難治性造血器腫瘍の分子病態と治療標的の解明

• 研究課題/領域番号: 19679004
• 研究種目: 若手研究(S)
• 配分区分: 補助金
• 研究分野: 血液内科学
• 研究機関: 東京大学
• 研究代表者: 黒川 峰夫 東京大学, 医学部・附属病院, 教授 (80312320)
• 研究期間 (年度): 2007 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 100,490千円 (直接経費: 77,300千円、間接経費: 23,190千円); 2011年度: 20,280千円 (直接経費: 15,600千円、間接経費: 4,680千円); 2010年度: 20,280千円 (直接経費: 15,600千円、間接経費: 4,680千円); 2009年度: 20,280千円 (直接経費: 15,600千円、間接経費: 4,680千円); 2008年度: 19,630千円 (直接経費: 15,100千円、間接経費: 4,530千円); 2007年度: 20,020千円 (直接経費: 15,400千円、間接経費: 4,620千円)
• キーワード: 白血病 / 造血幹細胞 / 白血病幹細胞 / 血液腫瘍学 / Evi-1 / Runx1 / NF-κB / 血液種瘍学 / AML1

研究概要

本研究では、転写因子Evi-1のエピジェネティックな転写制御がEvi-1の白血病原性に重要であることを明らかにした。また、AML1を条件的に欠失するマウスを用いて、AML1の機能欠損が白血病を促進する新しい分子機構を明らかにした。さらに、Evi-1を条件的に欠失するマウスおよびEvi-1の発現を可視化したマウスを作製し、Evi-1と造血幹細胞、白血病幹細胞との特有の関係性を明らかにした。これらは、白血病などの難治性造血器腫瘍に対する新たな分子標的療法を開発する上で貴重な成果である。

研究成果

• [雑誌論文] Hepatocellular carcinoma in cirrhotic liver with graft-versus-host disease (2012)
  • 著者名/発表者名: Yoshimi A, Yamamoto G, Goto T, Koike K, Kurokawa M
  • 雑誌名: Annals of Hematology 巻: (In press) 号: 9 ページ: 1501-1502
  • DOI: 10.1007/s00277-012-1416-3
  • 年月日: 2012-02-09
  • 査読あり
• [雑誌論文] Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation : a nationwide retrospective study (2012)
  • 著者名/発表者名: Junya Kanda
  • 雑誌名: Blood 巻: 119 号: 10 ページ: 2409-2416
  • DOI: 10.1182/blood-2011-08-372573
  • 査読あり
• [雑誌論文] The first case of blastic plasmacytoid dendritic cell neoplasm with MLL-ENL rearrangement (2012)
  • 著者名/発表者名: Toya T, Nishimoto N, Koya J, Nakagawa M, Nakamura F, Kandabashi K, Yamamoto G, Nannya Y, Ichikawa M, Kurokawa M
  • 雑誌名: Leukemia Research 巻: 36 号: 1 ページ: 117-118
  • DOI: 10.1016/j.leukres.2011.07.029
  • 査読あり
• [雑誌論文] Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity (2011)
  • 著者名/発表者名: Keisuke Kataoka
  • 雑誌名: The Journal of Experimental Medicine 巻: 208 号: 12 ページ: 2403-2416
  • DOI: 10.1084/jem.20110447
  • 査読あり
• [雑誌論文] AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors (2011)
  • 著者名/発表者名: Masahiro Nakagawa
  • 雑誌名: Blood 巻: 118 号: 25 ページ: 6626-6637
  • DOI: 10.1182/blood-2010-12-326710
  • 査読あり
• [雑誌論文] Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl (2011)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Cancer Science 巻: 102 号: 12 ページ: 2109-2117
  • DOI: 10.1111/j.1349-7006.2011.02066.x
  • 査読あり
• [雑誌論文] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through downregulation of p19ARF (2011)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Blood 巻: 118 号: 9 ページ: 2541-2550
  • DOI: 10.1182/blood-2010-10-315440
  • 査読あり
• [雑誌論文] Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins (2011)
  • 著者名/発表者名: Yoshimi Akihide
  • 雑誌名: Blood 巻: 117 号: 13 ページ: 3617-28
  • DOI: 10.1182/blood-2009-12-261602
  • 査読あり
• [雑誌論文] Evi-1 is a transcriptional target of MLL oncoproteins in hematopoietic stem cells (2011)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Blood 巻: 117 号: 23 ページ: 6304-6314
  • DOI: 10.1182/blood-2009-07-234310
  • 査読あり
• [雑誌論文] The effect of iron overload and chelation on erythroid differentiation (2011)
  • 著者名/発表者名: Taoka K, Kumano K, Nakamura F, Hosoi M, Goyama S, Imai Y, Hangaishi A, Kurokawa M
  • 雑誌名: International Journal of Hematology 巻: 95 号: 2 ページ: 149-159
  • DOI: 10.1007/s12185-011-0988-3
  • NAID: 10030267276
  • 査読あり
• [雑誌論文] Temozolomide may induce therapy-related acute lymphoblastic leukaemia (2011)
  • 著者名/発表者名: Ogura M, Todo T, Tanaka M, Nannya Y, Ichikawa M, Nakamura F, Kurokawa M
  • 雑誌名: British Journal of Haematology 巻: 154 号: 5 ページ: 663-665
  • DOI: 10.1111/j.1365-2141.2011.08641.x
  • 査読あり
• [雑誌論文] Hyperbilirubinemia after hematopoietic stem cell transplantation : comparison of clinical and pathologic findings in 41 autopsied cases (2011)
  • 著者名/発表者名: Kagoya Y, Takahashi T, Nannya Y, Shinozaki A, Ota S, Fukayama M, Kurokawa M
  • 雑誌名: Clinical Transplantation 巻: 25 号: 5
  • DOI: 10.1111/j.1399-0012.2011.01498.x
  • 査読あり
• [雑誌論文] Evi1 forms a bridge between the epigenetic machinery and signaling pathways (2011)
  • 著者名/発表者名: Yoshimi A, Kurokawa M
  • 雑誌名: Oncotarget 巻: 2 ページ: 575-586
  • 査読あり
• [雑誌論文] Nilotinib as frontline therapy for patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase : results from the Japanese subgroup of ENESTnd (2011)
  • 著者名/発表者名: Nakamae H, Shibayama H, Kurokawa M, Fukuda T, Nakaseko C, Kanda Y, Nagai T, Ohnishi K, Maeda Y, Matsuda A, Amagasaki T, Yanada M
  • 雑誌名: International Journal of Hematology 巻: 93 号: 5 ページ: 624-632
  • DOI: 10.1007/s12185-011-0841-8
  • NAID: 10029535125
  • 査読あり
• [雑誌論文] The negative impact of female donor/male recipient combination in allogeneic hematopoietic stem cell transplantation depends on disease risk (2011)
  • 著者名/発表者名: Yasuhito Nannya
  • 雑誌名: Transplant International 巻: 24 号: 5 ページ: 469-476
  • DOI: 10.1111/j.1432-2277.2011.01229.x
  • 査読あり
• [雑誌論文] Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation (2011)
  • 著者名/発表者名: Nakaseko C, Ozawa S, Sakaida E, Sakai M, Kanda Y, Oshima K, Kurokawa M, Takahashi S, Ooi J, Shimizu T, Yokota A, Yoshiba F, Fujimaki K, Kanamori H, Sakai R, Saitoh T, Sakura T, Maruta A, Sakamaki H, Okamoto S
  • 雑誌名: International Journal of Hematology 巻: 93 号: 3 ページ: 375
  • DOI: 10.1007/s12185-011-0809-8
  • NAID: 10029534020
  • 査読あり
• [雑誌論文] Nilotinib-induced hypothyroidism in a patient with chronic myeloid leukemia (2011)
  • 著者名/発表者名: Yoshizato T, Nannya Y, Yoshiki Y, Nakamura F, Imai Y, Ichikawa M, Kurokawa M
  • 雑誌名: International Journal of Hematology 巻: 93 号: 3 ページ: 400-402
  • DOI: 10.1007/s12185-011-0790-2
  • NAID: 10029534100
  • 査読あり
• [雑誌論文] A Case of Myeloid Sarcoma with Correlation to JAK2V617F Mutation, Complicated by Myelofibrosis and Secondary Acute Myeloid Leukemia (2011)
  • 著者名/発表者名: Yoshiki Y, Asai T, Ichikawa M, Hangaishi A, Ota S, Imai Y, Takahashi T, Kurokawa M
  • 雑誌名: Internal Medicine 巻: 50 号: 21 ページ: 2649-2652
  • DOI: 10.2169/internalmedicine.50.5783
  • NAID: 130001288629
  • ISSN: 0918-2918, 1349-7235
  • 査読あり
• [雑誌論文] Evi-1 is a transcriptional target of MLL oncoproteins in hematopoietic stem cells. (2011)
  • 著者名/発表者名: Arai S, Yoshimi A, Shimabe M, Ichikawa M, Nakagawa M, Imai Y, Goyama S, Kurokawa M
  • 雑誌名: Blood 巻: (掲載確定)(in press)
  • 査読あり
• [雑誌論文] Haemophagocytic lymphohistiocytosis is a recurrent and specific complication of acute erythroid leukaemia. (2011)
  • 著者名/発表者名: Yamazaki S, Nakamura F, Nasu R, Nannya Y, Ichikawa M, Kurokawa M.
  • 雑誌名: British Journal of Haematology 巻: (掲載確定)(in press)
  • 査読あり
• [雑誌論文] Temozolomide may induce therapy-related acute lymphoblastic leukaemia. (2011)
  • 著者名/発表者名: Ogura M, Todo T, Tanaka M, Nannya Y, Ichikawa M, Nakamura F, Kurokawa M.
  • 雑誌名: British Journal of Haematology 巻: (掲載確定)(in press)
  • 査読あり
• [雑誌論文] Evil represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. (2011)
  • 著者名/発表者名: Yosbimi A, Goyama S, Watanabe-Okochi N, Yoehiki Y, Nannya Y, Nitta E, Arai S, Sato T, Shimabe M, Nakagawa M, Imai Y, Kitamura T, Kurokawa M.
  • 雑誌名: Blood 巻: 117 ページ: 415-424
  • 査読あり
• [雑誌論文] Notch2 signaling is requixed for proper mast cell distribution and mucosal immunity in the intestine. (2011)
  • 著者名/発表者名: Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S.
  • 雑誌名: Blood 巻: 117 ページ: 128-134
  • 査読あり
• [雑誌論文] Pretransplant predictors and posttransplant sequels of acute kidney injury after allogeneic stem cell transplantation. (2011)
  • 著者名/発表者名: Kagoya Y, Kataoka K, Nannya Y, Kurokawa M
  • 雑誌名: Biology of Blood and Marrow Transplantation 巻: 17 ページ: 394-400
  • 査読あり
• [雑誌論文] The negative impact of female donor/male recipient combination in allogeneic hematopoietic stem cell transplantation depends on disease risk. (2011)
  • 著者名/発表者名: Nannya Y, Kataoka K, Hangaishi A, Imai Y, Takahashi T, Kurokawa M.
  • 雑誌名: Tranaplant International 巻: 24 ページ: 469-476
  • 査読あり
• [雑誌論文] Key roles of histone methyltransferase and demethylase in leukemogenesis. (2011)
  • 著者名/発表者名: Yoshimi A, Kurokawa M.
  • 雑誌名: Journal of Cellular Biochemistry 巻: 112 ページ: 415-424
  • 査読あり
• [雑誌論文] Poat-transplant lymphoproliferative disorder after adult-to-adult living donor liver transplant : case series and review of literature. (2011)
  • 著者名/発表者名: Kataoka K, Seo S, Sugawara Y, Ota S, Imai Y, Takahashi T, Fukayama M, Kokudo N, Kurokawa M.
  • 雑誌名: Leukemia & Lymphoma 巻: 51 ページ: 1494-1501
  • 査読あり
• [雑誌論文] EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization (2010)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Leukemia 巻: 24 号: 1 ページ: 81-88
  • DOI: 10.1038/leu.2009.202
  • 査読あり
• [雑誌論文] AML1 enhances the epression of leukotriene B4 type-1 receptor in leukocytes (2010)
  • 著者名/発表者名: 橋立智美、中村元直、中川正宏、市川幹、黒川峰夫、清水孝雄
  • 雑誌名: FASEB Journal 巻: 24 号: 9 ページ: 3500-3510
  • DOI: 10.1096/fj.10-156844
  • 査読あり
• [雑誌論文] A novel MLL-AF1p/Eps15 fusion variant in therapy-related acute lymphoblastic leukemia, lacking the EH-domains (2010)
  • 著者名/発表者名: 篠原明仁、市川幹、植田航希、高橋強志、半下石明、黒川峰夫
  • 雑誌名: Leukemia Research 巻: 34 号: 2 ページ: 62-63
  • DOI: 10.1016/j.leukres.2009.07.028
  • 査読あり
• [雑誌論文] The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells (2010)
  • 著者名/発表者名: 熊野恵城、黒川峰夫
  • 雑誌名: The Journal of Cellular Physiology 巻: 222 号: 2 ページ: 282-285
  • DOI: 10.1002/jcp.21953
  • 査読あり
• [雑誌論文] T cell acute lymphoblastic leukemia arising from familial platelet disorder. (2010)
  • 著者名/発表者名: Nishimoto N, Imai Y, Ueda K, Nakagawa M, Shinohara A, Ichikawa M, Nannya Y, Kurokawa M.
  • 雑誌名: International Journal of Hematology 巻: 92 ページ: 194-197
  • NAID: 10026512453
  • 査読あり
• [雑誌論文] Outcome and treatment of late-onset noninfectious pulmonary complications after allogeneic haematopoietic SCT. (2010)
  • 著者名/発表者名: Ueda K, Watadani T, Maeda E, Ota S, Kataoka K, Seo S, Kumano K, Hangaishi A, Takahashi T, Imai Y, Ohtomo K, Fukayama M, Nannya Y, Kurokawa M
  • 雑誌名: Bone Marrow Transplantation 巻: 45 ページ: 1719-1727
  • 査読あり
• [雑誌論文] Plasma brain natriuretic peptide is associated with hepatic veno-occlusive disease and early mortality after allogeneic hematopoietic stem cell transplantation. (2010)
  • 著者名/発表者名: Kataoka K, Nannya Y, Iwata H, Seo S, Kumano K, Takahashi T, Nagai R, Kurokawa M.
  • 雑誌名: Bone Marrow Transplantation 巻: 45 ページ: 1631-1637
  • 査読あり
• [雑誌論文] FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy. (2010)
  • 著者名/発表者名: Ueda K, Ichikawa M, Takahashi M, Momose T, Ohtomo K, Kurokawa M.
  • 雑誌名: Leukemia Research 巻: 34 ページ: 1239-1241
  • 査読あり
• [雑誌論文] The impact of molecularly targeted therapies upon the understanding of leukemogenesis and the role of hematopoietic stem cell transplantation in acute promyelocytic leukemia. (2010)
  • 著者名/発表者名: Nagai S, Takahashi T, Kurokawa M.
  • 雑誌名: Current Stem Cell Research & Therapy 巻: 5 ページ: 372-378
  • 査読あり
• [雑誌論文] Evi-1 as a critical regulator of leukemic cells. (2010)
  • 著者名/発表者名: Goyama S, Kurokawa M.
  • 雑誌名: International Journal of Hematology 巻: 91 ページ: 753-757
  • NAID: 10026510900
  • 査読あり
• [雑誌論文] AML1 enhances the expression of leukotriene B4 type-1 receptor in leukocytes. (2010)
  • 著者名/発表者名: Hashidate T, Murakami N, Nakagawa M, Ichikawa M, Kurokawa M, Shimizu T, Nakamura M.
  • 雑誌名: FASEB Journal 巻: 24 ページ: 3500-3510
  • 査読あり
• [雑誌論文] Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia : comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission. (2010)
  • 著者名/発表者名: Nishiwaki S, Inamoto Y, Sakamaki H, Kurokawa M, Iida H, Ogawa H, Fukuda T, Ozawa Y, Kobayashi N, Kasai M, Mori T, Iwato K, Yoshida T, Onizuka M, Kawa K, Morishima Y, Suzuki R, Atsuta Y, Miyamura K.
  • 雑誌名: Blood 巻: 116 ページ: 4368-4375
  • 査読あり
• [雑誌論文] Hesl immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (2010)
  • 著者名/発表者名: Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S.
  • 雑誌名: Blood 巻: 115 ページ: 2872-2881
  • 査読あり
• [雑誌論文] EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization (2010)
  • 著者名/発表者名: Goyama S, Nitta E, Yoshino T, Kako S, Watanabe-Okochi N, Shimabe M, Imai Y, Takahashi K, Kurokawa M.
  • 雑誌名: Leukemia 24 ページ: 81-8
• [雑誌論文] AML1 enhances the epression of leukotriene B4 type-1 receptor in leukocytes. (2010)
  • 著者名/発表者名: Hashidate T, Nakamura M, Nakagawa M, Ichikawa M, Kurokawa M, Shimizu T.
  • 雑誌名: FASEB Journal (in press)
  • 査読あり
• [雑誌論文] Essential roles of VLA-4 in the hematopoietic system. (2010)
  • 著者名/発表者名: Imai Y, Shimaoka M, Kurokawa M.
  • 雑誌名: International Journal of Hematology (in press)
  • NAID: 10026401695
  • 査読あり
• [雑誌論文] The impact of molecularly targeted therapies upon the understanding of leukemogenesis and the role of hematopietic stem cell transplantation in acute promyelocytic leukemia. (2010)
  • 著者名/発表者名: Nagai S, Takahashi T, Kurokawa M.
  • 雑誌名: Current Stem Cell Research and Therapy (in press)
  • 査読あり
• [雑誌論文] Complete molecular remission in refractory acute myeloid leukemia with MLL/AF9 treated with gemtuzumab ozogamicin. (2010)
  • 著者名/発表者名: Asano H, Yamamoto G, Hosoi M, Takahashi T, Hangaishi A, Kurokawa M.
  • 雑誌名: Leukemia Research (in press)
  • 査読あり
• [雑誌論文] Jumping translocation involving lq21 during long-term complete remission of acute myeloid leukemia. (2010)
  • 著者名/発表者名: Nagai S, Nannya Y, Takahashi T, Kurokawa M.
  • 雑誌名: Annals of Hematology (in press)
  • 査読あり
• [雑誌論文] Blimp-1 is a tumor suppressor gene in lymphoid malignancies. (2010)
  • 著者名/発表者名: Hangaishi A, Kurokawa M.
  • 雑誌名: International Journal of Hematology 91 ページ: 46-53
  • NAID: 10026110550
  • 査読あり
• [雑誌論文] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (2010)
  • 著者名/発表者名: Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S.
  • 雑誌名: Blood 115 ページ: 2872-2881
  • 査読あり
• [雑誌論文] Risk-adapted maintenance therapy for acute promyelocytic leukemia. (2010)
  • 著者名/発表者名: Nagai S, Takahashi T, Kurokawa M.
  • 雑誌名: Journal of Clinical Oncology 28
  • 査読あり
• [雑誌論文] EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization. (2010)
  • 著者名/発表者名: Goyama S, Nitta E, Yoshino T, Kako S, Watanabe-Okochi N, Shimabe M, Imai Y, Takahashi K, Kurokawa M.
  • 雑誌名: Leukemia 24 ページ: 81-88
  • 査読あり
• [雑誌論文] Molecular or cytogenetic monitoring and preemptive therapy for centralnervous system relapse of acute promyelocytic leukemia. (2010)
  • 著者名/発表者名: Nagai S, Nannya Y, Arai S, Yoshiki Y, Takahashi T, Kurokawa M.
  • 雑誌名: Haematologica 95 ページ: 169-171
  • 査読あり
• [雑誌論文] A novel MLL-AF1p/Eps15 fusion variant in therapy-related acute lymphoblastic leukemia, lacking the EH-domains. (2010)
  • 著者名/発表者名: Shinohara A, Ichikawa M, Ueda K, Takahashi T, Hangaishi A, Kurokawa M.
  • 雑誌名: Leukemia Research 34
  • 査読あり
• [雑誌論文] The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells. (2010)
  • 著者名/発表者名: Kumano K, Kurokawa M.
  • 雑誌名: The Journal of Cellular Physiology 222 ページ: 282-285
  • 査読あり
• [雑誌論文] Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells (2009)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Oncogene 巻: 10 号: 49 ページ: 4364-4374
  • DOI: 10.1038/onc.2009.288
  • 査読あり
• [雑誌論文] Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies (2009)
  • 著者名/発表者名: 合山進、黒川峰夫
  • 雑誌名: Cancer Science 巻: 100 号: 6 ページ: 990-995
  • DOI: 10.1111/j.1349-7006.2009.01152.x
  • NAID: 10025146207
  • 査読あり
• [雑誌論文] Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells (2009)
  • 著者名/発表者名: Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, Imai Y, Kurokawa M.
  • 雑誌名: Oncogene 28 ページ: 4364-74
• [雑誌論文] Dual antitumor mechanisms of Notch signaling inhibitor in a T cell acute lymphoblastic leukemia xenograft model. (2009)
  • 著者名/発表者名: Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S.
  • 雑誌名: Cancer Science 100 ページ: 2444-2450
  • NAID: 10027198807
  • 査読あり
• [雑誌論文] Arsenic-induced pericardial and pleural effusion without acute promyelocytic leukemia differentiation syndrome. (2009)
  • 著者名/発表者名: Ueda K, Nagai S, Miyashita S, Kaise T, Ichikawa M, Kumano K, Hangaishi A, Nannya Y, Kurokawa M.
  • 雑誌名: Leukemia Research 34
  • 査読あり
• [雑誌論文] Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. (2009)
  • 著者名/発表者名: Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, Imai Y, Kurokawa M.
  • 雑誌名: Oncogene 10 ページ: 4364-4374
  • 査読あり
• [雑誌論文] Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-151. (2009)
  • 著者名/発表者名: Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
  • 雑誌名: The Journal of Immunology 15 ページ: 6186-6178
  • 査読あり
• [雑誌論文] NEDD9 is required for activation of oncogenic signaling pathways in mammary tumor development. (2009)
  • 著者名/発表者名: Izumchenko E, Plotnikova O, Singh M, Tikhmyanova N, Little J, Seo S, Kurokawa M, Egleston B, Klein-Szanto AJ, Pugacheva E, Hardy R, Connolly D, Wolfson M, Golemis E.
  • 雑誌名: Cancer Research 15 ページ: 7198-7206
  • 査読あり
• [雑誌論文] Beneficial and adverse effects of molecularly targeted therapies for acute promyelocytic leukemia in central nervous system. (2009)
  • 著者名/発表者名: Nagai S, Takahashi T, Kurokawa M.
  • 雑誌名: CNS and Neurological Disorders-Drug Targets 8 ページ: 387-392
  • 査読あり
• [雑誌論文] Derivation of functional mature neutrophils from human embryonic stem cells. (2009)
  • 著者名/発表者名: Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S.
  • 雑誌名: Blood 113 ページ: 6584-6592
  • NAID: 120007131544
  • 査読あり
• [雑誌論文] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. (2009)
  • 著者名/発表者名: Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S.
  • 雑誌名: Cancer Science 100 ページ: 920-926
  • NAID: 10025145854
  • 査読あり
• [雑誌論文] Evidence for basophilic differentiation of acute promyelocytic leukemia cells during arsenic trioxide therapy. (2009)
  • 著者名/発表者名: Masamoto Y, Nannya Y, Arai S, Koike Y, Hangaishi A, Yatomi Y, and Kurokawa M.
  • 雑誌名: British Journal of Haematology 144 ページ: 798-799
  • 査読あり
• [雑誌論文] Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation. (2009)
  • 著者名/発表者名: Kataoka K, Nannya Y, Hangaishi A, Imai Y, Chiba S, Takahashi T, and Kurokawa M.
  • 雑誌名: Biology of Blood and Marrow Transplantation 15 ページ: 195-204
  • 査読あり
• [雑誌論文] Successful haematopoietic stem cell transplantation from an HLA-identical sibling in a patient with aplastic anemia following HLA-haploidentical living-related liver transplantation for fulminant hepatitis. (2009)
  • 著者名/発表者名: Yoshimi A, Nannya Y, Asano D, Yamamoto G, Kumano K, Hangaishi A, Matsui Y, Takahashi T, Imai Y, Kokudo N, and Kurokawa M.
  • 雑誌名: Biology of Blood and Marrow Transplantation 15 ページ: 389-390
  • 査読あり
• [雑誌論文] Acute eosinophilic pneumonia is a non-infectious lung complication after allogeneic hematopoietic stem cell transplantation. (2009)
  • 著者名/発表者名: Yoshimi M, Nannya Y, Watanabe T, Asai T, Ichikawa M, Yamamoto G, Kumano K, Hangaishi A, Imai Y, Takahashi T, Chiba S, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 89 ページ: 244-248
  • NAID: 10025160410
  • 査読あり
• [雑誌論文] A new three-way variantt(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia. (2009)
  • 著者名/発表者名: Kato T, Hangaishi A, Ichikawa M, Motokura T, Takahashi T, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 89 ページ: 204-208
  • NAID: 10025160251
  • 査読あり
• [雑誌論文] Pathogenetic significance of EVI-1 in hematological malignancies. (2009)
  • 著者名/発表者名: Goyama S and Kurokawa M.
  • 雑誌名: Cancer Science (in press)
  • 査読あり
• [雑誌論文] The race and dose of chemotherapy should be considered for optimizing maintenance therapy for acute promyelocytic leukemia. (2009)
  • 著者名/発表者名: Nagai S, Nannya Y, Hangaishi A, Takahashi T, and Kurokawa M.
  • 雑誌名: Leukemia Research (in press)
  • 査読あり
• [雑誌論文] Simultaneous appearance of methotrexate-associated lymphoproliferative disorder and tuberculous meningitis demonstrating the definitive role of immunosuppression. (2009)
  • 著者名/発表者名: Nagai 5, Izutsu K, Watanabe T, and Kurokawa M.
  • 雑誌名: Annals of Hematology (in press)
  • 査読あり
• [雑誌論文] Hemoperitoneum due to spontaneous rupture of the left gastroepiploic artery in a patient with hemophilia A. (2009)
  • 著者名/発表者名: Yoshimi A, Takahashi T, Motokura T, Yatomi Y, Chiba S, and Kurokawa M.
  • 雑誌名: Annals of Hematology (in press)
  • 査読あり
• [雑誌論文] Early onset of acute lymphoblastic leukemia with MLL rearrangement after autologous stem cell transplantation for multiple myeloma. (2009)
  • 著者名/発表者名: Ueda K, Yamamoto G, Shinohara A, Hangaishi A, and Kurokawa M.
  • 雑誌名: Annals of Hematology (in press)
  • 査読あり
• [雑誌論文] Monitoring trough concentration of voriconazole is important to ensure successful antifungal therapy and to avoid hepatic damage in patients with hematological disorders. (2009)
  • 著者名/発表者名: Ueda K, Nannya Y, Kumano K, Hangaishi A, Takahashi T, Imai Y, and Kurokawa M.
  • 雑誌名: International Journal of Hematology (in press)
  • NAID: 10025161759
  • 査読あり
• [雑誌論文] Chronic myelomonocytic leukemia presenting as hemorrhagic shock due to uterine infiltration of leukemic cells and early-stage endometrial adenocarcinoma. (2009)
  • 著者名/発表者名: Yoshimi A, Asai T, Maeda D, Hangaishi A, Sakatani T, Takahashi T, Imai Y, Fukayama M, and Kurokawa M.
  • 雑誌名: Archives of Gynecology and Obstetrics (in press)
  • 査読あり
• [雑誌論文] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells (2008)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Cell Stem Cell 巻: 3 号: 2 ページ: 207-220
  • DOI: 10.1016/j.stem.2008.06.002
  • NAID: 40019064494
  • 査読あり
• [雑誌論文] AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis (2008)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: The Journal of Immunology 巻: 180 ページ: 4402-4408
  • URL: http://www.jimmunol.org/content/180/7/4402
  • 査読あり
• [雑誌論文] AML1-Evi-1 specifically transforms hematopoieticstem cells through fusion of the entire Evi-1 sequence to AML1 (2008)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Leukemia 巻: 22 号: 6 ページ: 1241-1249
  • DOI: 10.1038/leu.2008.53
  • 査読あり
• [雑誌論文] Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-βsignaling (2008)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Cancer Science 巻: 99 号: 7 ページ: 1407-1413
  • DOI: 10.1111/j.1349-7006.2008.00842.x
  • NAID: 10024008671
  • 査読あり
• [雑誌論文] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells (2008)
  • 著者名/発表者名: Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
  • 雑誌名: Cell Stem Cell 3 ページ: 207-20
  • NAID: 40019064494
• [雑誌論文] AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis (2008)
  • 著者名/発表者名: Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M.
  • 雑誌名: Journal of Immunology 180 ページ: 4402-8
• [雑誌論文] AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1 (2008)
  • 著者名/発表者名: Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.
  • 雑誌名: Leukemia 22 ページ: 1241-9
• [雑誌論文] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. (2008)
  • 著者名/発表者名: T, Ichikawa M, Ogawa S, Chiba S, and Kurokawa M.
  • 雑誌名: Cell Stem Cell 3 ページ: 207-220
  • NAID: 40019064494
  • 査読あり
• [雑誌論文] Successful engraftment following HLA-mismatched cord blood transplantation for patients with anti-HLA antibodies. (2008)
  • 著者名/発表者名: Kataoka K, Yamamoto G, Nannya Y, Yoshimi A, Okada S, Asai T, Kumano K, Hangaishi A, Takahashi T, Chiba S, and Kurokawa M.
  • 雑誌名: Bone Marrow Transplantation 42 ページ: 129-130
  • 査読あり
• [雑誌論文] Antileukemic immunity associated with antineutrophil antibody production after allogeneic hematopoietic stem cell transplantation for myeloid/NK-cell precursor acute leukemia. (2008)
  • 著者名/発表者名: Suzuki H, Suzuki T, Kamijo A, Ohta S, Sato H, Hangaishi A, Takahashi T, Kanda Y, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: Antileukemic immunity associated with antineutrophil antibody production after allogeneic hematopoietic stem cell transplantation for myeloid/NK-cell precursor acute leukemia. 42 ページ: 285-287
  • 査読あり
• [雑誌論文] Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI. (2008)
  • 著者名/発表者名: Nakagawa K, Kanda Y, Yamashita H, Nakagawa S, Sasano N, Ohtomo K, Oshima K, Kumano K, Ban N, Minamitani Y, Kurokawa M, and Chiba S.
  • 雑誌名: Bone Marrow Transplantation 42 ページ: 697-699
  • 査読あり
• [雑誌論文] Simultaneous appearance of central nervous system relapse and subarachnoid hemorrhage during or after targeted therapies for acute promyelocytic leukemia (2008)
  • 著者名/発表者名: Nagai S, Asai T, Watanabe T, Oshima K, Hangaishi A, Kanda Y, Motokura T, Chiba S, Aoki S, Ohtomo K, and Kurokawa M.
  • 雑誌名: Annals of Hematology 87 ページ: 593-595
  • 査読あり
• [雑誌論文] Hemorrhagic cystitis in a patient receiving gemtuzumab ozogamicin for relapsed acute promvelocytic leukemia after cord blood transplantation. (2008)
  • 著者名/発表者名: Yoshimi A, Asai T, Hangaishi A, Takahashi T, Chiba S, and Kurokawa M.
  • 雑誌名: Annals of Hematology 87 ページ: 851-852
  • 査読あり
• [雑誌論文] Long-term ultra-low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation. (2008)
  • 著者名/発表者名: Asano-Mori Y, Kanda Y, OshimaK, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, IzutsuK, Asai T, Hangaishi A, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: American Journal of Hematology 83 ページ: 472-476
  • 査読あり
• [雑誌論文] Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome poor prognosis associated with positive FDG-PET scan before transplantation. (2008)
  • 著者名/発表者名: Yoshimi A, Izutsu K, Takahashi M, Oshima K, Kako S, Kanda Y, Motokura T, Chiba S, Momose T, Ohtomo K, and Kurokawa M.
  • 雑誌名: American Journal of Hematology 83 ページ: 477-481
  • 査読あり
• [雑誌論文] A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: reduced cyclophosphamide combined with etoposide and total body irradiation. (2008)
  • 著者名/発表者名: Yoshimi A, Nannya Y, Sakata-Yanagimoto M, Oshima K, Takahashi T, Kanda Y, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: American Journal of Hematology 83 ページ: 635-639
  • 査読あり
• [雑誌論文] Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: Does body weight matter? (2008)
  • 著者名/発表者名: Kanda Y, Okamoto S, Tauchi T, Kisaki M, Inokuchi K, Yabe M, Yokoyama K, Ito Y, Kimura Y, Higasbibara M, Bessho M, Ando K, Chiba S, Kurokawa M, Oshimi K, Dan K, Ohyashiki K, and Ikeda Y.
  • 雑誌名: American Journal of Hematology 83 ページ: 835-839
  • 査読あり
• [雑誌論文] A case of adult Langerhans cell histiocytosis showing successfully regenerated osseous tissue of the skull after chemotherapy. (2008)
  • 著者名/発表者名: Suzuki T, Izutsu K, Kako S, Ohta S, Hangaishi A, Kanda Y, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: Internatinal Journal of Hematology 87 ページ: 284-288
  • NAID: 10021256068
  • 査読あり
• [雑誌論文] Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. (2008)
  • 著者名/発表者名: Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 87 ページ: 310-318
  • NAID: 10021256200
  • 査読あり
• [雑誌論文] Elevated serum levels in interleukin-2 receptor in chronic eosinophilic leukemia / hypereosinophilic syndrome with FIP1L1-PDGFRα fusion gene. (2008)
  • 著者名/発表者名: Kataoka K, Izutsu K, Nagai S, Hangaishi A, Motokura T, Takahashi T, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 87 ページ: 440-441
  • 査読あり
• [雑誌論文] ESHAP therapy was very effective for a patient with Langerhans cell sarcoma. (2008)
  • 著者名/発表者名: Yoshimi A, Kumano K, Motokura T, Takazawa Y, Oota S, Chiba S, Takahashi T, Fukayama M, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 87 ページ: 532-537
  • 査読あり
• [雑誌論文] Herpes simplex encephalitis and subsequent cytomegalovirus encephalitis after chemoradiotherapy for central nervous system relapse of diffuse large B-cell lymphoma: a case report and literature review. (2008)
  • 著者名/発表者名: Suzuki H, Hangaishi A, Hosoya N, Watanabe T, Kanda Y, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 87 ページ: 538-541
  • 査読あり
• [雑誌論文] Late onset pneumatosis cystoides intestinalis associated with non-infectious pulmonary complinations after allogeneic hematopoietic stem cell transplantation. (2008)
  • 著者名/発表者名: Suzuki H, Izutsu K, Nagai S, Watanabe T, Oshima K, Kanda Y, Motokura T, Chiba S, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 88 ページ: 116-118
  • 査読あり
• [雑誌論文] Molecular and cytogenetic response of chronic myelogenous leukemia treated with imatinib mesvlate: one institutional experience in Japan. (2008)
  • 著者名/発表者名: Nannya Y, Yokota H, Sato Y, Yamamoto G, Asai T, Ichikawa M, Watanabe T, Kumano K, Hangaishi A, Takahashi T, Chiba S, and Kurokawa M.
  • 雑誌名: International Journal of Hematology 88 ページ: 159-164
  • 査読あり
• [雑誌論文] Expression and tyrosine phosphorylation of Crk associated substrate lymphocyte type (Cas-L) protein in human neutrophils. (2008)
  • 著者名/発表者名: Nakamoto T, Seo S, Sakai R, Kato T, Kutsuna H, Kurokawa M, Nods M, Miyasaka N, and Kitagawa S.
  • 雑誌名: Journal of Cellular Biochemistry 105 ページ: 121-128
  • 査読あり
• [雑誌論文] Case Report: Persistent cytomegalovirus (CMV) infection after haploidentical hematopoietic stem cell transplantation using in vivo alemtuzumab: emergence of resistant CMV due to mutations in the UL97 and UL54 genes. (2008)
  • 著者名/発表者名: Oshima K, Kanda Y, Kako S, Asano-Mori Y, Watanabe T, Motokura T, Chiba S, Shiraki K, and Kurokawa M.
  • 雑誌名: Journal of Medical Virology 80 ページ: 1769-1775
  • 査読あり
• [雑誌論文] AML1/Runx1 negatively regulates quiescent hematopoieticstem cells in adulthematopoiesis (2008)
  • 著者名/発表者名: Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M.
  • 雑誌名: The Journal of Immunology 180 ページ: 4402-4408
  • 査読あり
• [雑誌論文] AML1-Evi-1 specifically transforms hematopoietic stem cells throughfusion of the entire Evi-1 sequence to AML1 (2008)
  • 著者名/発表者名: Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.
  • 雑誌名: Leukemia 22 ページ: 1241-1249
  • 査読あり
• [雑誌論文] Drug-induced hypersensltivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia (2008)
  • 著者名/発表者名: Suzuki H, Asai T, Tamaki Z, Yoshimi A, Hangaishi A, Kanda Y, Motokura T, Chiba S, Kurokawa M.
  • 雑誌名: Haematologica 93 ページ: 469-470
  • 査読あり
• [雑誌論文] Evi-1promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-βsignaling (2008)
  • 著者名/発表者名: Sato T, Goyama S, Nitta E, Takeshita M, Yoshimi M, Nakagawa M, Nakagwa M, Kawazu M, Ichikawa M, Kurokawa M.
  • 雑誌名: Cancer Science 99 ページ: 1407-1413
  • NAID: 10024008671
  • 査読あり
• [雑誌論文] Disseminated adenovirus disease by multiple adenovirus serotypes following alloogeneic hematopoietic stem cell transplantation (2008)
  • 著者名/発表者名: Suzuki HI, Asai T, Okada K, Kazuyama Y, Takahashi T, Kanda Y, Chiba S, Kurokawa M.
  • 雑誌名: Biology of Blood & Marrow Transplantation 14 ページ: 353-355
  • 査読あり
• [雑誌論文] The origin of neoplastic mast cells in systematic mastocytosis with AML1/ETO-positiveacute myeloid leukemia (2008)
  • 著者名/発表者名: Nagai S, Ichikawa M, Takahashi T, Sato H, Yokota H, Oshima K, Izutsu K, Hangaishi A, Kanda Y, Motokura T, Chiba S, Yatomi Y, Kurokawa M.
  • 雑誌名: Experimental Hematology 35 ページ: 1747-1752
  • 査読あり
• [雑誌論文] Decreased incidence of acute graft-versus-host disease by continuous infusion of cyclosporine with a higher target blood level (2008)
  • 著者名/発表者名: Oshima K, Kanda Y, Nakasone H, Arai S, Nishimoto N, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M.
  • 雑誌名: American Journal of Hematology 83 ページ: 226-232
  • 査読あり
• [雑誌論文] Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab (2008)
  • 著者名/発表者名: Kako S, Kanda Y, Oshlma K, Nlshimoto N, Sato H, Watanabe T, Hosoya N, Motokura T, Miyakoshi S, Taniguchi S, Kamijo A, Takahashi K, Chiba S, Kurokawa M.
  • 雑誌名: American Journal of Hematology 83 ページ: 247-249
  • 査読あり
• [雑誌論文] False-positive Aspergillus galactomannan antigenaemia after haematopoietic stem cell transplantation (2008)
  • 著者名/発表者名: Asano-Mori Y, Kanda Y, Oshima K, kako S, Shinohara A, Nakasone H, Kaneko M, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, motokura T, Chiba S, Kurokawa M.
  • 雑誌名: The Journal of Antimicrobial Chemotherapy 61 ページ: 411-416
  • 査読あり
• [雑誌論文] Both Notchl and Notch2 contribute to the regulation of melanocyte stem cells (2008)
  • 著者名/発表者名: Kumano K, Masuda S, Sata M, Saito T, Lee SY, Yanagimoto-Sakata M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S.
  • 雑誌名: Pigment Cell Melanoma Research 21 ページ: 70-78
  • 査読あり
• [雑誌論文] The origin of neoplastic mast cells in systemic mastocytosis with AML1/ETO positive acute myeloid leukemia (2007)
  • 著者名/発表者名: 黒川峰夫, 他
  • 雑誌名: Experimental Hematology 巻: 35 号: 11 ページ: 1747-1752
  • DOI: 10.1016/j.exphem.2007.08.016
  • 査読あり
• [雑誌論文] Expression profiling of immature thymocytes revealed a novel homebox gene that regulates double-negative thymocyte development (2007)
  • 著者名/発表者名: Kawazu M, Yamamoto G, Yoshimi M, Yamamoto K, Asai T, Ichikawa M, Seo S, Nakagawa M, Chiba S, Kurokawa M, Ogawa S.
  • 雑誌名: The Journal of Immunology 179 ページ: 5445-5345
  • 査読あり
• [雑誌論文] Unbalanced translocation der(1;7)(q10;p10)deflnes a unique clinicopathological subgroup of myeloid neoplasms (2007)
  • 著者名/発表者名: Sanada M, Uike N, Ohyashiki K, Ozawa K, Lili W, Hangaishi A, Kanda Y, Chiba S, Kurokawa M, Omine M, Mitani K, Ogawa S.
  • 雑誌名: Leukemia 21 ページ: 992-997
  • 査読あり
• [雑誌論文] FDG-PET in T-cell and NK-cell neoplasms (2007)
  • 著者名/発表者名: Kako S, Izutsu K, Ota Y, Minatani Y, Sugaya M, Momose T, Ohtomo K, Kanda Y, Chiba S, Motokura T, Kurokawa M.
  • 雑誌名: Annals of Oncology 18 ページ: 1685-1690
  • 査読あり
• [雑誌論文] Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation (2007)
  • 著者名/発表者名: Kako S, Kanda Y, Sato T, Goyama S, Noda N, Shoda E, Osgima K, Inoue M, Izutsu K, Watanabe T, Motokura T, Chiba S, fukuyama M, Kurokawa M.
  • 雑誌名: American Jounal of Hematology 82 ページ: 386-390
  • 査読あり
• [雑誌論文] Regression of the tumor after withdrawal of cyclospoorine in relapsed extranodal natural killer/T cell lymphoma following alloogeneic hematopoietic stem cell transplantation (2007)
  • 著者名/発表者名: Kako S, Izutsu K, Oshima K, Sato H, Kanda Y, Motokura T, Chiba S, Kurokawa M.
  • 雑誌名: American Journal of Hematology 82 ページ: 937-939
  • 査読あり
• [雑誌論文] A prospective study of cyclosporine A treatment of patients with low-risk myelodysplastic syndrome: presence of CD55(-)CD59(-)blood cells predicts platelet response (2007)
  • 著者名/発表者名: Ishikawa T. Tohyama K, Nakao S, Yoshida Y, Teramura M, Motoji T, Takatoku M, Kurokawa M, Mitani K, Uchiyama T, Omine M.
  • 雑誌名: International Journal of Hematology 86 ページ: 150-157
  • NAID: 10019733994
  • 査読あり
• [雑誌論文] Splenic peliosis in a patient with aplastic anemia during danazol therapy (2007)
  • 著者名/発表者名: Arai S, Asai T, Uozaki H, Hangaishi A, Kanda Y, Motokura T, Chiba S, Kurokawa M.
  • 雑誌名: International Journal of Hematology 86 ページ: 329-332
  • NAID: 10019990152
  • 査読あり
• [雑誌論文] Presumptive treatment strategy for aspergillosis in allogeneic haematopoietic stem cell transplant recipients (2007)
  • 著者名/発表者名: Oshima K, Kanda Y, Asano-Mori Y, Nishimoto N, Arai S, Nagai S, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M.
  • 雑誌名: The Journal of Antimicrobial Chemotherapy 60 ページ: 350-355
  • 査読あり
• [雑誌論文] Long-term sustained mixed chimerism after allogeneic stem cell transplantation in a patient with severe aplastic anemia (2007)
  • 著者名/発表者名: Saito AM, Chiba S, Ogawa S, Kanda Y, Hirai H, Kurokawa M.
  • 雑誌名: Internal Medicine 46 ページ: 1923-1926
  • NAID: 130000078607
  • 査読あり
• [雑誌論文] Highly sensitive method for genome-wide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polyraorphism genotyping microarrays (2007)
  • 著者名/発表者名: Yamamoto G, Nannya Y, Kato M, Sanada M, Levine RL, Kawamata N, Hangaishi A, Kurokawa M, Chiba S, Gilliland DG, Koeffler HP, Ogawa S.
  • 雑誌名: American Journal of Human Genetics 81 ページ: 114-126
  • 査読あり
• [雑誌論文] Evaluation of genome-wide power of genetic association studies based on empirical data from the hapmap project (2007)
  • 著者名/発表者名: Nannya Y, Taura K, Kurokawa M, Chiba S, Ogawa S.
  • 雑誌名: Human Molecular Genetics 16 ページ: 2494-2505
  • 査読あり
• [雑誌論文] Immunotherapy against metastatic renal cell carcinoma with mature dendritic cells (2007)
  • 著者名/発表者名: Matsumoto A, Haraguchi K, Takahashi T, Azuma T, Kanda Y, Tomita K, Kurokawa M, Ogawa S, Takahashi K, Chiba S, Kitamura T.
  • 雑誌名: International Journal of Urology 14 ページ: 277-283
  • NAID: 10020163110
  • 査読あり
• [学会発表] Molecular pathogenesis and therapeutic targets of hematological malignancies (2011)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第70回日本癌学会学術総会
  • 発表場所: 名古屋
  • 年月日: 2011-10-05
• [学会発表] Molecular pathogenesis and therapeutic targets of hematological malignancies (2011)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第70回日本癌学会学術総会
  • 発表場所: 名古屋国際会議場(愛知)(招待講演)
  • 年月日: 2011-10-05
• [学会発表] Regulation of normal and malignant hematopoiesis by Evil (2011)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: USA-Japan Cooperative Cancer Research Workshop
  • 発表場所: 葉山(神奈川)
  • 年月日: 2011-02-25
• [学会発表] Regulation of normal and malignant hematopoiesis by Evil. (2011)
  • 著者名/発表者名: Kurokawa M.
  • 学会等名: USA-Japan Cooperative Cancer Research Workshop
  • 発表場所: 湘南ヴィレッジセンター(神奈川)
  • 年月日: 2011-02-25
• [学会発表] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells (2010)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 39th ISEH Annual Scientific Meeting
  • 発表場所: オーストラリア
  • 年月日: 2010-09-16
• [学会発表] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. (2010)
  • 著者名/発表者名: Kurokawa M.
  • 学会等名: ISEH 2010 39^<th> Annual Scientific Meeting
  • 発表場所: メルボルン(オーストラリア)
  • 年月日: 2010-09-16
• [学会発表] The pathogenesis and novel therapeutics of myelodysplastic syndrome (2009)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第68回日本癌学会学術総会
  • 発表場所: 横浜
  • 年月日: 2009-10-03
• [学会発表] The pathogenesis and novel therapeutics of myelodysplastic syndrome. (2009)
  • 著者名/発表者名: Kurokawa M.
  • 学会等名: The 68^<th> Annual Meeting of the Japanese Cancer Association
  • 発表場所: 横浜
  • 年月日: 2009-10-03
• [学会発表] Deregulated transcription factors in leukemia and MDS (2009)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: The Korean AML/MDS Working Party Symposium
  • 発表場所: 韓国
  • 年月日: 2009-05-30
• [学会発表] 造血系転写因子と白血病 (2008)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第70回日本血液学会総会
  • 発表場所: 京都
  • 年月日: 2008-10-10
• [学会発表] 造血系転写因子と白血病 (2008)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第70回日本血液学会総会
  • 発表場所: 京都市
  • 年月日: 2008-10-10
• [学会発表] The pathogenetic significance of deregulated transcription factors in hematological malignancies (2008)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 上原記念財団シンポジウム
  • 発表場所: 東京
  • 年月日: 2008-07-01
• [学会発表] The pathogenetic significance of deregulated transcription factors in hematological malignancies (2008)
  • 著者名/発表者名: Kurokawa, M.
  • 学会等名: The Uehara Memorial Foundation Symposium
  • 発表場所: 東京都
  • 年月日: 2008-07-01
• [学会発表] 造血系転写因子と白血病(教育講演) (2007)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第69回日本血液学会・第49回日本臨床血液学会
  • 発表場所: 横浜市
  • 年月日: 2007-10-13
• [学会発表] 転写因子による造血制御と白血病発症機構 (2007)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第66回日本癌学会学術総会
  • 発表場所: 横浜
  • 年月日: 2007-10-04
• [学会発表] 転写因子による造血制御と白血病発症機構(シンポジウム) (2007)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: 第66回日本癌学会学術総会
  • 発表場所: 横浜市
  • 年月日: 2007-10-04
• [学会発表] Transcription factors in hematopoiesis and leukemogenesis (2007)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: The 4th AML/MDS Working Party Symposium Korea-Japan Joint Symposium
  • 発表場所: 韓国
  • 年月日: 2007-09-07
• [学会発表] Transcription factors in hematopolesis and leukemogenesis (2007)
  • 著者名/発表者名: 黒川峰夫
  • 学会等名: The 4th AML/MDS Working Party Symposium Korea-Japan Joint Symposium
  • 発表場所: 韓国・釜山市
  • 年月日: 2007-09-07
• [備考]
  • URL: http://www.u-tokyo-hemat.com/