ストレス応答シグナルによるがん細胞の増殖・死の制御

• 研究課題/領域番号: 17014013
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京大学
• 研究代表者: 一條 秀憲 東京大学, 大学院・薬学系研究科, 教授 (00242206)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 55,000千円 (直接経費: 55,000千円); 2009年度: 12,800千円 (直接経費: 12,800千円); 2008年度: 12,800千円 (直接経費: 12,800千円); 2007年度: 9,800千円 (直接経費: 9,800千円); 2006年度: 9,800千円 (直接経費: 9,800千円); 2005年度: 9,800千円 (直接経費: 9,800千円)
• キーワード: ASK1 / ASK2 / MAPキナーゼ / アポトーシス / ASKファミリー / ASKI

研究概要

本研究は、がん細胞における異常増殖ならびに細胞死耐性のメカニズムをストレス応答シグナル伝達経路の破綻という観点から解析することを目的として行った。具体的には、ストレス感受性MAPキナーゼ系分子群としてのASKファミリーの機能解析を軸に、ノックアウトマウスの作製ならびに発がん性の解析を行い、ストレス感受性MAPキナーゼスーパーファミリーが、がんの発生・進展において果たす役割を明らかにした。

研究成果

• [雑誌論文] Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. (2010)
  • 著者名/発表者名: Seong, H.A., Jung, H., Ichijo, H., Ha, H.
  • 雑誌名: J. Biol. Chem. 285 ページ: 2397-2414
• [雑誌論文] Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1(ASK1)-deficient mice (2010)
  • 著者名/発表者名: Kumakura, K., et al.
  • 雑誌名: Neurosci.Res. 66 ページ: 313-320
  • 査読あり
• [雑誌論文] Apoptosis Signal-Regulating Kinase 1 regulates colitis and colitis-associated tumorigenesis via the innate immune responses (2010)
  • 著者名/発表者名: Hayakawa, Y., et al.
  • 雑誌名: Gastroenterology 138 ページ: 1055-1067
  • 査読あり
• [雑誌論文] Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation (2010)
  • 著者名/発表者名: Seong, H.A., et al.
  • 雑誌名: J.Biol.Chem. 285 ページ: 2397-2414
  • 査読あり
• [雑誌論文] Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. (2009)
  • 著者名/発表者名: Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H., d Mitchell, T.C.
  • 雑誌名: J. Biol. Chem. 284 ページ: 31982-31991
• [雑誌論文] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. (2009)
  • 著者名/発表者名: Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., Ichijo, H.
  • 雑誌名: Mol. Cell 36 ページ: 805-818
• [雑誌論文] TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. (2009)
  • 著者名/発表者名: Kundu M, Pathak SK, Kumawat K, Basu S, Chatterjee G, Pathak S, Noguchi T, Takeda K, Ichijo, H, Thien CB, Langdon WY, Basu J. A
  • 雑誌名: Nat. Immunol. 10 ページ: 918-926
• [雑誌論文] Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (2009)
  • 著者名/発表者名: Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., Ichijo, H.
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 106 ページ: 12301-12305
• [雑誌論文] Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death. (2009)
  • 著者名/発表者名: Zhou, J., Shao, Z., Kerkela, R., Ichijo, H., Muslin, A., Pombo, C., Force, T.
  • 雑誌名: Mol. Cell. Biol. 29 ページ: 4167-4176
• [雑誌論文] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (2009)
  • 著者名/発表者名: Waak, J., Weber, S.S., Gorner, K., Schall, C., Ichijo, H., Stehle, T., Kahle, P.J.
  • 雑誌名: J. Biol. Chem. 284 ページ: 14245-14257
• [雑誌論文] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • 著者名/発表者名: Iriyama, T., Takeda, K., Nakamura, H.,Morimoto, Y., Kuroiwa, T., Mizukami, J.,Umeda, T., Noguchi, T., Naguro, I.,Nishitoh, H., Saegusa, K., Tobiume, K.,Homma, T., Shimada, Y., Tsuda, H., Aiko, S.,Imoto, I., Inazawa, J., Chida, K., Kamei, Y.,Kozuma, S., Taketani, Y., Matsuzawa, A., Ichijo, H.
  • 雑誌名: EMBO J. 28 ページ: 843-853
• [雑誌論文] Apoptosis Signal-Regulating Kinase(ASK)-1 Mediates Apoptosis through activation of JNK1 following Engagement of Membrane Immunoglobulin (2009)
  • 著者名/発表者名: Furuhata, M.
  • 雑誌名: Exp.Cell.Res. 315 ページ: 3467-3476
  • 査読あり
• [雑誌論文] Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A (2009)
  • 著者名/発表者名: Cekic, C., et al.
  • 雑誌名: J.Biol.Chem. 284 ページ: 31982-31991
  • 査読あり
• [雑誌論文] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death (2009)
  • 著者名/発表者名: Nagai, H, et al.
  • 雑誌名: Mol.Cell 36 ページ: 805-818
  • 査読あり
• [雑誌論文] A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis (2009)
  • 著者名/発表者名: Kundu M, et al.
  • 雑誌名: Nat.Immunol. 10 ページ: 918-926
  • 査読あり
• [雑誌論文] Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis (2009)
  • 著者名/発表者名: Nakamura, T., et al.
  • 雑誌名: Hypertension 54 ページ: 544-551
  • 査読あり
• [雑誌論文] Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1 (2009)
  • 著者名/発表者名: Takeda, K., et al.
  • 雑誌名: Proc.Natl.Acad.Sci.USA. 13 ページ: 653-664
  • 査読あり
• [雑誌論文] Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death (2009)
  • 著者名/発表者名: Zhou, J., et al.
  • 雑誌名: Mol.Cell.Biol. 29 ページ: 4167-4176
  • 査読あり
• [雑誌論文] Targeting ASK1 in ER stress-related Neurodegenerative Diseases (2009)
  • 著者名/発表者名: Homma, K., et al.
  • 雑誌名: Expert Opinion on Therapeutic Targets 13 ページ: 653-664
  • 査読あり
• [雑誌論文] Signaling pathways in invertebrate immune and stress response (2009)
  • 著者名/発表者名: Hatanaka, R., et al.
  • 雑誌名: Invertebrate Survival Journal 6 ページ: 32-43
  • 査読あり
• [雑誌論文] The roles of ASK family proteins in stress responses and diseases (2009)
  • 著者名/発表者名: Hattori, K., et al.
  • 雑誌名: Cell Communication and Signaling 7 ページ: 9-9
  • 査読あり
• [雑誌論文] Stress-Activated MAP Kinase Cascades in Cellular Senescence (2009)
  • 著者名/発表者名: Maruyama, J., et al.
  • 雑誌名: Curr.Med.Chem. 16 ページ: 1229-1235
  • 査読あり
• [雑誌論文] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009)
  • 著者名/発表者名: Galluzzi, L., et al.
  • 雑誌名: Cell Death Differ. 16 ページ: 1093-1107
  • 査読あり
• [雑誌論文] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase1 (2009)
  • 著者名/発表者名: Waak, J., et al
  • 雑誌名: J.Biol.Chem. 284 ページ: 14245-14257
  • 査読あり
• [雑誌論文] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • 著者名/発表者名: Iriyama, T., et al.
  • 雑誌名: EMBO J. 28 ページ: 843-853
  • 査読あり
• [雑誌論文] USP14 inhibits ER-associated degradation via interaction with IRE1 alpha (2009)
  • 著者名/発表者名: Nagai, A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 379 ページ: 995-1000
  • 査読あり
• [雑誌論文] Signaling pathways in invertebrate immune and stress response (2009)
  • 著者名/発表者名: Hatanaka, R., et.al.
  • 雑誌名: Invertebrate Survival Journal 6 ページ: 32-43
  • 査読あり
• [雑誌論文] The roles of ASK family proteins in stress responses and diseases (2009)
  • 著者名/発表者名: Hattori, K., et.al.
  • 雑誌名: Cell Communication and Signaling (In press)
  • 査読あり
• [雑誌論文] Stress-Activated MAP Kinase Cascades in Cellular Senescence (2009)
  • 著者名/発表者名: Maruyama, J., et.al.
  • 雑誌名: Curr. Med. Chem. 16 ページ: 1229-1235
  • 査読あり
• [雑誌論文] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009)
  • 著者名/発表者名: Galluzzi, L., et.al.
  • 雑誌名: Cell Death Differ. (In press)
  • 査読あり
• [雑誌論文] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1 (2009)
  • 著者名/発表者名: Waak, J., et.al.
  • 雑誌名: J. Biol. Chem. (In press)
  • 査読あり
• [雑誌論文] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • 著者名/発表者名: Iriyama, T., et.al.
  • 雑誌名: EMBO J. 28 ページ: 843-853
  • 査読あり
• [雑誌論文] USP14 inhibits ER-associated degradation via interaction with IRE1a 1pha (2009)
  • 著者名/発表者名: Nagai, A., et.al.
  • 雑誌名: Biochem. Biophys. Res. Commun. 379 ページ: 995-1000
  • 査読あり
• [雑誌論文] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. (2008)
  • 著者名/発表者名: Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo, H.
  • 雑誌名: Genes Dev. 22 ページ: 1451-1464
• [雑誌論文] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. (2008)
  • 著者名/発表者名: Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., Ichijo, H.
  • 雑誌名: J. Biol. Chem. 283 ページ: 7657-7665
• [雑誌論文] Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun n-terminal kinase activation (2008)
  • 著者名/発表者名: Nakagawa, H., et.al.
  • 雑誌名: Gastroenterology 135 ページ: 1047-1051
  • 査読あり
• [雑誌論文] Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by Apoptosis Signal regulating Kinase-1 inhibition (2008)
  • 著者名/発表者名: Yamamoto, E., et.al.
  • 雑誌名: Hypertension 52 ページ: 573-580
  • 査読あり
• [雑誌論文] Molecular Mechanism of Reactive Oxygen Species-dependent ASKI Activation in Innate Immunity (2008)
  • 著者名/発表者名: Yamauchi, S., et.al.
  • 雑誌名: Immune Network 8 ページ: 1-6
  • 査読あり
• [雑誌論文] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 (2008)
  • 著者名/発表者名: Nishitoh, H., et.al.
  • 雑誌名: Genes Dev. 22 ページ: 1451-1464
  • 査読あり
• [雑誌論文] Requirement of reactive oxygen species-dependent activation of ASK 1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macronhage (2008)
  • 著者名/発表者名: Noguchi, T., et.al.
  • 雑誌名: J. Biol. Chem. 283 ページ: 7657-7665
  • 査読あり
• [雑誌論文] Redox control of cell fate by MAP kinase : physiological roles of ASK1-MAP kinase pathway in stress signaling (2008)
  • 著者名/発表者名: Matsuzawa, A., et.al.
  • 雑誌名: Biochim. Biophys. Acta. 1780 ページ: 1325-1336
  • 査読あり
• [雑誌論文] Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death (2008)
  • 著者名/発表者名: Wu, Y., et.al.
  • 雑誌名: Cell Death Differ. 15 ページ: 386-397
  • 査読あり
• [雑誌論文] Apoptosis signal-regulating kinase 1 (ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy (2008)
  • 著者名/発表者名: Taniike, M., et.al.
  • 雑誌名: Circulation 117 ページ: 545-552
  • 査読あり
• [雑誌論文] Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response (2008)
  • 著者名/発表者名: Takeda, K., et.al.
  • 雑誌名: Annu. Rev. Pharmacol. Toxicol. 48 ページ: 199-225
  • 査読あり
• [雑誌論文] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. (2008)
  • 著者名/発表者名: Noguchi, T., et. al.
  • 雑誌名: J. Biol. Chem. 283 ページ: 7657-7665
  • 査読あり
• [雑誌論文] Apoptosis Signal-regulating kinase l (ASK1) in stress and immune response. (2008)
  • 著者名/発表者名: Takeda, K., et. al.
  • 雑誌名: Annu. Rev. Pharmacol. Toxicol. 48 ページ: 199-225
  • 査読あり
• [雑誌論文] Apoptosis signal-regulating kinase 1 (ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy. (2008)
  • 著者名/発表者名: Taniike, M., et. al.
  • 雑誌名: Circulation 117 ページ: 545-552
  • 査読あり
• [雑誌論文] Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. (2008)
  • 著者名/発表者名: Wu, Y. T., et. al.
  • 雑誌名: Cell Death Differ. 15 ページ: 386-397
  • 査読あり
• [雑誌論文] Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling (2008)
  • 著者名/発表者名: Matsuzawa A., et. al.
  • 雑誌名: Biochim. Biophys. Acta. special issue Redox Control of Cell Function (掲載確定)
  • 査読あり
• [雑誌論文] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (2007)
  • 著者名/発表者名: Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K., Ichijo, H.
  • 雑誌名: Mol. Cell. Biol. 27 ページ: 8152-8163
• [雑誌論文] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. (2007)
  • 著者名/発表者名: Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K., Ichijo, H.
  • 雑誌名: J. Cell Biol. 176 ページ: 903-909
• [雑誌論文] Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. (2007)
  • 著者名/発表者名: Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., Ichijo, H.
  • 雑誌名: J. Biol. Chem. 282 ページ: 7522-7531
• [雑誌論文] Stress signaling in cancer. (2007)
  • 著者名/発表者名: Murakami, S., et. al.
  • 雑誌名: Cancer Sci. 98 ページ: 1521-1527
  • 査読あり
• [雑誌論文] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (2007)
  • 著者名/発表者名: Fujino, G., et. al.
  • 雑誌名: Mol. Cell. Biol. 27 ページ: 8152-8163
  • 査読あり
• [雑誌論文] ASK family proteins in stress response and disease. (2007)
  • 著者名/発表者名: Fujisawa, T., et. al.
  • 雑誌名: Mol. Biotechnol. 27 ページ: 8152-8163
  • 査読あり
• [雑誌論文] Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1. (2007)
  • 著者名/発表者名: Kuwamura, H., et. al.
  • 雑誌名: Oncol Rep. 17 ページ: 781-786
  • 査読あり
• [雑誌論文] ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a egative role in induction of apoptosis. (2007)
  • 著者名/発表者名: Yan, W., et. al.
  • 雑誌名: Biochem. Biophys. Res. Commun. 355 ページ: 1038-1044
  • 査読あり
• [雑誌論文] Regulation of Apoptosis Signal-regulating Kinase 1 by Protein Phosphatase 2Cε. (2007)
  • 著者名/発表者名: Saito, J., et. al.
  • 雑誌名: Biochem. J. 405 ページ: 591-596
  • 査読あり
• [雑誌論文] Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling. (2007)
  • 著者名/発表者名: Kani, S., et. al.
  • 雑誌名: Genes Cells 12 ページ: 919-928
  • 査読あり
• [雑誌論文] Apoptosis Signal-regulating Kinase-1 is involved in vascular endothelial and cardiac remodeling caused by nitric oxide deficiency. (2007)
  • 著者名/発表者名: Yamashita, T., et. al.
  • 雑誌名: Hypertension. 50 ページ: 519-524
  • 査読あり
• [雑誌論文] Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. (2007)
  • 著者名/発表者名: Galvan V., et. al.
  • 雑誌名: Neurobiol Dis. 28 ページ: 65-75
  • 査読あり
• [雑誌論文] Novel Mechanism and Role of Angiotensin II-Induced Vascular Endothelial Injury in Hypertensive Diastolic Heart Failure. (2007)
  • 著者名/発表者名: Yamamoto, E., et. al.
  • 雑誌名: Arterioscler. Thromb. Vasc. Biol. 27 ページ: 2569-2575
  • 査読あり
• [雑誌論文] Critical roles of the apoptosis signal-regulating kinase 1 and NADPH oxidase subunit p47phox for tuberculin PPD/Toll-like receptor 2-mediated inflammatory signaling during human tuberculosis. (2007)
  • 著者名/発表者名: Yang, C.-S., et. al.
  • 雑誌名: Cell. Microbiol. 10 ページ: 741-754
  • 査読あり
• [雑誌論文] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. (2007)
  • 著者名/発表者名: Terada, Y., et. al.
  • 雑誌名: Biochem. Biophys. Res. Commun. 364 ページ: 1043-1049
  • 査読あり
• [雑誌論文] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. (2007)
  • 著者名/発表者名: Osaka, N. et al.
  • 雑誌名: J. Cell Biol. 176 ページ: 903-909
• [雑誌論文] Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. (2007)
  • 著者名/発表者名: Takeda, K. et al.
  • 雑誌名: J. Biol. Chem. 282 ページ: 7522-7531
• [雑誌論文] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2007)
  • 著者名/発表者名: Kitagawa, D. et al.
  • 雑誌名: EMBO J. 25 ページ: 3286-3297
• [雑誌論文] Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways. (2007)
  • 著者名/発表者名: Nagai, H. et al.
  • 雑誌名: J. Biochem. Mol. Biol. 40 ページ: 1-6
• [雑誌論文] GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial parkinson's disease. (2007)
  • 著者名/発表者名: Ito, G.et al.
  • 雑誌名: Biochemistry 46 ページ: 1380-1388
• [雑誌論文] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2006)
  • 著者名/発表者名: Kitagawa, D., Kajiho, H., Negishi, T., Ura, S., Watanabe, T., Wada, T., Ichijo, H., Katada, T., Nishina, H.
  • 雑誌名: Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J. 25 ページ: 3286-3297
• [雑誌論文] Apoptosis- regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. (2006)
  • 著者名/発表者名: Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H., David, M.
  • 雑誌名: J. Immunol. 176 ページ: 5720-5724
• [雑誌論文] Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. (2006)
  • 著者名/発表者名: Liu, Q., Wilkins, B.J., Lee, Y.J., Ichijo, H., Molkentin, J.D.
  • 雑誌名: Mol. Cell. Biol. 26 ページ: 3785-3797
• [雑誌論文] Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes. (2006)
  • 著者名/発表者名: Van Laethem, A. et al.
  • 雑誌名: Free Radic. Biol. Med. 41 ページ: 1361-1371
• [雑誌論文] Apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. (2006)
  • 著者名/発表者名: Chiang, E. et al.
  • 雑誌名: J. Immunol. 176 ページ: 5720-5724
• [雑誌論文] Thioredoxin and protein kinases in redox signaling. (2006)
  • 著者名/発表者名: Fujino, G. et al.
  • 雑誌名: Semin. Cancer Biol. 16 ページ: 427-435
• [雑誌論文] Apoptosis Signal-regulating Kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. (2006)
  • 著者名/発表者名: Yokoi, T. et al.
  • 雑誌名: Diabetes 55 ページ: 1660-1665
• [雑誌論文] Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin. Signaling. (2006)
  • 著者名/発表者名: Imoto, K. et al.
  • 雑誌名: Diabetes 55 ページ: 1197-1204
• [雑誌論文] ASK1 Signalosome : a Signaling Complex Essential for Cellular Stress Responses. (2006)
  • 著者名/発表者名: Takeda, K. et al.
  • 雑誌名: J. Oral Biosci. 48 ページ: 7-11
• [雑誌論文] Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. (2006)
  • 著者名/発表者名: Liu, Q.et al.
  • 雑誌名: Mol. Cell. Biol. 26 ページ: 3785-3797
• [雑誌論文] The ASK1-MAP kinase pathways in the immune and stress responses. (2006)
  • 著者名/発表者名: Hayakawa, T. et al.
  • 雑誌名: Microbes Infect. 8 ページ: 1098-1107
• [雑誌論文] The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. (2006)
  • 著者名/発表者名: Sekine, Y. et al.
  • 雑誌名: Curr. Mol. Med. 6 ページ: 87-97
• [雑誌論文] Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide. (2006)
  • 著者名/発表者名: Lee, KH. et al.
  • 雑誌名: Biosci. Biotechnol. Biochem. 70 ページ: 161-171
• [雑誌論文] Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. (2006)
  • 著者名/発表者名: Harada, C. et al.
  • 雑誌名: Am. J. Pathol. 168 ページ: 261-269
• [雑誌論文] Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade. (2006)
  • 著者名/発表者名: Mizumura, K. et al.
  • 雑誌名: J. Cell. Physiol. 206 ページ: 363-370
• [雑誌論文] Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. (2005)
  • 著者名/発表者名: Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., Ichijo, H.
  • 雑誌名: J. Biol. Chem. 280 ページ: 37033-37040
• [雑誌論文] Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death. (2005)
  • 著者名/発表者名: Junn, E., Taniguchi, H., Jeong, B.S., Zhao, X., Ichijo, H., Mouradian, M., M.
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 102 ページ: 9691-9696
• [雑誌論文] ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. (2005)
  • 著者名/発表者名: Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H.
  • 雑誌名: ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. Nature Immunol. 6 ページ: 587-592
• [雑誌論文] ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. (2005)
  • 著者名/発表者名: Matsuzawa, A. et al.
  • 雑誌名: Nat.Immunol. 6 ページ: 587-592
• [雑誌論文] Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. (2005)
  • 著者名/発表者名: Noguchi, T. et al.
  • 雑誌名: J.Biol.Chem. 280 ページ: 37033-37040
• [雑誌論文] Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death. (2005)
  • 著者名/発表者名: Junn, E. et al.
  • 雑誌名: Proc.Natl.Acad.Sci.USA. 102 ページ: 9691-9691
• [雑誌論文] Enhanced TNF-α induced apoptosis in fanconi anemia type C deficient cells is dependent on Apoptosis Signal-regulating Kinase 1. (2005)
  • 著者名/発表者名: Bijangi-Vishehsaraei, K. et al.
  • 雑誌名: Blood 106 ページ: 4124-4130
• [雑誌論文] Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation. (2005)
  • 著者名/発表者名: Kadowaki, H. et al.
  • 雑誌名: Cell Death Differ. 12 ページ: 19-24
• [雑誌論文] Fatty acids liberated from low density lipoprotein trigger endothelial apoptosis via mitogen activated protein kinases. (2005)
  • 著者名/発表者名: Dersch, K. et al.
  • 雑誌名: Cell Death Differ. 12 ページ: 1107-1114
• [雑誌論文] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
  • 著者名/発表者名: Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H., Ichijo, H.
  • 雑誌名: EMBO J. (in press)
• [学会発表] ASK family signaling in stress and disease (2010)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: University of Lausanne Seminar
  • 発表場所: Zurich, Switzerland
  • 年月日: 2010-03-31
• [学会発表] ASK family signaling in stress and disease (2010)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: Emory University Seminar
  • 発表場所: Atlanta, USA
  • 年月日: 2010-03-15
• [学会発表] ASK family signaling in stress and disease (2010)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第15回愛知県がん国際シンポジウム
  • 発表場所: 名古屋
  • 年月日: 2010-03-06
• [学会発表] ASKファミリーによるストレス応答機構と疾患 (2010)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第9回細胞死研究会
  • 発表場所: 京都
• [学会発表] ASKファミリーによるストレス応答機構～浸透圧ストレス応答と血圧制御～ (2009)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第8回 Vascular and Brain Conference
  • 発表場所: 大阪
  • 年月日: 2009-10-09
• [学会発表] ASK-dependent stress signaling in cell death inflammation, and disease (2009)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: pfizer Seminar
  • 発表場所: USA, St.Louis
  • 年月日: 2009-03-23
• [学会発表] Stress Signaling in Cell Death, Inflammation and Disease (2009)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 日米シンポジウム
  • 発表場所: 新潟
• [学会発表] ストレス応答の制御機構〜細胞がストレスを感じる仕組うと疾患〜 (2008)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第6回幹細胞シンポジウム
  • 発表場所: 東京
  • 年月日: 2008-05-27
• [学会発表] ストレスシグナルと発がん(モーニングレクチャー) (2008)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第67回日本癌学会学術総会
  • 発表場所: 名古屋
• [学会発表] 筋萎縮性側索硬化症における小胞体ストレス (2008)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: BMB2008第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • 発表場所: 神戸
• [学会発表] Stress response by the ASK family kinases and their roles in tumorigenesis (2008)
  • 著者名/発表者名: Kohsuke Takeda, et. al.
  • 学会等名: CNU symposium on Microbiology and Molecular Genetics
  • 発表場所: Korea
• [学会発表] Roles of ASK1 in ER stress-induced neurodegeneration (2008)
  • 著者名/発表者名: Hidenori Ichijo
  • 学会等名: 第81回日本薬理学会年会
  • 発表場所: 横浜
• [学会発表] ASKファミリーによるストレスシグナルの制御と疾患 (2007)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第8回循環器薬理セミナー
  • 発表場所: 熊本
  • 年月日: 2007-11-19
• [学会発表] ASK family kinases in stress response and disease (2007)
  • 著者名/発表者名: Hidenori Ichijo
  • 学会等名: The 55th Fall Conference of The Korean Association of Immunobiologists
  • 発表場所: Korea
• [学会発表] ASK family proteins in stress-induced apoptosis and disease (2007)
  • 著者名/発表者名: Hidenori Ichijo
  • 学会等名: FASEB Summer Research Conferences - From unfolded proteins in the endoplasmic reticulum to disease
  • 発表場所: USA
• [学会発表] ASK family proteins in stress response and disease (2007)
  • 著者名/発表者名: Hidenori Ichijo
  • 学会等名: The International Conference on Free Radicals in Biosystems
  • 発表場所: Kuwait
• [学会発表] ASK family proteins in stress-induced apoptosis and disease (2007)
  • 著者名/発表者名: Ichijo, H., et. al.
  • 学会等名: FASEB Summer Research Conferences-From unfolded proteins in the endoplasmic reticulum to disease
  • 発表場所: California, USA.
• [学会発表] がんとストレスシグナル (2007)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第66回日本癌学会学術総会
  • 発表場所: 横浜
• [学会発表] ASKファミリーによるストレス応答の制御 (2007)
  • 著者名/発表者名: 一條秀憲
  • 学会等名: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会(BMB2007)
  • 発表場所: 横浜
• [学会発表] ASK family proteins in stress response and disease (2006)
  • 著者名/発表者名: Hidenori Ichijo
  • 学会等名: 63rd KSBMB Annual Meeting in 2006
  • 発表場所: Korea
  • 年月日: 2006-05-25
• [学会発表] ASK family proteins in stress response and disease (2006)
  • 著者名/発表者名: Hidrnoi Ichijo
  • 学会等名: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • 発表場所: Kyoto
• [学会発表] Redox controls of ASK1-MAP kinase signaling pathway in apoptosis and immunity (2005)
  • 著者名/発表者名: Hidenori Ichijo
  • 発表場所: Italy
  • 年月日: 2005-09-09
• [図書] 創薬科学の魅力-東京大学大学院薬学系研究科からの発信- (2010)
  • 著者名/発表者名: 竹田弘資, 他
  • 出版者: 廣川書店
• [図書] Protein Misfolding Disorders : A Trip into the ER(ed Hetz, C.) (2009)
  • 著者名/発表者名: Nishitoh, H., et al.
  • 出版者: Bentham Science Publishers