生後発達に伴う脊髄痛覚伝達系成熟過程のin vivoパッチクランプ解析

• 研究課題/領域番号: 18613009
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 疼痛学
• 研究機関: 九州大学
• 研究代表者: 古江 秀昌 九州大学, 大学院・医学研究院, 助教 (20304884)
• 研究分担者: 吉村 恵 九州大学, 大学院・医学研究院, 教授 (10140641)
• 研究期間 (年度): 2006 – 2007
• 研究課題ステータス: 完了 (2007年度)
• 配分額: 4,090千円 (直接経費: 3,700千円、間接経費: 390千円); 2007年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2006年度: 2,400千円 (直接経費: 2,400千円)
• キーワード: 生後発達 / 神経回路 / 痛覚 / シナプス / 神経生理 / アロディニア / in vivoパッチクランプ / 形成と再生 / パッチクランプ / in vivo / 感覚 / 痛覚伝達 / 電気生理 / 脊髄

研究概要

生後発達に伴って脊髄痛覚回路の形成および機能確立が如何にして行われるかを明らかにするために、幼若および成熟ラット、発達に伴う脊髄への一次求心性線維の投射に重要な役割を果たす分子を欠損したマウスに誘起される脊髄感覚シナプス応答をスライスおよびin vivoパッチクランプ法を用いて解析した。1) 成熟ラットでは、痛みの伝達やその調節に重要な役割を果たす脊髄後角表層、膠様質において、Aδ線維やC線維を介した単シナプス性の興奮性シナプス後電流(EPSC)が観察された。後角深層細胞では主に、Aβ線維を介した単シナプス性EPSCが誘起された。一方、幼若ラットでは、Aδ線維やC線維の入力に加え、多くの細胞でAβ線維を介した単シナプス性EPSCが見られた。2) 幼若および成熟ラットにおける膠様細胞はともに機械的侵害刺激に対してEPSCの発生頻度と振幅が著明に増大した。成熟ラット深層細胞は主に触刺激によってEPSCを発生した。一方、Aβ線維からの単シナプス性入力のみを受ける幼若ラット膠様質細胞においても、機械的侵害刺激によってEPSCの発生頻度と振幅が著明に増大した。3) 欠損マウス脊髄では、AδやC線維の単シナプス性入力に加え、単シナプス性のAβ線維の入力が脊髄浅層細胞において観察された。さらに、脊髄深層ではAβ線維の単シナプス性入力が減弱した。機械的侵害刺激に対する逃避行動の閾値が正常より有意に減少した。
以上より、幼若期ではAδ線維やC線維に加えAβ線維が脊髄膠様質に興奮性にシナプス入力し、機械的痛み情報を伝達する、成熟に伴ってAδ線維やC線維のみが膠様質に痛みを伝え、Aβ線維は後角深層に触を伝える、即ち、線維選択性に洗練された痛覚回路が形成される事、また、欠損マウスでは触覚情報が痛覚回路へ誤入力し、触によって逃避行動を示す異痛症(アロディニア)を呈することが明らかになった。

研究成果

• [雑誌論文] Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 雑誌名: Journal of Neuroscience 27 ページ: 3466-3476
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro (2007)
  • 著者名/発表者名: Yasaka T., et. al.
  • 雑誌名: Journal of Physiology(London) 581(2) ページ: 603-618
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensensory cortical neurons:in vivo patch-clamp analysis (2007)
  • 著者名/発表者名: DoiA., et. al.
  • 雑誌名: European Journal of Neuroscience 26(9) ページ: 2565-2575
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor (2007)
  • 著者名/発表者名: Tsuda M, et. al.
  • 雑誌名: Journal of Neurochemistry 102(5) ページ: 1658-1668
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Electrophysiological analysis of plastic changes in nociceptive transmission (2007)
  • 著者名/発表者名: Furue H, et. al.
  • 雑誌名: ペインクリニック 28(1) ページ: 93-105
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] The role of GABA_B receptor in spinal nociceptive transmission (2007)
  • 著者名/発表者名: Takeshima K, et. al.
  • 雑誌名: Pain Research 22 ページ: 33-41
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Function of spinal GABA receptor and its modulation (2007)
  • 著者名/発表者名: Yoshimura M, et. al.
  • 雑誌名: 麻酔 56
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Recent insights into mechanisms for analgesic effect by calcitonin (2007)
  • 著者名/発表者名: Ito A, et. al.
  • 雑誌名: 日本臨床 65(S9) ページ: 386-390
  • 説明: 「研究成果報告書概要(和文)」より
• [雑誌論文] Cadherin-8 is Required for the First Relay Synapses to Receive Functional Inputs from Primary Sensory Afferents for Cold Sensation (2007)
  • 著者名/発表者名: Fume, H., Suzuki,SC.,Koga, K., Jiang, N., Nohmi,M., Shimazaki,Y., Katoh-Fukui,Y., Yokoyama,M., Yoshimura, M.,Takeichi M.
  • 雑誌名: Journal of Neuroscience 27 ページ: 3466-3476
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro. (2007)
  • 著者名/発表者名: Yasaka,T., Kato, G., Fume,H., Rashid,MH., Sonohata,M., Tamae,A., Murata,Y., Masriko,S., Yoshimura M.
  • 雑誌名: Journal of Physiology(London) 581(2) ページ: 603-618
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons : in vivo patch-clamp analysis (2007)
  • 著者名/発表者名: Doi,A., Mizuno, M.,Katafuchi,T., Fume, H., Koga, K., YoshimuraM.
  • 雑誌名: European Journal of Neuroscience 26(9) ページ: 2565-2575
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor (2007)
  • 著者名/発表者名: Tsuda, M., Ishii,S., Masuda,T., Hasegawa,S., K., Nakamura, Nagata, K., Yamashita,T., Fume,H., Tozaki-Saitoh,H., Yoshimura,M., Koizumi, S., Shimizu, K., Inoue T
  • 雑誌名: Journal of Neurochemistry 102(5) ページ: 1658-1668
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Electrophysiological analysis of plastic changes in nociceptive transmission (2007)
  • 著者名/発表者名: Fume,H., Yoshimura M.
  • 雑誌名: Pain Clinic 28(1) ページ: 93-105
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] The role of GABAB receptor in spinal nociceptive transmission (2007)
  • 著者名/発表者名: Takeshima, K., Fume, H., Yoshimura M.
  • 雑誌名: pain Research 22 ページ: 33-41
  • NAID: 10018864244
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Function of spinal GABA receptor and its modulation. (2007)
  • 著者名/発表者名: Yoshimura, M., Fume, H., Takazawa, T., Kohno, T., Takeshima, K
  • 雑誌名: Masui 56
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Recent insights into mechanisms for analgesic effect by calcitonin. (2007)
  • 著者名/発表者名: Ito, A., Fume, H., Yoshimura, M
  • 雑誌名: Nippon Rinsho 65(S9) ページ: 386-390
  • NAID: 40015709895
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] In vivo patch-clamp technique. (2007)
  • 著者名/発表者名: H., Fume, T., Katafuchi, M., Yoshimura
  • 雑誌名: Patch-Clamp Analysis : advanced techniques, Second Edition. Ed.(W., Walz)(Humana Press Inc., Totowa) ページ: 229-251
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Cadherin-8 is required for the first relay synapses to receive functional inputsfrom primary sensory afferents for cold sensation (2007)
  • 著者名/発表者名: Furue H, et. al.
  • 雑誌名: Journal of Neuroscience 27 ページ: 3466-3476
  • 査読あり
• [雑誌論文] Cell type specific excitatory and inhibitory circuits involving primary afferentsin the substantia gelatinosa of the rat spinal dorsal horn in vitro (2007)
  • 著者名/発表者名: Yasaka T, et. al.
  • 雑誌名: Journal of Physiology(London) 581(2) ページ: 603-618
  • 査読あり
• [雑誌論文] Slow oscillation of membrane currents mediated by glutamatergic inputs of ratsomatosensory cortical neurons:in vivo patch-clamp analysis (2007)
  • 著者名/発表者名: Doi A, et. al.
  • 雑誌名: European Journal of Neuroscience 26(9) ページ: 2565-2575
  • 査読あり
• [雑誌論文] Reduced pain behaviors and extracellular signal-related protein kinase activation in primarysensory neurons by peripheral tissue in micclacking platelet-activaing factor receptor (2007)
  • 著者名/発表者名: Tsuda M, et. al.
  • 雑誌名: Journal of Neurochemistry 102(5) ページ: 1658-1668
  • 査読あり
• [雑誌論文] Cadherin-8 is Required for the First Relay Synapses to Receive Functional Inputs from Primary Sensory Afferents for Cold Sensation, (2007)
  • 著者名/発表者名: Furue H. et al.
  • 雑誌名: Journal of Neuroscience 27 ページ: 3466-3476
• [雑誌論文] Involvement of Kv channel subtypes on GABA release in mechanically dissociated neurons from the rat substantia nigra. (2007)
  • 著者名/発表者名: Shimada H. et al.
  • 雑誌名: Brain Research 1141 ページ: 74-83
• [雑誌論文] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro. (2007)
  • 著者名/発表者名: Yasaka T. et al.
  • 雑誌名: Journal of Physiology (London) in press
• [雑誌論文] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors (2006)
  • 著者名/発表者名: Shiokawa H., et. al.
  • 雑誌名: Journal of Physiology(London) 573(Pt3) ページ: 753-763
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the apinal cord in mice (2006)
  • 著者名/発表者名: Rashid MH., et. al.
  • 雑誌名: Pain 125(1-2) ページ: 125-135
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Mechanisms for the Anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord (2006)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 雑誌名: Journal of Pharmacological Sciences 101 ページ: 107-117
  • NAID: 10018237576
  • 説明: 「研究成果報告書概要(和文)」より
  • 査読あり
• [雑誌論文] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors (2006)
  • 著者名/発表者名: Shiokawa,H., Nakatsuka, T., Furue, H., Tsuda,M., Katafuchi,T., Inoue, K., Yoshimura M.
  • 雑誌名: Journal of Physiology(London) 573(Pt3) ページ: 753-763
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice (2006)
  • 著者名/発表者名: Rashid, MH., Furue,H., Yoshimura, M., UedaH
  • 雑誌名: Pain 125(1-2) ページ: 125-135
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Mechanisms for the Anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord (2006)
  • 著者名/発表者名: Yoshimura,M., FurueH
  • 雑誌名: Journal Pharmacological Sciences 101 ページ: 107-117
  • NAID: 10018237576
  • 説明: 「研究成果報告書概要(欧文)」より
• [雑誌論文] Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. (2006)
  • 著者名/発表者名: Kato G.et al.
  • 雑誌名: Journal of Neuroscience 26・6 ページ: 1787-1794
• [雑誌論文] Chariges in properties of substantia gelatinosa neurons after surgical incision in the rat : In vivo patch-clamp analysis. (2006)
  • 著者名/発表者名: Kawamata M. et al.
  • 雑誌名: Anesthesiology 104 ページ: 432-440
• [雑誌論文] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors. (2006)
  • 著者名/発表者名: Shiokawa H. et al.
  • 雑誌名: Journal of Physiology (London) 573.3 ページ: 753-763
• [雑誌論文] Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice. (2006)
  • 著者名/発表者名: Rashid MH. et al.
  • 雑誌名: Pain 125・1-2 ページ: 125-135
• [雑誌論文] Mechanisms for the Anti-nociceptve Actions of the Descending Noradrenergic and Serotonergic Systems in the Spinal Cord. (2006)
  • 著者名/発表者名: Yoshimura M. et al.
  • 雑誌名: Journal Pharmacological Sciences 101 ページ: 107-117
• [学会発表] Increased mechanical synaptic inputs to the rat spinal dorsal horn in vivo (2008)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Selective modulation of excitatory synaptic transmission in excitatory interneurons in the adult rat spinal dorsal horn through TRPA1 agonist-sensitive C fibres (2008)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo intracellular recording analysis of itch signal transduction in rat dorsal root ganglion cells (2008)
  • 著者名/発表者名: Hachisuka J., et. al.
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Increased mechanical synaptic inputs o the rat spinal dorsal horn in vivo following inflammation. (2008)
  • 著者名/発表者名: H., Fume, J., Hachisuka, M., Yoshimura
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Selective modulation of excitatory synaptic transmission in excitatory intemeurons in the adult rat spinal dorsal horn through TRPA1 agonist-sensitive C fibres. (2008)
  • 著者名/発表者名: D., Uta, H., Fume, M., Yoshimura
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo intracellular recording analysis of itch signal transduction in rat dorsal root ganglion cells. (2008)
  • 著者名/発表者名: J., Hachisuka, H., Fume, M., Fume, M., Yoshimura
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Increased mechanical synaptic inputs to the rat spinal dorsal horn in vivo following inflammation (2008)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] Selective modulation of excitatory synaptic transmission in excitatory interneuronsin the adult rat spinal dorsal horn through TRPA l agonist-sensitive C fibres (2008)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] In vivo intracellular recording analysis of action potentials elicited by5-HT-induced itch stimuli in rat dorsal root ganglion neurons (2008)
  • 著者名/発表者名: Hachisuka J., et. al.
  • 学会等名: The 85th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Tokyo, Japan
• [学会発表] In vivo intracellular recording analysis of action potentials elicited by 5-HT-induced itch stimuli in rat dorsal root ganglion neurons (2007)
  • 著者名/発表者名: Hachisuka J., et. al.
  • 学会等名: 17th International Symposium of Itch
  • 発表場所: Osaka,Japan
  • 年月日: 2007-09-15
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo intracellular recording analysis of action potentials elicited by 5-HT-induced itch stimuli in rat dorsal root ganglion neurons (2007)
  • 著者名/発表者名: J., Hachisuka, H., Fume, M., Fume, M., Yoshimura
  • 学会等名: 17th International Symposium of Itch
  • 発表場所: Osaka, Japan
  • 年月日: 2007-09-15
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo intracellular recording analysis of action potentials elicited by5-HT-induced itch stimuli in rat dorsal root ganglion neurons (2007)
  • 著者名/発表者名: Hachisuka J., et. al.
  • 学会等名: 17th International Symposium of Itch
  • 発表場所: Osaka, Japan
  • 年月日: 2007-09-15
• [学会発表] Activation of TRPAl reduces C afferent-evoked excitatory synaptic transmission but enhances the miniature release in substantia gelatinosa of the adult rat spinal cord (2007)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 29th Annual Meeting of JASP
  • 発表場所: Yokohama,Japan
  • 年月日: 2007-07-07
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Electrophysiological analysis of effects of Neurotropin on serotonergic neurons in the Nucleus Raphe Magnus (2007)
  • 著者名/発表者名: Okai H., et. al.
  • 学会等名: The 29th Annual Meeting of JASP
  • 発表場所: Yokohama,Japan
  • 年月日: 2007-07-07
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Activation of TRPA1 reduces C afferent-evoked excitatory synaptic transmission but enhances the miniature release in substantia gelatinosa of the adult rat spinal cord. (2007)
  • 著者名/発表者名: D., Uta, MH., Rashid, H., Fume, M., Yoshimura
  • 学会等名: The 29th Annual Meeting of JASP
  • 発表場所: Yokohama, Japan
  • 年月日: 2007-07-07
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Electrophysiological analysis of effects of Neurotropin on serotonergic neurons in the Nucleus Raphe Magnus. (2007)
  • 著者名/発表者名: H., Okai, H., Fume, M., Yoshimura
  • 学会等名: The 29th Annual Meeting of JASP
  • 発表場所: Yokohama, Japan
  • 年月日: 2007-07-07
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Activation of TRPA1 reduces C afferent-evoked excitatory synaptic transmission but enhances theminiature release in substantia gelatinosa of the adult rat spinal cord (2007)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 29th Annual Meeting of JASP
  • 発表場所: Yokohama, Japan
  • 年月日: 2007-07-07
• [学会発表] Electrophysiological analysis of effects of Neurotropin on serotonergic neuronsin the Nucleus Raphe Magnus (2007)
  • 著者名/発表者名: Okai H., et. al.
  • 学会等名: The 29th Annual Meeting of JASP
  • 発表場所: Yokohama, Japan
  • 年月日: 2007-07-07
• [学会発表] Analogy of A-beta afferents termination in pathological conditions with immature state (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: Second International Congress on Neuropathic Pain
  • 発表場所: Berlin,Germany
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Modification of bursting activities in somatosensory cortex in inflamed-rats in vivo (2007)
  • 著者名/発表者名: Koga K., et. al.
  • 学会等名: Second International Congress on Neuropathic Pain
  • 発表場所: Berlin,Germany
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo and slice patch-clamp analyses of plastic changes indescending inhibition of spinal noxious mechanical synaptic transmission in ovariectomized rats (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Increased noxious mechanical synaptic inputs to the rat spinal dorsal horn from A delta and C fibers:in vivo patch-clamp and intracellular recordings from spinal and dorsal root ganglion neurons (2007)
  • 著者名/発表者名: Hachisuka J., et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Electrophysiological and morphological analyzes of excitatory effect of TRPAl agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Cortical membrane potential fluctuations may be modified by thalamocortical inputs in rat barrel cortex in vivo (2007)
  • 著者名/発表者名: Mizuno M., et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Modulation of sensory inputs from inflamed region to the primary sensory cortex (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 2nd International Symposium on Design of Artificial Environments
  • 発表場所: Fukuoka,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Functional loss of synaptic inputs to spinal superficial dorsal horn neurons through cold-sensitive afferent fibers in cadherin-8 deficient mice (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • 発表場所: Sendai,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Reduction of menthol-sensitive afferent inputs to superficial dorsa neurons in knockout mice of cadherin-8 (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 84th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Osaka,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Analogy of A-beta afferent sprouting in inflamed rats with sensory circuit in developing spinal dorsal horn (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 84th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Osaka,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Excitatory effect of TRPAl agonists on noxious transmission in substantia gelatinosa neurons of the rat spinal cord (2007)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 84th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Osaka,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Functional role pf GABA receptor and its modification in the spinal dorsal horn (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 54th Annual Meeting of Japanese Society of Anesthesiologists
  • 発表場所: Sapporo,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelatinosa neurons of the rat spinal dorsal horn through cadherin-8 expressing synaptic glomeruli (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Plastic modification of TRP channel activities in the spinal dorsal horn following peripheral nerve injury (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo patch-clamp analysis of plastic changs in descending serotonergic inhibition of noxious mechanical transmission to substantia gelatinosa neurons through 5-HTIA receptors in ovariectomized rats (2007)
  • 著者名/発表者名: Omori Y., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Patch-clamp analysis of membrane propreties of bursting neurons in the young adult rat ventral horn in vitro (2007)
  • 著者名/発表者名: Hisamitsu R., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo patch clamp analysis of synaptic responses evoked in primary somatosensory cortex in inflamed rats (2007)
  • 著者名/発表者名: Koga K., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain (2007)
  • 著者名/発表者名: Yanagisawa Y., et. al.
  • 学会等名: The 22nd Annual Research Meeting of the Japanese Orthopaedic Association
  • 発表場所: Shizuoka,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Central sensitization induced switching of subunit in AMPA receptor following inflammatory pain (2007)
  • 著者名/発表者名: Katano T., et. al.
  • 学会等名: The 30th Annual Meeting of the Molecular Biology Society of Japan and The 80th Annual Meeting of the Japanese Biochemical Society
  • 発表場所: Yokohama,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Analogy of A-beta afferents termination in pathological conditions with immature state. (2007)
  • 著者名/発表者名: M., Yoshimura, T., Nakatsuka, H., Fume
  • 学会等名: Second International Congress on Neuropathic Pain
  • 発表場所: Berlin, Germany
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Modification of bursting activities in somatosensory cortex in inflamed -rats in vivo. (2007)
  • 著者名/発表者名: K., Koga, H., Shiokawa, M., Mizuno, A., Doi, H., Takase-Mizuguchi, H., Fume, M., Yoshimura
  • 学会等名: Second International Congress on Neuropathic Pain
  • 発表場所: Berlin, Germany
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo and slice patch-clamp analyses of plastic changes in descending inhibition of spinal noxious mechanical synaptic transmission in ovariectomized rats. (2007)
  • 著者名/発表者名: H., Fume, Y., Omori, A., Ito, Y., Kuraishi, M., Yoshimura
  • 学会等名: The 37th Annual Meeting of the Society for Neuroscience
  • 発表場所: San Diego, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Increased noxious mechanical synaptic inputs to the rat spinal dorsal horn from A delta and C fibers : in vivo patch-clamp and intracellular recordings from spinal and dorsal soot ganglion neurons. (2007)
  • 著者名/発表者名: J., Hachisuka, H., Fume, M., Yoshimura
  • 学会等名: The 37th Annual Meeting of the Society for Neuroscience
  • 発表場所: San Diego, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Electrophysiological and morphological analyzes of excitatory effect of TRPA1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. (2007)
  • 著者名/発表者名: D., Uta, MH., Rashid, H., Fume, R., Hisamitsu, M., Yoshimura
  • 学会等名: The 37th Annual Meeting of the Society for Neuroscience
  • 発表場所: San Diego, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Cortical membrane potential fluctuations may be modified by thalamocortical inputs in rat barrel cortex in vivo. (2007)
  • 著者名/発表者名: M., Mizuno, A., Doi, T., Yasaka, H., Fume, S., Aou, M., Yoshimura
  • 学会等名: The 37th Annual Meeting of the Society for Neuroscience
  • 発表場所: San Diego, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Modulation of sensory inputs from inflamed region to the primary sensory cortex. (2007)
  • 著者名/発表者名: M., Yoshimura, K., Koga, H., Fume
  • 学会等名: The 2nd International Symposium on Design of Artificial Environments
  • 発表場所: Fnknnka Janan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Functional loss of synaptic inputs to spinal superficial dorsal horn neurons through cold-sensitive afferent fibers in cadherin-8 deficient mice. (2007)
  • 著者名/発表者名: H., Fume, M., Yoshimura
  • 学会等名: The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • 発表場所: Sendai, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Reduction of menthol-sensitive afferent inputs to superficial dorsa neurons in knockout mice of cadherin-8. (2007)
  • 著者名/発表者名: H., Fume, S., Suzuki, K., Koga, Y., Shimazaki, M., Nohmi, M., Takeichi, M., Yoshimura
  • 学会等名: The 84th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Osaka, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Analogy of A-beta afferent sprouting in inflamed rats with sensory circuit in developing spinal dorsal horn. (2007)
  • 著者名/発表者名: M., Yoshimura, H., Fume, S., Matayoshi, T., Nakatsuka, T., Katafuchi
  • 学会等名: The 84th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Osaka, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Excitatory effect of TRPAI agonists on noxious transmission in substantia gelatinosa neurons of the rat spinal cord. (2007)
  • 著者名/発表者名: D., Uta, MH., Rashid, H., Fume, M., Yoshimura
  • 学会等名: The 84th Annual Meeting of the Physiological Society of Japan
  • 発表場所: Osaka, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Functional role pf GABA receptor and its modification in the spinal dorsal horn. (2007)
  • 著者名/発表者名: M., Yoshimura, T., Takazawa, T., Kohno, H., Fume, K., Koga
  • 学会等名: The 54th Annual Meeting of Japanese Society of Anesthesiologists
  • 発表場所: Sapporo, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelatinosa neurons of the rat spinal dorsal horn through cadherin-8 expressing synaptic glomeruli. (2007)
  • 著者名/発表者名: H., Fume, SC., Suzuki, K., Koga, M., Nohmi, M., Takeichi, M., Yoshimura
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Plastic modification of TRP channel activities in the spinal dorsal horn following peripheral nerve injury. (2007)
  • 著者名/発表者名: M., Yoshimura, H., Fume
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo patch-clamp analysis of plastic changes in descending serotonergic inhibition of noxious mechanical transmission to substantia gelatinosa neurons through 5-HT1A receptors in ovariectomized rats. (2007)
  • 著者名/発表者名: Y., Omori, H., Fume, A., Ito, Y., Kuraishi, M., Yoshimura
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Patch-clamp analysis of membrane properties of bursting neurons in the young adult rat ventral horn in vitro. (2007)
  • 著者名/発表者名: R., Hisamitsu, H., Fume, M., Yoshimura
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo patch clamp analysis of synaptic responses evoked in primary somatosensory cortex in inflamed rats. (2007)
  • 著者名/発表者名: K., Koga, H., Shiokawa, M., Mizuno, A., Doi, H., Takase-Mizuguchi, H., Fume, M., Yoshimura
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain. (2007)
  • 著者名/発表者名: Y., Yanagisawa, H., Fume, T., Kawamata, A., Namiki, Y., Iwamoto, M., Yoshimura
  • 学会等名: The 22nd Annual Research Meeting of the Japanese Orthopaedic Association
  • 発表場所: Shizuoka, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Central sensitization induced by switching of subunit in AMPA receptor following inflammatory pain. (2007)
  • 著者名/発表者名: T., Katano, H., Fume, M., Tagatani, E., Ashitaka, M., Yoshimura, S., Ito
  • 学会等名: The 30th Annual Meeting of the Molecular Biology Society of Japan and The 80th Annual Meeting of the Japanese Biochemical Society
  • 発表場所: Yokohama, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Analogy of A-beta afferents termination in pathological conditions withimmature state (2007)
  • 著者名/発表者名: Yoshimura M, et. al.
  • 学会等名: Second International Congress on Neuropathic Pain
  • 発表場所: Berlin, Germany
• [学会発表] Modification of bursting activities in somatosensory cortex in inflamed-rats in vivo (2007)
  • 著者名/発表者名: Koga K, et. al.
  • 学会等名: Second International Congress on Neuropathic Pain
  • 発表場所: Berlin, Germany
• [学会発表] In vivo and slice patch-clamp analyses of plastic changes in descending inhibition of spinal noxious mechanical synaptic transmission inovariectomized rats (2007)
  • 著者名/発表者名: Furue H, et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego, USA
• [学会発表] Increased noxious mechanical synaptic inputs to the rat spinal dorsal horn from A deltaand C fibers:in vivo patch-clamp and intracellular recordings from spinal and dorsalroot ganeglion neurons (2007)
  • 著者名/発表者名: Hachisuka J., et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego, USA
• [学会発表] Electrophysiological and morphological analyzes of excitatory effect of TRPA1agonists on synaptictransmission in substantia gelatinosa neurons ofthe adult rat spinalcord (2007)
  • 著者名/発表者名: Uta D, et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego, USA
• [学会発表] Cortical membrane potential fluctuations may be modified by thalamocorticalinputs in rat barrel cortex in vivo (2007)
  • 著者名/発表者名: Mizuno M., et. al.
  • 学会等名: The 37th Annual Meeting of Society for Neuroscience
  • 発表場所: San Diego, USA
• [学会発表] Modulation of sensory inputs from inflamed region to the primary sensorycortex (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 2nd International Symposium on Design ofArtificial Environments
  • 発表場所: Fukuoka, Japan
• [学会発表] Functional loss of synaptic inputs to spinal superficial dorsal horn neuronsthrough cold-sensitiveafferent fibers in cadherin-8 deficient mice (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 7th Japan-Korea Joint Symposium of BrainSciences, and Cardiac and Smooth Muscles
  • 発表場所: Sendai, Japan
• [学会発表] Functional role pf GABA receptor and its modification in the spinal dorsalhorn (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 54th Annual Meeting of japanese Society of Anesthesiologists
  • 発表場所: Sapporo, Japan
• [学会発表] Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelatinosaneurons of the rat spinal dorsal horn through cadherin-8 expressing synaptic glomeruli (2007)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
• [学会発表] Plastic modification of TRP channel activities in the spinal dorsal hornfollowing peripheral nerve injury (2007)
  • 著者名/発表者名: Yoshimura M., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
• [学会発表] In vivo patch-clamp analysis of plastic changes in descending serotonergic inhibition ofnoxious mechanical transmission to substantia gelatinosa neurons through 5-HT1Areceptors in ovariectomized rats (2007)
  • 著者名/発表者名: Omori Y., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
• [学会発表] Patch-clamp analysis of membrane properties of bursting neurons in the youngadult rat ventral horn in vitro (2007)
  • 著者名/発表者名: Hisamitsu R., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
• [学会発表] In vivo patch clamp analysis of synaptic responses evoked in primarysomatosensory cortex in inflamed rats (2007)
  • 著者名/発表者名: Koga K., et. al.
  • 学会等名: The 30th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Yokohama, Japan
• [学会発表] Behavioral and electrophysiological analyses of spinaltransmission in a murine model of cancer-induced bone pain (2007)
  • 著者名/発表者名: Yanagisawa Y., et. al.
  • 学会等名: The 22nd Annual Research Meeting of the JapaneseOrthopaedic Association
  • 発表場所: Shizuoka, Japan
• [学会発表] Central sensitization induced by switching of subunit in AMPA receptorfollowing inflammatory pain (2007)
  • 著者名/発表者名: Katano T., et. al.
  • 学会等名: The 30th Annual Meeting of the Molecular Biology Societyof Japan and The 80th Annual Meeting of the JapaneseBiochemical Socie
  • 発表場所: Yokohama, Japan
• [学会発表] Functional loss of synaptic inputs to substantia gelatinosa neurons in the spinal cord through menthol-sensitive afferent fibers in cadherin-8 deficient mice (2006)
  • 著者名/発表者名: Furue H., et. al.
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Cadherin-8 regulates activities of the first relay synapse for cool sensation (2006)
  • 著者名/発表者名: Suzuki S., et. al.
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Actions of agonists for the noxious cold ion channel TRPA1 in synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2006)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo patch-clamp analysis of GABA_B receptor-mediated inhibitory effects on noxious and innocuous mechanical synaptic transmission in substantia gelarinosa neurons of the rat spinal cord (2006)
  • 著者名/発表者名: Takeshima K., et. al.
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Whole-cell patch-clamp analusis of firing patterns of ventral horn neurons in young adult rat in vitro (2006)
  • 著者名/発表者名: Hisamitsu R., et. al.
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta,USA
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] In vivo patch-clamp analysis of effects of bacrofen on noxious and innocuous synaptic transmission in substantia gelarinosa neurons of the rat spinal cord (2006)
  • 著者名/発表者名: Takeshima K., et. al.
  • 学会等名: The 28th Annual Meeting of JASP
  • 発表場所: Kobe,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Physiological properties of substantia gelatinosa neurons in neonatal rats by in vivo patch-clamp analysis (2006)
  • 著者名/発表者名: Kawamata M., et. al.
  • 学会等名: The 28th Annual Meeting of JASP
  • 発表場所: Kobe,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Actions of serotonin on nociceptive transmission in the substantia gelatinosa of the rat spinal cord (2006)
  • 著者名/発表者名: Abe K., et. al.
  • 学会等名: The 29th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Kobe,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Actions of local anesthetics on primary afferent synaptic transmission to the substantia gelatinosa of the rat spinal cord (2006)
  • 著者名/発表者名: Uta D., et. al.
  • 学会等名: The 29th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Kobe,Japan
  • 説明: 「研究成果報告書概要(和文)」より
• [学会発表] Functional loss of synaptic inputs to substantia gelatinosa neurons in the spinal cord through menthol-sensitive afferent fibers in cadherin-8 deficient mice. (2006)
  • 著者名/発表者名: Fume, H., Suzuki, S., Koga, K., Jiang, N., Nohmi, M., Takeichi, M., Yoshimura, M.
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Cadherin-8 regulates activities of the first relay synapse for cool sensation. (2006)
  • 著者名/発表者名: Suzuki, H., Fume, H., Koga, K., Jiang, N., Nohmi, M., Yoshimura, M., Takeichi, M
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Actions of agonists for the noxious cold ion channel TRPAI in synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. (2006)
  • 著者名/発表者名: Uta, D., Rashid, MH., Furue, H., Katafuchi, T., Hisamitsu, R., Shimada, H., Yoshimura, M
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo patch-clamp analysis of GABAB receptor-mediated inhibitory effects on noxious and innocuous mechanical synaptic transmission in' substantia gelatinosa neurons of the rat spinal cord. (2006)
  • 著者名/発表者名: Takeshima, K., Fume, H., Yoshimura, M
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Whole-cell patch-clamp analysis of firing patterns of ventral horn neurons in young adult rat in vitro. (2006)
  • 著者名/発表者名: Hisamitsu, R., Shimada, H., Uta, D., Take, S., Fume, H., Yoshimura, M
  • 学会等名: The 36th Annual Meeting of Society for Neuroscience
  • 発表場所: Atlanta, USA
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] In vivo patch-clamp analysis of effects of bacrofen on noxious and innocuous synaptic transmission in substantia gelatinosa neurons of the rat spinal cord. (2006)
  • 著者名/発表者名: Takeshima, K., Fume, H., Yoshimura, M
  • 学会等名: The 28th Annual Meeting of JASP
  • 発表場所: Kobe, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Physiological properties of substantia gelatinosa neurons in neonatal rats by in vivo patch-clamp analysis. (2006)
  • 著者名/発表者名: Kawamata, M., Sugino, S., Kiya, T., Fume, H., Yoshimura, M., Namiki, A
  • 学会等名: The 28th Annual Meeting of JASP
  • 発表場所: Kobe, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Actions of serotonin on nociceptive transmission in the substantia gelatinosa of the rat spinla cord. (2006)
  • 著者名/発表者名: Abe, K., Fume, H., Koga, K., Kato, G., Yasaka, T., Tamae, A., Katafuchi, T., Yoshimura, M
  • 学会等名: The 29th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Kyoto, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [学会発表] Actions of local anesthetics on primary afferent synaptic transmission to the substantia gelatinosa of the rat spinal cord. (2006)
  • 著者名/発表者名: Uta, D., Fume, H., Rashid, MH., Yoshimura, M
  • 学会等名: The 29th Annual Meeting of the Japan Neuroscience Society
  • 発表場所: Kyoto, Japan
  • 説明: 「研究成果報告書概要(欧文)」より
• [図書] Patch-Clamp analysis:advanced techniques (2007)
  • 著者名/発表者名: Furue H, et. al.
  • 総ページ数: 475
  • 出版者: Humana Press
  • 説明: 「研究成果報告書概要(和文)」より
• [図書] Patch-Clamp Analysis : advanced techniques, Second Edition. (2007)
  • 著者名/発表者名: Furue H. et al.
  • 出版者: Humana Press Inc. (in press)