DNAポリメラーゼイオタ欠損マウスの作製とその肺発がん感受性の解析

• 研究課題/領域番号: 18590384
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 実験病理学
• 研究機関: 高知大学
• 研究代表者: 李 康弘 高知大学, 教育研究部医療学系, 教授 (10261405)
• 研究期間 (年度): 2006 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 3,970千円 (直接経費: 3,400千円、間接経費: 570千円); 2008年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円); 2007年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2006年度: 1,500千円 (直接経費: 1,500千円)
• キーワード: 腫瘍 / 発がん感受性 / 量的形質 / 連鎖解析 / 肺発がん / 抵抗性遺伝子 / Polτ / ノックアウトマウス / Poli / Polt

研究概要

DNA ポリメラーゼイオタは、我々が発見した肺発がん抵抗性遺伝子座の有力な候補遺伝子である。この遺伝子の欠損が肺発がんに及ぼす影響を直接的に調べるため、DNAポリメラーゼイオタ欠損マウスの樹立を遺伝子工学技術によって試み、成功した。しかし、樹立の過程は様々な要因により当初計画よりも遅れを生じたため、3 年間の研究期間で肺発がん感受性実験の終了にまで至ることができなかった。2009 年度以降も外部資金獲得に努め、研究を継続する。

研究成果

• [雑誌論文] Ureteral small cell carcinoma (2009)
  • 著者名/発表者名: Kuroda N, Katto K, TamuraM, Shiotsu T, Inoue K, Ohara M, Mizuno K, Lee G-H.
  • 雑誌名: Med Mol Morphol 42 ページ: 55-57
  • 査読あり
• [雑誌論文] Ureteral small cell carcinoma. (2009)
  • 著者名/発表者名: Kuroda N, Katto K, Tamura M, Shiotsu T, Inoue K, Ohara M, Mizuno K, Lee GH
  • 雑誌名: Med Mol Morphol 42 ページ: 55-57
  • 査読あり
• [雑誌論文] Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway (2008)
  • 著者名/発表者名: Radhakrishnan G, Suzuki R, Maeda H, Yamamoto M, Hirose N, Gopalrao RK, Lee G-H, Hayashi Y, Rao P, Sasaguri S.
  • 雑誌名: Circ J. 72 ページ: 800-806
  • 査読あり
• [雑誌論文] Carcinoid tumor of the renal pelvis : consideration on the histogenesis (2008)
  • 著者名/発表者名: Kuroda N, Katto K, TamuraM, Shiotsu T, Hes O, Michal M, Nagashima Y, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
  • 雑誌名: Pathol Int. 58 ページ: 51-54
  • 査読あり
• [雑誌論文] Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification (2008)
  • 著者名/発表者名: Ohtsuki Y, Yamanaka A, Ohyama H, Yamada E, Terada N, Fujita J, Lee G-H, Furihata M.
  • 雑誌名: Histol Histopathol 23 ページ: 137-141
  • 査読あり
• [雑誌論文] Radhakrishnan G, Rao P, Sasaguri S. The local injection of peritoneal macrophages induces neovascularization in rat ischemic hind limb muscles (2008)
  • 著者名/発表者名: Hirose N, Maeda H, Yamamoto M, Hayashi Y, Lee G-H, Chen L.
  • 雑誌名: Cell Transplant 17 ページ: 211-222
  • 査読あり
• [雑誌論文] Possible identification of third stromal component in extraadrenal paraganglioma : myofibroblast in fibrous band and capsule (2008)
  • 著者名/発表者名: Kuroda N, Tamura M, Ohara M, Hirouchi T, Mizuno K, Miyazaki E, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 59-61
  • 査読あり
• [雑誌論文] Furihata M. Multiple minute nests of incidentally detected paraganglionic cells associated with urothelial carcinoma of the urinary bladder in a 73 year-old woman (2008)
  • 著者名/発表者名: Ohtsuki Y, Ochi K, Okada Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 62-65
  • 査読あり
• [雑誌論文] Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor (2008)
  • 著者名/発表者名: Kuroda N, Tanida N, Oonishi K, Inoue K, Ohara M, Mizuno K, Taguchi T, Hayashi Y, Hanazaki K, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 109-112
  • 査読あり
• [雑誌論文] Basal-like carcinoma of the breast : further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas (2008)
  • 著者名/発表者名: Kuroda N, Fujishima N, Inoue K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 117-120
  • 査読あり
• [雑誌論文] Furihata M. Micropapillary component of urothelial carcinoma detected in transurethral resection of bladder tumor (TUR-BT) tissues : a case report (2008)
  • 著者名/発表者名: Ohtsuki Y, Ochi K, Okada Y, Kato M, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 113-116
  • 査読あり
• [雑誌論文] Furihata M. Immunohistochemical localisation of surfactant proteins A and D, and KL-6 in pulmonary alveolar proteinosis (2008)
  • 著者名/発表者名: Ohtsuki Y, Kobayashi M, Yoshida S, Kishimoto N, Kubo K, Yokoyama A, Lee G-H.
  • 雑誌名: Pathology 40 ページ: 536-539
  • 査読あり
• [雑誌論文] Sarcomatoid acquired cystic disease-associated renal cell carcinoma (2008)
  • 著者名/発表者名: Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee G-H.
  • 雑誌名: Histol Histopathol 23 ページ: 1327-1331
  • 査読あり
• [雑誌論文] A rare case of coexistence of pulmonary adenocarcinoma with Langerhans' cell histiocytosis (2008)
  • 著者名/発表者名: Ohtsuki Y, Uomoto M, Hachisuka Y, Kato M, Iguchi M, Lee G-H, Furihata M.
  • 雑誌名: Med Mol Morphol 41 ページ: 175-178
  • 査読あり
• [雑誌論文] Elastofibroma : a histochemical, immunohistochemical, and ultrastructural study of two patients (2008)
  • 著者名/発表者名: Kuroda N, Hamaguchi N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 179-182
  • 査読あり
• [雑誌論文] Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3 : a histological, immunohistochemical, ultrastructural and FISH study (2008)
  • 著者名/発表者名: Kuroda N, Hes O, Michal M, Nemcova J, Gal V, Yamaguchi T, Kawada T, Imamura Y, Hayashi Y, Lee G-H.
  • 雑誌名: Histol Histopathol 23 ページ: 1517-1523
  • 査読あり
• [雑誌論文] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development (2008)
  • 著者名/発表者名: Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee G-H.
  • 雑誌名: Cell Tissue Res. 334 ページ: 219-226
  • 査読あり
• [雑誌論文] Ultrastructural study of the morphogenesis of human herpesvirus 6 type B in human T-lymphotropic virus type I-producing lymphoid cells (2008)
  • 著者名/発表者名: Ohtsuki Y, Daibata M, Bandobashi K, Lee G-H, Furihata M, Yokoyama A, Miyoshi I.
  • 雑誌名: Med Mol Morphol 41 ページ: 204-210
  • 査読あり
• [雑誌論文] Chromophobe renal cell carcinoma : useful diagnostic application of imprint cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants (2008)
  • 著者名/発表者名: Kuroda N, Katto K, Yamaguchi T, Kawada T, Imamura Y, Hes O, Michal M, Shuin T, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 227-232
  • 査読あり
• [雑誌論文] Coexistent adenomyoepithelioma and invasive ductal carcinoma of the breast : presentation as separate tumors (2008)
  • 著者名/発表者名: Kuroda N, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 238-242
  • 査読あり
• [雑誌論文] The Kras2 oncogene and mouse lung carcinogenesis (2008)
  • 著者名/発表者名: Lee G-H.
  • 雑誌名: Med Mol Morphol 41 ページ: 199-203
  • 査読あり
• [雑誌論文] The Kras2 oncogene and mouse lung carcinogenesis. (2008)
  • 著者名/発表者名: Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 199-203
  • 査読あり
• [雑誌論文] Coexistent adenomyoepithelioma and invasive ductal carcinoma of the breast : presentation as separate tumors. (2008)
  • 著者名/発表者名: Kuroda N, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 238-242
  • 査読あり
• [雑誌論文] Chromophobe renal cell carcinoma : useful diagnostic application of imprint cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants. (2008)
  • 著者名/発表者名: Kuroda N, Katto K, Yamaguchi T, Kawada T, Imamura Y, Hes O, Michal M, Shuin T, Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 227-232
  • 査読あり
• [雑誌論文] Ultrastructural study of the morphogenesis of human herpesvirus 6 type B in human T-lymphotropic virus type I-producing lymphoid cells. (2008)
  • 著者名/発表者名: Ohtsuki Y, Daibata M, Bandobashi K, Lee GH, Furihata M, Yokoyama A, Miyoshi I
  • 雑誌名: Med Mol Morphol 41 ページ: 204-210
  • 査読あり
• [雑誌論文] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development. (2008)
  • 著者名/発表者名: Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH
  • 雑誌名: Cell Tissue Res 334 ページ: 219-226
  • 査読あり
• [雑誌論文] Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3 : a histological, immunohistochemical, ultrastructural and FISH study. (2008)
  • 著者名/発表者名: Kuroda N, Hes O, Michal M, Nemcova J, Gal V, Yamaguchi T, Kawada T, Imamura Y, Hayashi Y, Lee GH
  • 雑誌名: Histol Histopathol 23 ページ: 1517-1523
  • 査読あり
• [雑誌論文] Elastofibroma : a histochemical, immunohistochemical, and ultrastructural study of two patients. (2008)
  • 著者名/発表者名: Kuroda N, Hamaguchi N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 179-182
  • 査読あり
• [雑誌論文] A rare case of coexistence of pulmonary adenocarcinoma with Langerhans' cell histiocytosis. (2008)
  • 著者名/発表者名: Ohtsuki Y, Uomoto M, Hachisuka Y, Kato M, Iguchi M, Lee GH, Furihata M
  • 雑誌名: Med Mol Morphol 41 ページ: 175-178
  • 査読あり
• [雑誌論文] Sarcomatoid acquired cystic disease-associated renal cell carcinoma. (2008)
  • 著者名/発表者名: Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee GH
  • 雑誌名: Histol Histopathol 23 ページ: 1327-1331
  • 査読あり
• [雑誌論文] Immunohistochemical localisation of surfactant proteins A and D, and KL-6 in pulmonary alveolar proteinosis. (2008)
  • 著者名/発表者名: Ohtsuki Y, Kobayashi M, Yoshida S, Kishimoto N, Kubo K, Yokoyama A, Lee GH, Furihata M
  • 雑誌名: Pathology 40 ページ: 536-539
  • 査読あり
• [雑誌論文] Micropapillary component of urothelial carcinoma detected in transurethral resection of bladder tumor (TUR-BT) tissues : a case report. (2008)
  • 著者名/発表者名: Ohtsuki Y, Ochi K, Okada Y, Kato M, Lee GH, Furihata M
  • 雑誌名: Med Mol Morphol 41 ページ: 113-116
  • 査読あり
• [雑誌論文] Basal-like carcinoma of the breast : further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas. (2008)
  • 著者名/発表者名: Kuroda N, Fujishima N, Inoue K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 117-120
  • 査読あり
• [雑誌論文] Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor. (2008)
  • 著者名/発表者名: Kuroda N, Tanida N, Oonishi K, Inoue K, Ohara M, Mizuno K, Taguchi T, Hayashi Y, Hanazaki K, Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 109-112
  • 査読あり
• [雑誌論文] Multiple minute nests of incidentally detected paraganglionic cells associated with urothelial carcinoma of the urinary bladder in a 73 year-old woman. (2008)
  • 著者名/発表者名: Ohtsuki Y, Ochi K, Okada Y, Lee GH, Furihata M
  • 雑誌名: Med Mol Morphol 41 ページ: 62-65
  • 査読あり
• [雑誌論文] Possible identification of third stromal component in extraadrenal paraganglioma : myofibroblast in fibrous band and capsule. (2008)
  • 著者名/発表者名: Kuroda N, Tamura M, Ohara M, Hirouchi T, Mizuno K, Miyazaki E, Hayashi Y, Lee GH
  • 雑誌名: Med Mol Morphol 41 ページ: 59-61
  • 査読あり
• [雑誌論文] The local injection of peritoneal macrophages induces neovascularization in rat ischemic hind limb muscles. (2008)
  • 著者名/発表者名: Hirose N, Maeda H, Yamamoto M, Hayashi Y, Lee GH, Chen L, Radhakrishnan G, Rao P, Sasaguri S
  • 雑誌名: Cell Transplant 17 ページ: 211-222
  • 査読あり
• [雑誌論文] Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification. (2008)
  • 著者名/発表者名: Ohtsuki Y, Yamanaka A, Ohyama H, Yamada E, Terada N, Fujita J, Lee GH, Furihata M
  • 雑誌名: Histol Histopathol 23 ページ: 137-141
  • 査読あり
• [雑誌論文] Carcinoid tumor of the renal pelvis : consideration on the histogenesis. (2008)
  • 著者名/発表者名: Kuroda N, Katto K, Tamura M, Shiotsu T, Hes O, Michal M, Nagashima Y, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH
  • 雑誌名: Pathol Int 58 ページ: 51-54
  • 査読あり
• [雑誌論文] Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway. (2008)
  • 著者名/発表者名: Radhakrishnan G, Suzuki R, Maeda H, Yamamoto M, Hirose N, Gopalrao RK, Lee GH, Hayashi Y, Rao P, Sasaguri S
  • 雑誌名: Circ J 72 ページ: 800-806
  • 査読あり
• [雑誌論文] Carcinoid tumor of the renal pelvis:Consideration on the histogenesis (2008)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Pathol Int 58 ページ: 51-54
  • 査読あり
• [雑誌論文] Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification (2008)
  • 著者名/発表者名: Ohtsuki Y, et. al.
  • 雑誌名: Histol Histopathol 23 ページ: 137-141
  • 査読あり
• [雑誌論文] Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome (2007)
  • 著者名/発表者名: Kuroda N, Amano S, Shiotsu T, Tamura M, Hes O, Michal M, Lee G-H.
  • 雑誌名: APMIS 115 ページ: 1292-1295
  • 査読あり
• [雑誌論文] H. An Asian variant of intravascular lymphoma : unique clinical and pathological manifestation in the gallbladder (2007)
  • 著者名/発表者名: Kuroda N, Mizobuchi M, Shimamura Y, Taniguchi Y, Daibata M, Miyoshi I, Ichimura T, Beppu H, Ohara M, Hirouchi T, Mizuno K, Lee G-H.
  • 雑誌名: APMIS 115 ページ: 371-375
  • 査読あり
• [雑誌論文] Renal leiomyoma : an immunohistochemical, ultrastructural and comparative genomic hybridization study (2007)
  • 著者名/発表者名: Kuroda N, Inoue Y, Taguchi T, Tominaga A, Hes O, Michal M, Hayashi Y, Hiroi M, Shuin T, Lee G-H.
  • 雑誌名: Histol Histopathol 22 ページ: 883-888
  • 査読あり
• [雑誌論文] Invasive ductal carcinoma of the breast with signet-ring cell and mucinous carcinoma components : diagnostic utility of immunocytochemistry of signet-ring cells in aspiration cytology materials (2007)
  • 著者名/発表者名: Kuroda N, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Lee G-H.
  • 雑誌名: Diagn Cytopathol 35 ページ: 171-173
  • 査読あり
• [雑誌論文] Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection (2007)
  • 著者名/発表者名: Yamamoto M, Maeda H, Hirose N, Radhakrishnan G, Katare RG, Hayashi Y, Rao P, Lee G-H, Yamaguchi T, Sasaguri S.
  • 雑誌名: Am J Transplant 7 ページ: 1897-1906
  • 査読あり
• [雑誌論文] Invasive micropapillary carcinoma of the colon : an immunohistochemical study (2007)
  • 著者名/発表者名: Kuroda N, Oonishi K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 40 ページ: 226-230
  • 査読あり
• [雑誌論文] Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures (2007)
  • 著者名/発表者名: Kuroda N, Iwamura S, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 40 ページ: 168-171
  • 査読あり
• [雑誌論文] Large cell neuroendocrine carcinoma of the lung with calcification and expression of osteopontin (2007)
  • 著者名/発表者名: Kuroda N, Hamaguchi N, Ohara M, Hirouchi T, Mizuno K, Lee G-H.
  • 雑誌名: Med Mol Morphol 40 ページ: 218-220
  • 査読あり
• [雑誌論文] Immunohistochemical and electron microscopic studies of Langerhans cells in a case of multiple eccrine spiradenomas (2007)
  • 著者名/発表者名: Ohtsuki Y, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 221-225
  • 査読あり
• [雑誌論文] Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia (2007)
  • 著者名/発表者名: Ohtsuki Y, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 198-202
  • 査読あり
• [雑誌論文] Diagnostic pitfall of D2-40 in adenomatosid tumour (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Histopathology 51 ページ: 719-721
  • 査読あり
• [雑誌論文] Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 168-171
  • 査読あり
• [雑誌論文] Immunohistochemical distribution of SP-D, compared with that of SP-A and KL-6, in interstitial pneumonias (2007)
  • 著者名/発表者名: Ohtsuki Y, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 163-167
  • 査読あり
• [雑誌論文] Prostatic adenocarcinoma with Paneth cell-like change (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: APMIS 115 ページ: 857-858
  • 査読あり
• [雑誌論文] Renal leiomyoma:an immunohistochemical, ultrastructural and comparative genomic hybridization study (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Histol Histopathol 22 ページ: 883-888
  • 査読あり
• [雑誌論文] Invasive ductal carcinoma of the breast with signet-ring cell and mucinous carcinoma components:diagnostic utility of immunocytochemistry of signet-ring cells in aspiration cytology materials (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Diagn Cytopathol 35 ページ: 171-173
  • 査読あり
• [雑誌論文] Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 50-53
  • 査読あり
• [雑誌論文] Hyaline globule-like structures in undifferentiated sarcoma cells of malignant mullerian mixed tumor of the fallopian tube (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 46-49
  • 査読あり
• [雑誌論文] Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: APMIS 115 ページ: 1292-1295
  • 査読あり
• [雑誌論文] Invasive micropapillary carcinoma of the colon:an immunohistochemical study (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 226-230
  • 査読あり
• [雑誌論文] Large cell neuroendocrine carcinoma of the lung with calcification and expression of osteopontin (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: Med Mol Morphol 40 ページ: 218-220
  • 査読あり
• [雑誌論文] An Asian variant of intravascular lymphoma:unique clinical and pathological manifestation in the gallbladder (2007)
  • 著者名/発表者名: Kuroda N, et. al.
  • 雑誌名: APMIS 115 ページ: 371-375
  • 査読あり
• [雑誌論文] Invasive ductal carcinoma of the breast with signet-ring cell and mucinous carcinoma componets : diagnostic utility of immunocytochemistry of signet-ring cells in aspiration cytology materials. (2007)
  • 著者名/発表者名: Kuroda N, et al.
  • 雑誌名: Diagn Cytopathol 35(3) ページ: 171-173
• [雑誌論文] Anal canal adenocarcinoma with MUC5AC exprssion suggestive of anal gland origin. (2007)
  • 著者名/発表者名: Kuroda N, et al.
  • 雑誌名: Med Mol Morphol 40(1) ページ: 50-53
• [雑誌論文] Hyaline globule-like structures in undifferentiated sarcoma cells of malignat mullerian mixed tumor of the fallopian tube. (2007)
  • 著者名/発表者名: Kuroda N, et al.
  • 雑誌名: Med Mol Morphol 40(1) ページ: 46-49
• [雑誌論文] Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia (2006)
  • 著者名/発表者名: Kuroda N, Mizobuchi M, Shimamura Y, Daibata M, Miyoshi I, Ohara M, Hirouchi T, Mizuno K, Lee G-H.
  • 雑誌名: APMIS 114 ページ: 908-911
  • 査読あり
• [雑誌論文] Askin tumor with metastasis to the scalp : a histochemical, immunohistochemical and ultrastructural study (2006)
  • 著者名/発表者名: Kuroda N, Takahashi T, Moriki T, Okanoue Y, Mizobuchi H, Miyazaki E, Hayashi Y, Lee G-H.
  • 雑誌名: Med Mol Morphol 39 ページ: 221-225
  • 査読あり
• [雑誌論文] Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia. (2006)
  • 著者名/発表者名: Kuroda N, et al.
  • 雑誌名: APMIS 114(12) ページ: 908-911
• [雑誌論文] A skin tumor with metastasis to the scalp : a histochemical,immunohistochemical and ultrastructural study. (2006)
  • 著者名/発表者名: Kuroda N, et al.
  • 雑誌名: Med Mol Morphol 39(4) ページ: 221-225
• [学会発表] マウスを利用した肺発がん感受性の研究 -マウスからヒトへ、ヒトからマウスへ- (2008)
  • 著者名/発表者名: 李康弘、林芳弘
  • 学会等名: 第97回日本病理学会総会
  • 発表場所: 金沢
  • 年月日: 2008-05-16
• [学会発表] マウスを利用した肺発がん感受性の研究 -マウスからヒトヘ、ヒトからマウスヘ- (2008)
  • 著者名/発表者名: 李康弘, 林芳弘
  • 学会等名: 第97回 日本病理学会総会
  • 発表場所: 金沢(石川県立音楽堂)
  • 年月日: 2008-05-16
• [学会発表] Genetic basis for the lung tumor resistance of BALB/cByJ mice (2007)
  • 著者名/発表者名: Lee G-H
  • 学会等名: First JCA-AACR Special Joint Conference
  • 発表場所: Nagoya, Japan