Novel adjuvant method of malignant brain tumor neutron capture therapy with absorbed dose evaluation and tumor localization using composite boron and high-Z element nanoparticles.

• 研究課題/領域番号: 17K15797
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 医学物理学・放射線技術学
• 研究機関: 筑波大学
• 研究代表者: ザボロノク アレクサンドル 筑波大学, 医学医療系, 助教 (20723117)
• 研究期間 (年度): 2017-04-01 – 2019-03-31
• 研究課題ステータス: 完了 (2018年度)
• 配分額: 2,990千円 (直接経費: 2,300千円、間接経費: 690千円); 2018年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2017年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
• キーワード: BNCT / glioma / nanoparticles / boron / high-Z element

研究実績の概要

In the 2018 fiscal year, following stages of the main plan were accomplished. The synthesis of the composite nanoparticles was continued and boron nanoparticles were successful synthesized. As the stability of the compounds during high-Z element consolidation differed in the experiments, in vivo application was delayed. Animal tumor model using F98 rat glioma cells and Fisher rats was created. Accumulation of nanoparticles in animal tumor models was evaluated, though was below the expected values. The focus of experiments was shifted to drug delivery system including nanoparticle surface modifications and liposomal delivery of boron compounds. The results of the study were presented at several conferences and will be included in scientific publications.

研究成果

• [雑誌論文] Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. (2018)
  • 著者名/発表者名: Sato Eisuke、Zaboronok Alexander、Yamamoto Tetsuya、Nakai Kei、Taskaev Sergey、Volkova Olga、Mechetina Ludmila、Taranin Alexander、Kanygin Vladimir、Isobe Tomonori、Mathis Bryan J、Matsumura Akira
  • 雑誌名: Journal of Radiation Research 巻: 59 ページ: 101-107
  • DOI: 10.1093/jrr/rrx071
  • NAID: 120006478280
  • 査読あり / オープンアクセスとしている / 国際共著/国際学会である
• [雑誌論文] Polycomplexes of Hyaluronic Acid and Borates in a Solid State and Solution: Synthesis, (2018)
  • 著者名/発表者名: Zelenetskii Alexander、Uspenskii Sergey、Zaboronok Alexander、Cherkaev Georgij、Shchegolihin Alexander、Mathis Bryan、Selyanin Mikhail、Yamamoto Tetsuya、Matsumura Akira
  • 雑誌名: Polymers (Basel) 巻: 10 ページ: 101-107
  • DOI: 10.3390/polym10020181
  • 査読あり / オープンアクセスとしている / 国際共著/国際学会である
• [学会発表] Boron Neutron Capture Therapy: Current State and Future Perspectives (2019)
  • 著者名/発表者名: Alexander Zaboronok
  • 学会等名: International Stereotactic Radiosurgery Society Webinar
  • 国際共著/国際学会である / 招待講演
• [学会発表] Hybrid gold and boron nanoparticles for treatment and boron dose estimation in boron neutron capture therapy for malignant glioma. (2018)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Kanygin V, Bykov T, Kasatov D, Kolesnikov I, Koshkarev A, Makarov A, Shchudlo I, Volkova O, Mechetina L, Taranin A, Kasatova A, Kichigin A, Uspenskii S, Kaptakhanova P, Zelenetskii A, Selyanin M, Bekarevich R, Mitsuishi K, Sato E, Nakai K, Tsurubuchi T, Yoshida F, Ishikawa E, Mathis BJ, et al.
  • 学会等名: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
  • 国際共著/国際学会である
• [学会発表] Radiobiological in vitro and in vivo investigations on accelerator neutron source in Budker Institute of Nuclear Physics. (2018)
  • 著者名/発表者名: Kanygin V, Kichigin A, Zaboronok A, Taskaev S, Kasatova A, Zavyalov E, Akulov A, Razumov I
  • 学会等名: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
  • 国際共著/国際学会である
• [学会発表] Difference in BPA uptake between glioma stem cells and their cancerous cells. (2018)
  • 著者名/発表者名: Yoshida F, Kurita T, Endo K, Nakai K, Shirakawa M, Zaboronok A, Ishikawa E, Matsumura A
  • 学会等名: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
  • 国際共著/国際学会である
• [学会発表] Japan-Russia collaborative research on accelerator-based boron neutron capture therapy for malignant glioma. (2018)
  • 著者名/発表者名: Zaboronok A, KanyginV, Taskaev S, Bykov T, Kasatov D, Kolesnikov J, Koshkarev A, Makarov A, Shchudlo I, Volkova O, Mechetina L, Taranin A, Kasatova A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Zavjalov E, Akulov A, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A
  • 学会等名: The 6th Japan Russia Neurosurgical Symposium
  • 国際共著/国際学会である
• [学会発表] Boron neutron capture therapy for malignant brain tumors: current situation in the world, our experience in Russia and Japan, and further development perspectives. (2018)
  • 著者名/発表者名: Zaboronok A, Ishikawa E, Taskaev S, Bykov T, Kasatov D, Kolesnikov I, Koshkarev A, Makarov I, Shchudlo I, Volkova O, Mechetina L, Taranin A, Zavjalov E, Akulov A, Kanygin V, Kasatova A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Mathis BJ, Yamamoto T, Matsumura A
  • 学会等名: The 2nd Congress of Neurosurgeons of Uzbekistan
• [学会発表] Accelerator-based boron neutron capture therapy for malignant glioma using composite boron-gold nanoparticles: preclinical evaluation. (2018)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Zelenetskii A, Uspenskii S, Khaptakhanova P, Ishikawa E, Nakai K, Yamamoto T, Mathis BJ, Tsurubuchi T, Matsumura A.
  • 学会等名: The 77th Annual Meeting of the Japan Neurosurgical Society
• [学会発表] Boron nanoparticles production by ultrasonic cavitation. (2018)
  • 著者名/発表者名: Uspenskii S, Khaptakhanova P, Kurkin T, Zaboronok A, Zelenetskii A, Selyanin M, Taskaev S.
  • 学会等名: The V International Conference Fundamental Bases of Mechanochemical Technologies
  • 国際共著/国際学会である
• [学会発表] Current state and vision of Boron neutron capture therapy (BNCT). Invited lecture. (2018)
  • 著者名/発表者名: Zaboronok A
  • 学会等名: Japan-Russia Joint Symposium on Education and Scientific Development in Medicine 2018
  • 国際共著/国際学会である / 招待講演
• [学会発表] Boron neutron capture therapy for malignant glioma: our experience, present status and future perspectives. (2018)
  • 著者名/発表者名: Zaboronok AA, Kanygin VV, Taskaev SYu, Volkova OYu, Mechetina LV, Taranin AV, Zavjalov EL, Akulov AE, Kasatova AI, Kichigin AI, Byvaltsev VA, Sato E, Nakai K, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A
  • 学会等名: The II Siberian Neurosurgical Congress
• [学会発表] Accelerator-based neutron capture therapy: pre-clinical evaluation and prospective clinical use. (2017)
  • 著者名/発表者名: Zaboronok A, Kanygin V, Taskaev S, Volkova O, Mechetina L, Taranin A, Iarullina A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A.
  • 学会等名: International Conference “Physics of Cancer: Interdisciplinary Problems and Clinical Applications”, Tomsk, Russian Federation, 2017.5.23-26
  • 国際共著/国際学会である / 招待講演
• [学会発表] Accelerator-based neutron capture therapy for malignant glioma with in-sample dosimetry using gold nanoparticles (2017)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Kanygin V, Kasatov D, Makarov A, Volkova O, Mechetina L, Taranin A, Iarullina A, Nakai K, Sato E, Mathis BJ, Yamamoto T, Matsumura A.
  • 学会等名: The 32nd Japan Neurosurgery English Forum, Saitama, Japan, 2017.7.14.
• [学会発表] Perspectives of combined photodynamic diagnosis and accelerator-based neutron capture therapy of malignant glioma using photosensitizer- and 10B-containing liposomes. (2017)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Muhamadiyarov R, Kichigin A, Volkova O, Mechetina L, Sato E, Nakai K, Yamamoto T, Taranin A, Kanygin V, Mathis BJ, Matsumura A.
  • 学会等名: 17th Annual Congress of the Korean Photodynamic Association. Seoul National University Bundang Hospital, Healthcare Innovation Park. Seoul, South Korea. 2017.09.02.
  • 国際共著/国際学会である
• [学会発表] Perspectives of a photosensitizer and 10B compound liposomal delivery for combined photodynamic diagnosis/therapy and accelerator-based neutron capture therapy for malignant gliomas. (2017)
  • 著者名/発表者名: Zaboronok A, Taskaev S, Volkova O, Mechetina L, Kichigin A, Sato E, Nakai K, Yamamoto T, Taranin A, Kanygin V, Mathis BJ, Matsumura A.
  • 学会等名: 9th Young Researchers’ BNCT Meeting. Kyoto University Uji Obaku Plaza, Gokasho, Uji, Kyoto, Japan. 2017.11.13-15.
  • 国際共著/国際学会である
• [学会発表] Boron neutron capture therapy for malignant glioma: our experience at the reactor and preclinical evaluation of an accelerator-based neutron source. (2017)
  • 著者名/発表者名: Zaboronok AA, KanyginVV, Taskaev SYu, Volkova OYu, Mechetina LV, Taranin AV, Iarullina AI, Kichigin AI, Byvaltsev VA, Sato E, Nakai K, Zavjalov EL, Akulov AE, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A.
  • 学会等名: I Congress of Eurasian Association of Pediatric Neurosurgeons. Minsk, Belarus. 2017.11.29-12.01.
  • 国際共著/国際学会である
• [備考] Webinar on BNCT by Alexander Zaboronok
  • URL: http://isrsy.org/public/en/courses/webinars/past/