| 研究実績の概要 |
To examine the disuse osteoporosis, tail suspension was used for an animal model for unloading. In physiological condition, the bone volume of Fkbp5-/- mice was similar to that of wild-type mice. After tail suspension, bone loss was more severe in Fkbp5-/- mice than wild-type mice in micro-CT analyses.
To examine GC-induced osteoporosis, implantation of prednisolone or injection of Dex was performed in wild-type and Fkbp5-/- mice. The GC treatment reduced cortical bone volume and bone formation more severely in Fkbp5-/- mice than wild-type mice. These finding indicated that Fkbp5 inhibits bone loss in unloading and GC treatment.
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