 7 ページ: 1339-1342
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability. (2000)
  • 著者名/発表者名: Piao, Z., Fang, W., Malkhosyan, S., Kim, H., Horii, A., Perucho, M., Huang, S.
  • 雑誌名: Cancer Res. 60 ページ: 4701-4704
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Not hMSH2but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability. (2000)
  • 著者名/発表者名: Kondo, E., Furukawa, T., Yoshinaga, K., Kijima, H., Semba, S., Yatsuoka, T., Yokoyama, T., Fukushige, S., Horii, A.
  • 雑誌名: Int.J.Oncol. 17 ページ: 535-541
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss. (2000)
  • 著者名/発表者名: Hoshi, M., Shiwaku, H.O., Hayashi, Y., Kaneko, Y., Horii, A.
  • 雑誌名: Med.Pediat.Onco1. 35 ページ: 522-525
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification of the homozygously deleted region at chromosome Ip36.2 in human neuroblastoma. (2000)
  • 著者名/発表者名: Nakagawara, A., Ohira, M., Kageyama, H., Mihara, M., Furuta, S., Machida, T., Takayasu, H., Islam, A., Nakamura, Y., Takahashi, M., Shishikura, T., Kaneko, Y., Toyoda, A., Hattori, M., Sakaki, Y., Ohki, M., Horii, A., Soeda, E., Inazawa, J., Seki, N., Kuma, H., Nozawa, 1., Sakiyama, S.
  • 雑誌名: Med. Pediat. Onco1. 35 ページ: 516-521
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification and characterization of a 500-kb homozygously deleted region at Ip36.2-p36.3 in a neuroblastoma cell line. (2000)
  • 著者名/発表者名: Ohira, M., Kageyama, H., Mihara, M., Furuta, S., Machida, T., Shishikura, T., Takayasu, H., Islam, A., Nakamura, Y., Takahashi, M., Tomioka, N., Sakiyama, S., Kaneko, Y., Toyoda, A., Hattori, M., Sakaki, Y., Ohki, M., Horii, A., Soeda, E., Inazawa, J., Seki, N., Kuma, H., Nozawa, I., Nakagawara, A.
  • 雑誌名: 0ncogene 19 ページ: 4302-4307
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma. (2000)
  • 著者名/発表者名: Mayama, T., Fukushige, S., Shineha, R., Nishihira, T., Satomi, S., Horii, A.
  • 雑誌名: Int.J.Oncol. 17 ページ: 245-252
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. (2000)
  • 著者名/発表者名: Semba, S., Ouyang, H., Han, S.-Y., Kato, Y., Horii, A.
  • 雑誌名: Int.J.Oncol. 16 ページ: 731-737
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. (2000)
  • 著者名/発表者名: Yatsuoka, T., Sunamura, M., Furukawa, T., Fukushige, S., Yokoyama, T., Inoue, H., Shibuya, K., Takeda, K., Matsuno, S., Horii, A.
  • 雑誌名: Am.J.Gastroent. 95 ページ: 2080-2085
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. (2000)
  • 著者名/発表者名: Ikeda, T., Yoshinaga, K., Suzuki, A., Sakurada, A., Ohmori, H., Horii, A.
  • 雑誌名: Oncol.Rep. 7 ページ: 567-570
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] p24/INGI ALTI and p47/ING1 ALTZ, distinct alternative transcripts of p33/INGI. (2000)
  • 著者名/発表者名: Saito, A., Furukawa, T., Fukushige, S., Koyama, S., Hoshi, M., Hayashi, Y., Horii, A.
  • 雑誌名: J.Hum.Genet. 45 ページ: 177-181
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma. (2000)
  • 著者名/発表者名: Kadota, M., Tamaki, Y., Sakita, 1., Komoike, Y., Miyazaki, M., Ooka, M., Masuda, N., Fujiwara, Y., Ohnishi, T., Tomita, N., Sekimoto, M., Ohue, M., Ikeda, T., Kobayashi, T., Horii, A., Monden, M.
  • 雑誌名: Oncol.Rep. 7 ページ: 529-533
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation. (2000)
  • 著者名/発表者名: Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A.
  • 雑誌名: Oncol.Rep. 7 ページ: 323-326
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. (2000)
  • 著者名/発表者名: Hoshi, M., Otagiri, N., Shiwaku, H.O., Asakawa, S., Shimizu, N., Kaneko, Y., Ohi, R., Hayashi, Y., Horii, A.
  • 雑誌名: Br.J.Cancer 82 ページ: 1801-1807
  • 説明: 「研究成果報告書概要(欧文)」より
• [図書] The Role of DUSP6/HKP-3 in Pancreatic Carcinoma. In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3 : Molecular genetics, liver carcinoma, and pancreatic carcinoma (2005)
  • 著者名/発表者名: Furukawa T, Horii A
  • 出版者: Elsevier (USA), Philadelphia, PA(in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [図書] The Role of DUSP6/MKP-3 in Pancreatic Carcinoma In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3: Molecular genetics, liver carcinoma, and pancreatic carcinoma. (2005)
  • 著者名/発表者名: Furukawa T, Horii A.
  • 出版者: Elsevier (USA), Philadelphia, PA (in press)
• [文献書誌] Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.: "BRAF point mutations in primary malignant melanoma show different prevalences by subtype."J.Invest.Dermatol.. in press. (2004)
• [文献書誌] Furukawa T, Horii A.: "Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes."Pancreas. in press. (2004)
• [文献書誌] Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S: "The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma."Pancreas. in press. (2004)
• [文献書誌] Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S: "Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes."Asian J.Surg.. in press. (2004)
• [文献書誌] Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T: "A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin."Biosci.Biotecnnol.Biochem.. in press. (2004)
• [文献書誌] Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T: "DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro."Int J Oncol.. 24. 513-520 (2004)
• [文献書誌] Amari M, Moriya T, Ishida T, Harada Y, Ohnuki K, Takeda M, Sasano H, Horii A, Ohuchi N: "Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast."Jpn.J.Clin.Oncol.. 33. 556-562 (2003)
• [文献書誌] Lefter LP, Sunamura M, Furukawa T, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A: "Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype."Clin Cancer Res.. 9. 5044-5052 (2003)
• [文献書誌] Kondo E, Suzuki H, Horii A, Fukushige S: "A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations."Cancer Res. 63. 3302-3308 (2003)
• [文献書誌] Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A: "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer."Am.J.Pathol. 162. 1807-1815 (2003)
• [文献書誌] Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S, Kobayashi T, Ikeda T, Horii A, Monden M: "Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma."Oncol.Rep. 10. 35-38 (2003)
• [文献書誌] Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A: "Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatric adenocarcinoma cells."Oncogene. 22. 6857-6864 (2003)
• [文献書誌] Ogawa T, Shiga K, Hashimoto S, Kobayashi T, Horii A, Furukawa T: "APAF-1-ALT, A Novel Alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line."Biochem.Biophys.Res.Commun.. 306. 537-543 (2003)
• [文献書誌] Furukawa, T., Sunamura, M., Horii, A., et al.: "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer"Am.J.Pathol.. (in press).
• [文献書誌] Kondo, E., Horii, A., et al.: "Yeast two-hybrid assay provides a simple way to evaluate a vast majority of hMLH1 germline mutations"Cancer Res.. (in press).
• [文献書誌] Kadota, M., Horii, A.et al.: "Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma"Oncol.Rep.. 10. 35-38 (2003)
• [文献書誌] Hatada, I., Horii, A.et al.: "A microarray-based method for detecting methylated loci"J.Hum.Genet.. 47. 448-451 (2002)
• [文献書誌] Lefter, L.P., Sunamura, M., Horii, A.et al.: "Suppression of the tumorigenic phenotype by chromosome 18transfer into pancreatic cancer cell lines"Genes Chromosomes Cancer. 27. 234-242 (2002)
• [文献書誌] Yokoi, S., Horii, A.et al.: "A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers"Am.J.Pathol.. 161. 207-216 (2002)
• [文献書誌] Duda, D.G., Sunamura, M., Horii, A.et al.: "Brain specific angiogenesis inhibitor 1 mediates the p53 inhibitory effect on tumor angiogenesis by the downregulation of collagenase expression"Br.J.Cancer. 86. 490-496 (2002)
• [文献書誌] Sunamura, M., et al.: "Gene therapy for pancreatic cancer based on its genetic characterization"J.Hep.Bil.Pancreat.Surg.. 9. 32-38 (2002)
• [文献書誌] Mikami, Y., Sunamura, M., et al.: "Peritoneal inflammatory cells in acute pancreatitis : Relationship of infiltration dynamics and cytokine production with severity of illness"Surgery. 132. 86-92 (2002)
• [文献書誌] Hoshida, T., Sunamura, M., et al.: "Gene Therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor"Pancreas. 25. 111-121 (2002)
• [文献書誌] Oonuma, M., Sunamura, M.et al.: "Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli Uracil Phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors"Int.J.Cancer. 102. 51-59 (2002)
• [文献書誌] Kadowaki, M., Yaegashi, N.et al.: "Prediction of the effects of gonadotropin-releasing hormone agonist therapy in uterine leiomyoma by contrast-enhanced magnetic resonance imaging sequences"Fertil.Steril.. 5. 1081-1082 (2002)
• [文献書誌] Yokomizo, R., Yaegashi, N.et al.: "Erythropoietin and erythropoietin receptor expresiion in human endometrium throughout the menstrual cyst"Mol.Hum.Reproduct.. 8. 441-446 (2002)
• [文献書誌] Semba, S: "Frequent nuclear accumulation of b-catenin (CTNNB1) in human pituitary adenoma"Cancer. 91. 42-48 (2001)
• [文献書誌] Sun, C.: "Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines"Oncol. Rep.. 8. 89-92 (2001)
• [文献書誌] Sakurada, K.: "RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum"Genes Chromosomes Cancer. 30. 207-211 (2001)
• [文献書誌] Youssef, E.M.: "Human BAC contig covering the deleted region in pancreatic cancer at 12q21"DNA Seq.. 11. 541-546 (2001)
• [文献書誌] Makino, N.: "Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer"DNA Seq.. 11. 547-553 (2001)
• [文献書誌] Inoue, H.: "Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma"Genes Chromosomes Cancer. 31. 295-299 (2001)
• [文献書誌] Chen, Y.Z.: "A BAC-based STS-content map spanning a 35-megabase region of human chromosome 1p35-36"Genomics. 74. 55-70 (2001)
• [文献書誌] Kaneko, K.: "Analysis of the human pancreatic secretory trypsin inhibitor (PST1) gene mutations in Japanese patients with chronic pancreatitis"J. Hum. Genet.. 46. 293-297 (2001)
• [文献書誌] Kondo, E.: "The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1, and hPMS2"Nucl. Acids Res.. 29. 1695-1702 (2001)
• [文献書誌] Kato, N.: "Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease"Int. J. Oncol.. 18. 1017-1022 (2001)
• [文献書誌] Chen, Y.Z.: "Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36"Genes Chromosomes Cancer. 31. 326-332 (2001)
• [文献書誌] Ishii, S.: "Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 1"Int. J. Clin. Oncol.. 6. 201-204 (2001)
• [文献書誌] Lefter, L.P.: "Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines"Genes Chromosomes Cancer. (in press).
• [文献書誌] Duda, D.G.: "Overexpression of the p53-inducibIe brain-specific angiogenesis inhibitor 1 suppresses efficiently tumor angiogenesis"Br. J. Cancer. (in press).
• [文献書誌] Hoshi,M. et al.: "Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss."Br.J.Cancer. 82. 1801-1807 (2000)
• [文献書誌] Ikeda,T. et al.: "Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation."Oncol.Rep.. 7. 323-326 (2000)
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