サル側頭葉36野からTE野へ逆行性に伝達する記憶情報のスパイク-フィールド相関

• 研究課題/領域番号: 18700309
• 研究種目: 若手研究(B)
• 配分区分: 補助金
• 研究分野: 神経科学一般
• 研究機関: 東京大学
• 研究代表者: 竹田 真己 東京大学, 大学院・医学系研究科, 助教 (00418659)
• 研究期間 (年度): 2006 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 3,710千円 (直接経費: 3,500千円、間接経費: 210千円); 2008年度: 910千円 (直接経費: 700千円、間接経費: 210千円); 2007年度: 900千円 (直接経費: 900千円); 2006年度: 1,900千円 (直接経費: 1,900千円)
• キーワード: 認知神経科学 / 脳・神経 / 大脳生理学 / 視覚記憶 / 神経科学 / 視覚状態

研究概要

視覚記憶課題遂行中のサル下部側頭葉における単一ユニット活動と局所フィールド電位を記録し、周波数領域の相関解析を行ったところ、これらの神経活動がコヒーレントに活動していた。課題関連部位をin vivoで同定するために、高磁場MRIを用いた記録部位同定法を開発した。電極ファントムを作成し高精度に記録部位を同定する撮像条件を調べた。この条件下でサル大脳皮質内の記録部位を同定すると、1ボクセル以下の誤差で同定できた。

研究成果

• [雑誌論文] Functional characterization of area 35 in the macaque perirhinal cortex during a pair association task. Program No. 219.1. (2008)
  • 著者名/発表者名: Fujimichi, R., Takeda, M., Naya, Y., Koyano, K.W., Takeuchi, D., Miyashita, Y.
  • 雑誌名: 2008 Neuroscience Meeting Planner Washington, DC: Society for Neuroscience
  • 査読あり
• [雑誌論文] Electrolysis of an elgiloy electrode can create MRI-visible metal deposit marks at recording sites. Program No. 885.2. (2008)
  • 著者名/発表者名: Koyano, K.W., Machino., A, Takeda, M., Fujimichi, R., Ohashi, Y., Matsui, T., Miyashita, Y.
  • 雑誌名: 2008 Neuroscience Meeting Planner Washington, DC: Society for Neuroscience
  • 査読あり
• [雑誌論文] Neuronal activities in area 35 of macaque perirhinal cortex during a pair association task (2008)
  • 著者名/発表者名: Fujimichi, R., Takeda, M., Naya, Y., Koyano K.W., Takeuchi, D., Miyashita, Y.
  • 雑誌名: Neuroscience Research 61(Suppl.1)
  • 査読あり
• [雑誌論文] MRI-based in vivo detection of recording sites marked by electrolysis of an elgiloy electrode (2008)
  • 著者名/発表者名: Koyano, K.W., Takeda, M., Fujimichi, R., Ohashi, Y., Miyashita, Y.
  • 雑誌名: Neuroscience Research 61(Suppl.1)
  • 査読あり
• [雑誌論文] Functional characterization of area 35 in the macaque perirhinal cortex during a nair association task (2008)
  • 著者名/発表者名: Fujimichi, R, Takeda, M, Naya, Y, Koyano, KW, Takeuchi, D, Miyashita, Y.
  • 雑誌名: 2008 Neuroscience Meeting Planner
• [雑誌論文] Electrolysis of an elgiloy electrode can create MRI-visible metal deposit marks at recording sites (2008)
  • 著者名/発表者名: Koyano, KW, Machino, A, Takeda, M, Fujimichi, R, Ohashi, Y, Matsui, T, Miyashita, Y.
  • 雑誌名: 2008 Neuroscience Meeting Planner
• [雑誌論文] Neuronal activities in area 35 of macaque perirhinal cortex during a pair association task (2008)
  • 著者名/発表者名: Fujimichi, R, Takeda, M, Naya, Y, Koyano KW, Takeuchi, D, Miyashita, Y.
  • 雑誌名: Neuroscience Research 61 (Supp1.1)
• [雑誌論文] MRI-based in vivo detection of recording sites marked by electrolysis of an elgiloy electrode. (2008)
  • 著者名/発表者名: Koyano, KW, Takeda, M, Fujimichi, R, Ohashi Y, Miyashita, Y.
  • 雑誌名: Neuroscience Research 61 (Supp1.1)
• [雑誌論文] MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy (2007)
  • 著者名/発表者名: Matsui, T., Koyano, K.W., Koyama, M., Nakahara, K., Takeda, T., Ohashi, Y., Naya, Y., Miyashita, Y.
  • 雑誌名: Nature methods 4 ページ: 161-168
  • 査読あり
• [雑誌論文] A non-magnetic mini-manipulaor for an MRI-based method for localization of a microelectrode tip within monkey cerebral cortex (2007)
  • 著者名/発表者名: Koyano, K.W., Ohashi, Y., Matsui, T., Takeda, M., Nakahara, K., Naya, Y., Koyama, M., Watanabe, T., Miyashita, Y.
  • 雑誌名: The Journal of Physiological Sciences 57(Suppl.)
  • 査読あり
• [雑誌論文] Anon-magnetic mini-manipulator for an MRI-based method for localization of a microelectrode tip within monkey cerebral cortex. (2007)
  • 著者名/発表者名: Koyano KW, Ohashi Y, Matsui T, Takeda M, Nakahara K, Naya Y, Koyama M, Watanabe T, Miyashita Y.
  • 雑誌名: The Journal of Physiological Sciences 4 ページ: 71-71
• [雑誌論文] Localization accuracy of microelectrode tip within the monkey temporal cortex using high-resolution MRI. Program No. 694.13. (2006)
  • 著者名/発表者名: Koyano, K.W., Matsui, T., Naya, Y., Koyama, M., Takeda, M., Nakahara, K., Miyashita, Y.
  • 雑誌名: 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience
  • 査読あり
• [雑誌論文] Localization of a microelectrode tip within the monkey temporal cortex (2006)
  • 著者名/発表者名: Koyano, K.W., Matsui, T., Naya, Y., Koyama, M., Takeda, M., Nakahara, K., Miyashita, Y.
  • 雑誌名: Neuroscience Research 55(Suppl. 1)
  • 査読あり
• [雑誌論文] Localization accuracy of microelectrode tip within the monkey temporal cortex using high-resolution MRI (2006)
  • 著者名/発表者名: Koyano, K.W., Matsui, T., Naya, Y., Koyama, M., Takeda, M., Nakahara, K., Miyashita Y.
  • 雑誌名: 2006 Neuroscience Meeting Planner
• [雑誌論文] Localization of a microelectrode tip within the monkey temporal cortex (2006)
  • 著者名/発表者名: Koyano, K.W., Matsui, T., Naya, Y., Koyama, M., Takeda, M., Nakahara, K., Miyashita, Y.
  • 雑誌名: Neuroscience Research 55(Suppl.1)
• [学会発表] MRI-detectable elgiloy deposit markers for in vivo recording site localization: deposit condition, scan parameters and long-term durability (2009)
  • 著者名/発表者名: Koyano, K.W., Machino, A., Takeda, M., Matsui, T., Fujimichi, R., Ohashi, Y., Miyashita, Y.
  • 学会等名: Second global COE retreat of "Integrative life science based on the study of biosignaling mechanisms"
  • 発表場所: Yamanashi, Japan
  • 年月日: 2009-03-07
• [学会発表] Neuronal representation of associative memory in macaque area 35 (perirhinal cortex) (2009)
  • 著者名/発表者名: Fujimichi, R., Takeda, M., Koyano, K.W., Takeuchi, D., Miyashita, Y.
  • 学会等名: Second global COE retreat of "Integrative life science based on the study of biosignaling mechanisms"
  • 発表場所: Yamanashi, Japan
  • 年月日: 2009-03-07
• [学会発表] Neuronal activity coding visual stimulus-stimulus associations in the monkey rhinal cortex (2008)
  • 著者名/発表者名: Fujimichi, R., Takeda, M., Naya, Y., Koyano, K.W., Takeuchi, D., Miyashita, Y.
  • 学会等名: First global COE retreat of "Integrative life science based on the study of biosignaling mechanisms"
  • 発表場所: Chiba, Japan
  • 年月日: 2008-03-08
• [学会発表] From where do we record?: MRI-based in vivo localization methods for microelectrode recordings from the monkey brain (2008)
  • 著者名/発表者名: Koyano, K.W., Takeda, M., Ohashi, Y., Fujimichi, R., Matsui, T., Naya, Y., Koyama, M., Nakahara, K., Miyashita, Y.
  • 学会等名: First global COE retreat of "Integrative life science based on the study of biosignaling mechanisms"
  • 発表場所: Chiba, Japan
  • 年月日: 2008-03-08
• [学会発表] Neuronal activity coding visual stimulus-stimulus associations in the monkey rhinal cortex. (2008)
  • 著者名/発表者名: Fujimichi R, Takeda M, Naya Y, Koyano KW, Takeuchi D, Miyashita Y.
  • 学会等名: First global COE retreat of "Integrative life science based on the study of biosignaling mechanisms"
  • 発表場所: Chiba, Japan
  • 年月日: 2008-03-08
• [学会発表] From where do we record?: MRI-based in vivo localization methods for microelectrode recordings from the monkey brain. (2008)
  • 著者名/発表者名: Koyano KW, Takeda M, Ohashi Y, Fujimichi R, Matsui T, Naya Y, Koyama M, Nakahara K, Miyashita Y.
  • 学会等名: First global COE retreat of "Integrative life science based on the study of biosignaling mechanisms"
  • 発表場所: Chiba, Japan
  • 年月日: 2008-03-08
• [学会発表] In vivo localization of electrophysiological recording sites within the monkey cortex using high-resolution MRI (2007)
  • 著者名/発表者名: Koyano, K.W., Matsui, T., Koyama, M., Naya, Y., Ohashi, Y., Takeda, M., Nakahara, K., Miyashita, Y.
  • 学会等名: University of California San Francisco Neuroscience Retreat
  • 発表場所: California, USA
  • 年月日: 2007-09-24
• [学会発表] In vivo localization of electrophysiological recording sites within the monkey cortex using high-resolution MRI. (2007)
  • 著者名/発表者名: Koyano KW, Matsui T, Koyama M, Naya Y, Ohashi Y, Takeda M, Nakahara K, Miyashita Y.
  • 学会等名: University of California San Francisco Neuroscience Retreat
  • 発表場所: California, USA
  • 年月日: 2007-09-24