| 研究課題/領域番号 |
19F19329
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 補助金 |
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| 応募区分 | 外国 |
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| 審査区分 |
小区分13040:生物物理、化学物理およびソフトマターの物理関連
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| 研究機関 | 京都大学 |
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研究代表者 |
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| 研究分担者 |
GIBBONS ANDREW 京都大学, 高等研究院, 外国人特別研究員
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| 研究期間 (年度) |
2019-10-11 – 2022-03-31
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| 研究課題ステータス |
完了 (2021年度)
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| 配分額 *注記 |
2,200千円 (直接経費: 2,200千円)
2021年度: 700千円 (直接経費: 700千円)
2020年度: 800千円 (直接経費: 800千円)
2019年度: 700千円 (直接経費: 700千円)
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| キーワード | Paper submitted / Water flow in OM film / Electrophoresis / OM films on aluminium / Large image on OM film / Maskless printing of OM / Expanded film size of OM / Microfluidic flow in OM / Improved OM on plastic / Shared OM with community |
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| 研究開始時の研究の概要 |
A method for controlling microstructure in polymers was recently discovered, known as the Organized Microfibrillation (OM). This process uses light to precisely create holes within a polymer film which results in colour. With the OM process designs can be made in different polymers.
The formation of holes due to the OM process allows liquids to flow within a polymer film, however the nature of the flow is not yet understood. The goal of this project is to study the liquid flow within OM designed films so that the process can be used for microfluidic applications in the future.
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| 研究実績の概要 |
In the final stages of the project, ending 2021, I began a collaboration with a Genetics research group to help develop the Organized Microfibrillation process for microfluidics. Up until this point I had difficulty getting water based solutions into the porous OM polymer films. Minor success was achieved with common additives and surfactants. With this new collaboration we were successfully able to identify some chemicals that enabled the flow of water based solutions in my OM channels. With this breakthrough, we were able to achieve other milestones with the OM films. Relevant biological materials, such as proteins and saccharides could enter the channels and could be tracked by fluorescent microscope. Finally we were able to achieve separation of biological materials with differing molecular weights, including separation of proteins and saccharaides, and separation of insulin and inert SARS-COV2 capsid. Separation was achieved by making OM channels with differing porosity such that larger molecules were blocked by the pores. These achievements have been included in a paper that was submitted to Nature Communications.
With the same collaborators I also worked on how to move liquids through OM films without capillary action. A weakness of OM for microfluidics is the lack of pumping capability. During this time I tried applying electrophoresis to my OM films. I and my collaborators explored different experimental setups and conditions and were able to achieve electrophoretic flow preliminary experiments.
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| 現在までの達成度 (段落) |
令和3年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和3年度が最終年度であるため、記入しない。
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