競合的シナプス回路成熟の構造基盤と分子基盤

• 研究課題/領域番号: 17023001
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 北海道大学
• 研究代表者: 渡辺 雅彦 北海道大学, 大学院・医学研究科, 教授 (70210945)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 106,900千円 (直接経費: 106,900千円); 2009年度: 21,200千円 (直接経費: 21,200千円); 2008年度: 19,100千円 (直接経費: 19,100千円); 2007年度: 18,900千円 (直接経費: 18,900千円); 2006年度: 23,000千円 (直接経費: 23,000千円); 2005年度: 24,700千円 (直接経費: 24,700千円)
• キーワード: 小脳 / シナプス / グルタミン酸 / 発達 / 遺伝子改変動物 / グルタミン酸トランスポーター / 登上線維 / mGluR1 / プルキンエ細胞 / グルタミン酸受容体 / セレベリン / GluRd2 / シナプス形成 / 遺伝子ノックアウトマウス

研究概要

ニューロンには莫大な数の同種および異種線維が入力し、それぞれが競合して機能的な神経回路が確立する。本研究では運動を制御する小脳の神経回路発達に焦点を当てその細胞分子メカニズムの解明に取り組んだ。その結果、小脳プルキンエ細胞に発現するGluD2と顆粒細胞から放出されるCbln1が共同して平行線維シナプスの形成・維持を促進する一方、登上線維支配を制限することにより単一支配の確立と維持に関わることを実証した。

研究成果

• [雑誌論文] Endocannabinoids and CB1 receptors mediate C-fiber-dependent heterosynaptic plasticity in spinalcord. (2009)
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  • 査読あり
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  • 査読あり
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  • 査読あり
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  • 査読あり
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  • 査読あり
• [雑誌論文] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum. (2009)
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  • 査読あり
• [雑誌論文] Cbln1 accumulates and colocalizes with Cbln3 and GluRd2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum. (2009)
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  • 雑誌名: Eur J Neurosci 30 ページ: 1509-1516
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• [雑誌論文] Endocannabinoids and CB1 receptors mediate C-fiber-dependent heterosynaptic plasticity in spinalcord (2009)
  • 著者名/発表者名: Pernia-Andrade AJ, et al.
  • 雑誌名: Science 325 ページ: 760-764
  • 査読あり
• [雑誌論文] NMDA receptor GluN2B(GluRe2/NR2B)subunit Is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses (2009)
  • 著者名/発表者名: Akashi K, et al.
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  • 査読あり
• [雑誌論文] Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord (2009)
  • 著者名/発表者名: Yasaka T, et al.
  • 雑誌名: J.Neurosci 29 ページ: 13401-13409
  • 査読あり
• [雑誌論文] Lentiviral-vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice (2009)
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  • 雑誌名: Eur J Phramacol 615 ページ: 76-82
  • 査読あり
• [雑誌論文] Rescue of abnormal phenotypes in d2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the d2 glutamate receptor (2009)
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  • 雑誌名: Eur J Neurosci 30 ページ: 355-365
  • 査読あり
• [雑誌論文] Phospholipase Cb4 expression identifies a novel subset of unpolar brush cells in the adult mouse cerebellum (2009)
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  • 雑誌名: Cerebellum 8 ページ: 267-276
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  • 雑誌名: J.Neurosci 29 ページ: 12896-12908
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• [雑誌論文] Functional coupling between mGluR1 and Cav3.1 T-type calcium channels underlies parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines (2009)
  • 著者名/発表者名: Hildebrand ME, et al.
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  • 査読あり
• [雑誌論文] Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum (2009)
  • 著者名/発表者名: Hashimoto K, et al.
  • 雑誌名: Neuron 63 ページ: 106-118
  • 査読あり
• [雑誌論文] Kinase-dead knock-in mouse revealed an essential role of CaMKll a kinase activity in dendritic spine enlargement, LTP and learning (2009)
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• [雑誌論文] Metabotropic glutamate type 5, dopamine D2 and adenosine A2A receptors form higher-order oligomers in living cells (2009)
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• [雑誌論文] Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia (2009)
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• [雑誌論文] CB1 receptor activation and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain (2009)
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• [雑誌論文] The N-terminal domain of GluRd2 recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo (2009)
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  • 査読あり
• [雑誌論文] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • 著者名/発表者名: Fukushima, F., et al.
  • 雑誌名: ProS ONE 4
  • 査読あり
• [雑誌論文] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum (2009)
  • 著者名/発表者名: Matsuda K, et al.
  • 雑誌名: Eur J Neurosci 29 ページ: 707-717
  • 査読あり
• [雑誌論文] PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex (2009)
  • 著者名/発表者名: Zhang J, et al.
  • 雑誌名: J.Neurosci 29 ページ: 2948-2960
  • 査読あり
• [雑誌論文] Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits (2009)
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  • 雑誌名: Eur J Neurosci 29 ページ: 718-726
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• [雑誌論文] Cbln1 accumulates and colocalizes with Cbln3 and GluRd2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum (2009)
  • 著者名/発表者名: Miura E, et al.
  • 雑誌名: Eur J Neurosci 29 ページ: 693-706
  • 査読あり
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• [雑誌論文] The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence (2009)
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  • 雑誌名: Endocrinology 50 ページ: 98-103
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  • 査読あり
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  • 査読あり
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  • 著者名/発表者名: Deli L, Wittmann G, Kallo I, Lechan RM, Watanabe M, Liposits Z, Fekete C
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  • 査読あり
• [雑誌論文] The endocannabinoid system is modulated in response to spinal cord injury in rats (2009)
  • 著者名/発表者名: Garcia-Ovejero D, Arevalo-Martin A, Petrosino S, Docagne F, Hagen C, Bisogno T, Watanabe M, Guaza C, Di Marzo M, Molina-Holgado E
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  • 査読あり
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  • 査読あり
• [雑誌論文] The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence (2009)
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  • 査読あり
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  • 査読あり
• [雑誌論文] Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits (2009)
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  • 雑誌名: Eur J Neurosci (in press)
  • 査読あり
• [雑誌論文] PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex (2009)
  • 著者名/発表者名: Zhang J, Xu T, Hallett PJ, Watanabe M, Grant SGN, Isacson O, Yao W-D
  • 雑誌名: J. Neurosci (in press)
  • 査読あり
• [雑誌論文] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synaoses in the cerebellum (2009)
  • 著者名/発表者名: Matsuda K, Kondo T, Iijima T, Matsuda S, Watanabe M, Yuzaki M
  • 雑誌名: Eur J Neurosci (in press)
  • 査読あり
• [雑誌論文] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • 著者名/発表者名: Fukushima, F., Nakao, K., Shinoe, T., Fukaya, M., Muramatsu S, Sakimura, K., Kataoka, H., Mori, H., Watanabe, M., Manabe, T., Mishina, M
  • 雑誌名: ProS ONE 4
  • 査読あり
• [雑誌論文] The N-terminal domain of GluRδ2 recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo (2009)
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  • 査読あり
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  • 査読あり
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  • 査読あり
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• [雑誌論文] Enhanced cerebellar LTD induction and OKR adaptation in mice lacking delphilin. (2008)
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  • 雑誌名: PLoS One 3(5)(on-line journal)
  • 査読あり
• [雑誌論文] Cbln1 Regulates Rapid Formation and Maintenance of Excitatory Synapses in Mature Cerebellar Purkinje Cells in vitro and in vivo. (2008)
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  • 査読あり
• [雑誌論文] Dual coupling of T-type Ca2+ channels shapes sleep-related oscillations in thalamic dendrites. (2008)
  • 著者名/発表者名: Cueni L, Canepari M, Lujan R, Watanabe M, Bond CT, Adelman JP, Luthi A
  • 雑誌名: Nature Neurosci 11 ページ: 683-692
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  • 著者名/発表者名: Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, Yuzaki M
  • 雑誌名: Neuron 57 ページ: 730-745
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• [雑誌論文] SK2 channel plasticity contributes to LTP at Shaffer collateral-CA1 synapses. (2008)
  • 著者名/発表者名: Lin MT, Lujan R, Watanabe M, Adelman JP, Maylie J
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  • 査読あり
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• [雑誌論文] Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. (2005)
  • 著者名/発表者名: Abe, T., Matsumura, S., Katano, T., Mabuchi, T., Takagi, K., Xu, L., Yamamoto, A., Hattori, K., Yagi, T., Watanabe, M., Nakazawa, T., Yamamoto, T., Mishina, M., Nakai, Y., Ito, S.
  • 雑誌名: Eur.J.Nerosci. 22 ページ: 1445-1455
• [雑誌論文] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. (2005)
  • 著者名/発表者名: Wu, Y., Kawakami, R., Fukaya, M., Sakimura, K., Mishina, M., Watanabe M., Ito, I., Shigemoto, R.
  • 雑誌名: J.Neurosci. 25 ページ: 9213-9226
  • NAID: 120002697619
• [雑誌論文] Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains. (2005)
  • 著者名/発表者名: Fukaya, M.Yamazaki, M., Sakimura, K., Watanabe, M.
  • 雑誌名: Neurosci.Res. 53 ページ: 376-383
  • NAID: 10017131285
• [雑誌論文] Complementary roles of cholecystokinin and parvalbumin expressing GABAergic neurons in hippocampal network oscillations. (2005)
  • 著者名/発表者名: Klausberger, T., Marton, L.F., O'Neill, J., Huck, J.H.J., Dalezios, Y., Fuentealba, P., Suen, W.-Y, Papp, E., Kaneko T., Watanabe, M., JCsicsvari, J., Somogyi, P.
  • 雑誌名: J.Neurosci. 25 ページ: 9782-9793
• [雑誌論文] Clbn1 is essential for synaptic integrity and information processing in the cerebellum. (2005)
  • 著者名/発表者名: 6.Hirai, H., Pang, Z., Bao, D., Miyazaki, T., Li, L., Parris, J., Rong, Y., Watanabe, M., Yuzaki, M., Morgan, J.I.
  • 雑誌名: Nature Neurosci. 8 ページ: 1534-1541
• [雑誌論文] Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach. (2005)
  • 著者名/発表者名: Iwanaga, T., Goto, M., Watanabe, M.
  • 雑誌名: Biomed.Res. 26 ページ: 271-278
  • NAID: 130004903697
• [雑誌論文] Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission.
  • 著者名/発表者名: Yamasaki M, Matsui M, Watanabe M
  • 雑誌名: J. Neurosci (in press)
  • NAID: 120002414847
  • 査読あり
• [雑誌論文] Cbln1 is a ligand for an orphan glutamate receptor d2, a bidirectional synaptic organizer.
  • 著者名/発表者名: Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Itoh-Ishida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M
  • 雑誌名: Science (in press)
  • 査読あり
• [雑誌論文] Signaling cascade of diacylglycerol kinase BB in the pituitary intermediate lobe : dopamine D2 receptor/phospholipase CB4/diacylglycerol kinase B/protein kinase Ca.
  • 著者名/発表者名: Hozumi Y, et al.
  • 雑誌名: Histochem.Cytochem (In press)
  • 査読あり
• [雑誌論文] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRe2.
  • 著者名/発表者名: Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M., Yuzaki, M.
  • 雑誌名: J Neurosci (In press)
  • 査読あり
• [雑誌論文] IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts and localizes with PSD-95 at extitatory synapses.
  • 著者名/発表者名: Sakagami, H., Sanda, M., Fukaya, M., Miyazaki, T., Sukegawa, J., Yanagisawa, T., Suzuki, T., Fukunaga, K., Watanabe, M., Kondo, K.
  • 雑誌名: Neurosci Res (In press)
  • 査読あり
• [雑誌論文] Down-regulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.
  • 著者名/発表者名: Ludanyi, A., Erass, L., Czirjak, s., Vajda, J., Halasz, P., Watanabe, M., Palkovits, M., Magloczky, Z., Freund, TF., Katona, I.
  • 雑誌名: J Neurosci (In press)
  • 査読あり
• [雑誌論文] Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.
  • 著者名/発表者名: Nyilas, R., Dudok, B., Urban, GM., Mackie, K., Watanabe, M., Cravatt, BF., Freund, TF., Katona, I.
  • 雑誌名: J Neurosci (In press)
  • 査読あり
• [雑誌論文] SK2 channel plasticity contributes to LTP at Shaffer collateral-CA1 synapses.
  • 著者名/発表者名: Lin, MT., Lujan, R., Watanabe, M., Adelman, JP., Maylie, J.
  • 雑誌名: Nature Neurosci. (In press)
  • 査読あり
• [雑誌論文] Effects of FAK ablation on cerebellar foliation,Bergmann glia and climbing fiber territory on Purkinje cells.
  • 著者名/発表者名: Watanabe, F., Miyazaki, T., Takeuchi, T., Fukaya, M., Nomura, T., Noguchi, S., Mori, H., Sakimura, K., Watanabe, M., Mishina, M.
  • 雑誌名: Eur.J.Neurosci. (In press)
  • 査読あり
• [学会発表] Trafficking mode of AMPA-type glutamate receptors in Bergmann glia (2010)
  • 著者名/発表者名: Masahiro Fukaya
  • 学会等名: 第115回日本解剖学会総会・全国学術集会
  • 発表場所: 岩手県民会館(岩手市)
• [学会発表] グルタミン酸受容体GluD2は側方側枝による異所性支配を抑制し、登上線維単-支配の維持に関わっている (2010)
  • 著者名/発表者名: 宮崎太輔
  • 学会等名: 第115回日本解剖学会総会・全国学術集会
  • 発表場所: 岩手県民会館(岩手市)
• [学会発表] mGluR1シグナル伝達系依存的な余剰登上線維除去過程 (2010)
  • 著者名/発表者名: 山崎美和子
  • 学会等名: 第115回日本解剖学会総会・全国学術集会
  • 発表場所: 岩手県民会館(岩手市)
• [学会発表] 歯状回分子層における2-アラキドノイルグリセロール伝達様式の形態学的解析 (2010)
  • 著者名/発表者名: 内ヶ島基政
  • 学会等名: 第115回日本解剖学会総会・全国学術集会
  • 発表場所: 岩手県民会館(岩手市)
• [学会発表] マウス小脳におけるKCC2の細胞発現と細胞内局在に関する免疫組織化学的検討 (2010)
  • 著者名/発表者名: 河北一誠
  • 学会等名: 第115回日本解剖学会総会・全国学術集会
  • 発表場所: 岩手県民会館(岩手市)
• [学会発表] GLAST is essential for cytological differentiation of Bergmann glia and climbing fiber monoinnervation by suppressing ectopic innervation (2009)
  • 著者名/発表者名: 宮崎太輔, et al.
  • 学会等名: XXXVI International Congress of Physiological Science
  • 発表場所: 京都国際会議場(京都)
• [学会発表] Preferential expression of M1 mAChR in dendrites and spines of cortical principal cells and its anatomical evidence for volume transmission (2009)
  • 著者名/発表者名: 山崎美和子, et al.
  • 学会等名: XXXVI International Congress of Physiological Science
  • 発表場所: 京都国際会議場(京都)
• [学会発表] Immunohistochemical localization of molecules for 2-arachidonoylglycerol-mediated retrograde signaling in the mouse dentate gyros (2009)
  • 著者名/発表者名: 内ヶ島基政, et al.
  • 学会等名: XXXVI International Congress of Physiological Science
  • 発表場所: 京都国際会議場(京都)
• [学会発表] Cellular expression and synaptic localization of NMDA receptor GluN2B and GluN2D subunits in the mouse somatosensory cortex (2009)
  • 著者名/発表者名: 渡辺雅彦
  • 学会等名: 22th Biennial Meeting of the ISN/APSN Joint Meeting
  • 発表場所: BEXCO(Busan, Korea)
• [学会発表] Distinct cellular expression and synaptic localization of NMDA receptor GluN2B and GluN2D subunits in the mouse somatosensory cortex (2009)
  • 著者名/発表者名: 渡辺雅彦
  • 学会等名: 第32回日本神経科学大会 Neuro2009
  • 発表場所: 国際会議場(名古屋)
• [学会発表] GLAST is essential to maintain climbing fiber monoinnervation and glialsynapse enwrapping to cerebellar Purkinje cells (2009)
  • 著者名/発表者名: 宮崎太輔
  • 学会等名: 第32回日本神経科学大会 Neuro2009
  • 発表場所: 国際会議場(名古屋)
• [学会発表] Preferential localization of M1 mAChR in spines and thin dendrites of cortical principal neurons and its anatomical evidence for volume transmission (2009)
  • 著者名/発表者名: 山崎美和子
  • 学会等名: 第32回日本神経科学大会 Neuro2009
  • 発表場所: 国際会議場(名古屋)
• [学会発表] マウス歯状回における2-アラキドノイルグリセロールを介した逆行性伝達抑制機構の形態学的基盤解析 (2009)
  • 著者名/発表者名: 内ヶ島基政、山崎美和子, 渡辺雅彦
  • 学会等名: 第55回日本解剖学会 東北・北海道支部学術集会
  • 発表場所: 東北大学(仙台市)
• [学会発表] マウス小脳および海馬におけるセクレトグラニンII(SgII)の局在様式 (2009)
  • 著者名/発表者名: 宮崎太輔・渡辺雅彦
  • 学会等名: 第114回解剖学会総会・全国学術集会
  • 発表場所: 岡山理科大学
• [学会発表] M1受容体を介するコリン作動性神経の伝達様式とシナプス伝達調節機構 (2009)
  • 著者名/発表者名: 山崎美和子, 渡辺雅彦
  • 学会等名: 第114回解剖学会総会・全国学術集会
  • 発表場所: 岡山理科大学
• [学会発表] マウス歯状回における2-アラキドノイルグリセロールを介した逆行性伝達抑制機構に関与する分子の免疫組織化学的分布 (2009)
  • 著者名/発表者名: 内ヶ島基政・渡辺雅彦
  • 学会等名: 第114回解剖学会総会・全国学術集会
  • 発表場所: 岡山理科大学
• [学会発表] マウス小脳ピンスーにおける化学的シナプス伝達機構の検討 (2009)
  • 著者名/発表者名: 岩倉淳, 渡辺雅彦
  • 学会等名: 第114回解剖学会総会・全国学術集会
  • 発表場所: 岡山理科大学
• [学会発表] 成体マウス大脳皮質におけるニューロン周囲オリゴデンドロサイトの化学的特性の検討 (2009)
  • 著者名/発表者名: 高崎千尋・内ヶ島基政・渡辺雅彦
  • 学会等名: 第114回解剖学会総会・全国学術集会
  • 発表場所: 岡山理科大学
• [学会発表] マウス小脳ピンスーにおける化学的シナプス伝達機構の形態学的検討 (2008)
  • 著者名/発表者名: 岩倉淳, 渡辺雅彦
  • 学会等名: 2008年日本顕微鏡学会北海道支部会
  • 発表場所: 北海道大学
  • 年月日: 2008-12-01
• [学会発表] 登上線維プルキンエ細胞投射系による単一支配化への分子機構 (2008)
  • 著者名/発表者名: 渡辺 雅彦
  • 学会等名: 第113回日本解剖学会シンポジウム
  • 発表場所: 大分県・大分大学
  • 年月日: 2008-03-29
• [学会発表] Coordinated molecular organization of 2-arachidonoyl glycerol-mediated endocannabinoid signaling triggered by mGluR activation. (2008)
  • 著者名/発表者名: Watanabe M
  • 学会等名: 6th International Meeting on Metabotropic Glutamate Receptors
  • 発表場所: Sicily (Italy)
• [学会発表] Glutamate transporters provide a 'winner-takes-more' strategy to activity-dependent synapse refinement. (2008)
  • 著者名/発表者名: Watanabe, M
  • 学会等名: The 38th Seiriken/Soukendai International Conference (Stock and flow of functional molecules in synapses.
  • 発表場所: Okazaki (Japan)
• [学会発表] GLAST is essential for the maintenance of climbing fiber monoinnervation through preventing local ectopic innervations to neighbouring and remote Purkinje cells and promoting cytological differentiation of Bergmann glia (2008)
  • 著者名/発表者名: Miyazaki T, Yamasaki M, Kouichi Tanaka K, Watanabe M.
  • 学会等名: 6^<th> FENS Forum of Europian Neuroscience
  • 発表場所: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [学会発表] Preferential localization of muscarinic M1 receptor in spines and thin dendrites of cortical principal neurons and its anatomical evidence for volume transmission (2008)
  • 著者名/発表者名: Yamasaki M, Watanabe M.
  • 学会等名: 6^<th> FENS Forum of Europian Neuroscience
  • 発表場所: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [学会発表] Distinct cellular and subcellular expression of calcineurins in the mouse cerebellum (2008)
  • 著者名/発表者名: Miura E, Watanabe M.
  • 学会等名: 6^<th> FENS Forum of Europian Neuroscience
  • 発表場所: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [学会発表] Monoacylglycerol lipase is expressed not only in presynaptic terminals, butalso in astrocytes in the mouse forebrain (2008)
  • 著者名/発表者名: Uchigashima M, Watanabe M.
  • 学会等名: 6^<th> FENS Forum of Europian Neuroscience
  • 発表場所: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [学会発表] Glutamate transporters magnify critical period plasticity in developing somatosensory cortex (2008)
  • 著者名/発表者名: Takasaki C, Okada R, Mitani A, Fukaya M, Hujihara Y, Shirakawa T, Kouichi Tanaka K, Watanabe M.
  • 学会等名: 6^<th> FENS Forum of Europian Neuroscience
  • 発表場所: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [学会発表] マウス小脳におけるプルキンエ細胞のPKCγバンド状発現 (2008)
  • 著者名/発表者名: 江本美穂, 渡辺雅彦
  • 学会等名: Neuro 2008第31回日本神経科学大会
  • 発表場所: 東京国際フォーラム
• [学会発表] GLASTはバーグマングリアの形態分化および登上線維単一支配の維持に必要である (2008)
  • 著者名/発表者名: 宮崎太輔, 渡辺雅彦
  • 学会等名: 日本解剖学会第54回東北・北海道連合支部学術集会
  • 発表場所: 市民プラザ・ビッグアイ(郡山市)
• [学会発表] M1アセチルコリン受容体はマウスの大脳皮質・海馬の投射ニューロンに豊富に発現している (2008)
  • 著者名/発表者名: 山崎美和子, 渡辺雅彦
  • 学会等名: 日本解剖学会第54回東北・北海道連合支部学術集会
  • 発表場所: 市民プラザ・ビッグアイ(郡山市)
• [学会発表] マウス線条体における内因性カンナビノイド2-アラキドノイルグリセロールを介した逆行性伝達抑制の分子機構 (2007)
  • 著者名/発表者名: 内ヶ島基政, 渡辺雅彦
  • 学会等名: 日本顕微鏡学会北海道支部会
  • 発表場所: 札幌・コンペンションセンター
  • 年月日: 2007-12-01
• [学会発表] 神経系における内在性カンナビノイドの分子解剖学 (2007)
  • 著者名/発表者名: 渡辺 雅彦
  • 学会等名: 日本麻酔科学会北海道東北支部第55回北海道麻酔科学会
  • 発表場所: 札幌・北海道大学
  • 年月日: 2007-09-08
• [学会発表] 神経系における内在性カンナビノイドの合成・分解とその生理作用 (2007)
  • 著者名/発表者名: 渡辺 雅彦
  • 学会等名: 第28回鎮痛薬・オピオイドペプチドシンポジウム
  • 発表場所: 札幌・札幌医大
  • 年月日: 2007-09-01
• [学会発表] 小脳における登上線維-介在ニューロン間シナプス選択的に発現するNMDA受容体NR3Aサブユニットの分子解剖学的解析 (2007)
  • 著者名/発表者名: 深谷 昌弘、渡辺 雅彦
  • 学会等名: 第53回東北・北海道連合支部学術集会
  • 発表場所: 札幌・北海道医療大学
• [学会発表] バーグマングリアに発現するAMPA型グルタミン酸受容体の輸送様式 (2007)
  • 著者名/発表者名: 深谷昌弘、渡辺雅彦>
  • 学会等名: Neuro 2007 第30回日本神経科学大会
  • 発表場所: 横浜・パシフィコ横浜
• [学会発表] GLAST分子欠損マウスにおけるバーグマングリアの形態分化異常および形態学的登上線維多重支配 (2007)
  • 著者名/発表者名: 宮崎太輔, 田中光一, 渡辺雅彦
  • 学会等名: Neuro 2007 第30回日本神経科学大会
  • 発表場所: 横浜・パシフィコ横浜
• [学会発表] Mlムスカリン性アセチルコリン受容体は終脳の投射ニューロンに豊富に発現している (2007)
  • 著者名/発表者名: 山崎美和子、飯塚尭、渡辺雅彦
  • 学会等名: Neuro 2007 第30回日本神経科学大会
  • 発表場所: 横浜・パシフィコ横浜
• [学会発表] マウス終脳の特定の介在神経におけるPKC&alphaおよびPKC&gammaの細胞発現パターンの解析 (2007)
  • 著者名/発表者名: 三浦会里子, 窪田圭志, 渡辺雅彦
  • 学会等名: Neuro 2007 第30回日本神経科学大会
  • 発表場所: 横浜・パシフィコ横浜
• [学会発表] 線条体における2-アラキドノイルグリセロールを介した逆行性シグナル伝達に関与する分子の細胞内配置 (2007)
  • 著者名/発表者名: 内ヶ島基政, 鳴島円, 深谷昌弘, Istvan Katona, 狩野方伸, 渡辺雅彦
  • 学会等名: Neuro 2007 第30回日本神経科学大会
  • 発表場所: 横浜・パシフィコ横浜
• [学会発表] Subcellular arrangement of molecules 2-arachidonlyl-glycerol-mediated retrograde signaling in the striatum. (2007)
  • 著者名/発表者名: Motokazu, Uchigashima., Madoka, Narushima., Masahiro, Fukaya., Istvan, Katona., Masanobu, Kano., Masahiko, Watanabe.
  • 学会等名: IBRO World Congress of Neuroscience
  • 発表場所: Melbourne, Australia
• [学会発表] Selective localization of NR3A subunit at climbing fiber-interneuron synapses in the cerebellum. (2007)
  • 著者名/発表者名: Masahiro, Fukaya., Masahiko, Watanabe.
  • 学会等名: Neuroscience 2007
  • 発表場所: San Diego, California.USA
• [図書] みる見るわかる脳・神経科学入門講座改訂版 (2008)
  • 著者名/発表者名: 渡辺雅彦
  • 出版者: 羊土社
• [図書] 脳神経外科学大系1。神経科学, (山浦晶総編集) (2006)
  • 著者名/発表者名: 渡辺雅彦
  • 出版者: 中山書店
• [図書] 組織細胞化学2005, (日本組織細胞化学会編) (2005)
  • 著者名/発表者名: 渡辺雅彦
  • 出版者: 学際企画
• [備考]
  • URL: http://www.med.hokudai.ac.jp/~anat-2w/