脊椎動物頭部進化の比較分子発生学的解析

• 研究課題/領域番号: 18GS0320
• 研究種目: 学術創成研究費
• 配分区分: 補助金
• 研究機関: 独立行政法人理化学研究所
• 研究代表者: 相沢 慎一 独立行政法人理化学研究所, ボディプラン研究グループ, グループディレクター (60073011)
• 研究分担者: 嶋村 健児 熊本大学, 発生医学研究所, 教授 (70301140) ; 平田 たつみ 国立遺伝学研究所, 総合遺伝研究系, 准教授 (80260587)
• 研究期間 (年度): 2006 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 394,160千円 (直接経費: 303,200千円、間接経費: 90,960千円); 2010年度: 74,360千円 (直接経費: 57,200千円、間接経費: 17,160千円); 2009年度: 74,360千円 (直接経費: 57,200千円、間接経費: 17,160千円); 2008年度: 74,360千円 (直接経費: 57,200千円、間接経費: 17,160千円); 2007年度: 74,360千円 (直接経費: 57,200千円、間接経費: 17,160千円); 2006年度: 96,720千円 (直接経費: 74,400千円、間接経費: 22,320千円)
• キーワード: 脊椎動物系統発生 / 前後軸形成 / オーガナイザー / 頭部誘導 / 脳形成 / 皮質形成 / 比較発生学 / 比較ゲノム解析 / 脊椎動物 / 頭部形成 / 進化 / Otx / microRNA-9 / 頭部ギャップ遺伝子 / エンハンサー / 系統発生 / 胚体外組織 / 脳領域化 / Emx / ヘッドオーガナイザー / 胚体外内胚葉 / EPB41L5 / miR9 / 脊椎動物進化 / 吻側神経外胚葉 / microRNA / Foxg1 / Cajal-Retzius細胞 / 上皮間充織転換 / EPB4.1L5 / Pax6 / 四足動物 / 真骨魚 / ポリプテルス / エイ

研究概要

哺乳類(マウス、ウサギ、ブタ、スンクス)、爬虫類(ゲッコー、スッポン)、鳥類(ニワトリ)、両棲類(カエル)、総鰭類(シーラカンス)、腕鰭類(ポリプテルス)、真骨魚類(ゼブラフィッシュ、メダカ、フグ)、軟骨魚類(エイ)、無顎類(ヤツメウナギ)を比較発生及び比較ゲノム解析することによって、胚体外ヘッドオーガナイザー組織の相同的起源、ヘッドオーガナイザーOtx2遺伝子カスケードの肉鰭類での成立、条鰭類と肉鰭類で異なる神経外胚葉形成機構、皮質層構造形成の起源などを明らかにした。

研究成果

• [雑誌論文] MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. (2011)
  • 著者名/発表者名: Shibata M., Nakao H., Kiyonari H., Abe T., Aizawa S.
  • 雑誌名: J Neurosci. 31 ページ: 3407-3422
  • 査読あり
• [雑誌論文] Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging. (2011)
  • 著者名/発表者名: Abe T, Kiyonari H, Shioi G, Inoue KI, Nakao K, Aizawa, S, Fujimori T
  • 雑誌名: Genesis. (In print)
  • 査読あり
• [雑誌論文] A mouse reporter line toconditionally mark nuclei and cell membranes for in vivo live-imaging. (2011)
  • 著者名/発表者名: Shioi G, Kiyonari H, Abe T, Nakao K, Fujimori T, Jang CW, Huang CC, Akiyama H, Behringer RR, Aizawa, S
  • 雑誌名: Genesis. (In print)
  • 査読あり
• [雑誌論文] Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm. (2010)
  • 著者名/発表者名: Kurokawa D., Ohmura T., Ogino H., Takeuchi M., Inoue A., Inoue F., Suda Y., Aizawa S.
  • 雑誌名: Dev.Biol. 342 ページ: 110-120
  • 査読あり
• [雑誌論文] Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability. (2010)
  • 著者名/発表者名: Kiyonari H., Kaneko M., Abe S., Aizawa S.
  • 雑誌名: Genesis 48 ページ: 317-327
  • 査読あり
• [雑誌論文] The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone. (2010)
  • 著者名/発表者名: Suda Y., Kokura K., Kimura J., Kajikawa E., Inoue F., Aizawa S.
  • 雑誌名: Development 137 ページ: 2939-2949
  • 査読あり
• [雑誌論文] Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. (2010)
  • 著者名/発表者名: Sakurai Y., Kurokawa D., Kiyonari H., Kajikawa E., Suda Y., Aizawa S.
  • 雑誌名: Dev.Biol. 347 ページ: 392-403
  • 査読あり
• [雑誌論文] Proteomics Analysis of the Temporal Changes in Axonal Proteins during Maturation. (2010)
  • 著者名/発表者名: Yamatani H., Kawasaki T., Mita., S., Inagaki N., Hirata T.
  • 雑誌名: Dev.Neurobiol. 70 ページ: 523-537
  • 査読あり
• [雑誌論文] Evolution of Otx paralogue usages in early patterning of the vertebrate head. (2009)
  • 著者名/発表者名: Suda Y., Kurokawa D., Takeuchi M., Kajikawa E., Kuratani S., Amemiya C., Aizawa S.
  • 雑誌名: Developmental Biology 325 ページ: 282-295
  • 査読あり
• [雑誌論文] Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. (2009)
  • 著者名/発表者名: Matsuyama M., Aizawa S., Shimono A.
  • 雑誌名: PLos Genet. 5
  • 査読あり
• [雑誌論文] Germ layer patterning in bichir and lamprey ; an insight into its evolution in vertebrates. (2009)
  • 著者名/発表者名: Takeuchi M., Takahashi M., Okabe M., Aizawa S.
  • 雑誌名: Developmental Biology 332 ページ: 90-102
  • 査読あり
• [雑誌論文] Evolution of Otx paralogue usages in early patterning of the vertebrate head (2009)
  • 著者名/発表者名: Suda, Y., et al.
  • 雑誌名: Developmental Biology 325 ページ: 282-295
  • 査読あり
• [雑誌論文] Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium (2009)
  • 著者名/発表者名: Matsuyama, M., et al.
  • 雑誌名: PLos Genet. 5
  • 査読あり
• [雑誌論文] Germ layer patterning in bichir and lamprey ; an insight into its evolution in vertebrates (2009)
  • 著者名/発表者名: Takeuchi, M., et al.
  • 雑誌名: Developmental Biology 332 ページ: 90-102
  • 査読あり
• [雑誌論文] Role of the liver in glucose homeostatis in PI 3-kimase p85α-deficient mice (2009)
  • 著者名/発表者名: Aoki, K., et al.
  • 雑誌名: Am J.Physiol Emdocrinol Metab 296
  • 査読あり
• [雑誌論文] The formation of argpyrimidine, a methylglyoxal-arginine adduct, in the nucleus of neural cells (2009)
  • 著者名/発表者名: Nakadate, et al.
  • 雑誌名: Biochem.Biophys.Res.Comm. 378 ページ: 209-212
  • 査読あり
• [雑誌論文] The Genus Polypterus(Bichirs); A fish group diverged at the stem of Ray-finned fishes(Actinopterygii) (2009)
  • 著者名/発表者名: Takeuchi, M., et al.
  • 雑誌名: In Emerging Model Organisms(Cold Spring Harbor Laboratory Press) ページ: 447-468
• [雑誌論文] Evolution of Otx paralogue usages in early patterning of the vertebrate head (2009)
  • 著者名/発表者名: Suda, Y., Kurokawa, D., Takeuchi, M.,Kajikawa, E., Kuratani, S., Amemiya, C.and Aizawa, S
  • 雑誌名: Developmental Biology 325 ページ: 282-295
  • 査読あり
• [雑誌論文] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. (2008)
  • 著者名/発表者名: Hirano M., Hashimoto S., Yonemura S., Sabe H., Aizawa S.
  • 雑誌名: Journal of Cell Biology 182 ページ: 1217-1230
  • 査読あり
• [雑誌論文] MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. (2008)
  • 著者名/発表者名: Shibata M., Kurokawa D., Nakao H., Ohmura T., Aizawa S.
  • 雑誌名: J Neurosci. 28 ページ: 10415-21
  • 査読あり
• [雑誌論文] Retrospective on reverse genetics in mice around the wourld and in Japan. (2008)
  • 著者名/発表者名: Aizawa S.
  • 雑誌名: Develop.Growth Differ. 50
  • 査読あり
• [雑誌論文] Experience-Dependent Transfer of Otx2 Homeoprotein into the visual Cortex Activates Postnatal Plasticity. (2008)
  • 著者名/発表者名: Sugiyama S., Nardo AD., Aizawa S., Matsuo I., Volovitch M., Prochiantz A., Hensch TK.
  • 雑誌名: Cell 134 ページ: 208-520
  • 査読あり
• [雑誌論文] Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface. (2008)
  • 著者名/発表者名: Ito K., Kawasaki T., Takashima S., Matsuda I., Aiba A., Hirata T.
  • 雑誌名: J.Neurosci. 28 ページ: 4414-4422
  • 査読あり
• [雑誌論文] Method for electroporation for the early chick embryo. (2008)
  • 著者名/発表者名: Hatakeyama J., Shimamura K.
  • 雑誌名: Develop.Growth Differ. 50 ページ: 449-452
  • NAID: 10021097131
  • 査読あり
• [雑誌論文] Experience-Dependent Transfer of Otx2 Homeoproteininto the visual Cortex Activates PostnatalPlasticity (2008)
  • 著者名/発表者名: Sugiyama, S., Nardo, AD., Aizawa, S.,Matsuo, I., Volovitch, M., Prochiantz, A. and Hensch, TK
  • 雑誌名: Cell 134 ページ: 208-520
  • 査読あり
• [雑誌論文] EPB41L5functions to post-transcriptionallyregulate cadherin and integrin duringepithelial- mesenchymal transition (2008)
  • 著者名/発表者名: Hirano, M., Hashimoto, S., Yonemura, S.,Sabe, H. and Aizawa, S
  • 雑誌名: Journal of Cell Biology 182 ページ: 1217-1230
  • 査読あり
• [雑誌論文] differentiation by suppressing Foxg1 expression in mousemedial pallium (2008)
  • 著者名/発表者名: Shibata, M., Kurokawa, D., Nakao, H.,Ohmura, T. and Aizawa, S
  • 雑誌名: J Neurosci 28 ページ: 10415-21
  • 査読あり
• [雑誌論文] Semaphorin 3F confines ventral tangential migration oflateral olfactory tract neurons onto the telencephalonsurface (2008)
  • 著者名/発表者名: K Ito, T Kawasaki, S Takashima, I Matsuda, A Aiba, and T Hirata
  • 雑誌名: J. Neurosci 28 ページ: 4414-4422
  • 査読あり
• [雑誌論文] Establishment of framework of the cortical area is influenced by Otx1 (2008)
  • 著者名/発表者名: Ando, K.
  • 雑誌名: Neuroscience Research 60 ページ: 457-459
  • 査読あり
• [雑誌論文] Sfrp1, Sfrp2, and Sfrp5 Regulate the Wnt/β-Catenin and the Planar Cell Polarity Pathways During Early Trunk Formation in Mouse (2008)
  • 著者名/発表者名: Satoh, W.
  • 雑誌名: Genesis 46 ページ: 92-103
  • 査読あり
• [雑誌論文] Experience-Dependent Transfer of Otx2 Homeoprotein into the visual Cortex Activates Postnatal Plasticity (2008)
  • 著者名/発表者名: Sugiyama, S.
  • 雑誌名: Cell 134 ページ: 208-520
  • 査読あり
• [雑誌論文] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition (2008)
  • 著者名/発表者名: Hirano, M.
  • 雑誌名: Journal of Cell Biology 182 ページ: 1217-1230
  • 査読あり
• [雑誌論文] MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium (2008)
  • 著者名/発表者名: Shibata, M.
  • 雑誌名: Journal of Neuroscience 28 ページ: 10415-10421
  • 査読あり
• [雑誌論文] Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technology (2008)
  • 著者名/発表者名: Oginuma, M.
  • 雑誌名: Mech. Dev. 125 ページ: 432-440
  • 査読あり
• [雑誌論文] Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface (2008)
  • 著者名/発表者名: Ito, K.
  • 雑誌名: J. Neurosci. 28 ページ: 4414-4422
  • 査読あり
• [雑誌論文] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation (2008)
  • 著者名/発表者名: Takagi, K.
  • 雑誌名: Neuroscience 153 ページ: 1278-1288
  • 査読あり
• [雑誌論文] Method for electroporation for the early chick embryo. Develop. (2008)
  • 著者名/発表者名: Hatakeyama, J.
  • 雑誌名: Growth Differ. 50 ページ: 449-452
  • 査読あり
• [雑誌論文] Identification of presomitic mesoderm (PSM)-specific Mespl enhancer and generation of a PSM-specific Mespl/Mesp2-null mouse using. (2008)
  • 著者名/発表者名: Oginuma, M., et. al.
  • 雑誌名: Mech. Dev. ページ: 432-440
  • 査読あり
• [雑誌論文] Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis-sites 90kb apart. (2007)
  • 著者名/発表者名: Takasaki N., Kurokawa D., Nakayama R., Nakayama J., Aizawa, S.
  • 雑誌名: The EMBO Journal 26 ページ: 1649-1659
  • 査読あり
• [雑誌論文] Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. (2007)
  • 著者名/発表者名: Kimura-Yoshida C., Tian E., Nakano H., Amazaki S., Shimokawa K., Rossant J., Aizawa S., Matsuo I.
  • 雑誌名: PNAS 104 ページ: 5919-5924
  • 査読あり
• [雑誌論文] Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (2007)
  • 著者名/発表者名: Furushima K., Yamamoto A., Nagano T., Shibata M., Miyachi H., Abe T., Ohshima N., Kiyonari H., Aizawa S.
  • 雑誌名: Developmental Biology 306 ページ: 480-492
  • 査読あり
• [雑誌論文] Acetylated YY1 regulates Otx2 expressioninanterior neuroectoderm attwo cis-sites 90kbapart (2007)
  • 著者名/発表者名: Takasaki, N., Kurokawa, D., Nakayama, R., Nakayama, J. and Aizawa, S
  • 雑誌名: The EMBO Journal 26 ページ: 1649-1659
  • 査読あり
• [雑誌論文] Mouse homologues of Shisa antagonistic to Wnt and Fgfsignalings (2007)
  • 著者名/発表者名: Furushima, K., Yamamoto, A., Nagano,T., Shibata, M., Miyachi, H. and Abe, T., Ohshima, N., Kiyonari, H., Aizawa, S
  • 雑誌名: Developmental Biology 306 ページ: 480-492
  • 査読あり
• [雑誌論文] Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis-sites 90kb apart. (2007)
  • 著者名/発表者名: Takasaki, N., et. al.
  • 雑誌名: The EMBO Journal 26 ページ: 1649-1659
  • 査読あり
• [雑誌論文] Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. (2007)
  • 著者名/発表者名: Kimura-Yoshida, C., et. al.
  • 雑誌名: PNAS 104 ページ: 5919-5924
  • 査読あり
• [雑誌論文] Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (2007)
  • 著者名/発表者名: Furushima, K., et. al.
  • 雑誌名: Developmental Biology 306 ページ: 480-492
  • 査読あり
• [雑誌論文] Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. (2007)
  • 著者名/発表者名: Terauchi, Y., et. al.
  • 雑誌名: The Journal of Clinical Investigation 117 ページ: 246-257
  • 査読あり
• [雑誌論文] A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. (2007)
  • 著者名/発表者名: Remedios, R., et. al.
  • 雑誌名: Nature neuroscience 10 ページ: 1141-1150
  • 査読あり
• [雑誌論文] Angiomotin regulates endothelial cell migration during embryonic angioge nesis. (2007)
  • 著者名/発表者名: Aase, K., et. al.
  • 雑誌名: Genes & Development 21 ページ: 2055-2068
  • 査読あり
• [雑誌論文] Dkk3-Cre BAC Transgenic Mouse Line: A Tool for Highly Efficient Gene Deletion in Retinal Progenitor Cells. (2007)
  • 著者名/発表者名: Sato, S., et. al.
  • 雑誌名: Genesis 45 ページ: 502-507
  • 査読あり
• [雑誌論文] Contrasting and brain region-specific roles of neurogenin2 and mashl in GABAergic neuron differentiation in vitoro. (2007)
  • 著者名/発表者名: Jo, AY., et. al.
  • 雑誌名: Experimental cell research 313 ページ: 4066-4081
  • 査読あり
• [雑誌論文] Robol and robo2 control the development of the lateral olfactory tract. (2007)
  • 著者名/発表者名: Fouquet, C., et. al.
  • 雑誌名: J. Neurosci. 27 ページ: 3037-3045
  • 査読あり
• [雑誌論文] Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain. (2007)
  • 著者名/発表者名: Lebel. M
  • 雑誌名: Dev.Biol. 302 ページ: 345-355
• [雑誌論文] Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. (2006)
  • 著者名/発表者名: Satoh W., Gotoh T., Tsunematsu Y., Aizawa S., Shimono A.
  • 雑誌名: Development 133 ページ: 989-999
  • 査読あり
• [雑誌論文] A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. (2006)
  • 著者名/発表者名: Hirano M., Kiyonari H., Inoue A., Furushima K., Murata T., Suda Y., Aizawa S.
  • 雑誌名: Developmental Dynamics 235 ページ: 2229-2237
  • 査読あり
• [雑誌論文] Shisa2 promotes the maturation of somatic precursors and transition to the segmental fate in Xenopus embryos. (2006)
  • 著者名/発表者名: Nagano T., Takehara S., Takahashi M., Aizawa S., Yamamoto, A.
  • 雑誌名: Development 133 ページ: 4643-4654
  • 査読あり
• [雑誌論文] Evolutionary constraint on Otx2 neuroectoderm enhacers-deep conservation from skate to mouse and unique divergence in teleost. (2006)
  • 著者名/発表者名: Kurokawa D., Sakurai Y., Inoue A., Nakayama R., Takasaki N., Suda Y., Miyake T., Amemiya C., Aizawa S.
  • 雑誌名: Proc.Natl.Acad.Sci.USA 103 ページ: 19350-19355
  • 査読あり
• [雑誌論文] Evolutionary constraint on Otx2 neuroectodermenhacers-deep conservation from skate to mouse and uniquedivergence in teleost (2006)
  • 著者名/発表者名: Kurokawa, D., Sakurai, Y., Inoue, A., Nakayama, R., Takasaki, N., Suda, Y., Miyake, T., Amemiya, C. and Aizawa, S
  • 雑誌名: Proc. Natl. Acad. Sci. USA 103 ページ: 19350-19355
  • 査読あり
• [雑誌論文] Sfrp1 and Sfrp2 regulate anteroposterior axia elongation and somite segmentation during mouse embryogenesis. (2006)
  • 著者名/発表者名: Satoh, W. et al.
  • 雑誌名: Development 133 ページ: 989-999
• [雑誌論文] A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. (2006)
  • 著者名/発表者名: Hirano, M. et al.
  • 雑誌名: Developmental Dynamics 235 ページ: 2229-2237
• [雑誌論文] Shisa2 promotes the maturation of somatic precursors and transition to the segmental fate in Xenopus embryos. (2006)
  • 著者名/発表者名: Nagano, T. et al.
  • 雑誌名: Development 133 ページ: 4643-4654
• [雑誌論文] Evolutionary constraint on Otx2 neuroectoderm enhacers-deep conservation from skate to mouse and unique divergence in teleost. (2006)
  • 著者名/発表者名: Kurokawa, D. et al.
  • 雑誌名: PNAS 103 ページ: 19350-19355
• [雑誌論文] The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Drveloping Cerebral Cortex. (2006)
  • 著者名/発表者名: Hirai, S. et al.
  • 雑誌名: The Journal of Neuroscience 26 ページ: 11992-12002
• [雑誌論文] Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells. (2006)
  • 著者名/発表者名: Kasahara, A. et al.
  • 雑誌名: Human Molecular Genetics 15 ページ: 871-881
• [雑誌論文] Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract. (2006)
  • 著者名/発表者名: Kawasaki, T.
  • 雑誌名: Development 133 ページ: 845-853
• [雑誌論文] Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis-sites 90kb apart.
  • 著者名/発表者名: Takasaki, N. et al.
  • 雑誌名: The EMBO Journal (印刷中)
• [学会発表] MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors (2011)
  • 著者名/発表者名: Shinichi Aizawa
  • 学会等名: 2011 Meeting of German Society of Developmental Biologists
  • 発表場所: Dresden, Germany
• [学会発表] Otx1 and Otx2 functions in forebrain and midbrain development. (2010)
  • 著者名/発表者名: Shinichi Aizawa
  • 学会等名: Society for Developmental Biology 69th annual meeting
  • 発表場所: New Mexico, USA
• [学会発表] Conservation of developmental mechanisms in evolutionarily divergent brain structures. (2010)
  • 著者名/発表者名: Tatsumi Hirata
  • 学会等名: SYMPOSIA PARIS meeting 2010, Euro Evo Devo
  • 発表場所: Paris, France
• [学会発表] The adherens junction serves as a switch for neurogenesis via Notch signaling (2010)
  • 著者名/発表者名: Kenji Shimamura
  • 学会等名: Notch and Stem Cells
  • 発表場所: Athens, Greece
• [学会発表] Emergence of the layer structure in the mammalian neocortex associated with a change in the stem cells dynamics (2009)
  • 著者名/発表者名: Tatsumi Hirata
  • 学会等名: Cold Spriing Harbor Laboratory SYMPOSIUM LXXIV, Symoposium on Evolution
  • 発表場所: Cold Spring Harbor, NY
  • 年月日: 2009-05-27
• [学会発表] The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in cortical ventricular zone. (2009)
  • 著者名/発表者名: Shinichi Aizawa
  • 学会等名: 16th International Society of Developmental Biologists Congress.
  • 発表場所: Edinburgh, United Kingdom
• [学会発表] Role of the adherens junction in neurogenesis (2009)
  • 著者名/発表者名: Kenji Shimamura
  • 学会等名: 16^<th> international Society of Developmental Biologists Congress 2009
  • 発表場所: Edinburgh, UK
• [学会発表] Otx2 and A-P axis formation in vertebrates (2008)
  • 著者名/発表者名: Shinichi Aizawa
  • 学会等名: Japan/USA Joint Meeting on Vertebrate Organogenesis
  • 発表場所: Houston, USA
• [学会発表] Axon outgrowth inhibition mediated by four-transmembrane protein M6a. (2008)
  • 著者名/発表者名: Tatsumi Hirata
  • 学会等名: Japan/USA Joint Meeting on Vertebrate Organogenesis
  • 発表場所: San Francisco, USA
• [学会発表] The adherens junction is required for the regulation of neural differentiation (2008)
  • 著者名/発表者名: Kenji Shimamura
  • 学会等名: Frontiers in Developmental Biology
  • 発表場所: Giens Peninsula, France
• [学会発表] Evolutionary constraint on Otx2-neuroectoderm enhancers ; deep conservation from skate to mouse and unique divergence in teleost. (2007)
  • 著者名/発表者名: Shinichi Aizawa
  • 学会等名: FIRST PAN AMERICAN CONGRESS IN DEVELOPMENTAL BIOLOGY
  • 発表場所: Cancun, Mexico
• [学会発表] Otx2 gene cascade in A-P axis formation (2006)
  • 著者名/発表者名: Shinichi Aizawa
  • 学会等名: Monterotondo Mouse Biology Meeting
  • 発表場所: Monterotondo, Italy
• [図書] In Emerging Model Organisms(The Genus Polypterus (Bichirs) ; A fish group diverged at the stem of Ray-finned fishes (Actinopterygii) volume 1) (2009)
  • 著者名/発表者名: Takeuchi M., Okabe M., Aizawa S.
  • 出版者: Cold Spring Harbor Laboratory Press
• [図書] Electroporation and Sonoporation in Dvelopmental Biology.(Method of Electroporation for the Early Chick Embryo.) (2009)
  • 著者名/発表者名: Hatakeyama J., Shimamura K.
  • 出版者: Springer
• [図書] Method of Electroporation for the Early Chick Embryo. In "Electroporation and Sonoporation in Dvelopmental Biology" (2009)
  • 著者名/発表者名: Hatakeyama, J.
  • 総ページ数: 12
  • 出版者: Springer
• [備考] ホームページ
  • URL: http://www.cdb.riken.go.jp/vbp/