脳動脈瘤関連遺伝子の探索

• 研究課題/領域番号: 17019007
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東海大学 (2006-2009); 東京大学 (2005)
• 研究代表者: 井ノ上 逸朗 東海大学, 医学部, 教授 (00192500)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 32,200千円 (直接経費: 32,200千円); 2009年度: 6,400千円 (直接経費: 6,400千円); 2008年度: 6,400千円 (直接経費: 6,400千円); 2007年度: 6,400千円 (直接経費: 6,400千円); 2006年度: 6,500千円 (直接経費: 6,500千円); 2005年度: 6,500千円 (直接経費: 6,500千円)
• キーワード: 脳動脈瘤 / 疾患遺伝子 / ゲノム / 連鎖解析 / くも膜下出血 / アソシエーション・スタデイ / SNP / 関連遺伝子 / アソシエーション・スタディ / アソシエーシヨン・スタディ / 脳動脈流

研究概要

脳動脈瘤の破裂により重篤なくも膜下出血をきたす。我々はゲノム全域関連研究 (GWAS) を2段階走査法に基づいて実施している。また、これとは独立に、我々は3民族集団(フィンランド、オランダ、日本)を用いたGWASの共同研究に加わり、全コホートで共有される脳動脈瘤との関連座位を3本の染色体上に認めた(3座位のリスクアリルの集積的な効果として、3自由度一般化スコア検定でP=1.3x10-23を示した)。

研究成果

• [雑誌論文] Genome-wide association study of intracranial aneurysms identifies 5 risk loci. (2010)
  • 著者名/発表者名: Yasuno K, Bilguvar K, Bijlenga P, Kee ALS, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok Y, Niemela M, Tajima A, Frauberg M, Tamas D, Wirjatijasa F, Hata A, Jordi B, Oszvald A, Kasuya H, Gulam Z, Schoch B, Pankaj S, Stuer C, Roelof R, Beck J, Sola T, Ricciardi F, Aromaa A, Illig T, Schreiber S, Duijin CM, Berg LH, Claire P, Carole P, Roder C, Ozturk A, Gaal E, Jeremy W, Berg D, Geisen C, Christoph F, Paul S, Alex F, State MW, Wichmann HE, Breteler MMB, Wijmenga C, Mane S, Juan JE, Sandalcioglu IE, Meyer B, Raabe A, Daniel R, Jaaskelainen A, Hemesniemi J, Rinkel GJE, Zewnbutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Guenel M.
  • 雑誌名: Nat Genet 43 ページ: 420-425
  • 査読あり
• [雑誌論文] Genome-wide association study of intracranial aneurysms identifies three new risk ioci. (2010)
  • 著者名/発表者名: Yasuno K, Bilguvar K, Bijlenga P, Kee ALS, Krischek B, Auburger G, Simon M, et al.
  • 雑誌名: Nat Genet (in press)
  • 査読あり
• [雑誌論文] Gene expression profile for predicting survival in advanced-stage serous ovarian cancer across two independent databases. (2010)
  • 著者名/発表者名: Yoshihara K, Tajima A, Yahata T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M. Sueyoshi K, Fujiwaza H, Kudo Y, Koteta K, Masuzaki H, Tashiro H, Katabuchi H, Inoue I, Tanaka K.
  • 雑誌名: PLoS One 5
  • 査読あり
• [雑誌論文] Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-gamma in human mesangial cells in culture : possible involvement of RIG-I in the inflammation in lupus nephritis. (2010)
  • 著者名/発表者名: Imaizumi T, Tanaka H, Tajama A, Tsuruga K, Oki E, Sashinami H, Matsumiya T, Yoshida H, Inoue I, Ito E.
  • 雑誌名: Lupus (in press)
  • 査読あり
• [雑誌論文] Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. (2009)
  • 著者名/発表者名: Nakaoka H, Inoue I
  • 雑誌名: J Hum Genet 54 ページ: 615-623
  • NAID: 10030732221
  • 査読あり
• [雑誌論文] The phenotype and genotype experiment object model (PaGE-OM): a robust data structure for information related to DNA variation. (2009)
  • 著者名/発表者名: Brookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I, Kuroda M, Mizushima H, Thorisson GA, Dash D, Rajeevan H, Darlison MW, Woon M, Fredman D, Smith AV, Senger M, Naito K, Sugawara H
  • 雑誌名: Hum Mutat 30 ページ: 968-977
  • 査読あり
• [雑誌論文] Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort. (2009)
  • 著者名/発表者名: Ruigrok YM, Rinkel GJ, Wijmenga C, Kasuya H, Tajima A, Takahashi T, Hata A, Inoue I, Krischek B
  • 雑誌名: Cerebrovasc Dis 28 ページ: 131-134
  • 査読あり
• [雑誌論文] Genome-wide association database developed in the Japanese Integrated Database Project. (2009)
  • 著者名/発表者名: Koike A, Nishida N, Inoue I, Tsuji S, Tokunaga K.
  • 雑誌名: J Hum Genet 54 ページ: 543-546
  • NAID: 10030731798
• [雑誌論文] Further evidence for an association between mandibular height and the growth hoemone receptor genes in a Japanese population. (2009)
  • 著者名/発表者名: Tomoyasu Y, Yamaguchi T, Tajima A, Inoue I, Maki K.
  • 雑誌名: Am J Orthod Dentofacial Orthop 136 ページ: 536-541
  • 査読あり
• [雑誌論文] Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis. (2009)
  • 著者名/発表者名: Yoshihaza K, Tajima A, Komata D, Yamamoto T, Kodama S, Fujiwaza H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Inoue I, Tanaka K.
  • 雑誌名: Cancer Sci 100 ページ: 1421-1428
  • NAID: 10027193229
  • 査読あり
• [雑誌論文] Meta-analysis of genetic association studies : methodologies, between-study heterogeneity and winner's curse. (2009)
  • 著者名/発表者名: Nakaoka H, Inoue I.
  • 雑誌名: J Hum Genet 54 ページ: 615-623
  • NAID: 10030732221
  • 査読あり
• [雑誌論文] The phenotype and genotype experiment object model (PaGE-OM) : arobust data structure for information related to DNA variation. (2009)
  • 著者名/発表者名: Brookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I, Kuroda M, Mizushima H, Thorisson GA, Dash D, Rajeevan H, Dadison MW, Woon M, Fredman D, Smith AV, Senger M, Naito K, Sugawara H.
  • 雑誌名: Hum Mutat 30 ページ: 968-977
  • 査読あり
• [雑誌論文] Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort. (2009)
  • 著者名/発表者名: Ruigrok YM, Rinkel GJ, Wijmenga C, Kasuya H, Tajima A, Takahashi T, Hata A, Inoue I, Krischek B.
  • 雑誌名: Cerebrovasc Dis 28 ページ: 131-134
  • 査読あり
• [雑誌論文] Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population. (2009)
  • 著者名/発表者名: Kang E-H, Yamaguchi T, Tajima A, Nakajima T, Tomoyasu Y, Watanabe M, Yamaguchi M, Park S-B, Maki K, Inoue I.
  • 雑誌名: Arch Oral Biol 54 ページ: 556-562
  • 査読あり
• [雑誌論文] Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin intolerant asthma. (2009)
  • 著者名/発表者名: Sekigawa T, TajimaA, Hasegawa T, Hasegawa Y, Inoue H, Sano Y, Matsune S, Kurono Y, Inoue I.
  • 雑誌名: Clin Exp Allergy 39 ページ: 972-981
  • 査読あり
• [雑誌論文] Susceptibility loci for intracranial aneurysm in Europe and Japanese populations. (2008)
  • 著者名/発表者名: Bilguvar K, Yasuno K, Niemela M, Ruigrok YM, Fraunberg M, Duijn CM, Berg LH, Mane S, Mason C, Choi M, Gaaal E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MMB, Wijmenga C, State MW, Rinkel GJE, Hernesniemi J, Jaaskelainen JE, Palotie A, Inoue I, Lifton RP, Gunel M.
  • 雑誌名: Nat Genet 40 ページ: 1472-1477
  • 査読あり
• [雑誌論文] Evaluating the performance of Affymetrix SNP Array 6. 0 platform with 400 Japanese individuals. (2008)
  • 著者名/発表者名: Nishida N, Koike A, Tajima A, Ogasawara Y, Ishibashi Y, Uehara Y, Inoue I, Tokunaga K
  • 雑誌名: BMC Genomics 9 ページ: 431-431
  • 査読あり
• [雑誌論文] Network-based gene expression analysis of intracranial aneurysm tissue reveals role of antigen presenting cells. (2008)
  • 著者名/発表者名: Krischek B, Kasuya H, Tajima A, Akagawa H, Sasaki T, Yoneyama T, Ujiie H, Kubo O, Bonin M, Takakura K, Hori T, Inoue I
  • 雑誌名: Neuroscience 154 ページ: 1398-1407
  • 査読あり
• [雑誌論文] Gene expression in a canine basilar artery vasospasm model: a genome-wide network-based analysis. (2008)
  • 著者名/発表者名: Sasahara A, Kasuya H, Krischek B, Tajima A, Onda H, Sasaki T, Akagawa H, Hori T, Inoue I
  • 雑誌名: Neurosurg Rev 31 ページ: 283-290
  • 査読あり
• [雑誌論文] Identification of SNP markers for common CNV regions and association analysis of risk of subarachnoid aneurismal hemorrhage in Japanese population. (2008)
  • 著者名/発表者名: Bae JS, Cheong HS, Kim JO, Lee SO, Kim EM, Lee HW, Kim S, Kim JW, Cui T, Inoue I, Shin HD
  • 雑誌名: Biochem Biophys Res Commun 373 ページ: 593-596
  • 査読あり
• [雑誌論文] Large-scale analysis of Macaca fasciccularis transcripts and inference of genetic divergence between M. (2008)
  • 著者名/発表者名: Osada N, Hashimoto K, Kameoka Y, Hirata M, Tamura R, Uno Y, Inoue I, Hida M, Suzuki Y, Sugano S, Terao K, Kusuda J, Takahashi I
  • 雑誌名: fasciccularis and M. mulatta. BMC Genomics 9 ページ: 90-90
  • 査読あり
• [雑誌論文] Susceptibility loci for intracranial aneurysm in Europe and Japanese populations (2008)
  • 著者名/発表者名: Bilguvar K, Yasuno K, Niemela M, Ruigrok YM, Fraunberg M, Duijn CM, Berg LH, Mane S, M ason. C, Choi M, Gaaal E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MMB, Wijmenga C, State MW, Rinkel GJE, Hernesniemi J, Ja askelainen JE, Palotie A, Inoue I, Lifton RP, Gunel M.
  • 雑誌名: Nat Genet 40 ページ: 1472-1477
  • 査読あり
• [雑誌論文] Evaluating the performance of Affymetrix SNP Array 6.0 platform witl, 400 Japanese individuals (2008)
  • 著者名/発表者名: Nishida N, Koike A, Tajima A, Ogasawara Y, Ishibashi Y, Uehara Y, Inoue I, Tokunaga K.
  • 雑誌名: BMC Genomics 9 ページ: 431-431
  • 査読あり
• [雑誌論文] Genome-wide association analysis with selective genotyping identities candidate loci for adult height at 8q21.13 and 15q22. 33-q23 in Mongolians (2008)
  • 著者名/発表者名: Kimura T, Kobayashi T, Munkhbat B, Oyungerel G, Bilegtsaikhan T, Anar D, Jambaldorj J, Munkhsaikhan S, Munkhtuvshin N, Hayashi H, Oka A, Inoue I, Tnoko H.
  • 雑誌名: Hum Genet 123 ページ: 655-660
  • 査読あり
• [雑誌論文] I Network-based gene expression analysis of intracranial aneurysm tissue reveals role of antigen presenting cells (2008)
  • 著者名/発表者名: Krischek B, Kasuya H, Tajima A, Akagawa H, Sasaki T, Yoney ama T, Ujiie H, Kubo O, Bonin M, Takakura K, Hori T, Inoue I
  • 雑誌名: Neuroscience 154 ページ: 1398-1407
  • 査読あり
• [雑誌論文] Gene expression in a canine basilar artery vasospasm model : a genome-wide network-based analysis (2008)
  • 著者名/発表者名: Sasahara A, Kasuya H, Krischek B, Tajima A, Onda H, Sasaki T, Akagawa H, Hori T, Inoue I.
  • 雑誌名: Neurosurg Rev 31 ページ: 283-290
  • 査読あり
• [雑誌論文] Identification of SNP markers for common CNV regions and association analysis of risk of subarachnoid aneurismal hemorrhage in Japanese population (2008)
  • 著者名/発表者名: Bae JS, Cheong HS, Kim JO, Lee SO, Kim EM, Lee HW, Kim S, Kim JW, Cui T, Inoue I, Shin HD.
  • 雑誌名: Biochem Biophys Res Commun 373 ページ: 593-596
  • 査読あり
• [雑誌論文] Large-scale analysis of Macaca fasciccularis transcripts and inference of genetic divergence between M. fasciccularis and M. mulatta (2008)
  • 著者名/発表者名: Osada N, Hashimoto K, Kameoka Y, Hirata M, Tamura R, Uno Y, Inoue I, Hida M, Suzuki Y, Sugano S, Terao K, Kusuda J, Takahashi I.
  • 雑誌名: BMC Genomics 9 ページ: 90-90
  • 査読あり
• [雑誌論文] Large-scale analysis of Macaca fasciccularis transcripts and inference of genetic divergence between M. fasciccularis and M. mulatta. (2008)
  • 著者名/発表者名: Osada, N・Hashimoto, K・Kameoka, Y・Hirata, M・Tamura, R・Uno, Y・Inoue, I・Hida, M・Suzuki, Y・Sugano, S・Terao, K・Kusuda, J・Takahashi, I.
  • 雑誌名: BMC Genomics 9 ページ: 90-90
• [雑誌論文] Increased expression of ephrin A1 in brain arteriovenous malformation. (2007)
  • 著者名/発表者名: Sasahara A, Kasuya H, Akagawa H, Ujiie H, Kubo O, Sasaki T, Onda H, Sakamoto Y, Krischek B, Hori T, Inoue I
  • 雑誌名: Neurosurg Rev 30 ページ: 299-305
  • 査読あり
• [雑誌論文] Gene expression changes during the chondrogenic differentiation of human mesenchymal stem cells (2007)
  • 著者名/発表者名: Ikeda R, Tsukahara S, Yoshida K, Inoue I
  • 雑誌名: J Biol Sci 7 ページ: 729-736
  • 査読あり
• [雑誌論文] Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (2007)
  • 著者名/発表者名: Akagawa H, Narita A, Yamada H, Tajima A, Krischek B, Kasuya H, Hori T, Kubota M, Saeki N, Hata A, Mizutani M, Inoue I
  • 雑誌名: Hum Genet 121 ページ: 377-387
  • 査読あり
• [雑誌論文] Increased expression of ephrin A1 in brain arteriovenous malformation. (2007)
  • 著者名/発表者名: Sasahara, A・Kasuya, H・Akagawa, H・Ujiie, H・Kubo, O・Sasaki, T・Onda, H・Sakamoto, Y・Krischek, B・Hori, T・Inoue, I.
  • 雑誌名: Neurosurg Rev 30 ページ: 299-305
• [雑誌論文] Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (2007)
  • 著者名/発表者名: Akagawa, H・Narita, A・Yamada, H・Tajima, A・Krischek, B・Kasuya, H・Hori, T・Kubota, M・Seki, N・Hata, A・Mizutani, M・Inoue, I.
  • 雑誌名: Hum Genet 121 ページ: 377-387
• [雑誌論文] Systematic screening oflyssy1 oxidase-like(LOXL)family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms (2007)
  • 著者名/発表者名: Akagawa H, Narita A, Yamada H, Hata A, Inoue I
  • 雑誌名: Hum Genet (in press)
• [雑誌論文] The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. (2006)
  • 著者名/発表者名: Krischek B, Akagawa H, Tajima A, Narita A, Kasuya H, Hori T, Inoue I
  • 雑誌名: Cerebrovasc Dis 23 ページ: 46-49
  • 査読あり
• [雑誌論文] Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. (2006)
  • 著者名/発表者名: Krischek B, Kasuya H, Akagawa H, Tajima A, Narita A, Onda H, Hori T, Inoue I
  • 雑誌名: J Neurosurg 105 ページ: 717-722
  • 査読あり
• [雑誌論文] A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms. (2006)
  • 著者名/発表者名: Akagawa H, Tajima A, Sakamoto Y, Krischek B, Yoneyama T, Kasuya H, Onda H, Hori T, Kubota M, Machida T, Saeki N, Hata A, Hashiguchi K, Kimura E, Kim C-J, Yang T-K, Lee J-Y, Kimm K, Inoue I.
  • 雑誌名: Hum Mol Genet 15 ページ: 1722-1734
  • 査読あり
• [雑誌論文] Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm? (2006)
  • 著者名/発表者名: Krischek B, Narita A, Akagawa H, Kasuya H, Tajima A, Onda H, Yoneyama T, Hori T, Inoue I
  • 雑誌名: J Hum Genet 51 ページ: 491-494
  • NAID: 10019168190
  • 査読あり
• [雑誌論文] A haplotype spanning two genes, ELN and LIML1, decreases their transcripts and confers susceptibility to intracranial aneurysms (2006)
  • 著者名/発表者名: Akagawa H, Tajima A, Sakamoto Y, Kimm K, Inoue I
  • 雑誌名: Hum Mol Genet 15 ページ: 1722-1734
• [雑誌論文] The alanine/trheonine polymorphism of the alpha-1-anitichymotrypsin (SERPINA3)gene and ruptured intracranial aneurysms in the Japanese population (2006)
  • 著者名/発表者名: Krischek B, Akagawa H, Tajima A, Hori T, Inoue I
  • 雑誌名: Cerebrovasc Dis 23 ページ: 46-49
• [雑誌論文] Genetics of intracranial aneurysm (2006)
  • 著者名/発表者名: Krischek B, Inoue I
  • 雑誌名: J Hum Genet 51 ページ: 587-594
  • NAID: 10017989475
• [雑誌論文] Zebrafish numb homologue phylogenetic evolution and involvement in regulation of eft-right asymmetry (2006)
  • 著者名/発表者名: Niikura Y, Tabata Y, Tajima A, Inoue I
  • 雑誌名: Mech Dev 123 ページ: 407-414
• [雑誌論文] Collagen Morphology Is Not Associated With the Ala549Pro Polymorphism of the COL1A2 Gene. (2005)
  • 著者名/発表者名: Krischek B, Kasuya H, Inoue I
  • 雑誌名: Stroke 36 ページ: 2068-2069
  • 査読あり
• [雑誌論文] Endothelial nitric oxidase synyhase T-786C single nucleotide polymorphism is not a factor influencing aneurysm size. (2005)
  • 著者名/発表者名: Akagawa H, Kasuya H, Onda H, Yoneyama T, Choi K-Y, Lee W-J, Hong S-W, Yang T-K, Kim C-J, Hori T, Inoue I
  • 雑誌名: J Neurosurgery 95 ページ: 622-625
  • 査読あり
• [雑誌論文] Evidence for natural selection in the HAVCR1 gene : high degree of amino-acid variability in the mucin domain of human HAVCR1 protein. (2005)
  • 著者名/発表者名: Nakajima T, Wooding S, Satta Y, Jinnai N, Goto S, Hayasaka I, Saitou N, Guan-Jun J, Tokunaga K, Jorde LB, Emi M, Inoue I.
  • 雑誌名: Genes Immun 6 ページ: 398-406
• [雑誌論文] PLZF promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1. (2005)
  • 著者名/発表者名: Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa-K, Inoue I.
  • 雑誌名: J Biol Chem 280 ページ: 8523-8530
• [雑誌論文] Genome-wide linkage analysis of mandibular prognathism in Korean and Japanese patients. (2005)
  • 著者名/発表者名: Yamaguchi T, Park S-B, Narita A, Maki K, Inoue I.
  • 雑誌名: J Dent Res 84 ページ: 255-259
• [雑誌論文] Differential Effects of chromosome 9p21 variation on subphenotypes of intracranial aneurysm: site distribution.
  • 著者名/発表者名: Nakaoka H, Takahashi T, Akiyama K, Cui T, Tajima A, Krischek B, Kasuya H, Hata A, Inoue I
  • 雑誌名: Stroke (in press)
  • 査読あり
• [雑誌論文] Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort.
  • 著者名/発表者名: Krischek B, Tajima A, Akagawa H, Narita A, Ruigrok Y, Rinkel G, Wijmenga C, Feigi GC, Kim CJ, Hori T, Tatagiba M, Kasuya H, Inoue I
  • 雑誌名: Neuroscience (in press)
  • 査読あり
• [雑誌論文] Positional effects of polymorphisms in probe-target sequences on genoplot images of oligonucleotide microarrays.
  • 著者名/発表者名: Cui TL, Nakaoka H, Akiyama K, Kamura H, Hosomichi K, Bae J, Cheong H, Shin H, Yada T, Inoue I
  • 雑誌名: Genet Mol Res (in press)
  • 査読あり
• [雑誌論文] Analysis of expressed sequence tags from liver in cynomolgus monkey (Macaca fasciccularis): A systematic identification of drug-metabolizing enzyme genes
  • 著者名/発表者名: Uno, Y・Suzuki, Y・Wakaguri, H・Sakamoto, Y・Sano, H・Osada, N・Hashimoto, K・Sugano, S・Inoue, I.
  • 雑誌名: FEBS Let (In press)
• [雑誌論文] Integration of hepatitis B virus DNA into the MPP (mixed lineage leukemia) 4 gene and rearrangements of MLL4 in human hepatocellular carcinoma cells.
  • 著者名/発表者名: Saigo, K・Yoshida, K・Ikeda, R・Sakamoto, Y・Murakami, Y・Urashima, T・Asano, T・Kenmochi, T・Inoue, I.
  • 雑誌名: Hum Mutat (In press)
• [雑誌論文] Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?
  • 著者名/発表者名: Krischek B, Narita A, Akagawa H, Kasuya H, Tajima A, Onda H, Yoneyama T, Hori T, Inoue I.
  • 雑誌名: J Hum Genet in press
  • NAID: 10019168190
• [雑誌論文] Genetics of intracranial aneurysm.
  • 著者名/発表者名: Krischek B, Inoue I.
  • 雑誌名: J Hum Genet in press
  • NAID: 10017989475
• [雑誌論文] Zebrafish numb homologue : phylogenetic evolution and involvement in regulation of left-right asymmetry.
  • 著者名/発表者名: Niikura Y, Tabata Y, Tajima A, Inoue I, Arai K, Watanabe S.
  • 雑誌名: Mech Dev in press
• [備考] 日本経済新聞2006年10月9日「脳卒中予防へ成果-くも膜下出血、関連遺伝子を同定-」
• [備考] NHKニュース2008年11月10日「くも膜下出血に関連遺伝子」
• [備考] 毎日新聞2008年11月10日「くも膜下出血:発症高める脳動脈瘤の遺伝子領域特定」
• [備考] 日本経済新聞200年11月10日「脳動脈瘤-原因遺伝子3種解明東海大、リスク最大7倍に」
• [備考] 科学新聞2008年11月14日「脳動脈瘤解明に道-日米胸中の遺伝子多型同定」