異種シナプス間競合原理に基づく小脳神経回路発達の分子機構

• 研究課題/領域番号: 14208091
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 神経解剖学・神経病理学
• 研究機関: 北海道大学
• 研究代表者: 渡辺 雅彦 北海道大学, 大学院・医学研究科, 教授 (70210945)
• 研究分担者: 深谷 昌弘 北海道大学, 大学院・医学研究科, 助手 (10360900) ; 狩野 方伸 金沢大学, 大学院・医学研究科, 教授 (40185963)
• 研究期間 (年度): 2002 – 2004
• 研究課題ステータス: 完了 (2004年度)
• 配分額: 54,470千円 (直接経費: 41,900千円、間接経費: 12,570千円); 2004年度: 10,400千円 (直接経費: 8,000千円、間接経費: 2,400千円); 2003年度: 10,400千円 (直接経費: 8,000千円、間接経費: 2,400千円); 2002年度: 33,670千円 (直接経費: 25,900千円、間接経費: 7,770千円)
• キーワード: 小脳 / プルキンエ細胞 / シナプス形成 / 平行繊維 / 登上繊維 / グルタミン酸受容体 / 発達 / 遺伝子改変マウス / 平行線維 / 登上線維 / カルシウムチャネル / P / Q型

研究概要

プルキンエ細胞に対する平行線維と登上線維によるシナプス回路発達の過程は、回路発達研究に最も適したモデル系のひとつである。平行線維シナプスに選択的なグルタミン酸受容体δ2の遺伝子ノックアウトマウスの解析から、この分子が平行線維シナプス側の強化分子として機能し、その欠失により平行線維終末とプルキンエ細胞スパインの間のシナプス結合率が低下しフリースパインが生じることを見い出した(Kurihara et al., 1997, J. Neurosci. 17:9613-9623:下図参照)。
今回、平行線維支配の弱まった環境において、もう一つの入力線維である登上線維支配がどのように変化していることを神経トレーサー標識、蛍光多重染色、電顕解析法などを用いて解析した。その結果、遠位樹状突起に出現したフリースパインを目がけて、登上線維支配の遠位拡大が生じ、これが周囲のプルキンエ細胞に及ぶことにより登上線維による多重支配が生じた(Hahimoto et al, 2001; J.Neurosci. 21:9701-9712; Ichikawa et al., 2002, J.Neurosci. 22:8487-8503)。これらの事実は、プルキンエ細胞のシナプス回路が異種入力線維間の競合を基盤として樹状突起に対するドメイン的支配が確立し、ここでδ2が平行線維シナプス側の強化分子機構として機能していることを示している。同時に、登上線維側にも強化分子機構が存在し、δ2と拮抗する形で平行線維支配の過度な近位化(拡大化)を防いでいる可能性をも示唆する。その拮抗分子機構が、P/Q型カルシウムチャネルがその役割を担っていることも明らかすることができた(Miyazaki et al., 2004, J. Neurosci. 24:1734-1743)。

研究成果

• [雑誌論文] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on developing cerebellar Purkinje cells (2004)
  • 著者名/発表者名: Miyazaki, M., Hashimoto, K., Shin H.-S., Kano, M., Watanabe, M.
  • 雑誌名: J.Neurosci. 24 ページ: 1734-1743
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • 著者名/発表者名: Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe.M., Fukaya, M., Ide, C.
  • 雑誌名: Genes Cells 9 ページ: 1-14
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. (2004)
  • 著者名/発表者名: Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., Hirabayashi, Y.
  • 雑誌名: J.Biol.Chem. 279 ページ: 3573-3577
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • 著者名/発表者名: Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe, M., Somogyi, P.
  • 雑誌名: Eur.J.Neurosci. 19 ページ: 552-569
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Two distinct classes of muscarinic action on hippoccampal inhibitory synapses : M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling. (2004)
  • 著者名/発表者名: Fukudome, Y., Ohno-Shosaku, T., Matsui, M., Omori, Y., Fukaya, M., Taketo, M., Watanabe, M., Manabe, M., Kano, M.
  • 雑誌名: Eur.J.Neurosci. 19 ページ: 2682-2692
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-brain barrier. (2004)
  • 著者名/発表者名: Nakashima, T., Tomi, M., Katayama, K., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • 雑誌名: J.Neurochem. 89 ページ: 1454-1461
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • 著者名/発表者名: Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. 20 ページ: 144-160
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Immunolocalization of metabotropic glutamate receptor 1a (mGluR1a) in distinct classes of interneuron in the CA1 region of the rat hippocampus. (2004)
  • 著者名/発表者名: Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe, M., Somogy, P.
  • 雑誌名: Hippocampus 14 ページ: 193-215
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen unmasking (2004)
  • 著者名/発表者名: Nagy, G.G., Al-Ayyan, M., Andrew, D., Fukaya, M., Watanabe, M., Todd, A.J.
  • 雑誌名: J.Neurosci. 24 ページ: 5766-5777
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] NMDA Receptor GluRe/NR2 subunits are essential for postsynaptic localization and protein stability of GluRz1/NR1 subunit. (2004)
  • 著者名/発表者名: Abe, M., Fukaya, M., Yagi, T., Mishina, M., Watanabe, M., Sakimura, K.
  • 雑誌名: J.Neurosci. 24 ページ: 9292-9304
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. (2004)
  • 著者名/発表者名: Hama, K., Aoki, J., Fukaya, M., Kishi, Y., Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe, M., Chun, J., Arai, H.
  • 雑誌名: J.Biol.Chem. 279 ページ: 17634-17639
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Changes of high-affinity choline transporter expression during degeneration and regeneration of hypoglossal nerves in mice. (2004)
  • 著者名/発表者名: Oshima, S., Yamada, K., Shirakawa, T., Watanabe, M.
  • 雑誌名: Neurosci.Lett. 97 ページ: 97-101
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (2004)
  • 著者名/発表者名: Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I.
  • 雑誌名: Mol Brain Res. 125 ページ: 60-75
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Functional expression of rat ABCG2 and its enhancement by astrocyte-derived soluble factor(s). (2004)
  • 著者名/発表者名: Hori, S., Ohtsuki, S., Tachikawa, M., Kimura, N., Kondo, T., Watanabe, M., Nakashima, E., Terasaki, T.
  • 雑誌名: J.Neurochem. 90 ページ: 526-536
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. (2004)
  • 著者名/発表者名: Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K., Yamazaki, C., Fujita, S.C., Manabe, T., Nukina, N.
  • 雑誌名: Neurosci.Lett. 369 ページ: 173-178
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B cclathrin adaptor. (2004)
  • 著者名/発表者名: Nakatsu, F., Okada, M., Mori, F., Kamazawa, N., Iwasa, H., Zhu, G., Kasagi, Y., Kamiya, H., Harada, A., Nishimura, K., Takeuchi, A., Miyazaki, T., Watanabe, M., Yuasa, S., Manabe, T., Wakabayashi, K., Kaneko, S., Saito, T., Ohno, H.
  • 雑誌名: J.Cell Biol. 167 ページ: 293-302
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Upreguration of GluR2 decrease intracellular Ca2+ following ischemia in developing gerbils. (2004)
  • 著者名/発表者名: Oguro, K., Miyawaki, T., Yokota, H., Kato, K., Kamiya, T., Katayama, Y., Fukaya, M., Watanabe, M., Shimazaki, K.
  • 雑誌名: Neurosci.Lett. 364 ページ: 101-105
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Signaling complex formation of phospholipase Cb4 with mGluR1a and IP3R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • 著者名/発表者名: Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. 20 ページ: 2929-2944
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A novel action of stargazin as an enhancer of AMPA receptor activity. (2004)
  • 著者名/発表者名: Yamazaki, M., Ohno-Shosaku, T., Fukaya, M., Kano, M., Watanabe, M., Sakimura, K.
  • 雑誌名: Neurosci.Res. 50 ページ: 369-374
  • NAID: 10023901633
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Synaptic distribution of the NR1, NR2A, and NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique. (2004)
  • 著者名/発表者名: Nagy, G.G., Watanabe.M., Fukaya, M., Todd, R.
  • 雑誌名: Eur.J.Neurosci 20 ページ: 3301-3312
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on Developing cerebellar Purkinje cells. (2004)
  • 著者名/発表者名: Miyazaki, M., Hashimoto, K., Shin H.-S., Kano, M., Watanabe, M.
  • 雑誌名: J.Neurosci. 24 ページ: 1734-1743
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • 著者名/発表者名: Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe.M., Fukaya, M., Ide, C.
  • 雑誌名: Genes Cells. 9 ページ: 1-14
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] GABAergic basket cells expressing cholecystokinin contain Vesicular glutamate transporter type 3 (VGLUTs) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • 著者名/発表者名: Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe, M., Somogyi, P.
  • 雑誌名: Eur.J.Neurosci. 19 ページ: 552-569
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Distinct cellular expressions of creatine synthetic enzyme GAMT And creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • 著者名/発表者名: Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. 20 ページ: 144-160
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Immunolocalization of metabotropic glutamate receptor 1a (mGluR1a)in distinct classes of interneuron in the CA1 region of the rat hippocampus. (2004)
  • 著者名/発表者名: Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe M., Somogy, P.
  • 雑誌名: Hippocampus. 14 ページ: 193-215
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen unmasking method. (2004)
  • 著者名/発表者名: Nagy, G.G., AI-Ayyan, M., Andrew, D., Fukaya, M., Watanabe, M., Todd, A.J.
  • 雑誌名: J.Neurosci. 24 ページ: 5766-5777
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] NMDA Receptor GluRe/NR2 subunits are essential for postsynaptic localization and protein stability of GluRz1/NR1 subunit. (2004)
  • 著者名/発表者名: Abe, M., Fukaya, M., Yagi, T., Mishina, M., Watanabe.M., Sakimura, K.
  • 雑誌名: J.Neurosci. 24 ページ: 9292-9304
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. (2004)
  • 著者名/発表者名: Hama, K., Aoki, J., Fukaya, M., Kishi, Y., Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe, M, Chun, J., Alai, H.
  • 雑誌名: J.Biol.Chem. 27 ページ: 17634-17639
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Changes of high-affinity chorine transporter expression during degeneration and regeneration of hypoglossal nerves in mice. (2004)
  • 著者名/発表者名: Oshima, S., Yamada, K., Shirakawa, T., Watanabe, M.
  • 雑誌名: Neurosci.Lett. 97 ページ: 97-101
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Signaling complex formation of phospholipase Cb4 with mGluR1 a and IP3R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • 著者名/発表者名: Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. 20 ページ: 2029-2944
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Synaptic distribution of the NR1, NR2A, NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique. (2004)
  • 著者名/発表者名: Nagy, G.G., Watanabe, M., Fukaya, M., Todd, R.
  • 雑誌名: Eur.J.Neurosci. 20 ページ: 3301-3312
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • 著者名/発表者名: Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe, M., Fukaya, M., Ide, C.
  • 雑誌名: Genes Cells 9 ページ: 1-14
• [雑誌論文] GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • 著者名/発表者名: Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe, M., Somogyi, P.
  • 雑誌名: Eur.J.Neurosi. 19 ページ: 552-569
• [雑誌論文] Distinct cellular expression of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • 著者名/発表者名: Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. 20 ページ: 144-160
• [雑誌論文] Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (2004)
  • 著者名/発表者名: Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I.
  • 雑誌名: Mol Brain Res. 128 ページ: 60-75
• [雑誌論文] Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apoliporotein E4 instead of mouse apoliporotein E. (2004)
  • 著者名/発表者名: Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K., Yamazaki, C., Fujita, S.C., Manabe, T., Nukina, N.
  • 雑誌名: Neurosci.Lett. 369 ページ: 173-178
• [雑誌論文] Signaling complex formation of phospholipase Cb4 with mGluR1a and IP3 R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • 著者名/発表者名: Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci 20 ページ: 2929-2944
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  • 著者名/発表者名: Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M
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  • 説明: 「研究成果報告書概要(和文)」より
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  • 著者名/発表者名: Kakizawa S, Yamada K, Watanabe M, Kano M.
  • 雑誌名: Eur J Neurosci 17 ページ: 545-554
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. (2003)
  • 著者名/発表者名: Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M
  • 雑誌名: Proc Natl Acad Sci USA 100 ページ: 4855-4860
  • 説明: 「研究成果報告書概要(和文)」より
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  • 著者名/発表者名: Shibata, T.
  • 雑誌名: Dev.Brain Res. 140 ページ: 263-268
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurones in the rat hippocampus. (2003)
  • 著者名/発表者名: Somogyi, P.
  • 雑誌名: Eur.J.Neurosci. 17 ページ: 2503-2520
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Developmental switching of vesicular glutamate transporters at parallel fiber-Purkinjecell synapses. (2003)
  • 著者名/発表者名: Miyazaki, T.
  • 雑誌名: Eur.J.Neurosci. 17 ページ: 2563-2572
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb. (2003)
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  • 著者名/発表者名: Miyata, M.
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• [雑誌論文] Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. (2003)
  • 著者名/発表者名: Jourdi, H.
  • 雑誌名: Dev.Biol. 263 ページ: 216-230
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua. (2003)
  • 著者名/発表者名: Takahashi, Y.
  • 雑誌名: Neurol. 61 ページ: 891-896
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Novel neuroglial and glioglial relationships mediated by L-serine metabolism. (2003)
  • 著者名/発表者名: Furuya, S., Watanabe, M.
  • 雑誌名: Arch.Histol.Cytol. 66 ページ: 109-121
  • NAID: 10011992603
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneurial fibroblasts along sciatic nerves and its upregulation after crush injury. (2003)
  • 著者名/発表者名: Yamashita, N.
  • 雑誌名: Arch.Histol.Cytol. 66 ページ: 429-436
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Neutral amino acid transporter ASCI1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries. (2003)
  • 著者名/発表者名: Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M
  • 雑誌名: J Neurosci. 23 ページ: 550-560
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development. (2003)
  • 著者名/発表者名: Kakizawa S, Yamada K, Watanabe M, Kano M
  • 雑誌名: Eur J Neurosci. 17 ページ: 545-554
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. (2003)
  • 著者名/発表者名: Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M
  • 雑誌名: Proc Natl Acad Sci USA. 100 ページ: 4855-4860
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinalcord. (2003)
  • 著者名/発表者名: Shibata, T.
  • 雑誌名: Dev.Brain Res. 140 ページ: 263-268
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] High level of mGluR7 in the presynaptic active zones of select popurations of GABAergic terminals innervating interneurones in the rat hippocampus. (2003)
  • 著者名/発表者名: Somogyi, P.
  • 雑誌名: Eur.J.Neurosci. 17 ページ: 2503-2520
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Role of thalamic phospholipase C□□ mediated by metabotropic glutamate receptor type 1 in inflammatory pain. (2003)
  • 著者名/発表者名: Miyata, M.
  • 雑誌名: J.Neurosci. 23 ページ: 8098-8108
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Delphilin : A novel PDZ- and Formin homology (FH)-domain containing protein, which interacts with glutamate receptor δ2 subunit. (2002)
  • 著者名/発表者名: Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S
  • 雑誌名: J Neurosci 22 ページ: 803-814
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Early onset of NMDA receptor GluRε1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. (2002)
  • 著者名/発表者名: Oshima S, Fukaya M, Nagashima M, Shirakawa T, Oguchi H, Watanabe M
  • 雑誌名: Neurosci Res 43 ページ: 239-250
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Requirement for hippocampal CA3 NMDA receptors in associative memory recall. (2002)
  • 著者名/発表者名: Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Jhonston D, Wilson MA, Tonegawa S
  • 雑誌名: Science 297 ページ: 211-218
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluRδ2. (2002)
  • 著者名/発表者名: Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y., Watanabe, M.
  • 雑誌名: J Neurosci 22 ページ: 8487-8503
  • NAID: 120005183161
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Group I mGluR signaling via Gαq/Gα11 secures the induction of long-term potentiation in the hippocampal area CA1. (2002)
  • 著者名/発表者名: Miura M, Watanabe M, Offermanns S, Simon MI, Kano M
  • 雑誌名: J Neurosci 22 ページ: 8379-8390
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Selective Reduction of a PDZ Protein, SAP-97, in the Prefrontal Cortex of Patients with Chronic Schizophrenia. (2002)
  • 著者名/発表者名: Toyooka K, Iritani S, Makifuchi T, Shirakawa O, Kitamura K, Maeda K, Nakamura R, Niizato K, Watanabe M, Kakita A, Takahashi H, Someya T, Nawa N
  • 雑誌名: J Neurochem 83 ページ: 797-806
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. (2002)
  • 著者名/発表者名: Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T
  • 雑誌名: J Cereb Blood Flow Metab 22 ページ: 1327-1335
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells. (2002)
  • 著者名/発表者名: Yamada, K., Watanabe, M.
  • 雑誌名: Anat.Sci.Int. 77 ページ: 94-108
  • NAID: 10011563521
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity. (2002)
  • 著者名/発表者名: Nakamura K, Tanoue K, Satoh T, Takekawa M, Watanabe M, Shima H, Kikuchi K
  • 雑誌名: J Biochem 132 ページ: 463-470
  • NAID: 130003534429
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout. (2002)
  • 著者名/発表者名: Kinoshita M, Kojima S, Sato K, Watanabe M, Urano A, Ito E
  • 雑誌名: Eur J Neurosci 16 ページ: 868-876
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Delphilin : A novel PDZ-and Formin homology (FH)-domain containing protein, which interacts with glutamate receptor □2 subunit. (2002)
  • 著者名/発表者名: Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S
  • 雑誌名: J Neurosci 22 ページ: 803-814
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Early onset of NMDA receptor GluR□1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. (2002)
  • 著者名/発表者名: Oshima S, Fukaya M, Nagashima M, Shirakawa T, Oguchi H, Watanabe M
  • 雑誌名: Neurosci Res 43 ページ: 239-250
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Requirement for hippocampal CA3 NMDA receptors in associative memory recall. (2002)
  • 著者名/発表者名: Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Jhonston D, Wilson MA, Tonegawa S
  • 雑誌名: Science. 297 ページ: 211-218
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluR□2. (2002)
  • 著者名/発表者名: Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y., Watanabe, M.
  • 雑誌名: J Neurosci. 22 ページ: 8487-8503
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Group I mGluR signaling via G□q/G□11 secures the induction of long-term potentiation in the hippocampal area CA1. (2002)
  • 著者名/発表者名: Miura M, Watanabe M, Offermanns S, Simon MI, Kano M
  • 雑誌名: J Neurosci. 22 ページ: 8379-8390
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. (2002)
  • 著者名/発表者名: Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T
  • 雑誌名: J Cereb Blood Flow Metab. 22 ページ: 1327-1335
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout. (2002)
  • 著者名/発表者名: Kinoshita M, Kojima S, Sato K, Watanabe M, Urano A, Ito E
  • 雑誌名: Eur J Neurosci. 16 ページ: 868-876
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The delta2 "glutamate receptor is not activated by glutamate-like ligand.
  • 著者名/発表者名: Hirai, H., Miyazaki, T., Mishina, M., Watanabe.M., Yuzaki, M.
  • 雑誌名: EMBO report. (印刷中)
  • NAID: 130007039063
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Evidence for creatine biosynthesis in Muller glial cells.
  • 著者名/発表者名: Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • 雑誌名: J.Neurochem (印刷中)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons.
  • 著者名/発表者名: Fukaya, M., Hayashi, Y., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. (印刷中)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Control of synaptic connection by glutamate receptor d2 in the mature cerebellum.
  • 著者名/発表者名: Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • 雑誌名: J.Neurosci. (印刷中)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The delta2 "glutamate receptor is not activated by glutamate-likeligand.
  • 著者名/発表者名: Hirai, H., Miyazaki, T., Mishina, M., Watanabe, M., Yuzaki, M.
  • 雑誌名: EMBO report. (in press)
  • NAID: 130007039063
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Evidence for creatine biosynthesis in Muller glial cells.
  • 著者名/発表者名: Nakashima, T, Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • 雑誌名: J.Neurochem. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] NR2-to-NR3B subunit conversion of NMDA receptor in early Postnatal motoneurons.
  • 著者名/発表者名: Fukaya, M., Hayashi, Y., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Control of synaptic connection by glutamate receptor d2 in the mature cerebellum.
  • 著者名/発表者名: Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • 雑誌名: J.Neurosci. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A novel action of stargazin as an enhancer of AMPA receptor activity.
  • 著者名/発表者名: Yamazaki, M., Ohno-Shosaku, T., Fukaya, M., Kano, M., Watanabe, M., Sakimura, K.
  • 雑誌名: Neurosci.Res. 印刷中
  • NAID: 10023901633
• [雑誌論文] Synaptic distribution of the NR1, NR2A, and NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique
  • 著者名/発表者名: Nagy, G.G., Watanabe, M., Fukaya, M., Todd, R.
  • 雑誌名: Eur.J.Neurosci 印刷中
• [雑誌論文] The delta2 "glutamate receptor is not activated by glutamate-like ligand.
  • 著者名/発表者名: Hirai, H., Miyazaki, T., Mishina, M., Watanabe, M., Yuzaki, M.
  • 雑誌名: EMBO report 印刷中
  • NAID: 130007039063
• [雑誌論文] Evidence for creatine biosynthesis in Muller glial cells.
  • 著者名/発表者名: Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • 雑誌名: J.Neurochem 印刷中
• [雑誌論文] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons.
  • 著者名/発表者名: Fukaya, M., Hayashi, Y., Watanabe, M.
  • 雑誌名: Eur.J.Neurosci 印刷中
• [雑誌論文] Control of synaptic connection by glutamate receptor d2 in the mature cerebellum.
  • 著者名/発表者名: Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • 雑誌名: J.Neurosci. 印刷中
• [文献書誌] Sakai, K.: "Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries"J.Neurosci.. 23. 550-560 (2003)
• [文献書誌] Kakizawa, S.: "Effects of Insulin-like Growth Factor I on Climbing Fiber Synapse Elimination during Cerebellar Development"Eur.J.Neurosci. 17. 545-554 (2003)
• [文献書誌] Fukaya, M.: "Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice"Proc.Natl.Acad.Sci.USA. 100. 4855-4860 (2003)
• [文献書誌] Shibata, T.: "Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinal cord"Dev.Brain Res.. 140. 263-268 (2003)
• [文献書誌] Somogyi, P.: "High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurones in the rat hippocampus"Eur.J.Neurosci.. 17. 2503-2520 (2003)
• [文献書誌] Miyazaki, T.: "Developmental switching of vesicular glutamate transporters at parallel fiber-Purkinje cell synapses"Eur.J.Neurosci. 17. 2563-2572 (2003)
• [文献書誌] Sassoe-Pngnetto, M.: "Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb"J.Comp.Neurol.. 463. 237-248 (2003)
• [文献書誌] Miyata, M.: "Role of thalamic phospholipase Cb4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain"J.Neurosci. 23. 8098-8108 (2003)
• [文献書誌] Jourdi, H.: "Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons"Dev.Biol.. 263. 216-230 (2003)
• [文献書誌] Takahashi, Y.: "Autoantibodies to NMDA receptor in patients with chronic formsof epilepsia partialis continua"Neurol.. 61. 891-896 (2003)
• [文献書誌] Yamashita, N.: "Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneuriai fibroblasts along sciatic nerves and its upregulation after crush injury"Arch.Histol.Cytol.. (印刷中).
• [文献書誌] Hama, K.: "Lysophosphatidic acid and autaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1"J.Biol.Chem.. (印刷中).
• [文献書誌] Ferraguti, F.: "Immunolocalization of metabotropic glutamate receptor 1a (mGluR1a) in distinct classes of interneuron in the CA1 region of the rat hippocampus"Hippocampus. (印刷中).
• [文献書誌] Jourdi, H.: "Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-accociated PDZ proteins in developing cortical neurons"Dev Biol. (印刷中).
• [文献書誌] Kinoshita, N.: "Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes"Genes Cells. (印刷中).
• [文献書誌] Miyazaki, M.: "P/Q-type Ca^<2+> channel α1A regulates synaptic competition on developing cerebellar Purkinje cells"J.Neurosci.. (印刷中).
• [文献書誌] Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S: "Delphilin : A novel PDZ-and Formin homology (FH)-domain containing. protein, which interacts with glutamate receptor δ2 subunit"J Neurosci. 22. 803-814 (2002)
• [文献書誌] Oshima S, Fukaya M, Nagashima M, Shirakawa T, Oguchi H, Watanabe M: "Early onset of NMDA receptor GluRε1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus"Neurosci Res. 43. 239-250 (2002)
• [文献書誌] Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Jhonston D, Wilson MA, Tonegawa S: "Reauirement for hippocampal CA3 NMDA receptors in associative memory recall"Science. 297. 211-218 (2002)
• [文献書誌] Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y., Watanabe.M.: "Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluRδ2"J Neurosci. 22. 8487-8503 (2002)
• [文献書誌] Miura M, Watanabe M, Offermanns S, Simon MI, Kano M: "Group I mGluR signaling via Gαq/Gα11 secures the induction of long-term potentiation in the hippocampal area CA1"J Neurosci. 22. 8379-8390 (2002)
• [文献書誌] Toyooka K, Iritani S, Makifuchi T.Shirakawa O, Kitamura K, Maeda K, Nakamura R, Niizato K, Watanabe M, Kakita A, Takahashi H, Someya T, Nawa N: "Selective Reduction of a PDZ Protein, SAP-97, in the Prefrontal Cortex of Patients with Chronic Schizophrenia"J Neurochem. 83. 797-806 (2002)
• [文献書誌] Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T: "The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain"J Cereb Blood Flow Metab. 22. 1327-1335 (2002)
• [文献書誌] Nakamura K, Tanoue K, Satoh T.Takekawa M, Watanabe M, Shima H, Kikuchi K: "A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity"J Biochem. 132. 463-470 (2002)
• [文献書誌] Kinoshita M, Kojima S, Sato K, Watanabe M, Urano A, Ito E: "A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity"J Biochem. 132. 463-470 (2002)
• [文献書誌] Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M: "Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries"J Neurosci. 23. 550-560 (2003)
• [文献書誌] Kakizawa S, Yamada K, Watanabe M, Kano M: "Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development"Eur J Neurosci. (印刷中).
• [文献書誌] Fukaya M, kato A, Lovett C, Tonegawa S, Watanabe M: "Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice"Proc Natl Acad Sci USA. (印刷中).