純系ゲノム背景における脳システム制御の分子解析

• 研究課題/領域番号: 17024011
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京大学
• 研究代表者: 三品 昌美 東京大学, 大学院・医学系研究科, 教授 (80144351)
• 研究分担者: 植村 健 東京大学, 大学院・医学系研究科, 助教 (00372368) ; 竹内 倫徳 東京大学, 大学院・医学系研究科, 助教 (50323613)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 342,600千円 (直接経費: 342,600千円); 2009年度: 61,600千円 (直接経費: 61,600千円); 2008年度: 73,000千円 (直接経費: 73,000千円); 2007年度: 73,400千円 (直接経費: 73,400千円); 2006年度: 58,200千円 (直接経費: 58,200千円); 2005年度: 76,400千円 (直接経費: 76,400千円)
• キーワード: 記憶 / 学習 / 情動 / 海馬 / 線条体 / 小脳 / 標的遺伝子組換え / 誘導型Cre組換え酵素 / 情動記憶 / 音刺激恐怖条件付け学習 / 長期記憶 / マウス / NMDA受容体 / medium spiny neuron / 運動学習 / シナプス可塑性 / グルタミン酸受容体 / PDZ蛋白質 / ノックアウトマウス / ネットワーク形成 / シナプス形成 / 神経回路網形成 / PDZ蛋白 / 運動失調 / 海馬CA3領域 / 反回性回路 / 脳領域特異的遺伝子ノックアウト / EEG spike / multiple unit activity / 同期発火 / グルタミン酸受容体GluRδ2 / 誘導型CrePRリコンビナーゼ / 小脳プルキニエ細胞 / シナプス結合 / 平行線維-プルキニエ細胞シナプス / アクティブゾーン / PSD

研究概要

純系C57BL/6マウスの遺伝背景の下で、海馬、線条体あるいは小脳特異的にCreまたは誘導型Cre組換え酵素を発現するマウス系統を樹立し、脳部位特異的に遺伝子操作を行うことが可能となった。さらに、情動記憶形成に線条体が関与するなど学習のシステム制御に関する新知見が得られた。また、特定のシナプス部位でのみシナプス可塑性を亢進させるアプローチにより記憶・学習を制御する神経ネットワークの働きを解明した。

研究成果

• [雑誌論文] Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum (2010)
  • 著者名/発表者名: Uemura, T., Lee, S., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M., Taguchi, R., Sakimura, K., Mishina, M.
  • 雑誌名: Cell (in press)
  • 査読あり
• [雑誌論文] Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability (2010)
  • 著者名/発表者名: Mozhui, K., Karlsson, R-M., Kash, T., Ihne, J., Norcross, M., Patel, S., Farrell, M., Hill, E., Martin, K., Camp, M., Fitzgerald, P., Ciobanu, D., Sprengel, R., Mishina, M., Wellman, C., Winder, D., Williams, R.W., Holmes, A.
  • 雑誌名: J. Neurosci. 30 ページ: 5357-5367
  • 査読あり
• [雑誌論文] Estrogen regulates the expression of N-methyl-D-aspartate (NMDA) receptor subunit epsilon 4 (Grin2d), that is essential for the normal sexual behavior in female mice (2010)
  • 著者名/発表者名: Ikeda, K., Fukushima, T., Ogura, H., Tsukui, T., Mishina, M., Muramatsu, M., Inoue, S.
  • 雑誌名: FEBS Lett 584 ページ: 806-810
  • 査読あり
• [雑誌論文] Estrogen regulates the expression of N-methyl-D-aspartate(NMDA)receptor subunit epsilon 4(Grin2d), that is essential for the normal sexual behavior in female mice (2010)
  • 著者名/発表者名: Ikeda, K., Fukushima, T., Ogura, H., Tsukui, T., Mishina, M., Muramatsu, M., Inoue, S.
  • 雑誌名: FEBS Lett. 584 ページ: 806-810
  • 査読あり
• [雑誌論文] Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability (2010)
  • 著者名/発表者名: Mozhui, K., Karlsson, R-M., Kash, T., Ihne, J., Norcross, M., Patel, S., Farrell, M., Hill, E., Martin, K., Camp, M., Fitzgerald, P., Ciobanu, D., Sprengel, R., Mishina, M., Wellman, C., Winder, D., Williams, R.W., Holmes, A.
  • 雑誌名: J.Neurosci. (印刷中(掲載確定))
  • 査読あり
• [雑誌論文] Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum (2010)
  • 著者名/発表者名: Uemura, T., Lee, S., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M., Taguchi, R., Sakimura, K., Mishina, M.
  • 雑誌名: Cell (印刷中(掲載確定))
  • 査読あり
• [雑誌論文] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses: Lessons from GluRδ2 knockout mice (2009)
  • 著者名/発表者名: Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M., Kano, M.
  • 雑誌名: Neuroscience 162 ページ: 601-611
  • 査読あり
• [雑誌論文] NR2A at CA1 synapses is obligatory for the susceptibility of hippocampal plasticity to sleep loss (2009)
  • 著者名/発表者名: Longordo, F., Kopp, C., Mishina, M., Lujan, R., Luthi, A.
  • 雑誌名: J. Neurosci. 29 ページ: 9026-9041
  • 査読あり
• [雑誌論文] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • 著者名/発表者名: Fukushima, F., Nakao, K., Shinoe, T., Fukaya, M., Muramatsu, S., Sakimura, K., Kataoka, H., Mori, H., Watanabe, M., Manabe, T., Mishina, M.
  • 雑誌名: PLoS ONE 4
  • 査読あり
• [雑誌論文] A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus (2009)
  • 著者名/発表者名: Kishioka, A., Fukushima, F., Ito, T., Kataoka, H., Mori, H., Ikeda, T., Itohara, S., Sakimura, K., Mishina, M.
  • 雑誌名: PLoS ONE 4
  • 査読あり
• [雑誌論文] NR2A at CA1 synapses is obligatory for the susceptibility of hippocampal plasticity to sleep loss (2009)
  • 著者名/発表者名: Longordo, F., Kopp, C., Mishina, M., Lujan, R., Luthi, A.
  • 雑誌名: J.Neurosci. 29 ページ: 9026-9041
  • 査読あり
• [雑誌論文] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses : Lessons from GluRδ2 knockout mice (2009)
  • 著者名/発表者名: Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M., Kano, M.
  • 雑誌名: Neuroscience 162 ページ: 601-611
  • 査読あり
• [雑誌論文] Regulation of synaptic vesicle accumulation and axon terminal remodeling during synapse formation by distinct Ca^<2+> signaling (2009)
  • 著者名/発表者名: Yoshida, T., Uchida, S., Mishina, M.
  • 雑誌名: J.Neurochem. 111 ページ: 160-170
  • 査読あり
• [雑誌論文] A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus (2009)
  • 著者名/発表者名: Kishioka, A., Fukushima, F., Ito, T., Kataoka, H., Mori, H., Ikeda, T., Itohara, S., Sakimura, K., and Mishina, M.
  • 雑誌名: PLoS ONE 4
  • 査読あり
• [雑誌論文] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • 著者名/発表者名: Fukushima, F., Nakao, K., Shinoe, T., Fukaya, M., Muramatsu, S., Sakimura, K., Kataoka, H., Mori, H., Watanabe, M., Manabe, T., and Mishina, M.
  • 雑誌名: PLoS ONE 4
  • 査読あり
• [雑誌論文] Influence of parallel fiber-purkinje cell synapse formation on postnatal development of climbing fiber-purkinje cell synapses in the cerebellum (2009)
  • 著者名/発表者名: Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M., and Kano, M.
  • 雑誌名: Neuroscience (in pess)(掲載確定)(印刷中)
  • 査読あり
• [雑誌論文] The amino-terminal domain of glutamate receptorδ2 triggers presynaptic differentiation (2008)
  • 著者名/発表者名: Uemura, T., Mishina, M.
  • 雑誌名: Biochem. Biophys. Res. Commun. 377 ページ: 1315-1319
  • 査読あり
• [雑誌論文] Role of major NMDAR or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication (2008)
  • 著者名/発表者名: Palachick, B., Chen, Y. -C., Enoch, A.J., Karlsson, R. -M., Mishina, M., Holmes, A.
  • 雑誌名: Alcohol. Clin. Exp. Res. 32 ページ: 1479-1492
  • 査読あり
• [雑誌論文] Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking Delphilin (2008)
  • 著者名/発表者名: Takeuchi, T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T., Yamashita, M., Yamazaki, Y., Mori, H., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T., Mishina, M.
  • 雑誌名: PLoS ONE 3
  • 査読あり
• [雑誌論文] Role of the internal Shank-binding segment of glutamate receptorδ2 in synaptic localization and cerebellar functions (2008)
  • 著者名/発表者名: Yasumura, M., Uemura, T., Yamasaki, M., Sakimura, K., Watanabe, M., Mishina, M.
  • 雑誌名: Neurosci. Lett. 433 ページ: 146-151
  • 査読あり
• [雑誌論文] Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells (2008)
  • 著者名/発表者名: Watanabe, F., Miyazaki, T., Takeuchi, T., Fukaya, M., Nomura, T., Noguchi, S., Mori, H., Sakimura, K., Watanabe, M., Mishina, M.
  • 雑誌名: Eur. J. Neurosci. 27 ページ: 836-854
  • 査読あり
• [雑誌論文] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2. (2008)
  • 著者名/発表者名: Kakegawa, W., Miyzaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M., Yuzaki, M.
  • 雑誌名: J. Neurosci. 28 ページ: 1460-1468
  • 査読あり
• [雑誌論文] Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. (2008)
  • 著者名/発表者名: Brigman, J.L., Feyder, M., Saksida, L.M., Bussey, T.J., Mishina, M., Holmes, A.
  • 雑誌名: Learn. Mem. 15 ページ: 50-54
  • 査読あり
• [雑誌論文] Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking Delphilin (2008)
  • 著者名/発表者名: Takeuchi, T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T., Yamashita, M., Yamazaki, Y., Mori, H., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T. and Mishina, M.
  • 雑誌名: PLoS ONE 3
  • 査読あり
• [雑誌論文] Role of major NMDAR or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication (2008)
  • 著者名/発表者名: Palachick, B., Chen, Y.-C., Enoch, A. J., Karlsson, R.-M., Mishina, M. and Holmes, A.
  • 雑誌名: Alcoholism : Clinical and Experimental Research 32 ページ: 1479-1492
  • 査読あり
• [雑誌論文] The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation (2008)
  • 著者名/発表者名: Uemura, T., and Mishina, M.
  • 雑誌名: Biochem. Biophys. Res. Commun. 377 ページ: 1315-1319
  • 査読あり
• [雑誌論文] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2. (2008)
  • 著者名/発表者名: Kakegawa, W., et. al.
  • 雑誌名: J. Neurosci. 28 ページ: 1460-1468
  • 査読あり
• [雑誌論文] Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells. (2008)
  • 著者名/発表者名: Watanabe, F., et. al.
  • 雑誌名: Eur. J. Neurosci. 27 ページ: 836-854
  • 査読あり
• [雑誌論文] Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. (2008)
  • 著者名/発表者名: Brigman, J., et. al.
  • 雑誌名: Learn. Mem. 15 ページ: 50-54
  • 査読あり
• [雑誌論文] Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions. (2008)
  • 著者名/発表者名: Yasumura, M., et. al.
  • 雑誌名: Neurosci. Lett. 433 ページ: 146-151
  • 査読あり
• [雑誌論文] Regulation of long-term depression and climbing fiber territory by glutamate receptorδ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells (2007)
  • 著者名/発表者名: Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M., Mishina, M.
  • 雑誌名: J. Neurosci. 27 ページ: 12096-12108
  • 査読あり
• [雑誌論文] Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage (2007)
  • 著者名/発表者名: Tian, L., Stefanidakis, M., Ning, L., Lint, P.V., Nyman-Huttunen, H., Libert, C., Itohara, S., Mishina, M., Rauvala, H., Gahmberg, C.G.
  • 雑誌名: J. Cell Biol. 178 ページ: 687-700
  • 査読あり
• [雑誌論文] Nitric oxide (NO) serves as a retrograde messenger to activated neuronal NO synthase in the spinal cord via NMDA receptors (2007)
  • 著者名/発表者名: Xu, L., Mabuchi, T., Katano, T., Matsumura, S., Okuda-Ashitaka, E., Sakimura, K., Mishina, M., Ito, S.
  • 雑誌名: Nitric Oxide 17 ページ: 18-24
  • 査読あり
• [雑誌論文] Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIγ (2007)
  • 著者名/発表者名: Takemoto-Kimura, S., Ishihara-Ageta, N., Nonaka, M., Adachi-Morishima, A., Mano, T., Okamura, M., Fujii, H., Fuse, T., Hoshino, M., Suzuki, S., Kojima, M., Mishina, M., Okuno, H., Bito, H.
  • 雑誌名: Neuron 54 ページ: 755-770
  • 査読あり
• [雑誌論文] Conditional gene targeting on the pure C57BL/6 genetic background (2007)
  • 著者名/発表者名: Mishina, M., Sakimura, K.
  • 雑誌名: Neurosci. Res. 58 ページ: 105-112
  • 査読あり
• [雑誌論文] Mouse liaison for integrative brain research (2007)
  • 著者名/発表者名: Aiba, A., Inokuchi, K., Ishida, Y., Itohara, S., Kobayashi, K., Masu, M., Mishina, M., Miyakawa, T., Mori, H., Nakao, K., Obata, Y., Sakimura, K., Shirosihi, T., Wada, K., Yagi, T.
  • 雑誌名: Neurosci. Res. 58 ページ: 103-104
  • 査読あり
• [雑誌論文] Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus (2007)
  • 著者名/発表者名: Hasegawa, S., Yamaguchi, M., Nagao, H., Mishina, M., Mori, K.
  • 雑誌名: J. Neuroimmunol. 186 ページ: 75-85
  • 査読あり
• [雑誌論文] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ (2007)
  • 著者名/発表者名: Xu, L., Okuda-Ashitaka, E., Matsumura, S., Mabuchi, T., Okamoto, S., Sakimura, K., Mishina, M., Ito, S.
  • 雑誌名: Neuropharmacology 52 ページ: 1318-1325
  • 査読あり
• [雑誌論文] Ca2+ permeability of the channel pore is not essential for theδ2 glutamate receptor channel to regulate synaptic plasticity and motor coordination (2007)
  • 著者名/発表者名: Kakegawa, W., Miyazaki, T., Hirai, H., Motohashi, J., Mishina, M., Watanabe, M., Yuzaki, M.
  • 雑誌名: J. Physiol. 579 ページ: 729-735
  • 査読あり
• [雑誌論文] Ca^<2+>permeability of the channel pore is not essential for the δ2 glutamate receptor channel to regulate synaptic plasticity and motor coordination. (2007)
  • 著者名/発表者名: Kakegawa, W., et. al.
  • 雑誌名: J. Physiol. 579 ページ: 729-735
  • 査読あり
• [雑誌論文] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ. (2007)
  • 著者名/発表者名: Xu, L., et. al.
  • 雑誌名: Neuropharmacology 52 ページ: 1318-1325
  • 査読あり
• [雑誌論文] Mouse liaison for integrative brain research. (2007)
  • 著者名/発表者名: Aiba, A., et. al.
  • 雑誌名: Neurosci. Res. 58 ページ: 103-104
• [雑誌論文] Conditional gene targeting on the pure C57BL/6 genetic background. (2007)
  • 著者名/発表者名: Mishina, M. and Sakimura, K.
  • 雑誌名: Neurosci. Res. 58 ページ: 105-112
  • 査読あり
• [雑誌論文] Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. (2007)
  • 著者名/発表者名: Hasegawa, S., et. al.
  • 雑誌名: J. Neuroimmunol. 186 ページ: 75-85
  • 査読あり
• [雑誌論文] Regulation of dendritogenesis via a lipid raft-associated Ca^<2+>/calmodulin-dependent protein kinase CLICK-III/CaMKIy. (2007)
  • 著者名/発表者名: Takemoto-Kimura, S., et. al.
  • 雑誌名: Neuron 54 ページ: 755-770
  • 査読あり
• [雑誌論文] Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors. (2007)
  • 著者名/発表者名: Xu, L., et. al.
  • 雑誌名: Nitric Oxide 17 ページ: 18-24
  • 査読あり
• [雑誌論文] Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. (2007)
  • 著者名/発表者名: Tian, L., et. al.
  • 雑誌名: J. Cell Biol. 178 ページ: 687-700
  • 査読あり
• [雑誌論文] Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells. (2007)
  • 著者名/発表者名: Uemura, T., et. al.
  • 雑誌名: J. Neurosci. 27 ページ: 12096-12108
  • 査読あり
• [雑誌論文] Ca^<2+> permeability of the channel pore is not essential for the δ2 glutamate receptor channel to regulate synaptic plasticity and motor coordination. (2007)
  • 著者名/発表者名: Kakegawa, W., Miyzaki, T., Hirai H., Motohashi, J., Mishina, M., Watanabe, M., Yuzaki, M.
  • 雑誌名: J. Physiol. 579 ページ: 729-735
• [雑誌論文] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ. (2007)
  • 著者名/発表者名: Xu, L., Okuda-Ashitaka, E., Matsumura, S., Mabuchi, T., Okamoto S., Sakimura, k., Mishina, M., Ito, S.
  • 雑誌名: Neuropharmacology. 52 ページ: 1318-1325
• [雑誌論文] Mouse liaison for integrative brain research. (2007)
  • 著者名/発表者名: Aiba, A., Inokuchi, K., Ishida, Y., Itohara, S., Kobayashi, K., Masu, M., Mishina, M., Miyakawa, T., Mori, H., Nakao, k., Obata Y., Sakimura, K., Shiroishi, T., Wada, k., Yagi, T.
  • 雑誌名: Neurosci Res. 58(in press)
• [雑誌論文] Conditional gene targeting on the pure C57BL/6 genetic background. (2007)
  • 著者名/発表者名: Mishina, M., Sakimura, K.
  • 雑誌名: Neurosci. Res. 58(in press)
• [雑誌論文] Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors (2006)
  • 著者名/発表者名: Kitamura, T., Mishina, M., Sugiyama, H.
  • 雑誌名: Neurosci. Lett. 393 ページ: 94-96
  • 査読あり
• [雑誌論文] Telencephalin slows spine maturation (2006)
  • 著者名/発表者名: Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., Yoshihara, Y.
  • 雑誌名: J. Neurosci. 26 ページ: 1776-1786
  • 査読あり
• [雑誌論文] Telencephalin slows spine maturation. (2006)
  • 著者名/発表者名: Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., Yoshihara, Y.
  • 雑誌名: J. Neurosci. 26 ページ: 1776-1786
• [雑誌論文] Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors. (2006)
  • 著者名/発表者名: Kitamura, T., Mishina, M., Sugiyama, H
  • 雑誌名: Neurosci. Lett. 393 ページ: 94-96
• [雑誌論文] Telencephalin slows spine maturation. (2006)
  • 著者名/発表者名: Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., Yoshihara, Y.
  • 雑誌名: J.Neurosci. 26 ページ: 1776-1786
• [雑誌論文] Characterization of hippocampal theta rhythm in wild-type mice and glutamate receptor subunitδ2 mutant mice during eyeblink conditioning with a short trace interval (2005)
  • 著者名/発表者名: Takatsuki, K., Kawahara, S., Mishina, M., Kirino, Y.
  • 雑誌名: Brain Res. 1063 ページ: 159-167
  • 査読あり
• [雑誌論文] N-methyl-D-aspartate receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunitδ2 mutant mice (2005)
  • 著者名/発表者名: Kato, Y., Takatsuki, K., Kawahara, S., Fukunaga, S., Mori, H., Mishina, M., Kirino, Y.
  • 雑誌名: Neuroscience 135 ページ: 1017-1023
  • 査読あり
• [雑誌論文] Identification and characterization of a novel Delphilin variant with an alternative N-terminus (2005)
  • 著者名/発表者名: Yamashita, T., Miyagi, Y., Ono, M., Ito, H., Watanabe, K., Sonoda, T., Tsuzuki, K., Ozawa, S., Aoki, I., Okuda, K., Mishina, M., Kawamoto, S.
  • 雑誌名: Mol. Brain Res. 141 ページ: 83-95
  • 査読あり
• [雑誌論文] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses inε1/NR2A knockout mice (2005)
  • 著者名/発表者名: Wu, Y., Kawakami, R., Fukaya, M., Sakimura, K., Mishina, M., Watanabe, M., Ito, I., Shigemoto, R.
  • 雑誌名: J. Neurosci. 25 ページ: 9213-9226
  • 査読あり
• [雑誌論文] Fyn-kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr 1472 is essential for maintenance of neuropathic pain (2005)
  • 著者名/発表者名: Abe, T., Matsumura, S., Katano, T., Mabuchi, T., Takagi, K., Xu, L., Yamamoto, A., Hattori, K., Yagi, T., Watanabe, M., Nakazawa, T., Yamamoto, T., Sasaki, Y., Suzuki, M., Mishina, M., Nakai Y., Ito, S.
  • 雑誌名: Eur. J. Neurosci. 22 ページ: 1445-1454
  • 査読あり
• [雑誌論文] Activation of NR2A-containing NMDA receptors is not obligatory for NMDA-receptor dependent long-term potentiation (2005)
  • 著者名/発表者名: Weitlauf, C., Honse, Y., Auberson, Y.P., Mishina, M., Lovinger, D.M., Winder, D.G.
  • 雑誌名: J. Neurosci. 25 ページ: 8386-8390
  • 査読あり
• [雑誌論文] Effect of N-methyl-D-aspartate receptorε1 subunit gene disruption of the action of general anesthetic drugs in mice (2005)
  • 著者名/発表者名: Sato, Y., Kobayashi, E., Murayama, T., Mishina, M., Seo, N.
  • 雑誌名: Anesthesiology 102 ページ: 557-561
  • 査読あり
• [雑誌論文] Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptorδ2 subunit or Purkinje cells (2005)
  • 著者名/発表者名: Katoh, A., Yoshida, T., Himeshima, Y., Mishina, M., Hirano, T.
  • 雑誌名: Eur. J. Neurosci. 21 ページ: 1315-1326
  • 査読あり
• [雑誌論文] Role of hippocampal NMDA receptors in trace eyeblink conditioning (2005)
  • 著者名/発表者名: Sakamoto, T., Takatsuki, K., Kawahara, S., Kirino, Y., Niki, H., Mishina, M.
  • 雑誌名: Brain Res. 1039 ページ: 130-136
  • 査読あり
• [雑誌論文] Control of synaptic connection by glutamate receptorδ2 in the adult cerebellum (2005)
  • 著者名/発表者名: Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • 雑誌名: J. Neurosci. 25 ページ: 2146-2156
  • 査読あり
• [雑誌論文] Rescue of abnormal phenotypes of theδ2 glutamate receptor-null mice by mutantδ2 transgenes (2005)
  • 著者名/発表者名: Hirai, H., Miyazaki, T., Kakegawa, W., Matsuda, S., Mishina, M., Watanabe, M., Yuzaki, M.
  • 雑誌名: EMBO Reports 6 ページ: 90-95
  • 査読あり
• [雑誌論文] Rescue of abnormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes. (2005)
  • 著者名/発表者名: Hirai, H., Miyazaki, T., Kakegawa, W., Matsuda S., Mishina, M., Watanabe, M., Yuzaki, M.
  • 雑誌名: EMBO Report 6 ページ: 90-95
• [雑誌論文] Control of synaptic connection by glutamate receptor δ2 in the adult cerebellum. (2005)
  • 著者名/発表者名: Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • 雑誌名: J.Neurosci. 25 ページ: 2146-2156
• [雑誌論文] Distinct roles of calcineurin-nuc lear factor o activated T-cells and protein kinase A-cAMP response element binding protein signaling in presynaptic differentiation. (2005)
  • 著者名/発表者名: Yoshida, T., Mishina, M.
  • 雑誌名: J.Neurosci. 25 ページ: 3067-3079
• [雑誌論文] Role of hippocampal NMDA receptors in trace eyeblink conditioning. (2005)
  • 著者名/発表者名: Sakamoto, T., Takatsuki, K., Kawahara, S., Kirino, Y., Niki, H., Mishina, M.
  • 雑誌名: Brain Res. 1039 ページ: 130-136
• [雑誌論文] Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor δ2 subunit or Purkinje cells. (2005)
  • 著者名/発表者名: Katoh, A., Yoshida, T., Himeshima, Y., Mishina, M., Hirano, T.
  • 雑誌名: Eur.J.Neurosci. 21 ページ: 1315-1326
• [雑誌論文] Effect of N-methyl-D-aspartate receptor ε1 subunit gene disruption of the action of general anesthetic drugs in mice. (2005)
  • 著者名/発表者名: Sato, Y., Kobayashi, E., Murayama, T., Mishina, M., Seo, N.
  • 雑誌名: Anesthesiology 102 ページ: 557-561
• [雑誌論文] Autoantibodies and cell-mediated autoimmunity to NMDA-type GluRε2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua. (2005)
  • 著者名/発表者名: Takahashi, Y., Mori, H., Mishina, M., Watanabe, M., Kondo, N., Shimomura, J., Kubota, Y., Matsuda, K., Fukushima, K., Shiroma, N., Akasaka, N., Nishida, H., Imamura A., Watanabe, H., Sugiyama, N., Ikezawa, M., Fujiwara, T.
  • 雑誌名: Epilepsia 46(Suppl.5) ページ: 152-158
• [雑誌論文] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • 著者名/発表者名: Taniguchi, M., Masuda T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma H., Watanabe, M., Shimizu, T.
  • 雑誌名: Genes Cells 10 ページ: 785-792
• [雑誌論文] Activation of NR2A-containing NMDA receptors is not obligatory for NMDA-receptor dependent long-term potentiation. (2005)
  • 著者名/発表者名: Weitlauf, C., Honse, Y., Auberson, Y.P., Mishina, M., Lovinger, D.M., Winder, D.G.
  • 雑誌名: J.Neurosci. 25 ページ: 8386-8390
• [雑誌論文] Fyn-kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr 1472 is essential for maintenance of neuropathic pain. (2005)
  • 著者名/発表者名: Abe, T., Matsumura, S., Katano, T., Mabuchi, T., Takagi, K., Xu L., Yamamoto A., Hattori, K., Yagi, T., Watanabe, M., Nakazawa, T., Yamamoto, T., Sasaki, Y., Suzuki, M., Mishina, M., Nakai Y., Ito, S.
  • 雑誌名: Eur.J.Neurosci. 22 ページ: 1445-1454
• [雑誌論文] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knockout mice. (2005)
  • 著者名/発表者名: Wu, Y., Kawakami, R., Fukaya, M., Sakimura, K., Mishina, M., Watanabe, M., Ito, I., Shigemoto, R.
  • 雑誌名: J.Neurosci. 25 ページ: 9213-9226
• [雑誌論文] Identification and characterization of a novel Delphilin variant with an alternative N-terminus. (2005)
  • 著者名/発表者名: Yamashita, T., Miyagi, Y., Ono, M., Ito, H., Watanabe, K., Sonoda, T., Tsuzuki, K., Ozawa, S., Aoki, I., Okuda, K., Mishina, M., Kawamoto, S.
  • 雑誌名: Mol.Brain Res. 141 ページ: 83-95
• [雑誌論文] N-methyl-D-aspartate receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunit δ2 mutant mice. (2005)
  • 著者名/発表者名: Kato, Y., Takatsuki, K., Kawahara, S., Fukunaga, S., Mori, H., Mishina, M., Kirino, Y.
  • 雑誌名: Neuroscience 135 ページ: 1017-1023
• [雑誌論文] Characterization of hippocampal theta rhythm in wild-type mice and glutamate receptor subunit δ2 mutant mice during eyeblink conditioning with a short trace interval. (2005)
  • 著者名/発表者名: Takatsuki K., Kawahara S., Mishina, M., Kirino, Y.
  • 雑誌名: Brain Res. 1063 ページ: 159-167
• [学会発表] A study of the role of the layer 4 of the cerebral cortex in fear memory (2010)
  • 著者名/発表者名: N.Endo, T.Uemura, K.Sakimura, S.Itohara, M.Mishina
  • 学会等名: The 83^<nd> Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Osaka International Convention Center, Osaka, Japan
  • 年月日: 2010-03-18
• [学会発表] Control of synaptic connection by Cbln1 in the adult cerebellum (2010)
  • 著者名/発表者名: M.Yasumura, T.Takeuchi, T.Uemura, K.Sakimura, M.Mishina
  • 学会等名: The 83^<nd> Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Osaka International Convention Center, Osaka, Japan
  • 年月日: 2010-03-17
• [学会発表] Identification of Cbln1 as a novel ligand for glutamate receptor δ2 (2010)
  • 著者名/発表者名: T.Uemura, S-J.Lee, M.Yasumura, T.Yoshida, M.Ra, R.Taguchi, M.Mishina
  • 学会等名: The 83^<nd> Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Osaka International Convention Center, Osaka, Japan
  • 年月日: 2010-03-17
• [学会発表] High-affinity and selective binding of Cbln1 to glutamate receptor δ2 (2010)
  • 著者名/発表者名: S.J.Lee, T.Uemura, M.Mishina
  • 学会等名: The 83^<nd> Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Osaka International Convention Center, Osaka, Japan
  • 年月日: 2010-03-17
• [学会発表] Establishment of a mouse line for inducible ablation of neurons in the layer 4 of the cerebral cortex (2009)
  • 著者名/発表者名: N.Endo, T.Uemura, K.Sakimura, S.Itohara, M.Mishina
  • 学会等名: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Nagoya Congress Center, Nagoya, Japan
  • 年月日: 2009-09-18
• [学会発表] Effects of inducible ablation of cerebellar granule or Purkinje cells on motor control (2009)
  • 著者名/発表者名: E.Kato, T.Uemura, X.Chen, F.Watanabe, M.Yasumura, S.Itohara, K.Sakimura, M.Mishina
  • 学会等名: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Nagoya Congress Center, Nagoya, Japan
  • 年月日: 2009-09-18
• [学会発表] The role of the N-terminal domain of glutamate receptor δ2 in synapse formation (2009)
  • 著者名/発表者名: T.Uemura, M.Mishina
  • 学会等名: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Nagoya Congress Center, Nagoya, Japan
  • 年月日: 2009-09-17
• [学会発表] GruRε2(NR2B)is specifically involved in the corticospinal synapse elimination during development (2009)
  • 著者名/発表者名: T.Ohno, H.Maeda, N.Murabe, T.Kamiyama, N.Yoshioka, M.Mishina, M.Sakurai
  • 学会等名: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Nagoya Congress Center, Nagoya, Japan
  • 年月日: 2009-09-16
• [学会発表] Role of the C-terminal PDZ binding domain of glutamate receptor 82 in synaptic plasticity and climbing fiber wiring (2008)
  • 著者名/発表者名: T. Uemura, S. Kakizawa, M. Yamasaki, K. Sakimura, M. Watanabe, M. Iino and M. Mishina
  • 学会等名: The 31^<th> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Tokyo International Forum. Japan
  • 年月日: 2008-07-11
• [学会発表] Role of the internal Shank-binding segment of GluR82 in cerebellar functions (2008)
  • 著者名/発表者名: M. Yasumura, T. Uemura, M. Yamasaki, K. Sakimura, M. Watanabe and M. Mishina
  • 学会等名: The 31^<th> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Tokyo International Forum Japan
  • 年月日: 2008-07-11
• [学会発表] Auditory fear memory requires the striatal neurons under weak conditioning (2008)
  • 著者名/発表者名: A Kishioka, F Fukushima, T. Ito, H. Kataoka, H. Mori, T. Ikeda, S. Itohara, K. Sakimura and M. Mishina
  • 学会等名: The 31^<th> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Tokyo International Forum Japan
  • 年月日: 2008-07-10
• [学会発表] The ectopic location of Bergmann glia and altered climbing fiber territory on Purkinje cells by FAK ablation (2008)
  • 著者名/発表者名: F Watanabe, T. Miyazaki, T. Takeuchi, K. Sakimura, M. Watanabe and M. Mishina
  • 学会等名: The 31^<th> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Tokyo International Forum, Japan
  • 年月日: 2008-07-10
• [学会発表] Motor dysfunction in neostriatal vesicular GABA transporter knock out mice (2008)
  • 著者名/発表者名: K. Saito, T. Kakizaki, T. Momiyama, H. Kataoka, M. Mishina and Y. Yanaaawa
  • 学会等名: The 31^<th> Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Tokyo International Forum, Japan
  • 年月日: 2008-07-09
• [学会発表] From glutamate receptors to brain dynamics. (2008)
  • 著者名/発表者名: Mishina, M.
  • 学会等名: The 81st Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2008-03-19
• [学会発表] Auditory fear memory requires the striatal neurons under weak conditioning. (2008)
  • 著者名/発表者名: Kishioka, A., et. al.
  • 学会等名: The 81st Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2008-03-17
• [学会発表] The C-terminal domain of GluRδ2 is essential for cerebellar LTD and regulation of Climbing fiber territory at parallel fiber synapses in cerebellar Purkinje cells (2008)
  • 著者名/発表者名: Uemura, T., et. al.
  • 学会等名: The 81st Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2008-03-17
• [学会発表] Retardations in cerebellar foliation, the ectopic lacation of Bergmann glia, and altered climbing fiber territory on Pukinje cells by FAK abration. (2008)
  • 著者名/発表者名: Watanabe, F., et. al.
  • 学会等名: The 81st Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2008-03-17
• [学会発表] Viral vector-mediated ablation of the hippocampal CA3 NMDA receptors in the mature mice generated large-amplitude spike activities. (2008)
  • 著者名/発表者名: Fukushima, F., et. al.
  • 学会等名: The 81st Annual Meeting of the Japanese Pharmacological Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2008-03-17
• [学会発表] Studies on glutamate receptor functions in learning and neural wiring by region-specific and inducible ablation. (2007)
  • 著者名/発表者名: Mishina, M.
  • 学会等名: 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists / 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists
  • 発表場所: Adelaide, Australia
  • 年月日: 2007-12-03
• [学会発表] Regulation of climbing fiber territory by the carboxyl terminal of GluRδ2 at parallel fiber synapses in cerebellar Purkinje cells. (2007)
  • 著者名/発表者名: Uemura, T., et. al.
  • 学会等名: Society for Neuroscience 37th Annual Meeting
  • 発表場所: San Diego, USA
  • 年月日: 2007-11-06
• [学会発表] GluRε2[2B] dependent synapse elimination of corticospinal tract in mice. (2007)
  • 著者名/発表者名: Ohno, T., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2007-09-11
• [学会発表] Accelerated maturation of visual response properties in telencephalin knockout mice. (2007)
  • 著者名/発表者名: Fagiolini, M., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 年月日: 2007-09-11