| 研究課題/領域番号 |
19J11009
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 補助金 |
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| 応募区分 | 国内 |
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| 審査区分 |
小区分19010:流体工学関連
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
Sathish Shivani 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC2)
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| 研究期間 (年度) |
2019-04-25 – 2021-03-31
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| 研究課題ステータス |
完了 (2020年度)
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| 配分額 *注記 |
2,100千円 (直接経費: 2,100千円)
2020年度: 1,000千円 (直接経費: 1,000千円)
2019年度: 1,100千円 (直接経費: 1,100千円)
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| キーワード | microfluidic / biomarker detection / kinetic enhancements / protein immobilization / PMMA microfluidics / Point of care testing / Fluid handling |
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| 研究開始時の研究の概要 |
A large population around the world suffer from several treatable disorders if diagnosed early. However, the varied costs and accessibility to healthcare systems hinders patients from getting regular health screens. This can be addressed by providing the population with economical devices for efficient diagnosis to ensure early treatment. To address this demand, my aim is to develop miniaturized and rapid disease diagnostic tools by exploiting the benefits of microfluidics, to enable faster and more sensitive disease detection.
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| 研究実績の概要 |
When a person is afflicted with a disease, quantities of biomarkers are elevated. This research is focused on developing sensitive and rapid microfluidic systems to detect a wide range of biomarkers. Here, kinetic enhancements in microfluidic bioassay systems were investigated using novel 3D glass devices. Real-time binding events between fluorescently-labelled receptor and ligand antibodies were analyzed. Combining experimental measurements with scaling analysis, two key control dimensionless parameters were proposed to achieve “rapid” and “sensitive” ligand detection: a local Peclet number and a kinetic Damkohler number. Finally, we summarized our observations by providing design rules to support the development of fast and sensitive microfluidic bioassay systems.
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| 現在までの達成度 (段落) |
令和2年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和2年度が最終年度であるため、記入しない。
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