性分化異常症および生殖機能障害の包括的遺伝子変異および多型解析とその臨床応用

• 研究課題/領域番号: 16086215
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 国立成育医療センター(研究所)
• 研究代表者: 緒方 勤 国立成育医療センター研究所, 小児思春期発育研究部, 部長 (40169173)
• 研究分担者: 勝又 規行 国立成育医療センター研究所, 小児思春期発育研究部, 室長 (10260340) ; 深見 真紀 国立成育医療センター研究所, 小児思春期発育研究部, 室長 (40265872) ; 佐藤 直子 国立成育医療センター研究所, 小児思春期発育研究部, 研究員 (10383069)
• 研究期間 (年度): 2004 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 87,000千円 (直接経費: 87,000千円); 2008年度: 17,400千円 (直接経費: 17,400千円); 2007年度: 17,400千円 (直接経費: 17,400千円); 2006年度: 17,400千円 (直接経費: 17,400千円); 2005年度: 17,400千円 (直接経費: 17,400千円); 2004年度: 17,400千円 (直接経費: 17,400千円)
• キーワード: 性分化異常症 / 単一遺伝子疾患 / 多因子疾患 / ヒト遺伝疾患 / 内分泌撹乱物質 / 精巣形成不全 / 新規性分化異常症責任遺伝子 / Notchシグナル伝達経路 / エストロゲン受容体α遺伝子 / Nothシグナル伝達経路 / Ad4BP / SF1 / POR

研究概要

単一遺伝子疾患としての性分化異常症:新規尿道下裂責任遺伝子MAMLD1の同定と機能解析、胎児期・乳児期特異的男性ホルモン産生経路backdoor pathway の同定、第14 染色体父性ダイソミーと母性ダイソミー表現型を招く(エピ)遺伝的機序の解明、AD4BP/SF1 遺伝子上昇の同定と機能解析、ゴナドトロピン分泌不全症の遺伝的機序の解明を行った。多因子疾患としての性分化異常症:内分泌撹乱化学物質感受性ハプロタイプの同定、外陰部異常症発症感受性多型の同定を行った。

研究成果

• [雑誌論文] CHD7 mutations in patients initially diagnosed with Kallmann syndrome - the clinical overlap with CHARGE syndrome (2009)
  • 著者名/発表者名: Ogata T(計10 名中4 番目), Sato N(計10名中5 番目), Claahsen-van der Grinten HL, van der Donk K, Seminara S, Bergman JE, Brunner HG, Crowley WF Jr, Hoefsloot LH
  • 雑誌名: Clinical Genetics 75 (1) ページ: 65-71
• [雑誌論文] Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns (2009)
  • 著者名/発表者名: Ogata T(計9 名中最終)
  • 雑誌名: Fertility and Sterility 91 (2) ページ: 649-652
• [雑誌論文] MAMLD1(CXorf6) is a new gene for hypospadias (2008)
  • 著者名/発表者名: Ogata T, Fukami M, Wada Y
  • 雑誌名: Clinical Pediatric Endocrinology 17 (4) ページ: 87-93
  • NAID: 10031199580
• [雑誌論文] Molecular mechanisms leading to the phenotypic development in paternal and maternal uniparental disomy for chromosome 14 (2008)
  • 著者名/発表者名: Ogata T, Kagami M
  • 雑誌名: Clinical Pediatric Endocrinology 17 (4) ページ: 103-111
  • NAID: 10031199582
• [雑誌論文] Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14 (2008)
  • 著者名/発表者名: Ogata T, Kagami M, Ferguson-Smith AC
  • 雑誌名: Epigenetics 3 (4) ページ: 181-187
• [雑誌論文] MAMLD1(CXorf6): a new gene for hypospadias (2008)
  • 著者名/発表者名: Ogata T, Wada Y, Fukami M
  • 雑誌名: Sexual Development 2 (4-5) ページ: 244-250
• [雑誌論文] Genomic imprinting at the mammaliad Dlk1-Dio3 domain (2008)
  • 著者名/発表者名: da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC
  • 雑誌名: Trends in Genetics 24 (6) ページ: 306-16
• [雑誌論文] Monozygotic female twins discordant for Silver-Russell syndrome and hypomethylation of the H19-DMR (2008)
  • 著者名/発表者名: Yamazawa K, Kagami M, Fukami M, Ogata T
  • 雑誌名: Journal of Human Genetics 53 (10) ページ: 950-955
  • NAID: 10022603248
• [雑誌論文] Placentomegaly in paternal uniparental disomy for human chromosome 14 (2008)
  • 著者名/発表者名: Kagami M, Yamazawa K, Matsubara K, Matsuo N, Ogata T
  • 雑誌名: Placenta 29 (8) ページ: 760-761
• [雑誌論文] OTX2 Mutation in a patient with anophthalmia, short stature, and partial GH deficiency: functional studies using the IRBP, HESX1, and POU1F1 promoters (2008)
  • 著者名/発表者名: Dateki S, Fukami M, Sato N, Muroya K, Adachi M, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 93 (10) ページ: 3697-702
• [雑誌論文] Molecular andclinical findings and their correlations in Silver-Russell syndrome: implications for the critical role of IGF2 as the growth determinant and the differential imprinting regulation of the IGF2-H19 domain in bodies and placentas (2008)
  • 著者名/発表者名: Ogata T(計15 名中最終)
  • 雑誌名: Journal of Molecular Medicine 86 (10) ページ: 1171-1181
• [雑誌論文] Epimutation (hypomethylation) affecting the chromosome 14q32.2 imprinted region in a girl with upd(14)mat-like phenotype (2008)
  • 著者名/発表者名: Ogata T(計5 名中2 番目)
  • 雑誌名: European Journal of Human Genetics 16 (8) ページ: 1019-1023
• [雑誌論文] CXorf6 (MAMR1: mastermind-related 1) transactivates the Hes3 promoter, augments testosterone production, and contains the target sequence for SF-1 (2008)
  • 著者名/発表者名: Fukami M(筆頭), Ogata T(計10 名中最終)
  • 雑誌名: Journal of Biological Chemistry 283 (9) ページ: 5525-5532
• [雑誌論文] Essential role of Rtl1 in the feto-maternal interface of mouse placenta (2008)
  • 著者名/発表者名: Ogata T(計14 名中11 番目)
  • 雑誌名: Nature Genetics 40 (2) ページ: 243-248
• [雑誌論文] Deletions and epimutations affecting the human chromosome 14q32.2 imprinted region: implications for the phenotypic development in paternal and maternal uniparental disomy for chromosome 14 (2008)
  • 著者名/発表者名: Ogata T(計24 名中最終)
  • 雑誌名: Nature Genetics 40 (2) ページ: 237-242
• [雑誌論文] Placental hypoplasia in maternal uniparental disomy for chromosome 7 (2008)
  • 著者名/発表者名: Ogata T(計5 名中最終)
  • 雑誌名: Americam Journal of Medical Gneteics A 146 (4) ページ: 514-516
• [雑誌論文] Abnormal urethra formation as a model for hypospadias of the split-hand-foot malformation (SHFM) (2008)
  • 著者名/発表者名: Ogata T(計12 名中3 番目)
  • 雑誌名: European Journal of Human Genetics 16 (1) ページ: 36-44
• [雑誌論文] CXorf6(MAMR1:mastermind-related 1) transactivates the Hes3 promoter, augments testosterone production, and contains the target sequence for SF-1 (2008)
  • 著者名/発表者名: Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T
  • 雑誌名: Journal of Biological Chemistry 283(9) ページ: 5525-5532
  • 査読あり
• [雑誌論文] OTX2 Mutation in a patient with anophthalmia, short stature, and partial GH deficiency: functional studies using the IRBP, HESX1, and POU1F1 promoters (2008)
  • 著者名/発表者名: Dateki S, Fukami M, Sato N, Muroya K, Adachi M, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology & Metabolism 9号(10 ページ: 3697-702
  • 査読あり
• [雑誌論文] Deletions and epunutations affecting the human chromosome 14q32.2 imprinted region: implications for the phenotypic development in paternal and maternal uniparental disomy for chromosome 14 (2008)
  • 著者名/発表者名: Kagami M, Sekita Y, Nishimura G, Irie M, Kaio F, Okada M,Yamamori S, Kishimoto H, Nakayama M, Tanaka Y, Matsuoka K, Takahashi T, Noguchi M, Tanaka Y, Masumoto K, Utsunomiya T, Kouzan H, Komatsu Y. Ohashi H, Kurosawa K, Kosaki K, Ferguson-Smith AC, Ishino F, Ogata T.
  • 雑誌名: Nature Genetics 402 ページ: 237-242
  • 査読あり
• [雑誌論文] CXorf6(MAMR1:mastemind-related1)transactivates the Hes3 promoter,augments testosterone production,and contains the target sequence for SF-1 (2008)
  • 著者名/発表者名: Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Lapgrtc J, Kitagawa M, Ogata T
  • 雑誌名: Journal of Biological Chemistry 283(9) ページ: 5525-5532
  • 査読あり
• [雑誌論文] Haplotype analysis of the estrogen receptor α gene in male genital and reproductive abnormalities (2007)
  • 著者名/発表者名: Ogata T(計11 名中最終)
  • 雑誌名: Human Reproduction 22(5) ページ: 1279-1284
• [雑誌論文] Hypogonadotropic hypogonadism in an adult female with heterozygous hypomorphic mutation of SOX2 (2007)
  • 著者名/発表者名: Sato N(筆頭), Ogata T(計7 名中最終)
  • 雑誌名: European Journal of Endocrinology 156 (2) ページ: 167-171
• [雑誌論文] Haplotype analysis of the estrogen receptor a gene in male genital and reproductive abnormalities (2007)
  • 著者名/発表者名: Watanabe M, Yoshida R, Ueoka K, Aoki K, Sasagawa T, Hasegawa T, Sueoka K, Kamistsuji S, Kamatani N, Yoshimura Y, Ogata T.
  • 雑誌名: Human Reproduction 22(5) ページ: 1279-1284
  • 査読あり
• [雑誌論文] CXorf6 is a causative gene for hypospadias (2006)
  • 著者名/発表者名: Fukami M(筆頭), Ogata T(計12 名中最終)
  • 雑誌名: Nature Genetics 38 (12) ページ: 1369-1371
• [雑誌論文] Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism (2006)
  • 著者名/発表者名: gata T(計 7 名中最終)
  • 雑誌名: Hormone Research 67 (2) ページ: 73-76
• [雑誌論文] Kallmann syndrome phenotype in a female patient with CHARGE syndrome and CHD7 mutation (2006)
  • 著者名/発表者名: Ogata T(計6 名中筆頭)
  • 雑誌名: Endocrine Journal 53 (6) ページ: 741-743
  • NAID: 10020612413
• [雑誌論文] Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone (2006)
  • 著者名/発表者名: Fukami M(計10 名中9 番目)、 Ogata T(計10 名中最終)
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 91 (7) ページ: 2643-2649
• [雑誌論文] Somatic and germline mutations of the fibroblast growth factor receptor 1 gene in a mother and the son: implication for apparently mutation negative Kallmann syndrome (2006)
  • 著者名/発表者名: Sato N, Ohyama K, Fukami M, Okada M, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 91 (4) ページ: 1415-1418
• [雑誌論文] Cytochrome P450 oxidoreductase deficiency in three patients initially regarded as having 21-hydroxylase deficiency and/or aromatase deficiency (2006)
  • 著者名/発表者名: Fukami M, Hasegawa T, Horikawa R, Ohashi T, Nishimura G, Homma K, Ogata T
  • 雑誌名: Pediatric Research 59 (2) ページ: 276-280
• [雑誌論文] Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1 (2006)
  • 著者名/発表者名: Wada Y, Okada M, Fukami M, Sasagawa I, Ogata T
  • 雑誌名: Fertility and Sterility 85 (3) ページ: 787-790
• [雑誌論文] CXorf6 is a causative gene for hypospadias (2006)
  • 著者名/発表者名: Fukami M, Ogata T, et al.
  • 雑誌名: Nature Genetics 38(12) ページ: 1369-1371
• [雑誌論文] Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism (2006)
  • 著者名/発表者名: Ogata T, et al.
  • 雑誌名: Hormone Research 67(2) ページ: 73-76
• [雑誌論文] Kallmann syndrome phenotype in a female patient with CHARGE syndrome and CHD7 mutation (2006)
  • 著者名/発表者名: Ogata T, et al.
  • 雑誌名: Endocrine Journal 53(6) ページ: 741-743
  • NAID: 10020612413
• [雑誌論文] Cytochrome P450 oxidoreductase deficiency in three patients initially regarded as having 21-hydroxylase deficiency and/or aromatase deficiency (2006)
  • 著者名/発表者名: Fukami M, Hasegawa T, Horikawa R, Ohashi T, Nishimura G, Homma K, Ogata T
  • 雑誌名: Pediatric Research 59(2) ページ: 276-280
• [雑誌論文] Somatic and germline mutations of the fibroblast growth factor receptor 1 gene in a mother and the son : implication for apparently mutation negative Kallmann syndrome (2006)
  • 著者名/発表者名: Sato N, Ohyama K, Fukami M, Okada M, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 91(4) ページ: 1415-1418
• [雑誌論文] Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1 (2006)
  • 著者名/発表者名: Wada Y, Okada M, Fukami M, Sasagawa I, Ogata T
  • 雑誌名: Fertility and Sterility 85(3) ページ: 787-790
• [雑誌論文] Association of common LH variant with hyperfunctional promoter in a Japanese infertile woman (2005)
  • 著者名/発表者名: Ogata T(計5 名中2 番目)
  • 雑誌名: Endocrine Journal 52 (6) ページ: 781-784
  • NAID: 10016916602
• [雑誌論文] Association of severe micropenis with Gly146Ala polymorphism in the gene for steroidogenic factor-1 (2005)
  • 著者名/発表者名: Wada Y, Okada M, Hasegawa T, Ogata T
  • 雑誌名: Endocrine Journal 52(4) ページ: 445-448
  • NAID: 130004769945
• [雑誌論文] Segmental and full paternal isodisomy for chromosome 14 in three patients: localization of the critical region and implication for the clinical features. (2005)
  • 著者名/発表者名: Ogata T(計9 名中最終)
  • 雑誌名: American Journal of Medical Genetics A 138 (2) ページ: 127-132
• [雑誌論文] Gonadotropin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: report of three families (2005)
  • 著者名/発表者名: Sato N, Hasegawa T, Hori N, Fukami M, Yoshimura Y, Ogata T
  • 雑誌名: Human Reproduction 20 (8) ページ: 2173-2178
• [雑誌論文] Association of cryptorchidism with a specific haplotype of the estrogen receptor α gene: implication for the susceptibility to estrogenic environmental endocrine disruptors (2005)
  • 著者名/発表者名: Yoshida R, Fukami M, Sasagawa I, Hasegawa T, Kamatani N, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 90(8) ページ: 4716-4721
• [雑誌論文] Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling (2005)
  • 著者名/発表者名: Ogata T(計7 名中最終)
  • 雑誌名: Endocrine Journal 52 (1) ページ: 83-88
  • NAID: 10014483728
• [雑誌論文] Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients (2005)
  • 著者名/発表者名: Fukami M(筆頭), Ogata T(計16 名中最終)
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 90 ページ: 414-426
• [雑誌論文] Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis : molecular and clinical studies in 10 patients (2005)
  • 著者名/発表者名: Fukami M, Ogata T, et al.
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 90(1) ページ: 414-426
• [雑誌論文] Association of cryptorchidism with a specific haplotype of the estrogen receptor α gene : implication for the susceptibility to estrogenic environmental endocrine disruptors (2005)
  • 著者名/発表者名: Yoshida R, Fukami M, Sasagawa I, Hasegawa T, Kamatani N, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 90(8) ページ: 4716-4721
• [雑誌論文] Gonadotropin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1 : report of three families (2005)
  • 著者名/発表者名: Sato N, Hasegawa T, Hori N, Fukami M, Yoshimura Y, Ogata T
  • 雑誌名: Human Reproduction 120(8) ページ: 2173-2178
• [雑誌論文] Testicular dysgenesis without adrenal insufficiency in a 46,XY patient with a heterozygous inactive mutation of steroidogenic factor-1 (2004)
  • 著者名/発表者名: Hasegawa T, Fukami M, Sato N, Sasaki G, Fukutani K, Morohashi K, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 89 ページ: 5930-5935
• [雑誌論文] Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins (2004)
  • 著者名/発表者名: Ogata T(67 名中最終)
  • 雑誌名: Fertility and Sterility 82 ページ: 1067-1071
• [雑誌論文] Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in 53 Japanese boys with micropenis (2004)
  • 著者名/発表者名: Ogata T(計7 名中最終)
  • 雑誌名: Journal of Urology 172 (1) ページ: 319-324
• [雑誌論文] Genitourinary phenotype in XX patients with distal 9p monosomy (2004)
  • 著者名/発表者名: Ogata T(計7 名中最終)
  • 雑誌名: Molecular Genetics and Metabolism 82 (2) ページ: 173-179
• [雑誌論文] Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients (2004)
  • 著者名/発表者名: Sato N(筆頭), Ogata T(計19 名中最終)
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 89 (3) ページ: 1079-1088
• [雑誌論文] Testicular dysgenesis without adrenal insufficiency in a 46, XY patient with a heterozygous inactive mutation of steroidogenic factor-1 (2004)
  • 著者名/発表者名: Hasegawa T, Fukami_M, Sato N, Sasaki G, Fukutani K, Morohashi K, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 89(12) ページ: 5930-5935
• [雑誌論文] Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene : implication for the susceptibility to dioxins (2004)
  • 著者名/発表者名: Watanabe M, Sueoka K, Sasagawa I, Nakabayashi A, Yoshimura Y, Ogata T
  • 雑誌名: Fertility and Sterility 82(suppl 3) ページ: 1067-1071
• [雑誌論文] Genitourinary phenotype in XX patients with distal 9p monosomy (2004)
  • 著者名/発表者名: Fujimoto Y, Okuyama T, Iijima M, Tanaka T, Horikawa R, Yamada K, Ogata T
  • 雑誌名: Molecular Genetics and Metabolism 82(2) ページ: 173-179
• [雑誌論文] Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients (2004)
  • 著者名/発表者名: Sato N, Katsumata N, Ogata T, et al.
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism 89(3) ページ: 1079-1088
• [雑誌論文] MAMLD1(CXorf6): a new gene involved in hypospadias
  • 著者名/発表者名: Ogata T, Laporte J, Fukami M
  • 雑誌名: Hormone Research (in press)
• [雑誌論文] Cytochrome P450 oxidoreductase deficiency: identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients
  • 著者名/発表者名: Fukami M(筆頭), Ogata T(計21 名中最終)
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism (in press)
• [雑誌論文] Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns
  • 著者名/発表者名: Sugawa F, Wada Y, Okada M, Maruyama T, Uchida H, Arase T, Hamada N, Ishizuka B, Ogata T
  • 雑誌名: Fertility and Sterility In press
  • 査読あり
• [雑誌論文] Cytochrome P450 oxidoreductase deficiency in three patients initially regarded as having 21-hydroxylase deficiency and/or aromatase deficiency
  • 著者名/発表者名: Fukami M, Hasegawa T, Horikawa R, Ohashi T, Nishimura G, Homma K, Ogata T
  • 雑誌名: Pediatric Research (In press)
• [雑誌論文] Somatic and germline mutations of the fibroblast growth factor receptor 1 gene in a mother and the son : implication for apparently mutation negative Kallmann syndrome
  • 著者名/発表者名: Sato N, Ohyama K, Fukami M, Okada M, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism (In press)
• [雑誌論文] Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1
  • 著者名/発表者名: Wada Y, Okada M, Fukami M, Sasagawa I, Ogata T
  • 雑誌名: Fertility and Sterility (In press)
• [雑誌論文] Association of cryptorchidism with a specific haplotype of the estrogen receptor a gene implication for the susceptibility to estrogenic environmental endocrine disruptors
  • 著者名/発表者名: Yoshida R, Fukami M, Sasagawa I, Hasegawa T, Kamatani N, Ogata T
  • 雑誌名: Journal of Clinical Endocrinology and Metabolism In press
• [学会発表] Disorders of Sex Development: New Gene and New Mechanism (2008)
  • 著者名/発表者名: Ogata T
  • 学会等名: The 47th Meeting of European Society for Paediatric Endocnnology
  • 発表場所: Istanbul
• [学会発表] The novel hypospadias gene CXorf6 transactivates the promoter of a non-canonical Notch target gene Hes3 and contains the tazget sequence for SF-1 (2007)
  • 著者名/発表者名: Fukami M, Morohashi K, Wada Y, Okada M, Iaporte J, Kitagawa M, Ogata T
  • 学会等名: The Endocrine Society's 89th Annual Meeting
  • 発表場所: トロント
• [産業財産権] 尿道下裂および他のストロゲン依存性疾患発症のリスクとエストロゲン製剤効果の評価法としてのエストロゲン受容体α 遺伝子のSNP解析法 (2006)
  • 発明者名: 緒方勤
  • 権利者名: 国立成育医療センター
  • 出願年月日: 2006-04-19
  • 外国
• [産業財産権] 新規性分化異常症責任遺伝子MHX(Cxor6)によるNotch リポーター遺伝子転写活性化の同定 (2006)
  • 発明者名: 緒方勤
  • 権利者名: 国立成育医療センター
  • 出願年月日: 2006-04-07
• [産業財産権] エストロゲン受容体α遺伝子におけるハプロタイプブロックの同定および特定ハプロタイプによる男児外陰部異常症発症感受性亢進 (2004)
  • 発明者名: 緒方勤
  • 権利者名: 国立成育医療センター
  • 出願年月日: 2004-08-30