マカク類の感染症が宿主の行動に与える影響とそのリスク評価

• 研究課題/領域番号: 17F17093
• 研究種目: 特別研究員奨励費
• 配分区分: 補助金
• 応募区分: 外国
• 研究分野: 進化生物学
• 研究機関: 京都大学
• 研究代表者: MacIntosh Andrew 京都大学, 霊長類研究所, 准教授 (30623136)
• 研究分担者: DUBOSCQ JULIE 京都大学, 霊長類研究所, 外国人特別研究員
• 研究期間 (年度): 2017-10-13 – 2020-03-31
• 研究課題ステータス: 交付 (2018年度)
• 配分額: 2,100千円 (直接経費: 2,100千円); 2018年度: 900千円 (直接経費: 900千円); 2017年度: 900千円 (直接経費: 900千円)
• キーワード: social transmission / simian foamy virus / macaque / strain genetic profile

研究実績の概要

The aim of the research is to foster a better understanding of pathogen transmission in social animals. The study of pathogens expressing enough genetic diversity that different strains can be identified helps tracking transmission characteristics, e.g. simian foamy virus (SFV) and E. coli. Strain genetic profile is then linked to individual social profile: individuals more frequently in contact with each other should share more similar strains than others. The fellow collected data on two groups of two species of socially-housed captive macaques at the PRI. Early analyses show that young macaques seem not infected by SFV before reaching 2 yo. Strain sharing within a dyad seems related to similarity in age and to grooming frequency, indicating horizontal or oblique transmission.

現在までの達成度 (区分)

3: やや遅れている

理由

This project is a development of a previous study conducted at PRI with the same host and collaborators so its feasibility was assessed as high. Unfortunately, several issues impeded significant progress: 1/ whole-group sampling of saliva, necessary to get virus genetic material, from the socially-housed captive groups where behavioral observation was also conducted did not take place in fall 2017. Only a limited number of monkeys have been re-sampled this year; 2/ virus genetic profiling turned out to be efficient and specific only for Japanese macaques, not for Rhesus macaques, so molecular analyses have stalled; 3/ The fellow became pregnant, which prevented some types of lab work, again slowing down progress.

今後の研究の推進方策

The major activities in 2018 were planned as 1/ behavioural observations, 2/ DNA/RNA extraction, genotyping and sequencing and 3/ analysis of these data together. The end of the year was to be devoted to another saliva sampling during the annual health check. The plan was also to participate in an international conference to present this work. Major costs should have concerned consumables and travels.

This plan is postponed as I will be on maternity leave from June 26th until spring next year. In the meantime, the fellow is analysing the data already collected and supervising student projects on related topics.

研究成果

• [雑誌論文] The influence of phylogeny, social style, and sociodemographic factors on macaque social network structure. (2018)
  • 著者名/発表者名: Balasubramaniam, K. N., Beisner, B. A., Berman, C. M., de Marco, A., Duboscq, J., Koirala, S., Majolo, B., MacIntosh, A. J. J., McFarland, R., Molesti, S., Ogawa, H., Petit, O., Schino, G., Sosa, S., Sueur, C., Thierry, B., de Waal, F. B. M, & McCowan, B. J.
  • 雑誌名: American Journal of Primatology 巻: 80(1) 号: 1
  • DOI: 10.1002/ajp.22727
  • 査読あり / 国際共著
• [雑誌論文] Diffusion Studies (2017)
  • 著者名/発表者名: Duboscq Julie
  • 雑誌名: Encyclopedia of Animal Cognition and Behavior 巻: na ページ: 1-6
  • DOI: 10.1007/978-3-319-47829-6_1593-1
  • ISBN: 9783319478296
  • 査読あり / 国際共著
• [雑誌論文] One step at a time in investigating relationships between self-directed behaviours and parasitological, social and environmental variables (2017)
  • 著者名/発表者名: Duboscq Julie、Romano Val?ria、Sueur C?dric、MacIntosh Andrew J. J.
  • 雑誌名: Royal Society Open Science 巻: 4 号: 8 ページ: 170461-170461
  • DOI: 10.1098/rsos.170461
  • 査読あり / オープンアクセス / 国際共著
• [学会発表] Connecting the dots: linking host behaviour to parasite transmission and infection risk (2017)
  • 著者名/発表者名: Duboscq J. & MacIntosh A.
  • 学会等名: 7th meeting of the European Federation for Primatology
  • 国際学会
• [学会発表] What happens next? Using relational event modelling to investigate temporal social dynamics in macaques (2017)
  • 著者名/発表者名: Duboscq, J.
  • 学会等名: 11th meeting of the Gottinger Freilandtage
  • 国際学会
• [学会発表] Infection patterns of simian foamy virus in macaques (2017)
  • 著者名/発表者名: Duboscq, J., Okamoto, M., & MacIntosh, A.
  • 学会等名: 7th meeting of the European Federation for Primatology
  • 国際学会
• [学会発表] Infection patterns of simian foamy virus in macaques (2017)
  • 著者名/発表者名: Duboscq, J., Okamoto, M., & MacIntosh
  • 学会等名: Meeting of the French Society of the Study of Animal Behaviour
  • 国際学会