抗体療法の科学的臨床研究

• 研究課題/領域番号: 17016065
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 17016065
• 研究代表者: 上田 龍三 17016065, 大学院・医学研究科, 教授 (20142169)
• 研究分担者: 佐藤 滋樹 名古屋市立大学, 大学院・医学研究科, 准教授 (80254283) ; 小松 弘和 名古屋市立大学, 大学院・医学研究科, 准教授 (60336675) ; 石田 高司 (石出 高司) 名古屋市立大学, 大学院・医学研究科, 講師 (80405183) ; 吉川 和宏 愛知医科大学, 医学部, 講師 (60109759) ; 飯田 真介 名古屋市立大学, 大学院・医学研究科, 准教授 (50295614)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 209,100千円 (直接経費: 209,100千円); 2009年度: 41,800千円 (直接経費: 41,800千円); 2008年度: 41,800千円 (直接経費: 41,800千円); 2007年度: 41,800千円 (直接経費: 41,800千円); 2006年度: 41,800千円 (直接経費: 41,800千円); 2005年度: 41,900千円 (直接経費: 41,900千円)
• キーワード: 抗体療法 / CCR4 / ADCC / 成人T細胞白血病リンパ腫(ATL) / ケモカイン / CD10 / 抗体リモデリング / CCD4

研究概要

ケモカインレセプターCCR4が難治性T細胞性リンパ腫に特異的に発現していることを見出し、CCR4に対する低フコース型治療抗体の抗腫瘍効果をin vitro及びin vivoで示した。の開発研究を行った。さらに、これらの前臨床研究を基盤とし、CCR4陽性末梢性T 細胞性リンパ腫患者を対象としたフコース除去ヒト化抗CCR4抗体 (KW-0761)の第I相及び第II 相臨床試験を欧米諸国に先駆け日本で実施、本薬剤の承認申請のための臨床データを得た。

研究成果

• [雑誌論文] Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma (ATLL). (2010)
  • 著者名/発表者名: Ishii T, Ishida T, Utsunomiya A, Inagaki A, Yano H, Komatsu H, Iida S, Imada K, Uchiyama T, Akinaga S, Shitara K, Ueda R
  • 雑誌名: Clin Cancer Res. 16 ページ: 1520-1531
  • 査読あり
• [雑誌論文] Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients with Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma. (2010)
  • 著者名/発表者名: Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y. Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
  • 雑誌名: J Clin Oncol. 28 ページ: 1591-8
  • 査読あり
• [雑誌論文] Phase I study of KW-0761, a defucosylated anit-CCR4 antibody, in relapsed patients with adult T-cell leukemia lymphoma and peripheral T-cell lymphoma (2010)
  • 著者名/発表者名: Yamamoto K
  • 雑誌名: J Clin Oncol. 28(9) ページ: 1591-1598
  • 査読あり
• [雑誌論文] Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma (ATLL). (2010)
  • 著者名/発表者名: Ishii T
  • 雑誌名: Clin Cancer Res. 16 ページ: 1520-1531
  • 査読あり
• [雑誌論文] がん研究にかかわる特定領域研究(主な研究成果)(平成16年度-21年度) (2010)
  • 著者名/発表者名: がん特、広報・企画支援委員会
  • 雑誌名: 報告集(パンフレット) ページ: 1-33
• [雑誌論文] Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL Cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2Rgamma(null) mice in vivo. (2009)
  • 著者名/発表者名: Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
  • 雑誌名: J Immunol. 183 ページ: 4782-91
  • 査読あり
• [雑誌論文] The Asn505 mutation of c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity. (2009)
  • 著者名/発表者名: Ding J, Komatsu H, Iida S, Yano H, Kusumoto S, Inagaki A, Mori F, Ri M, Ito A, Wakita A, Ishida T, Nitta M, Ueda R
  • 雑誌名: Blood 114 ページ: 3325-8
  • 査読あり
• [雑誌論文] Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC. (2009)
  • 著者名/発表者名: Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, Ri M, Mori F, Ding J, Komatsu H, Iida S, Ueda R
  • 雑誌名: Int J Cancer 125 ページ: 212-21
  • 査読あり
• [雑誌論文] Bortezomib-induced apoptosis in mature T-cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl-1. (2009)
  • 著者名/発表者名: Ri M, Iida S, Ishida T, Ito A, Yano H, Inagaki A, Ding J, Kusumoto S, Komatsu H, Utsunomiya A, Ueda R
  • 雑誌名: Cancer Sci. 100 ページ: 341-8
  • NAID: 10025142727
  • 査読あり
• [雑誌論文] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. (2009)
  • 著者名/発表者名: Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
  • 雑誌名: Cancer Immunol Immunother 58 ページ: 1195-206
  • 査読あり
• [雑誌論文] The Asn505 mutation of c-MPL gene, which causes familial essential thrombocyt hernia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity. (2009)
  • 著者名/発表者名: Ding J
  • 雑誌名: Blood 114 ページ: 3325-3328
  • 査読あり
• [雑誌論文] Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against prima ry ATLL cells mediated by autologous human immune cells inNOD/Shi-scid,, IL-2R qamma (null) mice in vivo. (2009)
  • 著者名/発表者名: Ito A
  • 雑誌名: J Immunol 183(7) ページ: 4782-4791
  • 査読あり
• [雑誌論文] Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma. (2008)
  • 著者名/発表者名: Yano H, Kayukawa S, Iida S, Nakagawa C, Oguri T, Sanda T, Ding J, Mori F, Ito A, Ri M, Inagaki A, Kusumoto S, Ishida T, Komatsu H, Inagaki H, Suzuki A, Ueda R
  • 雑誌名: Cancer Sci. 99 ページ: 2309-14
  • NAID: 10024013572
  • 査読あり
• [雑誌論文] Augmentation of antitumour activity of defucosylated chimeric anti-CCR4 monoclonal antibody in SCID mouse model of adult T-cell leukaemia/lymphoma using G-CSF. (2008)
  • 著者名/発表者名: Yano H, Ishida T, Imada K, Sakai T, Ishii T, Inagaki A, Iida S, Uchiyama T, Ueda R
  • 雑誌名: Br J Haematol 140 ページ: 586-9
  • 査読あり
• [雑誌論文] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients (2008)
  • 著者名/発表者名: Yamaguchi, M
  • 雑誌名: Haematologica 93(8) ページ: 1195-202
  • 査読あり
• [雑誌論文] Combinations of tumor-specific CD8+ CTLs and anti-CD25 mAbprovide improved immunotherapy (2008)
  • 著者名/発表者名: Ohmura Y
  • 雑誌名: Oncol Rep 19(5) ページ: 1265-70
  • 査読あり
• [雑誌論文] Induction of class II major histocompatibility complex expression in human multiple myeloma cellsby retinoid (2008)
  • 著者名/発表者名: Sanda, T.
  • 雑誌名: Haematologica 92(1) ページ: 115-20
  • 査読あり
• [雑誌論文] Regulatory T-cell function of adult T-cell leukemia/lymphoma cells (2008)
  • 著者名/発表者名: Yano, H.
  • 雑誌名: Int J Cancer 120(9) ページ: 2052-2057
  • 査読あり
• [雑誌論文] Clinical significance of a blood eosinophilia in adult T-cell leuzkemia/lymphoma:a blood eosinophilia is a significant unfavorable prognostic factor (2008)
  • 著者名/発表者名: Utsunomiya, A.
  • 雑誌名: Leukemia Res. 31(7) ページ: 915-20
  • 査読あり
• [雑誌論文] Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor,on lymphoid malignant cells (2008)
  • 著者名/発表者名: Sanda, T.
  • 雑誌名: Leukemia 21(11) ページ: 2344-53
  • 査読あり
• [雑誌論文] The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer (2008)
  • 著者名/発表者名: Oguri, T
  • 雑誌名: Cancer Lett. 256(1) ページ: 112-9
  • 査読あり
• [雑誌論文] POU2AF1,an amplification target at 11q23,priomotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor,TNFRSF17. (2008)
  • 著者名/発表者名: Zhao, C.
  • 雑誌名: Oncogene 27(1) ページ: 63-75
  • 査読あり
• [雑誌論文] Defucosylated anti -CCR4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/ refractory mycosis fungoides and sezary syndrome. (2007)
  • 著者名/発表者名: Yano H, Ishida T, Inagaki A, Ishii T, Ding J, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
  • 雑誌名: Clin Cancer Res. 13 ページ: 6494-500
  • 査読あり
• [雑誌論文] Regulatory T-cell Function of adult T-cell leukemia/lymphoma cells. (2007)
  • 著者名/発表者名: Yano H, Ishida T, Inagaki A, Ishii T, Kusumoto S, Komatsu H, Iida S, Utsunomiya A, Ueda R
  • 雑誌名: Int J Cancer 120 ページ: 2052-7
  • 査読あり
• [雑誌論文] Japan Clinical Oncology Group Study JCOG9801. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. (2007)
  • 著者名/発表者名: Tsukasaki K, Utsunomiya A, Fukuda H, Shibata T, Fukushima T, Takatsuka Y, Ikeda S, Masuda M, Nagoshi H, Ueda R, Tamura K, Sano M, Momita S, Yamaguchi K, Kawano F, Hanada S, Tobinai K, Shimoyama M, Hotta T, Tomonaga M
  • 雑誌名: J Clin Oncol. 25 ページ: 5458-64
  • 査読あり
• [雑誌論文] Prognostic Significance of NPM-ALK Fusion Transcript Overexpression in ALK-positive Anaplastic Large Cell Lymphoma. (2007)
  • 著者名/発表者名: Li C, Takino H, Eimoto T, Ishida T, Inagaki A, Ueda R, Suzuki R, Yoshino T, Nakagawa A, Nakamura S, Inagaki H
  • 雑誌名: Mod Pathol 20 ページ: 648-55
  • 査読あり
• [雑誌論文] Clinical Significance of a blood eosinophilia in adult T-cell leukemia/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor. (2007)
  • 著者名/発表者名: Utsunomiya A, Ishida T, Inagaki A, Ishii T, Yano H, Komatsu H, Iida S, Yonekura K, Takeuchi S, Takatsuka Y, Ueda R
  • 雑誌名: Leuk Res. 31 ページ: 915-20
  • 査読あり
• [雑誌論文] MRP8/ABCC11 directly confers resistance to 5-fluorouracil (2007)
  • 著者名/発表者名: Oguri, T.
  • 雑誌名: Mol Cancer Ther 6(1) ページ: 122-7
  • 査読あり
• [雑誌論文] Long-term Follow-up of 14 Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia following Autologous Bone Marrow Transplantation in First Complete Remission (2007)
  • 著者名/発表者名: Mizuta, S.
  • 雑誌名: Int J Hematol 85(2) ページ: 140-5
  • 査読あり
• [雑誌論文] Immunoglobulin VH gene analysis in gastric MALT lymphomas (2007)
  • 著者名/発表者名: Sakuma, H.
  • 雑誌名: Mod Pathol 20(4) ページ: 460-466
  • 査読あり
• [雑誌論文] Differing distributions of CXCR3-andCCR4-positive cells among types of interstit 1 pneumonia associated with collagen vascular diseases (2007)
  • 著者名/発表者名: Shimizu, S.
  • 雑誌名: Virchows Arch 450(1) ページ: 51-58
  • 査読あり
• [雑誌論文] Prognostic significance of NPM-ALKfusion transcript overexpression inALK-positive anaplastic large-cell lymphoma (2007)
  • 著者名/発表者名: Li, C.
  • 雑誌名: Modern Pathology 20 ページ: 648-655
  • 査読あり
• [雑誌論文] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblast is leukemia: analysis by means of array-based comparative genomic hybridization (2007)
  • 著者名/発表者名: Tsuzuki, S.
  • 雑誌名: Cancer Sci. 98(5) ページ: 698-706
  • 査読あり
• [雑誌論文] Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study (2007)
  • 著者名/発表者名: Suzuki, T.
  • 雑誌名: Carcinogenesis 28(8) ページ: 1718-25
  • 査読あり
• [雑誌論文] Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas (2007)
  • 著者名/発表者名: Kondo, Y.
  • 雑誌名: Hepatol Res. 37(11) ページ: 974-83
  • 査読あり
• [雑誌論文] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. (2007)
  • 著者名/発表者名: Sanda, T.
  • 雑誌名: Haematologica 92(1) ページ: 115-120
• [雑誌論文] The CCR4 as a novel specific molecular target for immunotherapy in Hodgkin lymphoma. (2006)
  • 著者名/発表者名: Ishida T, Ishii T, Inagaki A, Yano H, Kusumoto S, Ri M, Komatsu H, Iida S, Inagaki H, Ueda R
  • 雑誌名: Leukemia 20 ページ: 2162-8
  • 査読あり
• [雑誌論文] CCR4 as a novel molecular target for immunotherapy of cancer. (2006)
  • 著者名/発表者名: Ishida T, Ueda R
  • 雑誌名: Cancer Sci. 97 ページ: 1139-46
  • NAID: 10019376772
  • 査読あり
• [雑誌論文] Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. (2006)
  • 著者名/発表者名: Ishida T, Ishii T, Inagaki A, Yano H, Komatsu H, Iida S, Inagaki H, Ueda R
  • 雑誌名: Cancer Res. 66 ページ: 5716-22
  • 査読あり
• [雑誌論文] Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors. (2006)
  • 著者名/発表者名: Inagaki A, Ishida T, Ishii T, Komatsu H, Iida S, Ding J, Yonekura K, Takeuchi S, Takatsuka Y, Utsunomiya A, Ueda R
  • 雑誌名: Int J Cancer 118 ページ: 3054-61
  • 査読あり
• [雑誌論文] Introduction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. (2006)
  • 著者名/発表者名: Sanda T, Asamitsu K, Ogura H, Iida S, Utsunomiya A, Ueda R., Okamoto, T
  • 雑誌名: Leukemia 20 ページ: 590-8
  • 査読あり
• [雑誌論文] CCR4 as a novel molecular targer for imminotherapy of Cancer (2006)
  • 著者名/発表者名: Ishida, T.
  • 雑誌名: Cancer Sci. 97(11) ページ: 1139-1146
• [雑誌論文] Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. (2006)
  • 著者名/発表者名: Ishida, T.
  • 雑誌名: Cancer Res. 66(11) ページ: 5716-5722
• [雑誌論文] Clinical significance of a blood eosinophilia in adult T-cell leukemia/lymphoma : blood eosinophilia is a significant unfavorable prognostic factor (2006)
  • 著者名/発表者名: Utsunomiya, A.
  • 雑誌名: Leuk Res. (in press)
• [雑誌論文] Differing distributions of CXCR3 -and CCR4-positive cells among types of interstitial pneumonia associated with collagen vascular diseases (2006)
  • 著者名/発表者名: Shimizu, S
  • 雑誌名: Virchows Arch. (in press)
• [雑誌論文] Expression of chemokine receptors CXCR3 and CCR4 in lymphocytes of Idiopathic nonspecific interstitisl pneumonia (2006)
  • 著者名/発表者名: Yoshinouchi, T.
  • 雑誌名: Respir Med. (in press)
• [雑誌論文] Immunoglobulin V(H) genes in thymic MALT lymphoma are biased toward a restricted repertoire and are frequently unmutated. (2006)
  • 著者名/発表者名: Yoshida, M
  • 雑誌名: J Pathol 208(3) ページ: 415-422
• [雑誌論文] Population pharmacokinetics of intravenous busulfan in patients undergoing hematopoietic stem cell plantation. (2006)
  • 著者名/発表者名: Takama, H.
  • 雑誌名: Bone Maarrow Transplant. 37(4) ページ: 345-351
• [雑誌論文] Role of ABCG2 as a biomarker for predicting resistance to CPT-11/SN-38 in lung cancer (2006)
  • 著者名/発表者名: Bessho, Y.
  • 雑誌名: Cancer Sci. 97(3) ページ: 192-198
• [雑誌論文] Introduction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor (2006)
  • 著者名/発表者名: Sanda, T.
  • 雑誌名: Leukemia 20(4) ページ: 590-598
• [雑誌論文] Genomewide Array-based comparative genomic Hybridization analysis of acute promyelocytic leukemia (2006)
  • 著者名/発表者名: Karnan, S.
  • 雑誌名: Genes Chromosomes Cancer 45(4) ページ: 420-425
• [雑誌論文] Clinical Significance of Serum Th1-, Th2- and Regulatory T cells-associated Cytokines in Adult T-cell Leukemia/Lymphoma : High Interleukin-5 and -10 levels are significant unfavorable prognostic factors. (2006)
  • 著者名/発表者名: Inagaki, A.
  • 雑誌名: Int J Cancer 118(12) ページ: 3054-3061
• [雑誌論文] The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer : a role of ABCC 5 in gemcitabine senseitivity (2006)
  • 著者名/発表者名: Oguri, T.
  • 雑誌名: Mol Cancer Ther. 5(7) ページ: 1800-1806
• [雑誌論文] Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density. (2005)
  • 著者名/発表者名: Niwa R, Sakurada M, Kobayashi Y, Uehara A, Matsushima K, Ueda R, Nakamura K, Shitara K
  • 雑誌名: Clin Cancer Res. 11 ページ: 2327-36
  • 査読あり
• [雑誌論文] Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: Roles of anoikis. (2005)
  • 著者名/発表者名: Aixinjueluo W, Furukawa K, Zhang Q, Hamamura K, Tokuda N, Yoshida S, Ueda R., Furukawa K.
  • 雑誌名: J Biol Chem. 280 ページ: 29828-36
  • 査読あり
• [雑誌論文] Production and characterization of an active single-chain variable fragment antibody recognizing CD25. (2005)
  • 著者名/発表者名: Muramatsu H, Yoshikawa K, Hayashi T, Takasu S, Kawada Y, Uchida K, Sato S, Takahashi T, Saga S, Ueda R
  • 雑誌名: Cancer Lett. 225 ページ: 225-36
  • 査読あり
• [雑誌論文] Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor. (2005)
  • 著者名/発表者名: Sanda, T., Ueda, R., et al.
  • 雑誌名: Clin Cancer Res. 11(5) ページ: 1974-1982
• [雑誌論文] Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density. (2005)
  • 著者名/発表者名: Niwa, R., Ueda, R., et al.
  • 雑誌名: Clin Cancer Res. 11 ページ: 2327-2336
• [雑誌論文] Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies : Roles of anoikis. (2005)
  • 著者名/発表者名: Aixinjueluo, W., Ueda, R., et al.
  • 雑誌名: J Biol Chem. 280(33) ページ: 29828-29836
• [雑誌論文] Multiple myeloma oncogene 1(MUM1)/interferon regulated factor 4(IRF4) upregulates monokine induced by interferon-gamma(MIG) gene expression in B-cell malignancy. (2005)
  • 著者名/発表者名: Uranishi, M., Iida, S., et al.
  • 雑誌名: Leukemia 19(8) ページ: 1471-1478
• [雑誌論文] Global real-time quantification/reverse transcription-polymerase chain reaction for detecting proto-oncogenes associated with 14q32 chromosomal translocation in multiple myeloma. (2005)
  • 著者名/発表者名: Tajima, E, Iida, S., et al.
  • 雑誌名: Haematologica 90(4) ページ: 559-562
• [雑誌論文] Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis. (2005)
  • 著者名/発表者名: Sanda, T, Ueda, R, et al.
  • 雑誌名: Leukemia 19 ページ: 901-909
• [雑誌論文] Production and characterization of an active single-chain variable fragment antibody recognizing CD25. (2005)
  • 著者名/発表者名: Muramatsu, H., Yoshikawa, K., et al.
  • 雑誌名: Cancer Letters 225(2) ページ: 225-236
• [雑誌論文] ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma : ARKS as a new molecular determinant of malignant multiple myeloma. (2005)
  • 著者名/発表者名: Suzuki, A., Iida, S., et al.
  • 雑誌名: Oncogene 24(46) ページ: 6936-6944
• [雑誌論文] Diffuse large B-cell lymphoma with extra Bcl-2 gene signals detected by FISH analysis is associated with a "non-germinal center phenotype" categolized by immunohistochemistry (2005)
  • 著者名/発表者名: Kusumoto, S., Ueda, R., et al.
  • 雑誌名: Am J Surg Pathol 29(8) ページ: 1067-1073
• [雑誌論文] Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. (2005)
  • 著者名/発表者名: Suzuki, T., Ueda, R., et al.
  • 雑誌名: Blood 106(8) ページ: 2854-2861
• [雑誌論文] The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells. (2005)
  • 著者名/発表者名: Oguri, T., Ueda, R., et al.
  • 雑誌名: Lung Cancer 49(3) ページ: 345-351
• [雑誌論文] Pharmacokinetic and pharmacodynamic comparision of fluoropyrimidine derivatives, capecitabine and 5'-deoxy-5-fluorouridine(5'-DFUR). (2005)
  • 著者名/発表者名: Ebi, H., Ueda, R., et al.
  • 雑誌名: Cancer Chemother Pharmacol 56 ページ: 205-211
• [雑誌論文] p16/INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis. (2005)
  • 著者名/発表者名: Takino, H., Ueda, R., et al.
  • 雑誌名: Mod Pathol. 18(9) ページ: 1187-1192
• [雑誌論文] Detection of the API2-MALT1 fusion transcripts in cytological speciments of patients with pulmonary mucosa-associated lymphoid tissue lymphoma. (2005)
  • 著者名/発表者名: Inagaki, H., Ueda, R., et al.
  • 雑誌名: Int J Hematol. 82(1) ページ: 59-62
• [雑誌論文] CC Chemokine Receptor4(CCR4) prositive diffuse large B-cell lymphoma involing the skin : A case report (2005)
  • 著者名/発表者名: Ishida, T., Ueda, R., et al.
  • 雑誌名: Int J Hematol. 82(2) ページ: 148-151
• [雑誌論文] Immunoglobulin V(H) genes in thymic MALT lymphoma are biased toward a restricted repertoire and are frequently unmutated. (2005)
  • 著者名/発表者名: Yoshida, M., Ueda, R., et al.
  • 雑誌名: J Pathol. 208(3) ページ: 415-422
• [雑誌論文] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model
  • 著者名/発表者名: Ito, A
  • 雑誌名: Cancer Immunol Immunother (印刷中)(in press)
  • 査読あり
• [雑誌論文] Differing distributions of CXCR3-and CCR4 -positive cells among typ es of interstitial pneumonia associated with collagen vascular diseases.
  • 著者名/発表者名: Shimizu, S.
  • 雑誌名: Virchows Arch. 450(1) ページ: 51-58
  • 査読あり
• [雑誌論文] VCAP-AMP-VECP Compared With Biweekly CHOP for Adult T-Cell Leu kemia-Lymphoma:Japan Clinical Oncology
  • 著者名/発表者名: Tsukasaki, K.
  • 雑誌名: J Clin Oncol 25(34) ページ: 5458-64
  • 査読あり
• [学会発表] CCR4 as a novel specific molecular target for immunotherapy in ATLL. (2010)
  • 著者名/発表者名: Ueda R
  • 学会等名: 8th AACR/JCB Conference
  • 発表場所: Waikoloa, Hawaii
• [学会発表] The current status and future directions of antibody-based cancer therapy (2008)
  • 著者名/発表者名: Ueda, R.
  • 学会等名: 第67回日本癌学会学術総会
  • 発表場所: 名古屋国際会議場
  • 年月日: 2008-10-30
• [学会発表] Phase I study of KW-0761, a Defucosylated Patients(Pts) with Adult T-Cell Leukemia-Lymphoma(ATL) or Peripheral T-Cell Lymphoma(PTCL): Updated Results. (2008)
  • 著者名/発表者名: Yamamoto K, Tobinai K, Utsunomiya A, Tsukasaki K, Uike N, Uozumi K, Tomonaga M, Matsushima K, Shitara K, Akinaga S, Ueda R
  • 学会等名: The 50th Annual Meeting of American Society of Hematology
  • 発表場所: San Francisco, CA, USA.