メタボリックシンドロームの分子基盤としての脂肪細胞分泌因子の臨床的実験的研究

• 研究課題/領域番号: 17390271
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 内分泌学
• 研究機関: 大阪大学
• 研究代表者: 船橋 徹 大阪大学, 医学系研究科, 助教授 (60243234)
• 研究分担者: 中村 正 大阪大学, 医学系研究科, 講師 (90252668) ; 木原 進士 大阪大学, 医学系研究科, 助手 (20332736)
• 研究期間 (年度): 2005 – 2006
• 研究課題ステータス: 完了 (2006年度)
• 配分額: 14,600千円 (直接経費: 14,600千円); 2006年度: 6,700千円 (直接経費: 6,700千円); 2005年度: 7,900千円 (直接経費: 7,900千円)
• キーワード: 遺伝子 / 内科 / 循環器・高血圧 / プロテオーム / 糖尿病

研究概要

メタボリックシンドロームはインスリン抵抗性、脂質異常、高血圧を合併する病態で動脈硬化疾患の易発症基盤である。私達は脂肪組織が多彩な生理活性物質を分泌する巨大な内分泌臓器であることを見出し数々の新規遺伝子を発見しアディポサイトカインと概念付けた。本研究は、Adiponectin, Visfatin, Glycerolという3つの脂肪細胞分泌因子に焦点をあて、メタボリックシンドロームの病態解析をおこなった。1)Adiponectinについては、その欠乏が食塩依存性高血圧をきたし、心筋虚血や圧負荷、血管への易血栓刺激に対し炎症シグナルや肥大化シグナルを活性化させ、虚血再還流障害、心拡張障害、血栓形成に繋がる分子メカニズムを実験的に示した。臨床的にも低Adiponectin血症が冠動脈複雑性病変やスパスム、心筋拡張障害、末梢動脈疾患と関わることを示した。特に心血管エベントの予測因子としての低Adiponectin血症のエビデエンスが蓄積された。糖尿病関連では低Adiponectin血症の糖尿病発症リスクとしてのエビデエンス、インスリン抵抗性指標としての意義を報告し、慢性腎臓病の心血管疾患発症リスクとしての低Adiponectin血症の意義を示した。低Adiponectin血症対策として禁煙も含めたライフスタイル改善の意義を報告し、酸化ストレス減少、核内受容体活性化薬剤などの低Adiponectin血症改善機構について明らかにした。2)Visfatinについては発現増加に低酸素が関与することが明らかになった。3)Glycerolについてはノックアウトマウス解析で、Aquaporin7がGlycerolのチャネル分子として機能することを示してきたが、詳細な解析により、本分子の欠損が細胞内グリセロールを活性化し肥満に関わる新しいメカニズムが明らかになった。

研究成果

• [雑誌論文] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. (2007)
  • 著者名/発表者名: Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H
  • 雑誌名: Atherosclerosis. (In press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • 著者名/発表者名: Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H
  • 雑誌名: Atherosclerosis. (In press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. (2007)
  • 著者名/発表者名: Matsuhisa M, Yamasaki Y, Emoto M, Shimabukuro M, Funahashi T, Matsuzawa Y
  • 雑誌名: Diabetes Res Clin Pract (In press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes : The Korean atherosclerosis study (KAS) A 42-month prospective study. (2007)
  • 著者名/発表者名: Lim S, Koo BK, Cho SW, Kihara S, Funahashi T, Cho YM, Kim SY, Lee HK, Shimomura I, Park KS
  • 雑誌名: Atherosclerosis. (In press)
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. (2007)
  • 著者名/発表者名: Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H.
  • 雑誌名: Atherosclerosis. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • 著者名/発表者名: Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H.
  • 雑誌名: Atherosclerosis. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. (2007)
  • 著者名/発表者名: Matsuhisa M, Yamasaki Y, Emoto M, Shimabukuro M, Funahashi T, Matsuzawa Y.
  • 雑誌名: Diabetes Res Clin Pract. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes : The Korean atherosclerosis study (KAS) A 42-month prospective study. (2007)
  • 著者名/発表者名: Lim S, Koo BK, Cho SW, Kihara S, Funahashi T, Cho YM, Kim SY, Lee HK, Shimomura I, Park KS.
  • 雑誌名: Atherosclerosis. (in press)
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. (2007)
  • 著者名/発表者名: Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H.
  • 雑誌名: Atherosclerosis. (In press)
• [雑誌論文] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • 著者名/発表者名: Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H.
  • 雑誌名: Atherosclerosis. (In press)
• [雑誌論文] A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. (2007)
  • 著者名/発表者名: Matsuhisa M, Yamasaki Y, Emoto M, Shimabukuro M, Funahashi T, Matsuzawa Y.
  • 雑誌名: Diabetes Res Clin Pract (In press)
• [雑誌論文] High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels (2006)
  • 著者名/発表者名: Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S
  • 雑誌名: Int J Cancer 118 ページ: 1414-1419
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin and inflammatory markers in peripheral arterial occlusive disease. (2006)
  • 著者名/発表者名: Iwashima Y, Horio T, Suzuki Y, Kihara S, Rakugi H, Kangawa K, Funahashi T, Ogihara T, Kawano Y
  • 雑誌名: Atherosclerosis. 188 ページ: 384-390
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin acts as an endogenous antithrombotic factor. (2006)
  • 著者名/発表者名: Kato H, Kashiwagi H, Shiraga M, Tadokoro S, Kamae T, Ujiie H, Honda S, Miyata S, Ijiri Y, Yamamoto J, Maeda N, Funahashi T, Kurata Y, Shimomura I, Tomiyama Y, Kanakura Y
  • 雑誌名: Arterioscler Thromb Vasc Biol. 26 ページ: 224-230
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Identification of amino-terminal region of adiponectin as a physiologically functional domain. (2006)
  • 著者名/発表者名: Ujiie H, Oritani K, Kato H, Yokota T, Takahashi I, Maeda T, Masaie H, Ichii M, Kamada Y, Tamura S, Kihara S, Funahashi T, Tomiyama Y, Kanakura Y
  • 雑誌名: J Cell Biochem. 98 ページ: 194-207
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates (2006)
  • 著者名/発表者名: Pannacciulli N, Bunt JC, Ortega E, Funahashi T, Salbe AD, Bogardus C, Krakoff J
  • 雑誌名: J Clin Endocrinol Metab. 91 ページ: 1600-1603
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipients. (2006)
  • 著者名/発表者名: Bakkaloglu SA, Soylemezoglu O, Buyan N, Oktar SO, Funahashi T, Pasaoglu H, Elhan AH, Peru H, Hasanoglu E
  • 雑誌名: Pediatr Transplant. 10 ページ: 187-192
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin replenishment ameliorates obesity-related hypertension. (2006)
  • 著者名/発表者名: Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I
  • 雑誌名: Hypertension. 47 ページ: 1108-1116
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice (2006)
  • 著者名/発表者名: Bauche IB, Ait El Mkadem S, Rezsohazy R, Funahashi T, Maeda N, Miranda LM, Brichard SM
  • 雑誌名: Biochem Biophys Res Commun 345 ページ: 1414-1424
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (2006)
  • 著者名/発表者名: Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N
  • 雑誌名: World J Castroenterol. 12 ページ: 3352-3358
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Effect of adiponectin on murine colitis induced by dextran sulfate sodium. (2006)
  • 著者名/発表者名: Nishihawa T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T, Shimomura I
  • 雑誌名: Gastroenterology 131 ページ: 853-861
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Visfatin in adipocytes is upregulated by hypoxia through HIFlalpha-dependent mechanism. (2006)
  • 著者名/発表者名: Segawa K, Fukuhara A, Hosogai N, Morita K, Okuno Y, Tanaka M, Nakagawa Y, Kihara S, Funahashi T, Komuro R, Matsuda M, Shimomura I
  • 雑誌名: Biochem Biophys Res Commun 349 ページ: 875-882
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin and renal function, and implication as a risk of cardiovascular disease. (2006)
  • 著者名/発表者名: Iwashima Y, Horio T, Kumada M, Suzuki Y, Kihara S, Rakugi H, Kawano Y, Funahashi T, Ogihara T
  • 雑誌名: Am J Cardiol. 98 ページ: 1603-1608
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease (2006)
  • 著者名/発表者名: Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H
  • 雑誌名: J Am Coll Cardiol 48 ページ: 1155-1162
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta. (2006)
  • 著者名/発表者名: Kadowaki K, Waguri M, Nakanishi I, Miyashita Y, Nakayama M, Suehara N, Funahashi T, Shimomura I, Fujita T
  • 雑誌名: J Clin Endocrinol Metab 91 ページ: 5090-5094
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. (2006)
  • 著者名/発表者名: Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M
  • 雑誌名: Circ J. 7011 ページ: 1437-1442
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women : the hoorn study. (2006)
  • 著者名/発表者名: Snijder MB, Heine RJ, Seidell JC, Bouter LM, Stehouwer CD, Nijpels G, Funahashi T, Matsuzawa Y, Shimomura I, Dekker JM
  • 雑誌名: Diabetes Care. 29 ページ: 2498-2503
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Blockade of Angiotensin II type-I receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. (2006)
  • 著者名/発表者名: Kurata A, Nishizawa H, Kihara S, Maeda N, Sonoda M, Okada T, Ohashi K, Hibuse T, Fujita K, Yasui A, Hiuge A, Kumada M, Kuriyama H, Shimomura I, Funahashi T
  • 雑誌名: Kidney Int. 70 ページ: 1717-1724
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. (2006)
  • 著者名/発表者名: Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S.
  • 雑誌名: Int J Cancer. 118 ページ: 1414-1419
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin and inflammatory markers in peripheral arterial occlusive disease. (2006)
  • 著者名/発表者名: Iwashima Y, Horio T, Suzuki Y, Kihara S, Rakugi H, Kangawa K, Funahashi T, Ogihara T, Kawano Y.
  • 雑誌名: Atherosclerosis. 188 ページ: 384-390
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin acts as an endogenous antithrombotic factor. (2006)
  • 著者名/発表者名: Kato H, Kashiwagi H, Shiraga M, Tadokoro S, Kamae T, Ujiie H, Honda S, Miyata S, Ijiri Y, Yamamoto J, Maeda N, Funahashi T, Kurata Y, Shimomura I, Tomiyama Y, Kanakura Y.
  • 雑誌名: Arterioscler Thromb Vasc Biol. 26 ページ: 224-230
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Identification of amino-terminal region of adiponectin as a physiologically functional domain. (2006)
  • 著者名/発表者名: Ujiie H, Oritani K, Kato H, Yokota T, Takahashi I, Maeda T, Masaie H, Ichii M, Kamada Y, Tamura S, Kihara S, Funahashi T, Tomiyama Y, Kanakura Y.
  • 雑誌名: J Cell Biochem. 98 ページ: 194-207
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates. (2006)
  • 著者名/発表者名: Pannacciulli N, Bunt JC, Ortega E, Funahashi T, Salbe AD, Bogardus C, KrakoffJ
  • 雑誌名: J Clin Endocrinol Metab. 91 ページ: 1600-1603
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipients. (2006)
  • 著者名/発表者名: Bakkaloglu SA, Soylemezoglu O, Buyan N, Oktar SO, Funahashi T, Pasaoglu H, Elhan AH, Peru H, Hasanoglu E.
  • 雑誌名: Pediatr Transplant. 10 ページ: 187-192
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin replenishment ameliorates obesity-related hypertension. (2006)
  • 著者名/発表者名: Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I.
  • 雑誌名: Hypertension. 47 ページ: 1108-1116
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. (2006)
  • 著者名/発表者名: Bauche IB, Ait El Mkadem S, Rezsohazy R, Funahashi T, Maeda N, Miranda LM, Brichard SM.
  • 雑誌名: Biochem Biophys Res Commun. 345 ページ: 1414-1424
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (2006)
  • 著者名/発表者名: Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N.
  • 雑誌名: World J Gastroenterol. 12 ページ: 3352-3358
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Effect of adiponectin on murine colitis induced by dextran sulfate sodium. (2006)
  • 著者名/発表者名: Nishihara T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T, Shimomura I.
  • 雑誌名: Gastroenterology. 131 ページ: 853-861
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. (2006)
  • 著者名/発表者名: Segawa K, Fukuhara A, Hosogai N, Morita K, Okuno Y, Tanaka M, Nakagawa Y, Kihara S, Funahashi T, Komuro R, Matsuda M, Shimomura I.
  • 雑誌名: Biochem Biophys Res Commun. 349 ページ: 875-882
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin and renal function, and implication as a risk of cardiovascular disease. (2006)
  • 著者名/発表者名: Iwashima Y, Horio T, Kumada M, Suzuki Y, Kihara S, Rakugi H, Kawano Y, Funahashi T, Ogihara T.
  • 雑誌名: Am J Cardiol. 98 ページ: 1603-1608
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. (2006)
  • 著者名/発表者名: Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H.
  • 雑誌名: J Am Coll Cardiol. 48 ページ: 1155-1162
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta. (2006)
  • 著者名/発表者名: Kadowaki K, Waguri M, Nakanishi I, Miyashita Y, Nakayama M, Suehara N, Funahashi T, Shimomura I, Fujita T.
  • 雑誌名: J Clin Endocrinol Metab. 91 ページ: 5090-5094
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. (2006)
  • 著者名/発表者名: Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M.
  • 雑誌名: Circ J. 701 ページ: 1437-1442
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women : the hoorn study. (2006)
  • 著者名/発表者名: Snijder MB, Heine RJ, Seidell JC, Bouter LM, Stehouwer CD, Nijpels G, Funahashi T, Matsuzawa Y, Shimomura I, Dekker JM.
  • 雑誌名: Diabetes Care. 29 ページ: 2498-2503
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. (2006)
  • 著者名/発表者名: Kurata A, Nishizawa H, Kihara S, Maeda N, Sonoda M, Okada T, Ohashi K, Hibuse T, Fujita K, Yasui A, Hiuge A, Kumada M, Kuriyama H, Shimomura I, Funahashi T.
  • 雑誌名: Kidney Int. 70 ページ: 1717-1724
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels (2006)
  • 著者名/発表者名: Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S.
  • 雑誌名: Int J Cancer 118 ページ: 1414-1419
• [雑誌論文] Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (2006)
  • 著者名/発表者名: Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N
  • 雑誌名: World J Gastroenterol. 12 ページ: 3352-3358
• [雑誌論文] Effect of adiponectin on murine colitis induced by dextran sulfate sodium. (2006)
  • 著者名/発表者名: Nishihara T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T, Shimomura I
  • 雑誌名: Gastroenterology 131 ページ: 853-861
• [雑誌論文] Visfatin in adipocytes is upregulated by hypoxia through HIF lalpha-dependent mechanism. (2006)
  • 著者名/発表者名: Segawa K, Fukuhara A, Hosogai N, Morita K, Okuno Y, Tanaka M, Nakagawa Y, Kihara S, Funahashi T, Komuro R, Matsuda M, Shimomura I
  • 雑誌名: Biochem Biophys Res Commun 349 ページ: 875-882
• [雑誌論文] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. (2005)
  • 著者名/発表者名: Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura
  • 雑誌名: Proc Natl Acad Sci U S A. 102 ページ: 10993-10998
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Association of hypoadiponectin-emia with smoking habit in men. (2005)
  • 著者名/発表者名: Iwashima Y, Katsuya T, Ishikawa K, Kida I, Ohishi M, Horio T, Ouchi N, Ohashi K, Kihara S, Funahashi T, Rakugi H, Ogihara T
  • 雑誌名: Hypertension. 45 ページ: 1094-1100
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. (2005)
  • 著者名/発表者名: Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, Yamaguchi T, Funahashi T, Matsuzawa Y, Nakamura T, Shimomura I
  • 雑誌名: Diabetes Care 28 ページ: 451-453
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Hypoadiponectinemia is associated with coronary artery spasm in men. (2005)
  • 著者名/発表者名: Maruyoshi H, Kojima S, Otsuka F, Funahashi T, Kaikita K, Sugiyama S, Sakamoto T, Yoshimura M, Shimomura I, Ogawa H
  • 雑誌名: Circ J. 69 ページ: 1154-1156
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. (2005)
  • 著者名/発表者名: Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K
  • 雑誌名: Nat Med 11 ページ: 1096-1103
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. (2005)
  • 著者名/発表者名: Liao Y, Takashima S, Maeda N, Ouchi N, Komamura K, Shimomura I, Hori M, Matsuzawa Y, Funahashi T, Kitakaze M
  • 雑誌名: Cardiovasc Res. 67 ページ: 705-713
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin Inhibits Endothelial Synthesis of Interleukin-8. (2005)
  • 著者名/発表者名: Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M
  • 雑誌名: Circ Res. 97 ページ: 1245-1252
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. (2005)
  • 著者名/発表者名: Kojima S, Funahashi T, Maruyoshi H, Honda O, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H
  • 雑誌名: Thromb Res. 115 ページ: 483-490
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. (2005)
  • 著者名/発表者名: Yamamoto K, Kiyohara T, Murayama Y, Kihara S, Okamoto Y, Funahashi T, Ito T, Nezu R, Tsutsui S, Miyagawa JI, Tamura S, Matsuzawa Y, Shimomura I, Shinomura Y
  • 雑誌名: Gut. 54 ページ: 789-796
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Pioglitazone improves left ventricular diastolic function in patients with essential hypertension. (2005)
  • 著者名/発表者名: Horio T, Suzuki M, Suzuki K, Takamisawa I, Hiuge A, Kamide K, Takiuchi S, Iwashima Y, Kihara S, Funahashi T, Yoshimasa Y, Kawano Y
  • 雑誌名: Am J Hypertens. 18 ページ: 949-957
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. (2005)
  • 著者名/発表者名: Guebre-Egziabher F, Bernhard J, Funahashi T, Hadj-Aissa A, Fouque D
  • 雑誌名: Nephrol Dial Transplant. 20 ページ: 129-134
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. (2005)
  • 著者名/発表者名: de Courten BV, Hanson RL, Funahashi T, Lindsay RS, Matsuzawa Y, Tanaka S, Thameem F, Gruber JD, Froguel P, Wolford JK
  • 雑誌名: Diabetes. 54 ページ: 284-289
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. (2005)
  • 著者名/発表者名: Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E
  • 雑誌名: Pediatr Nephrol. 20 ページ: 474-477
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Lifestyle modification improves risk factors in type 2 diabetes relatives. (2005)
  • 著者名/発表者名: Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y, Jansson PA
  • 雑誌名: Diabetes Res Clin Pract. 68 ページ: 18-28
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Reciprocal association of plasma adiponectin and serum C-reactive protein concentration in haemodialysis patients with end-stage kidney disease-a follow-up study. (2005)
  • 著者名/発表者名: Ignacy W, Chudek J, Adamczak M, Funahashi T, Matsuzawa Y, Kokot F, Wiecek A
  • 雑誌名: Nephron Clin Pract. 101
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients (2005)
  • 著者名/発表者名: Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O
  • 雑誌名: Perit Dial Int. 25 ページ: 357-361
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Resting metabolic rate is an important predictor of serum adiponectin concentrations : potential implications for obesity-related disorders. (2005)
  • 著者名/発表者名: Ruige JB, Ballaux DP, Funahashi T, Mertens IL, Matsuzawa Y, Van Gaal LF
  • 雑誌名: Am J Clin Nutr 82 ページ: 21-25
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. (2005)
  • 著者名/発表者名: Tan GD, Debard C, Funahashi T, Humphreys SM, Matsuzawa Y, Frayn KN, Karpe F, Vidal H
  • 雑誌名: Diabetologia 48 ページ: 1585-1589
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation. (2005)
  • 著者名/発表者名: Mertens I, Ballaux D, Funahashi T, Matsuzawa Y, Van der Planken M, Verrijken A, Ruige JB, Van Gaal LF
  • 雑誌名: Thromb Haemost 94 ページ: 1190-1195
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. (2005)
  • 著者名/発表者名: Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura I.
  • 雑誌名: Proc Natl Acad Sci U S A. 102 ページ: 10993-10998
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Association of hypoadiponectin-emia with smoking habit in men. (2005)
  • 著者名/発表者名: Iwashima Y, Katsuya T, Ishikawa K, Kida I, Ohishi M, Horio T, Ouchi N, Ohashi K, Kihara S, Funahashi T, Rakugi H, Ogihara T.
  • 雑誌名: Hypertension. 45 ページ: 1094-1100
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. (2005)
  • 著者名/発表者名: Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, Yamaguchi T, Funahashi T, Matsuzawa Y, Nakamura T, Shimomura I.
  • 雑誌名: Diabetes Care. 28 ページ: 451-453
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Hypoadiponectinemia is associated with coronary artery spasm in men. (2005)
  • 著者名/発表者名: Maruyoshi H, Kojima S, Otsuka F, Funahashi T, Kaikita K, Sugiyama S, Sakamoto T, Yoshimura M, Shimomura I, Ogawa H.
  • 雑誌名: Circ J. 69 ページ: 1154-1156
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK-and COX-2-dependent mechanisms. (2005)
  • 著者名/発表者名: Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K.
  • 雑誌名: Nat Med. 11 ページ: 1096-1103
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. (2005)
  • 著者名/発表者名: Liao Y, Takashima S, Maeda N, Ouchi N, Komamura K, Shimomura I, Hori M, Matsuzawa Y, Funahashi T, Kitakaze M.
  • 雑誌名: Cardiovasc Res. 67 ページ: 705-713
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin Inhibits Endothelial Synthesis of Interleukin-8. (2005)
  • 著者名/発表者名: Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M.
  • 雑誌名: Circ Res. 97 ページ: 1245-1252
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. (2005)
  • 著者名/発表者名: Kojima S, Funahashi T, Maruyoshi H, Honda O, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H.
  • 雑誌名: Thromb Res. 115 ページ: 483-490
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Pioglitazone improves left ventricular diastolic function in patients with essential hypertension. (2005)
  • 著者名/発表者名: Horio T, Suzuki M, Suzuki K, Takamisawa I, Hiuge A, Kamide K, Takiuchi S, Iwashima Y, Kihara S, Funahashi T, Yoshimasa Y, Kawano Y.
  • 雑誌名: Am J Hypertens. 18 ページ: 949-957
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. (2005)
  • 著者名/発表者名: Guebre-Egziabher F, Bernhard J, Funahashi T, Hadj-Aissa A, Fouque D.
  • 雑誌名: Nephrol Dial Transplant. 20 ページ: 129-134
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. (2005)
  • 著者名/発表者名: de Courten BV, Hanson RL, Funahashi T, Lindsay RS, Matsuzawa Y, Tanaka S, Thameem F, Gruber JD, Froguel P, Wolford JK.
  • 雑誌名: Diabetes. 54 ページ: 284-289
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. (2005)
  • 著者名/発表者名: Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E.
  • 雑誌名: Pediatr Nephrol. 20 ページ: 474-477
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Lifestyle modification improves risk factors in type 2 diabetes relatives. (2005)
  • 著者名/発表者名: Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y, Jansson PA.
  • 雑誌名: Diabetes Res Clin Pract. 68 ページ: 18-28
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Reciprocal association of plasma adiponectin and serum C-reactive protein concentration in haemodialysis patients with end-stage kidney disease-a follow-up study. (2005)
  • 著者名/発表者名: Ignacy W, Chudek J, Adamczak M, Funahashi T, Matsuzawa Y, Kokot F, Wiecek A.
  • 雑誌名: Nephron Clin Pract. 101
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients. (2005)
  • 著者名/発表者名: Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O.
  • 雑誌名: Perit Dial Int. 25 ページ: 357-361
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Resting metabolic rate is an important predictor of serum adiponectin concentrations : potential implications for obesity-related disorders. (2005)
  • 著者名/発表者名: Ruige JB, Ballaux DP, Funahashi T, Mertens IL, Matsuzawa Y, Van Gaal LF.
  • 雑誌名: Am J Clin Nutr. 82 ページ: 21-25
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. (2005)
  • 著者名/発表者名: Tan GD, Debard C, Funahashi T, Humphreys SM, Matsuzawa Y, Frayn KN, Karpe F, Vidal H.
  • 雑誌名: Diabetologia. 48 ページ: 1585-1589
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation. (2005)
  • 著者名/発表者名: Mertens I, Ballaux D, Funahashi T, Matsuzawa Y, Van der Planken M, Verrijken A, Ruige JB, Van Gaal LF.
  • 雑誌名: Thromb Haemost. 94 ページ: 1190-1195
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase (2005)
  • 著者名/発表者名: Hibuse T, Maeda N, Funahashi T.Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura I
  • 雑誌名: Proc Natl Acad Sci U S A. 102 ページ: 10993-10998
• [雑誌論文] A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance (2005)
  • 著者名/発表者名: Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, Yamaguchi T, Funahashi T, Matsuzawa Y, Nakamura T, Shimomura I
  • 雑誌名: Diabetes Care. 28 ページ: 451-453
• [雑誌論文] Visfatin : A protein secreted by visceral fat that mimics the effects of insulin. (2005)
  • 著者名/発表者名: Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I
  • 雑誌名: Science. 307 ページ: 426-430
• [雑誌論文] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease (2005)
  • 著者名/発表者名: Yamamoto K, Kiyohara T, Murayama Y, Kihara S, Okamoto Y, Funahashi T, Ito T, Nezu R, Tsutsui S, Miyagawa JI, Tamura S, Matsuzawa Y, Shimomura I, Shinomura Y.
  • 雑誌名: Gut 54 ページ: 789-796
• [雑誌論文] Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. (2005)
  • 著者名/発表者名: Kojima S, Funahashi T, Maruyoshi H, Honda o, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H
  • 雑誌名: Thromb Res 115 ページ: 483-490
• [雑誌論文] Pioglitazone improves left ventricular diastolic function in patients with essential hypertension. (2005)
  • 著者名/発表者名: Horio T, Suzuki M, Suzuki K, Takamisawa I, Hiuge A, Kamide K, Takiuchi S, Iwashima Y, Kihara S, Funahashi T, Yoshimasa Y, Kawano Y.
  • 雑誌名: Am J Hypertens 18 ページ: 949-957
• [雑誌論文] Lifestyle modification improves risk factors in type 2 diabetes relatives (2005)
  • 著者名/発表者名: Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y, Jansson PA.
  • 雑誌名: Diabetes Res Clin Pract. 68 ページ: 18-28
• [雑誌論文] Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients. (2005)
  • 著者名/発表者名: Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O
  • 雑誌名: Perit Dial Int. 25 ページ: 357-361
• [雑誌論文] Resting metabolic rate is an important predictor of serum adiponectin concentrations : potential implications for obesity-related disorders (2005)
  • 著者名/発表者名: Ruige JB, Ballaux DP, Funahashi T, Mertens IL, Matsuzawa Y, Van Gaal LF
  • 雑誌名: Am J Clin Nutr. 82 ページ: 21-25