突然変異と細胞がん化の原因となる放射線誘発長寿命ラジカルの性質

• 研究課題/領域番号: 16101002
• 研究種目: 基盤研究(S)
• 配分区分: 補助金
• 研究分野: 放射線・化学物質影響科学
• 研究機関: 京都大学
• 研究代表者: 渡邉 正己 京都大学, 原子炉実験所, 教授 (20111768)
• 研究分担者: 鈴木 啓司 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (00196809) ; 児玉 靖司 大阪府立大学, 産学官連携機構, 教授 (00195744) ; 熊谷 純 名古屋大学, 大学院・工学研究科, 准教授 (20303662) ; 島田 義也 放射線医学総合研究所, プロジェクトリーダー (10201550)
• 研究期間 (年度): 2004 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 101,270千円 (直接経費: 77,900千円、間接経費: 23,370千円); 2008年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2007年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2006年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2005年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2004年度: 26,390千円 (直接経費: 20,300千円、間接経費: 6,090千円)
• キーワード: 放射線 / 突然変異 / 細胞がん化 / 長寿命ラジカル / 放射線発がん / 自然発がん / 染色体異数化 / ミトコンドリア / バイスタンダー効果 / ビタミンC / 細胞内酸化ラジカル / 染色体三倍体 / 細胞老化 / セミキセノンラジカル / 遺伝的不安定性 / 遅延型影響 / 情報伝達因子 / ESR解析 / システインラジカル / エピガロカテキン / X線 / 遠紫外線(UV-B) / 照射後処理

研究概要

放射線を照射された細胞に複数の長寿命ラジカル(LLR^*)が誘導されることがわかった。その代表的なものが、システイン残基を持つタンパク質に生じたスルフィニルラジカル(R-CH2-SO・)およびセミキセノンラジカルである。これらは、放射線被ばく後、1時間~10時間の間にミトコンドリアで誘導され、細胞内の高分子タンパクをゆっくりラジカル化することによって、細胞の様々な高度機能障害を生じさせることが明らかとなった。

研究成果

• [雑誌論文] Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene (2009)
  • 著者名/発表者名: Ariyoshi K, Suzuki K, Goto M, Oshimura M, Ishizaki K, Watanabe M, Kodama S
  • 雑誌名: J. Radiat. Res. (in press)
  • NAID: 10025911840
• [雑誌論文] Evaluation of the potential of hexamethylenetetramineas a combined agent with gamma-ray irradiation and cisplatin treatment in vivo, compared with tirapazamine (2009)
  • 著者名/発表者名: Masunaga S, Tano K, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K, Nakamura J
  • 雑誌名: British J Radiol Jan 19(Epub ahead of print)
• [雑誌論文] Induction of DNA double-strand breaks and cellular migration through bystander effects in cells irradiated with the slit-type microplanar beam of the SPring-8 synchrotron (2009)
  • 著者名/発表者名: Kashino G, Kondoh T, Nariyama N, Umetani K, Ohigashi T, Shinohara K, Kurihara A, Fukumoto M, Tanaka H, Maruhashi A, Suzuki S, Kinashi Y, Liu Yong, Masunaga S,Watanabe M, Ono K
  • 雑誌名: Intern J Radiat Oncol Biol Phys (in press)
• [雑誌論文] Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells (2009)
  • 著者名/発表者名: Masunaga S, Kono K, Nakamura J, Tano K, Yoshida Y, Watanabe M, Kashino G, Suzuki M, Kinashi Y, and Ono K
  • 雑誌名: Oncology Report 21 ページ: 1307-1312
• [雑誌論文] The contribution of radiation-induced large deletion of the genome to chromosomal instability (2009)
  • 著者名/発表者名: Toyokuni H, Maruo A, Suzuki K, Watanabe M
  • 雑誌名: Radiat Res 171 ページ: 198-203
• [雑誌論文] Intervention of oxygen-control ability to radiation sensitivity, cell aging and cell transformation (2009)
  • 著者名/発表者名: Yoshii H, Watanabe M
  • 雑誌名: J RadiatRes (Tokyo) 50 ページ: 127-137
  • NAID: 10025911412
• [雑誌論文] Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities (2009)
  • 著者名/発表者名: Yoshikawa T, Kashino G, Ono K, Watanabe M
  • 雑誌名: J Radiat Res(Tokyo) 50 ページ: 151-160
  • NAID: 10025911507
• [雑誌論文] Intervention of oxygen-control ability to radiation sensitivity, cell aging and cell transformation. (2009)
  • 著者名/発表者名: Yoshii H, Watanabe M
  • 雑誌名: J Radiat Res (Tokyo) 50 ページ: 127-137
  • NAID: 10025911412
  • 査読あり
• [雑誌論文] Different involvement of radical species in irradiated and bystander cells. (2009)
  • 著者名/発表者名: Harada T, Kashino G, Suzuki K, Matsuda N, Kodama S, Watanabe M
  • 雑誌名: Int J Radiat Biol 379 ページ: 809-814
  • 査読あり
• [雑誌論文] Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities. (2009)
  • 著者名/発表者名: Yoshikawa T, Kashino G, Ono K, Watanabe M
  • 雑誌名: J Radiat Res(Tokyo) 50 ページ: 151-160
  • NAID: 10025911507
  • 査読あり
• [雑誌論文] The contribution of radiation-induced large deletion of the genome to chromosomal instability. (2009)
  • 著者名/発表者名: Hamamoto T, Suzuki K, Yamauchi M, Kodama S, Sasaki H, Watanabe M
  • 雑誌名: Int J Hyperthermia 24 ページ: 415-425
  • 査読あり
• [雑誌論文] Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing (2009)
  • 著者名/発表者名: Ariyoshi K, Suzuki K, Goto M, Oshimura M, Ishizaki K, Watanabe M
  • 雑誌名: J Radiat Res(Tokyo) (in press)
  • 査読あり
• [雑誌論文] The contribution of radiation-induced large deletion of the genome to chromosomal instability. (2009)
  • 著者名/発表者名: Kashino G, Kondoh T, Watanabe M, ほか3名
  • 雑誌名: Intern J Radiat Oncol Biol Phys (in press)
  • 査読あり
• [雑誌論文] Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling. (2009)
  • 著者名/発表者名: Yamauchi M, Oka Y, Kodama S, Watanabe M, Suzuki K, ほか5名
  • 雑誌名: DNA Repair(Amst) 7 ページ: 405-417
  • NAID: 120006983929
  • 査読あり
• [雑誌論文] Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism (2008)
  • 著者名/発表者名: Hori M, Suzuki K, Udono MU, Yamauchi M,Mine M, Watanabe M, Kondo S, Hozumi Y
  • 雑誌名: Arch Dermatol Res Nov 14
• [雑誌論文] p53 status-dependent sensitization of humantumour cells to hyperthermia by plant flavonol (2008)
  • 著者名/発表者名: Hamamoto T, Suzuki K, Yamauchi M,Kodama S, Sasaki H, Watanabe M
  • 雑誌名: Int J Hyperthermia 24 ページ: 415-425
• [雑誌論文] Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling (2008)
  • 著者名/発表者名: Yamauchi M, Oka Y, Yamamoto M, Niimura K, Uchida M, Kodama S, Watanabe M, Sekine I, Yamashita S, Suzuki K
  • 雑誌名: DNA Repair(Amst) 7 ページ: 405-417
  • NAID: 120006983929
• [雑誌論文] Different involvement of radical species in irradiated and bystander cells (2008)
  • 著者名/発表者名: Harada T, Kashino G, Suzuki K, Matsuda N, Kodama S, Watanabe M
  • 雑誌名: Int J Radiat Biol 84 ページ: 809-814
• [雑誌論文] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2 (2008)
  • 著者名/発表者名: Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A, Akita M, Tada S, Watanabe M, Seki M, Enomoto T
  • 雑誌名: Biochem Biophys Res Commun 379 ページ: 233-238
• [雑誌論文] Alteration of p53-binding protein 1 expression during skin carcinogenesis : association with genomic instaibility (2008)
  • 著者名/発表者名: Naruke Y, Nakashima M, Suzuki K, Matsuu-Matsuyama M, Shichijo K, Kondo H, Sekine I
  • 雑誌名: Cancer Sci 99(5) ページ: 946-951
• [雑誌論文] Foci formation of p53-binding protein 1 in thyroid tumors:activation of genomic instaibility duringthyroid carcinogenesis (2008)
  • 著者名/発表者名: Nakashima M, Suzuki K, Meirmanov S, Naruke Y, Matsuu-Matsuyama M, Shichijo K, Saenko V, Kondo H, Hayashi T, Ito M,Yamashita S, Sekine I
  • 雑誌名: Int J Cancer 122(5) ページ: 1082-1088
• [雑誌論文] Generation and characterization of cells that can be conditionally depleted of mitochondrial S0D2. (2008)
  • 著者名/発表者名: Takada S, Inoue E, Tano K, Watanabe M, Enomoto T, ほか6名
  • 雑誌名: Biochem Biophys Res Commun 379 ページ: 233-238
  • 査読あり
• [雑誌論文] Transmission of Genomic Instability from a Single Irradiated Human Chromosome to the Progeny of Unirradiated Cells. (2007)
  • 著者名/発表者名: Mukaida N, Kodama S, Suzuki K, Oshimura M, Watanabe M
  • 雑誌名: Radiation Res 167 ページ: 675-681
  • 査読あり
• [雑誌論文] Correlation of malignant phenotypes of human tumour cell lines with augmented expression of HSP72 protein measured by laser scanning cytometry. (2007)
  • 著者名/発表者名: Hamamoto, T, Suzuki, K, Kodama S, Sasaki, H, Abe, K, Hayashi, T, Watanabe, M
  • 雑誌名: Int J Hyper 23 ページ: 363-370
  • 査読あり
• [雑誌論文] Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells. (2007)
  • 著者名/発表者名: Kashino G, Prise KM, Suzuki K, Matsuda N, Kodama S, Suzuki M, Nagata K, Kinashi Y, Masunaga S, Ono K, Watanabe M
  • 雑誌名: J Radiat Res 48 ページ: 327-333
  • NAID: 110006343945
  • 査読あり
• [雑誌論文] Radiation induced bystander sugnals are independent of DNA damage and DNA repair capacity of the irradiated cells. (2007)
  • 著者名/発表者名: Kashino G, Suzuki K, Matsuda N, Kodama S, Ono K, Watanabe M, Rrise KM
  • 雑誌名: Mutat. Res. (in press)
• [雑誌論文] Transmission of Genomic Instability from a Single Irradiated Human Chromosome to the Progeny of Unirradiated Cells (2007)
  • 著者名/発表者名: Mukaida N, Kodama S, Suzuki K, Oshimura M, Watanabe M
  • 雑誌名: Radiat. Res. (in press)
• [雑誌論文] Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft X rays : evidence for chromatin movement during repair (2006)
  • 著者名/発表者名: Hamada N, Schettino G, Kashino G, Vaid M, Suzuki K, Kodama S, Vojnovic B, Folkard M, Watanabe M, Michael BD, Prise KM
  • 雑誌名: Radiat. Res. 166 ページ: 31-38
• [雑誌論文] Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation (2006)
  • 著者名/発表者名: Suzuki M, Suzuki K, Kodama S, Watanabe M
  • 雑誌名: Radiat. Res. 165(3) ページ: 265-276
• [雑誌論文] Delayed activation of DNA damage checkpoint and radiation-induced genomic instability (2006)
  • 著者名/発表者名: Suzuki K, Ojima M, Kodama S, Watanabe M
  • 雑誌名: Mutat. Res. 597 ページ: 73-77
• [雑誌論文] Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest (2006)
  • 著者名/発表者名: Suzuki M, Suzuki K, Kodama S, Watanabe M
  • 雑誌名: Biochem. Biophys. Res. Commun. 340(1) ページ: 145-150
• [雑誌論文] The higher lethality of UVB radiation to cultured human cells is associated with the specific activation of a DNA damage-independent signaling pathway. (2006)
  • 著者名/発表者名: Horikawa-Miura, M., Yoshida, M., Okumura, Y., Mori, T., Watanabe, M.
  • 雑誌名: Radiat.Res. (in press)
• [雑誌論文] Cellular and molecular effects for mutation induction in normal human cells irradiated with accelerated neon ions. (2006)
  • 著者名/発表者名: Suzuki M, Tsuruoka C, Kanai T, Kato T, Yatagai F, Watanabe, M.
  • 雑誌名: Mutat Res. 594 ページ: 86-92
• [雑誌論文] Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft X-rays : Evidence for chromatin movement during repair. (2006)
  • 著者名/発表者名: Hamada, N., Schettino, G., Kashino, G., Vaid, M., Suzuki, K., Kodoma, S., Vojnovic, B., Folkard, M., Watanabe, M., Michael B.
  • 雑誌名: Radiat.Res. (In press)
• [雑誌論文] Qualitative and quantitative analysis of phosphorylated ATM foci induced by low dose ionizing radiation. (2006)
  • 著者名/発表者名: Suzuki, K., Okada, Yamauchi, M., Oka, Y., Kodama, S., Watanabe, M.
  • 雑誌名: Radiat.Res. (In press)
• [雑誌論文] Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation (2006)
  • 著者名/発表者名: Suzuki, M., Suzuki, K., Kodama, S., Watanabe, M.
  • 雑誌名: Radiat.Res. 165・3 ページ: 269-276
• [雑誌論文] Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. (2005)
  • 著者名/発表者名: Kashino G, Prise KM, Schettino G, Folkard M, Vojnovic B., Michael BD, Suzuki K, Kodama S, Watanabe M.
  • 雑誌名: Mutat.Res. 556・1-2 ページ: 209-215
  • NAID: 130005443043
• [雑誌論文] Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. (2005)
  • 著者名/発表者名: Suzuki, M., Suzuki, K., Kodama, S., Watanabe, M.
  • 雑誌名: Biochem.Biophys.Res.Commun. 340・1 ページ: 145-150
• [雑誌論文] Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damages (2005)
  • 著者名/発表者名: Kashino, G, Kodama, S., Suzuki, K., Matsumoto, T., Watanabe, M.
  • 雑誌名: J.Radiat.Res. 46・6 ページ: 407-414
  • NAID: 110004061516
• [雑誌論文] Post-stress metabolism involves umbelliferone production in anthocyanin-producing and nonproducing cells of Glehnia littoralis suspension cultures. (2005)
  • 著者名/発表者名: Ishikawa, A., Kitamura, Y., Ozeki, Y., Itoh, Y., Yamada, A., Watanabe, M.B.
  • 雑誌名: J.Plant.Physiol. 162・6 ページ: 703-710
• [雑誌論文] Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs (2005)
  • 著者名/発表者名: Hamamoto, T., Suzuki, K., Sasaki, H., Ichikawa, M., Kodama, S., Watanabe, M.
  • 雑誌名: J.Radiat.Res. 46・2 ページ: 197-203
  • NAID: 110004041116
• [雑誌論文] Induction of Micronuclei in CHO Cells by Bleomycin but not by X-irradiation is Decreased by Treatment with HMG-CoA Reductase Inhibitors. (2005)
  • 著者名/発表者名: Iwashita, J., Kodama, S., Nakashima, M., Sasaki, H., Taniyama, K., M.Watanabe
  • 雑誌名: J.Radiat.Res. 46・2 ページ: 191-195
  • NAID: 110004041115
• [雑誌論文] Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line. (2005)
  • 著者名/発表者名: Yamauchi, M., Suzuki, K., Kodama, S., Watanabe, M.
  • 雑誌名: Biochem.Biophys.Res.Commun. 330・2 ページ: 483-488
• [雑誌論文] Radiation-induced DNA damage and delayed induced genomic instability (2004)
  • 著者名/発表者名: Suzuki K, Ojima M, Kodama S, Watanabe
  • 雑誌名: Oncogene 22 ページ: 6988-6993
• [雑誌論文] Involvement of telomere dysfunction in the induction of genomic instability by radiation in scid mouse cells (2004)
  • 著者名/発表者名: Urushibara A, Kodama S, Suzuki K, Desa M.B., Suzuki F, Tsutsui T, Watanabe M.
  • 雑誌名: Biochem Biophys Res Commun. 313 ページ: 1037-1043
• [雑誌論文] Involvement of reactive oxygen species (ROS) in the induction of genetic instability by radiation (2004)
  • 著者名/発表者名: Tominaga, H., Kodama S, Matsuda, N., Suzuki, K., Watanabe, M.
  • 雑誌名: Journal of Radiation Research 45 ページ: 181-188
  • NAID: 110002334513
• [雑誌論文] Delayed induction of telomere instability in normal human fibroblast cells by ionizing radiation (2004)
  • 著者名/発表者名: Ojima, M., Hamano, H., Suzuki, M., Suzuki, K., Kodama, S., Watanabe, M.
  • 雑誌名: Journal of Radiation Research 45 ページ: 105-110
  • NAID: 110004040999
• [雑誌論文] X-ray-induced telomeric instability in Atm-deficient mouse cells (2004)
  • 著者名/発表者名: Undarmaa, B., Kodama, S., Suzuki, K., Niwa, O., Watanabe, M.
  • 雑誌名: Biochem Biophys Res Commun. 315 ページ: 51-58
• [雑誌論文] Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. (2004)
  • 著者名/発表者名: Kashino G, Prise KM, Schettino G, Folkard M, Vojnovic B, Michael BD, Suzuki K, Kodama S, Watanabe M.
  • 雑誌名: Mutation Res. 556 ページ: 209-215
  • NAID: 130005443043
• [学会発表] The main route of radiation-induced carcinogenesis is the same as that of natural carcinogenesis. (2009)
  • 著者名/発表者名: Watanabe M, Yoshii H, Watanabe K
  • 学会等名: The 54th Annual Meeting of the Radiation Research
  • 発表場所: Boston, USA
• [学会発表] Is there a non-targeted route in radiation carcinogenesis? Is There a Non-targeted Route in Radiation Carcinogenesis Process? -Candidate Playing an Important Role (2008)
  • 著者名/発表者名: Watanabe M
  • 学会等名: In an International Symposium of Kyoto University RRI
  • 発表場所: Kumatori, Japan(Invited)
  • 年月日: 2008-12-18
• [学会発表] How to set Ikaros up as the villain in radiation lymphoma-genesis (2008)
  • 著者名/発表者名: Simada Y
  • 学会等名: In an International Symposium of Kyoto University RRI
  • 発表場所: Kumatori, Japan(Invited)
  • 年月日: 2008-12-18
• [学会発表] Amplification of intranuclear DNA damaging signal reduces genome reorganization involved in radiation-induced carcinogenesis (2008)
  • 著者名/発表者名: Suzuki K
  • 学会等名: in an International Symposium of Kyoto University RRI
  • 発表場所: Kumatori, Japan(Invited)
  • 年月日: 2008-12-18
• [学会発表] A Role of Chromosomal Instability in Carcinogenesis and Cellular Senescence (2008)
  • 著者名/発表者名: Kodama S
  • 学会等名: in an International Symposium of Kyoto University RRI
  • 発表場所: Kumatori, Japan(Invited)
  • 年月日: 2008-12-18
• [学会発表] Main route of radiation-carcinogenesis is DNA damage-independent pathways (2008)
  • 著者名/発表者名: Watanabe M, Yoshii H, Watanabe K, Suzuki K, Kodama S, Kumagai J
  • 学会等名: International congress of Radiation Research
  • 発表場所: San Fransisco
  • 年月日: 2008-08-24
• [学会発表] Mitchondria and cell transformation, In an International Symposim on "The participation of the energy metabolic system in radiation carcinogenesis process" (2008)
  • 著者名/発表者名: Yoshi H, Watanabe M
  • 学会等名: The 51th Annual Meeting of Japanese Radiation Research Society
  • 発表場所: Kokura(Invited)
• [学会発表] Mutagenic slow releasing long-lived radicals are produced from dysfunctional mitochondria (2008)
  • 著者名/発表者名: Kumagai J, Miura K, Kashino, Watanabe M
  • 学会等名: In an International Symposim on "The participation of the energy metabolic systemin radiation carcinogenesis process",The 51thAnnual Meeting of Japanese RadiationResearch Society
  • 発表場所: (Invited)
• [学会発表] The mainroute of radiation-induced carcinogenesis isthe same as that of natural carcinogenesis (2008)
  • 著者名/発表者名: Watanabe M, Yoshii H, Watanabe K
  • 学会等名: The 54th Annual Meeting of the Radiation Research Society
  • 発表場所: Boston, USA(Invited)
• [学会発表] Target of radiation carcinogenesis is protein (2008)
  • 著者名/発表者名: Watanabe M
  • 学会等名: The First InternationalSymposium on the Establishment of a NewDiscipline" Medical Care for Hibakusha"
  • 発表場所: Nagasaki(Invited)
• [学会発表] 特別講演 ; 放射線発がんの新しい機構-DNA損傷を起源としない経路の (2008)
  • 著者名/発表者名: 渡邊正己
  • 学会等名: 第14回放射線癌治療増感研究会(招待講演)
  • 発表場所: 鈴鹿
• [学会発表] 細胞がん化には倍数化より異数化が深く関与する (2008)
  • 著者名/発表者名: 渡漫正己, 吉居華子
  • 学会等名: 第67回日本癌学会学術総会
  • 発表場所: 名古屋
• [学会発表] ミトコンドリア機能と細胞がん化 (2008)
  • 著者名/発表者名: 渡洛正己, 吉居華子
  • 学会等名: 第8回日本ミトコンドリア学会
  • 発表場所: 東京
• [学会発表] Plenary Lecture I, The mainroute of radiation carcinogenesis-The firsttarget of radiation-induced carcinogenesis isnot DNA (2007)
  • 著者名/発表者名: Watanabe M
  • 学会等名: International Symposium of Korea University Brain Korea 21 Program for Biomedical Sciences
  • 発表場所: Seoul(Invited)
  • 年月日: 2007-01-23
• [学会発表] Main route of radiation-carcinogenesis is DNA damage- independentpathway. (2007)
  • 著者名/発表者名: Watanabe M, Yoshii H, Watanabe K, Suzuki K, Kodama S, Kumagai J
  • 学会等名: 13th International Congress of Radiation Research
  • 発表場所: San Francisco(Invited)
• [図書] 突然変異は放射線発がんの主因ではない、モデルが拓く放射線防護研究の新たな展開-第一回放射線防護研究センターシンポジウム(根井充編)(64-70) (2007)
  • 著者名/発表者名: 渡辺正己
  • 出版者: 放射線医学総合研究所
• [図書] 放射線発がんの主たる標的はDNAではない可能性が高い(25(5)) (2007)
  • 著者名/発表者名: 渡辺正己
  • 出版者: ESI-NEWS
• [備考]
  • URL: http://www.rri.kyoto-u.ac.jp/rb-rri/
• [備考]
  • URL: http://www.rri.kyoto-u.ac.jp/rb-rri/
• [備考]
  • URL: http://www.rri.kyoto-u.ac.jp/rb-rri/