樹状細胞を介した統合的免疫制御によるC型肝炎・肝癌治療法の開発

• 研究課題/領域番号: 19590765
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 消化器内科学
• 研究機関: 大阪大学
• 研究代表者: 考藤 達哉 大阪大学, 医学系研究科, 寄附講座准教授 (80372613)
• 研究分担者: 竹原 徹郎 大阪大学, 医学系研究科, 准教授 (70335355) ; 平松 直樹 大阪大学, 医学系研究科, 講師 (30362700)
• 研究期間 (年度): 2007 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2009年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円); 2008年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円); 2007年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
• キーワード: 樹状細胞 / C型肝炎 / Toll様受容体 / インターフェロンα / リバビリン / HCVプロテアーゼ阻害剤 / Type III IFN / RIG-I

研究概要

C型肝炎の病態には、樹状細胞(DC)の機能低下が関与している。本研究では、C型慢性肝炎患者のミエロイドDC(MDC)ではTLR刺激によるインターフェロン(IFN)の産生能が低下していること、それにはTRIF、TRAF6の発現低下が関与することを明らかにした。HCV NS3/4A阻害剤によって、MDCのIFN産生能やT細胞刺激能も回復することから、MDCが抗HCVの治療標的となる可能性が示された。

研究成果

• [雑誌論文] (2010)
  • 著者名/発表者名: Nalesnik MA, Kanto T
  • 雑誌名: Natural killer cells and hepatitis C virus infection. Lotze MT and Thompson AW eds Natural killer cells : Basic science and clinical application(Elsevier London) ページ: 571-587
• [雑誌論文] Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin: reducing drug doses has no impact on rapid and susutained virological responses. (2009)
  • 著者名/発表者名: Inoue, Y., Hiramatsu, N, Oze, T., Yakushijin, T., Mochizuki, K., Hagiwara, H., Oshita, M., Mita, E., Fukui, H., Inada, M., Tamura, S., Yoshihara, H., Hyashi, E., Inoue, A., Imai, Y., Kato, M., Miyagi, T., Hohsui, A., Ishida, M., Kiso, S., Kanto, T., Kasahara, A., Takehara, T., Hayashi, N.
  • 雑誌名: Journal of Viral Hepatitis (in press)
  • 査読あり
• [雑誌論文] Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis. (2009)
  • 著者名/発表者名: Itose, I., Kanto, T. Kakita, N., Takebe, S., Inoue, M., Higashitani, K., Miyazaki, M., Miyatake, H., Sakakibara, M., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • 雑誌名: Journal of Viral Hepatitis 16 ページ: 846-852
  • 査読あり
• [雑誌論文] Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. (2009)
  • 著者名/発表者名: Kohga, K., Takehara, T. Tatsumi, T., Miyagi, T., Ishida, H., Ohkawa, K., Kanto, T., Hiramatsu, N., Hayashi, N.
  • 雑誌名: Cancer Resarch 69 ページ: 8050-8057
  • 査読あり
• [雑誌論文] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver. (2009)
  • 著者名/発表者名: Hikita H, Takehara T., Shimizu, S., Kodama, T., Li, W., Miyagi, T., Hosui, A., Ishida, H., Ohkawa, K., Kanto, T., Hiramatsu, N., Yin, X.M., Hennighausen, L., Tatsumi, T., Hayashi, N.
  • 雑誌名: Hepatology 16 ページ: 1217-1226
  • 査読あり
• [雑誌論文] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin. (2009)
  • 著者名/発表者名: Hiramatsu, N., Oze, T Yakushijin, T., Inoue, Y., Igura, T., Mochizuki, K., Imanaka, K., Kaneko, A., Oshita, M., Hagiwara, H., Mita, E., Nagase, T., Ito, T., Inui, Y., Hijioka, T., Katayama, K., Tamura, S., Yoshihara, H., Imai, Y., Kato, M., Yoshida, Y., Tatsumi, T., Ohkawa, K., Kiso, S., Kanto, T., Kasahara, A., Takehara, T., Hayashi, N.
  • 雑誌名: Journal of Viral Hepatitis 16 ページ: 586-594
  • 査読あり
• [雑誌論文] Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir (2009)
  • 著者名/発表者名: Kurashige N., Ohkawa, K Hiramatsu, N., Oze, T., Yakushijin, T., Mochizuki, K., Hosui, A., Miyagi, T., Ishida, H., Tatsumi, T., Kanto, T., Takehara, T., Hayashi, N.
  • 雑誌名: Antiviral Therapy 14 ページ: 873-877
  • 査読あり
• [雑誌論文] Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis (2009)
  • 著者名/発表者名: Itose, I., Kanto, T., et al.
  • 雑誌名: Journal of Viral Hepatitis 16 ページ: 846-852
  • 査読あり
• [雑誌論文] Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma (2009)
  • 著者名/発表者名: Kohga, K., Takehara, T., et al.
  • 雑誌名: Cancer Resarch 69 ページ: 8050-8057
  • 査読あり
• [雑誌論文] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver (2009)
  • 著者名/発表者名: Hikita H, Takehara T., et al.
  • 雑誌名: Hepatology 50 ページ: 1217-1226
  • 査読あり
• [雑誌論文] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin (2009)
  • 著者名/発表者名: Hiramatsu, N., Oze, T, et al.
  • 雑誌名: Journal of Viral Hepatitis 16 ページ: 586-594
  • 査読あり
• [雑誌論文] Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir (2009)
  • 著者名/発表者名: Kurashige N., Ohkawa, K, et al.
  • 雑誌名: Antiviral Therapy 14 ページ: 873-877
  • 査読あり
• [雑誌論文] Virus associated innate immunity in liver. (2008)
  • 著者名/発表者名: Kanto T.
  • 雑誌名: Frontiers in Bioscience 13 ページ: 6183-6192
  • 査読あり
• [雑誌論文] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virusinfection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I (2008)
  • 著者名/発表者名: Miyazaki M., Kanto T., Inoue, M., Itose, I., Miyatake, H., Sakakibara, M., Yakushijin, T., Kakita, N., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • 雑誌名: Journal of Medical Virology 80 ページ: 980-988
  • 査読あり
• [雑誌論文] Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma. (2008)
  • 著者名/発表者名: Kohga K., Takehara T., Tatsumi, T., Ohkawa, K., Miyagi, T., Hiramatsu, N., Kanto, T., Kasugai, T., Katayama, K., Kato, M., Hayashi, N.
  • 雑誌名: Cancer Science 99 ページ: 1643-1649
  • NAID: 10024010054
  • 査読あり
• [雑誌論文] A new prognostic system for hepatocellular carcinoma including recurrent cases: a study of 861 patients in a single institution. (2008)
  • 著者名/発表者名: Toyama T., Hiramatsu N. Yakushijin, T., Oze, T., Nakanishi, F., Yasumaru, M., Mochizuki, K., Kanto, T., Takehara, T., Kasahara, A., Hayashi, N.
  • 雑誌名: Journal of Clinical Gastroenterology 42 ページ: 317-322
  • 査読あり
• [雑誌論文] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine. (2008)
  • 著者名/発表者名: Kurashige N., Hiramatsu N. Ohkawa, K., Oze, T., Inoue, Y., Kurokawa, M., Yakushijin, T., Igura, T., Kiso, S., Kanto, T., Takehara, T., Tamura, S., Kasahara, A., Oshita, M., Hijioka, T., Katayama, K., Yoshihara, H., Hayashi, E., Imai, Y., Kato, M., Hayashi, N.
  • 雑誌名: Hepatology Research 38 ページ: 450-456
  • NAID: 10024148320
  • 査読あり
• [雑誌論文] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I (2008)
  • 著者名/発表者名: Miyazaki M., Kanto T., et al.
  • 雑誌名: Journal of Medical Virology 80 ページ: 980-988
  • 査読あり
• [雑誌論文] Serum levels of soluble major histocompatibility complex (MHC)class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma. (2008)
  • 著者名/発表者名: Kohga K., Takehara T., et al.
  • 雑誌名: Cancer Science 99 ページ: 1643-1649
  • NAID: 10024010054
  • 査読あり
• [雑誌論文] Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus. (2008)
  • 著者名/発表者名: Ohkawa K., Takehara T., et al.
  • 雑誌名: Journal of Infectious Diseases 198 ページ: 1150-1158
  • 査読あり
• [雑誌論文] A new prognostic system for hepatocellular carcinoma including recurrent cases : a study of 861 patients in a single institution. (2008)
  • 著者名/発表者名: Toyama T., Hiramatsu N., et al.
  • 雑誌名: Journal of Clinical Gastroenterology 42 ページ: 317-322
  • 査読あり
• [雑誌論文] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine. (2008)
  • 著者名/発表者名: Kurashige N., Hiramatsu N., et al.
  • 雑誌名: Hepatology Research 38 ページ: 450-456
  • NAID: 10024148320
  • 査読あり
• [雑誌論文] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I (2008)
  • 著者名/発表者名: Miyazaki M., Kanto T., et. al.
  • 雑誌名: Journal of Medical Virology (In press)
  • 査読あり
• [雑誌論文] Impaired ability of interferon-alpha-primed dendritic cells to stimulate Th1-type CD4 T cell response in chronic hepatitis C virus infection. (2007)
  • 著者名/発表者名: Miyatake H., Kanto T., Inoue, M., Sakakibara, M., Kaimori, A., Yakushijin, T., Itose, I., Miyazaki, M., Kuzushita, N., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • 雑誌名: Journal of Viral Hepatitis 14 ページ: 404-412
  • 査読あり
• [雑誌論文] Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C patients. (2007)
  • 著者名/発表者名: Itose I., Kanto T., Inoue, M., Miyazaki, M., Miyatake, H., Sakakibara, M., Yakushijin, T., Oze, T., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • 雑誌名: Journal of Medical Virology 79 ページ: 511-521
  • 査読あり
• [雑誌論文] Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. (2007)
  • 著者名/発表者名: Abe, T., Kaname, Y., Hamamoto, I., Tsuda, Y., Wen, X., Taguwa, S., Moriishi, K., Takeuchi, O., Kawai, T., Kanto, T., Hayashi, N., Akira, S., Matsuura, Y.
  • 雑誌名: Journal of Virology 81 ページ: 8953-8966
  • 査読あり
• [雑誌論文] Innate immunity in hepatitis C virus infection: Interplay amongdendritic cells, natural killer cells and natural killer T cells. (2007)
  • 著者名/発表者名: Kanto, T., Hayashi, N.
  • 雑誌名: Hepatolgy Reseach 37Suppl
  • NAID: 10019796655
  • 査読あり
• [雑誌論文] Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins (2007)
  • 著者名/発表者名: Tani, H., Komoda, Y., Matsuo, E., Suzuki, K., Hamamoto, I., Yamashita, T., Moriishi, K., Fujiyama, K., Kanto, T., Hayashi, N., Owsianka, A., Patel, A.H., Whitt, M.A., Matsuura, Y.
  • 雑誌名: Journal of Virology 81 ページ: 8601-8612
  • 査読あり
• [雑誌論文] Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities (2007)
  • 著者名/発表者名: Jinushi, M., Takehara, T., Tatsumi, T., Yamaguchi, S., Sakamori, R., Hiramatsu, N., Kanto, T., Ohkawa, K., Hayashi, N
  • 雑誌名: Immunology 120 ページ: 73-82
  • 査読あり
• [雑誌論文] Impaired ability of interferon-alpha-primed dendritic cells to stimulate Th1-type CD4 T cell response in chronic hepatitis C virus infection. (2007)
  • 著者名/発表者名: Miyatake H., Kanto T., et. al.
  • 雑誌名: Journal of Viral Hepatitis 14 ページ: 404-412
  • 査読あり
• [雑誌論文] Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C patients. (2007)
  • 著者名/発表者名: Itose I., Kanto T., et. al.
  • 雑誌名: Journal of Medical Virology 79 ページ: 511-521
  • 査読あり
• [雑誌論文] Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. (2007)
  • 著者名/発表者名: Abe, T., Kaname, Y., et. al.
  • 雑誌名: Journal of Virology 81 ページ: 8953-8966
  • 査読あり
• [雑誌論文] Innate immunity in hepatitis C virus infection: Interplay amongdendritic cells, natural killer cells and natural killer T celles. (2007)
  • 著者名/発表者名: Kanto, T. and Hayashi, N.
  • 雑誌名: Hepatolgy Reseach 37Suppl3
  • NAID: 10019796655
  • 査読あり
• [雑誌論文] Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins (2007)
  • 著者名/発表者名: Tani, H., Komoda, Y., et. al.
  • 雑誌名: Journal of Virology 81 ページ: 8601-8612
  • 査読あり
• [雑誌論文] Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities (2007)
  • 著者名/発表者名: Jinushi, M., Takehara, T., et. al.
  • 雑誌名: Immunology 120 ページ: 73-82
  • 査読あり
• [学会発表] Dynamics of plasmacytoid dendritic cells as a predictor of relapse regardless of virological response in pegylated interferon-a and ribavirin therapy in chronic hepatitis C patients. (2009)
  • 著者名/発表者名: Kanto T, et. al.
  • 学会等名: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Feasibility of IL-10-producing regulatory Type 1 cells for the monitoring of viable hepatocellular carcinoma through local ablation therapy. (2009)
  • 著者名/発表者名: Kakita N, Kanto T, et. al.
  • 学会等名: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Myeloid dendritic cells as a therapeutic target for immune restoration by HCV NS3 protease inhibitor in chronic hepatitis C patients (2009)
  • 著者名/発表者名: Miyazaki M, Kanto T, et. al.
  • 学会等名: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Therapeutic virological response restores impaired capacity of myeloid dendritic cells in chronic hepatitis B patients (2009)
  • 著者名/発表者名: Higashitani K, Kanto T, et. al.
  • 学会等名: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Reduced drug doses in genotype 1 patients with chronic hepatitis C during treatment with pegylated interferon alfa-2B plus ribavirin delays the timing of HCVRNA negativity or prevents its attainment; A propensity score-matched study. (2009)
  • 著者名/発表者名: Son C, Hiramatsu N, et. al.
  • 学会等名: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Prediction of early response to pegylated interferon and ribavirin in chronic hepatitis C based on amino acid substitutions in the viral core region. (2009)
  • 著者名/発表者名: Inoue Y, Hiramatsu N, et. al.
  • 学会等名: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Dynamics of plasmacytoid dendritic cells as a predictor of relapse regardless of virological response in pegylated interferon-a and ribavirin therapy in chronic hepatitis C patients (2009)
  • 著者名/発表者名: Kanto T, Itose I, et al.
  • 学会等名: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Feasibility of IL-10-producing regulatory Type 1 cells for the monitoring of viable hepatocellular carcinoma through local ablation therapy (2009)
  • 著者名/発表者名: Kakita N, Kanto T, et al.
  • 学会等名: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Myeloid dendritic cells as a therapeutic target for immune restoration by HCV NS3 protease inhibitor in chronic hepatitis C patients (2009)
  • 著者名/発表者名: Miyazaki M, Kanto T, et al.
  • 学会等名: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Therapeutic virological response restores impaired capacity of myeloid dendritic cells in chronic hepatitis B patients (2009)
  • 著者名/発表者名: Higashitani K, Kanto T, et al
  • 学会等名: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • 発表場所: Boston, MA, USA
• [学会発表] Natural regulatory T cells as biomarker for the assessment of hepatocellular carcinoma in local ablation therapy (2008)
  • 著者名/発表者名: Kakita N., Kanto T., et al
  • 学会等名: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: San Francisco, CA. USA
  • 年月日: 2008-11-03
• [学会発表] Dynamic changes of regulatory T cell subsets in patients with chronic HCV infection in relation to the degree of liver inflammation (2008)
  • 著者名/発表者名: Itose I., Kanto T, et. al.
  • 学会等名: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: San Francisco, CA. USA
  • 年月日: 2008-11-02
• [学会発表] t al IL-7 as a booster of Th2-differentiation by modulating myeloid dendritic cells in chronic hepatitis C virus infection (2008)
  • 著者名/発表者名: Takebe S., Kanto T
  • 学会等名: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: San Francisco, CA. USA
  • 年月日: 2008-11-02
• [学会発表] Natural regulatory T cells as biomarker for the assessment of hepatocellular carcinoma in local ablation therapy (2008)
  • 著者名/発表者名: Kakita N., Kanto T, et. al
  • 学会等名: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: San Francisco, CA. USA
  • 年月日: 2008-11-02
• [学会発表] Dynamic changes of regulatory T cell subsets in patients with chronic HCV infection in relation to the degree of liver inflammation (2008)
  • 著者名/発表者名: Itose I., Kanto T., et al
  • 学会等名: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: San Francisco, CA. USA
  • 年月日: 2008-11-02
• [学会発表] IL-7 as a booster of Th2-differentiation by modulating myeloid dendritic cells in chronic hepatitis C virus infection (2008)
  • 著者名/発表者名: Takebe S., Kanto T., et al
  • 学会等名: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 発表場所: San Francisco, CA. USA
  • 年月日: 2008-11-02
• [学会発表] NK and NKT-dendritic cell interactions in HCV infection (2008)
  • 著者名/発表者名: Kanto T.
  • 学会等名: Hepatic Inflammation and Immunity 2008
  • 発表場所: Galveston, Texas USA
  • 年月日: 2008-01-27
• [学会発表] Dendritic cell as a versatile controller of innate and adaptive immune response against hepatitis C virus (2008)
  • 著者名/発表者名: Kanto T.
  • 学会等名: The 10th International Symposium on Dendritic Cells
  • 発表場所: Kobe, Japan
• [学会発表] Impaired TLR/RIG-I-mediated innate immunity in myeloid dendritic cells in chronic hepatitis C patients (2008)
  • 著者名/発表者名: Miyazaki M. Kanto T, et. al.
  • 学会等名: The 10th International Symposium on Dendritic Cells
  • 発表場所: Kobe, Japan
• [学会発表] Novel mature dendritic cells inducible from monocytes with OK432, PGE1 and IFN-a serve as potent vaccine vehicles for gastrointestinal cancers (2008)
  • 著者名/発表者名: Sakakibara M., Kanto T, et. al.
  • 学会等名: The 10th International Symposium on Dendritic Cells
  • 発表場所: Kobe, Japan
• [学会発表] NK and NKT-dendritic cell interactions in HCV infection Hepatic (2008)
  • 著者名/発表者名: Kanto T.
  • 学会等名: Inflammation and Immunity 2008
  • 発表場所: Galveston, Texas USA
• [学会発表] Dendritic cell as a versatile controller of innate and adaptive immune response against hepatitis C virus (2008)
  • 著者名/発表者名: Kanto T.
  • 学会等名: The 10^<th> International Symposium on Dendritic Cells
  • 発表場所: Kobe, Japan
• [学会発表] Impaired TLR/RIG-I-mediated innate immunity in myeloid dendritic cells in chronic hepatitis C patients (2008)
  • 著者名/発表者名: Miyazaki M., Kanto T, et al.
  • 学会等名: The 10^<th> International Symposium on Dendritic Cells
  • 発表場所: Kobe, Japan
• [学会発表] Novel mature dendritic cells inducible from monocytes with OK432, PGE1 and IFN-a serve as potent vaccine vehicles for gastrointestinal cancers (2008)
  • 著者名/発表者名: Sakakibara M., Kanto T, et al.
  • 学会等名: The 10^<th> International Symposium on Dendritic Cells
  • 発表場所: Kobe, Japan
• [備考] 大阪大学大学院医学系研究科消化器内科学ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm
• [備考]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm
• [備考]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm
• [備考]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm