p53遺伝子ファミリーの機能解析とがん治療への応用

• 研究課題/領域番号: 17013072
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 札幌医科大学
• 研究代表者: 時野 隆至 札幌医科大学, 医学部, 教授 (40202197)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 47,000千円 (直接経費: 47,000千円); 2009年度: 9,400千円 (直接経費: 9,400千円); 2008年度: 9,400千円 (直接経費: 9,400千円); 2007年度: 9,400千円 (直接経費: 9,400千円); 2006年度: 9,400千円 (直接経費: 9,400千円); 2005年度: 9,400千円 (直接経費: 9,400千円)
• キーワード: 癌 / 癌抑制遺伝子 / 遺伝子治療 / p53 / p63 / p73 / アポトーシス / ウイルスベクター / がん / がん抑制遺伝子 / がん治療

研究概要

ゲノムインフォマティクスを利用した新規p53標的遺伝子の予測は、発現解析との組合せによって新規標的遺伝子の同定に有用なこと明らかにした。マイクロアレイを利用したp73およびp63特異的標的遺伝子の検索を行い、新たにPEDF、FLOT2およびAPODなどの同定に成功した。p53ファミリー組換えアデノウイルスは、マウスモデルでの骨肉腫に対する遺伝子治療においてp53に比較して強力な腫瘍抑制効果を得た。また、p53とヒストン脱アセチル化酵素阻害剤FK228との併用効果もマウスモデルにおいて明らかにした。

研究成果

• [雑誌論文] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (2010)
  • 著者名/発表者名: Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
  • 雑誌名: Carcinogenesis 31(3) ページ: 342-349
  • 査読あり
• [雑誌論文] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cencer. (2010)
  • 著者名/発表者名: Fujikane, Tomoko, et al
  • 雑誌名: Breast Cancer Res Treat (in press)
  • 査読あり
• [雑誌論文] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (2010)
  • 著者名/発表者名: Suzuki, Hiromu, et al
  • 雑誌名: Carcinigenesis VOL.31 ページ: 342-349
  • 査読あり
• [雑誌論文] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • 著者名/発表者名: Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
  • 雑誌名: Clinical Cancer Research 15(11) ページ: 3725-3732
  • 査読あり
• [雑誌論文] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2009)
  • 著者名/発表者名: Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
  • 雑誌名: Oncogene 28(29) ページ: 2643-2653
  • 査読あり
• [雑誌論文] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • 著者名/発表者名: Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
  • 雑誌名: J Biol Chem 284(2) ページ: 872-883
  • 査読あり
• [雑誌論文] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. (2009)
  • 著者名/発表者名: Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
  • 雑誌名: BMC Cancer 9 ページ: 198-198
  • 査読あり
• [雑誌論文] A novel biomarker for cervical cancer. (2009)
  • 著者名/発表者名: Tokino T
  • 雑誌名: Cancer Biology Therapy 8(12) ページ: 1154-1155
  • 査読あり
• [雑誌論文] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma. (2009)
  • 著者名/発表者名: Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
  • 雑誌名: Clinical Cancer Research 15(13) ページ: 4356-4364
  • 査読あり
• [雑誌論文] Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy. (2009)
  • 著者名/発表者名: Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
  • 雑誌名: Cancer Science 100(5) ページ: 787-791
  • NAID: 10025145027
  • 査読あり
• [雑誌論文] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity. (2009)
  • 著者名/発表者名: Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
  • 雑誌名: Int J Cancer 124(11) ページ: 2607-2615
  • 査読あり
• [雑誌論文] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • 著者名/発表者名: Sasaki, Yasushi, et al
  • 雑誌名: J Biological Chemistry VOL.284 ページ: 872-883
  • 査読あり
• [雑誌論文] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • 著者名/発表者名: Idogawa, Masashi, et al
  • 雑誌名: Clinical Cancer Res VOL.15 ページ: 3725-3732
  • 査読あり
• [雑誌論文] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2009)
  • 著者名/発表者名: Kashima, Lisa, et al
  • 雑誌名: Oncogene VOL.28 ページ: 2643-2653
  • 査読あり
• [雑誌論文] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers : involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. (2009)
  • 著者名/発表者名: Mita, Hiroaki, et al
  • 雑誌名: BMC Cancer VOL.9(Online) ページ: 198-198
  • 査読あり
• [雑誌論文] A novel biomarker for cervical cancer. (2009)
  • 著者名/発表者名: Tokino, Takashi
  • 雑誌名: Cancer Biology Therapy VOL.8 ページ: 1154-1155
  • 査読あり
• [雑誌論文] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multipel myeloma. (2009)
  • 著者名/発表者名: Nojima, Masanori, et al
  • 雑誌名: Clinical Cancer Res VOL.15 ページ: 4356-4364
  • 査読あり
• [雑誌論文] Cancer epigenomics : Implications of DNA methylation in personalized cancer therapy. (2009)
  • 著者名/発表者名: Toyots, Minoru, et al
  • 雑誌名: Cancer Science VOL.100 ページ: 787-791
  • 査読あり
• [雑誌論文] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected Tcells through enhanced NF-kappaB activity. (2009)
  • 著者名/発表者名: Tomita, Markiko, et al
  • 雑誌名: Int J Cancer VOL.124 ページ: 2607-2615
  • 査読あり
• [雑誌論文] p53 family members regulate the expression of the apolipoprotein D gene (2009)
  • 著者名/発表者名: Sasaki Y, et.al.
  • 雑誌名: J Biol Chem 284 ページ: 872-883
  • 査読あり
• [雑誌論文] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells (2009)
  • 著者名/発表者名: Idogawa M, et.al.
  • 雑誌名: Clinical Cancer Research (印刷中)
  • 査読あり
• [雑誌論文] Cancer epigenomics : Implications of DNA methylation in personalized cancer therapy (2009)
  • 著者名/発表者名: Toyota M, et.al.
  • 雑誌名: Cancer Science (印刷中)
  • 査読あり
• [雑誌論文] The histone deacetylase inhibitor FK228 enhances adenovirusmediated p53 family gene therapy in cancer models. (2008)
  • 著者名/発表者名: Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
  • 雑誌名: M o l e c u l a r C a n c e r T h e r a p e u t i c s 7(4) ページ: 779-787
  • 査読あり
• [雑誌論文] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. (2008)
  • 著者名/発表者名: Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
  • 雑誌名: M o l e c u l a r C a n c e r R e s 6(3) ページ: 395-406
  • 査読あり
• [雑誌論文] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer. (2008)
  • 著者名/発表者名: Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
  • 雑誌名: G a s t r o e n t e r o l o g y 135(1) ページ: 142-151
  • 査読あり
• [雑誌論文] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. (2008)
  • 著者名/発表者名: Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
  • 雑誌名: C a n c e r R e s e a r h 68(8) ページ: 2570-2575
  • 査読あり
• [雑誌論文] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer. (2008)
  • 著者名/発表者名: Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
  • 雑誌名: C a n c e r R e s e a r c h 68(11) ページ: 4124-4132
  • 査読あり
• [雑誌論文] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer. (2008)
  • 著者名/発表者名: Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
  • 雑誌名: C a r c i n o g e n e s i s 29(7): 29(7) ページ: 1312-1318
  • 査読あり
• [雑誌論文] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. (2008)
  • 著者名/発表者名: Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
  • 雑誌名: B r J C a n c e r 98(6) ページ: 1147-1156
  • 査読あり
• [雑誌論文] DNA methylation and cancer pathways in gastrointestinal tumors. (2008)
  • 著者名/発表者名: Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
  • 雑誌名: P h a r m a c o g e n o m i c s 9(12) ページ: 1917-1928
  • 査読あり
• [雑誌論文] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma. (2008)
  • 著者名/発表者名: Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
  • 雑誌名: C a n c e r S c i e n c e 99(5) ページ: 958-966
  • NAID: 10024006089
  • 査読あり
• [雑誌論文] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. (2008)
  • 著者名/発表者名: Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
  • 雑誌名: I n t J O n c o l o g y 32(6) ページ: 1253-1261
  • 査読あり
• [雑誌論文] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis. (2008)
  • 著者名/発表者名: Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
  • 雑誌名: C a n c e r E p i d e m i o l B i o m a r k e r s P r e v 17(10) ページ: 2555-2564
  • 査読あり
• [雑誌論文] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. (2008)
  • 著者名/発表者名: Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
  • 雑誌名: J G a s t r o e n t e r o l 43(5) ページ: 378-389
  • NAID: 10021268741
  • 査読あり
• [雑誌論文] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells. (2008)
  • 著者名/発表者名: Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
  • 雑誌名: J H e p a t o b i l i a r y P a n c r e a t S u r g 15(3) ページ: 310-317
  • NAID: 10024157037
  • 査読あり
• [雑誌論文] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models (2008)
  • 著者名/発表者名: Sasaki Y, et.al.
  • 雑誌名: Molecular Cancer Therapeutics 7 ページ: 779-787
  • 査読あり
• [雑誌論文] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members (2008)
  • 著者名/発表者名: Sasaki Y, et.al.
  • 雑誌名: Molecular Cancer Research 6 ページ: 395-406
  • 査読あり
• [雑誌論文] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methvlation in colorectal cancer (2008)
  • 著者名/発表者名: Toyota M, et.al.
  • 雑誌名: Cancer Resaech 68 ページ: 4124-4132
  • 査読あり
• [雑誌論文] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells (2008)
  • 著者名/発表者名: Ting AH, et.al.
  • 雑誌名: Cancer Research 68 ページ: 2570-2575
  • 査読あり
• [雑誌論文] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is enieenetically silenced in gastric cancer (2008)
  • 著者名/発表者名: Maruyama R, et.al.
  • 雑誌名: Carcinogenesis 29 ページ: 1312-1318
  • 査読あり
• [雑誌論文] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer (2008)
  • 著者名/発表者名: Suzuki H, et.al.
  • 雑誌名: British J Cancer 98 ページ: 1147-1156
  • 査読あり
• [雑誌論文] DNA methlation and cancer pathways in gastrointestinal tumors (2008)
  • 著者名/発表者名: Suzuki H, et.al.
  • 雑誌名: Pharmacogenomics 9 ページ: 1917-1928
  • 査読あり
• [雑誌論文] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma (2008)
  • 著者名/発表者名: Imai T, et.al.
  • 雑誌名: Cancer Science 99 ページ: 958-966
  • 査読あり
• [雑誌論文] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma (2008)
  • 著者名/発表者名: Sogabe Y, et.al.
  • 雑誌名: Int J Oncology 32 ページ: 1253-1261
  • 査読あり
• [雑誌論文] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer (2008)
  • 著者名/発表者名: Kawamura YI, et.al.
  • 雑誌名: Gastroenterology 135 ページ: 142-151
  • 査読あり
• [雑誌論文] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma (2008)
  • 著者名/発表者名: Takagi H, et.al.
  • 雑誌名: J Gastroenterol 43 ページ: 378-389
  • 査読あり
• [雑誌論文] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis (2008)
  • 著者名/発表者名: Yamamoto E, et.al.
  • 雑誌名: Cancer Epidemiol Biomakers Prey 17 ページ: 2555-2564
  • 査読あり
• [雑誌論文] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells (2008)
  • 著者名/発表者名: Kawasaki H, et.al.
  • 雑誌名: J Hepatobiliary Pancreat Surg 15 ページ: 310-317
  • 査読あり
• [雑誌論文] Prediction of p53 target genes based on integrative analysis of chromatin-immunoprecipitated and sequenced tags, by using Galaxy, aweb-based interactive platform for large-scale genome analysis (2008)
  • 著者名/発表者名: Mita H, et.al.
  • 雑誌名: Tumor Research 43 ページ: 1-23
• [雑誌論文] Gene Amplification and Overexpression of PRDM14 in Breast Cancers. (2007)
  • 著者名/発表者名: Nishikawa N, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
  • 雑誌名: C a n c e r R e s e a r c h 67(20) ページ: 9649-9657
  • 査読あり
• [雑誌論文] Antitumor effect of adenovirusmediated p53 family gene transfer on osteosarcoma cell lines. (2007)
  • 著者名/発表者名: Oshima Y, Sasaki Y, Negishi H, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
  • 雑誌名: C a n c e r B i o l o g y T h e r a p y 6(7) ページ: 1058-1066
  • 査読あり
• [雑誌論文] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer. (2007)
  • 著者名/発表者名: Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Tokino T
  • 雑誌名: C l i n i c a l C a n c e r R e s 13(16) ページ: 4786-4794
  • 査読あり
• [雑誌論文] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate betacatenine and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. (2007)
  • 著者名/発表者名: Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura, Imai K, Hirohashi S, Yamada T
  • 雑誌名: C a n c e r R e s e a r c h 67(3) ページ: 911-918
  • 査読あり
• [雑誌論文] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. (2007)
  • 著者名/発表者名: Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
  • 雑誌名: C a n c e r S c i e n c e 98(1) ページ: 88-95
  • 査読あり
• [雑誌論文] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. (2007)
  • 著者名/発表者名: Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
  • 雑誌名: O n c o g e n e 26(32) ページ: 4699-4713
  • 査読あり
• [雑誌論文] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. (2007)
  • 著者名/発表者名: Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
  • 雑誌名: C a r c i n o - g e n e s i s 28(12) ページ: 2459-2466
  • 査読あり
• [雑誌論文] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. (2007)
  • 著者名/発表者名: K.Akino
  • 雑誌名: Cancer Science 98・1 ページ: 88-95
• [雑誌論文] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. (2007)
  • 著者名/発表者名: M.Nojima
  • 雑誌名: Oncogene (印刷中)
• [雑誌論文] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenine and T -cell factor-4-mediated gene transactivation : possible linkage of DNA damage recognition and Wnt signaling. (2007)
  • 著者名/発表者名: M.Idogawa
  • 雑誌名: Cancer Research 67・3 ページ: 911-918
• [雑誌論文] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • 著者名/発表者名: Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
  • 雑誌名: C a n c e r R e s e a r c h 66(9) ページ: 4574-83
  • 査読あり
• [雑誌論文] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • 著者名/発表者名: Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
  • 雑誌名: C a n c e r 106(7) ページ: 1467-1479
  • 査読あり
• [雑誌論文] Implications for gene therapy treatment of human glioblastomas. (2006)
  • 著者名/発表者名: Kang X, Xiao X, Harata M, Bai Y, Nakazaki Y, Soda Y, Kurita R, Tanaka T, Komine F, Izawa K, Kunisaki R, Setoyama M, Nishimori H, Natsume A, Sunamura M, Lozonshi L, Saitoh I, Tokino T, Asano S, Nakamura Y, Tani K: Antiangiogenic potency of BAI1 in vivo
  • 雑誌名: C a n c e r G e n e T h e r a p y 13(4) ページ: 385-392
  • 査読あり
• [雑誌論文] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinama. (2006)
  • 著者名/発表者名: Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada M, Tokino T, Shuinn T
  • 雑誌名: O n c o g e n e 25(12) ページ: 1733-1742
  • 査読あり
• [雑誌論文] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis (2006)
  • 著者名/発表者名: King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC
  • 雑誌名: C a r c i n o g e n e s i s 27(1) ページ: 53-63
  • 査読あり
• [雑誌論文] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. (2006)
  • 著者名/発表者名: Terasawa K, Toyota M, Sagae S, Ogi K, Suzuki H, Sonoda T, Akino K, Maruyama R, Nishikawa N, Imai K, Shinohara Y, Saito T, Tokino T
  • 雑誌名: B r J C a n c e r 94(6) ページ: 914-921
  • 査読あり
• [雑誌論文] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. (2006)
  • 著者名/発表者名: Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota Y, Tokino T, Itoh F, Imai K, Shinomura Y
  • 雑誌名: I n t J M o l M e d 18(1) ページ: 161-170
  • 査読あり
• [雑誌論文] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • 著者名/発表者名: R.Maruyama
  • 雑誌名: Cancer Research 66・9 ページ: 4574-4583
• [雑誌論文] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • 著者名/発表者名: M.Kusano
  • 雑誌名: Cancer 106・7 ページ: 1467-1479
• [雑誌論文] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines (2006)
  • 著者名/発表者名: K.Terasawa
  • 雑誌名: British J Cancer 94・6 ページ: 914-921
• [雑誌論文] Epigenetic inactivation of the candidate tumor suppressor gene HOXB 13 in human renal cell carcinama. (2006)
  • 著者名/発表者名: H.Okuda
  • 雑誌名: Oncogene 25・12 ページ: 1733-1742
• [雑誌論文] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. (2006)
  • 著者名/発表者名: T.Kobayashi
  • 雑誌名: Int J Molecular Medicine 18・1 ページ: 161-170
• [雑誌論文] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas. (2006)
  • 著者名/発表者名: X.Kang
  • 雑誌名: Cancer Gene Therapy 13・4 ページ: 385-392
• [雑誌論文] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. (2006)
  • 著者名/発表者名: K.E.King
  • 雑誌名: Carcinogenesis 27・1 ページ: 53-63
• [雑誌論文] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • 著者名/発表者名: Maruyama R et al.
  • 雑誌名: Cancer Research (印刷中)
• [雑誌論文] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma. (2006)
  • 著者名/発表者名: Okuda H et al.
  • 雑誌名: Oncogene 25・12 ページ: 1733-1742
• [雑誌論文] Genetic, epigenetic an clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • 著者名/発表者名: Kusano M et al.
  • 雑誌名: Cancer (印刷中)
• [雑誌論文] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. (2006)
  • 著者名/発表者名: King KE et al.
  • 雑誌名: Carcinogenesis (印刷中)
• [雑誌論文] Epigenetic inactivation of TCF2in ovarian cancer and various cancer cell lines. (2006)
  • 著者名/発表者名: Terasawa K et al.
  • 雑誌名: British J Cancer (印刷中)
• [雑誌論文] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas. (2006)
  • 著者名/発表者名: Kang X et al.
  • 雑誌名: Cancer Gene Therapy (印刷中)
• [雑誌論文] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes. (2005)
  • 著者名/発表者名: Sasaki Y, Naishiro Y, Oshima Y, Imai K, Nakamura Y, Tokino T
  • 雑誌名: O n c o g e n e 24(32) ページ: 5131-5136
  • 査読あり
• [雑誌論文] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer. (2005)
  • 著者名/発表者名: Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa J-P J, Hinoda Y, Imai K, Tokino T
  • 雑誌名: G a s t r o e n t e r o l o g y 129(1) ページ: 156-169
  • 査読あり
• [雑誌論文] Identification of laminin b3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. (2005)
  • 著者名/発表者名: Irifune H, Nishimori H, Watanabe G, Yoshida K, Ikeda T, Matsui C, Morohashi M, Kawaguchi S, Nagoya S, Wada T, Yamashita T, Nakamura Y, Tokino T
  • 雑誌名: C a n c e r B i o l o g y T h e r a p y 4(4) ページ: 449-455
  • 査読あり
• [雑誌論文] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors. (2005)
  • 著者名/発表者名: Ogi K, Toyota M, Mita H, Satoh A, Kashima L, Sasaki Y, Suzuki H, Akino K, Nishikawa N, Shinomura Y, Imai K, Hiratsuka H, Tokino T
  • 雑誌名: C a n c e r B i o l o g y T h e r a p y 4(7) ページ: 773-780
  • 査読あり
• [雑誌論文] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. (2005)
  • 著者名/発表者名: Simbulan-Rosethal CM, Trabosh V, Velarde A, Chou FP, Daher A, Tenzin F, Tokino T, Rosenthal DS
  • 雑誌名: O n c o g e n e 24(35) ページ: 5443-5458
  • 査読あり
• [雑誌論文] Upregulation of BNIP3 by 5-aza-2 ' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. (2005)
  • 著者名/発表者名: Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
  • 雑誌名: J G a s t r o e n t e r o l 40(5) ページ: 504-510
  • NAID: 10015648191
  • 査読あり
• [雑誌論文] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. (2005)
  • 著者名/発表者名: Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K
  • 雑誌名: B r J C a n c e r 92(6) ページ: 1165-1172
  • 査読あり
• [雑誌論文] Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (2005)
  • 著者名/発表者名: Odajima T, Sasaki Y, Tanaka N, Kato-Mori Y, Asanuma H, Ikeda T, Satoh M, Hiratsuka H, Tokino T, Sawada N
  • 雑誌名: H u m P a t h o l 36(3) ページ: 234-241
  • 査読あり
• [雑誌論文] The role of T-fimbrin in the response to DNA damage: Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents. (2005)
  • 著者名/発表者名: Ikeda H, Sasaki Y, Kobayashi T, Suzuki H, Mita H, Toyota M, Itoh F, Shinomura Y, Tokino T, Imai K
  • 雑誌名: I n t J O n c o l 27(4) ページ: 933-40
  • 査読あり
• [雑誌論文] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. (2005)
  • 著者名/発表者名: Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K
  • 雑誌名: C l i n i c a l C a n c e r R e s 11(3) ページ: 1021-1027
  • 査読あり
• [雑誌論文] Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. (2005)
  • 著者名/発表者名: Takemura K, Noguchi M, Ogi K, Tokino T, Kubota H, Miyazaki A, Kohama G, Horatsuka H
  • 雑誌名: J O r a l P a t h o l M e d 34(2) ページ: 93-99
  • 査読あり
• [雑誌論文] Tight junction proteinMAGi-1 is up-regulated by tranfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. (2005)
  • 著者名/発表者名: Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N
  • 雑誌名: C e l l T i s s u e R e s 319(2) ページ: 341-347
  • 査読あり
• [雑誌論文] A full genome scan for gastric cancer. (2005)
  • 著者名/発表者名: AokiM,YamamuraY,NoshiroH,SakaiK,YokotaJ,KohnoT,TokinoT,IshidaS,OhyamaS,NinomiyaI,UesakaK,KitajimaM,ShimadaS,MatsunoS,YanoM,HiratsukaM,SugimuraH,ItohF,MinamotoT,MaeharaY,TakenoshitaS,AikouT,KataiH,Yoshimura K, TakahashiT,AkagiK,SairenjiM,YamamotoK,SasazukiT
  • 雑誌名: J M e d i c a l G e n e t i c s 42(1) ページ: 83-87
  • 査読あり
• [雑誌論文] Identification of pigment epithelium derived actor as a direct target of the p53 family member genes. (2005)
  • 著者名/発表者名: Sasaki Y et al.
  • 雑誌名: Oncogene 24・32 ページ: 5131-5136
• [雑誌論文] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer. (2005)
  • 著者名/発表者名: Akino K et al.
  • 雑誌名: Gastroenterology 129・1 ページ: 156-169
• [雑誌論文] A full genome scan for gastric cancer. (2005)
  • 著者名/発表者名: Aoki M et al.
  • 雑誌名: J Medical Genetics 42・1 ページ: 83-87
• [雑誌論文] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. (2005)
  • 著者名/発表者名: Murai M et al.
  • 雑誌名: Clinical Cancer Research 11・3 ページ: 1021-1027
• [雑誌論文] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. (2005)
  • 著者名/発表者名: Simbulan-Rosenthal CM et al.
  • 雑誌名: Oncogene 24・35 ページ: 5443-5458
• [雑誌論文] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. (2005)
  • 著者名/発表者名: Murai M et al.
  • 雑誌名: British J Cancer 92・6 ページ: 1165-1172
• [雑誌論文] Small interfering RNA-induced CHFR silencing sensitizes oral aquamous cell cancer cells to microtuble inhibitors. (2005)
  • 著者名/発表者名: Ogi K et al.
  • 雑誌名: Cancer Biology Therapy 4・7 ページ: 773-780
• [雑誌論文] Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. (2005)
  • 著者名/発表者名: Irifune H et al.
  • 雑誌名: Cancer Biology Therapy 4・4 ページ: 449-455
• [雑誌論文] The role of T-fimbrin in the response to DNA damage : Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents. (2005)
  • 著者名/発表者名: Ikeda H et al.
  • 雑誌名: Int J Oncology 27・4 ページ: 933-940
• [雑誌論文] Abnormal beta-catenin expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (2005)
  • 著者名/発表者名: Odajima T et al.
  • 雑誌名: Human Pathology 36・3 ページ: 234-241
• [雑誌論文] Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line : cDNA micrroarray analysis. (2005)
  • 著者名/発表者名: Murata M et al.
  • 雑誌名: Cell Tissue Research 319・2 ページ: 341-347
• [雑誌論文] Upregulation of BNIP3 by 5-aza-2' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. (2005)
  • 著者名/発表者名: Abe T et al.
  • 雑誌名: J Gastroenterology 40・5 ページ: 504-510
• [雑誌論文] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
  • 著者名/発表者名: Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
  • 雑誌名: Breast Cancer Res Treat (in press)
  • 査読あり
• [学会発表] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2010)
  • 著者名/発表者名: Tokino T, Kashima L, Toyota M, Sasaki Y.
  • 学会等名: 101th American Association of Cancer Research (AACR) Annual Meeting
  • 発表場所: Washington DC, USA.
  • 年月日: 2010-04-20
• [学会発表] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer. (2010)
  • 著者名/発表者名: Tokino T, Idogawa M, Sasaki Y.
  • 学会等名: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
  • 発表場所: Hawaii, USA.
  • 年月日: 2010-02-09
• [学会発表] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer. (2010)
  • 著者名/発表者名: Tokino, Takashi
  • 学会等名: 8th Joint Conference of AACR and JCA
  • 発表場所: Hilton Waikoloa Village(米国)
  • 年月日: 2010-02-09
• [学会発表] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2010)
  • 著者名/発表者名: Kashima, Lisa, et al
  • 学会等名: 8th Joint Conference of AACR and JCA
  • 発表場所: Hilton Waikoloa Village(米国)
  • 年月日: 2010-02-08
• [学会発表] hCLCA2, a p53 inducible transmembrane protein,, regulates cancer cell migration and adhesion. (2010)
  • 著者名/発表者名: Sasaki, Yasushi, et al
  • 学会等名: 8th Joint Conference of AACR and JCA
  • 発表場所: Hilton Waikoloa Village(米国)
  • 年月日: 2010-02-07
• [学会発表] Identification and characterization of carly growth response gene-2 as a p53-regulated proapoptotic gene. (2010)
  • 著者名/発表者名: Yokota, Ikuko, et al
  • 学会等名: 8th Joint Conference of AACR and JCA
  • 発表場所: Hilton Waikoloa Village(米国)
  • 年月日: 2010-02-07
• [学会発表] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • 著者名/発表者名: Sasaki, Yasushi, et al
  • 学会等名: 米国癌学会年会
  • 発表場所: Colorado Convention Center(米国)
  • 年月日: 2009-04-21
• [学会発表] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • 著者名/発表者名: Idogawa Masashi, et al
  • 学会等名: 米国癌学会年会
  • 発表場所: Colorado Convention Center(米国)
  • 年月日: 2009-04-21
• [学会発表] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines (2008)
  • 著者名/発表者名: 時野隆至
  • 学会等名: 米国癌学会年会
  • 発表場所: 米国ロサンゼルス
  • 年月日: 2008-04-17
• [学会発表] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. (2008)
  • 著者名/発表者名: Tokino T, Sasaki Y.
  • 学会等名: 99th American Association of Cancer Research (AACR) Annual Meeting.
  • 発表場所: San Diego, USA.
  • 年月日: 2008-04-14
• [学会発表] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. (2007)
  • 著者名/発表者名: Tokino T, Oshima Y, Yamashita T, Sasaki Y.
  • 学会等名: 98th American Association of Cancer Research (AACR) Annual Meeting.
  • 発表場所: Los Angeles, USA.
  • 年月日: 2007-04-17
• [学会発表] Pigment epithelium derived factor as a direct target of the p53 family member genes. (2006)
  • 著者名/発表者名: Tokino T, Sasaki Y.
  • 学会等名: 97th American Association of Cancer Research (AACR) Annual Meeting.
  • 発表場所: Washington DC, USA.
  • 年月日: 2006-04-03
• [学会発表] Identification of laminin beta 3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumor. (2005)
  • 著者名/発表者名: Tokino T, Irifune H, Sasaki Y, Yoshida K, Kawaguchi S, Wada T, Yamashita T.
  • 学会等名: 96th American Association of Cancer Research (AACR) Annual Meeting.
  • 発表場所: Anaheim, USA.
  • 年月日: 2005-04-19
• [備考]
  • URL: http://web.sapmed.ac.jp/canmol/
• [備考]
  • URL: http://web.sapmed.ac.jp/canmol/index.html