水圏生物の核内受容体CARを利用した化学物質のハイスループットリスク評価

• 研究課題/領域番号: 17208030
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 環境農学
• 研究機関: 愛媛大学
• 研究代表者: 岩田 久人 愛媛大学, 沿岸環境科学研究センター, 教授 (10271652)
• 研究分担者: 金 恩英 愛媛大学, 沿岸環境科学研究センター, グローバルCOE准教授 (70419513) ; 田辺 信介 愛媛大学, 沿岸環境科学研究センター, 教授 (60116952)
• 研究期間 (年度): 2005 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 43,940千円 (直接経費: 33,800千円、間接経費: 10,140千円); 2008年度: 8,840千円 (直接経費: 6,800千円、間接経費: 2,040千円); 2007年度: 9,880千円 (直接経費: 7,600千円、間接経費: 2,280千円); 2006年度: 9,750千円 (直接経費: 7,500千円、間接経費: 2,250千円); 2005年度: 15,470千円 (直接経費: 11,900千円、間接経費: 3,570千円)
• キーワード: constitutive androstane receptor / PCB / DDT / POPs / アザラシ / 核内レセプター / CAR / 難分解性有機汚染物質 / 水圏生物 / シグナル伝達 / リスク評価

研究概要

バイカルアザラシの核内受容体constitutive androstane receptor(CAR)と反応する化学物質をスクリーニングしたところ、PCB やDDT はCARとよく反応することが明らかとなった。これらの結果から、過去にラットやマウスなどの齧歯類で得られたCAR に関する知見は、難分解性有機汚染物質(POPs)に対する反応差の観点から、水棲哺乳類などの野生生物に単純に外挿できないことがわかった。一方で本研究の結果は、各野生生物種のCAR遺伝子を用いて構築したin vitroアッセイ系により、対象種固有のPOPsのリスクが評価できる可能性を示した。

研究成果

• [雑誌論文] Dioxin activation of CYP1A5 promoter/enhancer regions from two avian species, common cormorant ( Phalacrocorax carbo) and chicken ( Gallus gallus) : association with aryl hydrocarbon receptor 1 and 2 isoforms (2009)
  • 著者名/発表者名: Lee, J.S., Kim, E.Y., Iwata, H.
  • 雑誌名: Toxicology and Applied Pharmacology 234 ページ: 1-13
  • 査読あり
• [雑誌論文] Alkoxyresorufin(methoxy-, ethoxy-, pentoxy- and benzyloxyresorufin)O-dealkylase activities by in vitro expressed cytochrome P450 1A4 and 1A5 from common cormorant(Phalacrocorax carbo) (2009)
  • 著者名/発表者名: Kubota, A., Kim, E. Y., Iwata, H.
  • 雑誌名: Comparative Biochemistry and Physiology. Toxicology & Pharmacology 149(4) ページ: 544-551
  • 査読あり
• [雑誌論文] Accumulation features and temporal trends of PCDDs, PCDFs and PCBs in Baikal seals(Pusa sibirica) (2009)
  • 著者名/発表者名: Imaeda, D., Iwata, H., et al.
  • 雑誌名: Environmental Pollution 157(3) ページ: 737-747
  • 査読あり
• [雑誌論文] Effects of co-exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and perfluorooctane sulfonate or perfluorooctanoic acid on expression of cytochrome P450 isoforms in chicken(Gallus gallus)embryo hepatocyte cultures (2009)
  • 著者名/発表者名: Watanabe, M. X., Iwata, H., et al.
  • 雑誌名: Comparative Biochemistry and Physiology. Toxicology & Pharmacology 149(4) ページ: 605-612
  • 査読あり
• [雑誌論文] Catalytic function of avian cytochrome P450 1A4 and 1A5 (CYP1A4 and CYP1A5) enzymes heterologously expressed using in vitro yeast system (2008)
  • 著者名/発表者名: Kubota, A., Iwata, H. and Kim, E.Y.
  • 雑誌名: Marine Environmental Research 66(1) ページ: 154-155
  • 査読あり
• [雑誌論文] Contamination and effects of perfluorochemicals in Baikal seal. 1. residue level, tissue distribution, and temporal trend (2008)
  • 著者名/発表者名: Ishibashi, H., Iwata, H., Kim, E.Y., 他7名
  • 雑誌名: Environmental Science & Technology 42 ページ: 2295-2301
  • 査読あり
• [雑誌論文] Contamination and effects of perfluorochemicals in Baikal seal. 2. molecular characterization, expression level, and transcriptional activation of peroxisome proliferator-activated receptor α (2008)
  • 著者名/発表者名: Ishibashi, H., Iwata, H., Kim, E.Y., 他5名
  • 雑誌名: Environmental Science & Technology 42 ページ: 2302-2308
  • 査読あり
• [雑誌論文] Contamination and effects of perfluorochemicals in Baikal seal (Pusa sibirica). 1. Residue level, tissue distribution, and temporal trend. (2008)
  • 著者名/発表者名: Ishibashi, H., Iwata, H., et al.
  • 雑誌名: Environmental Science and Technology 42(7) ページ: 2295-2301
  • 査読あり
• [雑誌論文] Contamination and effects of perfluorochemicals in Baikal seal (Pusa sibirica). 2. Molecular characterization, expression level, and transcriptional activation of peroxisome proliferator-activated receptor a. (2008)
  • 著者名/発表者名: Ishibashi, H., Iwata, H., et al.
  • 雑誌名: Environmental Science and Technology 42(7) ページ: 2302-2308
  • 査読あり
• [雑誌論文] Dioxin activation of CYP1A5 promoter/enhancer regions from two avian species, common cormorant(Phalacrocorax carbo)and chicken (Gallus gallus) : Association with aryl hydrocarbon receptor 1 and 2 isoforms. (2008)
  • 著者名/発表者名: Lee, J. S., Kim, E. Y., Iwata, H.
  • 雑誌名: Toxicology and Applied Pharmacology 234 ページ: 1-13
  • 査読あり
• [雑誌論文] Toxicogenomic analysis of immune system-related genes in Japanese flounder(Paralichthya olivaceus)exposed to heavy oil. (2008)
  • 著者名/発表者名: Nakayama, K., Iwata, H., et al.
  • 雑誌名: Marine Pollution Bulletin 57(6-12) ページ: 445-452
  • 査読あり
• [雑誌論文] Potential effects of perfluorinated compounds in common cormorants from Lake Biwa, Japan : an implication from the hepatic gene expression profiles by microarray. (2008)
  • 著者名/発表者名: Nakayama, K., Iwata, H., et al.
  • 雑誌名: Environmental Toxicology and Chemistry 27(1) ページ: 2378-2386
  • 査読あり
• [雑誌論文] Molecular characterization of cytochrome P450 1A1, 1A2, and 1B1, and effects of polychlorinated dibenzo- p-dioxin, dibenzofuran, and biphenyl congeners on their hepatic expression in Baikal seal (2007)
  • 著者名/発表者名: Hirakawa, S., Iwata, H., Takeshita, Y., Kim, E.Y., 他6名
  • 雑誌名: Toxicological Sciences 97 ページ: 318-335
  • 査読あり
• [雑誌論文] Functional characterization and evolutionary history of two aryl hydrocarbon receptor isoforms (AhR1 and AhR2) from Avian Species (2007)
  • 著者名/発表者名: Yasui, T., Kim, E.Y., Iwata, H., 他4名
  • 雑誌名: Toxicological Sciences 99 ページ: 101-117
  • 査読あり
• [雑誌論文] Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (2007)
  • 著者名/発表者名: Niimi, S., Kim, E.Y., Iwata, H., Watanabe, M.X., 他3名
  • 雑誌名: Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology 147(4) ページ: 667-81
  • 査読あり
• [雑誌論文] Molecular characterization and tissue distribution of aryl hydrocarbon receptor nuclear translocator isoforms, ARNT1 and ARNT2, and identification of novel splice variants in common cormorant (Phalacrocorax carbo) (2007)
  • 著者名/発表者名: Lee, J.S., Kim, E.Y., Iwata, H., Tanabe, S.
  • 雑誌名: Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 145(3) ページ: 379-93
  • 査読あり
• [雑誌論文] Chemical contamination in aquatic ecosystems (2007)
  • 著者名/発表者名: Iwata, H., Kim, E.Y., 他4名
  • 雑誌名: Yakugaku Zasshi 127(3) ページ: 417-428
  • NAID: 110006240150
  • 査読あり
• [雑誌論文] Toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in developing red seabream (Pagrus major) embryo : an association of morphological deformities with AHR1, AHR2 and CYP1A expressions (2007)
  • 著者名/発表者名: Yamauchi, M., Kim, E.Y., Iwata, H., Shima, Y. and Tanabe, S.
  • 雑誌名: Aquatic Toxicology 40 ページ: 6919-6927
  • 査読あり
• [雑誌論文] Molecular characterlzation of cytochrome P450 1A1,1A2, and 1B1,and effects of polychlorinated dibenzo-p-dioxin,dibenzofuran,and biphenyl congeners on their hepatic expression (2007)
  • 著者名/発表者名: Hirakawa, S., Iwata, H., Kim, E.Y., et. al.
  • 雑誌名: Toxicological Sciences 97(2) ページ: 318-335
  • 査読あり
• [雑誌論文] Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutrostrata) (2007)
  • 著者名/発表者名: Niimi, S., Kim, E.Y., Iwata, H., et. al.
  • 雑誌名: Comparative Biochemistry and physiology, part B 147(4) ページ: 667-681
  • 査読あり
• [雑誌論文] Functional characterization and evolutionary history of two aryl hydrocarbon receptor isoforms (AhR1 and AhR2) from avian species (2007)
  • 著者名/発表者名: Yasui, T., Kim, E.Y., Iwata, H., et. al.
  • 雑誌名: Toxicological Sciences 99(1) ページ: 101-17
  • 査読あり
• [雑誌論文] Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo) : evolutionary relationships and functional implications associated with dioxin and related compounds (2006)
  • 著者名/発表者名: Kubota, A., Iwata, H., Goldstone, H. M. H., Kim, E. Y., Stegeman, J. J. and Tanabe, S.
  • 雑誌名: Toxicological Sciences 92 ページ: 394-408
  • 査読あり
• [雑誌論文] Congener-specific toxicokinetics of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in black-eared kites : cytochrome P4501A-dependent hepatic sequestration (2006)
  • 著者名/発表者名: Kubota, A., Iwata, H., 他3名
  • 雑誌名: Environmental Toxicology and Chemistry 25 ページ: 1007-1016
  • 査読あり
• [雑誌論文] Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal : molecular characterization, expression level and ligand profiling in Baikal seal (2006)
  • 著者名/発表者名: Sakai, H., Iwata, H., Kim, E.Y., 他5名
  • 雑誌名: Toxicological Sciences 94 ページ: 57-70
  • 査読あり
• [雑誌論文] PCDDs, PCDFs, and coplanar PCBs in wild terrestrial mammals from Japan : congener specific accumulation and hepatic sequestration (2006)
  • 著者名/発表者名: Kunisue, T., Watanabe, M.X., Iwata, H., 他4名
  • 雑誌名: Environmental Pollution 140(3) ページ: 525-535
  • 査読あり
• [雑誌論文] Congener-specific toxicokinetics of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in black-eared kites (Milvus migrans) : cytochrome P4501A-dependent hepatic sequestration. (2006)
  • 著者名/発表者名: Kubota, A.
  • 雑誌名: Environmental Toxicology and Chemistry 25(4) ページ: 1007-1016
• [雑誌論文] Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal : molecular characterization, expression level and ligand profiling in Baikal seal (Pusa sibirica). (2006)
  • 著者名/発表者名: Sakai, H.
  • 雑誌名: Toxicological Sciences 94(1) ページ: 57-70
• [雑誌論文] Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in developing red seabream (Pagrus major) embryo : an association of morphological deformities with AHR1, AHR2 and CYP1A expressions. (2006)
  • 著者名/発表者名: Yamauchi, M.
  • 雑誌名: Aquatic Toxicology 80(2) ページ: 166-179
• [雑誌論文] Bioaccumulation of organochlorines in crows from Indian open waste dumping site : evidence for direct transfer of dioxin-like congeners from the contaminated soil (2005)
  • 著者名/発表者名: Watanabe, M.X., Iwata, H., 他3名
  • 雑誌名: Environmental Science and Technology 39 ページ: 4421-4430
  • 査読あり
• [雑誌論文] Hepatic CYP1A induction by dioxin-like compounds, and congener-specific metabolism and sequestration in wild common cormorants from Lake Biwa Japan. (2005)
  • 著者名/発表者名: Kubota, A., Iwata, H., Tanabe, S., Yoneda, K. and Tobata, S.
  • 雑誌名: Environmental Science and Technology 39 ページ: 3611-3619
  • 査読あり
• [雑誌論文] Induction of cytochrome P450 1A5 mRNA, protein and enzymatic activities by dioxin-like compounds, and congener-specific metabolism and sequestration in the liver of wild jungle crow from Tokyo, Japan (2005)
  • 著者名/発表者名: Watanabe, M.X., Iwata, H., Kim, E.Y., 他3名
  • 雑誌名: Toxicolgical Sciences 88 ページ: 384-399
  • 査読あり
• [雑誌論文] Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales ( Balaenoptera acutorostrata) (2005)
  • 著者名/発表者名: Niimi, S., Watanabe, M.X., Kim, E.Y., Iwata, H., Yasunaga, G., Fujise, Y. and Tanabe, S.
  • 雑誌名: Marine Pollution Bulletin 51 ページ: 784-793
  • 査読あり
• [雑誌論文] Aryl hydrocarbon receptor (AHR) and AHR nuclear translocator expression in Baikal seal and association with 2,3,7,8-TCDD toxic equivalents and CYP1 expression levels (2005)
  • 著者名/発表者名: Kim, E.Y., Iwata, H., 他5名
  • 雑誌名: Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 141 ページ: 281-291
  • 査読あり
• [雑誌論文] Molecular characterization of the aryl hydrocarbon receptors (AHR1 and AHR2) from red seabream ( Pagrus major) (2005)
  • 著者名/発表者名: Yamauchi, M., Kim, E.Y., Iwata, H. and Tanabe, S.
  • 雑誌名: Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 141 ページ: 177-187
  • 査読あり
• [雑誌論文] Induction of cytochrome P450 1A5 mRNA, protein and enzymatic activities by dioxin-like compounds, and congener-specific metabolism and sequestration in the liver of wild jungle crow (Corvus macrorhynchos) from Tokyo, Japan. (2005)
  • 著者名/発表者名: Watanabe, M.X.
  • 雑誌名: Toxicological Sciences 88(2) ページ: 384-399
• [雑誌論文] Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata) (2005)
  • 著者名/発表者名: Niimi, S.
  • 雑誌名: Marine Pollution Bulletin 51(8-12) ページ: 784-793
• [雑誌論文] Aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) expression in Baikal seal (Pusa sibirica) and association with 2,3,7,8-TCDD toxic equivalents and CYP1 expression levels (2005)
  • 著者名/発表者名: Kim, E.Y.
  • 雑誌名: Comparative Biochemistry and Physiology C 141(3) ページ: 281-291
• [雑誌論文] Bioaccumulation of organochlorines in crows from an indian open waste dumping site : evidence for direct transfer of dioxin-like congeners from the contaminated soil (2005)
  • 著者名/発表者名: Watanabe, M.X.
  • 雑誌名: Environmental Science and Technology 39(12) ページ: 4421-4430
• [雑誌論文] Molecular characterization of the aryl hydrocarbon receptors (AHR1 and AHR2) from red seabream (Pagrus major) (2005)
  • 著者名/発表者名: Yamauchi, M.
  • 雑誌名: Comparative Biochemistry and Physiology C 141(2) ページ: 177-187
• [雑誌論文] Hepatic CYP1A induction by dioxin-like compounds, and congener-specific metabolism and sequestration in wild common cormorants from Lake Biwa, Japan (2005)
  • 著者名/発表者名: Kubota, A.
  • 雑誌名: Environmental Science and Technology 39(10) ページ: 3611-3619
• [学会発表] バイカルアザラシCYP2BおよびCYP3Aプロモーター/エンハンサー領域の分子特性とPOPsによる転写活性化能 (2008)
  • 著者名/発表者名: 酒井大樹・岩田久人・金恩英・Petrov, E. A.・田辺信介
  • 学会等名: 環境ホルモン学会第11回研究発表会
  • 発表場所: 東京
  • 年月日: 2008-12-13
• [学会発表] Searching dioxin-responsive genes and mechanisms of dioxin effects in the liver of Baikal seals. Interdisciplinary Symposium on Environmental Sciences. (2008)
  • 著者名/発表者名: Hirakawa, S., Iwata, H., et al.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers
  • 発表場所: Matsuyama, Japan
  • 年月日: 2008-11-11
• [学会発表] Molecular characterization of Baikal seal CYP2B/3A promoter/enhancer regions and their transactivation potencies by POPs. (2008)
  • 著者名/発表者名: Sakai, H., Iwata, H., et al.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia
  • 年月日: 2008-08-06
• [学会発表] Effects of dioxins in wild Baikal seals : an implication from a toxicogenomic approach. (2008)
  • 著者名/発表者名: Hirakawa, S., Iwata, H., et al.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia
  • 年月日: 2008-08-06
• [学会発表] AHR-CYP1A signaling pathway in birds : inter-species and -isoform comparisons. (2008)
  • 著者名/発表者名: Kim, E. Y., Iwata, H., et al.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia
  • 年月日: 2008-08-06
• [学会発表] Effects of in ovo exposure of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on AHR-CYPIA signaling pathway in common cormorant. (2008)
  • 著者名/発表者名: Nagahama, N., Iwata, H., et al.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia
  • 年月日: 2008-08-06
• [学会発表] Molecular characterization and functional analysis of aryl hydrocarbon receptor 1 and 2 (AHR1 and AHR2) isoforms from jungle crow (Corvus macrorhynchos). (2008)
  • 著者名/発表者名: Inoue, N., Kim, E. Y., Iwata, H.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia
  • 年月日: 2008-08-06
• [学会発表] Molecular characterization of Baikal seal CYP2B/3A promoter/enhancer regions and their transactivation potencies by POPs (2008)
  • 著者名/発表者名: Sakai, H., Iwata, H., Kim, E. Y., Petrov, E. A. and Tanabe, S.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia(Abstract CD)
  • 年月日: 2008-08-04
• [学会発表] Effects of dioxins in wild Baikal seals : an implication from a toxicogenomic approach (2008)
  • 著者名/発表者名: Hirakawa, S., Imaeda, D., Nakayama, K., Kim, E. Y., Kunisue, T., Tanabe, S., Petrov, E. A., Batoev, V. B. and Iwata, H.
  • 学会等名: 5^<th> SETAC World Congress
  • 発表場所: Sydney, Australia(Abstract CD)
  • 年月日: 2008-08-04
• [学会発表] Relative Potencies of Individual Dioxin-Like Compounds for In Vitro Cytrochrome P450 1A1 Transactivation of Aryl Hydrocarbon Receptor from Baikal Seal (2008)
  • 著者名/発表者名: Iwata, H., Kim, E.Y., Suda, T., Tanabe, S. and Petrov, E.A.
  • 学会等名: Society of Toxicology 47^<th> Annual Meeting. Washington
  • 発表場所: Seattle, USA, Program
  • 年月日: 2008-03-18
• [学会発表] Low Induction Potencies of Cytochrome P450 2B and 3A by Persistent Organic Pollutants in Baikal Seal ( Pusa sibirica) (2008)
  • 著者名/発表者名: Sakai, H., Iwata, H., Kim, E.Y., Petrov, E.A. and Tanabe, S.
  • 学会等名: Biological Responses to Chemical Pollutants : Toward Establishing an Asian Network of Environmental Toxicology
  • 発表場所: Matsuyama, Japan, Abstract Book
  • 年月日: 2008-03-06
• [学会発表] Hydroxylated polychlorinated biphenyls in the blood of Baikal seals (Pusa sibirica). (2008)
  • 著者名/発表者名: Imaeda, D., Iwata, H., et al.
  • 学会等名: 28^<th> International Symposium on Halogenated Persistent Organic Pollutants (POPs)
  • 発表場所: Birmingham, United Kingdom
• [学会発表] Contamination status of brominated flame retardants (BFRs) in Baikal seals (Pusa sibirica). (2008)
  • 著者名/発表者名: Isobe, T., Iwata, H., et al.
  • 学会等名: 28^<th> International Symposium on Halogenated Persistent Organic Pollutants (POPs)
  • 発表場所: Birmingham, United Kingdom
• [学会発表] A novel aryl hydrocarbon receptpr isoform, 2^<nd> AHRl, in chicken(Gallus gallus) ; isolation and functional characterization. (2008)
  • 著者名/発表者名: Iwabuchi, K., Iwata, H., et al.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers
  • 発表場所: Matsuyama, Japan
• [学会発表] Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)on morphogenesis in developing red seabream(Pagrus major)embryo. (2008)
  • 著者名/発表者名: Iida, M., Iwata, H., et al.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers
  • 発表場所: Matsuyama, Japan
• [学会発表] Functional characterization of in vitro - expressed Baikal Seal cytochrome P450 1A1. (2008)
  • 著者名/発表者名: Yamaguchi, K., Kim, E. Y., Iwata, H.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers
  • 発表場所: Matsuyama, Japan
• [学会発表] Molecular characterization of the aryl hydrocarbon receptor repressor(AHRR)from chicken(Gallus gallus). (2008)
  • 著者名/発表者名: Lee, J. S., Kim, E. Y., Iwata, H.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers
  • 発表場所: Matsuyama, Japan
• [学会発表] Residue levels of OH-PCBs and PCBs in the blood of Baikal seals(Pusa sibirica). (2008)
  • 著者名/発表者名: Imaeda, D., Iwata, H., et al.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers
  • 発表場所: Matsuyama, Japan
• [学会発表] Contamination status of brominated flame retardants (BFRs)in Baikal seals(Pusas sibirica). (2008)
  • 著者名/発表者名: Isobe, T., Iwata, H., et al.
  • 学会等名: Interdisciplinary Symposium on Environmental Sciences, To Establish an Asian Network of Environmental Researchers.
  • 発表場所: Matsuyama, Japan
• [学会発表] Accumulation characteristics of hydroxylated polychlorinated biphenyl congeners in the blood of marine mammals and human. (2008)
  • 著者名/発表者名: Nomiyama, K., Iwata, H., et al.
  • 学会等名: SETAC North America 29^<th> Annual Meeting
  • 発表場所: Tampa, Florida, USA
• [学会発表] ダイオキシン類を暴露させたカワウ肝由来培養細胞における遺伝子発現変動の比較 (2008)
  • 著者名/発表者名: 仲山慶, 酒井大樹, 北村真一, 須藤明子, 金恩英, 岩田久人, 田辺信介
  • 学会等名: 第14回バイオアッセイ研究会・日本環境毒性学会合同研究発表会
  • 発表場所: 神戸, 日本
• [学会発表] バイカルアザラシCYP2BおよびCYP3Aプロモーター/エンハンサー領域の分子特性とPOPsによる転写活性化能. (2008)
  • 著者名/発表者名: 酒井大樹, 岩田久人, 金 恩英, Petrov, E. A., 田辺信介
  • 学会等名: 環境ホルモン学会第11回研究発表会
  • 発表場所: 東京, 日本
• [学会発表] Proposal of species-specific 2, 3, 7, 8-TCDD-TEF for wildlife toxicology : relative potencies for AHR-mediated responses of dioxin-like chemicals in Baikal seal and jungle crow. (2008)
  • 著者名/発表者名: Kim, E. Y., Iwata, H., et al.
  • 学会等名: 環境ホルモン学会第11回研究発表会
  • 発表場所: 東京, 日本
• [学会発表] ニワトリ新規AHR1アイソフォーム、2nd AHR1, in chicken (Gallusgallus) : mRNA expression profile andtranscriptional potency bydioxins. (2008)
  • 著者名/発表者名: 岩渕康平, 金 恩英, 安井知子, 岩田久人
  • 学会等名: 環境ホルモン学会第11回研究発表会
  • 発表場所: 東京, 日本
• [学会発表] in vitro発現させたバイカルアザラシ シトクロムP4501A1の機能特性. (2008)
  • 著者名/発表者名: 山口恵佑, 金恩英, 岩田久人
  • 学会等名: 環境ホルモン学会第11回研究発表会
  • 発表場所: 東京, 日本
• [学会発表] TCDD曝露したマダイ胚の形態学的異常 : アクアポリンおよびCYP3Aの発現量変化と神経系の撹乱. (2008)
  • 著者名/発表者名: 飯田緑, 金恩英, 村上安則, 島康洋, 岩田久人
  • 学会等名: 環境ホルモン学会第11回研究発表会
  • 発表場所: 東京, 日本
• [学会発表] Species diversity of AHR-CYP1A signaling pathways : Toward risk assessment of dioxin-like compounds in wildlife (2007)
  • 著者名/発表者名: Iwata, H. and Kim, E. Y.
  • 学会等名: International Symposium on the Environmental Risks of Chemicals
  • 発表場所: Saitama, Japan, Program and Abstracts
  • 年月日: 2007-12-10
• [学会発表] Inter-species and -isoform differences in signaling pathways of aryl hydrocarbon receptors : A casestudy of fish and bird (2007)
  • 著者名/発表者名: Iwata, H. and Kim, E. Y.
  • 学会等名: Special Seminar in Hanyang University
  • 発表場所: Seoul, Korea
  • 年月日: 2007-11-21
• [学会発表] Transactivation potentials of constitutive androstane/active receptor by persistent organic pollutants and brominated flameretardants : a comparative study of Baikal Seal ( Pusa sibirica) and mouse. (2007)
  • 著者名/発表者名: Sakai, H., Iwata, H., Kim, E.Y., Petrov, E. A. and Tanabe, S.
  • 学会等名: DIOXIN 2007 International Symposium
  • 発表場所: Tokyo, Japan Abstracts Book
  • 年月日: 2007-09-03
• [学会発表] Xenobiotic ligand profiles of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) in Baikal seal ( Pusa sibirica) (2007)
  • 著者名/発表者名: Iwata, H., Sakai, H., Kadota, M., Kim, E. Y., Tanabe, S., Batoev, V. B. and Petrov, E. A
  • 学会等名: 14^<th> International Symposium Pollutant Responses in Marine Organisms
  • 発表場所: Brazil Abstruct Book
  • 年月日: 2007-05-09
• [学会発表] Contamination by perfluorinated compounds and effects on peroxisome proliferators-activated receptor alpha-Cytochrome P450 4A signaling pathway in Baikal seal ( Pusa sibirica). (2007)
  • 著者名/発表者名: Iwata, H., Ishibashi, H., Kim, E. Y., Tao, L., Kannan, K., Tanabe, S., Batoev, V. B. and Petrov, E. A.
  • 学会等名: 14^<th> International Symposium Pollutant Responses in Marine Organisms
  • 発表場所: Brazil Abstract Book
  • 年月日: 2007-05-09
• [学会発表] Xenobiotic ligand profiles of constitutive androstane receptor(CAR)and pregnane X receptor(PXR)in Baikal seal(Pusa sibirica) (2007)
  • 著者名/発表者名: Iwata, H., et. al.
  • 学会等名: 14th International Symposium Pollutant Responses in Marine Organisms
  • 発表場所: Brazil
  • 年月日: 2007-05-07
• [図書] 第5章 生物反応を利用して化学物質汚染の危険性を検知する 分子で読む環境汚染, 鈴木聡編 (2009)
  • 著者名/発表者名: 岩田久人, 金 恩英
  • 出版者: 東海大学出版会(印刷中)
• [図書] 第5章生物反応を利用して化学物質汚染の危険性を検知する, 分子で読む環境汚染 (2008)
  • 著者名/発表者名: 岩田久人・金恩英
  • 出版者: 鈴木聡編,東海大学出版会
• [図書] 日本環境毒性学会, 畠山成久編, アイピーシー (2006)
  • 著者名/発表者名: 岩田久人
  • 出版者: 第6章バイオマーカーによる影響評価, 化学物質の生態リスク評価と規制-農薬編-
• [図書] 化学物質の生態リスク評価と規制-農薬編- (2006)
  • 著者名/発表者名: 岩田 久人
  • 総ページ数: 366
  • 出版者: アイピーシー