小児固形腫瘍の個別化と治療法の開発

• 研究課題/領域番号: 17015046
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 千葉がんセンター
• 研究代表者: 中川原 章 千葉がんセンター, センター長 (50117181)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 66,800千円 (直接経費: 66,800千円); 2009年度: 13,400千円 (直接経費: 13,400千円); 2008年度: 13,400千円 (直接経費: 13,400千円); 2007年度: 13,400千円 (直接経費: 13,400千円); 2006年度: 13,400千円 (直接経費: 13,400千円); 2005年度: 13,200千円 (直接経費: 13,200千円)
• キーワード: 小児がん / 個別化診断 / 個別化治療 / 神経芽腫 / DNAチップ / 個別化医療 / 肝芽腫 / アレイCGH / 実用化DNAチップ

研究概要

小児悪性固形腫瘍、なかでも現在もなお難治性である神経芽腫と肝芽腫を対象とし、網羅的ゲノム解析およびプロテオミクス的手法を用いた新規診断法および臨床リスク分類の作製を行った。具体的には、小児がんに特化して作製した独自のcDNA librariesから11,000個の遺伝子を抽出し、神経芽腫においては、発現プロファイルによる新しい予後予測システムとして診断用実用化ミニチップの作製に成功した。また、BACアレイを基本としたアレイCGH法を用いて、神経芽腫の新しいゲノムリスク分類を確立し、臨床応用へ展開した。さらに、新規血中予後予測マーカーを見いだした。一方、肝芽腫に関しては、アレイCGHに基づく新しいサブタイプ分類が可能となった。このように、手術摘出組織の網羅的な解析から臨床に応用可能な実用的診断および予後予測システムを確立したほか、神経芽腫の発がんに関わる新規KIFIBbeta, RUNX3, ALK遺伝子などを見いだし、これらのうちALKの増幅および点突然変異は臨床的悪性度とも相関していることを明らかにした。

研究成果

• [雑誌論文] MCL-IV, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair. (2010)
  • 著者名/発表者名: Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K.
  • 雑誌名: Biochem. Biophys. Res. Commun. 391 ページ: 492-497
  • 査読あり
• [雑誌論文] LMO3 interacts with p53 and inhibits its transcriptional activity. (2010)
  • 著者名/発表者名: Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A.
  • 雑誌名: Biochem. Biophys. Res. Commun. 392 ページ: 252-257
  • 査読あり
• [雑誌論文] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature. (2010)
  • 著者名/発表者名: De Katleen P, Vermeulen J, Brors B, Delattre O, Eggert A, Fischer M, Janoueix-Lerosey I, Lavarino C, Maris JM, Mora J, Nakagawara A, Oberthuer A, Ohira M, Schleiermacher G, Schramm A, Schulte JH, Wang Q, Westermann F, Speleman F, Vandesompele J.
  • 雑誌名: Clin. Cancer Res. 16 ページ: 1532-1541
  • 査読あり
• [雑誌論文] Bmil is a MYCN target gene and regulates tumorigenesis via repression of KIF1B 13 and TSLC1 in neuroblastoma. (2010)
  • 著者名/発表者名: Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kami jo T.
  • 雑誌名: Oncogene 29 ページ: 2681-2690
  • 査読あり
• [雑誌論文] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p53. (2010)
  • 著者名/発表者名: Yamada C, Ozaki T, Ando K, Suenaga Y, Inoue Kt, Ito Y, Okoshi R, Kageyama H, Kimura H, Miyazaki M, Nakagawara A.
  • 雑誌名: J. Biol. Chem. 285 ページ: 16693-166703
  • 査読あり
• [雑誌論文] MCL-IV, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair. (2010)
  • 著者名/発表者名: Kojima S., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 391 ページ: 492-497
  • 査読あり
• [雑誌論文] LMO3 interacts with p53 and inhibits its transcriptional activity. (2010)
  • 著者名/発表者名: Larsen S., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 392 ページ: 252-257
  • 査読あり
• [雑誌論文] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature. (2010)
  • 著者名/発表者名: De Katleen P., Nakagawara A., et al.
  • 雑誌名: Clin.Cancer Res. 16 ページ: 1532-1541
  • 査読あり
• [雑誌論文] Meta-analysis of neuroblastomas reveals a skewed ALK mutations spectrum in tumors with MYCN amplification. (2010)
  • 著者名/発表者名: De Brouwer S., Nakaeawaza A., et al.
  • 雑誌名: J.Clin.Oncol. (in press)
  • 査読あり
• [雑誌論文] Bmil is a MYCN target gene and regulates tumorigenesis via repression of KIF1Bβ and TSLC1 in neuroblastoma (2010)
  • 著者名/発表者名: Ochiai H., Nakagawara A., et al.
  • 雑誌名: Oncogene (in press)
  • 査読あり
• [雑誌論文] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p53. (2010)
  • 著者名/発表者名: Yamada C., Nakagawara A., et al.
  • 雑誌名: J.Biol.Chem. (in press)
  • 査読あり
• [雑誌論文] Clinicopathological relevance of UbcH10 in breast cancer. (2009)
  • 著者名/発表者名: Fujita T, Ikeda H, Kawasaki K, Taira N, Ogasawara Y, Nakagawara A, Doihara H.
  • 雑誌名: Cancer Sri. 100 ページ: 238-248
  • NAID: 10025142238
  • 査読あり
• [雑誌論文] Distinct role of ShcC docking rotein in the differentiation of neuroblastoma. (2009)
  • 著者名/発表者名: Miyake I, Ohira M, Nakagawara A, Sakai R.
  • 雑誌名: Oncogene 28 ページ: 662-673
  • 査読あり
• [雑誌論文] International consensus for neuroblastoma molecular diagnostics: Report from the international neuroblastoma risk group (INRG) biology committee. (2009)
  • 著者名/発表者名: Ambros PF, Ambros TM, Brodeur GM, Haber M, Khan J, Nakagawara A, Schleiermacher G, Speleman F, Spitz R, London WB, Cohn SL, Pearson ADJ, Maris JM.
  • 雑誌名: Br. J. Cancer 100 ページ: 1471-1482
  • 査読あり
• [雑誌論文] Netrin-1 acts as a survival factor for aggressive neuroblastoma. (2009)
  • 著者名/発表者名: Delloye-Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc-Rasy S, Raquin MA, Stupack D, Nakagawara A, Rousseau R, Combaret V, Puisieux A, Valteau-Couanet D, Benard J, Bernet A, Mehlen P.
  • 雑誌名: J. Exp. Med. 206 ページ: 833-847
  • 査読あり
• [雑誌論文] Plkl regulates liver tumor cell death by phosphorylation of TAp63. (2009)
  • 著者名/発表者名: Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T.
  • 雑誌名: Oncogene 28 ページ: 3631-3641
  • 査読あり
• [雑誌論文] Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73. (2009)
  • 著者名/発表者名: Ozaki T, Okoshi R, Sang M, Kubo N, Nakagawara A.
  • 雑誌名: Biochem. Biophys. Res. Commun. 386 ページ: 207-211
  • 査読あり
• [雑誌論文] Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity. (2009)
  • 著者名/発表者名: Ozaki T, Okoshi R, Ono S, Kubo N, Nakagawara A.
  • 雑誌名: Biochem. Biophys. Res. Commun. 387 ページ: 143-148
  • 査読あり
• [雑誌論文] P1k3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. (2009)
  • 著者名/発表者名: Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, Shimozato O, Geng C, Shan B, Nakagawara A, Ozaki T.
  • 雑誌名: Genes Cells 14 ページ: 775-788
  • 査読あり
• [雑誌論文] A simple PCR method for rapid genotype analysis of the TH柚YCN transgenic mouse. (2009)
  • 著者名/発表者名: Haraguchi S, Nakagawara A.
  • 雑誌名: PLoSONE 4
  • 査読あり
• [雑誌論文] Positive auto-egulation of MYCN in human neuroblastoma. (2009)
  • 著者名/発表者名: Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A.
  • 雑誌名: Biochem. Biophys. Res. Commun. 390 ページ: 21-26
  • 査読あり
• [雑誌論文] Dysregulation of PDGFb-receptor expression by DNp73 in neuroblastoma. (2009)
  • 著者名/発表者名: Wetterskog D, Ozaki T, Nakagawara A, Funa K.
  • 雑誌名: Mol. Cancer Res. 7 ページ: 2031-2039
  • 査読あり
• [雑誌論文] ROS-generating mitochondrial DNA mutation upregulates hypozia-inducible factor-la gene transcription via PI3K-Akt/PKC/HDAC pathway. (2009)
  • 著者名/発表者名: Koshikawa N, Hayashi J-I, Nakagawara A*, Takenaga K*.
  • 雑誌名: J. Biol. Chem. 284 ページ: 33185-33194
  • 査読あり
• [雑誌論文] Transcriptional regulation of tumor suppressor p53 by CREB/AMPK complex in response to glucose deprivation. (2009)
  • 著者名/発表者名: Okoshi R, Ando K, Suenaga Y, Kizaki H, Nakagawara A, Ozaki T.
  • 雑誌名: Genes to Cells. 14 ページ: 1429-1440
  • 査読あり
• [雑誌論文] TBP-like protein (TLP/TRF2/TLF) is engaged in etoposide-induced apoptosis through transcriptional activation of human TAp63 gene. (2009)
  • 著者名/発表者名: Suenaga Y, Ozaki T, Tanaka Y, Bu Y, Kamijo T, Suzuki M, Kimura H, Tokuhisa T, Nakagawara A*, Tamura T*.
  • 雑誌名: J. Biol. Chem. 284 ページ: 35433-35440
  • 査読あり
• [雑誌論文] Clinicopathological relevance of UbcH10 in breast cancer. (2009)
  • 著者名/発表者名: Fujita T, Ikeda H, Kawasaki K, Taira N, Ogasawara Y, Nakagawara A, Doihaza H.
  • 雑誌名: Cancer Sci. 100 ページ: 238-248
  • NAID: 10025142238
  • 査読あり
• [雑誌論文] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1. is associated with poor prognosis in neuroblastoma. (2009)
  • 著者名/発表者名: Yu M., Nakasawara A, et al.
  • 雑誌名: Int.J.Oncol. 34 ページ: 931-938
  • 査読あり
• [雑誌論文] Distinct role of ShcC docking protein in the differentiation of neuroblastoma. (2009)
  • 著者名/発表者名: Miyake I., Nakagawara A., et al.
  • 雑誌名: Onwgene 28 ページ: 662-673
  • 査読あり
• [雑誌論文] Intemational consensus for neuroblastoma molecular diagnostics : Report from the intemational neuroblastoma risk group (INRG) biology committee. (2009)
  • 著者名/発表者名: Ambros PF., Nakasawara A., et al.
  • 雑誌名: Br.J.Cancer 100 ページ: 1471-1482
  • 査読あり
• [雑誌論文] Netrin-1 acts as a survival factor for aggressive neuroblastoma. (2009)
  • 著者名/発表者名: Delloye-Bourgeois C., Nakagawara A., et al.
  • 雑誌名: J.Exp.Med. 206 ページ: 833-847
  • 査読あり
• [雑誌論文] Plkl regulates liver tumor cell death by phosphorylation of TAp63. (2009)
  • 著者名/発表者名: Komatsu S., Nakagawara A., et al.
  • 雑誌名: Oncogene 28 ページ: 3631-3641
  • 査読あり
• [雑誌論文] Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73. (2009)
  • 著者名/発表者名: Ozaki T., Nakaeawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 386 ページ: 207-211
  • 査読あり
• [雑誌論文] Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor (2009)
  • 著者名/発表者名: Ozaki T., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 387 ページ: 143-148
  • 査読あり
• [雑誌論文] P1k3 inhibits pro-apoptotic activity of p73 through physical interaction and phosp horylation. (2009)
  • 著者名/発表者名: Sang M., Nakagawara A., et al.
  • 雑誌名: Genes Cells 14 ページ: 775-788
  • 査読あり
• [雑誌論文] A simle PCR method for rapid genotype analsis of the TH-MYCN transgenic mouse. (2009)
  • 著者名/発表者名: Haraguchi S., Nakagawara A., et al.
  • 雑誌名: PLoSONE 4
  • 査読あり
• [雑誌論文] Positive auto-regulation of MYCN in human neuroblastoma. (2009)
  • 著者名/発表者名: Suenaga Y., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 390 ページ: 21-26
  • 査読あり
• [雑誌論文] Dysregulation of platelet-derived growth factor β-receptor expression by ΔNp73 in neuroblastoma. (2009)
  • 著者名/発表者名: Wetterskog D., Nakagawara A., et al.
  • 雑誌名: Mol.Cancer Res. 7 ページ: 2031-2039
  • 査読あり
• [雑誌論文] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1αgene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. (2009)
  • 著者名/発表者名: Koshikawa N., Nakagawara A^*., et al.
  • 雑誌名: J.Biol.Chem. 284 ページ: 33185-33194
  • 査読あり
• [雑誌論文] Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation. (2009)
  • 著者名/発表者名: Okoshi R., Nakagawara A., et al.
  • 雑誌名: Genes Cells. 14 ページ: 1429-1440
  • 査読あり
• [雑誌論文] TATA-binding protein (TBP)-like protein is engaged in etoposide-induced apoptosis through transcriptional activation of human TAp63 gene. (2009)
  • 著者名/発表者名: Suenaga Y., Nakahawara A^*., et al.
  • 雑誌名: J.Biol.Chem. 284 ページ: 35433-35440
  • 査読あり
• [雑誌論文] Distinct role of ShcC docking protein in the differentiation of neuroblastoma. (2009)
  • 著者名/発表者名: Miyake I., Nakagawara A., et al.
  • 雑誌名: Oncogene 28 ページ: 662-673
  • 査読あり
• [雑誌論文] Netrin-1 acts as a survival factor for aggressive neuroblastoma. (2009)
  • 著者名/発表者名: Delloye-Bourgeois C., Nakagawara A., et al.
  • 雑誌名: J. Exp. Med. 206 ページ: 833-847
  • 査読あり
• [雑誌論文] Report from the international neuroblastoma risk grouping (INRG) biology committee. (2009)
  • 著者名/発表者名: Ambros PF., Nakagawara A., et al.
  • 雑誌名: Br. J. Cancer (in press)
  • 査読あり
• [雑誌論文] TAp63-dependent induction of growth differentiation factor 15 (GDF15) plays a critical role in the regulation of keratinocyte differentiation. (2008)
  • 著者名/発表者名: Ichikawa T, Suenaga Y, Koda T, Ozaki T, Nakagawara A.
  • 雑誌名: Oncogene 27 ページ: 409-420
  • 査読あり
• [雑誌論文] Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature. (2008)
  • 著者名/発表者名: Tomioka N, Oba S, Ohira M, Misra A, Fridly, J, Ishii S, Nakamura Y, Isogai E, Hirata T, Yoshida Y, Todo S, Kaneko Y, Albertson DG, Pinkel D, Feuerstein BG, Nakagawara A.
  • 雑誌名: Oncogene 27 ページ: 441-449
  • 査読あり
• [雑誌論文] ATM-dependent nuclear accumulation of IKK-a plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin. (2008)
  • 著者名/発表者名: Yoshida K, Ozaki T, Furuya K, Nakanishi M, Kikuchi H, Yamamoto H, Ono S, Koda T, Omura K, Nakagawara A.
  • 雑誌名: Oncogene 27 ページ: 1183-1188
  • 査読あり
• [雑誌論文] ERAP140/Nb1a10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid. (2008)
  • 著者名/発表者名: Arai H, Ozaki T, Niizuma H, Nakamura Y, Ohira M, Takano K, Matsumoto M, Nakagawara A.
  • 雑誌名: Oncol. Rep. 19 ページ: 1381-1388
  • 査読あり
• [雑誌論文] Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells. (2008)
  • 著者名/発表者名: Kurata K, Yanagisawa R, Ohira M, Kitagawa M, Nakagawara A, Kamijo T.
  • 雑誌名: Oncogene 27 ページ: 741-754
  • 査読あり
• [雑誌論文] Spl-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway. (2008)
  • 著者名/発表者名: Bu Y, Suenaga Y, Ono S, Koda T, Song F, Nakagawara A, Ozaki T.
  • 雑誌名: Genes to Cells 13 ページ: 53-66
  • 査読あり
• [雑誌論文] Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. (2008)
  • 著者名/発表者名: Okoshi R, Ozaki T, Yamamoto H, Ando K, Koida N, Ono S, Koda T, Kamijo T, Nakagawara A, Kizaki H.
  • 雑誌名: J. Biol. Chem. 283 ページ: 3979-3987
  • 査読あり
• [雑誌論文] A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-ediated apoptotic cell death in its catalytic activity-independent manner. (2008)
  • 著者名/発表者名: Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A.
  • 雑誌名: Oncogene 27 ページ: 3700-3709
  • 査読あり
• [雑誌論文] DNp63/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding. (2008)
  • 著者名/発表者名: Ichikawa T, Suenaga Y, Koda T, Ozaki T, Nakagawara A.
  • 雑誌名: Biochem. Biophys. Res. Commun. 369 ページ: 994-1000
  • 査読あり
• [雑誌論文] The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients. (2008)
  • 著者名/発表者名: Honda S, Haruta M, Sugawara W, Sasaki F, Ohira M, Matsunaga T, Yamaoka H, Horie H, Ohnuma N, Nakagawara A, Hiyama E, Todo S, Kaneko Y.
  • 雑誌名: Int. J. Cancer 123 ページ: 1117-1125
  • 査読あり
• [雑誌論文] A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (2008)
  • 著者名/発表者名: Wang H, Ozaki T, Shamim Hossain M, Nakumura Y, Kamijo T, Xue X, Nakagawara A.
  • 雑誌名: Biochem. Biophys. Res. Commun. 370 ページ: 594-598
  • 査読あり
• [雑誌論文] Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. (2008)
  • 著者名/発表者名: Abe M, Watanabe N, McDonell N, Takato T, Ohira M, Nakagawara A, Ushijima T.
  • 雑誌名: Oncology 74 ページ: 50-60
  • 査読あり
• [雑誌論文] Inhibitory role of Plkl in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. (2008)
  • 著者名/発表者名: Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A.
  • 雑誌名: J. Biol. Chem. 283 ページ: 8555-8563
  • 査読あり
• [雑誌論文] NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage. Biochem. (2008)
  • 著者名/発表者名: Inoue K, Nakanjishi M, Kikuchi H, Yamamoto H, Todo S, Nakagawara A, Ozaki T.
  • 雑誌名: Biophys. Res. Commun. 371 ページ: 829-833
  • 査読あり
• [雑誌論文] Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system. (2008)
  • 著者名/発表者名: Nakagawa H, Ohira M, Hayashi S, Abe S, Saito S, Nagahori N, Monde K, Shinohara Y, Fujitani N, Kondo H, Akiyama S, Nakagawara A, Nishimura S.
  • 雑誌名: Cancer Lett. 270 ページ: 295-301
  • 査読あり
• [雑誌論文] N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. (2008)
  • 著者名/発表者名: Hossain MS, Ozaki T, Wang H, Nakagawa A, Takenobu H, Ohira M, Kamijo T, Nakagawara A.
  • 雑誌名: Oncogene 27 ページ: 6075-6082
  • 査読あり
• [雑誌論文] Expression of TSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation. (2008)
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  • 著者名/発表者名: Isono K, Nakagawara A. et al.
  • 雑誌名: Moll.Cell.Biol 26 ページ: 2758-2771
• [雑誌論文] Decreased expression of pro-apoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with poor prognosis in human neuroblastomas. (2006)
  • 著者名/発表者名: Machida T, Nakagawara A. et al.
  • 雑誌名: Oncogen (in press)
• [雑誌論文] Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma. (2006)
  • 著者名/発表者名: Niizuma H, Nakagawara A. et al.
  • 雑誌名: Oncogen (in press)
• [雑誌論文] Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. (2005)
  • 著者名/発表者名: Kramer S, Ozaki T, Miyazaki K, Kato C, Hanamoto T, Nakagawara A.
  • 雑誌名: Oncogene 24 ページ: 938-944
  • 査読あり
• [雑誌論文] CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. (2005)
  • 著者名/発表者名: Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A, Ushijima T.
  • 雑誌名: Cancer Res. 65 ページ: 828-834
  • 査読あり
• [雑誌論文] A review of DNA microarray analysis of human neurobl ast omas. (2005)
  • 著者名/発表者名: Ohira M, Oba S, Nakamura Y, Hirata T, Ishii S, Nakagawara A.
  • 雑誌名: Cancer Lett. 228 ページ: 5-11
  • 査読あり
• [雑誌論文] Topors, a p53 and topoisomerase I-binding RING finger protein, is a co-activator of p53 in growth suppression induced by DNA damage. (2005)
  • 著者名/発表者名: Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang J-H, Simonds W, Nakagawara A, Koseki H.
  • 雑誌名: Oncogene 24 ページ: 3385-3396
  • 査読あり
• [雑誌論文] Functional implication of p73 protein stability in neuronal cell survival and death. (2005)
  • 著者名/発表者名: Ozaki T, Hosoda M, Miyazaki K, Hayashi S, Watanabe K, Nakagawa T, Nakagawara A.
  • 雑誌名: Cancer Lett. 228 ページ: 29-35
  • 査読あり
• [雑誌論文] Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate risk neuroblastomas. (2005)
  • 著者名/発表者名: Ohira M, Oba S, Nakamura Y, Isogai E, Kaneko S, Nakagawa A, Hirata T, Kubo H, Goto T, Yamada S, Yoshida Y, Fuchioka M, Ishii S, Nakagawara A.
  • 雑誌名: Cancer Cell 7 ページ: 337-350
  • 査読あり
• [雑誌論文] Identification of protein kinase A catalytic subunit b as a novel binding partner of p73 and regulation of p73 function. (2005)
  • 著者名/発表者名: Hanamoto T, Ozaki T, Furuya K, Hosoda M, Hayashi S, Nakanishi M, Yamamoto H, Kikuchi H, Todo S, Nakagawara A.
  • 雑誌名: J. Biol. Chem. 280 ページ: 16665-16675
  • 査読あり
• [雑誌論文] Prediction of MYCN amplification in neuroblastoma using serum DNA and real-time quantitative polymerase chain reaction. (2005)
  • 著者名/発表者名: Gotoh T, Hosoi H, Iehara T, Kuwahara Y, Osone S, Tsuchiya K, Ohira M, Nakagawara A, Kuroda H, Sugimoto T.
  • 雑誌名: J. Clin. Oncol. 23 ページ: 5205-5210
  • 査読あり
• [雑誌論文] Biological role of anaplastic lymphoma kinase in neuroblastoma. (2005)
  • 著者名/発表者名: Osajima-Hakomori Y, Miyake I, Ohira M, Nakagawara A, Nakagawa A, Sakai R.
  • 雑誌名: Am Pathol. 167 ページ: 213-222
  • 査読あり
• [雑誌論文] LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (2005)
  • 著者名/発表者名: Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A.
  • 雑誌名: Cancer Res. 65 ページ: 4587-4597
  • 査読あり
• [雑誌論文] Aberrant methylation of FBN2 in human non-small cell lung cancer. (2005)
  • 著者名/発表者名: Chen H, Suzuki M, Nakamura Y, Ohira M, Ando S, Iida T, NakajimaT, Nakagawara A, Kimura H.
  • 雑誌名: Lung Cancer 50 ページ: 43-49
  • 査読あり
• [雑誌論文] Clinical significance of serum NM23-H1 protein in neuroblastoma. (2005)
  • 著者名/発表者名: Okabe-Kado J, Kasukabe T, Honma Y, Hanada R, Nakagawara A, Kaneko Y.
  • 雑誌名: Cancer Sci. 96 ページ: 653-660
  • NAID: 10017091057
  • 査読あり
• [雑誌論文] p73, a sophisticated p53 family member in the cancer world. (2005)
  • 著者名/発表者名: Ozaki T, Nakagawara A.
  • 雑誌名: Cancer Sci. 96 ページ: 729-737
  • NAID: 10017091352
  • 査読あり
• [雑誌論文] UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiauitination. (2005)
  • 著者名/発表者名: Hosoda M, Ozaki T, Miyazaki K, Hayashi S, Furuya K, Watanabe K, Nakagawa T, Hanamoto T, Todo S, Nakagawara A.
  • 雑誌名: Oncogene 24 ページ: 156-7169
  • 査読あり
• [雑誌論文] Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma. (2005)
  • 著者名/発表者名: Niizuma H, Nakagawara A, 他6名, 8番目
  • 雑誌名: Oncogene 25 ページ: 5046-5055
• [雑誌論文] Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. (2005)
  • 著者名/発表者名: Kramer S, Nakagawara A. et al.
  • 雑誌名: Oncogene 24 ページ: 938-944
• [雑誌論文] CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas (2005)
  • 著者名/発表者名: Abe M, Nakagawara A. et al.
  • 雑誌名: Cancer Res 65 ページ: 828-834
• [雑誌論文] A review of DNA microarray analysis of human neuroblastomas. (2005)
  • 著者名/発表者名: Ohira M, Nakagawara A. et al.
  • 雑誌名: Cancer Lett 228 ページ: 5-11
• [雑誌論文] Topors, a p53 and topoisomerase I-binding RING finger protein, is a co-activator of p53 in growth suppression induced by DNA damage. (2005)
  • 著者名/発表者名: Lin L, Nakagawara A. et al.
  • 雑誌名: Oncogen 24 ページ: 3385-3396
• [雑誌論文] Functional implication of p73 protein stability in neuronal cell survival and death (2005)
  • 著者名/発表者名: Ozaki T, Nakagawara A. et al.
  • 雑誌名: Cancer Lett 228 ページ: 29-35
• [雑誌論文] (2005)
  • 著者名/発表者名: Ohira M, Nakagawara A. et al.
  • 雑誌名: Cancer Cell 7 ページ: 337-350
• [雑誌論文] UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination. (2005)
  • 著者名/発表者名: Hosoda M, Nakagawara A. et al.
  • 雑誌名: Oncogen 24 ページ: 7156-7169
• [雑誌論文] Identification of protein kinase A catalytic subunit beta as a novel binding partner of p73 and regulation of p73 function. (2005)
  • 著者名/発表者名: Hanamoto T, Nakagawara A., et al.
  • 雑誌名: J.Biol.Chem. 280 ページ: 16665-16675
• [雑誌論文] Sugimoto T. Prediction of MYCN amplification in neuroblastoma using serum DNA and real-time quantitative PCR. (2005)
  • 著者名/発表者名: Gotoh T, Nakagawara A. et al.
  • 雑誌名: J.Clin.Oncol 23 ページ: 5205-5210
• [雑誌論文] Biological role of anaplastic lymphoma kinase in neuroblastoma. (2005)
  • 著者名/発表者名: Osajima-Hakomori Y, Nakagawara A. et al.
  • 雑誌名: Am J Pathol 167 ページ: 213-222
• [雑誌論文] LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (2005)
  • 著者名/発表者名: Aoyama M, Nakagawara A. et al.
  • 雑誌名: Cancer Res 167 ページ: 4587-4597
• [雑誌論文] Clinical significance of serum NM23-H1 protein in neuroblastoma. (2005)
  • 著者名/発表者名: Okabe-Kado J, Nakagawara A. et al.
  • 雑誌名: Cancer Sci 96 ページ: 653-660
  • NAID: 10017091057
• [雑誌論文] p73, a sophisticated p53 family member in the cancer world. (2005)
  • 著者名/発表者名: Ozaki T, Nakagawara A. et al.
  • 雑誌名: Cancer Sci. 96 ページ: 729-737
  • NAID: 10017091352
• [雑誌論文] Meta-analysis of neuroblastomas reveals a skewed ALK mutations spectrum in tumors with MYCN amplification.
  • 著者名/発表者名: De Brouwer S, De Preter K, Kumps C, Westerhout E, Lakeman A, Hoebeeck J, Van Maerken T, Laureys G, Schulte JH, Noguera R, Delattre O, Janouiex-Lerosey I, Kogner P, Martinsson T, Nakagawara A, Ohira M, Caron H, Eggert A, Versteeg R, Speleman F.
  • 雑誌名: J. Glin. Oncol. (Accepted)
  • 査読あり
• [雑誌論文] DFF45/ICAD restores cisplatin-induced nuclear fragmentation but not DNA cleavage in DFF45-deficient neuroblastoma cells.
  • 著者名/発表者名: Takahashi M, Nakagawara A, 他8名, 10番目
  • 雑誌名: Oncogene (In Press)
• [雑誌論文] Stabilization of p73 by nuclear IKK-a mediates cisplatin-induced apoptosis.
  • 著者名/発表者名: Furuya K, Nakagawara A, 他7名, 9番目
  • 雑誌名: J. Biol. Chem. (In press)
• [学会発表] Role of dependence receptors in spontaneous regression of neuroblastoma. (2007)
  • 著者名/発表者名: Nakagawara A.
  • 学会等名: 第66回日本癌学会学術総会
  • 発表場所: 横浜
  • 年月日: 2007-10-03
• [図書] Neuroblastoma(Eds. N-K. Cheung & S. Cohn, Molecular and developmental biology of neuroblastoma., Chapter 5.) (2005)
  • 著者名/発表者名: Nakagawara A.
  • 出版者: Springer-Verlag
• [図書] Neuroblastoma (2005)
  • 著者名/発表者名: Nakagawara A.
  • 総ページ数: 13
  • 出版者: Springer-Verlag, Heidelberg