障害心筋におけるエネルギー代謝異常と心筋バイアビリテイ:核医学とMRIによる検討

• 研究課題/領域番号: 18591339
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 放射線科学
• 研究機関: 三重大学
• 研究代表者: 竹田 寛 三重大学, 大学院・医学系研究科, 教授 (70106988)
• 研究分担者: 佐久間 肇 三重大学, 医学部附属病院, 准教授 (60205797) ; 須澤 尚久 三重大学, 医学部附属病院, 医員 (80378372)
• 研究期間 (年度): 2006 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 3,960千円 (直接経費: 3,300千円、間接経費: 660千円); 2008年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円); 2007年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2006年度: 1,100千円 (直接経費: 1,100千円)
• キーワード: 心筋虚血 / 心筋脂肪酸代謝 / 心筋糖代謝 / 心筋血流 / 虚血性心疾患 / 遅延造影MRI / N-13アンモニアPET / F-18 FDG PET / 心筋バイアビリティ / FDG PET / 心臓MRI

研究概要

虚血や薬剤などによる心筋障害を、I-123BMIPPダイナミックSPECT による脂肪酸代謝、FDG-PET による糖代謝、N-13 アンモニアPETによる心筋血流検査、遅延造影MRIによる心筋壊死・線維化の評価などを用いて総合的に検討した。LSO を使用したPET-CT装置は感度とカウントの直線性に優れ、短時間で正確な心筋血流と心筋代謝の計測が可能であった。MRI による梗塞心筋の組織性状に関する情報と核医学による血流・代謝の情報を組み合わせることにより、心筋障害の病態をより正確に評価できる。

研究成果

• [雑誌論文] Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire (2009)
  • 著者名/発表者名: Kurita T, Sakuma H, Onishi K, Ishida M, Kitagawa K, Yamanaka T, Tanigawa T, Kitamura T, Takeda K, Ito M
  • 雑誌名: Eur Heart J. 30 ページ: 444-452
  • 査読あり
• [雑誌論文] Absolute blood contrast concentration and blood signal saturation on myocardial perfusion MRI : estimation from CT data (2009)
  • 著者名/発表者名: shida M, Sakuma H, Murashima S, Nishida J, Senga M, Kobayasi S, Takeda K, Kato N
  • 雑誌名: J Magn Reson Imaging 29 ページ: 205-210
  • 査読あり
• [雑誌論文] Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : a multicenter study (2008)
  • 著者名/発表者名: Kitagawa K, Sakuma H, Nagata M, Okuda S, Hirano M, Tanimoto A, Matsusako M, Lima JA, Kuribayashi S, Takeda K.
  • 雑誌名: Eur Radiol 18 ページ: 2808-2816
  • 査読あり
• [雑誌論文] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging (2008)
  • 著者名/発表者名: Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H.
  • 雑誌名: Circ J 72 ページ: 378-383
  • NAID: 110006646489
  • 査読あり
• [雑誌論文] Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : a multicenter study. (2008)
  • 著者名/発表者名: Kitagawa K, Sakuma H, Nagata M, Okuda S, Hirano M, Tanimoto A, Matsusako M, Lima JA, Kuribayashi S, Takeda K.
  • 雑誌名: Eur Radiol. 18 ページ: 2808-2816
  • 査読あり
• [雑誌論文] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomvopathy assessed by magnetic resonance imaging. (2008)
  • 著者名/発表者名: Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H.
  • 雑誌名: Circ J. 72 ページ: 378-383
  • 査読あり
• [雑誌論文] Quantitative analysis of first-pass contrast-enhanced myocardial perfusion MRI using a patlak plot method and blood saturation correction (2007)
  • 著者名/発表者名: Ichihara T, Ishida M, Kitagawa K, Ichikawa Y, atsume T, Yamaki N, Maeda H, Takeda K, Sakuma H
  • 雑誌名: Magn Reson Med (Epub ahead of print)
  • 査読あり
• [雑誌論文] Diagnostic value of late gadolinium-enhanced MRI and first-pass dynamic MRI for predicting functional recovery in patients after acute myocardial infarction (2007)
  • 著者名/発表者名: Kitagawa K, Ichikawa Y, Hirano T, Makino K, Kobayashi S, Takeda K, Sakuma H.
  • 雑誌名: Radiat Med 25 ページ: 263-271
  • NAID: 10019726666
  • 査読あり
• [学会発表] Quantification of Rest and Stress Myocardial Blood Flow with Prospectively Gated Dynamic Multi-slice CT : Comparison with 13N-ammonium Myocardial Perfusion PET (2008)
  • 著者名/発表者名: Ishida M, Sakuma H, Nagata M, Ishida N, Ichihara T, Nakajima H, Ito M, Takeda K.
  • 学会等名: 93th RSNA
  • 発表場所: Chicago
• [学会発表] Subendmyocardial Perfusion Reserve Correlated with Left Ventricular Diastolic Function in Patients with Various Types of Left Ventricular Hypertrophy (2008)
  • 著者名/発表者名: Kurita T, Onishi K, Sakuma H, Takamura T, Nagata M, Nakajima H, Ishida M, Fujimoto N, Dohi K, Takeda K, Ito M.
  • 学会等名: AHA scientific sessions2008
  • 発表場所: New Orleans
• [学会発表] Adenosine-stress CT Myocardial Perfusion Imaging : Comparison with Stress Myocardial Perfusion MRI in Patients with Coronary Artery Disease (2008)
  • 著者名/発表者名: Ishida M, Sakuma H, Kato S, Nagata M, Ishida N, Nakamura M, Nakajima H, Ito M, Takeda K.
  • 学会等名: AHA scientific sessions 2008
  • 発表場所: New Orleans
• [学会発表] Absolute quantification of myocardial blood flow from rest perfusion MRI can provide improved sensitivity for predicting myocardial viability in patients early after myocardial infarction (2008)
  • 著者名/発表者名: Nagata M, Sakuma H, Kurita T, Ishida N, Ishida M, Mikami Y, Nakajima H, Ito M, Takeda K.
  • 学会等名: ECR
  • 発表場所: Vienna, Austria
• [学会発表] Quantification of Rest and Stress Myocardial Blood Flow with Prospectively Gated Dynamic Multi-slice CT : Comparison with 13N-ammonium Myocardial Perfusion PET. (2008)
  • 著者名/発表者名: Ishida M, Sakuma H, Nagata M, Ishida N, Ichihara T, Nakajima H, Ito M, Takeda K
  • 学会等名: 第93回北米放射線学会
  • 発表場所: Chicago
• [学会発表] Rest and stress myocardial blood flow (MBF) measured by fully quantitative analysis of first-pass perfusion MRI showed good agreement with rest and stress MBF by radio-water PET (2007)
  • 著者名/発表者名: Ishida M, Sakuma H, Nagata M,Ishida N, Mikami Y, Ichihara T, Maeda H,Goko Y, Parkka J, Kunuuti J, Haltiala J, Takeda K.
  • 学会等名: 92th RSNA
  • 発表場所: Chicago
• [学会発表] Long Term Prognostic Value of Stress Perfusion CMR and Late Gadolinium Enhanced CMR for The Prediction of Major Adverse Cardiac Events (2007)
  • 著者名/発表者名: Kurita T, Sakuma H, Onishi K, Nagata M, Takamura T, Ishida M, Fujimoto N, Dohi k, Takeda K, Ito M.
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
• [学会発表] Absolute Quantification of Rest Myocardial Blood Flow by Cardiac Magnetic Resonance can provide Improved Prediction of Functional Recovery in Patients with Acute Myocardial Infarction (2007)
  • 著者名/発表者名: Kurita T, Sakuma H, Nagata M, Ishida M, Tanigawa T, Onishi K, Isaka N, Takeda K, Ito M
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
• [学会発表] Myocardial Perfusion Reserve Determined by Model Based Quantitative Analysis of Stress-Rest Perfusion MRI Permits Improved Accuracy in Predicting Coronary Artery Diseases When Compared with Semiquantitative Analysis (2007)
  • 著者名/発表者名: Ishida M, Sakuma H, Shi Y, Nagata M, Ishida N, Mikami Y, Ichihara T, Maeda H, Goko Y, Kurita T, Ito M, Takeda K
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
• [学会発表] Comparison between Radio-water PET and Model Based Quantitative Analysis of Myocardial Perfusion Magnetic Resonance (2007)
  • 著者名/発表者名: Ishida M, Parkka JP, Sakuma H, Nagata M, Ishida N, Mikami Y, Ichihara T, Takeda K, Maeda H, Goko Y, Kunuuti J, Hartiala JJ
  • 学会等名: AHA scientific sessions 2007
  • 発表場所: Orlando
• [学会発表] Absolute quantification of myocardial blood flow in patients with acute myocardial infarction after successful percutaneous coronary interventions (2007)
  • 著者名/発表者名: Nagata M, Sakuma H, Ishida M, Kurita T, Ishida N, Tanigawa T, Onishi K, Ichihara T, Ito M, Takeda K
  • 学会等名: 15th ISMRM
  • 発表場所: Berlin
• [学会発表] Absolute Quantification of Myocardial Blood Flow Using First-Pass Perfusion MRI : Extraction Fraction of Gd-DTPA Varies with Myocardial Blood Flow in Human Myocardium (2007)
  • 著者名/発表者名: Ishida M, Sakuma H, Ichihara T, Goko Y, Ishida N, Nagata M, Kitagawa K, Maeda H, Kurita T, Teraoka K, Takeda K
  • 学会等名: 15th ISMRM
  • 発表場所: Berlin