オートファジー性神経細胞死の分子細胞生物学的研究

• 研究課題/領域番号: 16GS0315
• 研究種目: 学術創成研究費
• 配分区分: 補助金
• 研究機関: 順天堂大学 (2008); 大阪大学 (2004-2007)
• 研究代表者: 内山 安男 順天堂大学, 医学部, 教授 (10049091)
• 研究分担者: 和栗 聡 福島県立医科大学, 医学部, 教授 (30244908) ; 柴田 昌宏 新潟大学, 医歯学系, 准教授 (10343253) ; 小池 正人 順天堂大学, 医学部, 准教授 (80347210) ; 佐々木 光穂 順天堂大学, 医学部, 助教 (20432536) ; 上野 隆 順天堂大学, 医学部, 准教授 (10053373) ; 後藤 邦仁 大阪大学, 医学系研究科, 助手 (10362716) ; 谷田 以誠 順天堂大学, 医学部, 講師 (30296868)
• 研究期間 (年度): 2004 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 481,390千円 (直接経費: 370,300千円、間接経費: 111,090千円); 2008年度: 72,280千円 (直接経費: 55,600千円、間接経費: 16,680千円); 2007年度: 81,120千円 (直接経費: 62,400千円、間接経費: 18,720千円); 2006年度: 106,860千円 (直接経費: 82,200千円、間接経費: 24,660千円); 2005年度: 109,590千円 (直接経費: 84,300千円、間接経費: 25,290千円); 2004年度: 111,540千円 (直接経費: 85,800千円、間接経費: 25,740千円)
• キーワード: オートファジー / 神経細胞 / リソソーム / カテプシン / 脳虚血 / オートファジー性神経細胞死 / 低酸素-脳虚血 / Atg7 / LC3 / ミュータントマウス / リソソームプロテアーゼ / 脂肪代謝 / 低酸素脳虚血傷害 / LC3欠損マウス / Atg7欠損マウス / カテプシンB / カテプシンL / カテプシンD / 細胞死 / ノックアウトマウス / 神経細胞死 / オートファゴソーム / プロテアーゼ / Atg7-KOマウス / ユビキチン / 低酸素能虚血負荷 / 海馬CA1錘体細胞死 / RNAi / DNAマイクロアレイ

研究概要

新生仔マウスを用いた低酸素-脳虚血負荷モデルは、ヒト新生児の低酸素-虚血性脳症に類似する。しかし、これまでその傷害の実態は不明であった。私達は、オートファジーをできないマウスを用いて低酸素負荷実験を行ない、海馬錐体細胞の死が防御されることを示した。即ち、本研究で低酸素-脳虚血負荷による錐体細胞の死がオートファジー性によることを遺伝学的に初めて実証することができた。この結果は、治療手段を考える上で極めて重要である。

研究成果

• [雑誌論文] LC3, a microtubule-associated proteinlA/B light chain3, is involved in cytoplasmic lipid droplet formation. (2010)
  • 著者名/発表者名: Shibata Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T, Sasaki M, Koike M, Arai H, Kominami E, Uchiyama Y
  • 雑誌名: BBRC 393 ページ: 274-279
• [雑誌論文] Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains. (2010)
  • 著者名/発表者名: Tamura H, Shibata M, Koike M, Sasaki M, Uchiyama Y
  • 雑誌名: J Histochem Cytochem 58 ページ: 443-453
• [雑誌論文] Chondrogenesis during the ES cell differentiation in vitro. (2010)
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  • 雑誌名: PNAS 107 ページ: 3846-3851
• [雑誌論文] LC3, a microtubule-associated proteinlA/B light chain3, is involved in cytoplasmic lipid droplet formation (2010)
  • 著者名/発表者名: Shibata M, Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T, Sasaki M, Koike M, Arai H, Kominami E, Uchiyama Y
  • 雑誌名: Biophys Biochem Res Comm 393 ページ: 274-279
  • 査読あり
• [雑誌論文] Chondrogenesis during the ES cell differentiation in vitro (2010)
  • 著者名/発表者名: Yagita Y, Horie K, Yamanaka I, Koinuma S, Shigeyoshi Y, Kawakami K, Takeda J, Uchiyama Y
  • 雑誌名: PNAS 107 ページ: 3846-3851
  • 査読あり
• [雑誌論文] Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains (2010)
  • 著者名/発表者名: Tamura H, Shibata M, Koike M, Sasaki M, Uchiyama Y
  • 雑誌名: J Histochem Cytochem
  • 査読あり
• [雑誌論文] The MAP1-LC3 conjugation system is involved in lipid droplet formation. (2009)
  • 著者名/発表者名: Shibata M*, Yoshimura K*, Furuya M, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y
  • 雑誌名: BBRC 382 ページ: 419-423
• [雑誌論文] The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. (2009)
  • 著者名/発表者名: Nada S*, Hondo A*, Kasai A*, Koike M*, Saito K, Uchiyama Y, Okada M
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  • 著者名/発表者名: Gotoh K, Lu Z, Morita M, Shibata M, Koike M, Waguri S, Dono K, Doki Y, Kominami E, Sugioka A, Monden M, Uchiyama Y
  • 雑誌名: Autophagy 5 ページ: 351-360
• [雑誌論文] The MAP1-LC3 conjugation system is involved in lipid droplet formation (2009)
  • 著者名/発表者名: Shibata M^*, Yoshimura K^*, Furuya M, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y(^* equally contributed)
  • 雑誌名: Biophys Biochem Res Comm 382 ページ: 419-423
  • 査読あり
• [雑誌論文] The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes (2009)
  • 著者名/発表者名: Nada S^*, Hondo A^*, Kasai A^*, Koike M^*, Saito K, Uchiyama Y, Okada M(^*equally contri buted)
  • 雑誌名: EMBO J 28 ページ: 477-489
  • 査読あり
• [雑誌論文] Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation (2009)
  • 著者名/発表者名: Gotoh K, Lu Z, Morita M, Shibata M, Koike M, Waguri S, DonoK, DokiY, Kominami E, Sugioka A, Monden M, Uchiyama Y
  • 雑誌名: Autophagy 5 ページ: 351-360
  • 査読あり
• [雑誌論文] Phosphorylation of highly conserved NF-M KSP repeats is not required for myelin-dependent radial axonal growth (2009)
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  • 雑誌名: J Nurosci 29 ページ: 1277-1284
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• [雑誌論文] Nesfatin-1-regulated paraventricular oxytocinergic signaling causes anorexia through a leptin-independent melanocortin pathway (2009)
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  • 雑誌名: Cell Metabolism 10 ページ: 355-365
  • 査読あり
• [雑誌論文] Ablation of C/EBP beta alleviates ER stress and pancreatic beta cell failure through induction of GRP78 (2009)
  • 著者名/発表者名: Matsuda, T., Kido, Y., Nakano-Hashimoto, N., Kaisho, T., Tanaka, T., Asahara, S., Shigeyama, Y., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., Hosooka, T., Matsumoto, M., Inoue, H., Uchida, T., Koike, M., Uchiyama, Y., Akira, S., Kasuga, M.
  • 雑誌名: J Clin Invest 120 ページ: 115-126
  • 査読あり
• [雑誌論文] Mini Screening of Kinase Inhibitors Affecting Period-length of Mammalian Cellular Circadian Clock (2009)
  • 著者名/発表者名: Yagita K, Yamanaka I, Koinuma S, Shigeyoshi Y, Uchiyama Y
  • 雑誌名: Acta Histochem Cytochem 42 ページ: 89-93
  • NAID: 130000118206
  • 査読あり
• [雑誌論文] Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions (2009)
  • 著者名/発表者名: Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M.
  • 雑誌名: J Immunol 183 ページ: 5013-5022
  • 査読あり
• [雑誌論文] Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb (2009)
  • 著者名/発表者名: Ohsawa S, Hamada S, Asou H, Kuida K, Uchiyama Y, Yoshida H, Miura M.
  • 雑誌名: J Neurosci 29 ページ: 11385-11292
  • 査読あり
• [雑誌論文] Very-high-dose alpha-tocopherol supplementation increases blood pressure and causes possible adverse central nervous system effects in stroke-prone spontaneously hypertensive rats (2009)
  • 著者名/発表者名: Miyamoto K, Shiozaki M, Shibaita M, Koike M, Uchiyama Y, Gotow T
  • 雑誌名: J Neurosci Res 87 ページ: 556-566
  • 査読あり
• [雑誌論文] (2009)
  • 著者名/発表者名: Uchiyama Y, et al.
  • 雑誌名: Chapter 3 Autophagic neuron death. In : Autophagy in Disease and Clinical Applications, Part C (Edited by : Daniel J.Rlionsky Vol.453)(Elsevier Inc.) ページ: 33-51
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  • 著者名/発表者名: Uchiyama Y, et al.
  • 雑誌名: Autophagy and cell death. In : Molecular imaging for integrated medical therapy and drug development.( Ed.YujiKuge)(Springer Japan) ページ: 176-188
• [雑誌論文] Autophagy-Physiology and Pathophysiology. (2008)
  • 著者名/発表者名: Uchiyama Shibata M, Koike M, Yoshimura K, Sasaki M
  • 雑誌名: Histochem Cell Biol 129 ページ: 407-420
• [雑誌論文] Autophagic neuron death in neonatal brain ischemia/hypoxia. (2008)
  • 著者名/発表者名: Uchiyama Y, Koike M, Shibata M
  • 雑誌名: Autophagy 4 ページ: 404-408
• [雑誌論文] Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. (2008)
  • 著者名/発表者名: Koike M, Shibata S, Tadakoshi T, Gotoh K, Komatsu M, Waguri S, KawaharaN, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y
  • 雑誌名: Am J Pathol 172 ページ: 454-469
• [雑誌論文] Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. (2008)
  • 著者名/発表者名: Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie Z-L, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, LuYM, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J
  • 雑誌名: Mol Brain 1 ページ: 17-17
• [雑誌論文] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. (2008)
  • 著者名/発表者名: Sou YS, Waguri S, Iwata JI, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M
  • 雑誌名: Mol Biol Cell 19 ページ: 4762-4775
• [雑誌論文] GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (2008)
  • 著者名/発表者名: Maeda Y, Ide T, Koike M, Uchiyama Y, Kinoshita T
  • 雑誌名: Nat Cell Biol 10 ページ: 1135-1145
• [雑誌論文] Human herpesvirus-6 induces MVB formation and virus egress occurs via an exosomal release pathway. (2008)
  • 著者名/発表者名: Mori Y*, Koike M*, Moriishi E, Kawabata A, Tang H, Oyaizu H, Uchiyama Y, Yamanishi K
  • 雑誌名: Traffic 9 ページ: 1728-1742
• [雑誌論文] Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy. (2008)
  • 著者名/発表者名: Oppenheim RW, Blomgren K, Ethell DW, Koike M, Komatsu M, Prevette D, Roth KA, Uchiyama Y, Vinsant S, Zhu C
  • 雑誌名: J Neurosci 28 ページ: 1490-1497
• [雑誌論文] Participation of autophagy in renal ischemia/reperfusion injury. (2008)
  • 著者名/発表者名: Suzuki C, Takabatake Y, Tanaka H, Koike M, Shibata M, Uchiyama Y, Takahara S, Imai E, Isaka Y
  • 雑誌名: BBRC 368 ページ: 100-106
• [雑誌論文] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. (2008)
  • 著者名/発表者名: Klionsky DJ, et al(alphabeticalに220番目)
  • 雑誌名: Autophagy 4 ページ: 151-175
• [雑誌論文] Autophagy-Physiology and Pathophysiology (2008)
  • 著者名/発表者名: Uchiyama, Y., Shibata, M., Koike, M., Yoshimura, K., Sasaki, M.
  • 雑誌名: Histochem Cell Biol 129 ページ: 407-420
  • 査読あり
• [雑誌論文] Autophagic neuron death in neonatal brain ischemia/hypoxia (2008)
  • 著者名/発表者名: Uchiyama, Y., Koike, M., Shibata, M.
  • 雑誌名: Autophagy 4 ページ: 404-408
  • 査読あり
• [雑誌論文] Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses (2008)
  • 著者名/発表者名: Fujimoto M, Serada S, Mihara M, Uchiyama Y, Yoshida H, Koike N, Ohsugi Y, Nishikawa T, Ripley B, Kimura A, Kishimoto T, Naka T.
  • 雑誌名: Arthritis Rheum 58 ページ: 3710-3719
  • 査読あり
• [雑誌論文] Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity (2008)
  • 著者名/発表者名: Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie Z-L, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J
  • 雑誌名: Mol Brain 1 ページ: 17-17
  • 査読あり
• [雑誌論文] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice (2008)
  • 著者名/発表者名: Sou YS, Waguri S, Iwata JI, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M
  • 雑誌名: Mol Biol Cell 19 ページ: 4762-4775
  • 査読あり
• [雑誌論文] GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus (2008)
  • 著者名/発表者名: Maeda Y, Ide T, Koike M, Uchiyama Y, Kinoshita T
  • 雑誌名: Nat Cell Biol 10 ページ: 1135-1145
  • 査読あり
• [雑誌論文] Human herpesvirus-6 induces MVB formation and virus egress occurs via an exosomal release pathway (2008)
  • 著者名/発表者名: Mori Y^*, Koike M^*, Moriishi E, Kawabata A, Tang H, Oyaizu H, Uchiyama Y, Yamanishi K^*equal contributors
  • 雑誌名: Traffic 9 ページ: 1728-1742
  • 査読あり
• [雑誌論文] Inefficient phagosome maturation in infant macrophages (2008)
  • 著者名/発表者名: Saito F, Kuwata H, Oiki E, Koike M, Uchiyama Y, Honda K, Takeda K
  • 雑誌名: Biochem Biophys Res Commun 375 ページ: 113-118
  • 査読あり
• [雑誌論文] LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers (2008)
  • 著者名/発表者名: Yoshida A, Miyata H, Doki Y, Yamasaki M, Sohma I, Gotoh K, Takiguchi S, Fujiwara Y, Uchiyama Y, Monden M
  • 雑誌名: Int J Oncol 33 ページ: 461-468
  • 査読あり
• [雑誌論文] Developing postmitotic mammalian neurons in vivo lacking. Apaf-1 and ergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy (2008)
  • 著者名/発表者名: Oppenheim RW, Blomgren K, Ethell DW, Koike M, Komatsu M, Prevette D, Roth KA, Uchiyama Y, Vinsant S, Zhu C
  • 雑誌名: J Neurosci 28 ページ: 1490-1497
  • 査読あり
• [雑誌論文] Morphological and biochemical signs of age-related neurodegenerative changes in Klotho mutant mice (2008)
  • 著者名/発表者名: Shiozaki M, Yoshimura K, Shibata M, Koike M, Uchiyama Y, Gotow T
  • 雑誌名: Neurcience 152 ページ: 924-941
  • 査読あり
• [雑誌論文] Detection of a circadian enhancer in the mDbp promoter using prokaryotic transposon vector based strategy (2008)
  • 著者名/発表者名: Kiyohara Y, Nishii K, Ukai-Tadenuma M, Ueda H, Uchiyama Y, Yagita K
  • 雑誌名: Nucl Acids Res 36(4)
  • 査読あり
• [雑誌論文] Participation of autophagy in renal ischemia/reperfusion injury (2008)
  • 著者名/発表者名: Suzuki C, Takabatake Y, Tanaka H, Koike M, Shibata M, Uchiyama Y, Takahara S, Imai E, Isaka Y
  • 雑誌名: Biochem Biophys Res Comm 368 ページ: 100-106
  • 査読あり
• [雑誌論文] Human RME-8 is involved in membrane trafficking through early endosomes (2008)
  • 著者名/発表者名: Fujibayashi A, Taguchi T, Misaki R, Ohtani M, Dohmae N, Takio K, Yamada M, Gu J, Yamakami M, Fukuda M, Waguri S, Uchiyama Y, Yoshimori T, Sekiguchi K
  • 雑誌名: Cell Struct Funct 33 ページ: 35-50
  • NAID: 130004053865
  • 査読あり
• [雑誌論文] Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility (2008)
  • 著者名/発表者名: Takatsuka A, Yagi R, Koike M, Oneyama C, Nada S, Schmedt C, Uchiyama Y, Okada M
  • 雑誌名: Dev Biol 315 ページ: 474-488
  • 査読あり
• [雑誌論文] The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse (2008)
  • 著者名/発表者名: Hasegawa S, Hamada S, Kumode Y, Esumi S, Katori S, Fukuda E, Uchiyama Y, Hirabayashi T, Mombaerts P, Yagi T
  • 雑誌名: Mol Cell Neurosci 38 ページ: 66-79
  • 査読あり
• [雑誌論文] Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury (2008)
  • 著者名/発表者名: Koike M, Shibata S, Tadakoshi T, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y
  • 雑誌名: Am J Pathol 172 ページ: 454-469
  • 査読あり
• [雑誌論文] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008)
  • 著者名/発表者名: Klionsky DJ, et al.
  • 雑誌名: Autophagy 4 ページ: 151-175
  • 査読あり
• [雑誌論文] Autophagy Physiology and Pathophysiology. (2008)
  • 著者名/発表者名: Uchiyama, Y.
  • 雑誌名: Histochem Cell Biol (in press)
  • 査読あり
• [雑誌論文] Autophagic neuron death in neonatal brain ischemia/hypoxia. (2008)
  • 著者名/発表者名: Uchiyama, Y.
  • 雑誌名: Autophagy (in press)
  • 査読あり
• [雑誌論文] Morphological and biochemical signs of age-related neurodegenerative changes in Klotho mutant mice. (2008)
  • 著者名/発表者名: Shiozaki M
  • 雑誌名: Neuroscience (in press)
  • 査読あり
• [雑誌論文] Detection of a circadian enhancer in the mDbp promoter using prokaryotic transposon vector based strategy. (2008)
  • 著者名/発表者名: Kiyohara Y
  • 雑誌名: Nucl Acids Res (in press)
  • 査読あり
• [雑誌論文] Participation of autophagy in renal ischemia/reperfusion injury. (2008)
  • 著者名/発表者名: Suzuki C
  • 雑誌名: Biochem Biophys Res Comm (in press)
  • 査読あり
• [雑誌論文] Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine. (2008)
  • 著者名/発表者名: Somboonthum F
  • 雑誌名: Vaccine (in press)
  • 査読あり
• [雑誌論文] Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. (2008)
  • 著者名/発表者名: Koike M
  • 雑誌名: Am J Pathol 172 ページ: 454-69
  • 査読あり
• [雑誌論文] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. (2008)
  • 著者名/発表者名: Klionsky DJ
  • 雑誌名: Autophagy 4 ページ: 151-175
  • 査読あり
• [雑誌論文] Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells. (2007)
  • 著者名/発表者名: Hida T, Ikeda H, Kametaka S, Akazawa S, Kohsaka S, Ebisu S, Uchiyama Y, Waguri S
  • 雑誌名: Arch Histol Cytol 70 ページ: 303-312
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• [学会発表] Cell Death and Autophagy (2009)
  • 著者名/発表者名: 内山安男
  • 学会等名: International Symposium on Autophagy and Cell Death
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  • 年月日: 2009-07-04
• [学会発表] Autophagy and other pathomechanisms (2009)
  • 著者名/発表者名: 内山安男
  • 学会等名: 12^<th> International Congress on Neuronal Ceroid Lipofuscinoses(NCL)
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• [学会発表] Involvement of autophagy in pathogenesis of neuronal ceroid lipofuscinosis (2009)
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  • 学会等名: 12th International Congress on Neuronal Ceroid Lipofuscinoses (NCL) in Hamburg
  • 発表場所: Germany
• [学会発表] Autophagy and cell death (2009)
  • 著者名/発表者名: 内山安男
  • 学会等名: 5^<th> International Symposium on Autophagy
  • 発表場所: 大津プリンスホテルコンベンションホール
• [学会発表] Morphological aspects of autophagy : Identification and possible mechanism of autophagosome formation in neuronal cells (2009)
  • 著者名/発表者名: 内山安男
  • 学会等名: Microscopy Conference 2009
  • 発表場所: オーストリア グラーツ
• [学会発表] オートラァジー/リソソーム制裁防正万秀子細胞生物学的研究 (2008)
  • 著者名/発表者名: 内山安男
  • 学会等名: 平成2 0年度顕微鏡学会瀬藤賞受賞講演
  • 発表場所: 千葉大学
  • 年月日: 2008-10-17
• [学会発表] オートファジー/リソソーム制裁防止の分子細胞生物学的研究 (2008)
  • 著者名/発表者名: 内山安男
  • 学会等名: 平成20年度顕微鏡学会瀬藤賞受賞講演
  • 発表場所: 千葉大学
  • 年月日: 2008-10-17
• [学会発表] Impairment and acceleration of autophagy result in neurodegeneration. (2008)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: The 5th Asia Pacific International Congress of Anatomists
  • 発表場所: Tehran
• [学会発表] p62/A170/SQSTM1, a binding partner of ubiquitin and LC3, and lysosomal storage disorder (2008)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: Neuroscience 2008 in the 31st Annual Meeting
  • 発表場所: Tokyo
• [学会発表] Impairment and acceleration of autophagy: neurodegeneration (2008)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: In the 20th International Symposium on Morphological Science in Timisoara
  • 発表場所: Plenary Lecture
• [学会発表] p62/A170/SQSTM1, a binding partner of ubiquitin and LC3, and lysosomal storage Disorder (2008)
  • 著者名/発表者名: 内山安男
  • 学会等名: 第31回日本神経科学会シンポジウム(SY3AE1)
  • 発表場所: 東京国際フォーラム
• [学会発表] p62/A170/SQSTM1, a binding partner of ubiquitin and LC3, and lysosomal storage Disorder (2008)
  • 著者名/発表者名: 内山安男
  • 学会等名: 第5回アジア太平洋解剖学会(APICA)
  • 発表場所: イラン テヘラン
• [学会発表] In: Neuronal macroautophagy, autophagic stress, and neurological diseses (2007)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: Neuroscience
  • 発表場所: in San Diego
• [学会発表] Involvement of autophagy in neuron death of neonatal mouse brains after hypoxic-ischemic injury (2006)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: In: The 4th Internation Symposium of Autophagy
  • 発表場所: in Mishima
• [学会発表] Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten Disease) (2005)
  • 著者名/発表者名: Uchiyama Y, Shibata M, Koike M
  • 学会等名: International conference on serine-carboxyl peptidases and related enzymes
  • 発表場所: in Kyoto
  • 年月日: 2005-11-10
• [学会発表] Roles of lysosomal proteinases in autophagic cell death (2005)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: 2005 Gordon Research Conference on "Autophagy in Stress, Development & Disease" in Il
  • 発表場所: Ciocco
• [学会発表] cathepsin D deficiency induces caspase dependent and independent neuron death (2004)
  • 著者名/発表者名: Uchiyama Y
  • 学会等名: Symp-55, 16th International congress of the IFAA
• [図書] Molecular imaging for integrated medical therapy and drug development(Eds. Nagara Tamaki and Yuji Kuge, Autophagy and cell death) (2010)
  • 著者名/発表者名: Uchiyama Y, Koike M, Shibata M
  • 出版者: Springer Japan
• [図書] Methods Enzymol. Vol.453 (Autophagy in Disease and Clinical Applications, Part C)(Ed. Daniel J. Klionsky, Autophagic neuron death) (2009)
  • 著者名/発表者名: Uchiyama Y, Koike M, Shibata M, Sasaki M
• [備考]
  • URL: http://www.juntendo.ac.jp/graduate/laboratorynabo/shinkei_kozo/index.html