環境温変化に伴う体温調節系と心循環器系の相互相関

• 研究課題/領域番号: 13670061
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 環境生理学(含体力医学・栄養生理学)
• 研究機関: 名古屋大学
• 研究代表者: 岩瀬 敏 名古屋大学, 環境医学研究所, 助教授 (90184879)
• 研究分担者: 神谷 厚範 名古屋大学, 環境医学研究所, 助手 (30324370)
• 研究期間 (年度): 2001 – 2003
• 研究課題ステータス: 完了 (2003年度)
• 配分額: 4,000千円 (直接経費: 4,000千円); 2003年度: 900千円 (直接経費: 900千円); 2002年度: 1,000千円 (直接経費: 1,000千円); 2001年度: 2,100千円 (直接経費: 2,100千円)
• キーワード: 筋交感神経活動MSNA / 皮膚交感神経活動SSNA / 体温調節能thermoregulatory function / 相互相関cross-correlation / マイクロニューログラフィティーmicroneurography / 心循環器系cardiovascular function / 放熱heat loss / 末梢血管収縮能vasoconstrictive function / スペクトル解析spectral analysis / マイクロニューログラフィーmicroneurograhy / 皮膚交感神経活動 / 体温調節 / 発汗 / 皮膚血管収縮 / 筋交感神経活動 / 血圧調節 / 鼓膜温 / 圧受容器反射

研究概要

筋交感神経活動MSNAと皮膚交感神経活動SSNAの共通性・相違性を明確化するために,環境温の変化を外乱とした体温調節機構応答を解析した.自律神経の変動計測にはmicroneurographyによりMSNAとSSNAを同時測定した.従来の研究で明らかとなった体温調節能の優劣(環境温変化に対する核心温変化の一定性)は交感神経反応が大きくMSNAとSSNAが共通性を持つことが重要であり,互いにたfeedbackあるいはfeedfoward系の一部として相補的に連携する,つまり体温調節は閉ループ制御だけでは機能せず,開ループ制御も兼備する必要がある.本研究ではこの機能を安静時におけるMSNAとSSNAとの相互相関のタイムラグの対称性を優劣の指標とした.8名の被験者に人工気候室内で両側の脛骨神経からMSNAとSSNAを同時記録し,室温25℃,15℃,40℃の各環境で20分間滞在した際の相互相関と最大エントロピー法による周波数を解析した.体温調節能の優劣によらず各環境下において,心拍周期,呼吸周期,10秒(Mayerリズム),20秒周期のリズムに同期するスペクトルピーク(SP)が認められた.体温調節能優良者は心拍周期成分以外ではMSNAとSSNAに共通性を有していた.寒冷時にはMSNA, SSNAともに亢進し,Mayerリズムと同期した.暑熱時では心拍・呼吸由来周波数でSPの増大が認められた.暑熱下においてはMayerリズムが著現したが,循環血漿量減少により心循環器系が支配的になるためと推測された.体温調節能不良者は,暑熱下の各SSNAスペクトル帯域での分散が大きく,心循環器系成分に同期するSSNAのSPは体温調節能の優劣で異なっていた.心拍および20秒周期に同期するMSNAのSPは体温調節能の優劣により差異を生じ,SSNAによる末梢血管調節性放熱に依存することが示唆された.

研究成果

• [文献書誌] IWASE S, CUI J, WALLIN B G, et al.: "Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans."Neuroscience Letters. 127. 37-40 (2002)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Okagawa T, Sugenoya J, Iwase S et al.: "Occurance of the spinal reflex due to skin pressure in sudomotor and ocutaneous vasoconstrictor nerve system of humans."Autonomic Nueroscience : Basic and Clinical. 105. 62-70 (2003)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kamiya K, Michikami D, Fu Q, Iwase S, et al.: "Pathophysiology of orthostatic hypotension after bed rest : Paradoxical sympathetic withdrawal"American Journal of Physiology Heart & Circulatory Physiology. 285. H1158-H1167 (2003)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Michikami D, Kamiya A, Fu Q, Iwase S, et al.: "Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans."Journal of Applied Physiology. 96. 107-114 (2004)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] Kondo M, Iwase S, Mano T, Kuzuhara S: "Direct measurement of human sympathetic nerve conduction velocity."Muscle and Nerve. 29. 128-133 (2004)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] 岩瀬敏一: "電場の医療応用"フジ・テクノシステム. 55/1005 (2004)
  • 説明: 「研究成果報告書概要(和文)」より
• [文献書誌] IWASE Satoshi, MANO Tadaski, KAMIYA Atsunori, NIIMI Yuki, FU Qi, SUZUMURA Akio: "Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans."Autonomic Neuroscience : Basic and Clinical. 95. 141-145 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] FU Qi, IWASE Satoshi, NIIMI Yuki, KAMIYA Atsunori, MICHIKAMI Daisaku, MANO Tadaaki, SUZUMURA Akio: "Age-related changes in vasomotor reflex control of calf venous capacitance responses to lower body negative pressure in humans."Japanese Journal of Physiology. 52. 69-76 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] FU Qi, IWASE Satoshi, NIIMI Yuki, KAMIYA Atsunori, MICHIKAMI Daisaku, MANO Tadaaki, SUZUMURA Akio: "Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans."Japanese Journal of Physiology. 52. 77-84 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] IWASE Satoshi, CUI Jian, WALLIN B Gunnar, KAMIYA Atsunori, MANO Tadaaki: "Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans."Neuroscience Letters. 327. 37-40 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] MICHIKAMI Daisaku, KAMIYA Atsunori, FU Qi, NIIMI Yuki, IWASE Satoshi, MANO Tadaaki, SUZUMURA Akio: "Forearm elevation augments sympathetic activation during handgrip exercise in humans."Clin Sci (Lond). 103. 295-301 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] 6.FU Qi, LEVINE Benjamin D, PAWELCZYK James A, ERTL Andrew C, DIEDRICH Andre, COX James F, ZUCKERMAN Julie H, RAY Chester A, SMITH Michael L, IWASE Satoshi, SAITO Mitsuru, SUGIYAMA Yoshiki, TADAAKI Mano, ZHANG Rong, IWASAKI Kenichi, LANE Lynda D, BUCKEY Jay C Jr., COOKE William H, ROBERTSON Rose Mane, BAISCH Friedheim J, BLOMQVIST C Gunnar, ECKBERG Dwain L, ROBERTSON David, BLAGGIONI Italo: "Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli before, during and after spaceflight."Journal of Physiology. 544. 653-664 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Fu Q, Vinogradova OL, Kamiya A, Michikami D, Cui J, Niimi Y, Iwase S, Mano T.: "Effects of simulated microgravity on leg venous compliance in orthostatic intolerance."Aviakosm Ekolog Med.. 46-50 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Vinogradova OL, Stoida IuM, Mano T, Iwase S.: "Effects of gravitational unloading on blood supply of working muscles"Aviakosm Ekolog Med.. 36. 39-46 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] MICHIKAMI Daisaku, KAMIYA Atsunori, FU Qi, NIIMI Yuki, IWASE Satoshi, MANO Tadaaki, SUZUMURA Akio: "Effect of simulated microgravity exposure on thermoregulatory control of sweating."Environmental Medicine. 45(2). 58-61 (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] IWASE Satoshi, CUI Jian, WALLIN Gunnar G, MANO Tadaaki: "Effect of ambient temperature rise in the core temperature change in humans."Environmental Medicine. 45(2). 62-65 (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] KAWANOKUCHI Jun, FU Qi, CUI Jian, NITMI Yuki, KAMIYA Atsunori, MICHIKAMI Daisaku, IWASE Satoshi, MANO Tadaaki, SUZUMURA Akio: "Influence of vestibulo-sympathetic reflex on muscle sympathetic outflow during head-down tilt."Environmental Medicine. 45(2). 66-68 (2001)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] FU Qi, IWASE Satoshi, NIMI Yuki, KAMIYA Atsunori, MICHIKAMI Daisaku, MANO Tadaaki, SUZUMURA Akio: "Age-related changes in vasomotor reflex control of calf venous capacitance responses to lower body negative pressure in humans."Japanese Journal of Physiology. 52. 69-76 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] FU Qi, IWASE Satoshi, NIIMI Yuki, KAMIYA Atsunori, MIGHIKAMI Daisaku, MANO Tadaaki, SUZUMURA Akio: "Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans."Japanese Journal of Physiology. 52. 77-84 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] COX James F, TAHVANAINEN Kari UO, KUUSELA Tom A, LEVINE Benjamin D, COOKE William H, MANO Tadaaki, IWASE Satoshi, SAITO Mitsuru, SUGIUAMA Yoshiki, ERTL Andrew C, BIAGGIONI Italo, DIEDRICH Andre, ROBERTSON Rose Marie, ZUCKERMAN Julie H, LANE Lynda D, RAY Chester A, WHITE Ronald J, PAWELGZYK James A, BUCKEY Jay C Jr., BAISCH Friedheim J, BLOMQVIST C Gunnar, ROBERTSON David, ECKBERG Dwain L.: "Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre."Journal of Physiology. 538.1. 309-320 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] LEVINE Benjamin D, PAWELCZYK James A, ERTL Andrew C, GOX James F, ZUCKERMAN Julie H, DIEDRICH Andre, BIAGGIONI Italo, RAY Chester A, SMITH Michael L, IWASE Satoshi, SAITO Mitsuru, SUGIUAMA Yoshiki, MANO Tadaaki, ZHANG Rong, IWASAKI Kenichi, LANE Linda D, BUCKEY Jay C Jr., COOKE William H, BAISCH Friedhelm J, ROBERTSON David, ECKBERG Dwain L, BLOMQVIST C Gunnar: "Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight."Journal of Physiology. 538.1. 331-340 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] IWASE Satoshi, GUI Jian, WALLIN B Gunnar, KAMIYA Atsunori, MANO Tadaaki: "Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans."Neuroscience Letters. 327. 37-40 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] MICHIKAMI Daisaku, KAMIYA Atsunori, FU Qi, NIIMI Yuki, IWASE Satoshi, MANO Tadaaki, SUZUMURA Akio: "Forearm elevation augments sympathetic activation during handgrip exercise in humans."Clinical Science (London). 103(3). 295-301 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] FU Qi, LEVINE Benjamin D, PAWELCZYK James A, ERTL Andrew C, DIEDRICH Andre, COX James F, ZUCKERMAN Julie H, RAY Chester A.SMITH Michael L, IWASE Satoshi, SAITO Mitsuru, SUGIYAMA Yoshiki, TADAAKI Mano, ZHANG Rong, IWASAKI Kenichi, LANE Lynda D, BUCKEY Jay C Jr., COOKE William H, ROBERTSON Rose Marie, BAISCH Friedheim J, BLOMQVIST C Gunnar, ECKBERG Dwain L, ROBERTSON David, BIAGGIONI Italo: "Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli before, during and after spaceflight."Journal of Physiology. 544.2. 653-664 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] IWASE Satoshi, EU Qi, NARITA Kenichi, MORIMOTO Eiichi, TAKADA Hiroki, MANO Tadaaki: "Effects of graded load of artificial gravity on cardiovascular function in humans."Environmental Medicine. 46. 29-32 (2002)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] MANO Tadaaki, IWASE Satoshi: "Sympathetic nerve activity in hypotension and orthostatic intolerance."Acta Physiologica Scandinavica. 177. 359-365 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] Eckberg Dwain L.: "Bursting into space."Acta Physiologica Scandinavica (for the Neurolab Autonomic Nervous System Team (including IWASE S)). 177. 299-311 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] OKAGAWA Tomoko, SUGENOYA Junichi, IWASE Satoshi, MANO Tadaaki, SUZUMURA Akio, MATSUMOTO Takao, SUGIYAMA Yoshiki: "Occurrence of the spinal reflex due to skin pressure in sudomotor and ocutaneous vasoconstrictor nerve system of humans."Auton Neurosci. 105. 62-70 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] KAMIYA Atsunori, MICHIKAMI Daisaku, FU Qi, IWASE Satoshi, HAYANO Junichiro, KAWADA Toru, MANO Tadaaki, SUNAGAWA Kenji: "Pathophysiology of orthostatic hypotension after bed rest : Paradoxical sympathetic withdrawal."American Journal of Physiology Heart and Circulatory Physiology. 285. H1158-H1167 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] MICHIKAMI Daisaku, KAMIYA Atsunori, FU Qi, IWASE Satoshi, MANO Tadaaki, SUNAGAWA Kenji: "Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans."Journal of Applied Physiology. 96. 107-114 (2004)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] KAMIYA Atsunori, MICHIKAMI Daisaku, FU Qi, IWASE Satoshi, HAYANO Junichiro, KAWADA Toru, MANO Tadaaki, SUNAGAWA Kenji: "alpha-adrenergic vascular responsiveness to sympathetic nerve activity is intact after head-down bed rest in humans."American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 286. R151-R157 (2004)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] KONDO Masahide, IWASE Satoshi, MANO Tadaaki, KUZUHARA Shigeki: "Direct measurement of human sympathetic nerve conduction velocity."Muscle and Nerve. 29. 128-133 (2004)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] QIU Yunhai, FU Qi, WANG Xiaohong, TRAN Tuan Diep, INUI Koji, IWASE Satoshi, KAKIGI Ryusuke: "Microneurographic study of C fiber discharges induced by CO_2 laser stimulation in humans."Neuroscience Letters. 353. 25-28 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] WATANABE Tadashi, IWASE Satoshi, SAITO Kiyoshi, NAGATANI Tetsuya, YOSHIDA Jun: "Microneurographic evidence altered thermoregulatory sympathetic outflow to the skin in patients with hypothalamic dysfunction following removal of suprasellar tumors."Autonomic Neuroscience ; Basic and Clinical. (in press). (2004)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] KAMIYA Atsunori, MIGHIKAMI Daisaku, SHIOZAWA Tomoki, IWASE Satoshi, HAYANO Junichiro, KAWADA Toru, KENJI Sunagawa, MANO Tadaaki: "Bed rest attenuates sympathetic and pressor responses to isometric exercise in antigravity leg muscles in humans."Am J Physiol Regul Integr Comp Physiol. (in press).
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] HIRAYANAGI Kaname, KAMIYA Atsunori, IWASE Satoshi, MANO Tadaaki, SASAKI Tsuyoshi, OINUMA Miyuki, YJIMA Kazuyoshi: "Autonomic cardiovascular changes during and after 14 days of head-down bed rest"Autonomic Neuroscience. (in press). (2004)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] HIRAYANAGI Kaname, IWASE Satoshi, KAMIYA Atsunori, MANO Tadaaki, SASAKI Tsuyoshi, Kazuyoshi Yajima: "Functional changes in autonomic nervous system and baroreceptor reflex induced by 14 days of 6°head-down bed rest"European Journal of Applied Physiology. (in press). (2004)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] TAKADA Hiroki, KITOKA Yoshiyuki, IWASE Satoshi, SHIMIZU yuuki, WATAMABE Tomoyuki, NAKAYAMA Meiho, MIYAO Masaru, MIHASHI Koshin: "Characteristic changes of sway of center of gravity with advancing age."Environmental Medicine. 47. 85-89 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] IWASE Satoshi, FU Qi, MORIMOTO Eiichi, TAKADA Hiroki, KAMIYA Atsunori, MICHIKAMI Daisaku, KAWANOKUCHI Jun, SHIOZAWA Tomoki, HIRAYANAGI Kaname, Ken'ichi IWASAKI, YJIMA Kazuyoshi, MANO Tadaaki: "Effectiveness of centrifuge-induced artificial gravity with ergometric exercise as a countermeasure during simulated microgravity exposure in humans."Environmental Medicine. 47. 76-80 (2003)
  • 説明: 「研究成果報告書概要(欧文)」より
• [文献書誌] IWASE S, MANO T, KAMIYA A, et al.: "Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans"Autonomic Nueroscience : Basic and Clinical. 95. 141-145 (2002)
• [文献書誌] IWASE S, CUI J, WALLIN B G, et al.: "Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans"Neuroscience Letters. 327. 37-40 (2002)
• [文献書誌] Okagawa T, Sugenoya J, Iwase S et al.: "Occurance of the spinal reflex due to skin pressure in sudomotor and ocutaneous vasoconstrictor nerve system of humans"Autonomic Nueroscience : Basic and Clinical. 105. 62-70 (2003)
• [文献書誌] Kamiya K, Michikami D, Fu Q, Iwase S, et al.: "Pathophysiology of orthostatic hypotension after bed rest : Paradoxical sympathetic withdrawal"American Journal of Physiology Heart & Circulatory Physiology. 285. H1158-H1167 (2003)
• [文献書誌] Michikami D, Kamiya K, Fu Q, Iwase S, et al.: "Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans"Journal of Applied Physiology. 96. 107-114 (2004)
• [文献書誌] Kondo M, Iwase S, Mano T, Kuzuhara S: "Direct measurement of human sympathetic nerve conduction velocity"Muscle and Nerve. 29. 128-133 (2004)
• [文献書誌] 岩瀬 敏: "電場の医療応用"フジ・テクノシステム. 55/1005 (2004)
• [文献書誌] Iwase S, Mano T, Kamiya A, Niimi Y, Fu Q, Suzumura A: "Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans"Autonomic Neuroscience : Basic & Clinical. 95. 141-145 (2002)
• [文献書誌] Fu Q, Iwase S, Niimi Y, Kamiya Y, Michikami D, Mano T, Suzumura A: "Age-related changes in vasomotor reflex control of calf venous capacitance responses to lower body negative pressure in human"Japanese Journal of Physiology. 52. 77-84 (2002)
• [文献書誌] Iwase S, Cui J, Wallin BG, Kamiya A, Mano T: "Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt"Neuroscience Letters. 327. 37-40 (2002)
• [文献書誌] Michikami D, Kamiya A, Fu Q, Niimi Y, Iwase S, Mano T, Suzumura A: "Forearm elevation augments sympathetic activation during handgrip exercise in humans"Clinical Science (London). 103. 295-301 (2002)
• [文献書誌] Iwase S, Cui J, Wallin BG, Mano T: "Effect of ambient temperature rise on the core temperature change in humans"Environmental Medicine. 45. 62-65 (2001)
• [文献書誌] Fu Q, Levine BD, Iwase S, Saito M, et al.: "Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli before, during and after spaceflight"Journal of Physiology. 544-2. 653-664 (2002)
• [文献書誌] Sawasaki N, Iwase S, Mano T: "Effect of skin sympathetic nerve response to local or systemic cold exposure on thermoregulatory functions in humans"Autonomic Neuroscience : Basic & Clinical. 87. 274-281 (2001)
• [文献書誌] Michikami D, Iwase S, Kamiya A, Fu Q, Mano T: "Interrelations of vasoconstrictor sympathetic outflow to skin and core temperature duirng unilateral sole heating in humans"Autonomic Neuroscience : Basic & Clinical. 91. 55-61 (2001)
• [文献書誌] Fu Q, Iwase S, Niimi Y, Kamiya A, Kawanokuchi J, Cui J, Mano T, Suzumura A: "Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt"Am J Physiol Regul Integr Comp Physiol. 281. R778-R785 (2001)
• [文献書誌] Cui J, Iwase S, Mano T, Katayama N, Mori S: "Muscle sympathetic outflow during horizontal linear acceleration in humans"Am J Physiol Regul Integr Comp Physiol. 292. R625-R634 (2001)
• [文献書誌] Iwase S, Cui J, Wallin BG, Mano T: "Effect of ambient temperature rise on the core temperature change in humans"Environmental Medicine. 45. 62-65 (2001)
• [文献書誌] Iwase S, Mano T, Kamiya A, Niimi Y, Fu Q, Suzumura A: "Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans"Autonomic Neuroscience Basic & Clinical. 95. 141-145 (2002)