アルツハイマー病の関連遺伝子探索研究

• 研究課題/領域番号: 17019043
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 大阪大学
• 研究代表者: 武田 雅俊 大阪大学, 医学系研究科, 教授 (00179649)
• 研究分担者: 森原 剛史 大阪大学, 医学系研究科, 助教 (90403196) ; 田中 稔久 大阪大学, 医学系研究科, 講師 (10294068) ; 赤津 裕康 医療法人さわらび会福祉村病院, 長寿医学研究所, 副所長 (00399734) ; 前田 潔 神戸大学, 医学系研究科, 教授 (80116251) ; 新井 平伊 順天堂大学, 医学部, 教授 (50167988) ; 中島 健二 鳥取大学, 医学部, 教授 (70144673) ; 山縣 英久 愛媛大学, 医学系研究科, 講師 (00304618) ; 田口 敬子 愛媛大学, 医学系研究科, 助教 (20457378) ; 紙野 晃人 大阪大学, 医学系研究科, 助手 (40307955)
• 連携研究者: 柴田 展人 順天堂大学, 医学部, 講師 (50365615) ; 山本 泰司 神戸大学, 医学系研究科, 講師 (00324921) ; 和田 健二 愛媛大学, 医学系研究科, 講師 (60346351) ; 紙野 晃人 大阪大学, 大学院・医学系研究科, 講師 (40307955) ; 木村 亮 大阪大学, 大学院・医学系研究科, 大学院生 ; 林 紀行 大阪大学, 医学系研究科, 大学院生 ; 横小路 美貴子 大阪大学, 医学系研究科, 大学院生
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 85,700千円 (直接経費: 85,700千円); 2009年度: 15,000千円 (直接経費: 15,000千円); 2008年度: 15,000千円 (直接経費: 15,000千円); 2007年度: 18,400千円 (直接経費: 18,400千円); 2006年度: 18,700千円 (直接経費: 18,700千円); 2005年度: 18,600千円 (直接経費: 18,600千円)
• キーワード: アルツハイマー病 / 多因子疾患 / ゲノム / Dynamin2 / アミロイドβ蛋白 / APPトランスジェニックマウス / リスク遺伝子 / SORL1 / KIBRA / 罹患同胞対 / ダイナミン / 第21染色体 / 第12染色体短腕 / アポリポ蛋白E / 第八因子 / SURB遺伝子 / アポリポ蛋白C1 / アポリポ蛋白C2

研究概要

異なるアプローチ法を用いながらアルツハイマー病関連遺伝子候補を探索した。DYRK1Aは21番染色体のゲノムスキャンによって同定され、発現解析と機能解析も行われた。DNM2も関連解析のみならず発現および機能解析を行った。逆に脳の発現解析で候補を絞り、ゲノムで関連がみられた遺伝子としてPPP2RBを同定した。一方、ヒト検体よりも厳密な解析が容易に行える疾患モデル動物を用いたアルツハイマー病の中心病理であるアミロイド病理を修飾する遺伝子のスクリーニングも行った。

研究成果

• [雑誌論文] Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism. (2009)
  • 著者名/発表者名: Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik MG, Kamino K, Takeda M.
  • 雑誌名: Biochem Biophys Res Commun. 379(3) ページ: 691-5
  • 査読あり
• [雑誌論文] Dementia in the Rural Island Town of Ama-cho, Japan. (2009)
  • 著者名/発表者名: Wada-Isoe K, Uemura Y, Suto Y, Doi K, Imamura K, Hayashi A, Kitayama M, Watanabe Y, Adachi Y Nakashima K
  • 雑誌名: Neuroepidemiology. 32(2) ページ: 101-106
  • 査読あり
• [雑誌論文] Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population. (2009)
  • 著者名/発表者名: Shibata N, Ohnuma T, Baba H, Arai H.
  • 雑誌名: Dement Geriatr Cogn Disord. 28(4) ページ: 325-9
  • 査読あり
• [雑誌論文] ssociation between polymorphisms of heme oxygenase 1 and 2 and Alz heimer's disease in a Japanese population. (2009)
  • 著者名/発表者名: Shibata N, Ohnuma T, Baba H, Arai H.
  • 雑誌名: Dement Geriatr Cogn Disord. 27(3) ページ: 273-7
  • 査読あり
• [雑誌論文] Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein. (2009)
  • 著者名/発表者名: Sadik G, Tanaka T., Kato K, Yanagi K, Kudo T, Takeda M
  • 雑誌名: Commun 22 383(1) ページ: 37-41
  • 査読あり
• [雑誌論文] Involvement of puromycine-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau. (2009)
  • 著者名/発表者名: Yanagi K, Tanaka T, Kato K, Sadik G,, Morihara T, Kudo T, Takeda M
  • 雑誌名: Psycogeriatrics (in press)
  • 査読あり
• [雑誌論文] Novel therapeutic strategies for neurodegenerative disease. (2009)
  • 著者名/発表者名: Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M.
  • 雑誌名: Psychogeriatrics. 9 ページ: 103-109
  • NAID: 10025639046
  • 査読あり
• [雑誌論文] Prevention of psychiatric illness in the elderly I -Path to Prevention of Dementia (2009)
  • 著者名/発表者名: Tanaka T, Kazui H, Sadik G, Tanimukai H, Tagami S, Morihara T, Okochi M, Kudo K, Takeda M.
  • 雑誌名: Psychogeriatrics 9 ページ: 111-115
  • NAID: 10027274850
  • 査読あり
• [雑誌論文] Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein. (2009)
  • 著者名/発表者名: Ito S, Nakaso K, Imamura K, Takeshima T, Nakashima K
  • 雑誌名: Neurosci Res. inpress(in press)
  • 査読あり
• [雑誌論文] Validation of the Parkinson's disease sleep scale in Japanese patients: a comparison study using the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale and Polysomnography. (2009)
  • 著者名/発表者名: Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K
  • 雑誌名: J Neurol Sci. Dec 15;287(1-2) ページ: 36-40
  • 査読あり
• [雑誌論文] Long-term prognosis of patients with large subcortical infarctions. (2009)
  • 著者名/発表者名: Suto Y, Nakayasu H, Maeda M, Kusumi M, Kowa H, Awaki E, Saito J, Nakashima K.
  • 雑誌名: Eur Neurol. 62(5) ページ: 304-10
  • 査読あり
• [雑誌論文] Aassessment of dementia in patients with multiple system atrophy Kitayama M (2009)
  • 著者名/発表者名: Wada-Isoe K, Irizawa Y, Nakashima K.
  • 雑誌名: Eur J Neurol. 16(5) ページ: 589-94
  • 査読あり
• [雑誌論文] Changes in prevalence and incidence of Parkinson's disease in Japan during a quarter of a century. (2009)
  • 著者名/発表者名: Yamawaki M, Kusumi M, Kowa H, Nakashima K.
  • 雑誌名: Neuroepidemiology. 32(4) ページ: 263-9
  • 査読あり
• [雑誌論文] Neuropsychological profile of dementia with Lewy bodies (2009)
  • 著者名/発表者名: Haruhiko Oda, Yasuji Yamamoto, Kiyoshi Maeda
  • 雑誌名: PSYCHOGERIATRICS ページ: 85-90
  • NAID: 10025638921
  • 査読あり
• [雑誌論文] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. (2009)
  • 著者名/発表者名: Sadik G, Tanaka T, Kato K, Yamamori H, Nessa BN, Morihara T, Takeda M.
  • 雑誌名: J Neurochem 108(1) ページ: 33-43
  • 査読あり
• [雑誌論文] Association Study of RGS2 Gene Polymorphisms with Panic Disorder in Japanese. (2009)
  • 著者名/発表者名: Mouri K, Hishimoto A, Fukutake M, Shirakawa O, Nishiguchi N, Maeda K.
  • 雑誌名: Kobe Journal of Medical Sciences (in press)
  • NAID: 110007614321
  • 査読あり
• [雑誌論文] TPH2 is not a susceptibility gene for suicide in Japanese population. (2009)
  • 著者名/発表者名: Mouri K, * *_Hishimoto A, _ Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 33(8) ページ: 1546-1550
  • 査読あり
• [雑誌論文] Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease. (2009)
  • 著者名/発表者名: Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K.
  • 雑誌名: Biochem Biophys Res Commun. 379(2) ページ: 272-6
  • 査読あり
• [雑誌論文] The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. (2009)
  • 著者名/発表者名: Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, et al
  • 雑誌名: EMBO Mol Med. Jul;1(4): ページ: 223-235
  • 査読あり
• [雑誌論文] Destruxin E decreases Beta-amyloid generation by reducing colcalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor (2009)
  • 著者名/発表者名: Itoh N, Okochi _M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, et al
  • 雑誌名: Neurodegener Dis. 2009 6(5-6): ページ: 230-239
  • 査読あり
• [雑誌論文] SORL1 is genetically associated with Alzheimer disease in a Japanese population (2009)
  • 著者名/発表者名: Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M.
  • 雑誌名: Neurosci Lett 461(2): ページ: 177-180
  • 査読あり
• [雑誌論文] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein : implications for the mechanism of tau aggregation (2009)
  • 著者名/発表者名: Sadik G, Tanaka T, Kato K, Yamamori H, Nessa BN, Morihara T, Takeda M.
  • 雑誌名: J Neurochem 108(1): ページ: 33-43
  • 査読あり
• [雑誌論文] Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population (2009)
  • 著者名/発表者名: Shibata N, Ohnuma T, Baba H, Arai H.
  • 雑誌名: Dement Geriatr Cogn Disord. 28 ページ: 325-329
  • 査読あり
• [雑誌論文] No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alz heimer's disease in a Japanese population. (2009)
  • 著者名/発表者名: Shibata N, Ohnuma T, Baba H, Arai H.
  • 雑誌名: Dement Geriatr Cogn Disord. 27(3) ページ: 273-277
  • 査読あり
• [雑誌論文] Novel therapeutic strategies for neurodegenerative disease (2009)
  • 著者名/発表者名: Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M.
  • 雑誌名: Psychogeriatrics. 9 ページ: 103-109
  • NAID: 10025639046
  • 査読あり
• [雑誌論文] Long-term prognosis of patients with large subcortical infarctions. (2009)
  • 著者名/発表者名: Suto Y, Nakayasu H, Maeda M, Kusumi M, Kowa H, Awaki E, Saito J, Nakashima
  • 雑誌名: Neurol 62(5): ページ: 304-310
  • 査読あり
• [雑誌論文] Aassessment of dementia in patients with multiple system atrophy (2009)
  • 著者名/発表者名: Kitayama M, Wada-Isoe K, Irizawa Y, Nakashima K.
  • 雑誌名: Eur J Neurol. 16(5): ページ: 589-594
  • 査読あり
• [雑誌論文] Association Study of RGS2 Gene Polymorphisms with Panic Disorder in (2009)
  • 著者名/発表者名: Mouri K,Hishimoto A, Fukutake M, Shirakawa O, Nishiguchi N, Maeda K.
  • 雑誌名: Journal of Medical Sciences (in press)
  • 査読あり
• [雑誌論文] TPH2 is not a susceptibility gene for suicide in Japanese population (2009)
  • 著者名/発表者名: Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry/ 33(8) ページ: 1546-1550
  • 査読あり
• [雑誌論文] Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism (2009)
  • 著者名/発表者名: Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik MG, Kamino K, Takeda M
  • 雑誌名: Biochem Biophys Res Commun 379(3) ページ: 691-5
  • 査読あり
• [雑誌論文] Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease (2009)
  • 著者名/発表者名: Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K.
  • 雑誌名: Biochem Biophys Res Commun 379(2) ページ: 272-6
  • 査読あり
• [雑誌論文] Association between quality of life of demented patients and professional knowledge of care workers. (2008)
  • 著者名/発表者名: Kazui H, Harada K, Eguchi YS, Tokunaga H, Endo H, Takeda M.
  • 雑誌名: J Geriatr Psychiatry Neurol 21(1) ページ: 72-8
  • 査読あり
• [雑誌論文] Hemispatial visual defect in Alzheimer's disease. (2008)
  • 著者名/発表者名: Oda H, Ohkawa S, Maeda K
  • 雑誌名: NEUROCASE 14(2) ページ: 141-146
  • 査読あり
• [雑誌論文] The neuropsychological profile in dementia with Lewy bodies and Alzheimer's deisease (2008)
  • 著者名/発表者名: H Oda, Y Yamamoto, K Maeda
  • 雑誌名: Int J Geriaty Psychiatry 23 ページ: 1-7
  • 査読あり
• [雑誌論文] A molecular chaperone inducer protects neurons from ER stress. (2008)
  • 著者名/発表者名: Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M.
  • 雑誌名: Cell Death Differ. 15(2) ページ: 364-75
  • 査読あり
• [雑誌論文] Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-ε4 carriers Aidaralieva (2008)
  • 著者名/発表者名: N, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, et al
  • 雑誌名: J Hum Genet 53(4) ページ: 296-302
  • 査読あり
• [雑誌論文] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease. (2008)
  • 著者名/発表者名: Taniguchi, M., Okayama, Y., Hashimoto, Y., Kitaura, M., Jimbo, D., Wakutani, Y., Wada-Isoe, K., Nakashima, K., Akatsu, H., Furukawa, K., Arai, H., Urakami, K. Dement
  • 雑誌名: Geriatr Cogn Disord. 26(2) ページ: 117-22
  • 査読あり
• [雑誌論文] A functional polymorphism of theμ-opioid receptor gene is associated with completed suicides Akitoyo Hishimoto (2008)
  • 著者名/発表者名: Huxing Cui, Kentarou Mouri, Hideyuki Nushida, Yasuhiro Ueno, Kiyoshi Maeda, Osamu Shirakawa
  • 雑誌名: J Neural Transmission 115 ページ: 531-536
  • 査読あり
• [雑誌論文] Association of RGS2 Gene Polymorphisms with Suicide and Increased RGS2 Immunoreactivity in the Postmortem Brain of Suicide Victims (2008)
  • 著者名/発表者名: Huxing Cui, Naoki Nishiguchi, Elene Ivleva, Masaya Yanagi, Masaaki Fukutake, H Nushida, Y Ueno, Noboru Kitamura, Kiyoshi Maeda, Osamu Shirakawa
  • 雑誌名: Neuropsychopharmacology 33(7) ページ: 1537-1544
  • 査読あり
• [雑誌論文] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (2008)
  • 著者名/発表者名: Masaya Yanagi, Takeshi Hashimoto, Noboru Kitamura, Masaaki Fukutake, Osamu Komure, Naoki Nishiguchi, Toshio Kawamata, Kiyoshi Maeda, Osamu Shirakawa
  • 雑誌名: Schizophr Res 100 ページ: 291-301
  • 査読あり
• [雑誌論文] of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females. (2008)
  • 著者名/発表者名: Fukutake M, Hishimoto A, Nishiguchi N, Nushida H, Ueno Y, Shirakawa O, Maeda K. Prog
  • 雑誌名: Neuropsychopharmacol Biol Psychiatry. 32(6) ページ: 1428-33
  • 査読あり
• [雑誌論文] Event-related synchronization of alpha activity in early Alzheimer's disease and mild cognitive impairment: an MEG study combining beamformer and group comparison. (2008)
  • 著者名/発表者名: Kurimoto R, Ishii R, Canuet L, Ikezawa K, Azechi M, Iwase M, Yoshida T, Kazui H, Yoshimine T, Takeda M.
  • 雑誌名: Neurosci Lett. 443(2) ページ: 86-9
  • 査読あり
• [雑誌論文] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 (2008)
  • 著者名/発表者名: Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, et al
  • 雑誌名: Mol Cell Biol 28(1) ページ: 165-76
  • 査読あり
• [雑誌論文] Association of visual hallucinations with reduction of MIBG cardiac uptake in Parkinson's disease. (2008)
  • 著者名/発表者名: Kitayama M, Wada-Isoe K, Irizawa Y, Nakashima K.
  • 雑誌名: J Neurol Sci 264(1-2) ページ: 22-6
  • 査読あり
• [雑誌論文] Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. (2008)
  • 著者名/発表者名: Kubo Y, Kazui H, Yoshida T, Kito Y, Kimura N, Tokunaga H, Ogino A, Miyake H, Ishikawa M, Takeda M.
  • 雑誌名: Dement Geriatr Cogn Disord 25(1) ページ: 37-45
  • 査読あり
• [雑誌論文] Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. (2008)
  • 著者名/発表者名: Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA.
  • 雑誌名: J Pharmacol Exp Ther 326(1) ページ: 196-208
  • 査読あり
• [雑誌論文] Possible association between SORL1 and Alzheimer disease? Reanalysing the data of Shibata, et al. (2008)
  • 著者名/発表者名: Lee JH, Shibata N, Cheng R, Mayeux R.
  • 雑誌名: Dement Geriatr Cogn Disord. 26(5) ページ: 482-482
  • 査読あり
• [雑誌論文] Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. (2008)
  • 著者名/発表者名: Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H.
  • 雑誌名: Dement Geriatr Cogn Disord 26(2) ページ: 161-4
  • 査読あり
• [雑誌論文] Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase. (2008)
  • 著者名/発表者名: Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
  • 雑誌名: Neurodegener Dis 5(3-4) ページ: 160-2
  • 査読あり
• [雑誌論文] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease (2008)
  • 著者名/発表者名: Taniguchi M, Okayama Y, Hashimoto Y, Kitaura M, Jimbo D, Wakutani Y, Wada-Isoe K, Nakashima K, Akatsu H, Furukawa K. Arai H. Urakami K.
  • 雑誌名: Dement Geriatr Cogn Disord 26(2) ページ: 117-22
  • 査読あり
• [雑誌論文] A functional polymorphism of the μ-opioid receptor gene is associated with completed suicides (2008)
  • 著者名/発表者名: Akitoyo Hishimoto, Huxing Cui, Kentarou Mouri, Hideyuki Nushida, Yasuhiro Ueno. Kivoshi Maeda, Osamu Shirakawa
  • 雑誌名: J Neural Transmission 115 ページ: 531-536
  • 査読あり
• [雑誌論文] Association of RGS2 Gene Polymorphisms with Suicide and Increased RGS2 Immunoreactivity in the Postmortem Brain of Suicide Victims (2008)
  • 著者名/発表者名: Huxing Cui, Naoki Nishiguchi, Elene Ivleva, Masayi Yanagi, Masaaki Fukutake, H Nushida, Y Ueno, Noboru Kitamura, Kiyoshi Maeda, Osamu Shirakawa
  • 雑誌名: Neuropsychopharmacology 33(7) ページ: 1537-1544
  • 査読あり
• [雑誌論文] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia (2008)
  • 著者名/発表者名: Masaya Yanagi, Takeshi Hashimoto, Noboru Kitamura, Masaaki Fukutake, Osamu Komure, Naoki Nishiguchi, Toshio Kawamata, Kiyoshi Maeda, Osamu Shirakawa
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• [雑誌論文] Possible association between SORL1 and Alzheimer diseae? Reanalysing the data of Shibata et.al. (2008)
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• [雑誌論文] Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population (2008)
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• [雑誌論文] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. (2007)
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• [雑誌論文] Peripheral ethanolamine plasmalogen deficiency: a logical cau sative factor in Alzheimer's disease and dementia. (2007)
  • 著者名/発表者名: Goodenowe, DB・Cook, LL・Liu, J・Lu, Y・Jayasinghe, DA・Ahiahonu, PW・Heath, D・Yamazaki, Y・Flax, J・Krenitsky, KF・Sparks, DL・Lermer, A・Friedland, RP・Kudo, T・Kamino, K・Morihara, T・Takeda, M・Wood, PL.
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• [雑誌論文] Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, asorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. (2007)
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• [雑誌論文] The Tottori (D7N) and English (H6R) familial Alzheimer dise ase mutations accelerate Abeta fibril formation without increasing protofibril formation. (2007)
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• [雑誌論文] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β amyloid production and tau phosphorylation in Alzheimer disease. (2007)
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• [雑誌論文] アルツハイマー病のゲノム解析 (2006)
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  • 著者名/発表者名: Taguchi K, Yamagata H, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T.
  • 雑誌名: Ann Neurol 57(4) ページ: 585-8
  • 査読あり
• [雑誌論文] Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura. (2005)
  • 著者名/発表者名: Kowa H, Fusayasu E, Ijiri T, Ishizaki K, Yasui K, Nakaso K, Kusumi M, Takeshima T, Nakashima K.
  • 雑誌名: Neuroscience Letters 374 ページ: 129-131
• [雑誌論文] Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. (2005)
  • 著者名/発表者名: Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S.
  • 雑誌名: Journal of Neural Transmission 112 ページ: 703-711
• [雑誌論文] Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. (2005)
  • 著者名/発表者名: Shibata N, Ohnuma T, Higashi S, Usui C, Ohkubo T, Kitajima A, Ueki A, Nagao M, Arai H.
  • 雑誌名: Neurobiology of Aging 26・7 ページ: 1011-1014
• [雑誌論文] Identification of hippocampus-related candidate genes for Alzheimer's disease. (2005)
  • 著者名/発表者名: Taguchi K, Yamagata H, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T.
  • 雑誌名: Annals of Neurology 57・4 ページ: 585-588
• [雑誌論文] Phenotypic Heterogeneity within a New Family with the MAPT P301S Mutation. (2005)
  • 著者名/発表者名: Yasuda M, Nakamura Y, Kawamata T, Kaneyuki H, Maeda K, Komure O.
  • 雑誌名: Annals of Neurology 58・6 ページ: 920-928
• [雑誌論文] Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. (2004)
  • 著者名/発表者名: Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, Yamamoto T, Kosaka K, Miki T, Kondo I.
  • 雑誌名: Biochem Biophys Res Commun 321 ページ: 320-3
  • 査読あり
• [雑誌論文] C677T polymorphism of methylenetetrahydrofolate reductase gene affects plasma homocysteine level and is a genetic factor of late-onset Alzheimer's disease. (2004)
  • 著者名/発表者名: Kida T, Kamino K, Yamamoto M, Kanayama D, Tanaka T, kudo T, Takeda M.
  • 雑誌名: PSYCHOGERIATRICS 4 ページ: 4-10
  • NAID: 10018089157
  • 査読あり
• [雑誌論文] TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction. (2004)
  • 著者名/発表者名: Akatsu H, Yamagata H, Chen Y, Miki T, Kamino K, Takeda M, Campbell W, Kondo I, Kosaka K, Yamamoto T, Okada H.
  • 雑誌名: British J Haematology 127 ページ: 440-447
  • 査読あり
• [雑誌論文] Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease. (2004)
  • 著者名/発表者名: Marui W, Iseki E, Kato M, Akatsu H, Kosaka K.
  • 雑誌名: Acta Neuropathol. 108(2) ページ: 121-8
  • 査読あり
• [雑誌論文] Increased incidence of dementia with Lewy bodies in patients carrying the e4-allele of apolipoprotein E. (2004)
  • 著者名/発表者名: Akatsu H, Kamino K, Yamagata H, Isojima D, Kondo I, Yamamoto T, Kida T, Takeda M, Miki T, Kosaka K.
  • 雑誌名: PSYCHOGERIATRICS 4 ページ: 23-32
  • 査読あり
• [雑誌論文] Dynamin 2 gene is a novel susceptibility gene, for late-onset Alzheimer disease 4 carriersnin non-APOE- 4 carriers
  • 著者名/発表者名: Nuripa, Jenishbekovna Aidaralieva・Mouzin, Kamino・Ryo, Kimura・Mitsuko, Yamamoto・Takeshi, Morihara・Hiroaki, Kazui・Ryota, Hashimoto・Toshihisa, Tanaka・Takashi, Kudo・Tomoyuki, Kida, et. al.
  • 雑誌名: Journal of Human Gnentics (in press)
  • 査読あり
• [学会発表] Genetic Study on Alzheimer Disease (2009)
  • 著者名/発表者名: Rio de Janeiro
  • 学会等名: 2009 International Meeting of the International Psychogeriatric Association Symposist
  • 発表場所: Brazil
• [学会発表] Genetic Study on Alzheimer Disease Symposist (2009)
  • 著者名/発表者名: Takashi Morihara, Masatoshi Takeda
  • 学会等名: International Meeting of the International Psychogeriatric Association Symposist
  • 発表場所: Rio de Janeiro, Brazil
• [学会発表] Drastic Impact on Abeta Accumulation in APP Tg Mice By Genetic Background. (2008)
  • 著者名/発表者名: MORIHARA T, YOKOKOJI M, HAYASHI N, NOSHI E, MORI K, TAGAMI S, KUDO T, KAMINO K, TAKEDA M
  • 学会等名: ICAD 2008
  • 発表場所: Chicago USA
• [学会発表] Risk Genes for Dementia (2008)
  • 著者名/発表者名: シンポジスト
  • 学会等名: 神経化学学会2008
  • 発表場所: 富山
• [学会発表] Risk Genes for Dementia (2008)
  • 著者名/発表者名: 森原剛史, 紙野晃人, 数井裕光, 林紀行, 横小路美貴子, 工藤喬, 武田雅俊
  • 学会等名: 第51回神経化学大会
  • 発表場所: 富山
• [学会発表] アルツハイマー病モデルマウス(APP Tg)のアミロイド病理は背景遺伝子で大きく変わる (2008)
  • 著者名/発表者名: 横小路美貴子、森原剛史、林紀行、田上真次、武田雅俊
  • 学会等名: 第51回神経化学大会
  • 発表場所: 富山
• [学会発表] Drastic Impact on Abeta Accumulation in APP Tg Mice By Genetic Background (2008)
  • 著者名/発表者名: MORIHARA T, YOKOKOJI M, HAYASHIN, NOSHIE, MORI K, TAGAMI S, KUDO T, KAMINO K, TAKEDA M
  • 学会等名: ICAD 2008
  • 発表場所: Chicago USA
• [学会発表] APP TgマウスのAβ蓄積量はマウス背景遺伝子の違いで大きく変わる (2008)
  • 著者名/発表者名: 森原剛史、横小路美貴子、林紀行、田上真次、工藤喬、熨斗英理子、伊藤尚弘、西富晃平、武田雅俊
  • 学会等名: 日本認知症学会2008
  • 発表場所: 前橋
• [図書] パーキンソン病 -痴呆の問題- (2005)
  • 著者名/発表者名: 中島健二, 楠見公義, 湧谷陽介
  • 総ページ数: 9
  • 出版者: 中外医学社