| 研究課題/領域番号 |
19F19408
|
|---|
| 研究種目 |
特別研究員奨励費
|
| 配分区分 | 補助金 |
|---|
| 応募区分 | 外国 |
|---|
| 審査区分 |
小区分59040:栄養学および健康科学関連
|
|---|
| 研究機関 | 早稲田大学 |
|---|
研究代表者 |
秋本 崇之 早稲田大学, スポーツ科学学術院, 教授 (00323460)
|
|---|
| 研究分担者 |
LEE MINJUNG 早稲田大学, スポーツ科学学術院, 外国人特別研究員
|
|---|
| 研究期間 (年度) |
2019-11-08 – 2022-03-31
|
| 研究課題ステータス |
完了 (2020年度)
|
| 配分額 *注記 |
2,300千円 (直接経費: 2,300千円)
2020年度: 1,000千円 (直接経費: 1,000千円)
2019年度: 1,000千円 (直接経費: 1,000千円)
|
|---|
| キーワード | progeria / non-cording RNAs / activity / development / exercise |
|---|
| 研究開始時の研究の概要 |
Our group has focused on microRNAs (miRNAs) to investigate their roles in skeletal muscle biology. We found a mouse lacking specific miRNAs (KO mice) showed accelerated aging phenotype. The KO mice showed low physical activity, growth retardation, hair loss, hair graying and kyphosis earlier than WT mice. The aging phenotypes are progressive and result in short lifespan in the KO mice.
In the present study, we define the function of the miRNAs on aging.
|
| 研究実績の概要 |
MicroRNA (miRNA) is a small non-coding RNA which represses its target genes at post-transcriptional level. In previous studies, the host researcher established genetically modified mice of several miRNAs which are involved in exercise-induced skeletal muscle adaptation. Coincidentally, we found that certain modification of miRNAs caused accelerated aging. To clarify the aging factor(s), first we determined the aging phenotypes of the GM mice during the fellowship tenure.
The average lifespan of GM mice were significantly shorter than those for males and females for WT. The median survival time was also significantly shorter in GM mice than in WT mice. Frailty index of the GM mice was significantly higher than that of WT mice. Collectively, these results suggested that the aging process is accelerated in the GM mice and it eventually shortened the lifespan of the mice.
|
| 現在までの達成度 (段落) |
翌年度、交付申請を辞退するため、記入しない。
|
| 今後の研究の推進方策 |
翌年度、交付申請を辞退するため、記入しない。
|
