抗リン脂質抗体症候群;病因の解明と新たなる治療ターゲット

• 研究課題/領域番号: 19390269
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 膠原病・アレルギー・感染症内科学
• 研究機関: 北海道大学
• 研究代表者: 小池 隆夫 北海道大学, 大学院・医学研究科, 教授 (80146795)
• 研究期間 (年度): 2007 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2008年度: 8,450千円 (直接経費: 6,500千円、間接経費: 1,950千円); 2007年度: 10,270千円 (直接経費: 7,900千円、間接経費: 2,370千円)
• キーワード: 抗リン脂質抗体症候群 / β_2GPI / 血栓形成 / プロテオーム解析 / シグナル伝達 / p38MAPK / ゲルゾリン / インテグリン / 免疫学 / プロテオーム / バイオテクノロジー

研究概要

代表的な抗リン脂質抗体である抗β2グリコプロテインI抗体(抗β2GPI抗体)の血栓原性を明らかにする目的で、単球やマクロファージ細胞株に抗β2GPI抗体を作用させ、抗β2GPI抗体と結合ないし相互作用する細胞表面分子について、免疫沈降法により共沈させ、ウエスタンブロット法あるいは質量分析法などを用いて同定を試みた。質量分析法で同定された複数の候補細胞質蛋白の中でゲルゾリンがβ2GPIと結合していることがウエスタンブロット法で確認された。ゲルゾリンはインテグリンα5β1と共役し、抗β2GPI抗体による細胞刺激に関与する可能性が示唆された。細胞表面分子のみならず抗β2GPI抗体と結合ないし相互作用する流血中の可溶型分子についても検策した。

研究成果

• [雑誌論文] FCGR3A-158V/F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation (2008)
  • 著者名/発表者名: Nishio M, Endo T, Fujimoto K, Yamamoto S, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T.
  • 雑誌名: Eur J Haematol 82(2) ページ: 143-7
  • 査読あり
• [雑誌論文] Antiprothrombin antibody testing: detection and clinical utility. Semin (2008)
  • 著者名/発表者名: Oku K, Atsumi T, Amengual O, Koike T.
  • 雑誌名: Thromb Hemost 34(4) ページ: 335-339
  • 査読あり
• [雑誌論文] Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases : analysis of 30 cases (2008)
  • 著者名/発表者名: Fukaya S, Yasuda S, Hashimoto T, Oku K, Kataoka H, Horita T, Atsumi T, Koike T.
  • 雑誌名: Rheumatology 47(11) ページ: 1686-1691
  • 査読あり
• [雑誌論文] between disease activity and levels of vascular endothelial growth Discrepancy factor in a patient with POEMS syndrome successfully treated with autologous stem-cell transplantation (2008)
  • 著者名/発表者名: Goto H, Nishio M, Kumano K, Fujimoto K, Yamaguchi K, Koike T.
  • 雑誌名: Bone Marrow Transplant 42(9) ページ: 627-629
  • 査読あり
• [雑誌論文] A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia/lymphoma(ATL) : clinical impact of graft-versus-leukemia/lymphoma effect (2008)
  • 著者名/発表者名: Shiratori S, Yasumoto A, Tanaka J, Shigematsu A, Yamamoto S, Nishio M, Hashino S, Morita R, Takahata M, Onozawa M, Kahata K, Kondo T, Ota S, Wakasa K, Sugita J, Koike T, Asaka M, Kasai M, Imamura M.
  • 雑誌名: Biol Blood Marrow Transplant 14 ページ: 817-823
  • NAID: 120005906874
  • 査読あり
• [雑誌論文] Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain (2008)
  • 著者名/発表者名: Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, Hatakeyama S.
  • 雑誌名: Biochim Biophys Acta 1783(5) ページ: 826-837
  • 査読あり
• [雑誌論文] Etiopathology of the Antiphosphospholipid syndrome, In : Tanaka K, Davie EW, editor (2008)
  • 著者名/発表者名: Atsumi T, Amengual O, Koike T.
  • 雑誌名: Recent Advances in Thrombosis and Haemostasis 2008 ページ: 521-535
  • 査読あり
• [雑誌論文] Excellent outcome of allogeneic hematopoietic stem cell transplantation using a conditioning regimen with medium-dose VP-16, cyclophosphamide and total-body irradiation for adult patients with acute lymphoblastic leukemia (2008)
  • 著者名/発表者名: Shigematsu A, Kondo T, Yamamoto S, Sugita J, Onozawa M, Kahata K, Endo T, Shiratori S, Ota S, Shigematsu A, Kondo T, Yamamoto S, Sugita J, Onozawa M, Kahata K, Endo T, Shiratori S, Ota S, Obara M, Wakasa K, Takahata M, Takeda Y, Tanaka J, Hashino S, Nishio M, Koike T, Asaka M, Imamura M.
  • 雑誌名: Biol Blood Marrow Transplant 14(5) ページ: 568-575
  • NAID: 120005906865
  • 査読あり
• [雑誌論文] Exchange of information in Rheumatology between East and West : From Man'yo-shu to the Future (2008)
  • 著者名/発表者名: Atsumi T, Horita T, Minori T, Koike T
  • 雑誌名: Arthritis Rheum 58(2) ページ: 140-142
  • 査読あり
• [雑誌論文] Thrombotic microangiopathy in patients withphosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome (2008)
  • 著者名/発表者名: Kon Y, Atsumi T, Hagiwara H, Furusaki A, Kataoka H, Horita T, Yasuda S, Amengual O, Koike T.
  • 雑誌名: Clin Exp Rheumatol 26(1) ページ: 129-132
  • 査読あり
• [雑誌論文] The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells (2008)
  • 著者名/発表者名: Okamoto T, Atsumi T, Shimizu C, Yoshioka N, Koike T.
  • 雑誌名: J Atheroscler Thromb 15(1) ページ: 13-19
  • NAID: 10022607656
  • 査読あり
• [雑誌論文] Autoimmune disease after autologous hematopoietic stem cell transplantation (2008)
  • 著者名/発表者名: Bohgaki T, Atsumi T, Koike T.
  • 雑誌名: Autoimmun Rev 7(3) ページ: 198-203
  • 査読あり
• [雑誌論文] Polymyalgia rheumatica as the manifestation of unclassified aortitis (2008)
  • 著者名/発表者名: Kataoka H, Atsumi T, Hashimoto T, Horita T, Yasuda S, Koike T.
  • 雑誌名: Mod Rheumatol 18(1) ページ: 105-108
  • NAID: 10024149993
  • 査読あり
• [雑誌論文] Reversible cardiomyopathy due to secondary hemochromatosis with multitransfusions for severe aplastic anemia after successful non-myeloablative stem cell transplantation (2008)
  • 著者名/発表者名: Nishio M, Endo T, Nakao S, Sato N, Koike T.
  • 雑誌名: Int J Cardiol 127 ページ: 400-401
  • 査読あり
• [雑誌論文] Autoimmune disease after autologous hematopoietic stem cell transplantation (2008)
  • 著者名/発表者名: Bohgaki T, Atsumi T, Koike T
  • 雑誌名: Autoimmun Rev 7(3) ページ: 198-203
  • 査読あり
• [雑誌論文] Thrombotic microangiopathy in patients with phosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome (2008)
  • 著者名/発表者名: Kon Y, Atsumi T, Hagiwara H, Furusaki A, Kataoka H, Horita T, Yasuda S, Amengua I O, Koike T
  • 雑誌名: Clin Exp Rheumatol 26(1) ページ: 129-132
  • 査読あり
• [雑誌論文] Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases : analysis of 30 cases (2008)
  • 著者名/発表者名: Fukaya S, Yasuda S, Hashimoto T, Oku K, Kataoka H, Horita T, Atsumi T, Koike T
  • 雑誌名: Rheumatology. 47(11) ページ: 1686-1691
  • 査読あり
• [雑誌論文] Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain (2008)
  • 著者名/発表者名: Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, Hatakevama S.
  • 雑誌名: Biochim Biophys Acta. 1783(5) ページ: 826-837
  • 査読あり
• [雑誌論文] Antiprothrombin antibody testing : detection and clinical utility (2008)
  • 著者名/発表者名: Oku K, Atsumi T, Amengual O. Koike T
  • 雑誌名: Semin Thromb Hemost. 34(4) ページ: 335-339
  • 査読あり
• [雑誌論文] FCGR3A-158V / F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation (2008)
  • 著者名/発表者名: Nishio M, Endo T, Fujimoto K, Yamamoto S, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T
  • 雑誌名: Eur J Haematol 82(2) ページ: 143-147
  • 査読あり
• [雑誌論文] Discrepancy between disease activity and levels of vascular endothelial growth factor in a patient with POEMS syndrome successfully treated with autoloaous stem-cell transplantation (2008)
  • 著者名/発表者名: Goto H, Nishio M, Kumano K, Fujimoto K, Yamaguchi K, Koike T.
  • 雑誌名: Bone Marrow Transplant 42(9) ページ: 627-629
  • 査読あり
• [雑誌論文] A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia / lymphoma (ATL) : clinical impact of graft-versus-leukemia / lymphoma effect (2008)
  • 著者名/発表者名: Shiratori S, Yasumoto A, Tanaka J, Shigematsu A, Yamamoto S, Nishio M, Hashino S, Morita R, Takahata M, Onozawa M, Kahata K, Kondo T, Ota S, Wakasa K, Sugita J, Koike T, Asaka M, Kasai M, Imamura M.
  • 雑誌名: Biol Blood Marrow Transplant. 14 ページ: 817-823
  • NAID: 120005906874
  • 査読あり
• [雑誌論文] Excellent outcome of allogeneic hematopoietic stem cell transplantation using a conditioning regimen with medium-dose VP-16, cyclophosphamide and total-body irradiation for adult patients with acute lymphoblastic leukemia (2008)
  • 著者名/発表者名: Shigematsu A, Kondo T, Yamamoto S, Sugita J, Onozawa M, Kahata K, Endo T, Shiratori S, Ota S, Obara M, Wakasa K, Takahata M, Takeda Y, Tanaka J, Hashino S, Nishio M, Koike T, Asaka M, Imamura M.
  • 雑誌名: Biol Blood Marrow Transplant 14(5) ページ: 568-575
  • NAID: 120005906865
  • 査読あり
• [雑誌論文] The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells (2008)
  • 著者名/発表者名: Okamoto T, Atsumi T, Shimizu C, Yoshioka N, Koike T
  • 雑誌名: J Atheroscler Thromb 15(1) ページ: 13-19
  • NAID: 10022607656
  • 査読あり
• [雑誌論文] Reversible cardiomyopathy due to secondary hemochromatosis with multitransfusions for severe aplastic anemia after successful non-myeloablative stem cell transplantation. (2008)
  • 著者名/発表者名: Nishio M, Endo T, Nakao S, Sato N, Koike T.
  • 雑誌名: Int J Cardiol (in press)
  • 査読あり
• [雑誌論文] Multiple autoimmune diseases after autologous stem-cell transplantation (2007)
  • 著者名/発表者名: Bohgaki T, Atsumi T, Koike T.
  • 雑誌名: New Engl J Med 357(26) ページ: 2734-2736
  • NAID: 120005906870
  • 査読あり
• [雑誌論文] Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis (2007)
  • 著者名/発表者名: Chida D, Nakagawa S, Nagai S, Sagara H, Katsumata H, Imaki T, Suzuki H, Mitani F, Ogishima T, Shimizu C, Kotaki H, Kakuta S, Sudo K, Koike T, Kubo M, Iwakura Y.
  • 雑誌名: PNAS 104(46) ページ: 18205-18210
  • 査読あり
• [雑誌論文] Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26.CID (2007)
  • 著者名/発表者名: Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M, Yamamoto M, Takata N, Kimura A, Koike T, Gejyo F, Matsushita S, Shirasaka T, Kimura S, Oka S.
  • 雑誌名: 45(9) ページ: 1230-1237
  • 査読あり
• [雑誌論文] Soluble fibrin monomer degradation products as a potentially useful marker for hypercoagulable states with accelerated fibrinolysis (2007)
  • 著者名/発表者名: Ieko M, Nakabayashi T, Tarumi T, Naito S, Yoshida M, Kanazawa K, Mizukami K, Koike T.
  • 雑誌名: Clin Chim Acta 386(1-2) ページ: 38-45
  • 査読あり
• [雑誌論文] Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus (2007)
  • 著者名/発表者名: Yasuda S, Stevens RL, Terada T, Takeda M, Hashimoto T, Fukae J, Horita T, Kataoka H, Atsumi T, Koike T.
  • 雑誌名: J. Immunol 179(7) ページ: 4890-4900
  • 査読あり
• [雑誌論文] The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation (2007)
  • 著者名/発表者名: Atsumi T, Cho YR, Leng L, McDonald C, Yu T, Danton C, Hong EG, Mitchell RA, Metz C, Niwa H, Takeuchi J, Onodera S, Umino T, Yoshioka N, Koike T, Kim JK, Bucala R.
  • 雑誌名: Immunol 179(8) ページ: 5399-5406
  • 査読あり
• [雑誌論文] Increased fructose 2, 6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes (2007)
  • 著者名/発表者名: Atsumi T, Chiba H, Yoshioka N, Bucala R, Koike T.
  • 雑誌名: Endocr J 57(4) ページ: 517-520
  • NAID: 10019809194
  • 査読あり
• [雑誌論文] Amicrobial pustulosis associated with IgA nephropathy and Sjogren's syndrome (2007)
  • 著者名/発表者名: Natsuga K, Sawamura D, Homma E, Nomura T, Abe M, Muramatsu R, Mochizuki T, Koike T, Shimizu H.
  • 雑誌名: J Am Acad Dermatol 57 ページ: 523-526
  • 査読あり
• [雑誌論文] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies (2007)
  • 著者名/発表者名: Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T.
  • 雑誌名: Lupus 16(7) ページ: 509-516
  • 査読あり
• [雑誌論文] A polymorphism in human platelet antigen 6b and risk of thrombocytopenia in patients with systemic lupus erythematosus (2007)
  • 著者名/発表者名: Amengual O, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, Koike T.
  • 雑誌名: Arthritis Rheum. 56(8) ページ: 2803-2809
  • 査読あり
• [雑誌論文] Acute onset of type 1 diabetes accompanied by acute hepatitis C : the potential role of proinflammatory cytokine in the pathogenesis of autoimmune diabetes (2007)
  • 著者名/発表者名: Masuda H, Atsumi T, Fujisaku A, Shimizu C, Yoshioka N, Koike T.
  • 雑誌名: Diabetes Res Clin Pract 75(3) ページ: 357-361
  • 査読あり
• [雑誌論文] Delayed redistribution of CD27, CD40 and CD80 positive B cells and the impaired in vitro immunoglobulin production in patients with non-Hodgkin lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation (2007)
  • 著者名/発表者名: Nishio M, Fujimoto K, Yamamoto S, Endo T, Sakai T, Obara M, Kumano K, Yamaguchi K, Takeda Y, Goto H, Sato N, Koizumi K, Mukai M, Koike T.
  • 雑誌名: Br J Haematol 137(4) ページ: 349-354
  • 査読あり
• [雑誌論文] Hepatosplenic alpha/beta T cell lymphoma presenting with cold agglutinin disease (2007)
  • 著者名/発表者名: Minauchi K, Nishio M, Itoh T, Yamamoto S, Fujimoto K, Sato N, Koike T.
  • 雑誌名: Ann Hematol 86(2) ページ: 155-157
  • NAID: 120000973066
  • 査読あり
• [雑誌論文] Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome (2007)
  • 著者名/発表者名: Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano H, Koike T.
  • 雑誌名: J Endocrinol Invest 30 ページ: 65-69
  • 査読あり
• [雑誌論文] "Resurrection of thrombin" in the pathophysiology of the antiphospholipid syndrome (2007)
  • 著者名/発表者名: Koike T, Atsumi T.
  • 雑誌名: Arthritis Rheum 56(2) ページ: 393-394
  • 査読あり
• [雑誌論文] Polymyalgia rheumatica as the manifestation of unclassified aortits. (2007)
  • 著者名/発表者名: Kataoka H, Atsumi T, Hashimoto T, Horita T, Yasuda S, Koike T.
  • 雑誌名: Mod Rheumatol 18(1) ページ: 105-108
  • 査読あり
• [雑誌論文] Multiple autoimmune diseases after autologous stem-cell transplantation. (2007)
  • 著者名/発表者名: Bohgaki T, Atsumi T, Koike T.
  • 雑誌名: New Engl J Med. 357(26) ページ: 2734-2736
  • NAID: 120005906870
  • 査読あり
• [雑誌論文] Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. (2007)
  • 著者名/発表者名: Chida D, Nakagawa S, Nagai S, Sagara H, Katsumata H, Imaki T, Suzuki H, Mitani F, Ogishima T, Shimizu C, Kotaki H, Kakuta S, Sudo K, Koike T, Kubo M, Iwakura Y.
  • 雑誌名: PNAS. 104(46) ページ: 18205-18210
  • 査読あり
• [雑誌論文] Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26. (2007)
  • 著者名/発表者名: Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M, Yamamoto M, Takata N, Kimura A, Koike T, Gejyo F, Matsushita S, Shrasaka T, Kimura S, Oka S.
  • 雑誌名: CID 45(9) ページ: 1230-1237
  • 査読あり
• [雑誌論文] Soluble fibrin monomer degradation products as a potentially useful markerfor hypercoagulable states with accelerated fibrinolysis. (2007)
  • 著者名/発表者名: eko M, Nakabayashi T, Tarumi T, Naito S, Yoshida M, Kanazawa K, Mizukami K, Koike T.
  • 雑誌名: Clin Chim Acta. 386(1-2) ページ: 38-45
  • 査読あり
• [雑誌論文] Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. (2007)
  • 著者名/発表者名: Yasuda S, Stevens RL, Terada T, Takeda M, Hashimoto T, Fukae J, Horita T, Kataoka H, Atsumi T, Koike T.
  • 雑誌名: J. Immunol 179(7) ページ: 4890-4900
  • 査読あり
• [雑誌論文] The Proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. (2007)
  • 著者名/発表者名: Atsumi T, Cho YR, Leng L, McDonald C, Yu T, Danton C, Hong EG, Mitchell RA, Metz C, Niwa H, Takeuchi J, Onodera S, Umino T, Yoshioka N, Koike T, Kim JK, Bucala R.
  • 雑誌名: J. Immunol 179(8)
  • 査読あり
• [雑誌論文] Increased fructose 2, 6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes. (2007)
  • 著者名/発表者名: Atsumi T, Chiba H, Yoshioka N, Bucala R, Koike T.
  • 雑誌名: Endocr J. 57(4) ページ: 517-520
  • NAID: 10019809194
  • 査読あり
• [雑誌論文] Amicrobial pustulosis associated with IgA nephropathy and Sjogren's syndrome. (2007)
  • 著者名/発表者名: Natsuga K, Sawamura D, Homma E, Nomura T, Abe M, Muramatsu R, Mochizuki T, Koike T, Shimizu H.
  • 雑誌名: J Am Acad Dermatol 57 ページ: 523-526
  • 査読あり
• [雑誌論文] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies. (2007)
  • 著者名/発表者名: Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T.
  • 雑誌名: Lupus. 16(7) ページ: 509-516
  • 査読あり
• [雑誌論文] A polymorphism in human platelet antigen 6b and risk of thrombocytopenia in patients with systemic lupus erythematosus. (2007)
  • 著者名/発表者名: Amengual O, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, KoikeT.
  • 雑誌名: Arthritis Rheum. 56(8) ページ: 2803-2809
  • 査読あり
• [雑誌論文] Acute onset of type 1 diabetes accompanied by acute hepatitis C: the potential role of proinflammatory cytokine in the pathogenesis of autoimmune diabetes. (2007)
  • 著者名/発表者名: Masuda H, Atsumi T, Fujisaku A, Shimizu C, Yoshioka N, Koike T.
  • 雑誌名: Diabetes Res Clin Pract 75(3) ページ: 357-361
  • 査読あり
• [雑誌論文] Delayed redistribution of CD27, CD40 and CD80 positive B cells and the impaired in vitro immunoglobulin production in patients with non-Hodgkinlymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation. (2007)
  • 著者名/発表者名: Nishio M, Fujimoto K, Yamamoto S, Endo T, Sakai T, Obara M, Kumano K, Yamaguchi K, Takeda Y, Goto H, Sato N, Koizumi K, Mukai M, Koike T.
  • 雑誌名: Br J Haematol 137(4) ページ: 349-354
  • 査読あり
• [雑誌論文] Hepatosplenic alpha/beta T cell lymphoma presenting with cold agglutinin disease. (2007)
  • 著者名/発表者名: Minauchi K, Nishio M, Itoh T, Yamamoto S, Fujimoto K, Sato N, Koike T.
  • 雑誌名: Ann Hematol. 86(2) ページ: 155-157
  • NAID: 120000973066
  • 査読あり
• [雑誌論文] Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome. (2007)
  • 著者名/発表者名: Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano H, Koike T.
  • 雑誌名: J Endocrinol Invest 30 ページ: 65-69
  • 査読あり
• [雑誌論文] "Resurrection of thrombin" in the pathophysiology of the antiphospholipid syndrome. (2007)
  • 著者名/発表者名: Koike T, Atsumi T.
  • 雑誌名: Arthritis Rheum 56(2) ページ: 393-394
  • 査読あり
• [雑誌論文] STAT4single nucleotide polymorphism,rs7574865 G/T,as a risk for antiphospholipid syndrome
  • 著者名/発表者名: Horita T, Atsumi T, Yoshida N, Nakagawa H, Kataoka H, Yasuda S, Koike T.
  • 雑誌名: Ann Rheum Dis (in press)
  • 査読あり
• [雑誌論文] Complement activation in patients with primary antiphospholipid syndrome
  • 著者名/発表者名: Oku K, Atsumi T, Bohgaki M, Amengual O, Kataoka H, Horita T, Yasuda S, Koike T.
  • 雑誌名: Ann Rheum Dis (in press)
  • 査読あり
• [雑誌論文] Complement activation in patients with primary antiphospholipid syndrome
  • 著者名/発表者名: Oku K, Atsumi T, Bohgaki M, Kataoka H, Horita T, Yasuda S, Koike T.
  • 雑誌名: Ann Rheum Dis (In press)
  • 査読あり
• [雑誌論文] STAT4 single nucleotide polymorphism, rs7574865 G /T, as a risk for antiphospholipid syndrome
  • 著者名/発表者名: Horita T, Atsumi T, Yoshida N, Nakagawa H, Kataoka H, Yasuda S. Koike T.
  • 雑誌名: Ann Rheum Dis (In press)
  • 査読あり
• [雑誌論文] Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis : relationship between clinical benefits and intensity of immunosuppression
  • 著者名/発表者名: Bohgaki T, Atsumi T, Bohgaki M, Furusaki A, Kondo M, Sato-MatsumuraK, Abe R, Kataoka H, Horita T, Yasuda S, Amasaki Y, Nishio M, Sawada K, Shimizu H, Koike T.
  • 雑誌名: J Rheumatol (In press)
  • 査読あり
• [学会発表] Development of Autoimmune Diseases : A Lesson from Stem Cell Transplantation (2008)
  • 著者名/発表者名: Koike, T
  • 学会等名: 6^<th> International Congress on Autoimmunity, Porto, Portugal
  • 発表場所: Porto, Portugal
  • 年月日: 2008-09-13
• [学会発表] Development of Autoimmune Diseases : A Lesson from Stem Cell Transplantation (2008)
  • 著者名/発表者名: Koike, T
  • 学会等名: 6^<th> International Congress on Autoimmunity
  • 発表場所: コングレスセンター, Porto, Portugal
  • 年月日: 2008-09-13
• [学会発表] Multiple autoimmune diseases after CD34+- selected autologous hematopoietic stem cell transplantation in a patient with systemic sclerosis (2008)
  • 著者名/発表者名: Koike, T
  • 学会等名: The Mosaic of Autoimmunity
  • 発表場所: Kfar Maccabiah, Israel
  • 年月日: 2008-02-11
• [学会発表] Multiple autoimmune diseases after CD34+ selected autologous hematopoietic stem cell transplantation in a patient with systemic sclerosis (2008)
  • 著者名/発表者名: Koike, T. :
  • 学会等名: The Mosaic of Autoimmunity
  • 発表場所: Kfar Maccabiah Olympic Village, Israel,
  • 年月日: 2008-02-11
• [学会発表] Antiphospholipid antibodies and cell acyivation (2007)
  • 著者名/発表者名: Koike,T
  • 学会等名: 12^<th> International Congress on Antiphospholipid Antibodies
  • 発表場所: Florence, Italy
  • 年月日: 2007-04-18
• [学会発表] Antiphospholipid antibodies and cell acyivation (2007)
  • 著者名/発表者名: Koike, T.
  • 学会等名: 12th International Congress on Antiphospholipid Antibodies
  • 発表場所: Palazzo dei Congressi, Florence, Italy
  • 年月日: 2007-04-18
• [学会発表] Recent Progress in Systemic Autommune Diseases (2007)
  • 著者名/発表者名: Koike,T
  • 学会等名: 第8回国際SLE学会
  • 発表場所: 上海
• [学会発表] Recent Progress in Systemic Autommune Diseases (2007)
  • 著者名/発表者名: Koike, T
  • 学会等名: 第8回国際SLE学会
  • 発表場所: Shanghai international Convention Center, 上海
• [図書] Recent Advances in Thrombosis and Haemostasis 2008 (2008)
  • 著者名/発表者名: Atsumi T, Amengual O, Koike T
  • 総ページ数: 643
  • 出版者: Springer