サイトカインによる自己応答性の制御

• 研究課題/領域番号: 19059006
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京大学
• 研究代表者: 岩倉 洋一郎 東京大学, 医科学研究所, 教授 (10089120)
• 研究分担者: 西城 忍 東京大学, 医科学研究所, 助教 (60396877) ; 角田 茂 東京大学, 医科学研究所, 助教 (80345032) ; 藤門 範行 東京大学, 医科学研究所, 助教 (90447334)
• 研究期間 (年度): 2007 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 50,400千円 (直接経費: 50,400千円); 2009年度: 16,800千円 (直接経費: 16,800千円); 2008年度: 16,800千円 (直接経費: 16,800千円); 2007年度: 16,800千円 (直接経費: 16,800千円)
• キーワード: IL-1 / IL-17 / 疾患モデル動物 / ノックアウトマウス / C型レクチン / 自己免疫疾患 / 慢性関節リウマチ / 疾患モデルマウス / 炎症性疾患 / サイトカイン / Th17 / IL-17A / 関節リウマチ / IL-17F / 自己応答性 / 獲得免疫

研究概要

関節リウマチ(RA)は、世界人口の約1%が罹患する最も高頻度にみられる自己免疫疾患であり、遺伝、環境因子がともに関与するその病態は非常に複雑で、未だ完全な病態解明には至っていない。我々はこれまでに2種類のRAモデルマウス(HTLV-Iトランスジェニック(Tg)マウス、IL-1Ra欠損(KO)マウス)を作製し、関節炎の発症機構を解析してきた。本研究では、これら2種類のRAモデルマウスを用い、自己免疫発症におけるIL-17ファミリーサイトカインの役割と関節炎モデルで発現亢進がみられたC型レクチンのサイトカイン産生に於ける役割を明らかにする事を目的に研究を行った。その結果、1)IL-17Aは自己免疫,炎症応答などで重要な役割を果たしているが,IL-17Fは炎症応答にはほとんど関与しない事,2)IL-17AもIL-17Fも細菌感染防御で重要な役割を果たしている事,3)Dectin-1はβグルカンの、Dectin-2はαマンナン受容体の受容体であり,これらが樹状細胞を活性化する事によりTh17を誘導し,免疫活性化や真菌感染防御に重要な役割を果たしている事、を明らかにした。これらの成果は新規の免疫治療薬,真菌感染治療薬の開発につながる成果である.

研究成果

• [雑誌論文] Tumor-infiltrating IL-17-producing gammadelta T cells spport the progression of tumor via promoting angiogenesis. (2010)
  • 著者名/発表者名: Wakita, D., Sumida, K., Iwakura, Y., Nishikawa, H., Ohkuri, T., Chamoto, K., Kitamura, H., Nishimura, T.
  • 雑誌名: Eur. J. Immunol. 15(Epub ahead of print)
• [雑誌論文] Stem cell mobilization with G-CSF induces Type-17 differentiation and promotes scleroderma. (2010)
  • 著者名/発表者名: Hill, G.R., Olver, S.D., Kuns, R.D., Varelias, A., Raffelt, N.C., Don, A.L.J., Markey, K.A., Wilson, Y.A., Smyth, M.J., Iwakura, Y., Tocker, J., Clouston, A., MacDonald, K.P.A.
  • 雑誌名: Blood 30(Epub ahead of print)
• [雑誌論文] IFN-γregulates the requirement for IL-17 in proteoglycan-induced arthritis. (2010)
  • 著者名/発表者名: Doodes, P.D., Cao, Y., Hamel, K.M., Wang, Y., Rodeghero, R.I., Mikecz, K., Glant T.T., Iwakura, Y., Finnegan, A.
  • 雑誌名: J. Immunol. 184 ページ: 1552-1559
• [雑誌論文] Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. (2010)
  • 著者名/発表者名: Madhur, M.S., Lob, H.E., McCann, L.A., Iwakura, Y., Blinder, Y., Guzik, T.J., Harrison, D.G.
  • 雑誌名: Hypertension 55 ページ: 500-507
• [雑誌論文] Nucleoprotein diet ameliorates arthritis symptoms in mice transgenic for human T-cell leukemia virus type I (HTLV-I). (2010)
  • 著者名/発表者名: Ohtaki, H., Yufu, S., Nakamachi, T., Satoh, K., Shimizu, A., Mori, H., Sato, A., Iwakura, Y., Matsunaga, M., Shioda, S.
  • 雑誌名: J. Clin. Biochem. Nutr. 46 ページ: 93-104
• [雑誌論文] IFN-γis a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes. (2010)
  • 著者名/発表者名: Kawa, K., Tsutsui, H., Uchiyama, R., Kato, J., Matsui, K., Iwakura, Y., Matsumoto, T., Nakanishi, K.
  • 雑誌名: Int. Immunol. 22 ページ: 157-166
• [雑誌論文] Type I interferon signaling constrains IL-17A/F secretion by gd T cells during bacterial infection. (2010)
  • 著者名/発表者名: Henry, T., Kirimanjeswara, G.S., Ruby, T., Jones, J.W., Peng, K., Perret, M., Ho, L., Sauer, J. -D., Iwakura, Y., Metzger, D.W., Monack, D.M.
  • 雑誌名: J. Immunol. 184 ページ: 3755-67
• [雑誌論文] Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. (2010)
  • 著者名/発表者名: Kono, H., Karmarkar, D., Iwakura, Y., Rock, K.L.
  • 雑誌名: J. Immunol. 184 ページ: 4470-8
• [雑誌論文] Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice. (2010)
  • 著者名/発表者名: Isoda, K., Matsuki, T., Kondo, H., Iwakura, Y., Ohsuzu, F.
  • 雑誌名: Arterioscler. Thromb. Vasc. Biol. 30 ページ: 708-15
• [雑誌論文] IL-17 contributes to the development of chronic rejection in a murine-heart transpant model. (2010)
  • 著者名/発表者名: Itoh, S., Nakae, S., Axtell, R.C., Velotta, J.B., Kimura, N., Kajiwara, N., Iwakura, Y., Saito, H., Adachi, H., Steinman, L., Robbins, R.C., Fishbein, M.P.
  • 雑誌名: J. Clin. Immunol. 30 ページ: 235-40
• [雑誌論文] Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. (2010)
  • 著者名/発表者名: Adamopoulos, I.E., Chao, C.C., Geissler, R., Laface, D., Blumenschein, W., Iwakura, Y., McClanahan, T., Bowman, E.P.
  • 雑誌名: Arthritis Res. Ther. 12
• [雑誌論文] IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. (2010)
  • 著者名/発表者名: Teng, M.W.L., Andrews, D.M., McLaughlin, N., von Scheidt, B., Ngiow, S.F., Moller, A., Hill, G.R., Iwakura, Y., Oft, M., Smyth, M.J.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 107 ページ: 8328-33
• [雑誌論文] Dectin-2 recognition of α-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans. (2010)
  • 著者名/発表者名: Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S., Iwakura, Y.
  • 雑誌名: Immunity 32 ページ: 1-11
• [雑誌論文] IL-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. (2010)
  • 著者名/発表者名: Baldeviano, G.C., Barin, J.G., Talor, M.V., Srinivasan, S., Bedja, D., Zheng, D., Gabrielson, K., Iwakura, Y., Rose, N.R., Cihakova, D.
  • 雑誌名: Circulation Res. 106 ページ: 1645-1655
• [雑誌論文] Th17 cells promote autoimmune anti-myeloperoxidase glomerulomephritits. (2010)
  • 著者名/発表者名: Gan, P.Y., Steinmetz, O.M., Tan, D.S., O'Sullivan, K.M., Ooi, J.D., Iwakura, Y., Kitching, A.R., Holdsworth, S.R.
  • 雑誌名: J. Am. Soc. Nephrol. 21 ページ: 925-931
• [雑誌論文] Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain. (2010)
  • 著者名/発表者名: Cowley, S.C., Meierovics, A.I., Frelinger, J.A., Iwakura, Y., Elkins, K.L.
  • 雑誌名: J. Immunol. 184 ページ: 5791-5801
• [雑誌論文] A Th17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-g production in order to induce airway hyperresponsiveness. (2010)
  • 著者名/発表者名: Ashino, S., Wakita, D., Shiohama, Y., Iwakura, Y., Chamoto, K., Ohkuri, T., Kitamura, H., Nishimura, T.
  • 雑誌名: Int. Immunol. 22 ページ: 503-513
• [雑誌論文] Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. (2010)
  • 著者名/発表者名: Xiao, G., Miyazato, A., Abe, Y., Zhang, T., Nakamura, K., Inden, K., Tanaka, M., Tanno, D., Miyasaka, T., Ishii, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Yamamoto, N., Kunishima, H., Hirakata, Y., Kaku, M., Kawakami, K.
  • 雑誌名: Cellular Immunol. 263 ページ: 241-250
• [雑誌論文] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1β and by down-regulation of suppressor of cytokine signaling 1(SOCS1) (2010)
  • 著者名/発表者名: Shikama, Y.
  • 雑誌名: Innate Immun. (in press)
  • 査読あり
• [雑誌論文] Th17 nephritogenic immunity induces autoimmune anti-MPO glomerulonephritis (2010)
  • 著者名/発表者名: Gan, P.-Y.
  • 雑誌名: J.Am.Soc.Nephrol. (in press)
  • 査読あり
• [雑誌論文] Nucleoprotein diet ameliorates arthritis symptoms in mice transgenic for human T-cell leukemia virus type 1(HTLV-1) (2010)
  • 著者名/発表者名: Ohtaki, H.
  • 雑誌名: J.Clin.Biochem.Nutr. (in press)
  • 査読あり
• [雑誌論文] IFN-γ is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes (2010)
  • 著者名/発表者名: Kawa, K.
  • 雑誌名: Int.Immunol. (in press)
  • 査読あり
• [雑誌論文] Type I interferon signaling constrains IL-17A/F secretion by γδ T cells during bacterial infection (2010)
  • 著者名/発表者名: Henry, T.
  • 雑誌名: J.Immunol. (in press)
  • 査読あり
• [雑誌論文] Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death (2010)
  • 著者名/発表者名: Kono, H.
  • 雑誌名: J.Immunol. (in press)
  • 査読あり
• [雑誌論文] The mechanism of lipopolysaccharide- induced human immunodeficiency virus type I activation in transgenic mouse macrophages (2010)
  • 著者名/発表者名: Kadoki, M.
  • 雑誌名: Int.Immunol. (in press)
  • 査読あり
• [雑誌論文] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1b and by down-regulation of suppressor of cytokine signaling 1 (SOCS1). (2009)
  • 著者名/発表者名: Shikama, Y., Kuroishi, T., Nagai, Y., Iwakura, Y., Shimauchi, H., Takada, H., Sugawara, S., Endo, Y.
  • 雑誌名: Innate Immun. (Epub ahead of print)
• [雑誌論文] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymph nodes and Peyer's patches. (2009)
  • 著者名/発表者名: Bai, Z.B., Hayasaka, H., Kobayashi, M., Li, W., Guo, Z., Jang, M. -H., Kondo, A., Choi, B., Iwakura, Y., Miyasaka, M.
  • 雑誌名: J. Immunol. 182 ページ: 1287-1295
• [雑誌論文] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009)
  • 著者名/発表者名: Ishigame, H., Kakuta, S., Nagai, T., Nambu, A., Komiyama, Y., Kadoki, M., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., Iwakura, Y.
  • 雑誌名: Immunity 30 ページ: 108-119
• [雑誌論文] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice. (2009)
  • 著者名/発表者名: Lopez Kostka, S., Dinges, S., Griewank, K., Iwakura, Y., Udey, M.C., Von Stebut, E.
  • 雑誌名: J. Immunol. 182 ページ: 3039-3046
• [雑誌論文] MHC-matched corneal allograft rejection in an IFN-g/IL-17-independent manner in C57BL/6 mice. (2009)
  • 著者名/発表者名: Yamada, J., Hamuro, J., Fukushima, A., Ohteki, T., Terai, K., Iwakura, Y., Yagita, H., Kinoshita, S.
  • 雑誌名: Invest. Ophthalmol. Vis. Sci. 50 ページ: 2139-2146
• [雑誌論文] Biotin status affects nickel allergy via regulation of IL-1b production in mice. (2009)
  • 著者名/発表者名: Kuroishi, T., Kinbara, M., Sato, N., Tanaka, Y., Nagai, Y., Iwakura, Y., Endo, Y., Sugawara, S.
  • 雑誌名: J. Nutrition 139 ページ: 1031-1036
• [雑誌論文] Host-derived Interleukin-1a is important in determining the immunogenicity of 3-Methylcholantrene-tumor cells. (2009)
  • 著者名/発表者名: Elkabets, M., Krelin, Y., Dotan, S., Cerwenka, A., Porgador, A., Lichtenstein, R.G., White, M.R., Zoller, M., Iwakura, Y., Dinarello, C.A., Voronov, E., Apte, R.N.
  • 雑誌名: J. Immunol. 182 ページ: 4874-4881
• [雑誌論文] Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo. (2009)
  • 著者名/発表者名: Di Paolo, N.C., Miao, E.A., Iwakura, Y., Kaja, M-K., Aderem, A., Flavell, R.A., Papayannopoulou, T., Shayakhmetov, D.M.
  • 雑誌名: Immunity 31 ページ: 110-121
• [雑誌論文] Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans. (2009)
  • 著者名/発表者名: Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NA, Kaku M, Kawakami K.
  • 雑誌名: Infect. Immun. 77 ページ: 3056-3064
• [雑誌論文] Hepatic platelet accumulation in Fas-mediated hepatitis in mice. (2009)
  • 著者名/発表者名: Ohtaki Y, Yamaguchi K, Yu Z, Kumamoto H, Shimauchi H, Iwakura Y, Sugawara S, Endo Y.
  • 雑誌名: Int. Immunopharmacol. 9 ページ: 1071-1078
• [雑誌論文] A protective function for interleukin 17A in T cell-mediated intestinal inflammation. (2009)
  • 著者名/発表者名: O'Connor, W. Jr., Kamanaka, M., Booth, C.J., Town, T., Nakae, S., Iwakura, Y., Kolls, J.K., Flavell, R.A.
  • 雑誌名: Nat. Immunol. 10 ページ: 603-609
• [雑誌論文] IL-17 is involved in bone resorption in mouse periapical lesions. (2009)
  • 著者名/発表者名: Oseko, F., Yamamoto, T., Akamatsu, Y., Kanamura, N., Iwakura, Y., Imanishi, J., Kita, M.
  • 雑誌名: Microbiol. Immunol. 53 ページ: 287-294
  • NAID: 10027686578
• [雑誌論文] Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease. (2009)
  • 著者名/発表者名: Yi, T., Chen, Y., Wang, L., Du, G., Huang, D., Zhao, D., Johnstone, H., Young, J., Todorov, I., Umetsu, D.T., Chen, L., Iwakura, Y., Kandeel, F., Forman, S., Zeng, D.
  • 雑誌名: Blood 114 ページ: 3101-3112
• [雑誌論文] Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling. (2009)
  • 著者名/発表者名: Lindauer, M.L., Wong, J., Iwakura, Y., Magun, B.E.
  • 雑誌名: J. Immunol. 183 ページ: 1419-1426
• [雑誌論文] Pivotal role of cerebral interleukin-17-producing gdT cells in the delayed phase of ischemic brain injury. (2009)
  • 著者名/発表者名: Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D.J., Iwakura, Y., Yoshimura, A.
  • 雑誌名: Nat. Med. 15 ページ: 946-950
• [雑誌論文] Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A. (2009)
  • 著者名/発表者名: Okiyama, N., Sugihara, T., Iwakura, Y., Yokozeki, H., Miyasaka, N., Kohsaka, H.
  • 雑誌名: Arth. Rheum. 60 ページ: 2505-2512
• [雑誌論文] Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia. (2009)
  • 著者名/発表者名: Horino, T., Matsumoto, T., Ishikawa, H., Kimura, S., Uramatsu, M., Tanabe, M., Tateda, K., Miyazaki, S., Aramaki, Y., Iwakura, Y., Yoshida, M., Onodera, S., Yamaguchi, K.
  • 雑誌名: Microbiol. Immunol. 53 ページ: 502-511
  • NAID: 10027687393
• [雑誌論文] T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. (2009)
  • 著者名/発表者名: Horie, I., Abiru, N., Nagayama, Y., Kuriya, G., Saitoh, O., Ichikawa, T., Iwakura, Y., Eguchi, K.
  • 雑誌名: Endocrinology 150 ページ: 5135-5142
  • NAID: 120006983712
• [雑誌論文] Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Fracisella tularensis. (2009)
  • 著者名/発表者名: Lin, Y., Ritchea, S., Logar, A., Slight, S., Messmer, M., Rangel-Moreno, J., Guglani, L., Alcorn, J. F., Strawbridge, H., Park, S. M., Onishi, R., Nyugen, N., Walter, M. J., Pociask, D., Randall, T. D., Gaffen, S. L., Iwakura, Y., Kolls, J. K., Khader, S. A*.
  • 雑誌名: Immunity 31 ページ: 799-810
• [雑誌論文] Natural occurring IL-17 producing T cells regulagte the initial phase of neutrophil mediated airway responses. (2009)
  • 著者名/発表者名: Tanaka, S., Yoshimoto, T., Naka, T., Nakae, S., Iwakura, Y., Cua, D., Kubo, M.
  • 雑誌名: J. Immunol. 183 ページ: 7523-7530
• [雑誌論文] Role of T cell TGFβsignaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. (2009)
  • 著者名/発表者名: Faust, S.M., Lu, G., Marini, B.L., Zou, W., Gordon, D., Iwakura, Y., Laouar, Y., Bishop, D.K.
  • 雑誌名: J. Immunol. 183 ページ: 7297-7306
• [雑誌論文] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis. (2009)
  • 著者名/発表者名: Oyamada, A., Ikebem H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K.I., Iwamoto, Y., Yoshikai, Y., Yamada, H.
  • 雑誌名: J. Immunol. 183 ページ: 7539-7546
• [雑誌論文] Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. (2009)
  • 著者名/発表者名: Munoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R.,Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., Loddenkemper, C., Krell, H. -W., Libert, C., Lund, L. R., Frey, O., Holscher, C., Iwakura, Y., Ghilardi, N., Ouyang, W., Kamradt, T., Sabat, R., Liesenfeld, O. Interleukin
  • 雑誌名: J. Exp. Med. 206 ページ: 3047-3059
• [雑誌論文] MHC-matched corneal allograft rejection in an IFN-γ/IL-17-independent manner in C57BL/6 mice (2009)
  • 著者名/発表者名: Yamada, J.
  • 雑誌名: Invest.Ophthalmol.Vis.Sci. 50 ページ: 2139-2146
  • 査読あり
• [雑誌論文] Biotin status affects nickel allergy via regulation of IL-1β production in mice (2009)
  • 著者名/発表者名: Kuroishi, T.
  • 雑誌名: J.Nutrition 139 ページ: 1031-1036
  • 査読あり
• [雑誌論文] Host-derived Interleukin-1α is important in determining the immunogenicity of 3-Methylcholantrene-tumor cells (2009)
  • 著者名/発表者名: Elkabets, M.
  • 雑誌名: J.Immunol. 182 ページ: 4874-4881
  • 査読あり
• [雑誌論文] Virus sensing at the plasma membrane triggers interleukin-1α-mediated pro-inflammatory macrophage response (2009)
  • 著者名/発表者名: Di Paolo, N.C.
  • 雑誌名: Immunity 31 ページ: 110-121
  • 査読あり
• [雑誌論文] Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans (2009)
  • 著者名/発表者名: Miyazato A
  • 雑誌名: Infect.Immun. 77 ページ: 3056-3064
  • 査読あり
• [雑誌論文] A protective function for interleukin 17A in T cell-mediated intestinal inflammation (2009)
  • 著者名/発表者名: O'Connor, W.Jr.
  • 雑誌名: Nat.Immunol. 10 ページ: 603-609
  • 査読あり
• [雑誌論文] IL-17 is involved in bone resorption in mouse periapical lesions (2009)
  • 著者名/発表者名: Oseko, F.
  • 雑誌名: Microbiol Immunol. 53 ページ: 287-294
  • 査読あり
• [雑誌論文] Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease (2009)
  • 著者名/発表者名: Yi, T., Chen
  • 雑誌名: Blood 114 ページ: 3101-3112
  • 査読あり
• [雑誌論文] Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia (2009)
  • 著者名/発表者名: Horino, T.
  • 雑誌名: Microbiol.Immunol. 53 ページ: 502-511
  • 査読あり
• [雑誌論文] Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Fracisella tularensis (2009)
  • 著者名/発表者名: Lin, Y.
  • 雑誌名: Immunity 31 ページ: 799-810
  • 査読あり
• [雑誌論文] Natural occurring IL-17 producing T cells regulagte the initial phase of neutrophil mediated airway responses (2009)
  • 著者名/発表者名: Tanaka, S.
  • 雑誌名: J.Immunol. 183 ページ: 7523-7530
  • 査読あり
• [雑誌論文] Role of T cell TGFβ signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection (2009)
  • 著者名/発表者名: Faust, S.M., Lu, G., Marini, B.L., Zou, W., Gordon, D., Iwakura, Y., Laouar, Y., Bishop, D.K.
  • 雑誌名: J.Immunol. 183 ページ: 7297-7306
  • 査読あり
• [雑誌論文] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis (2009)
  • 著者名/発表者名: Oyamada, A.
  • 雑誌名: J.Immunol. 183 ページ: 7539-7546
  • 査読あり
• [雑誌論文] Interleukin(IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17 (2009)
  • 著者名/発表者名: Munoz, M.
  • 雑誌名: J.Exp.Med. 206 ページ: 3047-3059
  • 査読あり
• [雑誌論文] IFN-g regulates the requirement for IL-17 in proteoglycan-induced arthritis (2009)
  • 著者名/発表者名: Doodes, P.D.
  • 雑誌名: J.Immunol. 184 ページ: 1552-1559
  • 査読あり
• [雑誌論文] IFN-y expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death (2009)
  • 著者名/発表者名: Atsumi, T.
  • 雑誌名: Int. Immunol. 21 ページ: 73-80
  • 査読あり
• [雑誌論文] IL-17 contributes to CD4-mediated graft-versus-host disease (2009)
  • 著者名/発表者名: Kappel, L. W.
  • 雑誌名: Blood 113 ページ: 945-952
  • 査読あり
• [雑誌論文] Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mixbackground (2009)
  • 著者名/発表者名: Chida, D.
  • 雑誌名: Mol. Cell. Endocrinol. 300 ページ: 32-36
  • 査読あり
• [雑誌論文] IL-1 regulates the Cyp7al gene and serum total cholesterol level at steady state in mice (2009)
  • 著者名/発表者名: Kojima, M.
  • 雑誌名: Biochem. Biophys. Res. Commun. 279 ページ: 239-242
  • 査読あり
• [雑誌論文] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses (2009)
  • 著者名/発表者名: Ishigame, H.
  • 雑誌名: Immunity 29 ページ: 628-636
  • 査読あり
• [雑誌論文] Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis (2009)
  • 著者名/発表者名: Irie, N.
  • 雑誌名: J Biol Chem (in press)
  • 査読あり
• [雑誌論文] Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma (2009)
  • 著者名/発表者名: Yoneda, M.
  • 雑誌名: Cancer Sci. (in press)
  • 査読あり
• [雑誌論文] IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice. (2008)
  • 著者名/発表者名: Kojima, M., Ashino, T., Yoshida, T., Iwakura, Y., Sekimoto, M., Degawa, M.
  • 雑誌名: Biochem. Biophys. Res. Commun. 379 ページ: 239-242
• [雑誌論文] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. (2008)
  • 著者名/発表者名: Okumura, A., Saito, T., Otani, I., Kojima, K., Yamada, Y., Ishida-Okawara, A., Nakazato, K., Asano, M., Kanayama, K., Iwakura, Y., Suzuki, K., Yamagoe, S.
  • 雑誌名: Arthritis Rheum. 58 ページ: 413-421
• [雑誌論文] Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. (2008)
  • 著者名/発表者名: Fujikado, N., Saijo, S., Yonezawa, T., Shimamori, K., Ishii, A., Sugai, S., Kotaki, H., Sudo, K., Nose, M., Iwakura, Y.
  • 雑誌名: Nat. Med. 14 ページ: 176-180
• [雑誌論文] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. (2008)
  • 著者名/発表者名: Ashino, T., Yamanaka, R., Yamamoto, M., Shimokawa, H., Sekikawa, K., Iwakura, Y., Shioda, S., Numazawa, S., Yoshida, T.
  • 雑誌名: Mol. Immunol. 45 ページ: 2106-2115
• [雑誌論文] Differential roles for IFN-g and IL-17 in experimental autoimmune uveoretinitis. (2008)
  • 著者名/発表者名: Yoshimura, T., Sonoda, K., Miyazaki, Y., Iwakura, Y., Ishibashi, T., Yoshimura, A., Yoshida, H.
  • 雑誌名: Int. Immunol. 20 ページ: 209-214
• [雑誌論文] Interleukin-1b and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA induced matrix metalloproteinase-1 expression. (2008)
  • 著者名/発表者名: Honda, A., Abe, R., Makino, T., Norisugi, O., Fujita, Y., Watanabe, H., Nishihira, J., Yamagishi, S., Iwakura, Y., Shimizu, H., Shimizu, T.
  • 雑誌名: J. Dermatol. Sci. 49 ページ: 63-72
• [雑誌論文] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of Natural Killer T cells and IL-17. (2008)
  • 著者名/発表者名: Pichavant, M., Goya, S., Meyer, E.H., Johnston, R.A., Kim, H.Y., Matangkasombut, P., Zhu, M., Iwakura, Y., Savage, P.B., DeKruyff, R.H., Shore, S.A., Umetsu, D.T.
  • 雑誌名: J. Exp. Med. 205 ページ: 385-393
• [雑誌論文] Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. (2008)
  • 著者名/発表者名: Nakamura, K., Miyazato, A., Gang, X., Hatta, M., Inden, K., Aoyagi, T., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Suzuki, K., Fujita, J., Kaku, M., Kawakami, K.
  • 雑誌名: J. Immunol. 180 ページ: 4067-4074
• [雑誌論文] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. (2008)
  • 著者名/発表者名: Aujla, S.J., Fei, M., Pociask, D.A., Reinhart, T.A., Edeal, J., Gaus, K., Kreindler, J.L., Dubin, P.J., Zheng, M., Pilewski, J.M., Myerburg, M.M., Mason, C.A., Iwakura, Y., Kolls, J.K.
  • 雑誌名: Nature Med. 14 ページ: 275-281
• [雑誌論文] Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. (2008)
  • 著者名/発表者名: Luger, D., Silver, P.B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E.P., Sgambellone, N.M., Chan, C. -C., Caspi, R.R.
  • 雑誌名: J. Exp. Med. 205 ページ: 799-810
• [雑誌論文] Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis. (2008)
  • 著者名/発表者名: Fukushima, A., Sumi, T., Ishida, W., Yamada, J., Iwakura, Y., Ueno, H.
  • 雑誌名: Int. Arch. Allergy Imm. 147 ページ: 206-212
• [雑誌論文] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. (2008)
  • 著者名/発表者名: Izcue, A., Hue, S., Buonocore, S., Arancibia-Carcamo, C.V., Ahern, P.P., Iwakura, Y., Maloy, K.J., Powrie, F
  • 雑誌名: Immunity 28 ページ: 559-570
• [雑誌論文] L-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells (2008)
  • 著者名/発表者名: Tajima, M., Wakita, D., Noguchi, D., Chamoto, K., Yue, Z, Fugo, K., Ishigame, H., Iwakura, Y., Kitamura, H., Nishimura, T.
  • 雑誌名: J. Exp. Med. 205 ページ: 1019-1027
• [雑誌論文] CD44 and Bak expression in IL-6 or TNF-a gene knockout mice after whole lung irradiation. (2008)
  • 著者名/発表者名: Sakai, M., Iwakawa, M., Iwakura, Y., Ohta, T., Tsujii, H., Imai, T.
  • 雑誌名: J. Radiat. Res. 49 ページ: 409-416
• [雑誌論文] Development of proteogylcan-induced arthritis is independent of IL-17. (2008)
  • 著者名/発表者名: Doodes, P.D., Cao, Y., Hamel, K., Wang, Y., Hutas, G., Iwakura, Y., Finnegan, A.
  • 雑誌名: J. Immunol. 181 ページ: 329-337
• [雑誌論文] CCL2 recruitment of IL-6 producing CD11b+ monocytes to the draining lymph nodes during the initiation of TH17-dependent B cellmediated autoimmunity. (2008)
  • 著者名/発表者名: Bai, Y, Liu, R., Huang, D., La Cava, A., Tang, Y., Iwakura, Y., Campagnolo, D.I., Vollmer, T.L., Ransohoff, R.M., Shi, F.
  • 雑誌名: Eur. J. Immunol. 38 ページ: 1877-1888
• [雑誌論文] Host T cells are the main producers of IL-17 within the central nervous system during initiation of experimental autoimmune encephalomyelitis induced by adoptive transfer of Th1 cell lines. (2008)
  • 著者名/発表者名: Lees, J.R., Iwakura, Y., Russell, J.H.
  • 雑誌名: J. Immunol. 180 ページ: 8066-8072
• [雑誌論文] Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. (2008)
  • 著者名/発表者名: Ogura H., Murakami, M., Okyuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., Hirano, T*.
  • 雑誌名: Immunity 29 ページ: 628-636
• [雑誌論文] IL-17A is produced by Th17 cells, γδ T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. (2008)
  • 著者名/発表者名: Schulz, S.M., Kohler, G., Holscher, C., Iwakura, Y., Alber, G*.
  • 雑誌名: Int. Immunol. 9 ページ: 1129-1138
• [雑誌論文] Contribution of IL-1 to resistance to Streptococcus pneumoniae infection. (2008)
  • 著者名/発表者名: Kafka, D., Ling, E., Feldman, G., Benharroch, D., Voronov, E., Givon-Laci, N., Iwakura, Y., Dagan, R., Apte, R.N., Mizrachi-Nebenzahi, Y.
  • 雑誌名: Int. Immunol. 9 ページ: 1139-1146
  • NAID: 10022599302
• [雑誌論文] Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei. (2008)
  • 著者名/発表者名: Nakamura, K., Miyazato, A., Koguchi, Y., Adachi, Y., Ohno, N., Saijo, S., Iwakura, Y., Takeda, K., Akira, S., Fujita, J., Ishii, K., Kaku, M., Kawakami, K.
  • 雑誌名: Microbes Infect. 10 ページ: 1223-1227
• [雑誌論文] IL-17 is Involved in Helicobacter pylori-Induced Gastric Inflammatory Responses in a Mouse Model. (2008)
  • 著者名/発表者名: Shiomi, S., Toriie, A., Imamura, S., Konishi, H., Mitsufuji, S., Iwkaura, Y., Yamaoka, Y., Ota, H., Yamamoto, T., Imanishi, J., Kita, M.
  • 雑誌名: Helicobacter 13 ページ: 518-524
• [雑誌論文] The roles of IL-17A in inflammatory immune responses and host defense against pathogens. (2008)
  • 著者名/発表者名: Iwakura, Y., Nakae, S., Saijo, S., Ishigame, H.
  • 雑誌名: Immunological Rev. 226 ページ: 57-79
• [雑誌論文] L-17A produced by gammadelta T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. (2008)
  • 著者名/発表者名: Hamada, S., Umemura, M., Shiono, T., Tanaka, K., Yahagi, A., Begum, M.D., Oshiro, K., Okamoto, Y., Watanabe, H., Kawakami, K., Roark, C., Born, W.K., O'Brien, R., Ikuta, K., Ishikawa, H., Nakae, S., Iwakura, Y., Ohta, T., Matsuzaki, G.
  • 雑誌名: J. Immunol. 181 ページ: 3456-3463
• [雑誌論文] Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. (2008)
  • 著者名/発表者名: Ito, R., Kita, M., Shin-Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Iwakura, Y., Okanoue, T., Yoshikawa, T., Kataoka, K., Mazda, O.
  • 雑誌名: Biochem. Biophys. Res. Commun. 377 ページ: 12-16
• [雑誌論文] Deficiency of tumor necrosis factor-a and interferon-g in bone marrow cells synergistically inhibits neointimal formation following vascular injury. (2008)
  • 著者名/発表者名: Murayama, H., Takahashi, M., Takamoto, M., Shiba, Y., Ise, H., Koyama, J., Tagawa, Y., Iwakura, Y., Ikeda, U.
  • 雑誌名: Cardiovascular Res. 80 ページ: 175-180
• [雑誌論文] IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice. (2008)
  • 著者名/発表者名: Wakashin, H., Hirose, K., Maezawa, Y., Kagami, S., Suto, A., Watanabe, N., Saito, Y., Hatano, M., Tokuhisa, T., Iwakura, Y., Puccetti, P., Iwamoto, I., Nakajima, H.
  • 雑誌名: Am. J. Respir. Crit. Care Med. 178 ページ: 1023-1032
• [雑誌論文] Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules. (2008)
  • 著者名/発表者名: Teruya, H., Tomita, M., Senba, M., Ishikawa, C., Tamayose, M., Miyazato, A., Yara, S., Tanaka, Y., Iwakura, Y., Fujita, J., Mori, N.
  • 雑誌名: Retrovirology 5 ページ: 86-86
  • NAID: 120001374675
• [雑誌論文] IL-17 contributes to CD4-mediated graft-versus-host disease. (2008)
  • 著者名/発表者名: Kappel, L.W., Goldberg, G.L., King, C.G., Suh, D., Smith, O.M., Ligh, C., Holland, A., Grubin, J., Liu, C., Iwakura, Y., Mark, N., Heller, G., van den Brink, M.R.M.
  • 雑誌名: Blood 113 ページ: 628-636
• [雑誌論文] Protective immunity to systemic infection with Salmonella enterica serovar Enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22 but not IL-17. (2008)
  • 著者名/発表者名: Schulz, S.M., Kohler, G., Schutze, N., Knauer, J., Straubinger, R.K., Chackerian, A.A., Witte, E., Wolk, K., Sabat, R., Iwakura, Y., Holscher, C., Muller, U., Kastelein, R.A., Alber, G.
  • 雑誌名: J. Immunol. 181 ページ: 7891-7901
• [雑誌論文] Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1a released from dying cells. (2008)
  • 著者名/発表者名: Eigenbrod, T., Park, J-H., Harder, J., Iwakura, Y., Nunez, G.
  • 雑誌名: J. Immunol. 181 ページ: 8194-8198
• [雑誌論文] IFN-γexpression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. (2008)
  • 著者名/発表者名: Atsumi, T., Sato, M., Kamimura, D., Moroi, A., Iwakura, Y., Betz, U.A., Yoshimura, A., Nishihara, M., Hirano, T., Murakami, M.
  • 雑誌名: Int. Immunol. 21 ページ: 73-80
  • NAID: 10025383990
• [雑誌論文] Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression (2008)
  • 著者名/発表者名: Honda, A.
  • 雑誌名: J. Dermatol. Sci. 49 ページ: 63-72
  • 査読あり
• [雑誌論文] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II rollacren antibody-induced arthritis (2008)
  • 著者名/発表者名: Okumura, A.
  • 雑誌名: Arthritis Rheum. 58 ページ: 413-421
  • 査読あり
• [雑誌論文] Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinits (2008)
  • 著者名/発表者名: Yoshimura, T.
  • 雑誌名: Int. Immunol. 20 ページ: 209-214
  • 査読あり
• [雑誌論文] Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells (2008)
  • 著者名/発表者名: Fuji kado, N.
  • 雑誌名: Nap. Med. 14 ページ: 176-180
  • 査読あり
• [雑誌論文] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages (2008)
  • 著者名/発表者名: Ashino, T.
  • 雑誌名: Mol. Immunol. 45 ページ: 2106-2115
  • 査読あり
• [雑誌論文] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17 (2008)
  • 著者名/発表者名: Pichavant, M.
  • 雑誌名: J. Exp. Med. 205 ページ: 385-393
  • 査読あり
• [雑誌論文] Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway (2008)
  • 著者名/発表者名: Nakamura, K.
  • 雑誌名: J. Immunol. 180 ページ: 6067-4074
  • 査読あり
• [雑誌論文] Kid-Mediated Chromosome Compaction Ensures Proper Nuclear Envelope Formation (2008)
  • 著者名/発表者名: Ohsugi, M.
  • 雑誌名: Cell 132 ページ: 771-782
  • 査読あり
• [雑誌論文] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia (2008)
  • 著者名/発表者名: Aujia, S. J.
  • 雑誌名: Nat. Med. 14 ページ: 275-281
  • 査読あり
• [雑誌論文] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis (2008)
  • 著者名/発表者名: Izcue, A.
  • 雑誌名: Immunity 28 ページ: 559-570
  • 査読あり
• [雑誌論文] Either a Th17 or a Th1 effector response can drive autoimmunity : conditions of disease induction affect dominant effector category (2008)
  • 著者名/発表者名: Luger, D.
  • 雑誌名: J. Exp. Med. 205 ページ: 799-810
  • 査読あり
• [雑誌論文] IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells (2008)
  • 著者名/発表者名: Tajima, M.
  • 雑誌名: J. Exp. Med. 205 ページ: 1019-1027
  • 査読あり
• [雑誌論文] Host T Cells Are the Main Producers of IL-17 within the Central Nervous System during Initiation of Experimental Autoimmune Encephalomyelitis Induced by Adoptive Transfer of Thl Cell Lines (2008)
  • 著者名/発表者名: Lees, J. R.
  • 雑誌名: J. Immunol. 180 ページ: 8066-8072
  • 査読あり
• [雑誌論文] Development of Proteoglycan-Induced Arthritis Is Independent of IL-17 (2008)
  • 著者名/発表者名: Doodes, P. D.
  • 雑誌名: J. Imrnunol. 181 ページ: 329-337
  • 査読あり
• [雑誌論文] CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymphnodes during the initiation of Th17-dependent B cell-mediated autoimmunity (2008)
  • 著者名/発表者名: Bai, Y.
  • 雑誌名: Eur. J. Immunol. 38 ページ: 1877-1888
  • 査読あり
• [雑誌論文] Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding (2008)
  • 著者名/発表者名: Kubota, N.
  • 雑誌名: Cell Metab. 8 ページ: 49-64
  • 査読あり
• [雑誌論文] Endogenous IL-17 Does Not Play a Significant Role in the Development of Experimental Murine Allergic Conjunctivitis (2008)
  • 著者名/発表者名: Fukushima, A.
  • 雑誌名: Int. Arch. Allergy Immunol. 147 ページ: 206-212
  • 査読あり
• [雑誌論文] CD44 and Bak Expression in IL-6 or TNF-a Gene Knockout Mice After Whole Lung Irradiation (2008)
  • 著者名/発表者名: Sakai, M.
  • 雑誌名: J. Radiat. Res. (Tokyo) 49 ページ: 409-416
  • 査読あり
• [雑誌論文] Increased fat : carbohydrate oxidation ratio in mice on a high fat diet is associated with increased sympathetic tone (2008)
  • 著者名/発表者名: Chida, D.
  • 雑誌名: Diabetologia 51 ページ: 1698-1706
  • 査読あり
• [雑誌論文] IL-17A is produced by Th17, yST cells and other CD4-lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance (2008)
  • 著者名/発表者名: Schulz, S. M.
  • 雑誌名: Int. Immunol. 20 ページ: 1129-1138
  • 査読あり
• [雑誌論文] Contribution of IL-1 to resistance to Streptococcus pneumoniae infection (2008)
  • 著者名/発表者名: Kafka, D.
  • 雑誌名: Int. Immunol. 20 ページ: 1139-1146
  • 査読あり
• [雑誌論文] IL-17A Produced by yOT Cells Plays a Critical Role in Innate Immunity against Listeria monocyto genes Infection in the Liver (2008)
  • 著者名/発表者名: Hamada, S.
  • 雑誌名: J. Immunol. 181 ページ: 3456-3463
  • 査読あり
• [雑誌論文] Human T-cell leukemia virus type I infects human lung epithelial cells and inducesgene expression of cytokines, chemokines and cell adhesion molecules (2008)
  • 著者名/発表者名: Teruya, H.
  • 雑誌名: Retrovirology 5 ページ: 86-86
  • 査読あり
• [雑誌論文] Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction (2008)
  • 著者名/発表者名: Ogura, H.
  • 雑誌名: Immunity 29 ページ: 628-636
  • 査読あり
• [雑誌論文] Deficiency of Tumor Necrosis Factor-α and Interferon-γ in Bone Marrow Cells Synergistically Inhibits Neointimal Formation Following Vascular Injury (2008)
  • 著者名/発表者名: Murayama, H.
  • 雑誌名: Cardiovasc. Res. 80 ページ: 175-180
  • 査読あり
• [雑誌論文] Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei (2008)
  • 著者名/発表者名: Nakamura, K.
  • 雑誌名: Microbes Infect. 10 ページ: 1223-1227
  • 査読あり
• [雑誌論文] IL-23 and Th17 Cells Enhance Th2 Cell-mediated Eosinophilic Airway Inflammation in Mice. Am. J. Respir (2008)
  • 著者名/発表者名: Wakashin, H.
  • 雑誌名: Crit. Care Med. 178 ページ: 1023-1032
  • 査読あり
• [雑誌論文] Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice (2008)
  • 著者名/発表者名: Ito, R.
  • 雑誌名: Biochem. Biophys.Res. Commun. 377 ページ: 12-16
  • 査読あり
• [雑誌論文] Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17 (2008)
  • 著者名/発表者名: Schulz, S. M.
  • 雑誌名: J. Immunol. 181 ページ: 7891-7901
  • 査読あり
• [雑誌論文] Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells (2008)
  • 著者名/発表者名: Eigenbrod, T.
  • 雑誌名: J. Immunol. 181 ページ: 8194-8198
  • 査読あり
• [雑誌論文] IL-17 is Involved in Helicobacter pylori-Induced Gastric Inflammatory Responses in a Mouse Model (2008)
  • 著者名/発表者名: Shiomi, S.
  • 雑誌名: Helicobacter 13 ページ: 518-524
  • 査読あり
• [雑誌論文] The roles of IL-17A in inflammatory immune responses and host defense against pathogens (2008)
  • 著者名/発表者名: Iwakura, Y.
  • 雑誌名: Immanol. Rev. 226 ページ: 57-79
  • 査読あり
• [雑誌論文] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. (2008)
  • 著者名/発表者名: Izcue A.
  • 雑誌名: Immunity 28 ページ: 559-570
  • 査読あり
• [雑誌論文] Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. (2008)
  • 著者名/発表者名: Luger D.
  • 雑誌名: J Exp Med 205 ページ: 799-810
  • 査読あり
• [雑誌論文] Kid-mediated chromosome compaction ensures proper nuclear envelope formation. (2008)
  • 著者名/発表者名: Ohsugi M.
  • 雑誌名: Cell 132 ページ: 771-782
  • 査読あり
• [雑誌論文] Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway. (2008)
  • 著者名/発表者名: Nakamura K.
  • 雑誌名: J Immunol 180 ページ: 4067-4074
  • 査読あり
• [雑誌論文] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. (2008)
  • 著者名/発表者名: Aujla SJ.
  • 雑誌名: Nat Med 14 ページ: 275-281
  • 査読あり
• [雑誌論文] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. (2008)
  • 著者名/発表者名: Pichavant M.
  • 雑誌名: J Exp Med 205 ページ: 385-393
  • 査読あり
• [雑誌論文] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. (2008)
  • 著者名/発表者名: Okamura A.
  • 雑誌名: Arthritis Rheum 58 ページ: 413-421
  • 査読あり
• [雑誌論文] Dcir deficiency causes davelopment of autoimmune diseases in mice due to excess expansion of dendritic cells. (2008)
  • 著者名/発表者名: Fujikado N.
  • 雑誌名: Nat Med 14 ページ: 176-180
  • 査読あり
• [雑誌論文] Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. (2008)
  • 著者名/発表者名: Yoshimura T.
  • 雑誌名: Int Immunol 20 ページ: 209-214
  • 査読あり
• [雑誌論文] Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression. (2008)
  • 著者名/発表者名: Honda A.
  • 雑誌名: J Dermal Sci 49 ページ: 63-72
  • 査読あり
• [雑誌論文] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages (2008)
  • 著者名/発表者名: Ashino T.
  • 雑誌名: Mol Immunol 45 ページ: 2106-2115
  • 査読あり
• [雑誌論文] Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism. (2007)
  • 著者名/発表者名: Kamari, Y., Werman-Venkert, R., Shaish, A., Werman, A., Harari, A., Gonen, A., Voronov, E., Grosskopf, I., Sharabi, Y., Grossman, E., Iwakura, Y., Dinarello, C.A., Apte, R.N., Harats, D.
  • 雑誌名: Atherosclerosis 195 ページ: 31-38
• [雑誌論文] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. (2007)
  • 著者名/発表者名: Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T., Yamamoto, T.
  • 雑誌名: Eur. J. Neurosci. 26 ページ: 2269-2278
• [雑誌論文] Knockout mice lacking cPGES/p23, a constitutively expressed PGE(2) synthetic enzyme, are peri-natally lethal. (2007)
  • 著者名/発表者名: Nakatani, Y., Hokonohara, Y., Kakuta, S., Sudo, K., Iwakura, Y., Kudo, I.
  • 雑誌名: Biochem. Biophys. Res. Commun. 362 ページ: 387-92
• [雑誌論文] Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. (2007)
  • 著者名/発表者名: Kayasuga, Y., Chiba, S., Suzuki, M., Kikusui, T., Matsuwaki, T., Yamanouchi, K., Kotaki, H., Horai, R., Iwakura, Y., Nishihara, M.
  • 雑誌名: Behav. Brain Res. 185 ページ: 110-118
• [雑誌論文] Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice. (2007)
  • 著者名/発表者名: Kagari, T., Tanaka, D., Doi, H., Iwakura, Y., Shimozato, T.
  • 雑誌名: Eur. J. Immunol. 37 ページ: 2753-2763
• [雑誌論文] Melanocortin receptor 2 is required for adrenal gland development, steroidogenesis and neonatal gluconeogenesis. (2007)
  • 著者名/発表者名: Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M., Iwakura, Y.
  • 雑誌名: Proc. Natl. Acad. Sci. USA 104 ページ: 18205-18210
• [雑誌論文] Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a Th17-independent manner. (2007)
  • 著者名/発表者名: Noguchi, D., Wakita, D., Tajima, M., Ashino, S., Iwakura, Y., Zhang, Y., Chamoto, K., Kitamura, H., Nishimura, T.
  • 雑誌名: Int. Immunol. 19 ページ: 1431-1440
• [雑誌論文] Inflammasome-mediated production of IL-1b is required for neutrophil recruitment against Staphylococcus aureus in vivo. (2007)
  • 著者名/発表者名: Miller, L.S., Pietras, E.M., Uricchio, L.H., Hirano, K., Rao, S., Lin, H., O'Connell, R.M., Iwakura, Y., Cheung, A.L., Cheng, G., Modlin, R.L.
  • 雑誌名: J. Immunol. 179 ページ: 6933-6942
• [雑誌論文] Dectin-1 is not required for the host defense to Cryptococcus neoformans. (2007)
  • 著者名/発表者名: Nakamura K.
  • 雑誌名: Microbiol Immunol 51 ページ: 1115-1119
  • 査読あり
• [雑誌論文] Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis and neonatal gluconeogenesis. (2007)
  • 著者名/発表者名: Chida D.
  • 雑誌名: Proc Natl Acad Sci USA 104 ページ: 18205-18210
  • 査読あり
• [雑誌論文] Inflammasome-mediated production of IL-1β is required for neutrophil recruitment against Staphylococcus aureus in vivo. (2007)
  • 著者名/発表者名: Miller LS.
  • 雑誌名: J Immunol 179 ページ: 6933-6942
  • 査読あり
• [雑誌論文] Blocking of IL-6 signaling pathway prevents CD4+T cell-mediated colitis in a Th17-independent manner. (2007)
  • 著者名/発表者名: Noguchi D.
  • 雑誌名: Int Immunol 19 ページ: 1431-1440
  • 査読あり
• [雑誌論文] Peripheral TNFα, but not peripheral IL-1, requires endogenous IL-1 or TNFα induction in the brain for the febrile response. (2007)
  • 著者名/発表者名: Chida D.
  • 雑誌名: Biochem Biophys Res Commun 364 ページ: 765-770
  • 査読あり
• [雑誌論文] Anti-type II collagen antibody accelerates arthritis via CXCR2-expressillg ceells in IL-1 receptor antagonist-deficient mice. (2007)
  • 著者名/発表者名: Kagari T.
  • 雑誌名: Eur J Immunol 37 ページ: 2269-2278
  • 査読あり
• [雑誌論文] IL-23 enhances host defense against vaccinia virus infection via amechanism partly involving IL-17. (2007)
  • 著者名/発表者名: Kohyama S.
  • 雑誌名: J Immunol 179 ページ: 3917-3925
  • 査読あり
• [雑誌論文] Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12 (2007)
  • 著者名/発表者名: Kaiga T.
  • 雑誌名: J Immunol 178 ページ: 7571-7580
  • 査読あり
• [雑誌論文] Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by iipopolvsaccharide in vivo. (2007)
  • 著者名/発表者名: Takagi K.
  • 雑誌名: Nitric Oxide 16 ページ: 433-441
  • 査読あり
• [雑誌論文] IFN-γ protects cerulein-induced acute pancreatitis by repressing NF-κB activation. (2007)
  • 著者名/発表者名: Hayashi T.
  • 雑誌名: J Immunol 178 ページ: 7385-7394
  • 査読あり
• [雑誌論文] The adaptor protein CARD9 is essential for the activation of myeloid cells througb ITAM-associated and Toll-like receptors. (2007)
  • 著者名/発表者名: Hara H.
  • 雑誌名: Nat Immunol 8 ページ: 619-629
  • 査読あり
• [雑誌論文] Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. (2007)
  • 著者名/発表者名: Venkataraman T.
  • 雑誌名: J Immunol 178 ページ: 6444-6455
  • 査読あり
• [雑誌論文] Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase. (2007)
  • 著者名/発表者名: Sato N.
  • 雑誌名: Clin Exp Allergy 37 ページ: 743-751
  • 査読あり
• [雑誌論文] IL-28 elicits antitumor responses against murine fibrosarcoma. (2007)
  • 著者名/発表者名: Numasaki M.
  • 雑誌名: J Immunol 178 ページ: 5086-5098
  • 査読あり
• [雑誌論文] A new murine model to define the critical pathologic and therapeutic mediators of polvmvositis. (2007)
  • 著者名/発表者名: Sugihara T.
  • 雑誌名: Arthritis Rheum 56 ページ: 1304-1314
  • 査読あり
• [雑誌論文] Natural killer T cells from interleukin-4-deficient mice are defective in earlyinterferon-y production in response to α-galactosylceramide. (2007)
  • 著者名/発表者名: Togashi Y.
  • 雑誌名: Cancer Sci 98 ページ: 721-725
  • 査読あり
• [雑誌論文] IL-17-mediated regulation of innate and acquired immune response against pulmonarv Mvcobacterium boyis bacille Calmette-Guerin infection. (2007)
  • 著者名/発表者名: Umemura M.
  • 雑誌名: J Immunol 178 ページ: 3786-3796
  • 査読あり
• [雑誌論文] Role of interferon-y in Va14+ natural killer T cell-mediated host defenseagainst Streptococcus pneumoniae infection in murine lungs. (2007)
  • 著者名/発表者名: Nakamatsu M.
  • 雑誌名: Microbes Infect 9 ページ: 364-374
  • 査読あり
• [雑誌論文] Phenotypic differences between Th1 and Th17 cells and negative regulation of Thl cell differentiation bv IL-17 (2007)
  • 著者名/発表者名: Nakae S.
  • 雑誌名: J Leukocyte Biol 81 ページ: 1258-1268
  • 査読あり
• [雑誌論文] Intestinal inflammation downregulates smooth muscle CPI-17 throughinduction of TNF-α and causes motility disorders. (2007)
  • 著者名/発表者名: Ohama T.
  • 雑誌名: Am J Physiol Gastrointest Liver Physiol 292
  • 査読あり
• [雑誌論文] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice.
  • 著者名/発表者名: Nakajima, A., Matsuki, T., Komine, M., Asahina, A., Horai, R., Ishigame, H., Nakae, S., Kakuta, S., Saijo, S., Iwakura, Y.
  • 雑誌名: J. Immunol. (in press)
• [雑誌論文] The mechanism of lipopolysaccharide-induced human immunodeficiency virus type I activation in transgenic mouse macrophages.
  • 著者名/発表者名: Kadoki, M., Choi, B.I., Iwakura, Y.
  • 雑誌名: Int. Immunol. (in press)
• [雑誌論文] Characterization of a variant virus from ascites of subacute granulomatous serositis in interferon-g-deficient C57BL/6 mice persistently infected with murine coronavirus strain JHM.
  • 著者名/発表者名: Taguchi, F., Matsuyama, S., Iwakura, Y., Tagawa, Y., Saegusa, J., Kyuwa, S.
  • 雑誌名: Viral Immunol. (in press)
• [学会発表] C型レクチン活性化を指標とした機能性食品の開発 (2009)
  • 著者名/発表者名: 岩倉洋一郎
  • 学会等名: Bio Japan 2009アカデミックシーズ発表会
  • 発表場所: パシフィコ横浜
  • 年月日: 2009-10-08
• [学会発表] 強直性脊椎炎様関節炎発症におけるC型レクチンの役割 (2009)
  • 著者名/発表者名: 岩倉洋一郎
  • 学会等名: 第98回日本病理学会総会ワークショップ
  • 発表場所: 京都国際会館、京都
  • 年月日: 2009-05-01
• [学会発表] 細菌感染防御におけるIL-17A、およびIL-17Fの役割 (2009)
  • 著者名/発表者名: 岩倉洋一郎
  • 学会等名: 第82回日本細菌学会総会シンポジウム「細菌感染と自然免疫」
  • 発表場所: 名古屋国際会議場
• [学会発表] マウスモデルが示す関節リウマチの発症機構と治療への道 (2009)
  • 著者名/発表者名: 岩倉洋一郎
  • 学会等名: 第53回日本リウマチ学会賞受賞講演、グランドプリンスホテル新高輪
  • 発表場所: 東京
• [学会発表] 発生工学的アプローチによる創薬ターゲットの探索:関節リウマチをモデルとして (2009)
  • 著者名/発表者名: 岩倉洋一郎
  • 学会等名: 第56回日本実験動物学会シンポジウム「発生工学的アプローチによる創薬ターゲットの探索」(大会長:岩倉洋一郎)
  • 発表場所: 大宮ソニックシティー、大宮
• [学会発表] The roles of IL-17A and IL-17F in the immune system. (2009)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: Th17 Cells in Health and Disease, Keystone Symposium, Fairmont Hotel Vancouver
  • 発表場所: British Columbia, Canada
• [学会発表] The roles of C-type lectins in the host defense against fungal infection and development of autoimmunity. (2009)
  • 著者名/発表者名: Yoichiro Iwakura.
  • 学会等名: CREST International Symposium: Acquired Immunity and Glycobiology (Organized by Tsubata)
  • 発表場所: Kazusa Academia Park, Chiba
• [学会発表] The roles of C-type lectins in the host defense against fungal infection (2009)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: Keynote Lecture, 17th Congress of the International Society for Human and Animal Mycology (ISHAM 2009)
  • 発表場所: Keio Plaza Hotel, Tokyo
• [学会発表] The Roles of IL-17A and IL-17F in inflammation and host defense against bacteria. Chair man and speaker, Symposium 1: Molecular Basis of Inflammation and Innate Immunity. (2009)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: The 9th World Congress on Inflammation
  • 発表場所: Tokyo, Keio Plaza Hotel, Tokyo
• [学会発表] The role of DCIR in the development of autoimmune arthritis. (2009)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: RCAI-JSI International Symposium on Immunology 2009
  • 発表場所: Pacifico Yokohama, Yokohama
• [学会発表] The roles of C-type lectins in the host defense against fungal infection (2009)
  • 著者名/発表者名: Shinobu Saijo
  • 学会等名: International Society for Interferon and Cytokine Research
  • 発表場所: Lisbon, Portugal
• [学会発表] The roles of C-type lectins in the host defense against fungal infection (2009)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: ISHAM 2009
  • 発表場所: Tokyo
• [学会発表] The Roles of IL-17A and IL-17F in Inflammation and Host Defense against Bacteria (2009)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: The 9^<th> World Congress on Inflammation
  • 発表場所: Tokyo
• [学会発表] The role of DCIR in the development of autoimmune diseases (2008)
  • 著者名/発表者名: Noriyuki Fujikado
  • 学会等名: Cytokines 2008
  • 発表場所: Montreal
• [学会発表] Differential roles of IL-17A and IL-17F in allergic responses and host defense against mucoepithelial bacterial infection (2008)
  • 著者名/発表者名: Harumichi Ishigame
  • 学会等名: The 8th Awaji. International Forum on Infection am Immunity
  • 発表場所: Hyogo
• [学会発表] A C-type lectin that involved in the host defense against fungi plays an important role in the development of autoimmune arthritis (2008)
  • 著者名/発表者名: Shinobu Saijo
  • 学会等名: 13th congress of the asia pacific league of associations for rheumatology
  • 発表場所: Yokohama
• [学会発表] The roles of C-type lectins in the host defense against infection and homeostasis of the immune system. (2007)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: 第37回日本免疫学会総会・学術集会シンポジウム「Innate immune response and diseases」グランドプリンスホテル新高輪
  • 発表場所: 東京
  • 年月日: 2007-11-20
• [学会発表] 関節炎における骨破壊メカニズム (2007)
  • 著者名/発表者名: 岩倉洋一郎
  • 学会等名: 第22回日本整形外科学会基礎学術集会
  • 発表場所: 浜松
  • 年月日: 2007-10-25
• [学会発表] 自然免疫認識受容体遺伝子欠損マウスの作製と解析 (2007)
  • 著者名/発表者名: 角田茂
  • 学会等名: 第2回核酸・核タンパク機能性研究会学術集会
  • 発表場所: 恵庭
  • 年月日: 2007-08-10
• [学会発表] Roles of C-type lectins in immune responses. (2007)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: BMB2007 (第30回日本分子生物学会、第80回日本生化学会)
  • 発表場所: 横浜
• [学会発表] Dectin-1の生体防御機構における役割 (2007)
  • 著者名/発表者名: 西城忍
  • 学会等名: 第51回日本医真菌学会総会、ホテルアソシア高山リゾート
  • 発表場所: 岐阜
• [学会発表] Expression of CXCR4 in T cells is crucial for the development of collagen-induced arthritis. (2007)
  • 著者名/発表者名: Soo-hyun Chung
  • 学会等名: The 14th East Asia Joint Symposium on Biomedical Research
  • 発表場所: Tokyo
• [学会発表] The roles of interleukin (IL)-17A and IL-17F in the development of inflammatory responses. (2007)
  • 著者名/発表者名: Harumichi Ishigame
  • 学会等名: The 15th Annual Meeting of the International Cytokine Society
  • 発表場所: San Francisco
• [学会発表] The roles of interleukin (IL)-17A and IL-17F in the development of inflammatory responses. (2007)
  • 著者名/発表者名: Harumichi Ishigame
  • 学会等名: The 13th International Congress of Immunology
  • 発表場所: Rio deJaneiro
• [学会発表] Dectin-1 plays asn important role in host defense against the pathogenic fungus Pneumocvstis carinii. (2007)
  • 著者名/発表者名: Shinobu Saijo
  • 学会等名: The 13th International Congress of Immunology
  • 発表場所: Rio deJaneiro
• [学会発表] Identification of dendritic cell immunoreceptor as a novel arthritis-related gene by transcriptome analysis of rheumatoid arthritis model mice. (2007)
  • 著者名/発表者名: Noriyuki Fujikado
  • 学会等名: The 13th International Congress of Immunology
  • 発表場所: Rio deJaneiro
• [学会発表] Roles of C-type lectins in immune responses. (2007)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: BMB2007(第30回日本分子生物学会、第80回日本生化学会)
  • 発表場所: 横浜
• [学会発表] The roles of C-type lectins in the host defense against infection and homeostasis of the immune system (2007)
  • 著者名/発表者名: Yoichiro Iwakura
  • 学会等名: 第37回日本免疫学会総会・学術集会
  • 発表場所: 品川
• [学会発表] Differential requirement of IL-17A and IL-17F in inflammatory responses and host defense against bacteria (2007)
  • 著者名/発表者名: Harumichi Ishigame
  • 学会等名: 第37回日本免疫学会総会・学術集会
  • 発表場所: 品川
• [学会発表] Dendritic cell immunoreceptor deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells (2007)
  • 著者名/発表者名: Noriyuki Fujikado
  • 学会等名: 第37回日本免疫学会総会・学術集会
  • 発表場所: 品川
• [学会発表] A C-type lectin that involved in host defense against fungi plays an important role in the development of arthritis (2007)
  • 著者名/発表者名: Shinobu Saijo
  • 学会等名: 第37回日本免疫学会総会・学術集会
  • 発表場所: 品川
• [学会発表] Dectin-1の生体防御機構における役割 (2007)
  • 著者名/発表者名: 西城忍
  • 学会等名: 第51回日本医真菌学会総会
  • 発表場所: 高山
• [図書] nterleukin-1 deficiency and aggressiveness in male mice.(M.T. Czerbnska ed., Psychoneuroendocrinology Research Trends) (2007)
  • 著者名/発表者名: Tamagawa, A., Kolosova, I., Endo, Y., Gerlinskaya, L., Iwakura, Y., Moshikin, M.
  • 出版者: Nova Science Publishers, Inc.
• [図書] The roles of IL-17A and IL-17F in mucosal infection and allergy.(ed. S. Jiang, Th17 cells in health and disease)
  • 著者名/発表者名: Ishigame, H., Nakae, S., Iwakura, Y.
  • 出版者: Springer Science + Buisiness(in press)
• [備考] ホームページ等
  • URL: http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html
• [備考]
  • URL: http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html
• [産業財産権] IL-17A/IL-17Fを介した大腸がん発症抑制 (2010)
  • 発明者名: 岩倉洋一郎、角田茂、鈴木俊佐
  • 権利者名: 国立大学法人東京大学
  • 出願年月日: 2010-02-03
  • 取得年月日: 2010-02-03
• [産業財産権] 骨免疫疾患の予防・治療剤 (2010)
  • 発明者名: 岩倉洋一郎、藤門範行、馬光宇
  • 権利者名: 国立大学法人東京大学
  • 出願年月日: 2010-02-23
  • 取得年月日: 2010-02-23
• [産業財産権] IL-17A/IL-17F制御による感染症治療・予防薬Differential Roles of Interleukin-17A and Interleukin-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses (2009)
  • 発明者名: 岩倉洋一郎、角田茂、石亀晴道
  • 権利者名: 国立大学法人東京大学
  • 出願年月日: 2009-12-28
  • 取得年月日: 2009-12-28
• [産業財産権] IL-1タイプIIレセプター遺伝子の欠損変異体マウス (2009)
  • 発明者名: 岩倉洋一郎、角田茂、棚橋侑子、宝来玲子、畦地里衣、中嶋明子
  • 権利者名: 国立大学法人東京大学
  • 出願年月日: 2009-02-05
  • 取得年月日: 2009-02-05
• [産業財産権] IL-17A/IL-17F制御によるアレルギーや細菌感染の治療法の開発Differential Roles of Interleukin-17A and Interleukin-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses (2008)
  • 発明者名: 岩倉洋一郎、角田茂、石亀晴道
  • 権利者名: 国立大学法人東京大学
  • 出願年月日: 2008-12-30
  • 取得年月日: 2008-12-30