| 研究課題/領域番号 |
19H05646
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| 研究種目 |
基盤研究(S)
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| 配分区分 | 補助金 |
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| 審査区分 |
大区分G
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| 研究期間 (年度) |
2019-06-26 – 2024-03-31
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| 研究課題ステータス |
採択後辞退 (2023年度)
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| 配分額 *注記 |
166,270千円 (直接経費: 127,900千円、間接経費: 38,370千円)
2023年度: 33,020千円 (直接経費: 25,400千円、間接経費: 7,620千円)
2022年度: 32,630千円 (直接経費: 25,100千円、間接経費: 7,530千円)
2021年度: 32,110千円 (直接経費: 24,700千円、間接経費: 7,410千円)
2020年度: 31,720千円 (直接経費: 24,400千円、間接経費: 7,320千円)
2019年度: 36,790千円 (直接経費: 28,300千円、間接経費: 8,490千円)
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| キーワード | hippocampus / cortex / oscillations / memory / engram / phyiology / consolidation / Memory / Hippocampus / Oscillations / Physiology |
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| 研究開始時の研究の概要 |
The overall goal of this project is to better understand memory. To achieve this we will combine techniques to label and monitor groups of neurons encoding a specific event in an animal’s life. This approach allows us to focus on how groups of neurons organize their activity during learning and recall of information. Our experiments will clarify how their connections and dynamic interaction underlie memory in healthy brain and uncover new interventions to treat memory loss that accompanies aging and disease.
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| 研究実績の概要 |
During the previous fiscal year we have continued to conducted experiments investigating how oscillations and spiking organize the precise activity of subsets of neurons related to memory and experience. We published a manuscript detailing a state-dependent impact of transient silencing of the CA2 subfield of the hippocampus on the dynamics of network activity in the structure, featuring our newly developed machine learning based algorithm for the decoding of position based on the spikes recorded on a single tetrode. This allowed us, for the first time, to look at positional decoding in a subfield and state dependent manner. We have also published a review paper on our previous work on the differential contributions of the CA2 and CA3 subfields to sharp-wave ripples and replay. We have collected data using closed-loop optogenetics and using high-density neuropixels recording that will be analyzed in the coming fiscal year.
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| 現在までの達成度 (段落) |
翌年度、交付申請を辞退するため、記入しない。
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| 今後の研究の推進方策 |
翌年度、交付申請を辞退するため、記入しない。
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| 評価記号 |
中間評価所見 (区分)
A: 研究領域の設定目的に照らして、期待どおりの進展が認められる
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