過栄養状態における肝臓機能の破綻と生活習慣病の研究

• 研究課題/領域番号: 18109008
• 研究種目: 基盤研究(S)
• 配分区分: 補助金
• 研究分野: 消化器内科学
• 研究機関: 金沢大学
• 研究代表者: 金子 周一 金沢大学, 医学系, 教授 (60185923)
• 研究分担者: 中沼 安二 金沢大学, 医学系, 教授 (10115256) ; 本多 政夫 金沢大学, 医学系研究科, 教授 (00272980) ; 篁 俊成 金沢大学, 医学系研究科, 准教授 (00324111) ; 中本 安成 金沢大学, 医学部附属病院, 講師 (40293352)
• 連携研究者: 本多 政夫 金沢大学, 保健学系, 教授 (00272980) ; 篁 俊成 金沢大学, 医学系, 准教授 (00324111)
• 研究期間 (年度): 2006 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 100,620千円 (直接経費: 77,400千円、間接経費: 23,220千円); 2010年度: 11,050千円 (直接経費: 8,500千円、間接経費: 2,550千円); 2009年度: 13,260千円 (直接経費: 10,200千円、間接経費: 3,060千円); 2008年度: 15,470千円 (直接経費: 11,900千円、間接経費: 3,570千円); 2007年度: 19,890千円 (直接経費: 15,300千円、間接経費: 4,590千円); 2006年度: 40,950千円 (直接経費: 31,500千円、間接経費: 9,450千円)
• キーワード: ゲノム / 発現制御 / 肝臓 / 栄養 / 生活習慣病 / 糖尿病

研究概要

肝臓は、糖・タンパク・脂質の代謝や薬物および異物の解毒を専門とする巨大な臓器である。大量の物質を血液から取り込んで代謝し、全身の臓器に代謝物を供給する。21世紀の最大の課題である動脈硬化、糖尿病、癌、炎症といった栄養状態が関与する症候群に、肝臓の機能破綻が大きく関与している可能性を示した。本研究は、過栄養状態における肝臓の変化を明らかにすることによって新たな肝臓病の疾病概念を確立するとともに、肝臓機能の破綻によって生じる肝代謝異常の診断および治療法開発の基盤となるべき研究を行った。

研究成果

• [雑誌論文] Identification of a secretory protein cl9orfl0 activated in hepatocellular carcinoma. (2011)
  • 著者名/発表者名: H Sunagozaka
  • 雑誌名: Int J Cancer 巻: (in press)
  • 査読あり
• [雑誌論文] A liver-derived secretory protein, selenoprotein P, causes insulin resistance. (2010)
  • 著者名/発表者名: H Misu, T Takamura, H Takayama, H Hayashi, N Matsuzawa-Nagata, S Kurita, K Ishikura, H Ando, Y Takeshita, T Ota, M Sakurai, T Yamashita, E Mizukoshi, T Yamashita, M Honda, K Miyamoto, T Kubota, N Kubota, T Kadowaki, HJ Kim, IK Lee, Y Minokoshi, Y Saito, K Takahashi, Y Yamada, N Takakura, S Kaneko.
  • 雑誌名: Cell Metab 12(5) ページ: 483-495
  • NAID: 120002661942
  • 査読あり
• [雑誌論文] Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis (2010)
  • 著者名/発表者名: M Honda, M Nakamura, M Tateno, A Sakai, T Shimakami, T Shirasaki, T Yamashita, K Arai, T Yamashita, Y Sakai, S Kaneko.
  • 雑誌名: C.J Hepatol 53(5) ページ: 817-826
  • 査読あり
• [雑誌論文] Hokuriku Liver Study Group. Differential gene expression profiling in blood from patients with digestive system cancers. (2010)
  • 著者名/発表者名: M Honda, Y Sakai, T Yamashita, T Yamashita, A Sakai, E Mizukoshi, Y Nakamoto, I Tatsumi, Y Miyazaki, H Tanno, S Kaneko
  • 雑誌名: Biochem Biophys Res Commun 400(1) ページ: 7-15
  • 査読あり
• [雑誌論文] Hepatocellular Carcinoma : Signal Intensity at Gadoxetic Acid-enhanced MR Imaging-Correlation with Molecular Transporters and Histopathologic Features. (2010)
  • 著者名/発表者名: A Kitao, Y Zen, O Matsui, T Gabata, S Kobayashi, W Koda, K Kozaka, N Yoneda, T Yamashita, S Kaneko, Y Nakanuma.
  • 雑誌名: Radiology 256(3) ページ: 817-826
  • 査読あり
• [雑誌論文] Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α. (2010)
  • 著者名/発表者名: S Kaneko
  • 雑誌名: Cancer Res 70(16) ページ: 6556-6565
  • 査読あり
• [雑誌論文] Hokuriku Liver Study Group. Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C. (2010)
  • 著者名/発表者名: M Honda, A Sakai, T Yamashita, Y Nakamoto, E Mizukoshi, Y Sakai, T Yamashita, M Nakamura, T Shirasaki, K Horimoto, Y Tanaka, K Tokunaga, M Mizokami, S Kaneko
  • 雑誌名: Gastroenterology 139(2) ページ: 499-509
  • 査読あり
• [雑誌論文] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. (2010)
  • 著者名/発表者名: T Yamashita, M Honda, K Nio, Y Nakamoto, T Yamashita, H Takamura, T Tani, Y Zen, S Kaneko.
  • 雑誌名: Cancer Res 70(11) ページ: 4687-4697
  • NAID: 120002220837
  • 査読あり
• [雑誌論文] Enhancement of tumor-specific T cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma. (2010)
  • 著者名/発表者名: S Kaneko
  • 雑誌名: Int J Cancer 126(9) ページ: 2164-2174
  • 査読あり
• [雑誌論文] Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma. (2010)
  • 著者名/発表者名: Y Hodo, SI Hashimoto, M Honda, T Yamashita, Y Suzuki, S Sugano, S Kaneko, K Matsushima.
  • 雑誌名: Genomics 95(4) ページ: 217-223
  • NAID: 120002086414
  • 査読あり
• [雑誌論文] CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes. (2010)
  • 著者名/発表者名: T Komura, Y Sakai, M Honda, T Takamura, K Matsushima, S Kaneko.
  • 雑誌名: Diabetes 59(3) ページ: 634-643
  • NAID: 120002104558
  • 査読あり
• [雑誌論文] Altered hepatic gene expression profiles associated with myocardial ischemia. (2010)
  • 著者名/発表者名: H Ootsuji, M Honda, S Kaneko, S Usui, M Okajima, H Okada, Y Sakai, T Takamura, K Horimoto, M Takamura.
  • 雑誌名: Circ Cardiovasc Genet 3(1) ページ: 68-77
  • 査読あり
• [雑誌論文] The histological course of nonalcoholic fatty liver disease in Japanese patients : Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. (2010)
  • 著者名/発表者名: E Hamaguchi, T Takamura, M Sakurai, E Mizukoshi, Y Zen, Y Takeshita, S Kurita, K Arai, T Yamashita, M Sasaki, Y Nakanuma, S Kaneko.
  • 雑誌名: Diabetes Care 33(2) ページ: 284-286
  • NAID: 120001938902
  • 査読あり
• [雑誌論文] Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice. (2010)
  • 著者名/発表者名: K Kakinoki
  • 雑誌名: J Gene Med 巻: 12 ページ: 1002-1013
  • 査読あり
• [雑誌論文] A liver-derived secretory protein, selenoprotein P, causes insulin resistance. (2010)
  • 著者名/発表者名: H Misu
  • 雑誌名: Cell Metab 巻: 12 ページ: 483-495
  • 査読あり
• [雑誌論文] Efficacy and safety of double filtration plasmapheresis in combination with interferon therapy for chronic hepatitis C. (2010)
  • 著者名/発表者名: S Kaneko
  • 雑誌名: Hepatol Res 巻: 40 ページ: 1072-1081
  • 査読あり
• [雑誌論文] Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization. (2010)
  • 著者名/発表者名: H Nuriya
  • 雑誌名: J Clin Microbiol 巻: 48 ページ: 3843-3851
  • 査読あり
• [雑誌論文] Differential interferon signaling in liver lobule and portal area cells under treatment foi chronic hepatitis C. (2010)
  • 著者名/発表者名: M Honda
  • 雑誌名: J Hepatol 巻: 53 ページ: 317-826
  • 査読あり
• [雑誌論文] Differential gene expression profiling in blood from patients with digestive system cancers. (2010)
  • 著者名/発表者名: M Honda
  • 雑誌名: Biochem Biophys Res Commun 巻: 400 ページ: 7-15
  • 査読あり
• [雑誌論文] Hepatocellular Carcinoma : Signal Intensity at Gadoxetic Acid-enhanced MR Imaging--Correlation with Molecular Transporters and Histopathologic Features. (2010)
  • 著者名/発表者名: A Kitao
  • 雑誌名: Radiology 巻: 256 ページ: 817-826
  • 査読あり
• [雑誌論文] Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α. (2010)
  • 著者名/発表者名: N Iida
  • 雑誌名: Cancer Res 巻: 70 ページ: 6556-6565
  • 査読あり
• [雑誌論文] Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C. (2010)
  • 著者名/発表者名: M Honda
  • 雑誌名: Gastroenterology 巻: 139 ページ: 1499-509
  • 査読あり
• [雑誌論文] La Protein Required for Internal Ribosome Entry Site-Directed Translation Is a Potential Therapeutic Target for Hepatitis C V rus Replication. (2010)
  • 著者名/発表者名: T Shirasaki
  • 雑誌名: J Infect Dis 巻: 202 ページ: 75-85
  • 査読あり
• [雑誌論文] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing henatocvtic differentiation. (2010)
  • 著者名/発表者名: T Yamashita
  • 雑誌名: I Cancer Res ページ: 4687-4697
  • 査読あり
• [雑誌論文] Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTNI. (2010)
  • 著者名/発表者名: Y Kato
  • 雑誌名: Pharm Res 巻: 27 ページ: 832-840
• [雑誌論文] Enhancement of tumor-specific T cell responses by transcatheter arterial embolization wit dendritic cell infusion for hepatocellular carcinoma. (2010)
  • 著者名/発表者名: E Mizukoshi
  • 雑誌名: Int J Cancer 巻: 126 ページ: 2164-2174
  • 査読あり
• [雑誌論文] Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver. (2010)
  • 著者名/発表者名: Y Wu
  • 雑誌名: Oncogene 巻: 29 ページ: 2228-2237
  • 査読あり
• [雑誌論文] Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma. (2010)
  • 著者名/発表者名: Y Hodo
  • 雑誌名: Genomics 巻: 95 ページ: 217-223
  • 査読あり
• [雑誌論文] Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver (2010)
  • 著者名/発表者名: Y Wu
  • 雑誌名: Oncogene (in press)
  • 査読あり
• [雑誌論文] Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma (2010)
  • 著者名/発表者名: Y Hodo
  • 雑誌名: Genomics (in press)
  • 査読あり
• [雑誌論文] dUTP pyrophosphatase expression correlates with a poor prognosis in he patocellular carcinoma (2010)
  • 著者名/発表者名: H Takatori
  • 雑誌名: Liver Int (in press)
  • 査読あり
• [雑誌論文] A randomized trial of 24 versus 48 weeks of peginterferon α-2a in patients infected with chronic hepatitis C virus genotype 2 or low viral load genotype 1 : a multicenter national study in Japan (2010)
  • 著者名/発表者名: Y Iwasaki
  • 雑誌名: Hepatol Int (in press)
  • 査読あり
• [雑誌論文] Enhancement of tumor-specific T cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma (2010)
  • 著者名/発表者名: E Mizukoshi
  • 雑誌名: Int J Cancer 126 ページ: 2164-74
  • 査読あり
• [雑誌論文] CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes (2010)
  • 著者名/発表者名: T Komura
  • 雑誌名: Diabetes 59 ページ: 634-43
  • 査読あり
• [雑誌論文] The histological course of nonalcoholic fatty liver disease in Japanese patients : Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis (2010)
  • 著者名/発表者名: E Hamaguchi
  • 雑誌名: Diabetes Care 33 ページ: 284-286
  • 査読あり
• [雑誌論文] J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes : an 8-year follow-up of relatively lean Japanese individuals. (2009)
  • 著者名/発表者名: M Sakurai, K Miura, T Takamura, M Ishizaki, Y Morikawa, K Nakamura, K Yoshita, T Kido, Y Naruse, S Kaneko, H Nakagawa.
  • 雑誌名: Diabet Med 26(8) ページ: 753-759
  • NAID: 120001507851
  • 査読あり
• [雑誌論文] Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria. (2009)
  • 著者名/発表者名: S Nakamura, T Takamura, N Matsuzawa-Nagata, H Takayama, H Misu, H Noda, S Nabemoto, S Kurita, T Ota, H Ando, K Miyamoto, S Kaneko.
  • 雑誌名: J Biol Chem 284(22) ページ: 14809-14818
  • NAID: 120002829203
  • 査読あり
• [雑誌論文] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. (2009)
  • 著者名/発表者名: H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, S Nakamura, M Kumazaki, S Kurita, H Misu, N Togawa, T Fukushima, A Fujimura, S Kaneko.
  • 雑誌名: Biochem Biophys Res Commun 380(3) ページ: 684-688
  • NAID: 120001170074
  • 査読あり
• [雑誌論文] Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities. (2009)
  • 著者名/発表者名: M Sakurai, T Takamura, K Miura, S Kaneko, H Nakagawa.
  • 雑誌名: Metabolism 58(4) ページ: 456-459
  • NAID: 120001249808
  • 査読あり
• [雑誌論文] Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. (2009)
  • 著者名/発表者名: S Ura, M Honda, T Yamashita, T Ueda, H Takatori, R Nishino, H Sunakozaka, Y Sakai, K Horimoto, S Kaneko.
  • 雑誌名: Hepatology 49(4) ページ: 1098-1112
  • 査読あり
• [雑誌論文] EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features. (2009)
  • 著者名/発表者名: T Yamashita, J Ji, A Budhu, M Forgues, W Yang, HY Wang, H Jia, Q Ye, LX Qin, E Wauthier, LM Reid, H Minato, M Honda, S Kaneko, ZY Tang, XW Wang.
  • 雑誌名: Gastroenterology 136(3) ページ: 1012-1024
  • 査読あり
• [雑誌論文] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. (2009)
  • 著者名/発表者名: H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, T Eto, H Misu, M Shiramoto, T Tsuru, S Irie, A Fujimura, S Kaneko.
  • 雑誌名: Diabetologia 52(2) ページ: 329-335
  • 査読あり
• [雑誌論文] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. (2009)
  • 著者名/発表者名: T Yamashita, M Honda, H Takatori, R Nishino, H Minato, H Takamura, T Ohta, S Kaneko.
  • 雑誌名: J Hepatology 50(1) ページ: 100-110
  • 査読あり
• [雑誌論文] Altered hepatic gene expression profiles associated with myocardial is chemia (2009)
  • 著者名/発表者名: H Ootsuji
  • 雑誌名: Circ Cardiovasc Genet 3 ページ: 68-77
  • 査読あり
• [雑誌論文] J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes : an 8-year follow-up of relatively lean Japanese individuals (2009)
  • 著者名/発表者名: M Sakurai
  • 雑誌名: Diabet Med 26 ページ: 753-759
  • 査読あり
• [雑誌論文] Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria (2009)
  • 著者名/発表者名: S Nakamura
  • 雑誌名: J Biol Chem 284 ページ: 14809-14818
  • 査読あり
• [雑誌論文] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis (2009)
  • 著者名/発表者名: H Ando
  • 雑誌名: Biochem Biophys Res Commun 380 ページ: 684-688
  • 査読あり
• [雑誌論文] Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities (2009)
  • 著者名/発表者名: M Sakurai
  • 雑誌名: Metabolism 58 ページ: 456-459
  • 査読あり
• [雑誌論文] Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma (2009)
  • 著者名/発表者名: S Ura
  • 雑誌名: Hepatology 49 ページ: 1098-1112
  • 査読あり
• [雑誌論文] EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features (2009)
  • 著者名/発表者名: T Yamashita
  • 雑誌名: Gastroenterology 136 ページ: 1012-1024
  • 査読あり
• [雑誌論文] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes (2009)
  • 著者名/発表者名: H Ando
  • 雑誌名: Diabetologia 52 ページ: 329-335
  • 査読あり
• [雑誌論文] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma (2009)
  • 著者名/発表者名: T Yamashita
  • 雑誌名: J Hepatology 50 ページ: 100-110
  • 査読あり
• [雑誌論文] Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. (2009)
  • 著者名/発表者名: S Ura
  • 雑誌名: Hepatology (in press)
  • 査読あり
• [雑誌論文] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. (2009)
  • 著者名/発表者名: H Ando
  • 雑誌名: Diabetologia 52 ページ: 329-335
  • 査読あり
• [雑誌論文] Middle-aged Japanese women are resistant to obesity-related me tabolic abnormalities. (2009)
  • 著者名/発表者名: M Sakurai
  • 雑誌名: Metabolism 58 ページ: 456-459
  • 査読あり
• [雑誌論文] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. (2009)
  • 著者名/発表者名: T Yamashita
  • 雑誌名: J Hepatology 50 ページ: 100-110
  • 査読あり
• [雑誌論文] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. (2009)
  • 著者名/発表者名: H Ando
  • 雑誌名: Biochem Biophys Res Commun 380 ページ: 684-688
  • 査読あり
• [雑誌論文] Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients. (2008)
  • 著者名/発表者名: Y Sakai, M Honda, H Fujinaga, I Tatsumi, E Mizukoshi, Y Nakamoto, S Kaneko.
  • 雑誌名: Cancer Res 68(24) ページ: 10267-10279
  • 査読あり
• [雑誌論文] Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. (2008)
  • 著者名/発表者名: T Takamura, H Misu, N Matsuzawa-Nagata, M Sakurai, T Ota, A Shimizu, S Kurita, Y Takeshita, H Ando, M Honda, S Kaneko.
  • 雑誌名: Obesity (Silver Spring) 16(12) ページ: 2601-2609
  • 査読あり
• [雑誌論文] Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE. (2008)
  • 著者名/発表者名: H Minagawa, T Yamashita, M Honda, Y Tabuse, K Kamijo, A Tsugita, S Kaneko.
  • 雑誌名: Protein J 27(7-8) ページ: 409-419
  • 査読あり
• [雑誌論文] SAGE application in the study of diabetes. (2008)
  • 著者名/発表者名: T Takamura, H Misu, T Yamashita, S Kaneko.
  • 雑誌名: Curr Pharm Biotechnol 9(5) ページ: 392-399
  • 査読あり
• [雑誌論文] Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suiside gene therapy against hepatocelluar carcinoma by M1 macrophage activation. (2008)
  • 著者名/発表者名: T Tsuchiyama, Y Nakamoto, Y Sakai, N Mukaida, S Kaneko.
  • 雑誌名: Cancer Sci 99(10) ページ: 2075-2082
  • 査読あり
• [雑誌論文] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. (2008)
  • 著者名/発表者名: N Matsuzawa-Nagata, T Takamura, H Ando, S Nakamura, S Kurita, H Misu, T Ota, M Yokoyama, M Honda, K Miyamoto, S Kaneko.
  • 雑誌名: Metabolism 57(8) ページ: 1071-1077
  • NAID: 120001130340
  • 査読あり
• [雑誌論文] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. (2008)
  • 著者名/発表者名: M Uno, S Kurita, H Misu, H Ando, T Ota, N Matsuzawa-Nagata, Y Kita, S Nabemoto, H Akahori, Y Zen, Y Nakanuma, S Kaneko, T Takamura.
  • 雑誌名: Hepatology 48(1) ページ: 109-118
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• [雑誌論文] Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis. (2006)
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  • 著者名/発表者名: T Shimakami
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• [雑誌論文] Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer. (2006)
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  • 雑誌名: Cancer Gene Ther 13・4 ページ: 357-366
• [雑誌論文] Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes. (2006)
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• [雑誌論文] Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. (2006)
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• [備考] ホームページ等
  • URL: http://m-kanazawa.jp/
• [備考]
  • URL: http://m-kanazawa.jp/
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  • URL: http://m-kanazawa.jp/
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  • URL: http://www.m-kanazawa.jp
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• [産業財産権] 脂肪組織由来間質細胞群を含む肝炎治療剤 (2010)
  • 発明者名: 東元真実、金子周一、酒井佳夫
  • 権利者名: 金沢大学
  • 産業財産権番号: 2010-203796
  • 出願年月日: 2010-09-11
• [産業財産権] 脂肪組織由来間質細胞群を含む肝炎治療剤 (2010)
  • 発明者名: 東元真実, 金子周一, 酒井佳夫
  • 権利者名: 金沢大学
  • 産業財産権番号: 2010-203796
  • 出願年月日: 2010-09-11
• [産業財産権] 腎症の進行度の判定方法並びに線維化抑制剤 (2010)
  • 発明者名: 坂井宣彦, 金子周一, 和田隆志
  • 権利者名: 金沢大学
  • 産業財産権番号: 2010-281080
  • 出願年月日: 2010-12-16
• [産業財産権] 遺伝子発現プロファイルによる消化器癌、胃癌、大腸癌及び膵臓癌の検出 (2009)
  • 発明者名: 金子周一、本多政夫、酒井佳夫、山下太郎
  • 権利者名: 金沢大学
  • 産業財産権番号: 2009-193702
  • 出願年月日: 2009-08-24
• [産業財産権] 遺伝子発現プロファイルによる消火器癌, 胃癌, 大腸癌及び膵臓癌の検出 (2009)
  • 発明者名: 金子周一, 本多政夫, 酒井佳夫
  • 権利者名: 国立大学法人 金沢大学
  • 産業財産権番号: 2009-193702
  • 出願年月日: 2009-08-24
• [産業財産権] 生理的状態分析方法、生理的状態分析システム、及びコンピュータシステムに生理的状態を分析するための処理を実行させるコンピュータープログラム (2008)
  • 発明者名: 松原謙一、下田正文、的場亮、谷野元彦、中村誠二、岡山利次、田村卓郎、金子周一、篁俊成、河合昴三
  • 権利者名: (株) DNAチップ研究所、ビッツ(株)
  • 産業財産権番号: 2008-311346
  • 出願年月日: 2008-12-05
• [産業財産権] 生理的状態分析方法、生理的状態分析システム、及びコンピュータシステムに生理的状態を分析するための処理を実行させるコンピュータープログラム (2008)
  • 発明者名: 松原謙一, 下田正文, 的場亮, 谷野元彦, 中村誠二, 岡山利次, 田村卓郎, 金子周一, 篁俊成, 河合昴三
  • 権利者名: (株)DNAチップ研究所, ビッツ(株)
  • 出願年月日: 2008-12-05