がん転移浸潤の糖鎖バイオロジー

• 研究課題/領域番号: 17015051
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 愛知県がんセンター(研究所)
• 研究代表者: 神奈木 玲児 愛知県がんセンター(研究所), 分子病態学部, 部長 (80161389)
• 研究分担者: 卓 麗聖 愛知医科大学, 医学部, 准教授 (00399031) ; 田口 修 愛知県がんセンター(研究所), 分子病態学部, 室長 (00142167) ; 後藤 嘉子 愛知県がんセンター(研究所), 分子病態学部, 技師 (30416169)
• 連携研究者: 田口 修 愛知県がんセンター(研究所), 分子病態学部, 室長 (00142167) ; 遊佐 亜希子 愛知県がんセンター(研究所), 分子病態学部, リサーチレジデント (00455536)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 64,000千円 (直接経費: 64,000千円); 2009年度: 12,000千円 (直接経費: 12,000千円); 2008年度: 12,000千円 (直接経費: 12,000千円); 2007年度: 13,400千円 (直接経費: 13,400千円); 2006年度: 13,400千円 (直接経費: 13,400千円); 2005年度: 13,200千円 (直接経費: 13,200千円)
• キーワード: セレクチン / CD44 / ヒアルロン酸 / エピジェネティック・サイレンシング / hypoxia induciblefactor(HIF) / シアリルルイスX / シアリルルイスa / 細胞接着分子 / hypoxia inducible factor (HIF) / 成人T細胞性白血病 / 硫酸化シアリルルイスX / Th2細胞 / 皮膚ホーミング / 6-硫酸基転移酵素 / GATA-3 / NF-κB / CD22 / 糖鎖リガンド / ナイーブB細胞 / Siglec-2 / Epratuzumab / Inotuzumab / リンパ性白血病 / 悪性リンパ腫 / 細胞接着 / 血行性転移 / 転写調節 / MZF-1 / T-bet / HIF-1 / リンパ節浸潤 / ホーミング / シアリル6-スルホルイスX / 白血病

研究概要

細胞表層の糖鎖には接着分子としての機能を持つものがある。癌細胞ではシアリルルイスXやシアリルルイスaなどの糖鎖が発現し、これによって転移や浸潤が引き起こされる。癌細胞で糖鎖が変化する機構は、発癌早期においては、正常型糖鎖を合成する一連の遺伝子のエピジェネティック・サイレンシングが主原因の一つとなっていることを我々は明らかにした。一方、進行期の癌においては、癌細胞の低酸素抵抗性の獲得とともに機能亢進する転写因子hypoxia inducible factor(HIF)が、一連の糖鎖合成遺伝子の転写を誘導することが大きな要因となっていることを我々は明らかにした。

研究成果

• [雑誌論文] Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia: Clues in the ongoing search for new tumor markers. (2010)
  • 著者名/発表者名: Kannagi, R., Sakuma, K., Miyazaki, K., Lim, K-T., Yusa, A., Yin, J., Izawa, M.
  • 雑誌名: Cancer Sci. CancerSci. ページ: 586-593
  • NAID: 10026588975
• [雑誌論文] Rap1 controls lymphocyte adhesion cascades and interstitial migration within lymph nodes in a RAPL-dependent and independent manner. (2010)
  • 著者名/発表者名: Ebisuno, T., Katagiri, K., Katakai, T., Ueda, Y., Nemoto, T., Inada, H., Nabekura, J., Okada, T., Kannagi, R., Tanaka, T., Miyasaka, M., Hogg, N., Kinashi, T.
  • 雑誌名: Blood 115 ページ: 804-814
• [雑誌論文] Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia : Clues in the ongoing seazch for new tumor mazkers. (2010)
  • 著者名/発表者名: Kannagi, R., et al.
  • 雑誌名: Cancer Sci. 101 ページ: 586-593
  • 査読あり
• [雑誌論文] Rap1 controls lymphocyte adhesion cascades and interstitial migration within lymph nodes in a RAPL-dependent and independent manner. (2010)
  • 著者名/発表者名: Ebisuno, T., et al.
  • 雑誌名: Blood 115 ページ: 804-814
  • 査読あり
• [雑誌論文] Inter-α-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. (2009)
  • 著者名/発表者名: Adair, J.E., Stober, V., Sobhany, M., Zhuo, L., Roberts, J.D., Negishi, M., Kimata, K., Garantziotis, S.
  • 雑誌名: J. Biol. Chem. 284 ページ: 16922-16930
• [雑誌論文] Expression of sialyl Lex, sialyl Lea, Lex and Ley glycotopes in secreted human ovarian cyst glycoproteins. (2009)
  • 著者名/発表者名: Yang, Z., Wu, J.H., Kuo, H.W., Kannagi, R., Wu, A.M.
  • 雑誌名: Biochimie 91 ページ: 423-433
• [雑誌論文] Expression of sialyl Lex, sialyl Lea, Lex and Ley glycotopes in secreted human ovariancyst glycoproteins (2009)
  • 著者名/発表者名: Yang, Z., et al.
  • 雑誌名: Biochimie 91 ページ: 423-433
  • 査読あり
• [雑誌論文] Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. (2009)
  • 著者名/発表者名: Adair, J.E., et al.
  • 雑誌名: J.Biol.Chem. 284 ページ: 16922-16930
  • 査読あり
• [雑誌論文] Significance of NF-κB/GATA axis in TNF-α-induced expression of 6-sulfated cell-recognition glycans in human T-lymphocytes. (2008)
  • 著者名/発表者名: Chen, G. -Y., Sakuma, K., Kannagi, R.
  • 雑誌名: J. Biol. Chem. 283 ページ: 34563-34570
• [雑誌論文] Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants- Biochim. (2008)
  • 著者名/発表者名: Kannagi, R., Yin, J., Miyazaki, K., Izawa, M.
  • 雑誌名: Biophys. Acta 1780 ページ: 525-531
• [雑誌論文] DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. (2008)
  • 著者名/発表者名: Kawamura, Y.I., Toyota, M., Kawashima, R., Hagiwara, T., Suzuki, H., Imai, K., Shinomura, Y., Tokino, T., Kannagi, R., Dohi, T.
  • 雑誌名: Gastroenterology 135 ページ: 142-151
• [雑誌論文] CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1. (2008)
  • 著者名/発表者名: Nonomura, C., Kikuchi, J., Kiyokawa, N., Ozaki, H., Mitsunaga, K., Ando, H., Kanamori, A., Kannagi, R., Fujimoto, J., Muroi, K., Furukawa, Y., Nakamura, M.
  • 雑誌名: Cancer Res. 68 ページ: 790-799
• [雑誌論文] Clinical application of functional glycoproteomics - dissection of glycotopes carried by soluble CD44 variants in sera of patients with cancers. (2008)
  • 著者名/発表者名: Lim, K-T., Miyazaki, K., Kimura, N., Izawa, M., Kannagi, R.
  • 雑誌名: Proteomics 8 ページ: 3263-3273
• [雑誌論文] Significance of NF-kappaB/GATA axis in TNF-alpha -induced expression of 6-sulfated cell-recognition glycans in human T-lymphocytes (2008)
  • 著者名/発表者名: Chen, G.・Y. et al.
  • 雑誌名: J. Biol. Chem. 283 ページ: 34563-34570
  • 査読あり
• [雑誌論文] DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer (2008)
  • 著者名/発表者名: Kawamura, Y.I. et al.
  • 雑誌名: Gastroenterology 135 ページ: 142-151
  • 査読あり
• [雑誌論文] CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-Is (2008)
  • 著者名/発表者名: Nonomura, C. et al.
  • 雑誌名: Cancer Res. 68 ページ: 790-799
  • 査読あり
• [雑誌論文] Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants (2008)
  • 著者名/発表者名: Kannagi, R. et al.
  • 雑誌名: Biochim. Biophys. Acta 1780 ページ: 525-531
  • 査読あり
• [雑誌論文] Human B-lymphocytes expressα2-6 sialylated 6-sulfo-N-acetyllactosamine serving as a preferred ligand for CD22/siglec-2. (2007)
  • 著者名/発表者名: Kimura, N., Ohmori, K., Miyazaki, K., Izawa, M., Matsuzaki, Y., Yasuda, Y., Takematsu, H., Kozutsumi, Y., Moriyama, A., Kannagi, R.
  • 雑誌名: J. Biol. Chem. 282 ページ: 32200-32207
• [雑誌論文] Hyperproduction of hyaluronan in Neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: Possible involvement of versican/PG-M. (2007)
  • 著者名/発表者名: Koyama, H., Hibi, T., Isogai, Z., Yoneda, M., Fujimori, M., Amano, J., Kawakubo, M., Kannagi, R., Kimata, K., Taniguchi, S., Itano, N.
  • 雑誌名: Am. J. Pathol. 170 ページ: 1086-1099
• [雑誌論文] Successful tumor eradication was achieved by collaboration of augmented cytotoxic activity and anti-angiogenic effects following therapeutic vaccines containing helper-activating analog-loaded dendritic cells and tumor antigen DNA. (2007)
  • 著者名/発表者名: Teramoto, K., Kontani, K., Fujita, T., Ozaki, Y., Sawai, S., Tezuka, N., Fujino, S., Itoh, Y., Taguchi, O., Kannagi, R., Ogasawara, K.
  • 雑誌名: Cancer Immunol. Immunother. 56 ページ: 331-342
• [雑誌論文] Glycomic mapping of pseudomucinous human ovarian cyst glycoproteins: Identification of Lewis and sialyl Lewis glycotopes. (2007)
  • 著者名/発表者名: Wu, A.M., Khoo, K.H., Yu, S.Y., Yang, Z., Kannagi, R., Watkins, W.M.
  • 雑誌名: Proteomics 7 ページ: 3699-3717
• [雑誌論文] Human B-lymphocytes express α 2-6 sialylated 6-sulfo-N-acetyllactosamineserving as a preferred ligand for CD22/siglec-2 (2007)
  • 著者名/発表者名: Kimura, N., et. al.
  • 雑誌名: J.Biol.Chem. 282 ページ: 32200-32207
  • 査読あり
• [雑誌論文] Glycomic mapping of pseudomucinous human ovarian cyst glycoproteins:Identification of Lewis and sialyl Lewis glycotoues (2007)
  • 著者名/発表者名: Wu, AM., et. al.
  • 雑誌名: Prooteomics 7 ページ: 3699-3717
  • 査読あり
• [雑誌論文] Successful tumor eradication was achieved by collaboration of augmented cytotoxic activity and anti-aniogenic effects following therapeutic vaccines containing helper-activating analog-Ioaded dendritic cells and tumor antigen DNA (2007)
  • 著者名/発表者名: Teramoto, K., et. al.
  • 雑誌名: Cancer Immunol. Immuother. 56 ページ: 331-342
  • 査読あり
• [雑誌論文] Hyperproduction of hyaluronan in Neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: Possible invovement of versican/PG-M (2007)
  • 著者名/発表者名: Koyama, H., et. al.
  • 雑誌名: Am.J.Pathol. 170 ページ: 1086-1099
  • 査読あり
• [雑誌論文] Chapter 22, Silectin-mediated metastasis of tumor cells:Alteration of carbohydrate-mediated cell-cell interactions in cancers induced by epigenetic silencing of glycogenes (2007)
  • 著者名/発表者名: Kannagi, R., et. al.
  • 雑誌名: Glycobiology (eds. Sansom, C, ; Markman, O.), Scion Publishing Ltd., Bloxham,Oxfordshire, UK. ページ: 274-287
• [雑誌論文] nteraction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. (2006)
  • 著者名/発表者名: Chen, G. -Y., Osada, H., Santamaria- Babi, L.F., Kannagi, R.
  • 雑誌名: Proc. Natl. Acad. Sci. U.S.A. 103 ページ: 16894-16899
• [雑誌論文] Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter (2006)
  • 著者名/発表者名: Kamiyama, S., Sasaki, N., Goda, E., Ui-Tei, K., Saigo, K., Narimatsu, H., Jigami, Y., Kannagi, R., Irimura, T., Nishihara, S.
  • 雑誌名: PAPST2. J. Biol. Chem. 281 ページ: 10945-10953
• [雑誌論文] Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS. (2006)
  • 著者名/発表者名: Kyogashima, M., Tamiya-Koizumi, K., Ehara, T., Li, G., Hu, R., Hara, A., Aoyama, T., Kannagi, R.
  • 雑誌名: Glycobiology 16 ページ: 719-728
• [雑誌論文] Identification of cutaneous lymphocyte- associated antigen as sialyl 6-sulfo Lewis x, a selectin ligand expressed on a subset of skin-homing helper memory T cells. (2006)
  • 著者名/発表者名: Ohmori, K., Fukui, F., Kiso, M., Imai, T., Yoshie, O., Hasegawa, H., Matsushima, K., Kannagi, R.
  • 雑誌名: Blood 107 ページ: 3197-3204
• [雑誌論文] Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. (2006)
  • 著者名/発表者名: Yin, J., Hashimoto, A., Izawa, M., Miyazaki, K., Chen, G. -Y., Takematsu, H., Kozutsumi, Y., Suzuki, A., Furuhata, K., Cheng, F. -L., Lin, C. -H., Sato, C., Kitajima, K., Kannagi, R.
  • 雑誌名: Cancer Res. 66 ページ: 2937-2945
• [雑誌論文] SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. (2006)
  • 著者名/発表者名: Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K.
  • 雑誌名: J. Biol. Chem. 281 ページ: 20303-20314
• [雑誌論文] GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. (2006)
  • 著者名/発表者名: Chen, G.-Y., Osada, H., Santamaria-Babi, L.F., Kannagi, R.
  • 雑誌名: Proc. Natl. Acad. Sci. U. S. A. 103 ページ: 16894-16899
• [雑誌論文] Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. (2006)
  • 著者名/発表者名: Yin, J., Hashimoto, A., Izawa, M., Miyazaki, K., et al.
  • 雑誌名: Cancer Res. 66 ページ: 2937-2945
• [雑誌論文] Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis x, a selectin ligand expressed on a subset of skin-homing helper memory T cells. (2006)
  • 著者名/発表者名: Ohmori, K., Fukui, F., Kiso, M., Imai, T., Yoshie, O., Hasegawa, H., Matsushima, K., Kannagi, R.
  • 雑誌名: Blood 107 ページ: 3197-3204
• [雑誌論文] SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. (2006)
  • 著者名/発表者名: Zhuo, L., et al.
  • 雑誌名: J. Biol. Chem. 281 ページ: 20303-20314
• [雑誌論文] Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2. (2006)
  • 著者名/発表者名: Kamiyama, S., et al.
  • 雑誌名: J. Biol. Chem. 281 ページ: 10945-10953
• [雑誌論文] Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis x, a selectin ligand expressed on a subset of skin-homing helper memory T cells (2006)
  • 著者名/発表者名: Ohmori, K., Fukui, F., et al.
  • 雑誌名: Blood 107(in press)
• [雑誌論文] Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2 (2006)
  • 著者名/発表者名: Kamiyama, S., et al.
  • 雑誌名: J.Biol.Chem. 281(in press)
• [雑誌論文] Synthesis of {α}(1, 3)fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. (2005)
  • 著者名/発表者名: Satoh, T., Kanai, Y., Wu, M.H., Yokozeki, H., Kannagi, R., Lowe, J.B., Nishioka, K.
  • 雑誌名: Am. J. Pathol. 167 ページ: 787-796
• [雑誌論文] A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules. (2005)
  • 著者名/発表者名: Uchimura, K., Gauguet, J.M., Singer, M.S., Tsay, D., Kannagi, R., Muramatsu, T., Von Andrian, U.H., Rosen, S.D.
  • 雑誌名: Nat. Immunol. 6 ページ: 1105-1113
• [雑誌論文] Development of structural analysis of sulfated N- glycans by multi-dimensional HPLC mapping methods. (2005)
  • 著者名/発表者名: Yagi, H., Takahashi, N., Yamaguchi, Y., Kimura, N., Uchimura, K., Kannagi, R., Kato, K.
  • 雑誌名: Glycobiology 15 ページ: 1051-1060
• [雑誌論文] Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells (2005)
  • 著者名/発表者名: Yin, J., Hashimoto, A., et al.
  • 雑誌名: Cancer Res. 66 ページ: 2937-2945
• [雑誌論文] A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules (2005)
  • 著者名/発表者名: Uchimura, K., et al.
  • 雑誌名: Nat.Immun. 6 ページ: 1105-1113
• [雑誌論文] Synthesis of α(1,3)fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin (2005)
  • 著者名/発表者名: Satoh, T., Kanai, Y., et al.
  • 雑誌名: Am.J.Pathol. 167 ページ: 787-796
• [雑誌論文] Development of structural analysis of sulfated N-glycans by multi-dimensional HPLC mapping methods (2005)
  • 著者名/発表者名: Yagi, H., Takahashi, N., et al.
  • 雑誌名: Glycobiology 15 ページ: 1051-1060
• [学会発表] Roles of epigenetic gene silencing and tumor hypoxia in induction of cancer-associated carbohydrate determinants (2009)
  • 著者名/発表者名: Kannagi R
  • 学会等名: 2nd Seminar on Functional Glycomics, "Clinical and translational research on cancer: Glycomics application", (Chaired by Paulson J and Taniguchi N)
  • 発表場所: Toba, Japan
• [学会発表] Carbohydrate- mediated cell adhesion involved in pathogenic homing behaviors of Tand B-lymphocytes. (2009)
  • 著者名/発表者名: Kannagi R, Sakuma K, Miyazaki K, Kimura N, Ohmori K
  • 学会等名: 20th International Symposium on Glycoconjugates
  • 発表場所: San Juan, Puerto Rico
• [学会発表] Cazbohydrate-mediated cell adhesion involved in pathogenic homing behaviors of T- and B-lymphocytes (2009)
  • 著者名/発表者名: Kannagi, R.
  • 学会等名: GLYCO XX (20th International Symposium on Glycoconjugates)
  • 発表場所: San Juan, Puerto Rico
• [学会発表] Regulation of glycosyltransferase gene expression involved in lymphocyte homing (2008)
  • 著者名/発表者名: Kannagi, R.
  • 学会等名: Sixth International Glycosyltransferase Conference
  • 発表場所: Atlanta, GA, USA,
  • 年月日: 2008-05-20
• [学会発表] Immunogenic GM2 ganglioside antigen on cancer cells (2008)
  • 著者名/発表者名: Kannagi R
  • 学会等名: Gordon Research Conference 2008
  • 発表場所: Lucca, Italy
  • 年月日: 2008-02-18
• [学会発表] Immunogenic GM2 ganglioside antigen on cancer cells (2008)
  • 著者名/発表者名: Kannagi R
  • 学会等名: Gordon Research Conferences 2008 "Glycolipid & Sphingolipid Biology", (Chaired by Gerrit Van Meer)
  • 発表場所: Lucca Italy
• [学会発表] Regulation of glycosyltransferase gene expression involved in lymphocyte homing (2008)
  • 著者名/発表者名: Chen G-Y, Sakuma K, Kannagi R
  • 学会等名: Sixth International Glycosyltransferase Conference (GlycoT2008), (Chaired by R. Cummings and M. Pierce)
  • 発表場所: Atlanta, USA
• [学会発表] Sialylated and sulfated ligands on human B-lymphocytes for CD22/Siglec2 (2008)
  • 著者名/発表者名: Kannagi R, Ohmori K, Sakuma K, Kimura N
  • 学会等名: 12th International Conference on Biology and Chemistry of Sialic Acid (SialoGlycoT2008), (Chaired by N. V Bovin)
  • 発表場所: Moscow-St. Petersburg, Russia
• [学会発表] Selectin-mediated cell adhesion in cancer metastasis (2007)
  • 著者名/発表者名: Kannagi R
  • 学会等名: 19th FAOBMB Conference, Symposium "Cell adhesion and migration"
  • 発表場所: Seoul,Korea
  • 年月日: 2007-05-30
• [学会発表] Selectin-mediated cell adhesion in cancer metastasis. (2007)
  • 著者名/発表者名: Kannagi R
  • 学会等名: 19th FAOBMB Conference, Symposium "Cell adhesion and migration" (Chaired by WK Song and JW Lee)
  • 発表場所: Seoul
• [学会発表] Hypoxia-induced expression of cancer-associated glycoconjugates (2007)
  • 著者名/発表者名: Kannagi R
  • 学会等名: The 27th Sapporo Cancer Seminar International Symposium "Glycomics: new perspectives in cancer cell behavior", (Chaired by N Taniguchi)
  • 発表場所: Sapporo
• [学会発表] Tumor hypoxia induces expression of carbohydrate determinants involved in adhesion of circulating cancer cells to vascular endothelium. (2006)
  • 著者名/発表者名: Kannagi R
  • 学会等名: The 11th International Congress of the Metastasis Research Society
  • 発表場所: Tokushima
• [学会発表] Transcriptional regulation of ficosyltransferase VII, a rate-limiting enzyme for selectin ligand synthesis (2005)
  • 著者名/発表者名: Kannagi R
  • 学会等名: 2nd Workshop the Netherlands- Japan on Recent Advances in Glycobiology, Chaired by H.
  • 発表場所: Vliegenthart, Utrecht, The Netherland
• [図書] Essentials of Glycobiology (2009)
  • 著者名/発表者名: Varki, A., Kannagi, R., Toole, B.P. Glycosylation changes in cancer. In: A. Varki, R.D. Cummings, J.D. Esko, H.H. Freeze, G.W. Hart, J.D. Marth
  • 出版者: Cold Spring Harbor Laboratory Press
• [図書] Essentials of Glycobiology ; Chapter 44, Glycosylation changes in cancer. (2009)
  • 著者名/発表者名: Varki, A., et al.
  • 総ページ数: 16
  • 出版者: Cold Spring Harbor Laboratory Press
• [図書] Roles of carbohydrate-mediated cell adhesion in cancer progression. In: N. Taniguchi, A. Suzuki, Y. Ito, H. et al. (eds. ) (2008)
  • 著者名/発表者名: Kannagi, R., Seko, A.
  • 出版者: Springer Japan
• [図書] Experimental Glycoscience, Glycobiology (2008)
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• [図書] Alteration of carbohydrate- mediated cell-cell interactions in cancers induced by epigenetic silencing of glycogenes. In: C. Sansom and O. Markman (eds. ) (2007)
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  • 出版者: Scion Publishing Ltd., Bloxham, Oxfordshire, UK.
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  • URL: http://www.pref.aichi.jp/cancer-center/400/420/421/421-07.html
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  • URL: http://www.pref.aichi.jp/cancer-center/english/s-report/06_07/07mp.html
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  • URL: http://www.pref.aichi.jp/cancer-center/400/420/421/421-07.html
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  • URL: http://www.pref.aichi.jp/cancer-center/english/s-report/06_07/07mp.html
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  • URL: http://www.pref.aichi.jp/cancer-center/400/420/421/421-07.html