染色体の動態制御機構による多様な生命体の維持・継承

• 研究課題/領域番号: 13CE2006
• 研究種目: 特別推進研究(COE)
• 配分区分: 補助金
• 研究機関: 京都大学
• 研究代表者: 柳田 充弘 京都大学, 生命科学研究科, 研究員 (80025428)
• 研究分担者: 武田 俊一 京都大学, 医学研究科, 教授 (60188191) ; 竹安 邦夫 (竹安 国夫) 京都大学, 生命科学研究科, 教授 (40135695) ; 石川 冬木 京都大学, 生命科学研究科, 教授 (30184493) ; 松本 智裕 京都大学, 放射線生物研究センター, 教授 (80212223) ; 西田 栄介 京都大学, 大学院・生命科学研究科, 教授 (60143369)
• 研究期間 (年度): 2001 – 2005
• 研究課題ステータス: 完了 (2005年度)
• 配分額: 2,231,000千円 (直接経費: 1,820,000千円、間接経費: 411,000千円); 2005年度: 364,000千円 (直接経費: 280,000千円、間接経費: 84,000千円); 2004年度: 403,000千円 (直接経費: 310,000千円、間接経費: 93,000千円); 2003年度: 494,000千円 (直接経費: 380,000千円、間接経費: 114,000千円); 2002年度: 520,000千円 (直接経費: 400,000千円、間接経費: 120,000千円); 2001年度: 450,000千円 (直接経費: 450,000千円)
• キーワード: 染色体 / 原動体 / 紡錘体 / 酵母 / DNA修復 / テロメア / 原子間力顕微鏡 / 細胞分裂周期 / 生命継承 / 細胞周期 / 修復 / 組み換え

研究概要

我々の研究目的は、多様な生命体の維持・継承の根幹である、染色体のダイナミックスの精密な制御と染色体構造維持との理解である。これらの機構には、DNA複製と修復、複製の結果生じた2本の姉妹染色分体間の合着(コヒーシン)、細胞分裂M期での染色体凝縮(コンデンシン)、染色体と細胞骨格(紡錘体)との接点(動原体)の形成、すべての動原体に紡錘体が結合していることをチェックする機構(紡錘体チェックポイント)、末端(テロメア)の形成が含まれる。
柳田グループは、分裂酵母とヒト細胞両方で、動原体で働く相同分子を複数種類、遺伝学とマススペクトロメーターによる解析とを併用して同定し、その機能解析のデータを発表した。またコヒーシンとコンデンシンは、M期以外では、DNA修復にも関与することを証明した。他のグループは以下のテーマで成果をあげた:Atomic force microscopyを使って水溶液のなかのテロメアやコンデンシンを電顕レベルの分解能で観察(竹安)、紡錘体が正常に結合した後にチェックポイントが解除される機構(松本)、Polo like kinaseによるG2→M期移行の誘導機構(西田)、カエル卵抽出液による試験管内テロメア複製の成功(石川)、ニワトリ体細胞株(DT40)の遺伝子破壊による相同組み換え分子群の機能解析(武田)。以上に説明したように、本COEグループでは、酵母、カエル卵(in vitro)、ニワトリ体細胞株、ヒト細胞を用いて、染色体に関連する各生化学反応と各反応間の密接な相互作用とを統合的に解明できた。また、Atomic force microscopyを使った新しい染色体解析方法の開発(竹安)、およびメダカの遺伝子石壊の実験系を樹立する(武田)ことに成功した。

研究成果

• [雑誌論文] Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase. (2006)
  • 著者名/発表者名: Nagao, K., et al.
  • 雑誌名: Genes Cells 11 ページ: 247-260
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Coordinated Requirements of Human Topo II and Cohesin for Metaphase Centromere Alignment under Mad2-dependent Spindle Checkpoint (2006)
  • 著者名/発表者名: Toyoda, Y., et al.
  • 雑誌名: Mol. Biol. Cell 17 ページ: 2287-2302
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Histone H2B Mutations in Inner Region Affect Ubiquitination, Centromere Function, Silencing and Chromosome Segregation. (2006)
  • 著者名/発表者名: Maruyama, T., et al.
  • 雑誌名: EMBO J. (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Critical roles for Polζ in Cellular Tolerance to Nitric Oxide induced DNA Damage. (2006)
  • 著者名/発表者名: Xiaohua, W., et al.
  • 雑誌名: Cancer Res. 66 ページ: 748-754
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage. (2006)
  • 著者名/発表者名: Takenaka, K., et al.
  • 雑誌名: J. Biol. Chem. 281 ページ: 2000-2004
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. (2006)
  • 著者名/発表者名: Hochegger, H., et al.
  • 雑誌名: EMBO J. 25 ページ: 1305-1314
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Bacterial nucleoid dynamics : Oxydative stress response in Staphylococcus aureus (2006)
  • 著者名/発表者名: Morikawa, K., et al.
  • 雑誌名: Genes to Cells 11 ページ: 409-423
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Comparative structural biology of the genome : Nano-scale imaging of single nucleus from different kingdoms reveals the chromatin built up on a 40 nm structural unit. (2006)
  • 著者名/発表者名: Kobori, T., et al.
  • 雑誌名: J. Electron. Microscopy (Tokyo) (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Protective effect of vitamin C against double-strand breaks in reconstituted chromatin visualized by single-molecule observation. (2006)
  • 著者名/発表者名: Yoshikawa, Y., et al.
  • 雑誌名: Biophys. J. 90 ページ: 993-999
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Hydrodynamic radius of circular DNA is larger than that of linear DNA. (2006)
  • 著者名/発表者名: Araki, S., et al.
  • 雑誌名: Chem. Physics. Lett. 418 ページ: 255-259
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Fast-scanning atomic force microscopy revealed the molecular mechanism of DNA cleavage by Apal endonuclease. (2006)
  • 著者名/発表者名: Yokokawa, M., et al.
  • 雑誌名: IEE Proc. Nanobiotechnology (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Interaction of Skp1 with CENP-E at the midbody is essential for eytokinesis. (2006)
  • 著者名/発表者名: Liu, D., et al.
  • 雑誌名: Biochem. Biophys. Res. Comm. (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Atomic Force Microscopy Dissects the Hierarchy of Genome Architectures in Eukaryote, Prokaryote and Chloroplast. (2006)
  • 著者名/発表者名: Ohniwa, R.L., et al.
  • 雑誌名: J. Microscopy ＆ Microanalysis 52(in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Force measurement between importin α and importin β by using glutathione-coupled cantilever. (2006)
  • 著者名/発表者名: Takahashi, H., et al.
  • 雑誌名: Advances in Single-Molecule Research for Biology ＆ Nanoscience (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Transcriptional Coactivator PC4, A Chromatin-associated Protein, Induces Chromatin Condensation. (2006)
  • 著者名/発表者名: Das, C., et al.
  • 雑誌名: Cell Mol. Biol. (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • 著者名/発表者名: Nishiyama, A., et al.
  • 雑誌名: EMBO J. 25 ページ: 575-584
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A defect in protein famesylation suppresses a loss of Schizosaccharomyces pombe tsc2^+, a homolog of the human gene predisposing tuberous sclerosis complex (TSC). (2006)
  • 著者名/発表者名: Nakase, Y., et al.
  • 雑誌名: Genetics (in press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Coordinated Requirements of Human Topo II and Cohesin for Metaphase Centromere Alignment under Mad2-dependent Spindle Checkpoint Surveillance. (2006)
  • 著者名/発表者名: Toyoda, Y., et al.
  • 雑誌名: Mol. Biol. Cell 17 ページ: 2287-2302
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Critical roles for Pol ζ in Cellular Tolerance to Nitric Oxide induced DNA Damage. (2006)
  • 著者名/発表者名: Xiaohua, W., et al.
  • 雑誌名: Cancer Res. 66 ページ: 748-754
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Bacterial nucleoid dynamics : Oxydative stress response in Staphylococcus aureus. (2006)
  • 著者名/発表者名: Morikawa, K., et al.
  • 雑誌名: Genes Cells 11 ページ: 409-423
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Hydrodynamic radius of circular DNA is larger than that of linear DNA. (2006)
  • 著者名/発表者名: Araki, S., et al.
  • 雑誌名: Chem. Physics Lett. 418 ページ: 255-259
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Force measurement between importin α and importin β by using glutathione-coupled cantilever. (2006)
  • 著者名/発表者名: Takahashi, -H., et al.
  • 雑誌名: Advances in Single-Molecule Research for Biology ＆ Nanoscience
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing tuberous sclerosis complex (TSC). (2006)
  • 著者名/発表者名: Nakase, Y., et al.
  • 雑誌名: Genetics (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Distinct modes of DNA damage response in S.pombe G0 and vegetative cells (2006)
  • 著者名/発表者名: Mochida, S., Yanagida, M.
  • 雑誌名: Genes Cells 11 ページ: 13-27
• [雑誌論文] Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase (2006)
  • 著者名/発表者名: Nagao, K., Yanagida, M.
  • 雑誌名: Genes Cells 11 ページ: 247-260
• [雑誌論文] T. The selective continues linxage of centromeres from mitosis to interphase in the absence of mammalian separase (2006)
  • 著者名/発表者名: Kumada, K., Yao, R., Kawaguchi, T., Karasawa, M., Hoshikawa, Y., Ichikawa, K., Sugitani, Y., Imoto, I., Inazawa, J., Sugawara, M., Yanagida, M., Noda, T.
  • 雑誌名: J Cell Biol 172 ページ: 835-846
• [雑誌論文] Characterization of Schistosoma mansoni Sds homolog, a Leucine Rich Repeat protein, that interacts with protein phosphatase type 1 and interrupts a G2/M cell-cycle checkpoint (2006)
  • 著者名/発表者名: Daher, W., Cailliau, K., Takada, K., Pierrot, C., Khayath, N., Dissous, C., Capron, M., Yanagida, M., Browaeys.E., Khalife, J.
  • 雑誌名: Biochem J
• [雑誌論文] Coordinated Requirements of Human Topo II and Cohesin for Metaphase Centromere Alignment under Mad2-dependent Spindle Checkpoint Surveillance (2006)
  • 著者名/発表者名: Toyoda, Y., Yanagida, M.
  • 雑誌名: Mol Biol Cell (in press)
• [雑誌論文] Critical roles for Polζ in Cellular Tolerance to Nitric Oxide induced DNA Damage. (2006)
  • 著者名/発表者名: Xiaohua W, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S, Yamazoe M
  • 雑誌名: Cancer Research 66 ページ: 748-754
• [雑誌論文] Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage. (2006)
  • 著者名/発表者名: Takenaka K, Ogi T, Okada T, Sonoda E, Guo C, Friedberg EC, Takeda S
  • 雑誌名: J.Biol.Chem. 281 ページ: 2000-2004
• [雑誌論文] Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. (2006)
  • 著者名/発表者名: Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A, Masutani M, Adachi N, Koyama H, de Murcia D, Takeda S
  • 雑誌名: EMBO J. (in press)
• [雑誌論文] Hydrodynamic radius of circular DNA is larger than that of linear DNA. (2006)
  • 著者名/発表者名: Araki, S., Nakai, T., Hizume, K., Takeyasu, K., Yoshikawa K.
  • 雑誌名: Chem.Physics Lett. 418 ページ: 255-259
  • NAID: 120000896371
• [雑誌論文] Protective effect or vitamin C against double-strand breaks in reconstituted chromatin visualized by single-molecule observation. (2006)
  • 著者名/発表者名: Yoshikawa, Y., Hizume, K., Oda, Y., Takeyasu, K., Araki, S., Yoshikawa, K.
  • 雑誌名: Biophys.J 90 ページ: 993-999
• [雑誌論文] Comparative structural biology of the genome : Nano-scale imaging of single nucleus from different kingdoms reveals the chromatin built up on a 40 nm structural unit. (2006)
  • 著者名/発表者名: Kobori, T., Kodama, M., Hizume, K., Yoshimura, S.H., Ohtani, T., Takeyasu, K.
  • 雑誌名: J.Electron Microscopy (in press)
• [雑誌論文] Atomic Force microscopy Dissects the Hierarchy of Genome Architectures in Eukaryote, Prokaryote and Chloroplast. (2006)
  • 著者名/発表者名: Ohniwa, RL., Morikawa, K., Kim, J., Kobori, T., Hizume, K., Matsumi, R., Atomi, H., Imanaka, T., Ohta, T., Yoshimura, S.H., Takeyasu, K.
  • 雑誌名: Microscopy & Microanalysis (in press)
• [雑誌論文] Fast-scanning atomic force microscopy revealed the molecular mechanism of DNA cleavage by ApaI endonuclease. (2006)
  • 著者名/発表者名: Yokokawa, Masatoshi., Yoshimura, S.H., Naito, Yasuyuki., Ando, Toshio., Yagi, Akira., Sakai, Nobuaki., Takeyasu, K.
  • 雑誌名: IEE Proc.Nanobiotechnology (in press)
• [雑誌論文] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • 著者名/発表者名: Nishiyama, A., Muraki, K., Saito, M., Ohsumi, K., Kishimoto, T., Ishikawa, F.
  • 雑誌名: EMBO J. 25 ページ: 575-584
• [雑誌論文] Regulation of Nuclear Proteasome by Rhp6/Ubc2 through Ubiquitination and Destruction of the Sensor and Anchor Cut8. (2005)
  • 著者名/発表者名: Takeda, K., et al.
  • 雑誌名: Cell 122 ページ: 393-405
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. (2005)
  • 著者名/発表者名: Hatanaka, A., et al.
  • 雑誌名: Mol. Cell Biol. 25 ページ: 1124-1134
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Multiple roles of vertebrate REV genes in DNA repair and recombination. (2005)
  • 著者名/発表者名: Okada, T., et al.
  • 雑誌名: Mol. Cell Biol. 25 ページ: 6103-6111
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. (2005)
  • 著者名/発表者名: Kikuchi, K., et al.
  • 雑誌名: Mol. Cell Biol. 25 ページ: 6948-6955
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. (2005)
  • 著者名/発表者名: Nojima, K., et al.
  • 雑誌名: Cancer Res. 65 ページ: 11704-11711
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Dual Roles for DNA Polymerase η in Homologous DNA Recombination and Translesion DNA Synthesis. (2005)
  • 著者名/発表者名: Kawamoto, T., et al.
  • 雑誌名: Mol. Cell 20 ページ: 793-799
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Phase transition in reconstituted chromatin. (2005)
  • 著者名/発表者名: Nakai, T., et al.
  • 雑誌名: Europhysics Letters 69 ページ: 1024-1030
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Linker Histone H1 per se Can Induce Three-Dimensional Folding of Chromatin Fiber. (2005)
  • 著者名/発表者名: Hizume, K., et al.
  • 雑誌名: Biochemistry 44 ページ: 12978-12989
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylationofemerininaxenopuseggcell-freesystem. (2005)
  • 著者名/発表者名: Hirano, Y., et al.
  • 雑誌名: J. Biol. Chem. 280 ページ: 39925-39933
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Telomere-Binding Protein Taz1 Establishes Swi6 Heterochromatin Independently of RNAi at Telomeres. (2005)
  • 著者名/発表者名: Kanoh, J., et al.
  • 雑誌名: Curr. Biol. 15 ページ: 1808-1819
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Alterations of DNA and Chromatin Structures at Telomeres, and Genetic Instability in Mouse Cells Defective in DNA Polymerase α. (2005)
  • 著者名/発表者名: Nakamura, M., et al.
  • 雑誌名: Mol. Cell Biol. 25 ページ: 11073-11088
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Oct-3/4 and sox2 regulate oct-3/4 gene in embryonic stem cells. (2005)
  • 著者名/発表者名: Okumura-Nakanishi, S., et al.
  • 雑誌名: J. Biol. Chem. 280 ページ: 5307-5317
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. (2005)
  • 著者名/発表者名: Takeda, K., et al.
  • 雑誌名: Cell 122 ページ: 393-405
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. (2005)
  • 著者名/発表者名: Hatanaka, A., et al.
  • 雑誌名: Moc. Cell Biol. 25 ページ: 1124-1134
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Fen-4 facilitates homologous recombination by removing divergent sequences at DNA break ends. (2005)
  • 著者名/発表者名: Kikuchi, K., et al.
  • 雑誌名: Mol. Cell Biol. 25 ページ: 6948-6955
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Linker histone H1 per se can induce three-dimensional folding of chromatin fiber. (2005)
  • 著者名/発表者名: Hizume, K., et al.
  • 雑誌名: Biochemistry 44 ページ: 12978-12989
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Dissection of Emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of Emerin in a Xenopus egg cell-free system. (2005)
  • 著者名/発表者名: Hirano, Y., et al.
  • 雑誌名: J. Biol. Chem. 280 ページ: 39925-39933
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Alterations of DNA and Chromatin Structures at Telomeres, and Genetic Instability in Mouse Cells Defective in DNA Polymerase α. (2005)
  • 著者名/発表者名: Nakamura, M., et al.
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• [雑誌論文] Identification of a Mad2-binding protein, Cmt2, and its role in mitosis. (2002)
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• [雑誌論文] Control of intracellular dynamics of mammalian Period proteins by casein kinase Iε (CKIε) and CKIδ in cultured cells. (2002)
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• [雑誌論文] The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. (2002)
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• [雑誌論文] Cnd2 has dual roles in mitotic condensation and interphase. (2002)
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• [雑誌論文] Involvement of Vertebrate Pol x in Rad18-independent Postreplication Repair of UV Damage. (2002)
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• [雑誌論文] Condensin Architecture and Interaction with DNA : Regulatory Non-SMC Subunits Bind to the Head of SMC Heterodimer. (2002)
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• [雑誌論文] Cohesin defects lead to premature sister chromatid separation, kinetochore dysfunction and spindle-assembly checkpoint activation. (2002)
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• [雑誌論文] Control of localization of a spindle checkpoint protein, Mad2 in fission yeast. (2002)
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• [雑誌論文] Role of fission yeast Tscl -Tsc2 complex in signaling and transport across cell membrane. (2002)
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• [雑誌論文] ldentification of a Mad2-binding protein, Cmt2, and its role in mitosis. (2002)
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• [雑誌論文] Control of intracellular dynamics of mammalian Period proteins by casein kinase Iε(CKIε) and CKI δ in cultured cells. (2002)
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• [雑誌論文] The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. (2002)
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• [雑誌論文] Plk1 promotes nuclear translocation of human Cdc25C during prophase. (2002)
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• [雑誌論文] Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal. (2002)
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• [雑誌論文] Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. (2001)
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• [雑誌論文] M phase-specific kinetochore proteins in fission yeast : microtubule- associating Dis1 and Mtc1 display rapid separation and segregation during anaphase. (2001)
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• [雑誌論文] Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres. (2001)
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• [雑誌論文] Single-molecule reaction analysis reveals the ATP-ADP-dependent conformational changes of chaperonin GroEL.
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• [雑誌論文] Comparative structural biology of the genome : Nano-scale imaging of single nucleus from different kingdoms reveals the chromatin built up on a 40 nm structural unit.
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• [雑誌論文] Transcriptional Coactivator PC4, A Chromatin-associated Protein, Induces Chromatin Condensation.
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• [雑誌論文] Single-molecule reaction analysis reveals the ATP-ADP-dependent conformational changes of chaperonin GroEL..
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• [図書] The dream of every chromosome; equal segregation for a healthy life of the host. Genome Instability and Cancer Development, Chapter3.3 (2006)
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  • 説明: 「研究成果報告書概要(和文)」より
• [図書] Nuclear Dynamics (2006)
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  • 出版者: Springer Verlag(in press)
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• [図書] Nuclear Dynamics (2006)
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• [図書] The dream of every chromosome ; equal segregation for a healthy life of the host. Genome Instability and Cancer Development, in Advances in Experimental Medicine and Biology (2005)
  • 著者名/発表者名: Matsumoto, T., et al.
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  • 説明: 「研究成果報告書概要(和文)」より
• [図書] Genome Instability and Cancer Development (2005)
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  • 出版者: Kluwer Academic Publishers
• [図書] The dream of every chromosome ; equal segregation for a healthy life of the host (2005)
  • 著者名/発表者名: Matsumoto, T., Yanagida, M.
  • 出版者: Genome Instability and Cancer Development, Kluwer Academic Publishers(印刷中)
• [図書] ナノバイオテクノロジー (2004)
  • 著者名/発表者名: 竹安 邦夫
  • 総ページ数: 180
  • 出版者: 共立出版
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• [図書] 細胞核のダイナミズム (2004)
  • 著者名/発表者名: 竹安邦夫, 米田悦啓
  • 総ページ数: 206
  • 出版者: シュプリンガー フェアラーク
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• [図書] ナノバイオロジー (2004)
  • 著者名/発表者名: 竹安 邦夫
  • 総ページ数: 180
  • 出版者: 共立出版
• [図書] 老化研究の最前線 (2002)
  • 著者名/発表者名: 石川冬木(編)
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• [図書] 遺伝子の構造と機能 (2001)
  • 著者名/発表者名: 山本雅之(編)
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• [文献書誌] Sakai, A., Hizume, K., Sutani, T., Takeyasu, K., Yanagida, M.: "Condensin but not cohesin heterodimeric SMC induces DNA reannealing through intermediary protein-protin assembly."EMBO J. 22. 2764-2775 (2003)
• [文献書誌] Matsumura, T., Yuasa, T., Hayashi, T., Obara, T., Kimata, Y., Yanagida, M.: "A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securing Plasmids"Genes Cells. 8. 341-355 (2003)
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• [文献書誌] Chen, E.S., Yanagida, M., Takahashi, K.: "Does a GATA factor make the bed for centromeric nucleosomes?"Cell Cycle. 2. 277-278 (2003)
• [文献書誌] Goshima, G., Kiyomitsu, T., Yoda, K., Yanagida M.: "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway"J Cell Biol. 160. 25-39 (2003)
• [文献書誌] Goshima, G., Iwasaki, O., Obuse, C., Yanagida, M.: "The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore"EMBO J.. 22. 2752-2763 (2003)
• [文献書誌] Mochida S., Esashi F., Aono, N., Tamai K., O'Connell, M.J., Yanagida, M.: "Regulation of checkpoint kinases through dynamic interaction with Crb2."EMBO J. 23. 418-428 (2004)
• [文献書誌] Sonoda, E., Okada, T., Zhao, GY., Tateishi, S., Araki, K., Yamaizumi, M., Yagi, T., Verkaik, N.S., van Gent D.C., Takata, M., Takeda, S.: "Multiple roles of Rev3, the catalytic subunit of polz in maintaining genome stability in vertebrates."EMBO J.. 22. 3188-3197 (2003)
• [文献書誌] Yu, D., Sonoda, E., Takeda, S., Huang, C.L.H., Pellegrini, L., Blundell, T.L., Venkitaraman, A.R.: "Dynamic control of Rad51 recombinase by self-association and interaction with Brca2."Mol Cell. 12(4). 1029-1041 (2003)
• [文献書誌] P.Vagnarelli1, C.Morrison, H.Dodson1, E.Sonoda, S.Takeda, W.C.Earnshaw: "Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores"EMBO Report. 5(2). 167-171 (2004)
• [文献書誌] Mizutani, A., Okada, T., Shibutani, S., Sonoda11, E., Hochegger, H., Nishigori, C., Miyachi, Y., Takeda, S., Yamazoe, M.: "Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair deficient cells."Cancer Research. in press. (2004)
• [文献書誌] Hochegger, H., Sonoda, E., Takeda, S.: "Post-Replication Repair in DT40 cells : Translesion Polymerases versus Recombinases"BioEssay(Review). 26(2). 151-158 (2004)
• [文献書誌] Yamazoe, M., Sonoda, E., Hochegger, H., Takeda, S.: "Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40."DNA Repair(Review). in press. (2004)
• [文献書誌] Hizume, K., Yoshmura, S.H., Wada, H., Takeyasu, K.: "Chromatin Reconstitution : Development of a Salt-dialysis Method Monitored by Nano-technology."Arch.Histol.Cytol.. 65. 405-413 (2003)
• [文献書誌] Yoshimura, S.H., Maruyama, H., Ishikawa, F., Ohki, R., Takeyasu, K.: "Molecular mechanisms of DNA end-loop formation by TRF2."Genes to Cells. In press. (2004)
• [文献書誌] Kim, J., Yoshimura, S.H., Hizume, K., Ishihama, A., Takeyasu, K.: "A fundamental structural unit of the Escherichia coli nucleoid revealed by nano-technology."Nucleic Acid Res. Under 2nd Revision. (2004)
• [文献書誌] Hizume, K., Yoshimura, S.H., Takeyasu, K.: "Atomic force microscopy demonstrates a critical role of DNA superhelicity in the nucleosome dynamics."Cell Biochem Biophy. In press. (2004)
• [文献書誌] Ogawa, S., Matsubayashi, Y., Nishida, E.: "An evolutionarily conserved gene required for proper microtubule architecture in Caenorhabditis elegans."Genes Cells. 9. 83-93 (2004)
• [文献書誌] Nakajima, H., Toyoshima, F., Taniguchi, E., Nishida, E.: "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate."J.Biol.Chem.. 278. 25277-25280 (2003)
• [文献書誌] Iwasa, H., Han, J., Ishikawa, F.: "Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway."Genes to Cells. 8. 131-144 (2003)
• [文献書誌] Takata, T., Ishikawa, F.: "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression."Biochem.Biophys.Res.Commun.. 301. 48714-48723 (2003)
• [文献書誌] Kanoh, J., Francesconi, S., Collura, A., Schramke, V., Ishikawa, F., Baldacci, G., Geli, V.: "The Fission Yeast spSet1p is a Histone H3-K4 Methyltransferase that Functions in Telomere Maintenance and DNA Repair in an ATM Kinase Rad3-dependent Pathway."J.Mol.Biol.. 326. 1081-1094 (2003)
• [文献書誌] Sadaie, M., Naito, T., Ishikawa, F.: "Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats."Genes Dev.. 17. 2271-2282 (2003)
• [文献書誌] Yoshimura, S.H, Maruyama, H., Ohki, R., Ishikawa, F., Takeyasu, K.: "Molecular mechanism of DNA end-loop formation by TRF2"Genes to Cells. 9. 205-218 (2004)
• [文献書誌] Ohki, R., Ishikawa, F.: "Telomere-bound TRF1 and TRF2 stall replication fork at telomeric repeats."Nucl.Acids Res. 32. 1627-1637 (2004)
• [文献書誌] Kanoh, J., Ishikawa, F.: "Composition and conservation of the telomeric complex."Cell.Mol.Life Sci.(review article). 60. 2295-2302 (2003)
• [文献書誌] Ishikawa, F.: "Cellular senescence, an unpopular yet trustworthy tumor suppressor mechanism."Cancer Sci.(review article). 94. 944-947 (2003)
• [文献書誌] Luo X., Tang Z., Xia, G., Wassmann K., Matsumoto T., Rizo, J., Yu H: "Conformational signaling by Mad2 in the mitotic spindle checkpoint"Nature Structural & Molecular Biology. In press. (2004)
• [文献書誌] Sakai, A., Hizume, K., Sutani, T., Takeyasu, K., Yanagida, M.: "Condensin but not cohesin heterodimeric SMC induces DNA reannealing through intermediary protein-protein assembly"EMBO J.. (in press). (2003)
• [文献書誌] Matsumura, T., Yuasa, T., Hayashi, T., Obara, T., Kimata, Y., Yanagida, M.: "A burte force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securing Plasmids"Genes Cells. (in press). (2003)
• [文献書誌] Goshima, G., Kiyomitsu, T., Yoda, K., Yanagida, M.: "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway"J. Cell Biol.. 160. 25-39 (2003)
• [文献書誌] Chen.E.S., Satoh.S., Yanagida.M., Takahashi.K.: "A Cell Cycle-Regulated GATA Factor Promotes Centromeric Localization of CENP-A in Fission Yeast"Mol. Cell. 11. 175-187 (2003)
• [文献書誌] Yanagida, M.: "The model unicellular eukaryote, Schizosaccharomyces pombe"Genome Biol. 3. (2003)
• [文献書誌] Nakamura, T., Nagao, K., Nakaseko, Y., Yanagida, M.: "Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast : pointed nuclear formation"Genes cells. 7. 1113-1124 (2002)
• [文献書誌] Aono, N., Sutani, T., Tomonaga, T., Mochida, S., Yanagida, M.: "Cnd2 has dual roles in mitotic condensation and interphase"Nature. 417. 197-202 (2002)
• [文献書誌] Takata, M., Tachiiri, S., Fujimori, A., Thompson, L.H., Miki, Y., Hiraoka, M., Takeda, S., Yamazoe, M.: "Conserved domains in the chicken homologue of BRCA2"Oncogene. 21. 1130-1134 (2002)
• [文献書誌] Yamashita, Y.M., Okada, T., Matsusaka, T., Sonoda, E., Cho, Z., Araki, K., Tateishi, S., Yamaizumi, M., Takeda, S.: "RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells"EMBO J. 21. 5558-5566 (2002)
• [文献書誌] Okada, T., Sonoda, E., Yamashita, Y.M., Koyoshi, S., Tateishi, S., Yamaizumi, M., Takata, M., Ogawa, O., Takeda, S.: "Involvement of Vertebrate Pol k in Rad18-independent Postreplication Repair of UV damage"J. Biol. Chem. 277. 48690-48695 (2002)
• [文献書誌] Hizume, K., Yoshimura, S.H., Wada H., Takeyasu, K.: "Efficient nucleosome reconstitution by salt-dialysis method monitored by nano-technology"Arch. Histol. Cytol.. (in press). (2003)
• [文献書誌] Yoshimura, S.H., Hizume, K., Murakami, A., Sutani, T., Takeyasu, K., Yanagida, M.: "Condensin Architecture and Interaction with DNA. Regulatory Non-SMC Subunits Bind to the Head of SMC Heterodimer"Curr Biol. 12. 508-513 (2002)
• [文献書誌] Bamba, C., Bobinnec, Y., Fukuda, M., Nishida, E.: "The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo"Curr. Biol.. 12. 503-507 (2002)
• [文献書誌] Toyoshima-Morimoto, F., Taniguchi.E., Nishida, E.: "PlK1 promotes nuclear translocation of human Cdc25C during prophase"EMBO Rep. 3. 341-348 (2002)
• [文献書誌] Taniguchi, E., Toyoshima-Morimoto, F., Nishida, E.: "Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal"J. Biol. Chem. 277. 48884-48888 (2002)
• [文献書誌] Kanoh, J., Francesconi, S., Collura A., Schramke, V., Ishikawa, F., Baldacci, G., Geli, V.: "The Fission Yeast spSet1p is a Histone H3-K4 Methyltransferase that Functions in Telomere Maintenance and DNA Repair in an ATM Kinase Rad3-dependent Pathway"J. Mol. Biol.. 326. 1081-1094 (2003)
• [文献書誌] Miyoshi, T., Sadaie, M., Kanoh, J., Ishikawa, F.: "Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast"J. Biol. Chem.. 278. 1924-1931 (2003)
• [文献書誌] Iwasa, H., Han, J., Ishikawa, F.: "Mitogen-activated protein kinase p38 defines the common senscence-signaling pathway"Genes to Cells. 8. 131-144 (2003)
• [文献書誌] Tkata, T., Ishikawa, F.: "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-and HEY2-mediated transcriptional repression"Biochem. Biophys. Res. Commun.. 301. 250-257 (2003)
• [文献書誌] Sakai, H., Urano, T., Ookata, K., Kim, M.-H., Hirai, Y., Saito, M., Nojima, Y., Ishikawa, F.: "MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase"J. Biol. Chem.. 277. 48714-48723 (2002)
• [文献書誌] Yago, M., Ohki, R., Hatakeyama, S., Fujita, T., Ishikawa, F.: "Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase"FEBS Letters. 520. 40-46 (2002)
• [文献書誌] Kim, M., X.Yuan, Okumura, S., Ishikawa, F.: "Successful inactivation of endogenous Oct-3/4 and c-mos genes in mouse preimplantation embryos and oocytes using short interfering RNAs"Biochem. Biophys. Res. Commun.. 296. 1372-1377 (2002)
• [文献書誌] Saito, M., Ishikawa, F.: "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2"J. Biol. Chem.. 277. 35434-35439 (2002)
• [文献書誌] Hoque, Md.T., Ishikawa, F.: "Cohesin defects lead to premature sister chromatid separation, kinetochore dysfunction and spindle-assembly checkpoint activation"J. Biol. Chem.. 277. 42306-42314 (2002)
• [文献書誌] Bandyopadhyay, A., Lakshmanan V, Matsumoto T, Chang EC, Maitra U.: "Moel and spInt6, the Fission Yeast Homologues of Mammalian Translation Initiation Factor 3 Subunits p66 (eIF3d) and p48(eIF3e), Respectively, Are Required for Stable Association of eIF3 Subunits"J. Biol. Chem.. 277. 2360-2367 (2002)
• [文献書誌] Ikui, A.E., Furuya, K., Yanagida, M., Matsumoto, T.: "Control of localization of a spindle checkpoint protein, Mad2 in fission yeast"J. Cell Sci.. 115. 1603-1610 (2002)
• [文献書誌] Matsumoto, S., Bandyopadhyay, A., Kwiatkowski, D.J., Maitra, U., Matsumoto, T.: "Role of fission yeast Tsc1-Tsc2 complex in signaling and transport across cell membrane"Genetics. 161. 1053-1063 (2002)
• [文献書誌] Habu, T., Kim, S.H., Weinstein, J., Matsumoto, T.: "Identification of a Mad2-binding protein, Cmt2, and its role in mitosis"EMBO J.. 21. 6419-6428 (2002)
• [文献書誌] Liu J., Furukawa, M., Matsumoto, T., Xiong, Y.: "NEDD8 Modification of CUL1 dissociates p120^<CAND1>, an inhibitor of CUL1-SKP1 binding and SCF ligases"Mol. Cell. 10. 1511-1518 (2002)
• [文献書誌] Aono, N., Sutani, T., Tomonaga, T., Mochida, S., Yanagida, M.: "Dual Roles of Cnd2lBarren, a Non-SMC Subunit of Condensin, in Mitotic Condensation and Interphase"Nature. (in press).
• [文献書誌] Toyoda, Y., Furuya, K., Goshima, G., Nagao, K., Takahashi, K., Yanagida, M.: "Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast"Curr.Biol.. 12. 347-358 (2002)
• [文献書誌] Nagao, K., Yanagida, M.: "Regulating sister chromatid separation by separase phosphorylation"Dev. Cell.. 2. 2-4 (2002)
• [文献書誌] Goshima, G., Yanagida, M.: "Time course analysis of precocious separation of sister centromeres in budding yeast: continuously separated or frequently reassociated?"Genes Cells. 6. 756-773 (2001)
• [文献書誌] Morishita, J., Matsusaka, T., Goshima, G., Nakamura, T., Tatebe, H., Yanagida, M.: "Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair"Genes Cells. 6. 743-763 (2001)
• [文献書誌] Nakaseko, Y.Goshima, G., Morishita, J., Yanagida, M.: "M phase-specific kinetochore proteins in fission yeast Microtubule-associating Disi and Mtc1 display rapi"Curr.Biol. 11. 537-549 (2001)
• [文献書誌] Nakaseko, Y, Yanagida, M.: "Cell biology. Gytoskeleton in the cell cycle"Nature. 412. 291-292 (2001)
• [文献書誌] M.Takata, M.S.Sasaki, S.Tachiiri, T.Fukushima, E.Sonoda, D.Schild, L.H.Thompson, S.Takeda: "Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs"Mol.Cell.Biol.. 21. 2858-2866 (2001)
• [文献書誌] T.Fukushima, M.Takata, C.Morrison, R.Araki, A.Fujimori, M.Abe, K.Tatsumi, M.Jasin, P.K.Dhar, E.Sonoda, T.Chiba, S.Takeda: "Genetic analysis of the DNA-dependent protein kinase reveals an inhijbitory role of Ku in late S-G2 phase DNA double-strand break"Jornal of Biological Chemistry. 276. 44413-44418 (2001)
• [文献書誌] Sonoda, E., Matsusaka, T., Morrison, C., Vagnarelli, P., Hoshi, O., Ushiki, T., Nojima, K., Fukagawa, T., Waizenegger, I.C., Peters, J.-M., Earnshaw, W.C., Takeda, S.: "Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells"Developmental Cell. 1. 759-770 (2001)
• [文献書誌] E.Sonoda, C.Morrison, Y.M.Yamashita, M.Takata, S.Takeda: "Reverse genetic Studies of homologous DNA recombination using the chicken B lymphocyte line, DT4O"Philosophical Transactions of the Royal Society Series B. 356. 111-117 (2001)
• [文献書誌] E.Sonoda, M.Takata, Y.M.Yamashita, C.Morrison, S.Takeda: "Homologous DNA recombination in vertebrate cells"Proc. Natl. Acad. Sci. USA.. 98. 8388-8394 (2001)
• [文献書誌] P.K.Dhar, E.Sonoda, A.Fujimori, Y.M.Yamashita, S.Takeda: "Experimental evidence in support of chicken DT4O cell line as a unique model for DNA repair studies"The Journal of Environmental Pathology, Toxicology and Oncology. (in press). (2001)
• [文献書誌] S.H.Yoshimura, K.Hizume, A.Murakami, T.Sutani, K.Takeyasu, M.Yanagida.: "Condensin Architecture and Intaraction with DNA: Regulatory Non-SMC Subunits Bind to SMC Heterodimer and Restrain its Assembly on DNA"Current Biology. 19. 508-513 (2002)
• [文献書誌] 吉村成弘, 竹安邦夫: "原子間力顕微鏡と分子生物学の接点〜遺伝子のナノバイオロジー〜"電子顕微鏡. 36. 182-188 (2001)
• [文献書誌] Sakaue, S., K.Yoshikawa, S.H.Yoshimura, K.Takeyasu: "Histone Core Slips along DNA and Prefers Positioning at the Chain End"Phys. Rev. Lett.. 87. (2001)
• [文献書誌] Toyoshima-Morimoto, F., Taniguchi, E., Nishida, E.: "Plk1 promotes nuclear translocation of human Cdc25CG during prophase"EMBO Reports. (in press). (2002)
• [文献書誌] Bamba, C., Bobinnec, Y., Fukuda, M., Nishida, E.: "The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo"Curr. Biol.. (in press). (2002)
• [文献書誌] Akashi, M., Tsuchiya, Y., Yoshino, T., Nishida, E.: "Control of intracellular dynamics of mammalian Period proteins by casein kinase Iε (CKIε) and CKIδ in cultured cells"Mol.Cell.Biol.. 22. 1693-1703 (2002)
• [文献書誌] Matsubayashi, Y., Fukuda, M., Nishida, E.: "Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells"J.Biol.Chem.. 276. 41755-41760 (2001)
• [文献書誌] Hoque, T., F.Ishikawa.: "Human chromatid cohesin component hRad2l is phosphorylated in M phase and associated with metaphase centromeres"J.Biol. Chem.. 276. 276
• [文献書誌] Ohki, R., T.Tsurimoto, F.Ishikawa.: "In vitro reconstitution of the end-replication problem"Mol. Cell. Biol.. 21. 5753-5766 (2001)
• [文献書誌] Kuramoto, M., K.Ohsumi., T.Kishimoto, F.Ishikawa.: "Identification and analyses of the Xenopus TELRT gene that encodes the catalytic subunit of telomerase"Gene. 277. 101-110 (2001)
• [文献書誌] Kanoh, J., F.Ishikawa.: "SpRap1 and spRifi, recruited to telomeres by Taz1, are essential for telomere function in fission yeast"Curr.Biol.. 11. 1624-1630 (2001)