ガス分子を介した新しい生体制御機構の学際的アプローチによる解明と医学への応用

• 研究課題/領域番号: 17GS0419
• 研究種目: 学術創成研究費
• 配分区分: 補助金
• 研究機関: 慶應義塾大学
• 研究代表者: 末松 誠 慶應義塾大学, 医学部, 教授 (00206385)
• 研究分担者: 斎藤 正男 (齋藤 正男) 東北大学, 多元物質研究所, 教授 (70302239) ; 曽我 朋義 慶應義塾大学, 環境情報学部, 教授 (60338217) ; 平尾 敦 金沢大学, がん研究所, 教授 (90343350) ; 田中 廣壽 (田中 広寿) 東京大学, 医科学研究所, 准教授 (00171794) ; 足立 健 慶應義塾大学, 医学部, 准教授 (50231931)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 331,110千円 (直接経費: 254,700千円、間接経費: 76,410千円); 2009年度: 64,350千円 (直接経費: 49,500千円、間接経費: 14,850千円); 2008年度: 64,350千円 (直接経費: 49,500千円、間接経費: 14,850千円); 2007年度: 64,350千円 (直接経費: 49,500千円、間接経費: 14,850千円); 2006年度: 64,350千円 (直接経費: 49,500千円、間接経費: 14,850千円); 2005年度: 73,710千円 (直接経費: 56,700千円、間接経費: 17,010千円)
• キーワード: 一酸化炭素 / ガスバイオロジー / 酸素センサー / メタボローム / cytochrome oxidase / 構造生物学 / ミトコンドリア / Hypoxia inducible factor / 生体情報工学 / グルタチオン / 一酸化窒素

研究概要

ガス分子の受容体探索は、それ自体の技術的困難と、異なるガス分子と受容体が構成する複雑なフィードバックが交錯する代謝システムの系統的解析が困難であったために未開の領域であった。本プロジェクトではメタボロームと分子質量イメージングなどの最新の質量分析技術と計算機科学による予測生物学的アプローチを駆使してこの問題を解決し、新しい酸素センシング機構やストレス応答で変動するCO, NO, H2Sを介した細胞機能制御機構を発見し、それらが構成する複雑かつ精妙なガス分子感受性代謝システム制御機構の存在が示唆された。

研究成果

• [雑誌論文] Regulation of the HIF-1α level is essential for hematopoietic stem cells. (2010)
  • 著者名/発表者名: Takubo K, Goda N, Yamada W, Ikeda E Kubota Y, Shima H Johnson RS, Hirao A, Suematsu M, Suda T
  • 雑誌名: Cell Stem Cell (in press)
• [雑誌論文] Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry. (2010)
  • 著者名/発表者名: Hattori K, Kajimura M, Nakanishi T, Fujiwake H, Ogawa K, Nagahata Y, Hishiki T, Kubo A, Setou M, Suematsu M
  • 雑誌名: Antioxid Redox Signal (In press)
• [雑誌論文] von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina. (2010)
  • 著者名/発表者名: Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, M. Simon C, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
  • 雑誌名: Development 137(9) ページ: 1563-1571
• [雑誌論文] Interactions of multiple gas-transducing systems: Hallmarks and uncertainties of CO, NO and H2S gas biology. (2010)
  • 著者名/発表者名: Kajimura M, Fukuda R, Bateman RM, Yamamoto T, Suematsu M
  • 雑誌名: Antioxid Redox Signal (In press)
• [雑誌論文] TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. (2010)
  • 著者名/発表者名: Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A
  • 雑誌名: Nature 463 ページ: 676-680
• [雑誌論文] Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver (2010)
  • 著者名/発表者名: Sakuragawa T, Hishiki T, Ueno Y, Ikeda S, Soga T, Yachie-Kinoshita A, Kajimura M, Suematsu M.
  • 雑誌名: J Clin Biochem Nutr 46(2) ページ: 126-134
  • NAID: 130004466603
  • 査読あり
• [雑誌論文] von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina (2010)
  • 著者名/発表者名: Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, M.Simon C, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H.
  • 雑誌名: Development (in press)
  • 査読あり
• [雑誌論文] Interactions of multiple gas-transducing systems : Hallmarks and uncertainties of CO, NO and H_2S gas biology (2010)
  • 著者名/発表者名: Kajimura M, Fukuda R, Bateman RM, Yamamoto T, Suematsu M.
  • 雑誌名: Antioxid. Redox Signal. (In press(Invited review))
  • 査読あり
• [雑誌論文] Phosphorescence-assisted microvascular O_2 measurements reveal alterations of oxygen demand in human metastatic colan cancer in the liver of superimmunodeficient NOG mice (2010)
  • 著者名/発表者名: Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K.
  • 雑誌名: Adv Exp Med Biol. 662 ページ: 423-429
  • 査読あり
• [雑誌論文] T-state stabilization of hemoglobin by nitric oxide to form α-nitrosyl heme causes constitutive release of ATP from human erythrocytes (2010)
  • 著者名/発表者名: Akatsu T, Tsukada K, Hishiki T, Suga-Numa K, Tanabe M, Shimazu M, Kitagawa Y, Yachie-Kinoshita A, Suematsu M.
  • 雑誌名: Adv Exp Med Biol. 662 ページ: 109-114
  • 査読あり
• [雑誌論文] Assessing a shift of glucose biotransformation by LC-MS/MS-based metabolome analysis in carbon monoxide-exposed cells (2010)
  • 著者名/発表者名: Takano N, Yamamoto T, Adachi T, Suematsu M.
  • 雑誌名: Adv Exp Med Biol. 662 ページ: 101-107
  • 査読あり
• [雑誌論文] The Effects of cilostazol on tissue oxygenation upon an ischemic-reperfusion injury in the mouse cerebrum (2010)
  • 著者名/発表者名: Morikawa T, Hattori K, Kajimura M, Suematsu M.
  • 雑誌名: Adv Exp Med Biol. 662 ページ: 89-94
  • 査読あり
• [雑誌論文] Fenofibrate, a peroxisome proliferator-activated receptor α agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty liver in mice (2010)
  • 著者名/発表者名: Kondo K, Sugioka T, Tsukada K, Aizawa M, Takizawa M, Shimizu K, Morimoto M, Suematsu M, Goda N.
  • 雑誌名: Adv Exp Med Biol. 662 ページ: 77-82
  • 査読あり
• [雑誌論文] Cytotoxic effect of amide derivatives of trifluoromethionine a gainst the enteric protozoan parasite Entamoeba histolytica (2010)
  • 著者名/発表者名: Sato D, Kobayashi S, Yasui H, Shibata N, Toru T, Yamamoto M, Tokoro G, Ali V, Soga T, Takeuchi T, Suematsu M, Nozaki T.
  • 雑誌名: Int J Antimicrob Agents 35(1) ページ: 56-61
  • 査読あり
• [雑誌論文] Tubulointerstitial nephritis antigen-like 1 is expressed in extraembryonic tissues and interacts with laminin 1 in the reichert membrane at postimplantation in the mouse (2010)
  • 著者名/発表者名: Tajiri Y, Igarashi T, Li D, Mukai K, Suematsu M, Fukui E, Yoshizawa M, Matsumoto H.
  • 雑誌名: Biol Reprod 82(2) ページ: 263-270
  • 査読あり
• [雑誌論文] Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. (2009)
  • 著者名/発表者名: Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Endo J, Sano M, K
  • 雑誌名: Circ Res 105(11) ページ: 1118-1127
• [雑誌論文] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. (2009)
  • 著者名/発表者名: Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A
  • 雑誌名: Proc Natl Acad Sci U S A. 106 ページ: 17163-17168
• [雑誌論文] Measurement of Internal Body Time by Blood Metabolomics. (2009)
  • 著者名/発表者名: Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T., Ueda, H.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 106 ページ: 9890-9895
• [雑誌論文] Ligand-based gene expression profiling identifies critical role of glucocorticoid receptor in rat neonatal cardiomyocytes. (2009)
  • 著者名/発表者名: Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H
  • 雑誌名: Am J Physiol Endocrinol Metab 296(6)
• [雑誌論文] Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry. (2009)
  • 著者名/発表者名: Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., *Soga, T.
  • 雑誌名: Cancer Res 69 ページ: 4918-4925
• [雑誌論文] Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry. (2009)
  • 著者名/発表者名: Soga, T., Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.
  • 雑誌名: Anal. Chem 81 ページ: 6165-6174
• [雑誌論文] Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli. (2009)
  • 著者名/発表者名: Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., Soga, T., Tomita, M.
  • 雑誌名: J. Biol. Chem. 109 ページ: 16442-16451
• [雑誌論文] Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes. (2009)
  • 著者名/発表者名: Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., Uchida, K., Fujii, J.
  • 雑誌名: Biochem. J 422 ページ: 313-320
• [雑誌論文] HIF-1α is necessary to support gluconeogenesis during liver regeneration Biochem. Biophys. (2009)
  • 著者名/発表者名: Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R.S., Suematsu, M.
  • 雑誌名: Biochem. Biophys. Res. Commun. 387 ページ: 789-794
• [雑誌論文] Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis. (2009)
  • 著者名/発表者名: Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M., Handa, H.
  • 雑誌名: Toxicol. Sci 109 ページ: 143-151
• [雑誌論文] Cystathionine β-synthase as a Carbon Monoxide-sensitive Regulator of Bile Excretion. (2009)
  • 著者名/発表者名: Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakurakawa, T., Ishikawa, K., Goda, N., Yitagawa, Y., Kajiyama, M., Matsumoto, K., Suematsu, M.
  • 雑誌名: Hepatology 49 ページ: 141-150
• [雑誌論文] Rapid and reversible inhibition of aquaporin-4 by zinc (2009)
  • 著者名/発表者名: Yukutake Y, Hirano Y, Suematsu M, Yasui M.
  • 雑誌名: Biochemistry 48(51) ページ: 12059-12061
  • 査読あり
• [雑誌論文] Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart (2009)
  • 著者名/発表者名: Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K.
  • 雑誌名: Circ Res 105(11) ページ: 1118-27
  • 査読あり
• [雑誌論文] Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope (2009)
  • 著者名/発表者名: Harada T, Yuba-Kubo A, Sugiura Y, Zaima N, Hayasaka T, Goto-Inoue N, Wakui M, Suematsu M, Takeshita K, Ogawa K, Yoshida Y, Setou M.
  • 雑誌名: Analyt Chem 81(21) ページ: 9153-9157
  • 査読あり
• [雑誌論文] Ligand-based gene expression profiling reveals novel roles of glucoc orticoid receptor in cardiac metabolism (2009)
  • 著者名/発表者名: Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H.
  • 雑誌名: Am J Physiol Endocrinol Metab 296
  • 査読あり
• [雑誌論文] In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods (2009)
  • 著者名/発表者名: Nishino T, Yachie-Kinoshita A, Hirayama A, Soga T, Suematsu M, Tomita M.
  • 雑誌名: J Biotechnol 144(3) ページ: 212-223
  • 査読あり
• [雑誌論文] HIF-1α is necessary to support gluconeogenesis during liver regeneration (2009)
  • 著者名/発表者名: Tajima T, Goda N, Fujiki N, Hishiki T, Nishiyama Y, Senoo-Matsuda N, Shimazu M, Soga T, Yoshimura Y, Johnson RS, Suematsu M.
  • 雑誌名: Biochem Biophys Res Commun 387(4) ページ: 789-794
  • 査読あり
• [雑誌論文] Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in eryth rocytes (2009)
  • 著者名/発表者名: Iuchi Y, Okada F, Takamiya R, Kibe N, Tsunoda S, Nakajima O, Toyoda K, Nagae R, Suematsu M, Soga T, Uchida K, Fujii J.
  • 雑誌名: Biochem J 422(2) ページ: 313-320
  • 査読あり
• [雑誌論文] Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion (2009)
  • 著者名/発表者名: Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakuragawa, T., Ishikawa, K., Goda, N., Kitagawa, Y., Kajimura, M., Matsumoto, K., Suematsu, M.
  • 雑誌名: Hepatology 49 ページ: 141-150
  • 査読あり
• [雑誌論文] Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus (2009)
  • 著者名/発表者名: Kuramori, C., Azuma, M., Kume, K., Kaneko, Y., Inoue, A., Yamaguchi, Y., Kabe, Y., Hosoya, T., Kizaki, M., Suematsu, M., Handa, H.
  • 雑誌名: Biochem. Biophys. Res. Commun. (印刷中)
  • 査読あり
• [雑誌論文] Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis (2009)
  • 著者名/発表者名: Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanae, H., Kataoka, K., Suematsu. M., Handa, H.
  • 雑誌名: Toxicol. Sci. (印刷中)
  • 査読あり
• [雑誌論文] The effects of cilostazol on tissue oxygenation upon anischemic-reperfusion injury in the mouse cerebrum (2009)
  • 著者名/発表者名: Morikawa T., Hattori K., Kajimura M., Suematsu M
  • 雑誌名: Advances in Experimental Medicine and Biology (印刷中)
  • 査読あり
• [雑誌論文] Identification of Stem Cells During Prepubertal Spermatogenesis Via Monitoring of Nucleostemin Promoter Activity. (2008)
  • 著者名/発表者名: Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, *Hirao A
  • 雑誌名: Stem Cells 26 ページ: 3237-3246
• [雑誌論文] Exacerbating Role of γδ T Cells in Chronic Colitis of T Cell Receptor αMutant Mice. (2008)
  • 著者名/発表者名: Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Ueha, S., Matsushima, K., Suematsu, M., Mizoguchi, A., Hibi, T., Bhan, A.K., Ishikawa, H
  • 雑誌名: Gastroenterology 134 ページ: 481-490
• [雑誌論文] Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. (2008)
  • 著者名/発表者名: Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I
  • 雑誌名: Hum. Mol. Genet 17 ページ: 1994-2005
• [雑誌論文] Exacerbating role of γδ T cells in chronic colitis of T cell receptorα mutant mice (2008)
  • 著者名/発表者名: Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Uehara, S., Matsushima, K., Suematsu. M., Mizoguchi A., Hibi, T., Bhan, A. K., Ishikawa H.
  • 雑誌名: Gastroenterology 134 ページ: 481-490
  • 査読あり
• [雑誌論文] RORγt is dispensable for the development of intestinal mucosal T cells (2008)
  • 著者名/発表者名: Naito, T., Shiohara, T., Hibi, T., Suematsu. M., Ishikawa, H.
  • 雑誌名: Mucosal Immunology 1 ページ: 198-207
  • 査読あり
• [雑誌論文] Mercury chloride decreases the water permeability of aquapolin-4-reconstituted Droteoliposomes (2008)
  • 著者名/発表者名: Yukutake, Y., Tsuji, S., Hirano, Y., Adachi, T., Takahashi, T., Fuiihara, K., Agre, P., Yasui, M., Suematsu, M.
  • 雑誌名: Biol. Cell 100 ページ: 355-363
  • 査読あり
• [雑誌論文] Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocystinemia (2008)
  • 著者名/発表者名: Akahoshi, N., Kobayashi, C., Ishizaka, Y., Izumi, T., Himi, T., Suematsu, M., Ishii, I.
  • 雑誌名: Hum. Mol. Genet. 17 ページ: 1994-2005
  • 査読あり
• [雑誌論文] Cytochrome P-450_<17α>in β-cells of rat pancreas and its local steroidogenesis (2008)
  • 著者名/発表者名: Ogishima, T., Mitani, F., Suematsu. M.
  • 雑誌名: J. Steroid Biochem. Mol. Biol. 111 ページ: 80-86
  • 査読あり
• [雑誌論文] Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-sensitive genes by HEXIM1 (2008)
  • 著者名/発表者名: Shimizu, N., Yoshikawa, N. Wada, T., Handa, H., Sano, M., Fukuda, K., Suematsu, M., Sawai, T., Morimoto, C., Tanaka, H.
  • 雑誌名: Mol. Endocrinol. 22 ページ: 2609-2623
  • 査読あり
• [雑誌論文] α-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori. (2008)
  • 著者名/発表者名: Tsugawa, H., Suzuki, H., Nakagawa, I., Nishizawa, T., Saito, Y., Suematsu. M., Hibi, T.
  • 雑誌名: Biochem. Biophys. Res. Commun. 376 ページ: 46-51
  • 査読あり
• [雑誌論文] Establishment of a humanized model of liver using NOD/Shi-scid IL2R γ^<null> mice (2008)
  • 著者名/発表者名: Suemizu, H., Hasegawa, M., Kawai, K., Taniguchi, K., Monnai, M., Wakui, M., Suematsu. M., Ito, M., Peltz, G., Nakamura, M.
  • 雑誌名: Biochem. Biophys. Res. Commun. 377 ページ: 248-252
  • 査読あり
• [雑誌論文] Three-dimensional imaging of growing thrombus in vivo (2008)
  • 著者名/発表者名: Morikawa T., Kajimura M, Ichikawa M., Suematsu M.
  • 雑誌名: Microvascular Reviews and Communications 2 ページ: 8-12
  • NAID: 130004942918
  • 査読あり
• [雑誌論文] Exacerbating role of γδ T cells in chronic colitis T cell receptor α mutant mice. (2008)
  • 著者名/発表者名: Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Uehara, S., Matsushima, K., Suematsu, M., Mizoguchi, A., Hibi, T., Bhan, A. K., Ishikawa, H.
  • 雑誌名: Gastroenterology 134 ページ: 481-490
  • 査読あり
• [雑誌論文] Multiple Highthroughput Analyses Monitor The Response of E. coli to Perturbations" (2007)
  • 著者名/発表者名: Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., AraIshii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba
  • 雑誌名: Science 316 ページ: 593-597
• [雑誌論文] A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. (2007)
  • 著者名/発表者名: Shimokata K, Katayama Y, Murayama H, Suematsu M, Tsukihara T, Muramoto K, Yoshikawa S, Shimada H
  • 雑誌名: Proc Natl Acad Sci USA 104(10) ページ: 4200-4205
• [雑誌論文] Method for determination of association and dissociation rate constants of reversible biomolecular reactions by isothermal titration calorimeters. (2007)
  • 著者名/発表者名: Egawa, T., Tsuneshige, A., Suematsu, M., Yonetani, T
  • 雑誌名: Anal. Biochem 79(7) ページ: 2972-2978
• [雑誌論文] Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. (2007)
  • 著者名/発表者名: Hangai-Hoger, N., Tsai, A.G., Carbales, P., Suematsu, M., Intaglietta, M
  • 雑誌名: Crit Care Med 35(4) ページ: 1123-1132
• [雑誌論文] Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis. (2007)
  • 著者名/発表者名: Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., Suematsu, M.
  • 雑誌名: J Biol Chem 282(14) ページ: 10731-10741
• [雑誌論文] Menage-a-Trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. (2007)
  • 著者名/発表者名: Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD
  • 雑誌名: Cell Metab 5(2) ページ: 129-142
• [雑誌論文] Visualization of three-way comparisons of omics data. (2007)
  • 著者名/発表者名: Baran, R., Robert, M., Suematsu, M., Soga, T., Tomita, M.
  • 雑誌名: BMC Bioinformatics 8(1)
• [雑誌論文] Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioral characteristics. (2007)
  • 著者名/発表者名: Ishikawa H, Naito T, Iwanaga T, Takahashi-Iwanaga H, Suematsu M, Hibi T, Nanno M
  • 雑誌名: Immunol Rev 215 ページ: 154-165
• [雑誌論文] Regulation of reactive oxygen species by atm is essential for proper response to DNA double-strand breaks in lymphocytes. (2007)
  • 著者名/発表者名: Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A
  • 雑誌名: J Immunol 178 ページ: 103-110
• [雑誌論文] Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioral characteristics. (2007)
  • 著者名/発表者名: Ishikawa, H., Naito, T., Iwanaga, T., Takahashi-Iwanaga, H., Suematsu, M., Hibi, T., Nanno, M.
  • 雑誌名: Immunol. Rev. 215 ページ: 154-165
  • 査読あり
• [雑誌論文] Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis. (2007)
  • 著者名/発表者名: Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., Suematsu, M.
  • 雑誌名: J. Biol. Chem. 14 ページ: 10731-10741
  • 査読あり
• [雑誌論文] A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. (2007)
  • 著者名/発表者名: Shimokata, K., Katayama, Y., Murayama, H., Suematsu, M., Tsukihara, T., Muramoto, K., Yoshikawa, S., Shimada, H.
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 10 ページ: 4200-4205
  • 査読あり
• [雑誌論文] Method for determination of association and dissociation rate constants of reversible biomolecular reactions by isothermal titration calorimeters. (2007)
  • 著者名/発表者名: Egawa, T., Tsuneshige, A., Suematsu. M., Yonetani, T.
  • 雑誌名: Anal. Biochem. 7 ページ: 2972-2978
  • 査読あり
• [雑誌論文] Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. (2007)
  • 著者名/発表者名: Hangai-Hoger, N., Tsai, A. G., Carbales, P., Suematsu, M., Intaglietta, M.
  • 雑誌名: Crit. Care Med 4 ページ: 1123-1132
  • 査読あり
• [雑誌論文] Visualization of three-way comparisons of omics data. (2007)
  • 著者名/発表者名: Baran, R., Robert, M., Suematsu, M., Soga, T., Tomita, M.
  • 雑誌名: BMC Bioinformatics 1 ページ: 72-72
  • 査読あり
• [雑誌論文] Targeting NAD(P)H oxidase: Ets-1 regulates p47^<phox> expression. (2007)
  • 著者名/発表者名: Adachi, T., Yamamoto, M., Suematsu, M.
  • 雑誌名: Circ. Res. 101 ページ: 962-964
  • 査読あり
• [雑誌論文] Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes : simulation and its verification by metabolome analysis (2007)
  • 著者名/発表者名: Kinoshita A, Tsukada K, Soga T, Hishiki T, et al.
  • 雑誌名: The Journal of Biological Chemistry 282(14) ページ: 10731-10741
• [雑誌論文] A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. (2007)
  • 著者名/発表者名: Shimokata K, Katayama Y, Murayama H, Suematsu M, et al.
  • 雑誌名: Proceedings of National Academy of Sciences USA 104(10) ページ: 4200-4205
• [雑誌論文] Method for determination of association and dissociation rate constants of reversible biomolecular reactions by isothermal titration calorimeters. (2007)
  • 著者名/発表者名: Egawa T, Tsuneshige A, Suematsu, M, Yonetani T
  • 雑誌名: Analytical Biochemistry 79(7) ページ: 2972-2978
• [雑誌論文] MathDAMP: a package for differential analysis of metabolite profiles. (2006)
  • 著者名/発表者名: Baran, R., Kochi, H., Saito, N., Suematsu, M., Soga, T., Nishioka, T., Robert, M., Tomita, M.
  • 雑誌名: BMC Bioinformatics 7
• [雑誌論文] Design of metal cofactors activated by a protein-protein electron transfer system. (2006)
  • 著者名/発表者名: Ueno T, Yokoi N, Unno M, Matsui T, Tokita M, Yamada M, Ikeda-Saito M, Nakajima H, Watanabe Y
  • 雑誌名: Proc Natl Acad Sci USA 103, 14 ページ: 9416-9421
• [雑誌論文] Compound I of heme oxygenase cannot hydroxylate its heme meso-carbon J. Am. (2006)
  • 著者名/発表者名: Matsui T, Kim SH, Jin H, Hoffman BM, Ikeda-Saito M
  • 雑誌名: J. Am. Chem. Soc 128 ページ: 1090-1091
• [雑誌論文] T-state stabilization of hemoglobin allostery by nitric oxide: a protection against post-ischemic hepatobiliary dysfunction. (2006)
  • 著者名/発表者名: Suganuma K, Tsukada K, Tsuneshige A, Kashiba M, Yonetani T, Suematsu M
  • 雑誌名: Antioxid Redox Signal 8 ページ: 1847-1855
• [雑誌論文] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. (2006)
  • 著者名/発表者名: Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakuragawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka, T., Tomita, M.
  • 雑誌名: J Biol Chem 281(24) ページ: 16768-16776
• [雑誌論文] Maintaining the redox balance intact: gosha-jinki-gan but not insulin activates guanylate cyclase in diabetic rats. (2006)
  • 著者名/発表者名: Cameron-Scaefer S, Kondo K, Ishige A, Tsuyama S, Uchida K, Hanawa T, Suematsu M, Watanabe K.
  • 雑誌名: Ophthalmic Res 38(2) ページ: 95-104
• [雑誌論文] Various adhesion molecules impair microvascular leukocyte kinetics in ventilator-induced lung injury. (2006)
  • 著者名/発表者名: Miyao N, Suzuki Y, Takeshita K, Kudo H, Ishii M, Hiraoka R, Nishio K, Tamatani T, Sakamoto S, Suematsu M, Tsumura H, Ishizaka A, Yamaguchi K
  • 雑誌名: Am J Physiol Lung Cell Mol Physiol 290
• [雑誌論文] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. (2006)
  • 著者名/発表者名: Soga T, Baran R, Suematsu M, et al.
  • 雑誌名: The Journal of Biological Chemistry 281(24) ページ: 16768-16776
• [雑誌論文] T-state stabilization of hemoglobin allostery by nitric oxide : a protection against post-ischemic hepatobiliary dysfunction. (2006)
  • 著者名/発表者名: Suganuma K, Tsukada K, et al.
  • 雑誌名: Antioxidants and Redox Signaling 8(9-10) ページ: 1847-1855
• [雑誌論文] MathDAMP : A package for differential analysis of metabolomic profiles. (2006)
  • 著者名/発表者名: Baran R, Kochi H, Saito N, Suematsu M, et al.
  • 雑誌名: BMC Bioinformatics 7
• [雑誌論文] S-glutathiolation by peroxynitrite of p21Ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. (2006)
  • 著者名/発表者名: Clavreul N, Adachi T, Pimentel DR, et al.
  • 雑誌名: FASEB Journal (in press)
• [雑誌論文] T-state stabilization of hemoglobin allostery by nitric oxide : A protection against post-ischemic hepatobiliary dysfunction (2006)
  • 著者名/発表者名: Suganuma K, Tsukada K, Tsuneshige A, Kashiba M, Yonetani T, Suematsu M.
  • 雑誌名: Antioxidants and Redox Signaling (in press)
• [雑誌論文] O2-and H2O2-dependent verdoheme degradation by heme oxygenase: Reaction mechanisms and potential physiological roles of the dual pathway degradation J (2005)
  • 著者名/発表者名: Matsui T, Nakajima A, Fujii H, Mansfield K, Matera C. Migita T, Yoshida T, Ikeda-Saito M.
  • 雑誌名: Biol Chem 280 ページ: 36833-40
• [雑誌論文] Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of??-ketoglutarate decarboxylase. (2005)
  • 著者名/発表者名: Tian J, Bryk R, Itoh M, Suematsu, M, Nathan C
  • 雑誌名: Proc Natl Acad Sci USA 102 ページ: 10670-10675
• [雑誌論文] Carbon monoxide from heme oxygenase-2 is a tonic regulator against nitric oxide-dependent vasodilatation in the adult rat cerebral microcirculation. (2005)
  • 著者名/発表者名: Ishikawa M, Kajimura M, Adachi T, Maruyama K, Makino N, Goda N, Yamaguchi T, Sekizuka E, Suematsu M
  • 雑誌名: Circ Res 97(12)
• [雑誌論文] Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver. (2005)
  • 著者名/発表者名: Fujii K, Sakuragawa T, Kashiba M, Sugiura Y, Maruyama K, Goda N, Nimura Y, Suematsu M
  • 雑誌名: Antioxid Redox Signal 7(5-6) ページ: 788-794
• [雑誌論文] Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes. (2005)
  • 著者名/発表者名: Sugiura, Y., Kashiba, M., Hoshikawa, K., Sasaki, R., Saito, K., Kimura, H., Maruyama, K., Goda, N., Suematsu M.
  • 雑誌名: Antioxid. Redox Signal 7(5-6) ページ: 781-787
• [雑誌論文] Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver. (2005)
  • 著者名/発表者名: Fujii K, Sakuragawa T, Kashiba M, Sugiura Y, Maruyama K, et al.
  • 雑誌名: Antioxidants and Redox Signaling 7(5-6) ページ: 781-787
• [雑誌論文] Variant tricarboxylic acid cycle in Mycobacterium tuberculosis : Identification of α-ketoglutarate decarboxylase. (2005)
  • 著者名/発表者名: Tian J, Bryk R, Itoh M, Suematsu M, Nathan C
  • 雑誌名: Proceedings of National Academy of Sciences USA 102 ページ: 10670-10675
• [雑誌論文] Carbon monoxide as a guardian against hepatobiliary dysfunction (2005)
  • 著者名/発表者名: Suematsu M, Tsukada K, Tajima T, Yamamoto T, Ichiai D, et al.
  • 雑誌名: Alcoholism Clinical and Experimental Researches 29(11)
• [雑誌論文] Carbon monoxide from heme oxygenase-2 is a tonic regulator against nitric oxide-dependent vasodilation in the adult rat cerebral microcirculation (2005)
  • 著者名/発表者名: Ishikawa M, Kajimura M, Adachi T, Maruyama K, Makino N, Suematsu M
  • 雑誌名: Circulation Research 97(12)
• [学会発表] ガス分子による生体制御機構の系統的探索と医学応用 (2010)
  • 著者名/発表者名: 末松誠
  • 学会等名: 獣医生化学会シンポジウム
  • 発表場所: 日本獣医生命科学大学
  • 年月日: 2010-03-28
• [学会発表] ガス分子による生体制御機構の系統的探索と医学応用:質量分析技術によるブレイクスル (2010)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第26回臨床フリーラジカル会議「再考-臨床フリーラジカル学」
  • 発表場所: 琵琶湖ホテル
  • 年月日: 2010-01-30
• [学会発表] ガス分子による臓器微小循環制御機構の系統的探索と医学応用 (2009)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第37回日本潰瘍学会 特別講演
  • 発表場所: 北里大学薬学部コンベンションホール
  • 年月日: 2009-11-07
• [学会発表] Cystathionine β-synthase accounts for the CO-responsive sensor regulating organ function : mining through metabolome (2009)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸国際会議場
  • 年月日: 2009-10-23
• [学会発表] ガス分子による代謝システム制御機構の系統的探索と医学応用 (2009)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第21回ゲノム創薬フォーラム
  • 発表場所: 日本薬学会・長井記念ホール
  • 年月日: 2009-06-15
• [学会発表] CO-MEDIATED MODULATION OF H2S GENERATION VIA CBS : APUTATIVE TONIC MECHANISM FOR NEUROVASCULAR UNITS (2009)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第10回血管拡張機序に関する国際シンポジウム ランチョンセミナー
  • 発表場所: ホテル松島 大観荘
  • 年月日: 2009-06-03
• [学会発表] 質量分析技術を利用したガス分子によるエネルギー代謝制御機構の系統的探索 (2009)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第52回日本糖尿病学会年次学術集会 Meet the Expert 1
  • 発表場所: 大阪国際会議場
  • 年月日: 2009-05-22
• [学会発表] ガス分子による生体制御機構の系統的探索と医学応用 (2009)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第57回循環力学研究会
  • 発表場所: 興和株式会社
  • 年月日: 2009-05-16
• [学会発表] HIF-1 is necessary for coordinated control of gluconeogenesis during liver regeneration (2008)
  • 著者名/発表者名: 末松誠
  • 学会等名: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会BMB2008
  • 発表場所: 神戸、日本
  • 年月日: 2008-12-11
• [学会発表] Biomedical application of metabolome analysis: Systematic molecular mining for gaseous signal transducers (2008)
  • 著者名/発表者名: Suematsu Makoto
  • 学会等名: ISOTT2008 (Infernational Society on Oxygen Transport to Tissue 2008), Special lecture
  • 発表場所: 札幌、日本
  • 年月日: 2008-08-06
• [学会発表] HIF-1 as a regulator of stress-induced adaptation of parenchymal and nonparenchymal cells in the liver (2008)
  • 著者名/発表者名: Suematsu Makoto
  • 学会等名: 3rd International Symposium on ALPD and Cirrhosis, Special lecture
  • 発表場所: Bilbao, Spain
  • 年月日: 2008-07-18
• [学会発表] Biomedical application of metabolome analysis (2008)
  • 著者名/発表者名: Suematsu M
  • 学会等名: 37th Congress of Society for Critical Care Medicine
  • 発表場所: ホノルル 米国
  • 年月日: 2008-02-04
• [学会発表] Biomedical application of metabolome analysis to mine gaseous signal transducers in the liver (2007)
  • 著者名/発表者名: Suematsu M
  • 学会等名: APS Symposium: Frontiers in the Cellular and Molecular Physiology of the Hepatic Microcirculation. for EB2007
  • 発表場所: Invited Lecture. Washington DC
  • 年月日: 2007-04-29
• [学会発表] Biomedical application of metabolome analysis (2006)
  • 著者名/発表者名: Suematsu M
  • 学会等名: Harvard-Kitasato Symposium for Critical Path for Translational Research
  • 発表場所: Tokyo(Invited Lecture)
  • 年月日: 2006-10-24
• [学会発表] Metabolome analyses reveal roles of cystathionine beta synthase as a CO-responsive metabolic regulator in mammals (2006)
  • 著者名/発表者名: Suematsu M
  • 学会等名: In NO and CO: distinct biological properties. The 20th IUBMB Symposium
  • 発表場所: Organizer, Kyoto
• [学会発表] Carbon monoxide as a guardian against the liver injury (2005)
  • 著者名/発表者名: Suematsu M
  • 学会等名: Plenary Lecture
  • 発表場所: ISBRA Satellite Symposium
  • 年月日: 2005-09-02
• [学会発表] Erythrocytes as an oxygen-sensing metabomic sink determining microvascular tone (2005)
  • 学会等名: IUPS Plenary Symposium
  • 発表場所: San Diego CA
• [図書] メタボローム解析技術による新しい代謝制御機構の系統的探索 細胞工学特集 (2006)
  • 著者名/発表者名: 末松 誠, 菱木貴子, 岩渕卓也, 他
  • 総ページ数: 110
  • 出版者: 秀潤社
• [図書] 細胞学 vol 25(2) 161-165 (2006)
  • 著者名/発表者名: 末松 誠, 梶村真弓, 足立 健
  • 出版者: ヘムオキシゲナーゼ-CO系による血管機能制御機構とNOシステムとの相互作用
• [産業財産権] ^<15>O_2で標識したヘモグロビンを含む生体組織検査薬及びその製造方法 (2005)
  • 発明者名: 藤林靖久, 末松 誠
  • 権利者名: (株)オキシジェニクス
  • 出願年月日: 2005-11-18