疾患モデル動物を用いた多段階発がん研究:腎発がんの遺伝情報システム

• 研究課題/領域番号: 17013076
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 順天堂大学
• 研究代表者: 樋野 興夫 順天堂大学, 医学部, 教授 (90127910)
• 研究分担者: 小林 敏之 順天堂大学, 医学部, 准教授 (40260070) ; 梶野 一徳 順天堂大学, 医学部, 助教 (80260066) ; 百瀬 修二 順天堂大学, 医学部, 准教授 (70360344)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 48,500千円 (直接経費: 48,500千円); 2009年度: 9,700千円 (直接経費: 9,700千円); 2008年度: 9,700千円 (直接経費: 9,700千円); 2007年度: 9,700千円 (直接経費: 9,700千円); 2006年度: 9,700千円 (直接経費: 9,700千円); 2005年度: 9,700千円 (直接経費: 9,700千円)
• キーワード: 遺伝性がん / 癌化遺伝子 / 多段階発がん / 分子標的治療 / Niban遺伝子 / TSC遺伝子 / Bhd遺伝子 / ERC遺伝子 / 遺伝子発現

研究概要

遺伝性ラット(Tsc2およびBhd変異体)腎発がんの研究から、その過程で発見されたERC遺伝子が、ヒト「アスベスト・中皮腫」の診断・腫瘍マーカーの開発に進み、抗体治療を含めた、新規治療法の開発へと展開した。さらに、ヒト結節性硬化症の原因遺伝子産物であるtuberin(Tsc2産物)は、ラパマイシン感受性mTOR経路を抑制する機能を持つ。この経路の遮断による結節性硬化症の臨床治験が試みられているが、必ずしも著効を示す結果は得られていない。我々はtuberinの機能の全体像を明らかにした。新たな治療・予防法の標的となる経路の解明に資する。

研究成果

• [雑誌論文] Serine 62 is phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. (2010)
  • 著者名/発表者名: Wang L., Kobayashi T., Piao X., Shiono M., Takagi Y., Mineki R., Taka H., Zhang D., Abe M., Son G., Hagiwara Y., Okimoto K., Matsumoto I., Kouchi M., Hino O.
  • 雑誌名: FEBS Letters 584 ページ: 39-43
• [雑誌論文] Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia. (2010)
  • 著者名/発表者名: Ito S., Fujii H., Matsumoto T., Abe M., Ikeda K., Hino O.
  • 雑誌名: Head Neck 32 ページ: 96-103
• [雑誌論文] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization. (2010)
  • 著者名/発表者名: Inoue H., Uyama T., Suzuki T., Kazami M., Hino O., Kobayashi T., Kobayashi K., Tadokoro T.
  • 雑誌名: Biochem. Biophys. Res. Commun. 391 ページ: 1148-1153
• [雑誌論文] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model. (2010)
  • 著者名/発表者名: Kokubo T., Kakinuma S., Kobayashi T., Watanabe F., Iritani R., Tateno K., Nishimura M., Nishikawa T., Hino O., Shimada Y.
  • 雑誌名: Cancer Sci. 101 ページ: 616-623
  • NAID: 10026589138
• [雑誌論文] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo. (2010)
  • 著者名/発表者名: Inami K., Abe M., Takeda K., Hagiwara Y., Maeda M., Segawa T., Suyama M., Watanabe S., Hino O.
  • 雑誌名: Cancer Sci. 101 ページ: 969-974
  • NAID: 10026591120
• [雑誌論文] Serine 62 is phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. (2010)
  • 著者名/発表者名: Wang L., et al.
  • 雑誌名: FEBS Letters 584 ページ: 39-43
  • 査読あり
• [雑誌論文] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization. (2010)
  • 著者名/発表者名: Inoue H., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 391 ページ: 1148-1153
  • 査読あり
• [雑誌論文] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model. (2010)
  • 著者名/発表者名: Kokubo T., et al.
  • 雑誌名: Cancer Science 101 ページ: 616-623
  • 査読あり
• [雑誌論文] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature. (2010)
  • 著者名/発表者名: Kunogi M., et al.
  • 雑誌名: J.Med.Genetics (in press)
  • 査読あり
• [雑誌論文] Establishment of novel monoclonal antibody to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin-expressing cancers. (2009)
  • 著者名/発表者名: Ishikawa K., Segawa T., Hagiwara Y., Maeda M., Abe M., Hino O.
  • 雑誌名: Pathol. Int. 59 ページ: 161-166
• [雑誌論文] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. (2009)
  • 著者名/発表者名: Piao X., Kobayashi T., Wang L., Shiono M., Takagi Y., Sun G., Abe M., Hagiwara Y., Zhang D., Okimoto K., Kouchi M., Matsumoto I., Hino O.
  • 雑誌名: Biochem. Biophys. Res. Commun. 389 ページ: 16-21
• [雑誌論文] Establishment and chracterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat. (2009)
  • 著者名/発表者名: Matsumoto I., Kouchi M., Okimoto K., Kijima K., Ueda T., Hirayama Y., Inoue T., Hino O.
  • 雑誌名: Tumor Biology 30 ページ: 249-256
• [雑誌論文] An animal model of precilinical diagnosis of pancreatic ductal carcinomas. (2009)
  • 著者名/発表者名: Fukamachi K., Tanaka H., Hagiwara Y., Ohara H., Joh T., Iigo M., Alexander D.B., Xu J., Long N., Takigahira M., Yonagihara K., Hino O., Saito I.
  • 雑誌名: Biochem. Biophys. Res. Commun. 390 ページ: 636-641
• [雑誌論文] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. (2009)
  • 著者名/発表者名: Piao X., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 389 ページ: 16-21
  • 査読あり
• [雑誌論文] Establishment and chracterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat. (2009)
  • 著者名/発表者名: Matsumoto I., et al.
  • 雑誌名: Tumor Biology 30 ページ: 249-256
  • 査読あり
• [雑誌論文] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Racl activation. (2008)
  • 著者名/発表者名: Suzuki T., Das S.K., Inoue H., Kazami M., Hino O., Kobayashi T., Yeung R.S., Kobayashi K., Tadokoro T., Yamamoto Y.
  • 雑誌名: Biochem. Biophys. Res. Commun 368 ページ: 132-137
• [雑誌論文] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma. (2008)
  • 著者名/発表者名: Shiomi K., Hagiwara Y., Sonoue K., Segawa T., Miyashita K., Maeda M., Izumi H., Masuda K., Hirabayashi M., Moroboshi T., Yoshiyama T., Ishida A., Natori Y., Inoue A., Kobayashi M., Sakao Y., Miyamoto H., Takahashi K., Hino O.
  • 雑誌名: Clinical Cancer Res. 14 ページ: 1431-1437
• [雑誌論文] Mesomark kit detects C-ERC/mesothelin, but not SMRP with C-terminus. (2008)
  • 著者名/発表者名: Segawa T., Hagiwara Y., Ishikawa K., Aoki N., Maeda M., Shiomi K., Hino O.
  • 雑誌名: BBRC 369 ページ: 915-918
• [雑誌論文] Diagnostic tumor marker of asbestos-related messoth. (2008)
  • 著者名/発表者名: Hino O., Maeda, M.
  • 雑誌名: Environmental Health and Preventive Medicine 13 ページ: 71-74
• [雑誌論文] siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model. (2008)
  • 著者名/発表者名: Imamura O., Okada H., Takashima Y., Zhang D., Kobayashi T., Hino O.
  • 雑誌名: Cancer Letters 268 ページ: 278-285
• [雑誌論文] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein. (2008)
  • 著者名/発表者名: Takagi Y., Kobayashi, T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O.
  • 雑誌名: Oncogene 27 ページ: 5339-5347
• [雑誌論文] Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. (2008)
  • 著者名/発表者名: Inami K., Kajino K., Abe M., Hgiwara Y., Maeda M., Suyama M., Watanabe S., Hino O.
  • 雑誌名: Oncology Reports 20 ページ: 1375-1380
• [雑誌論文] Establishment of a Novel Specific ELISA system for rat N- and C-ERC/Mesothelin. -Rat ERC/Mesothelin in the body fluids of mice bearing mesothelioma-. (2008)
  • 著者名/発表者名: Hagiwara Y., Hamada Y., Kuwahara M., Maeda M., Segawa T., Ishikawa K., Hino O.
  • 雑誌名: Cancer Sci. 99 ページ: 666-670
  • NAID: 10024004555
• [雑誌論文] Biphasic response of pancreatic β cell mass to ablation of TSC2 mice. (2008)
  • 著者名/発表者名: Shigeyama Y., Kobayashi T., Kido Y., Hashimoto N., Asahara S., Matsuda T., Takeda A., Inoue T., Shibutani Y., Koyanagi M., Uchida T., Inoue M., Hino O., Kasuga M., Noda T.
  • 雑誌名: Mol. Cell. Biology 28 ページ: 2971-2979
• [雑誌論文] The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition. (2008)
  • 著者名/発表者名: Shiono M., Kobayashi T., Takahashi R., Sun G., Abe M., Zhang D., Wang L., Piao X., Takagi Y., Mineki R., Taka H., Tada N., Sonobe S., Momose S., Ueda M., Hino O.
  • 雑誌名: Oncogene 27 ページ: 6690-6697
• [雑誌論文] ERC/mesothelin as a marker for chemotherapeutic response in patients with mesothelioma. (2008)
  • 著者名/発表者名: Tajima K., Hirama M., Shiomi K, Ishiwata T., Yoshioka M., Iwase A., Iwakami S., Yamazaki M., Toba M., Tobino K., Sugano K., Ichikawa M., Hagiwara Y., Takahashi K., Hino O.
  • 雑誌名: Anticancer Research 28 ページ: 3933-3936
• [雑誌論文] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential ans a useful serum tumor marker for mesothelioma (2008)
  • 著者名/発表者名: Shiomi K., et.al.
  • 雑誌名: Clinical Cancer Res 14 ページ: 1431-1437
  • 査読あり
• [雑誌論文] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein (2008)
  • 著者名/発表者名: Takagi Y., et.al.
  • 雑誌名: Oncogene 27 ページ: 5339-5347
  • 査読あり
• [雑誌論文] The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition (2008)
  • 著者名/発表者名: Shiono M., et.al.
  • 雑誌名: Oncogene 27 ページ: 6690-6697
  • 査読あり
• [雑誌論文] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Racl actlvatlon. (2008)
  • 著者名/発表者名: Suzuki, T., et. al.
  • 雑誌名: BBRC 368 ページ: 132-137
  • 査読あり
• [雑誌論文] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma. (2008)
  • 著者名/発表者名: Shiomi, K., et. al.
  • 雑誌名: Chnical Cancer Res 14 ページ: 1431-1437
  • 査読あり
• [雑誌論文] Postoperative fibromatosis-type fibromas in the Bhdgene mutant (Nihon) rat. (2008)
  • 著者名/発表者名: Kouchi, M., et. al.
  • 雑誌名: Exp Toxicol Pathology (in press)
  • 査読あり
• [雑誌論文] Establishment of a Novel Specific ELISA system for rat N-and C-ERC/Mesothelin.-Rat ERC/Mesothelin in the Body Fluids of mice bearing Mesothelioma- (2008)
  • 著者名/発表者名: Hagiwara, Y., et. al.
  • 雑誌名: Cancer Science (in press)
  • 査読あり
• [雑誌論文] Biphasic response of pancreatic β cell mass to ablation of TSC2 mice. (2008)
  • 著者名/発表者名: Shigeyama, Y., et. al.
  • 雑誌名: Mol. Cell. Biology (in press)
  • 査読あり
• [雑誌論文] Mesomark kit detects C-ERC/mesothelin, but not SMRP with C-terminus. (2008)
  • 著者名/発表者名: Segawa, T., et. al.
  • 雑誌名: BBRC (in press)
  • 査読あり
• [雑誌論文] GADD34 inhibits mammalian target of repamycin signaling via tuberous sclerosis complex and controls cell surbival under bioenergetic stress. (2007)
  • 著者名/発表者名: Watanabe R., Tambe Y., Inoue H., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T.
  • 雑誌名: Int. J. Molecular Medicine 19 ページ: 475-483
• [雑誌論文] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo N-terminal hamartin-binding and C-termin. (2007)
  • 著者名/発表者名: Momose S., Kobayashi T., Tada N., Itoyama S., Hino O.
  • 雑誌名: Biochem. Biophys. Res. Commun 356 ページ: 693-698
• [雑誌論文] The endoplasmic reticulum stress-inducible protein Niban regulates eIF2 α and S6K1/4E-BP1 phosphorylation. (2007)
  • 著者名/発表者名: Sun G.D., Kobayashi T., Abe M., Tada N., Adachi H., Shiota A., Totsuka Y., Hino O.
  • 雑誌名: Biochem. Biophys. Res. Commun 360 ページ: 181-187
• [雑誌論文] Birt-Hogg-Dube (BHD) gene mutations in human gastric cancer with high hrequency microsatellite instability. (2007)
  • 著者名/発表者名: Jiang W., Fujii H., Matsumoto T., Ohtsuji N., Tsurumaru M., Hino O.
  • 雑誌名: Cancer Letter 248 ページ: 103-111
• [雑誌論文] Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/ Mesothelin. (2007)
  • 著者名/発表者名: Nakaishi M., Kajino K., Ikesue M., Hagiwara Y., Kuwahara M., Mitani H., Horikoshi Y., Segawa T., Kon S., Maeda M., Baiyin T., Abe M., Yokoyama M., Hino O.
  • 雑誌名: Cancer Sci. 98 ページ: 659-664
• [雑誌論文] A diagnostic biomarker of Asbestos-related mesothelioma-Example of translational research-. (2007)
  • 著者名/発表者名: Hino O., Shiomi K., Maeda M.
  • 雑誌名: Cancer Sci. 98 ページ: 1147-1157
• [雑誌論文] Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway. (2007)
  • 著者名/発表者名: Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H.
  • 雑誌名: J. Virology 81 ページ: 11106-11115
• [雑誌論文] GADD34 inhibits mammalian target of repamycin signaling via tuberous sclerosis complex and controls cell surbival under bioenergetic stress. (2007)
  • 著者名/発表者名: Watanabe, R., et. al.
  • 雑誌名: Int. J. Molecular Medicine 19 ページ: 475-483
  • 査読あり
• [雑誌論文] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo N-terminal hamartin-binding and C-termin. (2007)
  • 著者名/発表者名: Momose, S., et. al.
  • 雑誌名: Biochemical and Biophysical Research Communications 356 ページ: 693-698
  • 査読あり
• [雑誌論文] The endoplasmic reticulum stress-inducible protein Niban regulates eIF2α and S6K1/4E-BP1 phosphorylation. (2007)
  • 著者名/発表者名: Sun, G.D., et. al.
  • 雑誌名: BBRC 360 ページ: 181-187
  • 査読あり
• [雑誌論文] Birt-Hogg-Dube (BHD) gene mutations in human gastic cancer with high hrequency microsatellite instability. (2007)
  • 著者名/発表者名: Jiang, W., et. al.
  • 雑誌名: Cancer Letter 248 ページ: 103-111
  • 査読あり
• [雑誌論文] Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/Mesothelin. (2007)
  • 著者名/発表者名: Nakanishi, M., et. al.
  • 雑誌名: Cancer Science 98 ページ: 659-664
  • 査読あり
• [雑誌論文] A diagnostic biomarker of Asbestos-related mesothelioma-Example of translational research- (2007)
  • 著者名/発表者名: Hino, O., et. al.
  • 雑誌名: Cancer Science 98 ページ: 1147-1157
  • 査読あり
• [雑誌論文] Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway. (2007)
  • 著者名/発表者名: Minami, K., et. al.
  • 雑誌名: J. Virology 81 ページ: 11106-11115
  • 査読あり
• [雑誌論文] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. (2006)
  • 著者名/発表者名: Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
  • 雑誌名: Oncogene 25 ページ: 2885-2889
• [雑誌論文] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome. (2006)
  • 著者名/発表者名: Kouchi M., Okimoto K., Matsumoto I., Tanaka K., Yasuba M., Hino O.
  • 雑誌名: Virchow Archives 448 ページ: 463-471
• [雑誌論文] Novel ELISA system for detection of "N-ERC/mesothelin" in the sera of mesothelioma patients. (2006)
  • 著者名/発表者名: Shiomi K., Miyamoto H., Segawa T., Hagiwara Y., Ota A., Maeda M., Takahashi K., Masuda K., Sakao Y., Hino O.
  • 雑誌名: Cancer Sci 97 ページ: 928-932
  • NAID: 10018767738
• [雑誌論文] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis. (2006)
  • 著者名/発表者名: Matsumoto F., Fujii H., Abe M., Kajino K., Kobayashi T., Matsumoto T., Ikeda K., Hino O.
  • 雑誌名: Human Pathology 37 ページ: 1592-1600
• [雑誌論文] Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation. (2006)
  • 著者名/発表者名: Chano T., Saji M., Inoue H., Minami K., Kobayashi T., Hino O., Okabe H.
  • 雑誌名: Int. J. Molecular Medicine 18 ページ: 425-432
• [雑誌論文] Intraction of Fox01 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway. (2006)
  • 著者名/発表者名: Cao Y., Kamioka Y., Yokoi N., Kobayashi T., Hino O., Onodera M., Mochizuki N., Nakae J.
  • 雑誌名: J. Biological Chemistry 281 ページ: 40242-40251
• [雑誌論文] Blood tests for Asbestos-related mesothelioma. (2006)
  • 著者名/発表者名: Maeda M., Hino O.
  • 雑誌名: Oncology 71 ページ: 26-31
• [雑誌論文] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. (2006)
  • 著者名/発表者名: Togashi Y, Kobayashi T, Momose S, et al.
  • 雑誌名: Oncogene 25 ページ: 2885-2889
• [雑誌論文] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome. (2006)
  • 著者名/発表者名: Kouchi M., Okimoto K., Matsumoto I., et al.
  • 雑誌名: Virchow Archives 448 ページ: 463-471
• [雑誌論文] Novel ELISA system for detection of "N-ERC/mesothelin" in the sera of mesothelioma patients. (2006)
  • 著者名/発表者名: Shiomi K., Miyamoto H., Segawa T., et al.
  • 雑誌名: Cancer Science 97 ページ: 928-932
• [雑誌論文] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis. (2006)
  • 著者名/発表者名: Matsumoto F., Fujii H., Abe M., et al.
  • 雑誌名: Human Pathology 37 ページ: 1592-1600
• [雑誌論文] Intraction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway. (2006)
  • 著者名/発表者名: Cao Y., Kamioka Y., Yokoi N., et al.
  • 雑誌名: J. Biological Chemistry 281 ページ: 40242-40251
• [雑誌論文] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. (2005)
  • 著者名/発表者名: Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
  • 雑誌名: Cancer Res 65 ページ: 203-209
• [雑誌論文] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor. (2005)
  • 著者名/発表者名: Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O., Cordon-Cardo C., Pandolfi P.P.
  • 雑誌名: Genes & Development 19 ページ: 1779-1986
• [雑誌論文] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. (2005)
  • 著者名/発表者名: Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
  • 雑誌名: Cancer Research 65 ページ: 203-209
• [雑誌論文] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor. (2005)
  • 著者名/発表者名: Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O.et al.
  • 雑誌名: Genes & Development 19 ページ: 1779-1986
• [雑誌論文] Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis. (2005)
  • 著者名/発表者名: Hino O.
  • 雑誌名: Intervirology 48 ページ: 6-9
• [雑誌論文] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.
  • 著者名/発表者名: Kunogi M., Kurihara M., Shigihara-Ikegami T., Kobayashi T., Shindo N., Kumasaka T., Gunji Y., Kikkawa M., Iwakami S., Hino O., Takahashi K., Seyama K.
  • 雑誌名: J. Med. Genetics (in press)
• [雑誌論文] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in mesothelioma mouse model.
  • 著者名/発表者名: Yoshida C., Sogawa C., Tsuji A., Sudo H., Sugyo A., Uehara T., Hino O., Yoshii Y., Fujibayashi Y., Fukumura T., Koizumi M., Arano Y., Saga T.
  • 雑誌名: Nuclear Medicine Communications (in press)
• [雑誌論文] Establishment of the ELISA system to detect the amino terminal secretorv form of rat Erc/Mesothelin
  • 著者名/発表者名: Nakanishi M., Kajino K., Ikesue M., et al.
  • 雑誌名: Cancer Science (In press)
• [雑誌論文] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.
  • 著者名/発表者名: Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
  • 雑誌名: Oncogene (in press)
• [雑誌論文] Gene Expression Profile of dbpA (DNA Binding Protein A) transgenic mice.
  • 著者名/発表者名: Tobita H, Kajino K, Inami K, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O.
  • 雑誌名: Int.J.Oncology (in press)
• [雑誌論文] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome.
  • 著者名/発表者名: Kouchi M., Okimoto K., Matsumoto I., Tanaka K., Yasuba M., Hino O.
  • 雑誌名: Virchow Archives (in press)
• [図書] Models for genitourinary cancer-Hereditary renal carcinogenesis. The CANCER handbook. Second edition. (2007)
  • 著者名/発表者名: Hino, O.
  • 出版者: WILEY
• [図書] Cancer : Cell Structures, Carcinogens and Genomic Instability. (2006)
  • 著者名/発表者名: Hino O., Kobayashi T., Okimoto K.
  • 総ページ数: 24
  • 出版者: Birkhauser Verlag
• [図書] Cancer : Cell Structures, Carinogenes and Genomic Instability. (2005)
  • 著者名/発表者名: Hino O., Kobayashi T., Okimoto K.
  • 出版者: Birkhauser Verlag
• [産業財産権] 中皮種診断剤、中皮種診断キットおよび中皮種診断方法
  • 発明者名: 樋野興夫、清藤勉
  • 権利者名: 株式会社免疫生物研究所
  • 産業財産権番号: 2006-331409