器官形成・再生システムにおける情報伝達のダイナミクス

• 研究課題/領域番号: 13044002
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 首都大学東京
• 研究代表者: 八杉 貞雄 首都大学東京, 都市教養学部, 教授 (70011591)
• 研究分担者: 浅島 誠 東京大学, 大学院総合文化研究科, 教授 (00090564) ; 黒岩 厚 名古屋大学, 大学院理学研究科, 教授 (20134611) ; 小椋 利彦 東北大学, 加齢医学研究所, 教授 (60273851) ; 多羽田 哲也 東京大学, 分子細胞生物学研究所, 教授 (10183865) ; 阿形 清和 理化学研究所, 発生・再生科学総合研究センター, グループディレクター (70167831)
• 研究期間 (年度): 2001 – 2005
• 研究課題ステータス: 完了 (2005年度)
• 配分額: 511,400千円 (直接経費: 511,400千円); 2005年度: 85,900千円 (直接経費: 85,900千円); 2004年度: 85,100千円 (直接経費: 85,100千円); 2003年度: 112,500千円 (直接経費: 112,500千円); 2002年度: 112,500千円 (直接経費: 112,500千円); 2001年度: 115,400千円 (直接経費: 115,400千円)
• キーワード: 器官形成 / 組織間相互作用 / シグナル伝達機構 / 成長因子 / 転写因子 / 細胞分化 / 再生医療 / マイクロアレイ / シグナル伝達 / 細胞・組織 / 再生医学 / 発生・分化 / 再生 / 遺伝子カスケード / 情報伝達 / 形態形成物質

研究概要

各器官の形成における遺伝子発現ネットワークのより詳細な解析が行われた。(阿形)プラナリアにおいて新規にnoggin様遺伝子2種を同定し、noggin/BMPシグナル系がDV軸のみならずML軸にも関与していることを示した。また、新規nou-darakeファミリー遺伝子3種がクローニングされて、これらが体の前方部の位置情報を担っていることが明らかになった。(浅島)ツメガエルを用いて新規心臓形成関連因子MA35の単離及び機能解析、SUMO化修飾の機能解析、初期発生におけるWntシグナル伝達経路の解析が行われ、初期発生と器官形成に新しい知見をもたらした。(小椋)哺乳類におけるTbx5遺伝子の転写制御に必要な因子を複数単離し、それに関連する遺伝子を網羅的に単離してセブラフィッシュでノックダウンの実験を行なった。その結果、endocytosisとEphBリセプターとの機能的な関連、細胞骨格との相関が認められ、転写活性化と細胞骨格との関連が明らかになった。(黒岩)四肢軟骨パターン形成過程で、Hox遺伝子群は肢芽間充織からの前軟骨凝集塊形成の位置特性を決定していること、Hoxの標的遺伝子破壊マウスとトランスジェニックマウスを用いて、ephrin-b1およびEphB2がHox下流細胞接着制御因子として機能していることが見いだされた。(多羽田)ショウジョウバエの最外側の視覚中枢であるラミナにおいて、JAK/STATシグナルを抑制すると、ラミナ神経はより内側のメダラ神経の発生運命をたどることが明らかとなった。Notchシグナルを抑制しても同様の表現型が観察されることから、両シグナルは神経幹細胞からの多段階分化を制御しているものと考えられる。(八杉)消化器官についてWnt5aが上皮の細胞分化に深く関わることが示された。Wnt5aを過剰発現されたニワトリ腺胃上皮では領域特異的遺伝子発現に異常が生じて異所的発現や過剰発現が観察された。さらに、腺上皮で特異的に発現する複数の遺伝子についてその発現調節機構が解析された。

研究成果

• [雑誌論文] DWnt4 regulates dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. (2006)
  • 著者名/発表者名: Sato, M., Umetsu, D., Murakami, S., Yasugi, T., Tabata,.
  • 雑誌名: Nature Neurosci. 9 ページ: 67-75
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. (2006)
  • 著者名/発表者名: Osafune, K., Takasato, M., Kispert, A., Asashima, M., Nishinakamura, R.
  • 雑誌名: Development 133(1) ページ: 151-161
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. (2006)
  • 著者名/発表者名: Sato, M., Umetsu, D., Murakami, S., Yasugi, T., *Tabata, T.
  • 雑誌名: Nature Neurosci. 9 ページ: 67-75
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. (2006)
  • 著者名/発表者名: Osafune, K., Takasato, M., Kispert, A., Asashima, M., *Nishinakamura, R.
  • 雑誌名: Development 133(1) ページ: 151-161
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila visual system. (2006)
  • 著者名/発表者名: Sato, M.
  • 雑誌名: Nature Neuroscience 9 ページ: 67-75
• [雑誌論文] Highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in Drosophilavisual system. (2006)
  • 著者名/発表者名: Umetsu, D.
  • 雑誌名: Development 133 ページ: 791-800
• [雑誌論文] Expression and function of Wnt5a in the development of the glandular stomach in chicken embryo. (2006)
  • 著者名/発表者名: Listyorini, D.
  • 雑誌名: Dev.Growth & Differ.
• [雑誌論文] FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo. (2006)
  • 著者名/発表者名: Shin, M.
  • 雑誌名: Dev.Biol.
• [雑誌論文] Fate and plasticity of the endoderm in the early chick embryo. (2006)
  • 著者名/発表者名: Kimura, W.
  • 雑誌名: Dev.Biol. 289 ページ: 283-295
• [雑誌論文] Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. (2006)
  • 著者名/発表者名: Goto, T.
  • 雑誌名: Current Biology 15 ページ: 787-793
• [雑誌論文] Molecular genetic cascades for external genitalia formation : an emerging organogenesis program. (2006)
  • 著者名/発表者名: Yamada, G.
  • 雑誌名: Dev.Dyn. (in press)
• [雑誌論文] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. (2005)
  • 著者名/発表者名: Matsuda, Y., Wakamatsu, Y., Kohyama, J., Okano, H., Fukuda, K., Yasugi, S.
  • 雑誌名: Development 132 ページ: 2783-2793
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Notch signaling modulates the unclear localization of carboxyl-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activen A. (2005)
  • 著者名/発表者名: Abe, T., Furue, M., Kondow, A., Matsuzaki, K., Asashima, M.
  • 雑誌名: Mech.Dev. 122 ページ: 671-680
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in Drosophilavisual system. (2005)
  • 著者名/発表者名: Umetsu, D., Murakami, S., Sato, M.Tabata, T.
  • 雑誌名: Development 133 ページ: 791-800
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Requirements of genetic interactions between Src42A, armadillo and (2005)
  • 著者名/発表者名: Takahashi, M., Takahashi, F., Ui-Tei, K., Kojima, T., Saigo, K.
  • 雑誌名: Development 132 ページ: 2547-2559
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Asymmetric cortical and nuclear localizations of WRM1/b-catenin during asymmetric cell division in C.elegans. (2005)
  • 著者名/発表者名: Takeshita, H., Sawa, H.
  • 雑誌名: Genes Dev. 19 ページ: 1743-1748
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Potentiation of the ligand-binding activity of integrin alpha3etal via association with tetraspanin CD151. (2005)
  • 著者名/発表者名: Nishiuchi, R., Sanzen, N., Nada, S., Wada, Y., Takagi, J., Okada, M., Hasegawa, H., Sekiguchi, K.
  • 雑誌名: Proc.Natl.Acad.Sci.USA 102 ページ: 1934-1944
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. (2005)
  • 著者名/発表者名: Morimoto, M., Takahashi, Y., Endo, M., Saga, Y.
  • 雑誌名: Nature 435 ページ: 354-359
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. (2005)
  • 著者名/発表者名: Takahashi, T., Hatta, M., Yum, S., Koizumi, O., Kobayakawa, Y., Gee, L., Ohtani, M., Fujisawa, T., Bode, H.R.
  • 雑誌名: Development 132 ページ: 2225-2234
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A Drosophila model of congenital disorder of glycosylation IIc implicates the deficiency of Notch signaling in its pathogenesis. (2005)
  • 著者名/発表者名: Ishikawa, H.O., Higashi, S., Ayukawa, T., Sasamura, T., Aoki, K., Ishida N., Sanai, Y., Matsuno, K.
  • 雑誌名: Proc.Natl.Acad.Sci.USA 102 ページ: 18532-18537
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. (2005)
  • 著者名/発表者名: Yoshioka, H., Ishimaru, Y., Sugiyama, N., Tsunekawa, N., Noce, T., Kasahara, M., Morohashi, K.
  • 雑誌名: Dev.Biol. 280 ページ: 150-161
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. (2005)
  • 著者名/発表者名: Matsuda, Y., Wakamatsu, Y., Kohyama, J., Okano, H., Fukuda, K., *Yasugi, S.
  • 雑誌名: Development 132 ページ: 2783-2793
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] signaling modulates the nuclear localization of carboxyl-terminal- phosphorylated smad2 and controls the competence of ectodermal cells for activ in A. (2005)
  • 著者名/発表者名: Abe, T., Fume, M., Kondow, A., Matsuzaki, K., *Asashima.M.Notch
  • 雑誌名: Mech. Dev. 122 ページ: 671-680
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in Drosophilavisual system. (2005)
  • 著者名/発表者名: Umetsu, D., Murakami, S., Sato, M., *Tabata, T.
  • 雑誌名: Development 133 ページ: 791-800
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. (2005)
  • 著者名/発表者名: Takahashi, M., Takahashi, F., Ui-Tei, K., Koiima.T.., *Saigo, K.
  • 雑誌名: Development 132 ページ: 2547-2559
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Asymmetric cortical and nuclear localizations of WRM1/b-catenin during asymmetric cell division in C. elegans. (2005)
  • 著者名/発表者名: Takeshita, H., *Sawa, H.
  • 雑誌名: Genes Dev. 19 ページ: 1743-1748
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Potentiation of the ligand-binding activity of integrin alpha3etal via association with tetraspanin CD151. (2005)
  • 著者名/発表者名: Nishiuchi, R., Sanzen, N., Nada, S., Wada, Y., Takagi, J., Okada, M., Hasegawa, H., *Sekiguchi, K.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 102 ページ: 1934-1944
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. (2005)
  • 著者名/発表者名: Morimoto, M., Takahashi, Y., Endo, M., *Saga, Y.
  • 雑誌名: Nature 435 ページ: 354-359
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. (2005)
  • 著者名/発表者名: Takahashi, T., Hatta, M., Yum, S., Koizumi, 0., Kobayakawa, Y., Gee, L., Ohtani, M., Fujisawa, T., *Bode, H.R.
  • 雑誌名: Development 132 ページ: 2225-2234
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A Drosophila model of congenital disorder of glycosylation He implicates the deficiency of Notch signaling in its pathogenesis. (2005)
  • 著者名/発表者名: Ishikawa, H.0., Higashi, S., Ayukawa, T, Sasamura, T., Aoki, K., Ishida N., Sanai, Y., *Matsuno, K.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 102 ページ: 18532-1537
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. (2005)
  • 著者名/発表者名: Yoshioka, H., Ishimaru, Y., Sugiyama, N., Tsunekawa, N., Noce, T., Kasahara, M., Morohashi, K.
  • 雑誌名: Dev. Biol. 280 ページ: 150-161
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila. (2005)
  • 著者名/発表者名: Yoshida, S.
  • 雑誌名: Development 132 ページ: 4587-4598
• [雑誌論文] Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs. (2005)
  • 著者名/発表者名: Hojo, M.
  • 雑誌名: Gene Expression Patterns 6 ページ: 171-179
• [雑誌論文] Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. (2005)
  • 著者名/発表者名: Shin, M.
  • 雑誌名: Gene Expression Patterns 5 ページ: 511-516
• [雑誌論文] Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse. (2005)
  • 著者名/発表者名: Asai, E.
  • 雑誌名: Dev.Growth & Differ. 47 ページ: 501-510
• [雑誌論文] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development (2005)
  • 著者名/発表者名: Matsuda, Y.
  • 雑誌名: Development 132 ページ: 2783-2793
• [雑誌論文] Sex-specific and left-right asymmetric expression pattern of Bmp7 in the gonad of normal and sex-reversed chicken embryos. (2005)
  • 著者名/発表者名: Hoshino, A.
  • 雑誌名: Dev.Growth Differ. 47 ページ: 65-74
• [雑誌論文] Neural Projection in Planarian Brain Revealed by Fluorescent Dye Tracing. (2005)
  • 著者名/発表者名: Okamoto, K.
  • 雑誌名: Zool.Sci. 22 ページ: 535-546
• [雑誌論文] Temporal and spatial manipulation of gene expression in Xenopus embryos by injection of heat shockpromoter-containing plasmids. (2005)
  • 著者名/発表者名: Michiue, T.
  • 雑誌名: Developmenta Dynamics 232 ページ: 369-376
• [雑誌論文] Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embyos. (2005)
  • 著者名/発表者名: Tao, Q
  • 雑誌名: Cell 120 ページ: 857-871
• [雑誌論文] Notch signaling modulates the nuclear localization of carboxyl-terminalphosphorylated smad2 and controls the competence of ectodermal cells for activin A. (2005)
  • 著者名/発表者名: Abe, T.
  • 雑誌名: Mechanisms of Development 122 ページ: 671-680
• [雑誌論文] The role of XTRAP-gamma in Xenopus pronephros development. (2005)
  • 著者名/発表者名: Li, D
  • 雑誌名: Int.J.Dev.Biol 49 ページ: 401-408
• [雑誌論文] RXR agonist enhances the differentiation of cardiomyocytes derived from embryonic stem cells in serum-free conditions. (2005)
  • 著者名/発表者名: Honda, M.
  • 雑誌名: B.B.R.C. 333 ページ: 1334-1340
• [雑誌論文] Novel Daple-like protein positively regulates both the Wnt/b-catenin pathway and the Wnt/JNK pathway in Xenopus. (2005)
  • 著者名/発表者名: Kobayasni, H.
  • 雑誌名: Mechanisms of Development 122 ページ: 1138-1153
• [雑誌論文] Induction of cells expressing vascular endothelium markers from undifferentiated Xenopus presumptive ectoderm by co-treatment with activin and angiopoietin-2. (2005)
  • 著者名/発表者名: Nagamine, K.
  • 雑誌名: Zoological Science 22 ページ: 755-761
• [雑誌論文] Chromatin-related proteins in pluripotent mouse embryonic stem cells are downregulated after removal of leukemia inhibitory factor. (2005)
  • 著者名/発表者名: Kurisaki, A.
  • 雑誌名: B.B.R.C. 335 ページ: 667-675
• [雑誌論文] XBtg2 is required for notochord differentiation during early Xenopus development. (2005)
  • 著者名/発表者名: Sugimoto, K.
  • 雑誌名: Develop.Growth Differ. 47 ページ: 435-443
• [雑誌論文] Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled. (2005)
  • 著者名/発表者名: Onuma, Y.
  • 雑誌名: Developmental Dynamics 234 ページ: 900-910
• [雑誌論文] tructure and sequential gene expression of in vitro-induced pronephros (kidney) in the amphibian development (2005)
  • 著者名/発表者名: Asashima, M.
  • 雑誌名: Kidney International 68 ページ: 1963-1963
• [雑誌論文] Identification of multipotent progenitors in the embryonic mouse kidney by a novel colonyforming assay (2005)
  • 著者名/発表者名: Osafune, K.
  • 雑誌名: Development 133 ページ: 151-161
• [雑誌論文] Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. (2005)
  • 著者名/発表者名: Azuma N
  • 雑誌名: Hum Mol Genet. 14 ページ: 1059-1068
• [雑誌論文] The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure. (2005)
  • 著者名/発表者名: Azuma N
  • 雑誌名: Hum Mol Genet. 14 ページ: 735-745
• [雑誌論文] Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells. (2005)
  • 著者名/発表者名: Matsuura, R.
  • 雑誌名: Stem Cells 24
• [雑誌論文] Temporal and spatial manipulation of gene expression in Xenopus embryos by injection of heat shock promoter-containing plasmids (2005)
  • 著者名/発表者名: Michiue, T.
  • 雑誌名: Developmental Dynamics 232 ページ: 369-376
• [雑誌論文] Sex-specific and left-right asymmetric expression of BMP7 in the gonad of normal and sex-reversed chicken embryos (2005)
  • 著者名/発表者名: Hoshino, A.
  • 雑誌名: Devlop.Growth Differ. 47(in press)
• [雑誌論文] Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach (2005)
  • 著者名/発表者名: Shin, M.
  • 雑誌名: Gene Expression Patterns (in press)
• [雑誌論文] The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure (2005)
  • 著者名/発表者名: Azuma, N.
  • 雑誌名: Hum.Mol.Genet. 27(in press)
• [雑誌論文] Six1 controls patterning of the mouse otic vesible. (2004)
  • 著者名/発表者名: Ozaki, H., Nakamura, K., Funahashi, J., Ikeda, K., Yamada, G., Tokano, H., Okamura, H.O., Kitamura, K., Muto, S., Kotaki, H., Sudo, K., Horai, R., Iwakura, Y., Kawakami, K.
  • 雑誌名: Development 131 ページ: 551-564
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Misrouting of mitral cell progenitors in the Pax6/Small eyerat telencephalon. (2004)
  • 著者名/発表者名: Nomura, T., Osumi, N.
  • 雑誌名: Development 131 ページ: 787-796
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. (2004)
  • 著者名/発表者名: Hori, K., Fostier, M., Ito, M., Fuwa, J.T., Go, M., Okano, H., Martin Baron, M., Matsuno, K.
  • 雑誌名: Development 131 ページ: 5527-5537
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo. (2004)
  • 著者名/発表者名: Hiramatsu, H., Yasugi, S.
  • 雑誌名: Int.J.Dev.Biol. 48 ページ: 1141-1148
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Morphogens, their identification and regulation. (2004)
  • 著者名/発表者名: Tabata, T., Takei, Y.
  • 雑誌名: Development 131(4) ページ: 703-712
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Expression patterns of Xenopus FGF receptor-like 1/nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8. (2004)
  • 著者名/発表者名: Hayashi, S., Itoh, M., Taira, S., Agata, K., Taira, M.
  • 雑誌名: Dev.Dyn. 230 ページ: 700-707
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. (2004)
  • 著者名/発表者名: Kojima, T., Tsuji, T., Saigo, K.
  • 雑誌名: Dev.Biol. 279 ページ: 434-445
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Molecular dissection of the alpha-dystroglycanand integrin-binding sites within the globular domain of human laminin-10. (2004)
  • 著者名/発表者名: Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A.C., Ervasti, J.M., Sekiguchi, K.
  • 雑誌名: J.Biol.Chem. 279 ページ: 10946-10954
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. (2004)
  • 著者名/発表者名: Usui, M., Noda, M.
  • 雑誌名: Proc.Natl.Acad.Sci.USA 101 ページ: 6653-6658
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The ACR4 receptor-like kinase is required for surface formation of epidermis-related tissues in Arabidopsis thaliana. (2004)
  • 著者名/発表者名: Watanabe, M., Tanaka, H., Machida, C.Watanabe, D., Machida, Y
  • 雑誌名: Plant J. 39 ページ: 298-308
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Six 1 controls patterning of the mouse otic vesible. (2004)
  • 著者名/発表者名: Ozaki, H., Nakamura, K., Funahashi, J., Ikeda, K., Yamada, G., Tokano, H., Okamura, H.O., Kitamura, K., Muto, S., Kotaki, H., Sudo, K., Horai, R., Iwakura, Y., *Kawakami, K.
  • 雑誌名: Development 131 ページ: 551-564
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Misrouting of mitral cell progenitors in the Pax6/Small eye rat telencephalon. (2004)
  • 著者名/発表者名: Nomura, T., *Osumi, N.
  • 雑誌名: Development 131 ページ: 787-796
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo. (2004)
  • 著者名/発表者名: Hiramatsu, H., *Yasugi, S.
  • 雑誌名: Int. J. Dev. Biol. 48 ページ: 1141-1148
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] their identification and regulation. (2004)
  • 著者名/発表者名: Tabata, T., Takei, Y.Morphogens
  • 雑誌名: Development 131 (4) ページ: 703-712
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Expression patterns of Xenopus FGF receptor-like 1 /nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8. (2004)
  • 著者名/発表者名: Hayashi, S., Itoh, M., Taira, S., Agata, K., *Taira, M.
  • 雑誌名: Dev. Dyn. 230 ページ: 700-707
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox 11 /tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. (2004)
  • 著者名/発表者名: Kojima, T., Tsuji, T., Saigo, K.
  • 雑誌名: Dev. Biol. 279 ページ: 434-445
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Molecular dissection of the alpha-dystroglycanand integrin-binding sites within the globular domain of human laminin-10. (2004)
  • 著者名/発表者名: Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A.C., Ervasti, J.M., *Sekiguchi, K.
  • 雑誌名: J. Biol. Chem. 279 ページ: 10946-10954
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. (2004)
  • 著者名/発表者名: Usui, M., *Noda, M.
  • 雑誌名: Proc. Natl. Acad. Sci. U SA 101 ページ: 6653-6658
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The ACR4 receptor-like kinase is required for surface formation of epidermis-related tissues in Arabidopsis thaliana. (2004)
  • 著者名/発表者名: Watanabe, M., Tanaka, H., Machida, C., Watanabe, D, *Machida, Y
  • 雑誌名: Plant J. 39 ページ: 298-308
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. (2004)
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  • 雑誌名: Development 131 ページ: 5527-5537
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Tracing of Xenopus tropicalis germ plasm and presumptive primordial germ cells with the Xenopus tropicalis DAZ-like gene (2004)
  • 著者名/発表者名: Sekizaki, H.
  • 雑誌名: Developmental Dynamics 229 ページ: 367-372
• [雑誌論文] Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells (2004)
  • 著者名/発表者名: Yoshida-Koide, U.
  • 雑誌名: B.B.R.C. 313 ページ: 475-481
• [雑誌論文] Xenopus tropicalis nodal-related gene3 regulates BMP signaling : an essential role for the pro-region (2004)
  • 著者名/発表者名: Haramoto, Y.
  • 雑誌名: Developmental Biology 265 ページ: 155-168
• [雑誌論文] Inhibition of the canonical Wnt signaling pathway in cytoplasm : a novel property of the carboxyl terminal domains of two Xenopus ELL genes (2004)
  • 著者名/発表者名: Sakurai, K.
  • 雑誌名: Zoological Science 21 ページ: 407-416
• [雑誌論文] Sall, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling bylocalizing to heterochromatin (2004)
  • 著者名/発表者名: Sato, A.
  • 雑誌名: B.B.R.C. 319 ページ: 103-113
• [雑誌論文] Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice (2004)
  • 著者名/発表者名: Takasato, M.
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• [雑誌論文] Xantivin suppresses the activity of EGF-CFC genes to regulate nodal signaling (2004)
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  • 雑誌名: Int.J.Dev.Biol. 48 ページ: 275-283
• [雑誌論文] Activin-like signaling activates Notch signaling during mesodermal induction (2004)
  • 著者名/発表者名: Abe, T.
  • 雑誌名: Int.J.Dev.Biol. 48 ページ: 327-332
• [雑誌論文] Xldax, an inhibitor of the canonical Wnt pathway is required for anterior neural structure formation in Xenopus (2004)
  • 著者名/発表者名: Michiue, T.
  • 雑誌名: Developmental Dynamic 230 ページ: 79-90
• [雑誌論文] The role of Xenopus frizzled-8 in pronephric development (2004)
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  • 雑誌名: B.B.R.C. 321 ページ: 487-494
• [雑誌論文] XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/_-catenin signalling (2004)
  • 著者名/発表者名: Yukita, A.
  • 雑誌名: Genes to Cell 9 ページ: 723-736
• [雑誌論文] XSIP1 is essential for early neural gene expression and neural differential by suppression of BMP signaling (2004)
  • 著者名/発表者名: Nitta, R.K.
  • 雑誌名: Developmental Biology 275 ページ: 258-267
• [雑誌論文] Role of TSC-22 during early embyogenesis in Xenopus laevis (2004)
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  • 雑誌名: Develop.Growth Differ. 46 ページ: 535-544
• [雑誌論文] Identification and characterization of Xenopus OMP25 (2004)
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  • 雑誌名: Develop.Growth Differ. 46 ページ: 405-412
• [雑誌論文] Induction of tooth and eye by transplantation of activin A-treated, undifferentiated presumptive ectodermal Xenopus cells into the abdomen (2004)
  • 著者名/発表者名: Myoishi, Y.
  • 雑誌名: Int.J.Dev.Biol. 48 ページ: 1105-1112
• [雑誌論文] Molecular analysis of the determination of developmental fate in the small Intestinal epithelium in the chicken embryo (2004)
  • 著者名/発表者名: Hiramatsu, H.
  • 雑誌名: Int.J.Dev.Biol. 48 ページ: 1141-1148
• [雑誌論文] Expression patterns of Xenopus FGF receptor-like 1/nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8 (2004)
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  • 雑誌名: Dev.Dyn. 230 ページ: 700-707
• [雑誌論文] Morphological and functional recovery of the planarian photosensing system during head regeneration (2004)
  • 著者名/発表者名: Inoue, T.
  • 雑誌名: Zool.Sci. 21 ページ: 275-283
• [雑誌論文] Detection of apoptosis during planarian regeneration by TUNEL assay and expression of apoptosis-related genes (2004)
  • 著者名/発表者名: Hwang, J.S.
  • 雑誌名: Gene 333 ページ: 15-25
• [雑誌論文] Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system (2004)
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  • 雑誌名: Developmental Brain Research 153 ページ: 143-150
• [雑誌論文] Chick Dach1 interacts with Smad1 and mSin3A to control AER formation and limb development along the proximal-distal axis (2004)
  • 著者名/発表者名: Kida, Y.
  • 雑誌名: Development 131 ページ: 4179-4187
• [雑誌論文] Vertebrate Crossveinless 2 is secreted and acts as a modulator of the BMP signaling cascade (2004)
  • 著者名/発表者名: Kamimura, M.
  • 雑誌名: Developmental Dynamics 230 ページ: 434-445
• [雑誌論文] Tbx genes specify posterior digit identity through Shh and BMP signaling (2004)
  • 著者名/発表者名: Suzuki, T.
  • 雑誌名: Developmental Cell 6 ページ: 43-53
• [雑誌論文] Morphpgens, their identification and regulation. (2004)
  • 著者名/発表者名: Tabata, T.
  • 雑誌名: Development 131 ページ: 703-712
• [雑誌論文] Wnt/β-Catenin and Estrogen Signaling Converge in Vivo. (2004)
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  • 雑誌名: J.Biol.Chem. 279 ページ: 40255-40258
• [雑誌論文] Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. (2003)
  • 著者名/発表者名: Takeushi, J.K., Ohgi, M., Koshiba-Takeuchi, K., Shiratori, H., Sasaki, I., Ogura, K., Saijoh, Y., Ogura, T.
  • 雑誌名: Development 130 ページ: 5953-5964
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs. (2003)
  • 著者名/発表者名: Mineta, K., Nakagawa, M., cebria, F., Ikeo, K., Agata, K., Gojobori, T.
  • 雑誌名: Proc.Natl.Acad.Sci.USA 100 ページ: 7666-7671
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C.elegans. (2003)
  • 著者名/発表者名: Zhao, S., Sawa, H., Herman, M.A.
  • 雑誌名: Dev.Biol. 256 ページ: 276-289
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] CD151 regulates epithelial cell-cell adhesion through PKC-and Cdc42-dependent actin cytoskeletal reorganization. (2003)
  • 著者名/発表者名: Shigeta, M., Sanzen, N., Gu, J., Haswgawa, T., Sekiguchi, K.
  • 雑誌名: J.Cell Biol. 163 ページ: 165-176
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cell-autonomous involvement of Mab2111 is essential for lens placode development. (2003)
  • 著者名/発表者名: Yamada, R., Mizutani-Koseki, Y., Hasegawa, T., Osumi, N., Koseki, H., Takahashi, N.
  • 雑誌名: Development 130 ページ: 1759-1770
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Feedback loops comprising Dll1,Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. (2003)
  • 著者名/発表者名: Takahashi, Y., Inoue, T., Gossler, A., Saga, Y.
  • 雑誌名: Development 130 ページ: 4259-4268
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. (2003)
  • 著者名/発表者名: Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I., Furukawa, T.
  • 雑誌名: Nature Neurosci. 6 ページ: 1255-1263
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. (2003)
  • 著者名/発表者名: Sasamura, T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H., Ito, M., Kitagawa, M., Harigaya, K., Spana, E., Bilder, D., Perrimon, N., Matsuno, K.
  • 雑誌名: Development 130 ページ: 4785-4795
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. (2003)
  • 著者名/発表者名: Takeuchi, J.K., Ohgi, M., Koshiba-Takeuchi, K., Shiratori, H., Sasaki, I., Ogura, K., Saijoh, Y., *Ogura, T.
  • 雑誌名: Development 130 ページ: 5953-5964
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs. (2003)
  • 著者名/発表者名: Mineta, K., Nakagawa, M., cebria, R, Ikeo, K., Agata.K.., *Gojobori, T.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 100 ページ: 7666-7671
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans. (2003)
  • 著者名/発表者名: Zhao, S., Sawa, H., *Herman, M.A.
  • 雑誌名: Dev. Biol. 256 ページ: 276-289
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] CD151 regulates epithelial cell-cell adhesion through PKC-and Cdc42-dependent actin cytoskeletal reorganization. (2003)
  • 著者名/発表者名: Shigeta, M., Sanzen, N., Gu, J., Hasegawa, T., *Sekiguchi, K.
  • 雑誌名: J. Cell Biol. 163 ページ: 165-176
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Cell-autonomous involvement of Mab2111 is essential for lens placode development. (2003)
  • 著者名/発表者名: Yamada, R., Mizutani-Koseki, Y., Hasegawa, T., Osumi, N., Koseki, H., *Takahashi, N.
  • 雑誌名: Development 130 ページ: 1759-1770
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Feedback loops comprising Dill, D113 and Mesp2, and differential involvement of Psenl are essential for rostrocaudal patterning of somites. (2003)
  • 著者名/発表者名: Takahashi, Y., Inoue, T., Gossler, A., *Saga, Y.
  • 雑誌名: Development 130 ページ: 4259-4268
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. (2003)
  • 著者名/発表者名: Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I, *Furukawa, T.
  • 雑誌名: Nature Neurosci. 6 ページ: 1255-1263
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] neurotic, a novel maternal neurogenic gene, encodes an 0- fucosyltransferase that is essential for Notch-Delta interactions. (2003)
  • 著者名/発表者名: Sasamura, T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H.O., Ito, M., Kitagawa, M., Harigaya, K., Spana, E., Bilder, D., Perrimon, N., *Matsuno, K.
  • 雑誌名: Development 130 ページ: 4785-4795
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach. (2002)
  • 著者名/発表者名: Takeda, J., Tabata, H., Fukuda, K.Yasugi, S.
  • 雑誌名: Dev.Growth＆Differ. 44 ページ: 501-508
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  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The pre-gut endoderm of chick embryo is reginolized by 1.5 days of development. (2002)
  • 著者名/発表者名: Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., Yasugi, S.
  • 雑誌名: Dev.Dyn. 223 ページ: 33-47
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro. (2002)
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• [雑誌論文] Transition of Hox expression during limb cartilage development. (2002)
  • 著者名/発表者名: Suzuki, M., Kuroiwa, A.
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  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach. (2002)
  • 著者名/発表者名: Takeda, J., Tabata, H., Fukuda, K., *Yasugi, S.
  • 雑誌名: Dev. Growth ＆ Differ. 44 ページ: 501-508
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  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The pre-gut endoderm of chick embryo is reginolized by 1.5 days of development. (2002)
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  • 雑誌名: Dev. Dyn. 233 ページ: 33-47
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro. (2002)
  • 著者名/発表者名: Furue, M., Myoishi, Y., Fukui, Y., Ariizumi, T., Okamoto, T., *Asashima, M.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 99(24) ページ: 1574-1579
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Transition of Hox expression during limb cartilage development. (2002)
  • 著者名/発表者名: Suzuki, M., *Kuroiwa, A.
  • 雑誌名: Mech. Dev. 118 ページ: 241-245
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Genetics of morphogen gradients (2001)
  • 著者名/発表者名: Tabata, T.
  • 雑誌名: Nature 2 ページ: 620-630
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Dorsal and ventral positional cues required for the onset of planarian regeneration May reside in differentiated cells. (2001)
  • 著者名/発表者名: Kato, K., Orii, H., Watanabe, K., Agata, K.
  • 雑誌名: Dev.Biol. 239 ページ: 241-256
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2. (2001)
  • 著者名/発表者名: Meno, C., Takeushi, J., Sakuma, R., Koshiba-Takeuchi, K., Ohishi, S., Saijoh, Y., Miyazaki, J., Dijike, P., Ogura, T., Hamada, H.
  • 雑誌名: Dev.Cell. 1 ページ: 127-138
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] HoxA and HoxB cluster genes subdivide the digestive tract in to morphological domains during chick development. (2001)
  • 著者名/発表者名: Sakiyama, J., Yokouchi, Y., Kuroiwa, A.
  • 雑誌名: Mech.Dev. 101 ページ: 233-236
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Translational repression determines a neuronal potential in Drosophila asymmetric cell division. (2001)
  • 著者名/発表者名: Okabe, M., Imai, T., Kurusu, M., Hiromi, Y., Okano, H.
  • 雑誌名: Nature 411 ページ: 94-98
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. (2001)
  • 著者名/発表者名: Takizawa, T., Nakashima, K., Namihira, M., Ochiai, W., Uemaura, A., Yanagisawa, M., Fujita, N., Nakao, M., Taga, T.
  • 雑誌名: Dev.Cell 1 ページ: 749-758
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. (2001)
  • 著者名/発表者名: Nishinakamura, R., Matsumoto, Y., Nakao, K., Nakamura, K., Sato, A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Scully, S., Lacey, D.L., Katsuki, M., Asashima, M., Yokota, T.
  • 雑誌名: Development 128 ページ: 3105-3115
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Embryonic and larval development of the Drosophila mushroom bodies : concentric layer subdivisions and the role of Fasciclin II. (2001)
  • 著者名/発表者名: Kurusu, M., Awasaki, T., Masuda-Nakagawa, L.M., Kawauchi, H., Ito, K., Furukubo-Tokunaga, K.
  • 雑誌名: Development 129 ページ: 40-419
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates lamina formation, establishment of venation and repression of meristem-related homeobox genes in the leaf. (2001)
  • 著者名/発表者名: Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., Machida, Y.
  • 雑誌名: Development 128 ページ: 1771-1783
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Liver organogenesis promoted by endothelial cells prior to vascular function. (2001)
  • 著者名/発表者名: Matsumoto, K., Yoshitomi, H., Rossant, J., Zaret, K.
  • 雑誌名: Science 294 ページ: 559-563
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Genetics of morphogen gradients. (2001)
  • 著者名/発表者名: Tabata, T.
  • 雑誌名: Nature Reviews Genetics 2 ページ: 620-630
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Dorsal and ventral positional cues required for the onset of planarian regeneration May reside in differentiated cells. (2001)
  • 著者名/発表者名: Kato, K., Orii, H., Watanabe, K., *Agata, K.
  • 雑誌名: Dev. Biol. 239 ページ: 241-256
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor (2001)
  • 著者名/発表者名: Meno, C., Takeuchi, J., Sakuma, R., Koshiba-Takeuchi, K., Ohishi, S., Saijoh, Y., Miyazaki, J., Dijike, P., Ogura, T., *Hamada, H.
  • 雑誌名: Lefty2. Dev. Cell 1 ページ: 127-138
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] HoxA and HoxB cluster genes subdivide the digestive tract into morphological domains during chick development. (2001)
  • 著者名/発表者名: Sakiyama, J., Yokouchi, Y., *Kuroiwa, A.
  • 雑誌名: Mech. Dev. 101 ページ: 233-236
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Translational repression determines a neuronal potential in Drosophila asymmetric cell division (2001)
  • 著者名/発表者名: Okabe, M., Imai, T., Kurusu, M., Hiromi, Y., *Okano, H.
  • 雑誌名: Nature 411 ページ: 94-98
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. (2001)
  • 著者名/発表者名: Takizawa, T., Nakashima, K., Namihira, M., Ochiai, W., Uemaura, A., Yanagisawa, M., Fujita, N., Nakao, M., *Taga, T.
  • 雑誌名: Dev. Cell 1 ページ: 749-758
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. (2001)
  • 著者名/発表者名: Nithinakamura, R・Matsumoto, Y., Nakao, K., Nakamura, K., Sato, A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Scully, S., Lacey, D.L., Katsuki, M., Asashima, M., Yokota, T.
  • 雑誌名: Development 128 ページ: 3105-3115
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Embryonic and larval development of the Drosophila mushroom bodies : concentric layer subdivisions and the role of Fasciclin II. (2001)
  • 著者名/発表者名: Kurusu, M., Awasaki, T., Masuda-Nakagawa, L.M., Kawauchi, H., Ito, K., *Furukobo-Tokunaga, K.
  • 雑誌名: Development 129 ページ: 40-419
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates lamina formation, establishment of venation and repression of meristem-related homeobox genes in the leaf. (2001)
  • 著者名/発表者名: Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., *Machida, Y.
  • 雑誌名: Development 128 ページ: 1771-1783
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Liver organogenesis promoted by endothelial cells prior to vascular function. (2001)
  • 著者名/発表者名: Matsumoto, K., Yoshitomi, H., Rossant, J., *Zaret, K.
  • 雑誌名: Science 294 ページ: 559-563
  • 説明: 「研究成果報告書概要(欧文)」より
• [図書] The vertebrate organizer (2004)
  • 著者名/発表者名: Asashima, M.
  • 総ページ数: 320
  • 出版者: Springer
• [産業財産権] 細胞分化誘導法 (2005)
  • 発明者名: 中山泰秀, 黄海瑛, 安藤譲二, 山下潤, 伊藤裕, 神田圭一, 岡本吉弘, 根元泰
  • 権利者名: 国立循環器病センター総長, 株式会社ブリジストン
  • 出願年月日: 2005-03-10
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] ES細胞の分化誘導方法 (2005)
  • 発明者名: 昭苑, 白木伸明, 吉田 哲, 後藤秀夫, 粂 和彦
  • 権利者名: 国立大学法人熊本大学
  • 産業財産権番号: 2005-150800
  • 出願年月日: 2005-05-24
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] DNAとcDNAクローンの対応方法及び対応表を記録した記録媒体, 並びにcDNA検索サービス提供方法及びcDNA検索サービス提供サーバ (2005)
  • 発明者名: 仲嶋一範, 前田卓哉, 味岡逸樹
  • 権利者名: 学校法人慶応義塾
  • 産業財産権番号: 2005-227223
  • 出願年月日: 2005-08-04
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] 動脈内皮細胞の判別方法 (2004)
  • 発明者名: 中山泰秀, 黄長澤 丘司, 山下潤, 小林 貴美, 荒 敏昭
  • 権利者名: 国立大学法人京都大学
  • 出願年月日: 2004-12-28
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] 霊長類動物胚性幹細胞から発生初期血管内皮細胞の製造方法及びその細胞の使用 (2004)
  • 発明者名: 中尾一和, 伊藤裕, 山下 潤, 曽根正勝, 山原研一, 近藤靖, 鈴木 豊
  • 権利者名: 田辺製薬株式会社
  • 出願年月日: 2004-06-22
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] 組織特異的に細胞増殖を制御する遺伝子 (2003)
  • 発明者名: 高橋直樹, 山田竜一, 古関明彦, 古関庸子, 長谷川孝徳, 大隈典子
  • 権利者名: 財団法人奈良先端科学技術大学院大学支援財団
  • 産業財産権番号: 2003-143311
  • 出願年月日: 2003-05-21
  • 取得年月日: 2004-12-09
  • 説明: 「研究成果報告書概要(和文)」より
• [産業財産権] cDNA encoding a BMP type II receptor (2001)
  • 発明者名: J.S.Rosenbaum, T.Nohno
  • 権利者名: United States Patent
  • 出願年月日: 2001-10-23
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Shimizu, Y.: "Kinetics of v-src-induced epithelial-mesenchymal transition in developing glandular stomach."Oncogene. 22. 884-893 (2003)
• [文献書誌] Saito, K.: "Morphological asymmetry in dividing retinal progenitor cells."Dev.Growth Differ.. 45. 219-229 (2003)
• [文献書誌] Shin, M.: "Expression of DDSG1, a novel gene encoding a putative DNA-binding protein in the embryonic chicken nervous system."Gene Expression Pattern. 3. 431-436 (2003)
• [文献書誌] Fukuda, K.: "Down-regulation of endodermal Shh is required for gland formation in chicken stomach."Mech.Dev.. 120. 801-809 (2003)
• [文献書誌] Watanuki, K.: "Analysis of transcription regulatory regions of embryonic chicken pepsinogen (ECPg) gene."Dev.Dyn.. 228. 51-58 (2003)
• [文献書誌] Sato, A.: "Zinc finger protein Sall2 is not essential for embryonic and kidney development."Mol.Cell.Biol.. 23. 62-69 (2003)
• [文献書誌] Yabe, S.: "FRL-1, a member of the EGFCFC family, is essential for neural differentiation in Xenopus early development"Development. 130. 2071-2081 (2003)
• [文献書誌] Yokota, C.: "A novel role for a nodal-related protein ; Xnr3 regulates convergent extension movements via the FGF receptor"Development. 130. 2199-2212 (2003)
• [文献書誌] Fukui, A.: "Immunocytochemical study of activin type IB receptor (XALK4) in Xenopus oocytes"Dev.Growth Differ.. 45. 113-119 (2003)
• [文献書誌] Sogame, A.: "Screening for novel pancreatic genes from in vitro-induced pancreas in Xenopus"Dev.Growth Differ.. 45. 143-152 (2003)
• [文献書誌] Hino, S.: "Casein kinase I enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of β-catenin"J.Biol.Chem.. 278. 14066-14073 (2003)
• [文献書誌] Kaneko, T.: "The isolation and characterization of XC3H-3b : a CCCH zinc-finger protein required for pronephros development"Biochem.Biophys.Res.Commun.. 308. 566-572 (2003)
• [文献書誌] Kyuno, J.-I.: "Identification and characterization of Xenopus NDRG1"Biochem.Biophys.Res.Commun.. 309. 52-57 (2003)
• [文献書誌] Okabayashi, K.: "Tissue generation from amphibian animal caps"Cur.Opinion Genet.Dev.. 13. 1-6 (2003)
• [文献書誌] Tanaka, M.: "Proliferation and differentiation of Xenopus A6 cells under hypergravity as revealed by time-lapse imaging, In Vitro Cell."Dev.Biol.Animal. 39. 71-79 (2003)
• [文献書誌] Asashima, M.: "Current state of and outlook for organogenesis from undifferentiated cells"Cornea. 22. 2-12 (2003)
• [文献書誌] Emura, T.: "Experimental study of the embryogenesis of gastrointestinal duplication and enteric cyst"Pediatr.Surg.Int.. 19. 147-151 (2003)
• [文献書誌] Ariizumi, T.: "Amphibian in vitro heart induction : a simple and reliable model for the study of vertebrate cardiac development"Int.J.Dev.Biol.. 47. 405-410 (2003)
• [文献書誌] Yoshida-Koide, U.: "Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells"Biochem.Biophys.Res.Commun.. 313. 475-481 (2003)
• [文献書誌] Sedohara, A.: "In vitro induction and transplantation of eye during early Xeonopus development"Dev.Growth Differ.. 45. 463-471 (2003)
• [文献書誌] Fukui, Y.: "Longterm culture of Xenopus presumptive ectoderm in a nutrient-supplemented culture medium"Dev.Growth Differ.. 45. 499-506 (2003)
• [文献書誌] Hashimoto-Torii, K.: "Differential activities of sonic hedgehog mediated by Gli transcription factors define distinct neuroral subtypes in the dorsal thalamus"Mech.Dev.. 120. 1097-1111 (2003)
• [文献書誌] Sakiyama, J.: "Tbx4-Fgf10 system controls lung bud formation during chicken embryonic development."Development. 130. 1225-1234 (2003)
• [文献書誌] Suzuki, M.: "Hox proteins functionally cooperate with the GC box-binding protein system through distinct domains."J.Biol.Chem.. 278. 30148-30156 (2003)
• [文献書誌] Yamamoto, M.: "Hoxa-11 and Hoxa-13 are involved in repression of MyoD during limb muscle development."Dev.Growth Differ.. 45. 485-498 (2003)
• [文献書誌] Suzuki, T.: "Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling."Dev.Cell. 6. 43-53 (2004)
• [文献書誌] Takeuchi, J.K.: "Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis."Development. 130. 5953-5964 (2003)
• [文献書誌] Takeuchi, J.K.: "Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade."Development. 130. 2729-2739 (2003)
• [文献書誌] Takei, Y.: "Three Drosophila EXT genes shape morphogen gradients through synthesis of Heparan Sulfate Proteoglycans."Development. 131. 73-82 (2004)
• [文献書誌] Agata, K.: "Regeneration and gene regulation in planarians"Cur.Opinion Genet.Dev.. 13. 492-496 (2003)
• [文献書誌] Mineta, K.: "Origin and evolutionary process of the CNS elucidated by the comparative genomic analysis of planarian ESTs."Proc.Nat.Acad.Sci.USA. 100. 7666-7671 (2003)
• [文献書誌] Nakazawa, M.: "Search for the evolutionary origin of a brain ; Planarian brain characterized by microarray."Mol.Biol.Evol.. 20. 784-791 (2003)
• [文献書誌] Koinuma, S.: "The expression of planarian brain factor homologs, DjFoxG and DjFoxD."Gene Expr. Pattern. 3. 21-27 (2003)
• [文献書誌] Agata, K.: "Intercalary regeneration in planarian."Dev.Dyn.. 226. 308-316 (2003)
• [文献書誌] Saito, Y.: "Medio-Lateral Intercalation in Planarians Revealed by Grafting Experiments."Dev.Dyn.. 226. 334-340 (2003)
• [文献書誌] 浅島 誠: "動物の体作り"クバプロ. 207 (2003)
• [文献書誌] Fukuda, K.: "Versatile roles for sonic hedgehog in gut development"J. Gastroentevol. 37. 239-246 (2002)
• [文献書誌] Shimizu, Y.: "Kinetcs of v-sarc-induced epithelial-mesenchymal transition in developing glandular stomach"Oncogene. 22. 884-893 (2003)
• [文献書誌] Takeda, J.: "Involvement of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation if chicken glandular stomach"Dev. Growth Differ.. 44. 501-508 (2002)
• [文献書誌] Furue, M.: "Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro"Proc. Nat. Acad. Sci., USA. 99. 15474-15479 (2002)
• [文献書誌] Onuma, Y.: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"Proc. Nat. Acad. Sci., USA. 99. 2020-2025 (2002)
• [文献書誌] Kuroda, H.: "Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus"Dev. Biol.. 244. 267-277 (2002)
• [文献書誌] Kobayashi, M.: "Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway"J. Biol. Chem. 277. 5816-5822 (2002)
• [文献書誌] Hagata, T.: "Overexpression of the secreted factor Mig30 expressed in the Spemann organizer impairs morpholgenetic movements during Xenopus gastrulation"Mech. Dev.. 112. 37-51 (2002)
• [文献書誌] Hayashi, T.: "Regulated lens regeneration from isolated pigmented epithelial cells of newt iris in culture in response to FGF2/4/"Differentiation. 70. 101-108 (2002)
• [文献書誌] Koshida, S.: "Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish"Dev. Biol.. 244. 9-20 (2002)
• [文献書誌] Suzuki, M.: "Transition of Hox expression during limb cartilage development"Mech. Dev.. 118. 241-245 (2002)
• [文献書誌] Ogura, T.: "In vivo electroporation : new frontier for gene delivery and embryology"Differentiation. 70. 163-171 (2002)
• [文献書誌] Sakuma, R.: "Inhibition of Nodal signaling by lefty mediated through interaction with common receptors and efficient diffusion"Genes Cells. 7. 401-412 (2002)
• [文献書誌] Cebria, F.: "FGFR-related gene nou-darake restricts brain tissues to the head region of planarians"Nature. 419. 620-624 (2002)
• [文献書誌] Ogawa, K.: "Induction of a noggin-like gene by ectopic D-V interaction during planarian regeneration"Dev. Biol.. 250. 59-70 (2002)
• [文献書誌] Cebria, F.: "Dissecting planarian CNS regeneration by the expression of neural-specific genes"Dev. Growth. Differ.. 44. 135-146 (2002)
• [文献書誌] Cebria, F.: "The expression of neural-specific genes reveals the structural and molecular complexity of the planarian central nervous system"Mech. Dev.. 116. 199-204 (2002)
• [文献書誌] Asami, M.: "Cultivation and characterization of planarian neuronal cells isolated by fluorescence activated cell sorting (FACS)"Zool. Sci.. 19. 1257-1265 (2002)
• [文献書誌] 八杉 貞雄: "よくわかる基礎生命科学"サイエンス社. 144 (2002)
• [文献書誌] Kato, K.: "Dorsal and ventral positional cues required for the onset of planarian regeneration may reside in differentiated cells"Developmental Biology. 233. 109-121 (2001)
• [文献書誌] Kishida, M.: "Synergistic activation of the want signaling pathway by Dvl and casein kinase I epsilon"Journal of Biological Chemistry. 276. 33147-33155 (2001)
• [文献書誌] Yamamoto, H.: "Inhibition of the wnt signaling pathway by the PR61 subnit of protein phosphatase 2A"Journal of Biological Chemistry. 276. 26875-26882 (2001)
• [文献書誌] Furue, M.: "Activin A induces expression of rat sel-1lmRNA,a negative regulator of notch signaling,in rat salivary gland-derived epithelial cells"Biochem.Biophys.Res.Commun.. 282. 745-749 (2001)
• [文献書誌] Ichigi, J.: "Dome formation and tubule morphogenesis by xenopus kidney A6 cells cultures exposed to microgravity stimulated with 3D-clinostat and to hyporgravity"In Vitro Cell.Dev.Biol.Anin.. 37. 31-44 (2001)
• [文献書誌] Arizumi, T.: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"Int.J.Dev.Biol.. 45. 273-279 (2001)
• [文献書誌] Ogura, K.: "Cloning and chromocome mapping of human and chicken Iroguois(IRX)gene"Cytogenet.Cell Genet.. 92. 320-325 (2001)
• [文献書誌] Kuramochi-Miyagawa, S.: "Two mouse piwi-related genes:miwi and mili"Mech.Dev.. 108. 121-133 (2001)
• [文献書誌] Bruneau, S.: "The mouse hoxd13(spdh)mutation,a polyalanine expansion simlarto human type II synpolydactyly(spd),disrupts the function but not the expression of other hoxd genes"Developmental Biology. 237. 345-353 (2001)
• [文献書誌] Sakaguchi, T.: "A novelsox gene,226 D7,acts downstream of Nocial sigualing to specify endoderm preccusors in zevrafish"Mech.Dev.. 107. 25-38 (2001)
• [文献書誌] Hayashi, T.: "Highly efficient trans fection system for functional gene analysis in adult amphibian leus regeneration"Dev.Growth Differ.. 43. 361-370 (2001)
• [文献書誌] Sakaguchi, T.: "Expression of zebrafish btg-b,and anti-proliferative co factor,during early embryogenesis"Mech.Dev.. 104. 113-115 (2001)
• [文献書誌] Funakoshi, Y.: "mtv shapes the activity grachent of the DPP morphogen through regulation of thick veins"Development. 128. 67-74 (2001)
• [文献書誌] Tabata, T.: "Genetics of morphogen gradient"Nature Rev.Genetics. 2. 620-630 (2001)
• [文献書誌] Matsushita, S.: "Pre-gut endoderm of chick embryo is regionalized by 1.5 days of development"Dev.Dyn.. 223. 33-47 (2002)
• [文献書誌] Yasugi, E.: "Disruption of mitochondria is an early event during dolichyl monophosphate-induced apoptosis in U937 cells"Zool.Sci.. 19. 7-13 (2002)
• [文献書誌] 西賀秀俊: "たった一つの卵から"東京化学同人. 207 (2001)