頚動脈小体と低酸素性化学受容体伝達の遺伝学的個体差について検討

• 研究課題/領域番号: 19591816
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 麻酔・蘇生学
• 研究機関: 獨協医科大学
• 研究代表者: 山口 重樹 獨協医科大学, 医学部, 准教授 (50306198)
• 研究期間 (年度): 2007 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2008年度: 650千円 (直接経費: 500千円、間接経費: 150千円); 2007年度: 4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
• キーワード: 頚動脈小体 / glomus細胞 / 低酸素性呼吸応答 / 遺伝 / イオンチャネル / アセチルコリン受容体 / DBA / 2J / A / J / 発達 / Glial Cell-deliverd neurotrophic fancor

研究概要

近交系マウスを用いて,頚動脈小体の形態学的な遺伝的個体差の存在が明らかになった。さらに,頚動脈小体を構成するglomus細胞におけるneuronal nicotinic acetylcholine receptorsの発現様式における遺伝的個体差を明らかにし,glomus細胞の低酸素性化学伝達の遺伝学的個体差の存在が明らかとなった。これらのことが,低酸素性呼吸応答の遺伝学的個体差の要因になっていると推測した。

研究成果

• [雑誌論文] Measurement of shift of the cauda equina in the subarachnoid space by changing position. Regional (2009)
  • 著者名/発表者名: Takiguchi T, Yamaguchi S, et al.
  • 雑誌名: Anesthesia and Pain Medicine 34 ページ: 0-0
  • 査読あり
• [雑誌論文] Effects of landiolol on QT interva and QT dispersion during tracheal intubation using computerized measurement. (2009)
  • 著者名/発表者名: Kaneko M, Yamaguchi S, et al.
  • 雑誌名: Journal of Clinical Anesthesia 21 ページ: 0-0
  • 査読あり
• [雑誌論文] Assessment of QT interval and QT dispersion during lectroconvulsive therapy using computerized measurements. (2009)
  • 著者名/発表者名: Tezuka N,Yamaguchi S, et al.
  • 雑誌名: Journal of ECT 25(in press) ページ: 0-0
  • 査読あり
• [雑誌論文] Measurement of shift of the cauda equina in the subarachnoid space by changing position (2009)
  • 著者名/発表者名: Takiguchi T, Yamaguchi S, et al.
  • 雑誌名: Regional Anesthesia and Pain Medicine (in press)
  • 査読あり
• [雑誌論文] Effects of landiolol on QT interval and QT dispersion during tracheal intubation using computerized measurement (2009)
  • 著者名/発表者名: Kaneko M, Yamaguchi s, Et al.
  • 雑誌名: Journal of Clinical Anesthesia (in press)
  • 査読あり
• [雑誌論文] Assessment of QT interval and QT dispersion during electroconvulsive therapy using computerized measurements (2009)
  • 著者名/発表者名: Tezuka N, Yamaguchi s, et al.
  • 雑誌名: Journal of ECT (in press)
  • 査読あり
• [雑誌論文] Evaluation of QT interval and QT dispersion in patients with major depression. (2008)
  • 著者名/発表者名: Yamaguchi S, Tezuka N, et al.
  • 雑誌名: Anesthesiology 109
  • 査読あり
• [雑誌論文] Movement of the cauda equina in the subarachnoid space during the lateral decubitus position with or fully flexed legs in children. (2008)
  • 著者名/発表者名: Yamaguchi S, Tezuka N,et al.
  • 雑誌名: Anesthesia and Analgesia 160
  • 査読あり
• [雑誌論文] Assessment of QT interval and QT dispersion during electroconvulsive therapy using computerized measurements. (2008)
  • 著者名/発表者名: Tezuka N, Yamaguchi S,et al.
  • 雑誌名: Anesthesia and Analgesia 160
  • 査読あり
• [雑誌論文] Evaluation of QT interval and QT dispersion in patients with major depression (2008)
  • 著者名/発表者名: Yamaguchi S, Tezuka N, et al
  • 雑誌名: Anesthesiology 109
  • 査読あり
• [雑誌論文] Movement of the cauda equina in the subarachnoid space during the lateral decubitus position with or fully flexed legs in children (2008)
  • 著者名/発表者名: Yamaguchi S, Tezuka N, et al.
  • 雑誌名: Anesthesia and Analgesia 106
  • 査読あり
• [雑誌論文] Assessment of QT interval and QT dispersion during electroconvulsive therapy using computerized measurements (2008)
  • 著者名/発表者名: Tezuka N, Yamaguchi s, et al.
  • 雑誌名: Anesthesia and Analgesia 106
  • 査読あり
• [雑誌論文] Comparison of 0.25% levobupivacain 0.25% bupivavaine, and 0.125% bupivacaine for duration and magnitude of action in peripheral arterial blood flow induced by sympathetic block in dogs. (2007)
  • 著者名/発表者名: Iwasaki T, Yamaguchi S, et al.
  • 雑誌名: Regional Anesthesia and Pain Medicine 32 ページ: 97-101
  • 査読あり
• [雑誌論文] NMDA receptor 2B subunit-mediated synap transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice. (2007)
  • 著者名/発表者名: Iwata H, Yamaguchi S, et al.
  • 雑誌名: Brain Research 1135 ページ: 92-101
  • 査読あり
• [雑誌論文] Comparison of 0.2% ropivacaine and 0.25% bupivacaine in pediatric caudal block:evaluation of postoperative paiplasma concentration of local anesthetics. (2007)
  • 著者名/発表者名: Hashizume Y, Yamaguchi S, et al.
  • 雑誌名: Dokkyo Journal of Medical Sciences 34 ページ: 1-6
  • 査読あり
• [雑誌論文] Morphological finding of the cauda equine in children during the lateral decubitus position. (2007)
  • 著者名/発表者名: Yamaguchi S, Furukawa T, et al.
  • 雑誌名: Anesthesia and Analgesia 104
  • 査読あり
• [雑誌論文] The shift of the cauda equine in children is not obvious during the lateral ducubituposition. (2007)
  • 著者名/発表者名: Yamaguchi S, Takiguchi T, et al.
  • 雑誌名: Anesthesiology 106
  • 査読あり
• [雑誌論文] Large-conductance, calcium-activated potassium channels control excsynaptic transmission in the superficial dorsal horn of the mouse spinal cord. (2007)
  • 著者名/発表者名: Takasusuki T, Yamaguchi S, et al.
  • 雑誌名: FASEB Journal 21 ページ: 911-911
  • 査読あり
• [雑誌論文] Comparison of 0.25% levobupivacaine,0.25% bupivavaine,and 0.125% bupivacaine for duration and magnitude of action in peripheral arterial blood flow induced by sympathetic block in dogs (2007)
  • 著者名/発表者名: Iwasaki T, Yamaguchi S, Kitajima T, et. al.
  • 雑誌名: Reg Anesth Pain Med 32 ページ: 97-101
  • 査読あり
• [雑誌論文] NMDA receptor 2B subunit-mediated synaptic transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice (2007)
  • 著者名/発表者名: Iwata H, Yamaguchi S, Hori Y, et. al.
  • 雑誌名: Brain Research 1135 ページ: 92-101
  • 査読あり
• [雑誌論文] Comparison of 0.2% ropivacaine and 0.25% bupivacaine in pediatric caudal block;evaluation of postoperative pain and plasma concentration of local anesthetics (2007)
  • 著者名/発表者名: Hashizume Y, Yamaguchi S, Fukagawa D, et. al.
  • 雑誌名: Dokkyo J Med Sci 34 ページ: 1-6
  • 査読あり
• [雑誌論文] Morphological finging of the cauda equine in children during the lateral decubitus position (2007)
  • 著者名/発表者名: Yamaguchi S, Furukawa T, Takiguchi T, et. al.
  • 雑誌名: Anesth Analg 104
  • 査読あり
• [雑誌論文] The shift of the cauda equine in children is not obvious during the lateral ducubitus position (2007)
  • 著者名/発表者名: Yamaguchi S, Takiguchi T, furukawa N, et. al.
  • 雑誌名: Anesthesiology 106
  • 査読あり
• [雑誌論文] Large-conductance,calcium-activated potassium channels control excitatory synaptic transmission in the superficial dorsal horn of the mouse spinal cord (2007)
  • 著者名/発表者名: Takasusuki T, yamaguchi S, Hori Y, et. al.
  • 雑誌名: FASEB J 21 ページ: 911-911
  • 査読あり
• [学会発表] Altered nociceptive response and NMDAreceptor-mediated synaptic transmission in the superficial dorsal horn of the spinal cord in serine racemase knockout mice (2008)
  • 著者名/発表者名: Takasusuki T, Yamaguchi S, et al
  • 学会等名: Society for Neuroscience 2008 Annual Meeting
  • 発表場所: Washington DC, US
  • 年月日: 2008-11-18
• [学会発表] Altered nociceptive response and NMDA receptor-mediated synaptic transmission in the superficial dorsal horn of the spinal cord in serine racemase knockout mice (2008)
  • 著者名/発表者名: Takasusuki T, Yamaguchi S, et al
  • 学会等名: Society for Neuroscience2009 Annual Meeting
  • 発表場所: Washington DC, US
  • 年月日: 2008-11-18
• [学会発表] N-methyl-D-aspartate receptor-mediated synaptic transmission in neurons containing serotonin or GABA in the ventrolateral subdivision of the periaqueductal gray matter of themouse (2008)
  • 著者名/発表者名: Furukawa N, Yamaguchi S, et al
  • 学会等名: Society for Neuroscience 2009 Annual Meeting
  • 発表場所: Washington DC, US
  • 年月日: 2008-11-16
• [学会発表] N-methyl-D-aspartate receptor-mediated synaptic transmission in neurons containing serotonin or GABA in the ventrolateral subdivision of the periaqueductal gray matter of the mouse (2008)
  • 著者名/発表者名: Furukawa N, Yamaguchi S, Et al.
  • 学会等名: Society for Neuroscience2009 Annual Meeting
  • 発表場所: Washington DC, US
  • 年月日: 2008-11-16
• [学会発表] Evaluation of QT interval and QT dispersion in patients with major depression (2008)
  • 著者名/発表者名: Yamaguchi S, Tezuka N, et al
  • 学会等名: American Society of Anesthesiology 2009 Annual Meeting
  • 発表場所: Orland, US
  • 年月日: 2008-10-22
• [学会発表] Evaluation of QT interval and QT dispersion in patients with major Depression (2008)
  • 著者名/発表者名: Yamaguchi S, Tezuka N, et al
  • 学会等名: American Society of Anesthesiology2009 Annual Meeting
  • 発表場所: Orland, US
  • 年月日: 2008-10-22
• [学会発表] Pre- and postsynaptic mechanisms for plasticity of nociceptive processing in the spinal superficial dorsaof adult micePre- and postsynaptic mechanisms for plasticity of nociceptive processing in the spinal superficial dorsal horn of adult mice (2007)
  • 著者名/発表者名: Takasusuki T, Yamaguchi S, et al
  • 学会等名: Society forNeuroscience 2007 Annual Meeting
  • 発表場所: San Diego, US
  • 年月日: 2007-11-04
• [学会発表] Pre- and postsynaptic mechanisms for plasticity of nociceptive processing in the spinal superficial dorsal horn of adult mice (2007)
  • 著者名/発表者名: Takasusuki T, Yamaguchi S, Hori Y, et. al.
  • 学会等名: 2007 Neuroscience meeting
  • 発表場所: San Diego,US
  • 年月日: 2007-11-04
• [学会発表] Sympathectomy with radiofrequency thermocoagulation induces significant increase of peripheral artery blood flow compared with sympathetic block with mepivacaine in dogs (2007)
  • 著者名/発表者名: Shinozaki M, Yamaguchi S, et al
  • 学会等名: European Society of Regional Anesthesia & Pain Therapy
  • 発表場所: Valencia, Spain
  • 年月日: 2007-09-14
• [学会発表] Sympathectomy with radiofrequency thermocoagulation induces singificant increase of peripheral artery blood flow compared with symapathetic block with mepivacaine in dogs (2007)
  • 著者名/発表者名: Shinozaki M, Yamaguchi S, Iwasaki T, et. al.
  • 学会等名: European Society of Regional Anesthesia & Pain Therapy
  • 発表場所: Valencia,Spain
  • 年月日: 2007-09-14