部位特異的な上皮間葉系相互作用を通じた皮膚疾患病態解明及び再生医療に関する研究

• 研究課題/領域番号: 18689028
• 研究種目: 若手研究(A)
• 配分区分: 補助金
• 研究分野: 皮膚科学
• 研究機関: 名古屋市立大学 (2007-2008); 大阪大学 (2006)
• 研究代表者: 山口 裕史 名古屋市立大学, 大学院・医学研究科, 准教授 (00335340)
• 研究期間 (年度): 2006 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 23,660千円 (直接経費: 18,200千円、間接経費: 5,460千円); 2008年度: 3,380千円 (直接経費: 2,600千円、間接経費: 780千円); 2007年度: 9,750千円 (直接経費: 7,500千円、間接経費: 2,250千円); 2006年度: 10,530千円 (直接経費: 8,100千円、間接経費: 2,430千円)
• キーワード: 皮膚腫瘍学 / 創傷治癒学 / 再生医学 / 色素細胞学 / 皮膚発生学 / 線維芽細胞 / 表皮細胞 / メラノサイト / 再生医療 / 創傷治癒 / 皮膚癌 / 紫外線 / 悪性黒色腫 / 部位特異性 / 上皮間葉系相互作用

研究概要

「ヒト成人においても、上皮間葉系相互作用(真皮線維芽細胞がその上にある上皮系細胞に与える作用)により部位特異性(皮膚のさまざまな部位で性質が異なること)を決定付けていること」を実証してきた。手のひら・足のうらの皮膚は、分厚い皮膚で外からの刺激に強い・毛が無い・色素が薄いという3つの特徴がある。手のひら・足のうらの真皮線維芽細胞で発現が高いDKK1が、メラノサイトの機能を抑えるだけでなく、表皮細胞のメラニン取り込み能を抑制すると同時に、重層化を促進している結果を得ることが出来た。

研究成果

• [雑誌論文] Regulation of skin pigmentation and thickness by DKK1 (2009)
  • 著者名/発表者名: Yamaguchi Y(4名・筆頭・責任著者) Morita A, et al.
  • 雑誌名: J Investig DermatolSymp Proc (in press)
  • 査読あり
• [雑誌論文] Intractable wounds caused by pyoderma gangrenosum in a patient with critical limb ischemia treated with cyclosporine and adjuvant sympathectomy. (2009)
  • 著者名/発表者名: Takahashi Y, Yamaguchi Y(6名・共筆頭・責任著者), et al.
  • 雑誌名: Dermatol Surg (Epub)
  • 査読あり
• [雑誌論文] Short- and long-term effects of UV radiation on the skin. (2009)
  • 著者名/発表者名: Coelho SG, 中略, Yamaguchi Y(15名・5番目), et al.
  • 雑誌名: J Investig Dermatol Symp Proc (in press)
  • 査読あり
• [雑誌論文] Molecular basis of premature skin aging induced by tobacco smoking. (2009)
  • 著者名/発表者名: Morita A, 中略, Yamaguchi Y(4名・最終著者)
  • 雑誌名: J Investig Dermatol Symp Proc (in press)
  • 査読あり
• [雑誌論文] Stage III melanoma treated with chemotherapy after surgery during the second trimester of pregnancy. (2009)
  • 著者名/発表者名: Ishida I, Yamaguchi Y(7名・共筆頭・責任著者), T et al.
  • 雑誌名: ArchDermatol 145(3) ページ: 346-8
  • 査読あり
• [雑誌論文] The development of a filter to enhance the efficacy and safety of excimer light (308 nm) therapy. (2009)
  • 著者名/発表者名: Kobayashi K, 中略, Yamaguchi Y(11名・10番目), et al.
  • 雑誌名: Photodermatol Photoimmunol Photomed 25(1) ページ: 30-6
  • 査読あり
• [雑誌論文] Feasibility and a ccuracy of anewly developed hand-held device with a flat-type fluorescent lamp for measuring the minimal erythema dose for narrow-band UVB. (2009)
  • 著者名/発表者名: Morita A, 中略, Yamaguchi Y(8名・7番目), et al.
  • 雑誌名: Photodermatol Photoimmunol Photomed 25(1) ページ: 41-4
  • 査読あり
• [雑誌論文] Embryonic hair follicle fate change by augmented beta-catenin signaling through Shh and Bmp signaling. (2009)
  • 著者名/発表者名: Suzuki K, Yamaguchi Y(13名・2番目), et al.
  • 雑誌名: Development 136(3) ページ: 367-72
  • 査読あり
• [雑誌論文] Embryonic hair follicle fate change by augmented betacatenin signaling thro ugh Shh and Bmp signaling (2009)
  • 著者名/発表者名: Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Ts ukiyama T, Yamaguchi TP, Kato S, Birchmeier W, Yamada G
  • 雑誌名: Development 136(3) ページ: 367-372
  • 査読あり
• [雑誌論文] The development of a filter to enhance the efficacy and safety of excimer ight (308 nm) therapy (2009)
  • 著者名/発表者名: Kobayashi K, Yasuda Y, Shintani Y, Sumitomo T, Saga T, Kimura M, Yamamoto A, Mori T, Maeda A, Yamaguchi Y, Morita A
  • 雑誌名: Photodermatol Photoimmunol Photomed 25(1) ページ: 30-36
  • 査読あり
• [雑誌論文] Feasibility and accuracy of a newly developed hand-held device with a flat-t ype fluorescent lamp for measuring the minimal erythema dose for narrow-b and UVB therapy (2009)
  • 著者名/発表者名: Morita A, Shintani Y, Nishida E, Kato H, Yoshida H, Minamoto M, Yamaguchi Y, Maeda A
  • 雑誌名: Photodermatol Photoimmunol Photomed 25(1) ページ: 41-44
  • 査読あり
• [雑誌論文] Stage III melanoma treated with chemotherapy after surgery during the seco nd trimester of pregnancy (2009)
  • 著者名/発表者名: lshida I, Yamaguchi Y, Tanemura A, Hosokawa K, !tam' S, Morita A, Katayama I. (Co-first and Cor responding author)
  • 雑誌名: Arch Dermatol (IN PRESS)
  • 査読あり
• [雑誌論文] al limb ischemia treated with cyclosporine and adjuvant sympathectomy (2009)
  • 著者名/発表者名: K, Sano S, Morita Ad Katayama I. (Co-first and Corresponding aut hor)
  • 雑誌名: Dermatol Surg (IN PRESS)
  • 査読あり
• [雑誌論文] Short and long-term effects of ultraviolet radiation on the pigmentation of human skin (2009)
  • 著者名/発表者名: Coelho SG, Choi W, Brenner M, Miyamura Y, Yamaguchi Y, Wolber R, Smuda C, Batzer J, Kolbe L, Ito S, Wakamatsu K, Zmudzka B, Beer JZ, Miller SA, Hearing VJ
  • 雑誌名: J Investig Dermatol Symp Proc (IN PRESS)
  • 査読あり
• [雑誌論文] Molecular basis of premature skin aging induced by tobacco smoking (2009)
  • 著者名/発表者名: Morita A, Torii K, Maeda A, Yam aguchi Y
  • 雑誌名: J Investig Dermatol Symp Proc (IN PRESS)
  • 査読あり
• [雑誌論文] Regulation of skin pigmentation and thickness by dickkopf 1 (DKK1) (2009)
  • 著者名/発表者名: Yamaguchi Y, Morita A, Maeda A, Hearing VJ
  • 雑誌名: J Investig Dermatol Symp Proc (IN PRESS)
  • 査読あり
• [雑誌論文] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis : less painful and more rapid formation of blisters. (2008)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(14名・共筆頭・責任著者), et al.
  • 雑誌名: J Dermatol Sci 50(3) ページ: 243-7
  • NAID: 10024119244
  • 査読あり
• [雑誌論文] BeerJZ, Hearing VJ. Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer. (2008)
  • 著者名/発表者名: Yamaguchi Y(3名・筆頭・責任著者)
  • 雑誌名: Arch DermatolRes (300 Suppl 1)
  • 査読あり
• [雑誌論文] DKK1 regulates skin pigmentation and thickness by affecting Wnt/・-catenin signaling in keratinocytes. (2008)
  • 著者名/発表者名: Yamaguchi Y(11名・筆頭・責任著者),Passeron T, et al.
  • 雑誌名: FASEB J 22(4) ページ: 1009-20
  • 査読あり
• [雑誌論文] Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking. (2008)
  • 著者名/発表者名: Watabe H, 中略, Yamaguchi Y(10名・4番目), et al.
  • 雑誌名: J Invest Dermatol 128(1) ページ: 162-74
  • 査読あり
• [雑誌論文] Dynamics of pigmentation induction by repeated UV exposures: dose, dose interval and UV spectrum dependence. (2008)
  • 著者名/発表者名: Miller SA, 中略, Yamaguchi Y(7名・5番目), et al.
  • 雑誌名: Br J Dermatol 159 ページ: 921-30
  • 査読あり
• [雑誌論文] Congenital peristernal dermal sinuses: a new entity? (2008)
  • 著者名/発表者名: Kubo T, 中略, Yamaguchi Y(5名・3番目),et al.
  • 雑誌名: Br J Dermatol 159 ページ: 763-5
  • 査読あり
• [雑誌論文] Cyclobutane pyrimidine dimer formation and p53 production in human skin. (2008)
  • 著者名/発表者名: Yamaguchi Y(7名・筆頭著者), Coelho SG, et al.
  • 雑誌名: Exp Dermatol 17(11) ページ: 916-24
  • 査読あり
• [雑誌論文] Apocrine adenocarcinoma originating from the Moll's gland of the eyelid: report of a case. (2008)
  • 著者名/発表者名: Kanazawa S, 中略, Yamaguchi Y(7名・4番目), et al.
  • 雑誌名: Eur J Plast Surg 31 ページ: 333-6
  • 査読あり
• [雑誌論文] Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting W nt/betacatenin signaling in keratinocytes (2008)
  • 著者名/発表者名: Yamaguchi Y, Passeron T, Hoashi T, Watabe H, Rouzaud F, Yasum oto K, Hara T, Tohyama C, Katay ama I, Miki T, Hearing VJ. (Corr esponding author)
  • 雑誌名: FASEB J 22(4) ページ: 1009-1020
  • 査読あり
• [雑誌論文] Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiati on : factors influencing the incidence of skin cancer (2008)
  • 著者名/発表者名: Yamaguchi Y, Beer JZ, Hearing V J. (Corresponding author)
  • 雑誌名: Arch Dermatol Res 300(Supplem ent 1) ページ: 43-50
  • 査読あり
• [雑誌論文] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis : less painful and more rapid formation of blisters (2008)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y, Nakam ura M, Kojima R, Shima R, Furui Y, Watanabe S, Takeuchi A, Kan eko N, Shintani Y, Maeda A, Tani M, Morita A, Katayama I. (Co-fi rst and Corresponding author)
  • 雑誌名: J Dermatol Sci 50(3) ページ: 243-247
  • NAID: 10024119244
  • 査読あり
• [雑誌論文] Cyclobutane pyrimidine dimer formation and p53 production in human skin a fter repeated UV exposure (2008)
  • 著者名/発表者名: Yamaguchi Y, Coelho SG, Zmudz ka BZ, Takahashi K, Beer JZ, He aring VJ, Miller SA
  • 雑誌名: Exp Dermatol 17(11) ページ: 916-924
  • 査読あり
• [雑誌論文] Dynamics of pigmentation induction by repeated UV exposures : dose, dose interval and UV spectrum dependence (2008)
  • 著者名/発表者名: Miller SA, Coelho SG, Zmudzka B Z, Bushar HF, Yamaguchi Y, Hea ring VJ, Beer JZ
  • 雑誌名: Br J Dermatol 159(4) ページ: 921-930
  • 査読あり
• [雑誌論文] Congenital peristernal dermal sinuses : a new entity? (2008)
  • 著者名/発表者名: Kubo T, Takagi T, Yamaguchi Y, Yano K, Hosokawa K
  • 雑誌名: Br J Dermatol 159(3) ページ: 763-765
  • 査読あり
• [雑誌論文] Apocrine adenocarcinoma originating from the Moll's gland of the eyelid : report of a case (2008)
  • 著者名/発表者名: Kanazawa S, Kubo T, Tanag MA, Yamaguchi Y, Hoshida Y, Yano K, Hosokawa K
  • 雑誌名: Eur J Plast Surg 31(6) ページ: 333-336
  • 査読あり
• [雑誌論文] Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking.[Selected as Journal Cover] (2008)
  • 著者名/発表者名: Watabe H, Valencia J, Le Pape E, Yamaguchi Y, Nakamura M, Rouzaud F, Hoashi T, Kawa Y, Mizoguchi M, Hearing VJ.
  • 雑誌名: J Invest Dermatol 128(1) ページ: 162-174
  • 査読あり
• [雑誌論文] The effects of dickkopf 1 on keratinocyte gene profiles and on Wnt/-catenin signaling pathways:the mechanisms by which dickkopf 1 reduces cell/cell contact and melanosome transfer (2008)
  • 著者名/発表者名: Yamaguchi Y(Corresponding author), Passeron T, Watabe H, Hoashi T, Rouzaud F, Yasumoto K, Hara T, Mild T, Itami S, Katayama I, Hearing VJ.
  • 雑誌名: FASEB J 22(4) ページ: 1009-1020
  • 査読あり
• [雑誌論文] Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation:factors influencing the incidence of skin cancer (2008)
  • 著者名/発表者名: Yamaguchi Y(Corresponding author), Beer JZ, Hearing VJ.
  • 雑誌名: Arch Dermatol Res 300(Supplement 1) ページ: 43-50
  • 査読あり
• [雑誌論文] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis:less painful and more rapid formation of blisters (2008)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(Co-first and Corresponding author), Nakamura M, Kojima R, Shima R, Furui Y, Watanabe S, Takeuchi A, Kaneko N, Shintani Y, Maeda A, Tani M, Morita A, Katayama I.
  • 雑誌名: J Dermatol Sci 50(3) ページ: 243-247
  • 査読あり
• [雑誌論文] Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV exposure (2008)
  • 著者名/発表者名: Yamaguchi Y, Coelho SG, Zmudzka BZ, Takahashi K, Beer JZ, Hearing VJ, Miller SA.
  • 雑誌名: Exp Dermatol ページ: 23-23
  • 査読あり
• [雑誌論文] Dynamics of pigmentation induction by repeated UV exposures:dose,dose interval and UV spectrum dependence (2008)
  • 著者名/発表者名: Miller SA, Coelho SG, Zmudzka BZ, Bushar HF, Yamaguchi Y, Hearing VJ, Beer JZ.
  • 雑誌名: Br J Dermatol (In press)
  • 査読あり
• [雑誌論文] Congenital peristernal dermal sinuses:a new entity? (2008)
  • 著者名/発表者名: Kubo T, Takagi T, Yamaguchi Y, Yano K, Hosokawa K.
  • 雑誌名: Br J Dermatol (In press)
  • 査読あり
• [雑誌論文] Stage III melanoma treated with chemotherapy after surgery during the second trimester of pregnancy (2008)
  • 著者名/発表者名: Ishida I, Yamaguchi Y(Co-first and Corresponding author), Tanemura A, Hosokawa K, Itami S, Morita A, Katayama I.
  • 雑誌名: Arch Dermatol (In press)
  • 査読あり
• [雑誌論文] Wounds caused by pyoderma gangrenosum and vasculopathy secondary to diabetes mellitus treated with cyclosporine and sympathectomy (2008)
  • 著者名/発表者名: Takahashi Y, Yamaguchi Y(Co-first and Corresponding author), Itoh K, Sano S, Morita A, Katayama I.
  • 雑誌名: Dermatol Surg (In press)
  • 査読あり
• [雑誌論文] Epithelioid sarcoma on the foot masquerading as an intractable wound for 24 years (2008)
  • 著者名/発表者名: Nishimura Y, Yamaguchi Y(Corresponding author), Hamada K, Tomita Y, Morita A, Katayama I.
  • 雑誌名: Clin Exp Dermatol (In press)
  • 査読あり
• [雑誌論文] Embryonic hair follicle fate alteration by augmented beta-catenin signaling relayed by Bmp receptor(BmprIA) (2008)
  • 著者名/発表者名: Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Tsukiyama T, Yamaguchi TP, Kato S, Birchmeier W, Yamada G.
  • 雑誌名: Development (In press)
  • 査読あり
• [雑誌論文] Katayama I. Intractable wounds caused by arteriosclerosis obliterans with end-stage renal disease treated by aggressive debridement and epidermal grafting. (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(3名・責任著者),
  • 雑誌名: J Am Acad Dermatol 57(2) ページ: 322-6
  • 査読あり
• [雑誌論文] Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates. (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(6名・責任著者),et al.
  • 雑誌名: J Am Acad Dermatol 57(6) ページ: 1021-5
  • 査読あり
• [雑誌論文] IRegulation of human skin pigmentation and responses to UV radiation. (2007)
  • 著者名/発表者名: Miyamura Y, 中略, Yamaguchi Y(14名・12番目), et al.
  • 雑誌名: Pigment Cell Res 20(1) ページ: 2-13
  • 査読あり
• [雑誌論文] The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferation. (2007)
  • 著者名/発表者名: Yamaguchi Y(7名・筆頭・責任著者),Passeron T, et al.
  • 雑誌名: J Invest Dermatol 127(5) ページ: 1217-25
  • 査読あり
• [雑誌論文] Intractable wounds from a herpe ssimplex infection in an immunosuppressed patient with rheumatoid arthritis. (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(4名・責任著者), et al.
  • 雑誌名: Arch Dermatol 143(10) ページ: 1340-2
  • 査読あり
• [雑誌論文] Brenner M, Hearing VJ. The regulation of skin pigmentation. (2007)
  • 著者名/発表者名: Yamaguchi Y(3名・筆頭著者),
  • 雑誌名: J Biol Chem 282(38) ページ: 27557-61
  • 査読あり
• [雑誌論文] Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. (2007)
  • 著者名/発表者名: Valencia JC, Yamaguchi Y(14名・6番目), et al.
  • 雑誌名: J Biol Chem 282(15) ページ: 11266-80
  • 査読あり
• [雑誌論文] Regulation of human skin pigmentation and responses to ultraviolet rad iation (2007)
  • 著者名/発表者名: Miyamura Y, Coelho SG, Wolber R, Miller SA, Wakamatsu K, Z mudzka BZ, Ito S, Smuda C, Passeron T, Choi W, Batzer J, Yamaguchi Y, Beer JZ, Hearing VJ.
  • 雑誌名: Pigment Cell Res 20(1) ページ: 2-13
  • 査読あり
• [雑誌論文] Sialylated core 1 O-glycans influence the sorting of Pme117/gp100 and determine its capacity to form fibrils (2007)
  • 著者名/発表者名: Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Miller Jenkins LM, Nagashima K, Appella E, Hearing VJ.
  • 雑誌名: J Biol Chem 282(15) ページ: 11266-11280
  • 査読あり
• [雑誌論文] The effects of dickkopf 1(DKK1)on gene expression and Wnt signaling by melanocytes:mechanisms underlying its suppression of melanocyte function and proliferation (2007)
  • 著者名/発表者名: Yamaguchi Y(Corresponding author), Passeron T, Watabe H, Yasumoto K, Rouzaud F, Hoashi T, Hearing VJ.
  • 雑誌名: J Invest Dermatol 127(5) ページ: 1217-1225
  • 査読あり
• [雑誌論文] Intractable wounds caused by arteriosclerosis obliterans with end-stage renal disease treated by aggressive debridement and epidermal grafting (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y, Katayama I.
  • 雑誌名: J Am Acad Dermatol 57(2) ページ: 322-326
  • 査読あり
• [雑誌論文] The regulation of skin pigmentation.[Selected as Journal Cover] (2007)
  • 著者名/発表者名: Yamaguchi Y, Brenner M, Hearing VJ.
  • 雑誌名: J Biol Chem 282(38) ページ: 27557-27561
  • 査読あり
• [雑誌論文] Intractable wounds from a herpes simplex infection in an immunosuppressed patient with rheumatoid arthritis (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(Corresponding author), Kitaba S, Katayama I.
  • 雑誌名: Arch Dermatol 143(10) ページ: 1340-1342
  • 査読あり
• [雑誌論文] Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y(Corresponding author), Tani M, Umegaki N, Nishimura Y, Katayama I.
  • 雑誌名: J Am Acad Dermatol 57(6) ページ: 1021-1025
  • 査読あり
• [雑誌論文] The effects of dickkopf 1 (DKK1) on gene expression and Wnt signaling by melanocytes : mechanisms underlying its suppression of melanocyte function and proliferation. (2007)
  • 著者名/発表者名: Yamaguchi Y, Passeron T, Watabe H, Yasumoto K, Rouzaud F, Hoashi T, Hearing VJ
  • 雑誌名: Journal of Investigative Dermatology (J Invest Dermatol) 127(In press)
• [雑誌論文] Sialylated core 10-glycans influence the sorting of Pmel 17/gplOO and determine its capacity to form fibrils. (2007)
  • 著者名/発表者名: Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Miller Jenkins LM, Nagashima K, Appella E, Hearing VJ
  • 雑誌名: J Biol Chem (In Press)
• [雑誌論文] Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation : factors influencing the incidence of skin cancer. (2007)
  • 著者名/発表者名: Yamaguchi Y, Beer JZ, Hearing VJ
  • 雑誌名: J Deramtol Sci (In Press)
• [雑誌論文] Intractable wounds from a herpes simplex infection in an immunosuppressed patient with rheumatoid arthritis. (2007)
  • 著者名/発表者名: Hanafusa T, Yamaguchi Y (Corresponding author), Kitaba S, Katayama I
  • 雑誌名: Arch Deramtol (In press)
• [雑誌論文] 難治性趾端・指端潰瘍の治療法の展望 (2007)
  • 著者名/発表者名: 山口裕史
  • 雑誌名: 皮膚病診療 (In press)
• [雑誌論文] Regulation of human skin pigmentation and responses to ultraviolet radiation. (2007)
  • 著者名/発表者名: Miyamura Y, Coelho SG, Wolber R, Miller SA, Wakamatsu K, Zmudzka BZ, Ito S, Smuda C, Passeron T, Choi W, Batzer J, Yamaguchi Y, Beer JZ, Hearing VJ
  • 雑誌名: Pigment Cell Research 20(1) ページ: 2-13
• [雑誌論文] UV increases the nuclear localization of APE/Ref-1 in human skin. (2006)
  • 著者名/発表者名: Takahashi K, 中略, Yamaguchi Y(7名・3番目), et al.
  • 雑誌名: J Invest Dermatol 126(12) ページ: 2723-6
  • 査読あり
• [雑誌論文] Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. (2006)
  • 著者名/発表者名: Yamaguchi Y(9名・筆頭著者), TakahashiK, et al.
  • 雑誌名: FASEB J 20(9) ページ: 1486-8
  • 査読あり
• [雑誌論文] Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2 : evidence for the polarized nature of melanocytes. (2006)
  • 著者名/発表者名: Valencia JC, 中略, Yamaguchi Y(14名・8番目), et al.
  • 雑誌名: J Cell Sci 119(Pt 6) ページ: 1080-91
  • 査読あり
• [雑誌論文] Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG. (2006)
  • 著者名/発表者名: Watari A, 中略, Yamaguchi Y(14名・8番目), et al.
  • 雑誌名: Oncogene 25(56) ページ: 7373-80
  • 査読あり
• [雑誌論文] Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. (2006)
  • 著者名/発表者名: Rouzaud F, 中略, Yamaguchi Y(10名・3番目), et al.
  • 雑誌名: FASEB J 20(11) ページ: 1927-9
  • 査読あり
• [雑誌論文] Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1-receptor isoforms. (2006)
  • 著者名/発表者名: Rounzaud F, Costin EG, Yamaguchi Y, Valencia JC, Berens WF, Chen K, Hoashi T, Bohm M, Abdel-Malek Z, Hearing VJ
  • 雑誌名: FASEB Journal 20(11) ページ: 1927-1929
• [雑誌論文] Suppression of tumorigenicity, but not anchorage-independence, of human cancer cells by new candidate tumor suppressor gene CapG. (2006)
  • 著者名/発表者名: Watari A, Takaki K, Higashiyama S, Li Y, Satomi Y, Takao T, Tanemura A, Yamaguchi Y, Katayama I, Shimakage M, Miyashiro I, Takami K, Kodama K, Yutsudo M
  • 雑誌名: Oncogene 25(56) ページ: 7373-7380
• [雑誌論文] UV increases the nuclear localization of apurinic/apyrimidinic endonuclease (APE1/Ref-1) in human skin. (2006)
  • 著者名/発表者名: Takahashi K, Hoashi T, Yamaguchi Y, Mutsuga N, Suzuki I, Vieira WD, Hearing VJ
  • 雑誌名: J Invest Dermatol 126(12) ページ: 2723-2726
• [雑誌論文] Human skin responses to UV radiation : pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. (2006)
  • 著者名/発表者名: Yamaguchi Y, Takahashi K, Zmudzka BZ, Kornhauser A, Miller SA, Tadokoro T, Berens W, Beer JZ, Hearing VJ
  • 雑誌名: FASEB Journal 20(9) ページ: 1486-1488
• [雑誌論文] Sorting of Pmel 17 to melanosomes through the plasma membrane by API and AP2 : evidence for the polarized nature of melanocytes. (2006)
  • 著者名/発表者名: Valencia JC, Watabe H, Chi A, Rouzaud F, Chen KG, Vieira WD, Takahashi K, Yamaguchi Y, Berens W, Nagashima K, Shabanowitz J, Hunt DF, Appella E, Hearing VJ
  • 雑誌名: J Cell Sci 119 (6)
• [雑誌論文] 「最近のトピックス 2006 Clinical Dermatology 2006」皮膚疾患の病態 皮膚潰瘍の治癒機転における表皮真皮相互作用 (2006)
  • 著者名/発表者名: 山口裕史
  • 雑誌名: 臨床皮膚科 60(5) ページ: 37-43
• [雑誌論文] 海外研究施設・ラボ紹介「Laboratory of Cell Biology, National Cancer Institute,National Institutes of Health, Bethesda, Maryland, USAJ (2006)
  • 著者名/発表者名: 山口裕史
  • 雑誌名: 皮膚アレルギーフロンテイア 4(1) ページ: 44-45
• [雑誌論文] 「病態よりみた難治性下腿潰瘍の診断と治療」糖尿病性潰瘍の診断と治療 (2006)
  • 著者名/発表者名: 辻隆治, 山口裕史, 片山一朗, 矢野健二, 細川亙
  • 雑誌名: 形成外科 49(2) ページ: 159-169
• [雑誌論文] Epithelioid sarcoma on the foot masquerading as an intractable wound
  • 著者名/発表者名: Nishimura Y, Yamaguchi Y, Hama da K, Tomita Y, Maeda A, Morita A, Katayama I
  • 雑誌名: Clin Exp Dermatol (IN PRESS)
  • 査読あり
• [学会発表] Adult dermal fibroblasts determine the fate of the overlying epidermis. (2009)
  • 著者名/発表者名: Yamaguchi Y.
  • 学会等名: The Global COE Liaison Laboratory regular seminar
  • 発表場所: [Invited lecturer] Kumamoto, Japan.
  • 年月日: 2009-05-04
• [学会発表] Adult dermal fibroblasts determine the fate of the overlying epide rmis (2009)
  • 著者名/発表者名: Yamaquchi Y
  • 学会等名: The Global COE Liaison Laboratory regular seminar
  • 発表場所: Kumamoto, Japan
  • 年月日: 2009-03-04
• [学会発表] The effect of UV on human skin pigmentation. (2009)
  • 著者名/発表者名: Yamaguchi Y.
  • 学会等名: The 3rd Annual Symposium in Institute of Dermatological Science
  • 発表場所: [Invited lecturer] Seoul, Korea.
  • 年月日: 2009-02-06
• [学会発表] The effect of UV on human skin pigmentation (2009)
  • 著者名/発表者名: Yamaquchi Y
  • 学会等名: 3^<rd> Annual Symposium in Institute of Dermatological Science
  • 発表場所: Seoul, Korea
  • 年月日: 2009-02-06
• [学会発表] Melanocyte Biology (2009)
  • 著者名/発表者名: Yamaguchi Y .
  • 学会等名: Pre-seminar for the 3rd Annual Symposium in Institute of Dermatological Science
  • 発表場所: [Invited lecturer] Seoul, Korea.
  • 年月日: 2009-02-05
• [学会発表] Melanocyte biology (2009)
  • 著者名/発表者名: Yamaquchi Y
  • 学会等名: Preseminar for the 3^<rd> Annual Symposium in Institute of Dermatological Science
  • 発表場所: Seoul, Korea
  • 年月日: 2009-02-05
• [学会発表] The efficacy of epidermal grafting (2008)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: World Congress of Dermatology
  • 発表場所: Buenos Aires,Argentine
  • 年月日: 2008-10-03
• [学会発表] The effects of dickkopf 1 on skin pigmentation. (2008)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: Avon invited lecture series
  • 発表場所: New York,USA
  • 年月日: 2008-05-16
• [学会発表] Regulation of skin pigmentation and thickness by dickkopf 1(DKK1). (2008)
  • 著者名/発表者名: Yamaguchi Y.
  • 学会等名: IID 2008 Satellite Symposium Photoaging Research Symposium
  • 発表場所: Kyoto, Japan
  • 年月日: 2008-05-13
• [学会発表] Regulation of skin pigmentation and thickness by dickkopf 1 (DKK 1) (2008)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: IID 2008 Satellite Symposium Photoaging Research Symposium
  • 発表場所: Kyoto, Japan
  • 年月日: 2008-05-13
• [学会発表] The effects of dickkopf 1 on gene expression and Wnt signaling by kera tirtocvtes. (2008)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: Society for Investigative dermatology
  • 発表場所: Los Angeles,USA
  • 年月日: 2008-05-11
• [学会発表] Workshop : CS-14 Molecular and surgical pathology. (2008)
  • 著者名/発表者名: Yamaguchi Y.
  • 学会等名: The 20th International Pigment Cell Conference and 5th International Melanoma Research Conference.
  • 発表場所: Sapporo, Japan
• [学会発表] CS-14 Molecular and surgical pathology (2008)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: The 20th International Pigment Cell Conference and 5th International Melanoma Research Conference
  • 発表場所: Sapporo, Japan
• [学会発表] Suction blister formation time reduction by subepidermal injection (2008)
  • 著者名/発表者名: Yamaquchi Y, Hanafusa T, Nakamura M, Morita A
  • 学会等名: IID 2008 (International Investigative Dermatology 200 81
  • 発表場所: Kyoto, Japan
• [学会発表] The effect of DKK1 on human skin (2007)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: Korean Society for Investigative Dermatology
  • 発表場所: Seoul,Korea
  • 年月日: 2007-10-17
• [学会発表] Regulation of skin pigmentation. (2007)
  • 著者名/発表者名: Yamaguchi Y .
  • 学会等名: Avon Lecture Series for Pigment Cell Research.
  • 発表場所: New York, NY, USA
  • 年月日: 2007-05-15
• [学会発表] The effect of DKK1 on keratinocytes (2007)
  • 著者名/発表者名: Yamaguchi Y
  • 学会等名: Japanese Society for Investigative Dermatology
  • 発表場所: Yokohama,Japan
  • 年月日: 2007-04-20
• [学会発表] Epidermal sheet grafting for chronic wound.Workshop : Modern wound management. (2007)
  • 著者名/発表者名: Yamaguchi Y.
  • 学会等名: The 21st World Congress of Dermatology.
  • 発表場所: Buenos Aires, Argentina
• [学会発表] The effects of dickkopf 1 on gene expression and Wnt signaling by keratinocytes: mechanisms regulating skin pigmentation and thickness. (2007)
  • 著者名/発表者名: Yamaguchi Y, Passeron T, Katayama I, Hearing VJ.
  • 学会等名: The 68th Annual Meeting of the Society for Investigative Dermatology.
  • 発表場所: LosAngeles, CA, USA
• [図書] 看護学テキストNiCE疾患論第17章皮膚疾患色素異常症 (2009)
  • 著者名/発表者名: 山口裕史
  • 総ページ数: 500
  • 出版者: 南光堂(Inpress)
• [図書] 1冊でわかる光皮膚科-皮膚科医に必須のPhotodermatology紫外線とメラノサイト (2009)
  • 著者名/発表者名: 山口裕史
  • 総ページ数: 232
  • 出版者: 文光堂
• [図書] 1冊でわかる光皮膚科 (2008)
  • 著者名/発表者名: 山口 裕史
  • 総ページ数: 232
  • 出版者: 分光堂
• [図書] すぐに役立つ日常皮膚診療における私の工夫 G.ありふれた皮膚疾患のベスト治療と私の工夫 13.尋常性白斑 (2007)
  • 著者名/発表者名: 山口 裕史、片山 一朗
  • 総ページ数: 309
  • 出版者: 全日本病院出版会
• [図書] 皮膚科診療プラクティス 20巻 1.光皮膚科学 1)急性皮膚障害 (2007)
  • 著者名/発表者名: 山口 裕史、森田 明理
  • 総ページ数: 365
  • 出版者: メディカルリビュー社
• [図書] 皮膚科診療プラクティス 20巻 1.光皮膚科学 1) 急性皮膚障害. (2007)
  • 著者名/発表者名: 山口裕史, 森田明理
  • 出版者: メディカルリビュー社(In press)
• [図書] すぐに役立つ日常皮膚診療における私の工夫 G. ありふれた皮膚疾患のベスト治療と私の工夫 13.尋常性白斑 (2007)
  • 著者名/発表者名: 山口裕史, 片山一朗
  • 総ページ数: 6
  • 出版者: 全日本病院出版会
• [図書] Melanocyte distribution and function in human skin (2006)
  • 著者名/発表者名: Yamaguchi Y(2名・筆頭著者)
  • 出版者: Humana Press
• [図書] Chapter 6 : Melanocyte distribution and function in human skin. From Melanocytes to Malignant Melanoma (2006)
  • 著者名/発表者名: Yamaguchi Y, Hearing VJ
  • 総ページ数: 15
  • 出版者: Humana Press
• [図書] 細胞増殖因子と再生医療 HGF 皮膚潰瘍 (2006)
  • 著者名/発表者名: 山口裕史, 板見智
  • 総ページ数: 5
  • 出版者: メディカルリビュー社
• [図書] 皮膚のガン 予防とっきあい方シリーズ 老年病・認知症 (2006)
  • 著者名/発表者名: 山口裕史
  • 総ページ数: 164
  • 出版者: メディカルリビュー社
• [備考]
  • URL: http://read.jst.go.jp/