| 研究課題/領域番号 |
16F16720
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 補助金 |
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| 応募区分 | 外国 |
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| 研究分野 |
生体医工学・生体材料学
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
SHEN Amy 沖縄科学技術大学院大学, マイクロ・バイオ・ナノ流体ユニット, 教授 (70740314)
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| 研究分担者 |
LEUNG HEI MAN 沖縄科学技術大学院大学, マイクロ・バイオ・ナノ流体ユニット, 外国人特別研究員
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| 研究期間 (年度) |
2016-07-27 – 2017-03-31
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| 研究課題ステータス |
完了 (2016年度)
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| 配分額 *注記 |
1,200千円 (直接経費: 1,200千円)
2016年度: 1,200千円 (直接経費: 1,200千円)
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| キーワード | Microfluidics / Nanoprecipitation / Nanoparticles / Dynamic light scattering / Curcumin / Drug delivery |
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| 研究実績の概要 |
The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.
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| 現在までの達成度 (段落) |
28年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
28年度が最終年度であるため、記入しない。
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