Novel adjuvant method of malignant brain tumor neutron capture therapy with absorbed dose evaluation and tumor localization using composite boron and high-Z element nanoparticles.

• 研究課題/領域番号: 17K15797
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 医学物理学・放射線技術学
• 研究機関: 筑波大学
• 研究代表者: ザボロノク アレクサンドル 筑波大学, 医学医療系, 助教 (20723117)
• 研究期間 (年度): 2017-04-01 – 2019-03-31
• 研究課題ステータス: 完了 (2018年度)
• 配分額: 2,990千円 (直接経費: 2,300千円、間接経費: 690千円); 2018年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2017年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
• キーワード: glioma / nanoparticles / radiotherapy / radiodiagnosis / BNCT / boron / high-Z element

研究成果の概要

我々は、ホウ素ナノ粒子を、微粒子のカスケード超音波分散／破壊によって合成した。加速器中性子源の有効性を、ヒトおよび動物細胞株を用いて証明した。ホウ素に関連した吸収線量計算方法を試験し、独特の公式を開発した。薬物送達システムは標的ホウ素化合物の開発に極めて重要であるため、動物実験においてリポソーム送達を標準的な低分子量ホウ素化合物と比較した。 我々の方法は、加速器ホウ素中性子捕捉療法においてホウ素と高Z元素の組み合わせを用いることによって吸収線量を決定することを可能するので、将来的に我々のホウ素線量推定方法の将来の実施は、シンチグラフィーまたは同位体スキャンを通して実現することが可能となる。

研究成果の学術的意義や社会的意義

In Japan, cancer is one of major reasons for morbidity and mortality, and the number of patients with malignant tumors is increasing year after year. The development of new forms of boron agents will move forward BNCT research and its future clinical application to extend life of cacner patients.

研究成果

• [雑誌論文] Polycomplexes of Hyaluronic Acid and Borates in a Solid State and Solution: Synthesis, Characterization and Perspectives of Application in Boron Neutron Capture Therapy (2018)
  • 著者名/発表者名: Zelenetskii Alexander、Uspenskii Sergey、Zaboronok Alexander、Cherkaev Georgij、Shchegolihin Alexander、Mathis Bryan、Selyanin Mikhail、Yamamoto Tetsuya、Matsumura Akira
  • 雑誌名: Polymers 巻: 10 号: 2 ページ: 181-181
  • DOI: 10.3390/polym10020181
  • NAID: 120007134320
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy (2017)
  • 著者名/発表者名: Sato Eisuke、Zaboronok Alexander、Yamamoto Tetsuya、Nakai Kei、Taskaev Sergey、Volkova Olga、Mechetina Ludmila、Taranin Alexander、Kanygin Vladimir、Isobe Tomonori、Mathis Bryan J、Matsumura Akira
  • 雑誌名: Journal of Radiation Research 巻: 59 号: 2 ページ: 101-107
  • DOI: 10.1093/jrr/rrx071
  • NAID: 120007134126
  • 査読あり / オープンアクセス / 国際共著
• [学会発表] Boron Neutron Capture Therapy: Current State and Future Perspectives (2019)
  • 著者名/発表者名: Alexander Zaboronok
  • 学会等名: International Stereotactic Radiosurgery Society Webinar
  • 国際学会 / 招待講演
• [学会発表] Hybrid gold and boron nanoparticles for treatment and boron dose estimation in boron neutron capture therapy for malignant glioma. (2018)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Kanygin V, Bykov T, Kasatov D, Kolesnikov I, Koshkarev A, Makarov A, Shchudlo I, Volkova O, Mechetina L, Taranin A, Kasatova A, Kichigin A, Uspenskii S, Kaptakhanova P, Zelenetskii A, Selyanin M, Bekarevich R, Mitsuishi K, Sato E, Nakai K, Tsurubuchi T, Yoshida F, Ishikawa E, Mathis BJ, et al.
  • 学会等名: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
  • 国際学会
• [学会発表] Radiobiological in vitro and in vivo investigations on accelerator neutron source in Budker Institute of Nuclear Physics. (2018)
  • 著者名/発表者名: Kanygin V, Kichigin A, Zaboronok A, Taskaev S, Kasatova A, Zavyalov E, Akulov A, Razumov I
  • 学会等名: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
  • 国際学会
• [学会発表] Difference in BPA uptake between glioma stem cells and their cancerous cells. (2018)
  • 著者名/発表者名: Yoshida F, Kurita T, Endo K, Nakai K, Shirakawa M, Zaboronok A, Ishikawa E, Matsumura A
  • 学会等名: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
  • 国際学会
• [学会発表] Japan-Russia collaborative research on accelerator-based boron neutron capture therapy for malignant glioma. (2018)
  • 著者名/発表者名: Zaboronok A, KanyginV, Taskaev S, Bykov T, Kasatov D, Kolesnikov J, Koshkarev A, Makarov A, Shchudlo I, Volkova O, Mechetina L, Taranin A, Kasatova A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Zavjalov E, Akulov A, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A
  • 学会等名: The 6th Japan Russia Neurosurgical Symposium
  • 国際学会
• [学会発表] Boron neutron capture therapy for malignant brain tumors: current situation in the world, our experience in Russia and Japan, and further development perspectives. (2018)
  • 著者名/発表者名: Zaboronok A, Ishikawa E, Taskaev S, Bykov T, Kasatov D, Kolesnikov I, Koshkarev A, Makarov I, Shchudlo I, Volkova O, Mechetina L, Taranin A, Zavjalov E, Akulov A, Kanygin V, Kasatova A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Mathis BJ, Yamamoto T, Matsumura A
  • 学会等名: The 2nd Congress of Neurosurgeons of Uzbekistan
• [学会発表] Accelerator-based boron neutron capture therapy for malignant glioma using composite boron-gold nanoparticles: preclinical evaluation. (2018)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Zelenetskii A, Uspenskii S, Khaptakhanova P, Ishikawa E, Nakai K, Yamamoto T, Mathis BJ, Tsurubuchi T, Matsumura A.
  • 学会等名: The 77th Annual Meeting of the Japan Neurosurgical Society
• [学会発表] Boron nanoparticles production by ultrasonic cavitation. (2018)
  • 著者名/発表者名: Uspenskii S, Khaptakhanova P, Kurkin T, Zaboronok A, Zelenetskii A, Selyanin M, Taskaev S.
  • 学会等名: The V International Conference Fundamental Bases of Mechanochemical Technologies
  • 国際学会
• [学会発表] Current state and vision of Boron neutron capture therapy (BNCT). Invited lecture. (2018)
  • 著者名/発表者名: Zaboronok A
  • 学会等名: Japan-Russia Joint Symposium on Education and Scientific Development in Medicine 2018
  • 国際学会 / 招待講演
• [学会発表] Boron neutron capture therapy for malignant glioma: our experience, present status and future perspectives. (2018)
  • 著者名/発表者名: Zaboronok AA, Kanygin VV, Taskaev SYu, Volkova OYu, Mechetina LV, Taranin AV, Zavjalov EL, Akulov AE, Kasatova AI, Kichigin AI, Byvaltsev VA, Sato E, Nakai K, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A
  • 学会等名: The II Siberian Neurosurgical Congress
• [学会発表] Accelerator-based neutron capture therapy: pre-clinical evaluation and prospective clinical use. (2017)
  • 著者名/発表者名: Zaboronok A, Kanygin V, Taskaev S, Volkova O, Mechetina L, Taranin A, Iarullina A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A.
  • 学会等名: International Conference “Physics of Cancer: Interdisciplinary Problems and Clinical Applications”, Tomsk, Russian Federation, 2017.5.23-26
  • 国際学会 / 招待講演
• [学会発表] Accelerator-based neutron capture therapy for malignant glioma with in-sample dosimetry using gold nanoparticles (2017)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Kanygin V, Kasatov D, Makarov A, Volkova O, Mechetina L, Taranin A, Iarullina A, Nakai K, Sato E, Mathis BJ, Yamamoto T, Matsumura A.
  • 学会等名: The 32nd Japan Neurosurgery English Forum, Saitama, Japan, 2017.7.14.
• [学会発表] Perspectives of combined photodynamic diagnosis and accelerator-based neutron capture therapy of malignant glioma using photosensitizer- and 10B-containing liposomes. (2017)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Muhamadiyarov R, Kichigin A, Volkova O, Mechetina L, Sato E, Nakai K, Yamamoto T, Taranin A, Kanygin V, Mathis BJ, Matsumura A.
  • 学会等名: 17th Annual Congress of the Korean Photodynamic Association. Seoul National University Bundang Hospital, Healthcare Innovation Park. Seoul, South Korea. 2017.09.02.
  • 国際学会
• [学会発表] Perspectives of a photosensitizer and 10B compound liposomal delivery for combined photodynamic diagnosis/therapy and accelerator-based neutron capture therapy for malignant gliomas. (2017)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Volkova O, Mechetina L, Kichigin A, Sato E, Nakai K, Yamamoto T, Taranin A, Kanygin V, Mathis BJ, Matsumura A.
  • 学会等名: 9th Young Researchers’ BNCT Meeting. Kyoto University Uji Obaku Plaza, Gokasho, Uji, Kyoto, Japan. 2017.11.13-15.
  • 国際学会
• [学会発表] Boron neutron capture therapy for malignant glioma: our experience at the reactor and preclinical evaluation of an accelerator-based neutron source. (2017)
  • 著者名/発表者名: Zaboronok AA, KanyginVV, Taskaev SYu, Volkova OYu, Mechetina LV, Taranin AV, Iarullina AI, Kichigin AI, Byvaltsev VA, Sato E, Nakai K, Zavjalov EL, Akulov AE, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A.
  • 学会等名: I Congress of Eurasian Association of Pediatric Neurosurgeons. Minsk, Belarus. 2017.11.29-12.01.
  • 国際学会
• [備考] Webinar on BNCT by Alexander Zaboronok
  • URL: http://isrsy.org/public/en/courses/webinars/past/